ADRB1

Summary

Gene Symbol: ADRB1
Description: adrenoceptor beta 1
Alias: ADRB1R, B1AR, BETA1AR, RHR, beta-1 adrenergic receptor, adrenergic, beta-1-, receptor, beta-1 adrenoceptor, beta-1 adrenoreceptor
Species: human

Top Publications

  1. pmc Beta-1-adrenoceptor genetic variants and ethnicity independently affect response to beta-blockade
    Daniel Kurnik
    Department of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    Pharmacogenet Genomics 18:895-902. 2008
  2. ncbi A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated so
    Arne Heydorn
    Laboratory for Molecular Pharmacology, Department of Pharmacology, Panum Institute, University of Copenhagen, DK 2200 Copenhagen, Denmark
    J Biol Chem 279:54291-303. 2004
  3. ncbi beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95
    J Xu
    Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 276:41310-7. 2001
  4. pmc GRK5 Gln41Leu polymorphism is not associated with sensitivity to beta(1)-adrenergic blockade in humans
    Daniel Kurnik
    Vanderbilt University, Nashville, TN, USA
    Pharmacogenomics 10:1581-7. 2009
  5. pmc Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer
    Mehrdad Faizi
    Stanford Behavioral and Functional Neuroscience Laboratory, Stanford Institute for Neuro Innovation and Translational Neurosciences, Stanford University School of Medicine, USA
    Neurobiol Dis 43:397-413. 2011
  6. ncbi beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors
    L A Hu
    Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 275:38659-66. 2000
  7. ncbi G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95
    Liaoyuan A Hu
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:1607-13. 2002
  8. pmc Association of 14-3-3 proteins to beta1-adrenergic receptors modulates Kv11.1 K+ channel activity in recombinant systems
    Antonio S Tutor
    Departamento de Biologia Molecular and Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Mol Biol Cell 17:4666-74. 2006
  9. ncbi Beta 1/beta 2-adrenergic receptor heterodimerization regulates beta 2-adrenergic receptor internalization and ERK signaling efficacy
    Catherine Lavoie
    Centre de Recherche, Institut de Cardiologie de Montreal, Montreal, Quebec, H1T 1C8, Canada
    J Biol Chem 277:35402-10. 2002
  10. pmc Association of the beta-1 adrenergic receptor carboxyl terminal variants with left ventricular hypertrophy among diabetic and non-diabetic survivors of acute myocardial infarction
    Anna E Hakalahti
    Institute of Biomedicine, Department of Anatomy and Cell Biology, University of Oulu, PO Box 5000, FI 90014 Oulu, Finland
    Cardiovasc Diabetol 9:42. 2010

Research Grants

  1. PKA targeting: A novel mechanism for GPCR resensitization
    SULEIMAN WAKIM BAHOUTH; Fiscal Year: 2012
  2. Atrial Fibrillation in Hyperthyroidism: Active Antibodies to Autonomic Receptors
    DAVID KEM; Fiscal Year: 2013
  3. Virtual screening studies of the Beta-2 Adrenergic Receptor
    Dahlia R Weiss; Fiscal Year: 2012
  4. Howard A Rockman; Fiscal Year: 2016
  5. Beta-Adrenergic Receptor Modulation of Insulin Signaling
    Robert Walker; Fiscal Year: 2012
  6. Endothelial BK Channel Regulation by Caveolae Targeting
    Hon Chi Lee; Fiscal Year: 2010
  7. DOUGLAS TILLEY; Fiscal Year: 2016
  8. Targeting and Function of Golgi Membrane Proteins
    Carolyn E Machamer; Fiscal Year: 2011
  9. bZIP Repression of Adrenergic Receptor RNA in Neurons
    CURTIS MACHIDA; Fiscal Year: 2006
  10. Transcription & Function of Adipocyte Beta3AR in Obesity
    Sheila Collins; Fiscal Year: 2006

Detail Information

Publications194 found, 100 shown here

  1. pmc Beta-1-adrenoceptor genetic variants and ethnicity independently affect response to beta-blockade
    Daniel Kurnik
    Department of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    Pharmacogenet Genomics 18:895-902. 2008
    ..The purpose of this study was to determine whether ethnic differences in response to beta-blockade can be explained by differing distributions of functional genetic variants in the beta1-AR...
  2. ncbi A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated so
    Arne Heydorn
    Laboratory for Molecular Pharmacology, Department of Pharmacology, Panum Institute, University of Copenhagen, DK 2200 Copenhagen, Denmark
    J Biol Chem 279:54291-303. 2004
    ..It is concluded that the tail library provides useful information on the general importance of certain adaptor proteins, for example, in this case, ruling out EBP50 as being a broad spectrum-recycling adaptor...
  3. ncbi beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95
    J Xu
    Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 276:41310-7. 2001
    The beta1-adrenergic receptor (beta1AR) is known to be localized to synapses and to modulate synaptic plasticity in many brain regions, but the molecular mechanisms determining beta1AR subcellular localization are not fully understood...
  4. pmc GRK5 Gln41Leu polymorphism is not associated with sensitivity to beta(1)-adrenergic blockade in humans
    Daniel Kurnik
    Vanderbilt University, Nashville, TN, USA
    Pharmacogenomics 10:1581-7. 2009
    ..We hypothesized that the GRK5 Gln41Leu variant contributes to interindividual variability in response to beta-blockade and to the ethnic difference in sensitivity between black and Caucasian individuals...
  5. pmc Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer
    Mehrdad Faizi
    Stanford Behavioral and Functional Neuroscience Laboratory, Stanford Institute for Neuro Innovation and Translational Neurosciences, Stanford University School of Medicine, USA
    Neurobiol Dis 43:397-413. 2011
    ..Furthermore, due to the significant involvement of noradrenergic system in the cardiovascular function further safety and translational studies will be needed to ensure the safety and efficacy of this approach...
  6. ncbi beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors
    L A Hu
    Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 275:38659-66. 2000
    ....
  7. ncbi G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95
    Liaoyuan A Hu
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:1607-13. 2002
    ..Regulation of protein association through receptor phosphorylation may be a general mechanism used by G protein-coupled receptors that associate via PDZ domain-mediated protein/protein interactions...
  8. pmc Association of 14-3-3 proteins to beta1-adrenergic receptors modulates Kv11.1 K+ channel activity in recombinant systems
    Antonio S Tutor
    Departamento de Biologia Molecular and Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Mol Biol Cell 17:4666-74. 2006
    ..Our results suggest that the dynamic association of 14-3-3 proteins to both beta(1)AR and Kv11.1 channels is involved in the adrenergic modulation of this critical regulator of cardiac repolarization and refractoriness...
  9. ncbi Beta 1/beta 2-adrenergic receptor heterodimerization regulates beta 2-adrenergic receptor internalization and ERK signaling efficacy
    Catherine Lavoie
    Centre de Recherche, Institut de Cardiologie de Montreal, Montreal, Quebec, H1T 1C8, Canada
    J Biol Chem 277:35402-10. 2002
    ..Taken together, our data suggest that heterodimerization between beta(1)AR and beta(2)AR inhibits the agonist-promoted internalization of the beta(2)AR and its ability to activate the ERK1/2 MAPK signaling pathway...
  10. pmc Association of the beta-1 adrenergic receptor carboxyl terminal variants with left ventricular hypertrophy among diabetic and non-diabetic survivors of acute myocardial infarction
    Anna E Hakalahti
    Institute of Biomedicine, Department of Anatomy and Cell Biology, University of Oulu, PO Box 5000, FI 90014 Oulu, Finland
    Cardiovasc Diabetol 9:42. 2010
    The beta-1 adrenergic receptor (beta1AR) plays a fundamental role in the regulation of cardiovascular functions...
  11. ncbi Glycosylation of beta(1)-adrenergic receptors regulates receptor surface expression and dimerization
    Junqi He
    Department of Pharmacology, 5113 Rollins Research Center, Emory University School of Medicine, 1510 Clifton Rd, Atlanta, GA 30322, USA
    Biochem Biophys Res Commun 297:565-72. 2002
    ..These data reveal that the beta(1)AR is glycosylated on Asn15 and that this glycosylation plays a role in regulating beta(1)AR surface expression and dimerization...
  12. doi β1, β2, and β3 adrenoceptors and Na+/H+ exchanger regulatory factor 1 expression in human bronchi and their modifications in cystic fibrosis
    Florian Bossard
    INSERM, UMR 915, l institut du thorax, IRT UN, 8 quai Moncousu, Nantes, France
    Am J Respir Cell Mol Biol 44:91-8. 2011
    ..Furthermore, NHERF1 may be a new therapeutic target in patients with CF, to facilitate the trafficking of mutated CFTR to plasma membrane...
  13. ncbi Heterodimerization of alpha 2A- and beta 1-adrenergic receptors
    Jianguo Xu
    Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 278:10770-7. 2003
    ..These data reveal an interaction between beta(1)AR and alpha(2A)AR that is regulated by glycosylation and that may play a key role in cross-talk and mutual regulation between these receptors...
  14. pmc CRM 1-mediated degradation and agonist-induced down-regulation of beta-adrenergic receptor mRNAs
    Ying Bai
    Department of Integrative Biosciences, School of Dentistry, Oregon Health and Science University, Portland, OR 97239, USA
    Biochim Biophys Acta 1763:1076-89. 2006
    ..Our results suggest that CRM 1-dependent NES-mediated mechanisms influence the degradation and agonist-mediated down-regulation of the beta1-AR mRNAs...
  15. ncbi Arg389Gly beta 1-adrenoceptor polymorphism varies in frequency among different ethnic groups but does not alter response in vivo
    H G Xie
    Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Pharmacogenetics 11:191-7. 2001
    ....
  16. ncbi Beta1-adrenergic receptor polymorphisms, QTc interval and occurrence of symptoms in type 1 of long QT syndrome
    Kristian J Paavonen
    Department of Medicine, University of Helsinki, 00290 Helsinki, Finland
    Int J Cardiol 118:197-202. 2007
    ....
  17. pmc beta(1)- and beta(2)-adrenoceptor responses in cardiomyocytes derived from human embryonic stem cells: comparison with failing and non-failing adult human heart
    M Brito-Martins
    National Heart and Lung Institute, Imperial College, London, UK
    Br J Pharmacol 153:751-9. 2008
    ..We have therefore performed detailed pharmacological analysis of the beta-adrenoceptor responses in developing hESC-CM...
  18. doi Beta-adrenergic receptor gene polymorphisms and hemodynamic response to dobutamine during dobutamine stress echocardiography
    C L Aquilante
    Department of Pharmacy Practice, University of Florida College of Pharmacy, Gainesville, FL 32610, USA
    Pharmacogenomics J 8:408-15. 2008
    ..These data suggest that the four selected beta(1)- and beta(2)-AR polymorphisms do not substantially influence the magnitude of hemodynamic response to dobutamine during DSE...
  19. doi Variation in the genes encoding vesicular monoamine transporter 2 and beta-1 adrenergic receptor and antidepressant treatment outcome
    James J Crowley
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Psychiatr Genet 18:248-51. 2008
    ..k.a. VMAT2) and ADRB1 (encoding beta-1 adrenergic receptor) as candidate genes for a human pharmacogenetic study...
  20. doi Receptor specific crosstalk and modulation of signaling upon heterodimerization between β1-adrenergic receptor and somatostatin receptor-5
    Rishi K Somvanshi
    Faculty of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, The University of British Columbia, Vancouver, BC, Canada
    Cell Signal 23:794-811. 2011
    ..Taken together, the functional consequences of results described here might have relevance in the cardiovascular system where SSTR and AR subtypes play important roles...
  21. ncbi Quantitative assessment of beta 1- and beta 2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer
    Jean Francois Mercier
    Département de Biochimie and Groupe de Recherche sur le Système Nerveux Autonome, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 277:44925-31. 2002
    ....
  22. ncbi Differences in endosomal targeting of human (beta)1- and (beta)2-adrenergic receptors following clathrin-mediated endocytosis
    Wei Liang
    Membrane Biochemistry Section, Laboratory of Molecular and Cellular Neurobiology, National Institute of Neurological Disorders and Stroke, The National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 117:723-34. 2004
    ..But during or after endocytosis, beta(1)AR and beta(2)AR are sorted into different endosomal compartments...
  23. ncbi Golgin-160 promotes cell surface expression of the beta-1 adrenergic receptor
    Stuart W Hicks
    Department of Cell Biology, Johns Hopkins University School of Medicine, 725 Wolfe Street, Baltimore, MD 21205, USA
    Traffic 7:1666-77. 2006
    ..leads to significantly decreased cell surface levels of exogenously expressed beta1-adrenergic receptor (beta1AR), which can be rescued by expression of RNAi-resistant forms of golgin-160...
  24. pmc A pilot study of the pharmacodynamic impact of SSRI drug selection and beta-1 receptor genotype (ADRB1) on cardiac vital signs in depressed patients: a novel pharmacogenetic approach
    Kelan L H Thomas
    University of Michigan, Ann Arbor, MI, USA
    Psychopharmacol Bull 43:11-22. 2010
    The adrenergic beta-1 receptor gene (ADRB1) Ser49Gly and Arg389Gly variants differentially affect blood pressure response to beta-blocker therapy...
  25. ncbi Beta1-adrenoceptor gene variations: a role in idiopathic dilated cardiomyopathy?
    S Podlowski
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    J Mol Med (Berl) 78:87-93. 2000
    ..The present results may provide a clue on the molecular mechanisms involved in IDCM, and add moreover interesting information on nature, distribution, and evolutionary aspects of sequence variation in human adrenergic receptor genes...
  26. pmc A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate
    Koustubh Ranade
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Am J Hum Genet 70:935-42. 2002
    ..Neither the Arg389Gly polymorphism in the beta1 adrenergic receptor nor polymorphisms in the beta2 and beta3 adrenergic receptors were associated with resting heart rate. The heritability of heart rate was 39.7% +/- 7.1% (P<10-7)...
  27. ncbi The genetic determination of left ventricular mass in healthy adults
    L Swan
    Department of Medicine and Therapeutics, University of Glasgow, UK
    Eur Heart J 24:577-82. 2003
    ..The aim of this study was to assess the heritability of LV mass and its association with three potential candidate genes...
  28. ncbi Genetic variations associated with echocardiographic left ventricular traits in hypertensive blacks
    Kristin J Meyers
    Department of Epidemiology, University of Michigan, Ann Arbor, USA
    Hypertension 49:992-9. 2007
    ..One in the ADRB1 gene was significantly associated with relative wall thickness with replicate effects in both samples...
  29. doi Genetic variation within the beta1-adrenergic receptor gene results in haplotype-specific expression phenotypes
    Kersten M Small
    Merck Research Laboratories, Cardiovascular Diseases, Rahway, NJ, USA
    J Cardiovasc Pharmacol 51:106-10. 2008
    Cardiac beta1-adrenergic receptor (beta1AR) responsiveness in heart failure exhibits interindividual variation that may be attributable to polymorphisms of the intronless beta1AR gene...
  30. pmc Effect of the ADRB1 1165C>G and 145A>G polymorphisms on hemodynamic response during dobutamine stress echocardiography
    Anna Banas
    Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland
    Eur J Clin Pharmacol 67:477-82. 2011
    The aim of this study was to determine an association between the ADRB1 1165C>G and 145A>G polymorphisms and hemodynamic response [heart rate (HR), systolic (SBP) and diastolic (DBP) blood pressure] to dobutamine during dobutamine ..
  31. pmc Cloning of the cDNA for the human beta 1-adrenergic receptor
    T Frielle
    Department of Medicine Cardiology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710
    Proc Natl Acad Sci U S A 84:7920-4. 1987
    ..Mammalian beta 1AR and beta 2AR are thus products of distinct genes, both of which are apparently related to the putative G-21 receptor...
  32. ncbi Genetic mapping of adrenergic receptor genes in humans
    M R Hoehe
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    J Mol Med (Berl) 73:299-306. 1995
    ..mapped to the interval between D4S126 and D4S62; and the alpha 2-C10 (alpha 2A AR)/beta 1 haplotype (loci ADRA2A/ADRB1) mapped to the interval between D10S259 and D10S187...
  33. ncbi A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor
    D A Mason
    Departments of Medicine and Pharmacology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Biol Chem 274:12670-4. 1999
    The beta1-adrenergic receptor (beta1AR) is a key cell surface signaling protein expressed in the heart and other organs that mediates the actions of catecholamines of the sympathetic nervous system...
  34. ncbi Racial differences in the frequencies of cardiac beta(1)-adrenergic receptor polymorphisms: analysis of c145A>G and c1165G>C
    J D Moore
    Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0564, USA
    Hum Mutat 14:271. 1999
  35. ncbi A novel polymorphism in the gene coding for the beta(1)-adrenergic receptor associated with survival in patients with heart failure
    M Borjesson
    Wallenberg Laboratory for Cardiovascular Research, Department of Cardiology, Sahlgrenska University Hospital, Goteborg, Sweden
    Eur Heart J 21:1853-8. 2000
    ..No genetic polymorphism has previously been identified in the beta(1)-adrenergic receptor gene. The aim of this study was to find possible mutations in this gene and to relate such findings to morbidity and prognosis in heart failure...
  36. ncbi Polymorphism in the beta(1)-adrenergic receptor gene and hypertension
    K Bengtsson
    Department of Endocrinology, Malmo University Hospital, Lund University, Sweden
    Circulation 104:187-90. 2001
    ..4+/-9.9 versus 76.0+/-10.1 mm Hg; P=0.003) and higher heart rates (68.3+/-11.0 versus 65.1+/-9.4 bpm; P=0.02) than siblings carrying 1 or 2 copies of the Gly389 allele. The Ser49Gly polymorphism was not associated with hypertension...
  37. ncbi The Arg 389 Gly beta1-adrenergic receptor gene polymorphism and human fat cell lipolysis
    M Ryden
    Department of Medicine, Karolinska Institutet at Huddinge Hospital, Huddinge, Sweden
    Int J Obes Relat Metab Disord 25:1599-603. 2001
    ..The beta1-adrenoceptor is a candidate gene for obesity because of its role in catecholamine-induced energy homeostasis. A common Arg 389 Gly variant polymorphism has been shown in recombinant cells to influence its-coupling properties...
  38. ncbi Association between obesity and a polymorphism in the beta(1)-adrenoceptor gene (Gly389Arg ADRB1) in Caucasian women
    I J Dionne
    Clinical Pharmacology and Metabolic Research Unit, Department of Medicine, University of Vermont, Burlington, Vermont, USA
    Int J Obes Relat Metab Disord 26:633-9. 2002
    ..A putative gain-of-function polymorphism in the beta(1)-adrenoceptor was recently discovered (Gly389Arg ADRB1)...
  39. ncbi An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals at risk of coronary events. A WOSCOPS substudy
    H L White
    Institute for Cardiovascular Research, University of Leeds, UK
    Eur Heart J 23:1087-92. 2002
    ..The aim of this study was to ascertain whether this Glycine389 variant protects against coronary events...
  40. ncbi Similarities and differences in the coupling of human beta1- and beta2-adrenoceptors to Gs(alpha) splice variants
    Katharina Wenzel-Seifert
    Department of Pharmacology and Toxicology, The University of Kansas, Malott Hall, Room 5064, 1251 Wescoe Hall Drive, Lawrence, KS 66045, USA
    Biochem Pharmacol 64:9-20. 2002
    The human beta1-adrenoceptor (beta1AR) and beta2-adrenoceptor (beta2AR) couple to Gs-proteins to activate adenylyl cyclase (AC)...
  41. ncbi Suppressive effect of the Gly389 allele of the beta1-adrenergic receptor gene on the occurrence of ventricular tachycardia in dilated cardiomyopathy
    Chikao Iwai
    Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
    Circ J 66:723-8. 2002
    ..29 ([95% confidence interval, 0.13-0.64], p=0.002), when compared with the Arg389 homozygotes. The Gly389 variant supressed the occurrence of VT in DCM, suggesting that this allele confers a decreased risk of sudden death...
  42. ncbi Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure
    Kersten M Small
    Division of Pulmonary Medicine, University of Cincinnati College of Medicine, Cincinnati 45267 0564, USA
    N Engl J Med 347:1135-42. 2002
    ..We hypothesized that this combination of receptor variants, which results in increased synaptic norepinephrine release and enhanced receptor function at the myocyte, would predispose persons to heart failure...
  43. ncbi Polymorphisms of the beta1-adrenergic receptor predict exercise capacity in heart failure
    Lynne E Wagoner
    Department of Cardiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0564, USA
    Am Heart J 144:840-6. 2002
    ..in patients with congestive heart failure is partially dependent on cardiac beta1-adrenergic receptor (beta1AR) function...
  44. ncbi Variation at the beta-1 adrenoceptor gene locus affects left ventricular mass in renal failure
    Tony Stanton
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Gardiner Institute, Western Infirmary, Scotland, UK
    J Nephrol 15:512-8. 2002
    To examine the relationship between this variation in the beta1AR gene and the effect on LV mass.
  45. ncbi A common beta1-adrenergic receptor polymorphism (Arg389Gly) affects blood pressure response to beta-blockade
    G G Sofowora
    Division of Clinival Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 373232 6602, USA
    Clin Pharmacol Ther 73:366-71. 2003
    ..A common polymorphism of the beta(1)-adrenergic receptor Arg389Gly markedly affects function in vitro, but little is known about its in vivo significance...
  46. ncbi Arg389Gly polymorphism of the human beta1-adrenergic receptor in patients with nonfatal acute myocardial infarction
    Chikao Iwai
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Am Heart J 146:106-9. 2003
    We sought to investigate the relation between the Arg389Gly polymorphism in the human beta1-adrenergic receptor (ADRB1) gene and acute myocardial infarction (AMI)...
  47. ncbi An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals with heart failure: a MERIT-HF sub-study
    Hazel L White
    Institute for Cardiovascular Research, University of Leeds, Leeds, UK
    Eur J Heart Fail 5:463-8. 2003
    The Glycine389 variant of the beta-1 adrenergic receptor (beta1AR) generates markedly less cAMP when stimulated in vitro than the more prevalent Arginine389 variant.
  48. ncbi Association between hypertension and the alpha-adducin, beta1-adrenoreceptor, and G-protein beta3 subunit genes in the Japanese population; the Suita study
    Keisuke Shioji
    Department of Epidemiology, Research Institute, National Cardiovascular Center, Suita, Japan
    Hypertens Res 27:31-7. 2004
    ..that have previously been implicated in hypertension: the alpha-adducin (ADD1/Gly460Trp), beta1-adrenoreceptor (ADRB1/Arg389Gly), and G-protein beta3 subunit (GNB3/C825T) gene polymorphisms...
  49. ncbi Role of beta1- and beta2-adrenoceptor polymorphisms in heart failure: a case-control study
    Loredana Covolo
    Cattedra di Igiene, Universita di Brescia, Italy
    Eur Heart J 25:1534-41. 2004
    ..We therefore compared the polymorphisms of the beta1-adrenoceptor gene (Arg389Gly), the beta2-adrenoceptor gene (Arg16Gly, Gln27Glu) and their combinations in patients with HF and normal subjects living in the same area...
  50. ncbi Association of beta-adrenergic receptor polymorphisms and progression to heart failure in patients with idiopathic dilated cardiomyopathy
    Cinzia Forleo
    Institute of Cardiology, University of Bari, Bari, Italy
    Am J Med 117:451-8. 2004
    ..We assessed the effects of beta-adrenergic receptor variants on heart failure in idiopathic dilated cardiomyopathy...
  51. ncbi Interaction between cardiac sympathetic drive and heart rate in heart failure: modulation by adrenergic receptor genotype
    David M Kaye
    Wynn Department of Metabolic Cardiology, Baker Heart Research Institute, Melbourne, Vic, Australia
    J Am Coll Cardiol 44:2008-15. 2004
    ....
  52. ncbi The Arg389Gly beta1-adrenoceptor gene polymorphism determines contractile response to catecholamines
    Karl La Rosee
    Klinik III fur Innere Medizin, Universitat zu Koln, Germany
    Pharmacogenetics 14:711-6. 2004
    Recently, the Arg389Gly beta1-adrenoceptor (beta1AR) gene polymorphism has been detected. The Arg variant exhibited increased responsiveness to agonist-induced stimulation in vitro...
  53. ncbi Association between beta-1 and beta-2 adrenergic receptor gene polymorphisms and the response to beta-blockade in patients with stable congestive heart failure
    Pascal de Groote
    Service de Cardiologie C, Hopital Cardiologique, Centre Hospitalier Universitaire de Lille, Lille, France
    Pharmacogenet Genomics 15:137-42. 2005
    ..Heart rate and LVEF responses to beta-blockade were not associated with the beta1AR or the beta2AR polymorphisms...
  54. ncbi Beta1-adrenergic receptor polymorphisms and left ventricular remodeling changes in response to beta-blocker therapy
    Steven G Terra
    Department of Pharmacy Practice, University of Florida College of Pharmacy, Gainesville, FL 32610, USA
    Pharmacogenet Genomics 15:227-34. 2005
    ..We hypothesized that polymorphisms at codon 389 (Arg389Gly) and 49 (Ser49Gly) in the beta1-adrenergic receptor (AR) gene were associated with LV reverse remodeling changes in response to beta-blocker therapy among heart failure patients...
  55. ncbi Association between beta-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: a report from the NHLBI-sponsored WISE study
    S G Terra
    Department of Pharmacy Practice, University of Florida College of Pharmacy, Gainesville, FL 32610, USA
    Int J Obes (Lond) 29:746-54. 2005
    ..Objective is to determine the association between obesity and polymorphisms in genes of the beta(1)AR (ADRB1), beta(2)AR (ADRB2), beta(3)AR (ADRB3), Gs protein alpha (GNAS1), to which all three beta-receptors couple and the ..
  56. ncbi Ser49Gly of beta1-adrenergic receptor is associated with effective beta-blocker dose in dilated cardiomyopathy
    Yvonne Magnusson
    Wallenberg Laboratory for Cardiovascular Research and Department of Primary Health Care, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Clin Pharmacol Ther 78:221-31. 2005
    ..Our objective was to evaluate the influence of polymorphisms at codons 49 and 389 of the beta1-adrenergic receptor (beta1-AR) on the response to beta-blockers and outcome in patients with dilated cardiomyopathy...
  57. pmc No positive association between adrenergic receptor variants of alpha2cDel322-325, beta1Ser49, beta1Arg389 and the risk for heart failure in the Japanese population
    Shinpei Nonen
    Department of Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    Br J Clin Pharmacol 60:414-7. 2005
    ..We investigated the correlation of adrenergic receptor polymorphisms, alpha(2c)Del322-325, beta(1)Ser49Gly and beta(1)Arg389Gly, with the risk of heart failure in the Japanese population...
  58. ncbi Beta2-adrenergic receptor genotype and survival among patients receiving beta-blocker therapy after an acute coronary syndrome
    David E Lanfear
    Departments of Medicine, Genetics, and Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO
    JAMA 294:1526-33. 2005
    Previous data support an association between polymorphisms of the beta1- and beta2-adrenergic receptors (ADRB1 and ADRB2) and surrogate end points of response to beta-adrenergic blocker therapy...
  59. ncbi Effects of polymorphisms in beta1-adrenoceptor and alpha-subunit of G protein on heart rate and blood pressure during exercise test. The Finnish Cardiovascular Study
    Tuomo Nieminen
    Dept of Pharmacological Sciences, Medical School, Univ of Tampere, Tampere FI 33014, Finland
    J Appl Physiol (1985) 100:507-11. 2006
    We tested whether the Arg389Gly and Ser49Gly polymorphisms of the beta1-adrenergic receptor gene ADRB1 and the T393C polymorphism of the G protein alpha-subunit gene GNAS1 modulate heart rate (HR) and blood pressure responses during an ..
  60. ncbi The impact of beta-adrenoreceptor gene polymorphisms on survival in patients with congestive heart failure
    Pascal de Groote
    Service de Cardiologie C, Hopital Cardiologique, Centre Hospitalier Regional et Universitaire de Lille, Boul Prof J Leclercq, 59037 Lille Cedex, France
    Eur J Heart Fail 7:966-73. 2005
    ..The aim of the study was to analyze the impact of five functional betaAR gene polymorphisms in patients with stable CHF...
  61. ncbi Beta1-adrenergic receptor gene polymorphisms in Mexican patients with idiopathic dilated cardiomyopathy
    José Manuel Fragoso
    Department of Physiology, Cardiovascular Disease s Genomic and Proteomic Study Group, Instituto Nacional de Cardiologia Ignacio Chavez, Tlalpan 14080, Mexico City, Mexico
    Exp Mol Pathol 80:279-82. 2006
    ..16) and *Arg/*Gly genotype (pC = 0.027, OR = 2.70) in the group of IDC patients when compared to healthy controls. The data suggest that Arg389Gly polymorphism could be involved in the genetic susceptibility to develop IDC in Mexicans...
  62. pmc A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure
    Stephen B Liggett
    Department of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 103:11288-93. 2006
    ..We conclude that beta(1)AR-389 variation alters signaling in multiple models and affects the beta-blocker therapeutic response in HF and, thus, might be used to individualize treatment of the syndrome...
  63. ncbi Adrenergic receptor polymorphisms associated with resting heart rate: the HyperGEN Study
    J B Wilk
    Boston University School of Medicine, MA 02118, USA
    Ann Hum Genet 70:566-73. 2006
    The association between polymorphisms in the beta1, beta2 and alpha2B adrenergic receptor (ADR) genes (ADRB1, ADRB2 and ADRA2B) and resting heart rate was examined in white and African-American participants of the HyperGEN Study...
  64. ncbi Relation of beta(2)-adrenoceptor haplotype to risk of death and heart transplantation in patients with heart failure
    Jaekyu Shin
    College of Pharmacy, Gainesville, Florida, USA
    Am J Cardiol 99:250-5. 2007
    ..Eight polymorphisms in 6 genes were genotyped: beta(1)-adrenergic receptor (ADRB1, S49G, R389G), beta(2)-adrenergic receptor (ADRB2, G16R, Q27E), alpha(2c)-adrenergic receptor (ADRA2C, insertion/..
  65. ncbi Studies of associations between the Arg389Gly polymorphism of the beta1-adrenergic receptor gene (ADRB1) and hypertension and obesity in 7677 Danish white subjects
    A P Gjesing
    Steno Diabetes Center, Gentofte, Denmark
    Diabet Med 24:392-7. 2007
    Activation of the beta(1)-adrenergic receptor (ADRB1) causes increased lipolysis in adipose tissue and enhances cardiac output...
  66. ncbi Synergistic polymorphisms of beta1 and alpha2C-adrenergic receptors and the influence on left ventricular ejection fraction response to beta-blocker therapy in heart failure
    Maximilian T Lobmeyer
    Department of Pharmacy Practice, University of Florida, Gainesville, FL 32610, USA
    Pharmacogenet Genomics 17:277-82. 2007
    The Arg389Gly polymorphism (Arg389Gly) in the beta1-adrenergic receptor gene (ADRB1) has been associated with improvement in left-ventricular remodeling with beta-blocker treatment...
  67. ncbi Beta1- and beta2-adrenergic receptor polymorphisms affect susceptibility to idiopathic dilated cardiomyopathy
    Cinzia Forleo
    Institute of Cardiology, University of Bari, Bari, Italy
    J Cardiovasc Med (Hagerstown) 8:589-95. 2007
    ..We investigated whether functionally relevant polymorphisms within the genes encoding for these receptors indicate susceptibility to idiopathic dilated cardiomyopathy (DCM)...
  68. ncbi Association of beta-adrenoceptor polymorphisms with cardiac autonomic modulation in Japanese males
    Tetsuro Matsunaga
    Laboratory of Metabolism, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan
    Am Heart J 154:759-66. 2007
    ..Several functional genetic variations in the beta-AR genes (ADRB1 or ADRB2) have been identified and implicated as causes of hypertension and cardiovascular disease...
  69. ncbi Arg389Gly-beta1-adrenergic receptors determine improvement in left ventricular systolic function in nonischemic cardiomyopathy patients with heart failure after chronic treatment with carvedilol
    Lu Chen
    Department of Medicine, The University of Queensland, Brisbane, Queensland, Australia
    Pharmacogenet Genomics 17:941-9. 2007
    ..We aimed to determine whether these polymorphisms contribute to variability in response to carvedilol in patients with chronic heart failure...
  70. ncbi Role of beta adrenergic receptor polymorphisms in heart failure: systematic review and meta-analysis
    Amal Muthumala
    Centre for Cardiovascular Genetics, Rayne Institute, Royal Free and University College Medical School, London WC1E 6JF, UK
    Eur J Heart Fail 10:3-13. 2008
    ..In addition, a meta-analysis of three studies analysing the effect of ADRB1 Arg389Gly polymorphism on left ventricular remodelling with the use of beta blockers, demonstrating a 5% ..
  71. doi Association of beta 1-adrenergic receptor gene polymorphisms with left ventricular hypertrophy in human essential hypertension
    Chunyan Fu
    Sino German Laboratory for Molecular Medicine, Key Laboratory for Clinical Cardiovascular Genetics of Ministry of Education, Fuwai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences, 167 Beilishi Road, Beijing 100037, China
    Clin Biochem 41:773-8. 2008
    Experimental evidence support a key role for beta (1)-adrenergic receptor (ADRB1) in the modulation of cardiac mass. This relationship has not yet been described in Chinese population...
  72. doi Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol
    Amy J Sehnert
    CardioDx, Inc, Palo Alto, California 94303, USA
    J Am Coll Cardiol 52:644-51. 2008
    ..This study investigated the role of adrenergic receptor genetics on transplant-free survival in heart failure (HF)...
  73. doi Impact of beta1-adrenergic receptor polymorphisms on susceptibility to heart failure, arrhythmogenesis, prognosis, and response to beta-blocker therapy
    Andreia Biolo
    Heart Failure and Cardiac Transplant Unit, Cardiology Division, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Am J Cardiol 102:726-32. 2008
    ..A pharmacogenetic interaction is suggested because beta blockers were more effective in beta1-389Arg allele carriers...
  74. pmc Beta1- and alpha2c-adrenoreceptor variants as predictors of clinical aspects of dilated cardiomyopathy in people of African ancestry
    A J Woodiwiss
    Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Division of Cardiology, Chris Hani Baragwanath Hospital and University of the Witwatersrand, Johannesburg
    Cardiovasc J Afr 19:188-93. 2008
    ....
  75. ncbi Polymorphisms of the beta-1 and beta-2 adrenergic receptors in Polish patients with idiopathic dilated cardiomyopathy
    Aleksandra Paczkowska
    Department of Molecular Biology, Institute of Cardiology, Warsaw, Poland
    Kardiol Pol 67:235-41. 2009
    ..The beta-adrenergic receptor pathway is altered in heart failure. Recent studies have discovered functionally relevant and common polymorphisms in both b1-AR and b2-AR...
  76. doi Effect of 393T>C polymorphism of GNAS1 gene on dobutamine response in Chinese healthy subjects
    Yan Mei Mao
    Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, Changsha, Hunan 410078, People s Republic of China
    J Clin Pharmacol 49:929-36. 2009
    ..9% +/- 4.0% vs 36.4% +/- 2.1%; 95% CI, 18.8%-38.9%; P = .046). These data suggested that the 393T>C polymorphism of GNAS1 was functionally relevant in vivo...
  77. pmc Clinical and genetic modifiers of long-term survival in heart failure
    Sharon Cresci
    Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Am Coll Cardiol 54:432-44. 2009
    ..This study sought to identify genetic modifiers of beta-blocker response and long-term survival in heart failure (HF)...
  78. doi Polymorphisms of the beta1-adrenergic receptor gene are associated with essential hypertension in Chinese
    Yingxin Peng
    Cardiac Center, Hebei Provincial People s Hospital, Shijiazhuang, People s Republic of China
    Clin Chem Lab Med 47:1227-31. 2009
    The beta1-adrenergic receptor (ADRB1) plays a pivotal role in mediating signal transduction of the sympathetic-adrenal system, which is involved in the regulation of cardiac output and peripheral resistance...
  79. doi Polymorphisms of beta-adrenoceptor and natriuretic peptide receptor genes influence the susceptibility to and the severity of idiopathic dilated cardiomyopathy in a Chinese cohort
    Lingjie Wang
    Department of Cardiology, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People s Republic of China
    J Card Fail 16:36-44. 2010
    ..This study evaluated the potential effects of beta-adrenoceptor (beta-AR) and natriuretic peptide receptor (NPR) gene polymorphisms on the susceptibility to and the severity of idiopathic dilated cardiomyopathy (IDCM) in a Chinese cohort...
  80. doi Role of beta-adrenergic receptor gene polymorphisms in the long-term effects of beta-blockade with carvedilol in patients with chronic heart failure
    Marco Metra
    Institute of Cardiology, Department of Experimental and Applied Medicine, University of Brescia, Italy
    Cardiovasc Drugs Ther 24:49-60. 2010
    ..Beta-adrenergic receptors (AR) single nucleotide gene polymorphisms (SNPs) may influence the sensitivity and density of beta-AR. We assessed the relation between three common beta-AR SNPs and the response to carvedilol administration...
  81. doi Association of ADRB1 gene polymorphism with atrial fibrillation
    Svetlana Nicoulina
    Krasnoyarsk State Medical University, Krasnoyarsk, Russia
    Genet Test Mol Biomarkers 14:249-53. 2010
    ..study was to establish the probability and patterns of atrial fibrillation (AF) inheritance in families, and to find an association of primary and secondary AF with polymorphism Ser49Gly of the gene encoding beta1-adrenoreceptor (ADRB1).
  82. doi The Arg16Gly-β(2)-adrenoceptor single nucleotide polymorphism: exercise capacity and survival in patients with end-stage heart failure
    Kirsten Leineweber
    Institute for Pathophysiology, University of Duisburg Essen School of Medicine, Essen, Germany
    Naunyn Schmiedebergs Arch Pharmacol 382:357-65. 2010
    ..In conclusion, the Arg16Gly-β(2)AR might impact on exercise capacity and outcome in end-stage heart failure...
  83. doi A meta-analysis of β1-adrenergic receptor gene polymorphisms in idiopathic dilated cardiomyopathy
    Bo Jin
    Department of Cardiology, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, China
    Mol Biol Rep 39:563-7. 2012
    ..33-15.15; Ph=0.12), but not among Europeans. In summary, this meta-analysis suggests that no statistically increased risk was found between β1-adrenergic receptor gene polymorphisms and susceptibility to IDCM among Europeans...
  84. doi Polymorphisms of the beta adrenergic receptor predict left ventricular remodeling following acute myocardial infarction
    Rhondalyn C McLean
    Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Cardiovasc Drugs Ther 25:251-8. 2011
    ..This study was undertaken to explore the relationship between LV remodeling after myocardial infarction and polymorphisms in the cardiac β1-AR and β2-AR genes...
  85. pmc A common β1-adrenergic receptor polymorphism predicts favorable response to rate-control therapy in atrial fibrillation
    Babar Parvez
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37323, USA
    J Am Coll Cardiol 59:49-56. 2012
    ..In this study, we evaluated the impact of 2 common β1-adrenergic receptor (β1-AR) polymorphisms (G389R and S49G) in response to ventricular rate control therapy in patients with atrial fibrillation (AF)...
  86. ncbi [Polymorphisms of Arg389Gly of β1-adrenergic receptor gene and essential hypertension risk: a meta analysis]
    Ya Jie Li
    Dalian Municipal Central Hospital, Dalian, China
    Zhonghua Yi Xue Za Zhi 91:3115-9. 2011
    ..To evaluate the associations between polymorphisms Arg389Gly of β1-adrenergic receptor gene and essential hypertension risk...
  87. ncbi [Beta1-adrenergic receptor (Arg389Gly) polymorphism and response to bisoprolol in patients with chronic heart failure]
    Wen ping Yu
    Department of Cardiology, Tongji Hospital, Tongji University, Shanghai 200065, China
    Zhonghua Xin Xue Guan Bing Za Zhi 34:776-80. 2006
    ....
  88. ncbi Beta-1-adrenergic receptor gene in major depression: influence on antidepressant treatment response
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 120:85-9. 2003
    ..05). However, after correction for multiple testing (Bonferroni) these results did not remain significant. Nevertheless, these findings suggest that the presence of the C allele might be an indicator for antidepressant treatment response...
  89. ncbi Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol
    Julie A Johnson
    Department of Pharmacy Practice, College of Pharmacy, University of Florida, Gainesville, 32610, USA
    Clin Pharmacol Ther 74:44-52. 2003
    ..We tested the hypothesis that 2 common polymorphisms in the gene for beta(1)-adrenergic receptor are associated with antihypertensive response to metoprolol in patients with uncomplicated hypertension...
  90. ncbi Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure
    Jeanne Mialet Perez
    Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Nat Med 9:1300-5. 2003
    ....
  91. ncbi Gly389Arg polymorphism of beta1-adrenergic receptor is associated with the cardiovascular response to metoprolol
    Jie Liu
    Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, China
    Clin Pharmacol Ther 74:372-9. 2003
    ....
  92. ncbi Modifying effects of the R389G beta1-adrenoceptor polymorphism on resting heart rate and blood pressure in patients with obstructive sleep apnoea
    Jan Borgel
    Medical Clinic 2, Cardiology and Angiology, St Josef Hospital Bergmannsheil, Ruhr University, Bochum, Germany
    Clin Sci (Lond) 110:117-23. 2006
    ..2) beats/min for G389G]. In conclusion, although the R389G polymorphism of the beta1-adrenoceptor gene did not influence resting HR or BP in untreated OSA patients, it may modify the beneficial effects of CPAP therapy on these parameters...
  93. ncbi Mechanisms of beta-adrenergic receptor-mediated venodilation in humans
    Christoph Schindler
    Institute of Clinical Pharmacology, Medical Faculty, Dresden University of Technology, Germany
    Clin Pharmacol Ther 75:49-59. 2004
    ..This study was designed to elucidate the underlying mechanisms of isoproterenol (INN, isoprenaline)-induced venodilation by investigation of dorsal hand vein responses...
  94. ncbi Fenoterol but not dobutamine increases erythropoietin production in humans
    C H Gleiter
    Abteilung Klinische Pharmakologie, Universitat Gottingen, Germany
    Clin Pharmacol Ther 61:669-76. 1997
    ..This study assessed the role of adrenergic signal transmission in the control of renal erythropoietin (EPO) production in humans...
  95. pmc Betaxolol, a selective beta(1)-adrenergic receptor antagonist, diminishes anxiety-like behavior during early withdrawal from chronic cocaine administration in rats
    C A Rudoy
    Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:1119-29. 2007
    ....
  96. ncbi [The effects of combined beta(1) adrenergic receptor antagonist and beta(2) adrenergic receptor agonist therapy on cardiac function and myocardial apoptosis in heart failure rats]
    Wei Min Li
    Department of Cardiology, First Clinical Hospital, Harbin Medical University, Harbin 150001, China
    Zhonghua Xin Xue Guan Bing Za Zhi 35:615-9. 2007
    ..To observe the effects of combined beta(1) adrenergic receptor (AR) antagonist with beta(2)AR agonist therapy on cardiac function and cardiomyocyte apoptosis in heart failure rats...
  97. ncbi Molecular cloning and expression of the rat beta 1-adrenergic receptor gene
    C A Machida
    Division of Neuroscience, Oregon Regional Primate Research Center, Beaverton 97006
    J Biol Chem 265:12960-5. 1990
    ....
  98. ncbi [Serum autoantibodies against the cardiac beta(1)-adrenergic receptor in patients with chronic heart failure: clinical characteristics and response to carvedilol]
    Jin Chen
    Heart Centre, Beijing Chaoyang Hospital, Capital University of Medical Sciences, Beijing 100020, China
    Zhonghua Xin Xue Guan Bing Za Zhi 35:599-602. 2007
    ..To detect the serum autoantibodies against the cardiac beta(1)-adrenergic receptor and observe the clinical characteristics and response to carvedilol use in patients with chronic heart failure (CHF)...
  99. ncbi Benidipine stimulates nitric oxide synthase and improves coronary circulation in hypertensive rats
    N Kobayashi
    Department of Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Am J Hypertens 12:483-91. 1999
    ..LV) and its relation to coronary flow reserve, and microvascular remodeling in renovascular hypertensive rats (RHR: 2K-1C Goldblatt). Benidipine (5 mg/kg/day) was given to RHR (B-RHR, n = 11) for 6 weeks...
  100. ncbi Autoimmunity against the second extracellular loop of beta(1)-adrenergic receptors induces early afterdepolarization and decreases in K-channel density in rabbits
    Yukiko Fukuda
    Cardiopulmonary Division of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi Shinjuku ku, Tokyo 160 8582, Japan
    J Am Coll Cardiol 43:1090-100. 2004
    ..We sought to define the electrophysiologic property of the rabbit heart associated with autoimmunity against the second extracellular loop of the beta(1)-adrenergic receptor...
  101. pmc Evidence for beta1-adrenergic receptor involvement in amygdalar corticotropin-releasing factor gene expression: implications for cocaine withdrawal
    CARLA A RUDOY
    Department of Neurosurgery, Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Neuropsychopharmacology 34:1135-48. 2009
    ....

Research Grants52

  1. PKA targeting: A novel mechanism for GPCR resensitization
    SULEIMAN WAKIM BAHOUTH; Fiscal Year: 2012
    ..By investigating the function of these networks, we believe that we can improve on the performance of beta-blockers, which are widely-used in treating two major health problems in America, namely hypertension and heart failure. ..
  2. Atrial Fibrillation in Hyperthyroidism: Active Antibodies to Autonomic Receptors
    DAVID KEM; Fiscal Year: 2013
    ..and atrial fibrillation (AF) have coexisting activating autoantibodies (AA) to the beta1-adrenergic (B1AR) and M2 muscarinic receptors (M2R)...
  3. Virtual screening studies of the Beta-2 Adrenergic Receptor
    Dahlia R Weiss; Fiscal Year: 2012
    ..The B2-adrenergic receptor (B2AR) is responsible for the relaxation of vascular, uterine and airway smooth muscle. B1AR antagonists ("beta-blockers") are widely used in cardiovascular therapy for the treatment of angina, arrhythmias, ..
  4. Howard A Rockman; Fiscal Year: 2016
    ..In contrast, activation of b1AR appears to exert a primarily adverse influence on post myocardial infarction (MI) cardiac remodeling...
  5. Beta-Adrenergic Receptor Modulation of Insulin Signaling
    Robert Walker; Fiscal Year: 2012
    ..Since diabetic patients often require insulin treatment, it is critical to determine the regulation of cellular events in the retina following insulin and other treatments. ..
  6. Endothelial BK Channel Regulation by Caveolae Targeting
    Hon Chi Lee; Fiscal Year: 2010
    ..3) beta2-Adrenergic receptors (beta2AR) are targeted to endothelial caveolae and are more efficient than beta1AR in regulating BK channel function...
  7. DOUGLAS TILLEY; Fiscal Year: 2016
    ..These studies will provide novel insight into how the [unreadable]1AR-EGFR complex exerts cardioprotection, identifying key signaling pathways for development of an improved molecular approach to heart failure therapy. ..
  8. Targeting and Function of Golgi Membrane Proteins
    Carolyn E Machamer; Fiscal Year: 2011
    ..The proposed experiments on golgin-160 will add to our understanding of cargo delivery to the cell surface and to the role of the Golgi complex in transducing stress signals to the rest of the cell. ..
  9. bZIP Repression of Adrenergic Receptor RNA in Neurons
    CURTIS MACHIDA; Fiscal Year: 2006
    ..My laboratory has examined the molecular mechanisms underlying beta1AR mRNA down-regulation following agonist induction, and have identified potential transcriptional and post-..
  10. Transcription & Function of Adipocyte Beta3AR in Obesity
    Sheila Collins; Fiscal Year: 2006
    ..in this aim will also test the hypothesis that alterations in the profile of C/EBP proteins contribute to the obesity/diabetes dependent down-regulation of expression of the beta3AR and beta1AR genes in adipocytes.
  11. Adrenergic Modulation of Trigeminal Nociceptors
    Jose Vela; Fiscal Year: 2007
    ..Our preliminary results indicate that the mRNA encoding the beta1AR and identified beta1 receptor binding sites are present at greater levels in trigeminal ganglia (TGG) neurons ..
  12. MAGI-2 IN BETA-1-ADRENERGIC RECEPTOR FUNCTION
    Randy Hall; Fiscal Year: 2004
    The beta1-adrenergic receptor (beta1AR) is a G protein-coupled receptor that mediates many of the physiological effects of adrenaline and noradrenaline...
  13. Direct Interaction of GABA-A & Beta-Adrenergic Receptors
    JEREMY TEISSERE; Fiscal Year: 2003
    ..further immunoprecipitation studies, we propose to identify the specific amino acids in both the GABAAR and the beta1AR that mediate interaction...
  14. C-IV in Beta-1 AR coupling to G-protein
    NOEL DELOS SANTOS; Fiscal Year: 2004
    ..This study focuses on an important area of sympathetic innervation which is relevant to hypertension, fluid homeostasis, and renal disease progression. ..
  15. STRUCTURAL BASIS OF BETA1-ADRENERGIC RECEPTOR FUNCTION
    Stuart Green; Fiscal Year: 1999
    ..shown that significant functional differences exist between betaAR subtypes, and in particular between the beta1AR and beta2AR...
  16. BETA-ADRENERGIC RECEPTOR POLYMORPHISMS AND HYPERTENSION
    Julie Johnson; Fiscal Year: 2003
    ..They will test the hypotheses that the B1AR and/or B2AR genes: 1) are associated with HTN and racial differences in HTN; 2) influence the nocturnal blood ..
  17. Hypertension Pharmacogenetics
    Julie Johnson; Fiscal Year: 2006
    ..The proposed studies should add substantial new information about antihypertensive pharmacogenetics, and could influence how antihypertensive medications are prescribed in the future. ..
  18. Beta-receptors and cardiovascular pharmacogenomics
    Julie Johnson; Fiscal Year: 2006
    ..These studies are focused on testing the hypotheses that certain polymorphisms of the beta1AR are associated with relatively poor initial tolerability of beta-blockers, and also with the most dramatic ..
  19. Beta-adrenoceptor genetic polymorphisms and obesity
    Julie Johnson; Fiscal Year: 2002
    ..Specifically, we will be studying the association between obesity and genes of the beta1AR (ADRB1), the beta2AR (ADRB2), the beta3AR (ADRB3), the Gs protein alpha subunit (GNAS1) (all three betaARs couple ..
  20. Cocaine effects on norepinephrine in amygdala
    Carla Rudoy; Fiscal Year: 2007
    ..1995) and the stress-induced relapse to cocaine use (Lu et al., 2001) may be mediated by the effects of cocaine on noradrenergic circuits originating from brainstem nuclei (e.g. locus coeruleus) to the amygdala. ..
  21. Genetics of Chronic Kidney Disease
    Stephen T Turner; Fiscal Year: 2010
    ..abstract_text> ..
  22. Genome-wide association of common alleles with long-term diabetic complications
    Andrew Paterson; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  23. Renal 11b-Hydroxysteroid Dehydrogenases and Hypertension
    Mingyu Liang; Fiscal Year: 2008
    ..The results are expected to elucidate a novel aspect of the pathophysiology of salt- sensitive hypertension and to provide potential new targets for prevention and treatment of hypertension. ..
  24. Saliva and Salivary Gland Function Research Conference
    JAMES MELVIN; Fiscal Year: 2008
    ..It is the goal of the organizing team to encourage both growth and enrichment of this important field and to stimulate new strategies for studying salivary glands. [unreadable] [unreadable] [unreadable]..
  25. Genomic Predictors of Arteriosclerosis in Hypertensives
    Sharon Kardia; Fiscal Year: 2009
    ..End of Abstract) ..
  26. CYTOSTATIC ROLE OF THE ARGININE-NITRIC OXIDE PATHWAY
    Louis Ignarro; Fiscal Year: 2001
    ..The proposed research should advance our understanding of the biological role of NO synthase in regulating cell proliferation. ..
  27. MECHANISMS OF ANION TRANSPORT IN SALIVARY GLANDS
    James E Melvin; Fiscal Year: 2010
    ..This multidisciplinary approach will define the essential CI" transport mechanisms involved in the production of saliva, which is necessary for addressing the challenge of treating salivary gland dysfunction. ..
  28. Familial Dilated Cardiomyopathy:Genetic Characterization
    Matthew Taylor; Fiscal Year: 2006
    ..In addition, a diverse collection of consultants has been assembled to provide ongoing expertise that is sensitive to the needs of both the research and career development plans of the candidate. ..
  29. Myocardial Adenosine Receptors
    James G Dobson; Fiscal Year: 2010
    ..Such information should be instrumental for the development of new therapies and agents to alleviate cardiac dysfunction. ..
  30. Genetics of Microangiopathic Brain Injury
    Stephen T Turner; Fiscal Year: 2010
    ..abstract_text> ..
  31. Genetic studies on models of nuclear cataracts
    D Sidjanin; Fiscal Year: 2009
    ..Specific Aim (4): Once genes and mutations responsible for the Coc and Lop4 phenotypes are identified, the focus will be on characterizing the process of cataract development at the molecular level. ..
  32. LEUKOTRIENE POLYMORPHISMS & MONTELUKAST RESPONSE
    John Lima; Fiscal Year: 2003
    ..This information may lead to individualization of asthma medications based on the genetic make-up of the patient. ..
  33. REGULATION OF EXPRESSION OF NO SYNTHASE
    Louis Ignarro; Fiscal Year: 2002
    ..The proposed research represents a continuing long-term effort to elucidate the biological factors influencing the vascular and related actions of NO in health and disease. ..
  34. The Future of Salivary Gland Research
    JAMES MELVIN; Fiscal Year: 2003
    ....
  35. SES, health behaviors and CVD among Vietnam-era-Twins
    Jeanne McCaffery; Fiscal Year: 2005
    ..The primary method of analysis will be twin structural equation modeling. ..
  36. ADENOSINE A1 AND A2 RECEPTORS IN THE MYOCARDIUM
    James Dobson; Fiscal Year: 2004
    ..Additionally, the findings should significantly contribute to our basic knowledge of the molecular mechanisms of G protein coupled receptor cross-regulation in the heart. ..
  37. PROTEASE-ACTIVATED RECEPTOR ACTIONS IN CARDIOMYOCYTES
    Susan Steinberg; Fiscal Year: 2004
    ....
  38. VENTRICULAR DYSFUNCTION AFTER SUBARACHNOID HEMORRHAGE
    Jonathan Zaroff; Fiscal Year: 2004
    ..abstract_text> ..
  39. The effects of androgens on calcium homeostasis in card*
    Kish Golden; Fiscal Year: 2004
    ..The results of these experiments will shed light into the role of androgens in regulating cardiac contractile function...
  40. GENETIC DETERMINANTS OF HIGH BP IN THREE RACIAL GROUPS
    Sharon Kardia; Fiscal Year: 2004
    ..The resulting synthesis of ideas and amassed data permits rigorous hypothesis testing not otherwise possible and will hasten understanding of the previously elusive genetic variation responsible for disease risk. ..
  41. Genetic Predictors of Incident CVD
    Sharon Kardia; Fiscal Year: 2005
    ..abstract_text> ..
  42. 2005 Salivary Glands & Exocrine Secretion
    JAMES MELVIN; Fiscal Year: 2005
    ..It is the goal of the organizing team to encourage both growth and enrichment of this important field and to stimulate new strategies for studying salivary glands. ..
  43. b1-/b2-Adrenergic Receptor Mechanisms in Cardiomyocytes
    Susan Steinberg; Fiscal Year: 2007
    ..As such, these studies are likely to suggest novel clinical strategies that might be pursued (or should be avoided) for the management of chronic heart failure in humans. ..
  44. Fetal Coronary Vascular Responses to Long-term Hypoxia
    RAYMOND GILBERT; Fiscal Year: 2005
    ..Upon completion of the studies, we will have a better understanding of the alteration in fetal coronary artery contractility brought about by exposure to long-term hypoxemia. ..
  45. Genetic Predictors of Comorbid Depressive Symptoms + CAD
    Jeanne McCaffery; Fiscal Year: 2005
    ....
  46. PHARMACOGENETICS OF ASTHMA MONOTHERAPY
    John Lima; Fiscal Year: 2005
    ..The results of this pharmacogenetic study may facilitate the optimal selection of monotherapy in asthma. ..
  47. Risk factors for cardiac injury after SAH
    Jonathan Zaroff; Fiscal Year: 2006
    ..5. To test the hypothesis that SAH-induced cardiac dysfunction is associated with decreased systolic blood pressure and increased inpatient mortality. ..
  48. GENETIC EPIDEMIOLOGY OF RESPONSES TO ANTIHYPERTENSIVES
    Stephen Turner; Fiscal Year: 2006
    ....
  49. Anthipertensive PharmacoGenomics
    Stephen Turner; Fiscal Year: 2006
    ..abstract_text> ..
  50. Arginase and Nitric Oxide in Atherosclerosis
    Louis Ignarro; Fiscal Year: 2004
    ..The feasibility of this approach is borne out by the extensive preliminary data that support the central hypothesis. ..