ADRA2C

Summary

Gene Symbol: ADRA2C
Description: adrenoceptor alpha 2C
Alias: ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR, alpha-2C adrenergic receptor, adrenergic, alpha-2C-, receptor, alpha-2 adrenergic receptor subtype C4, alpha-2C adrenoceptor, alpha-2C adrenoreceptor, alpha-2CAR, alpha2-AR-C4
Species: human

Top Publications

  1. ncbi Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR
    V Chhajlani
    Department of Pharmacology, Umea University, Sweden
    FEBS Lett 280:241-4. 1991
  2. ncbi The additive effect of neurotransmitter genes in pathological gambling
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Clin Genet 60:107-16. 2001
  3. ncbi Regulation of alpha(2)-adrenoceptors in human vascular smooth muscle cells
    Maqsood A Chotani
    Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH 43210, USA
    Am J Physiol Heart Circ Physiol 286:H59-67. 2004
  4. ncbi Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure
    Kersten M Small
    Division of Pulmonary Medicine, University of Cincinnati College of Medicine, Cincinnati 45267 0564, USA
    N Engl J Med 347:1135-42. 2002
  5. pmc Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects
    Kersten M Small
    Departments of Medicine and Pharmacology and the CardioPulmonary Research Center, University of Cincinnati College of Medicine, Cincinnati, OH 45267
    Proc Natl Acad Sci U S A 101:13020-5. 2004
  6. ncbi Interaction between cardiac sympathetic drive and heart rate in heart failure: modulation by adrenergic receptor genotype
    David M Kaye
    Wynn Department of Metabolic Cardiology, Baker Heart Research Institute, Melbourne, Vic, Australia
    J Am Coll Cardiol 44:2008-15. 2004
  7. ncbi Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humans
    Alexander Neumeister
    Mood and Anxiety Disorders Program, Section on Experimental Therapeutics and Pathophysiology, NIMH, NIH, Bethesda, MD, USA
    Pharmacogenet Genomics 15:143-9. 2005
  8. pmc No positive association between adrenergic receptor variants of alpha2cDel322-325, beta1Ser49, beta1Arg389 and the risk for heart failure in the Japanese population
    Shinpei Nonen
    Department of Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    Br J Clin Pharmacol 60:414-7. 2005
  9. ncbi Alpha2C-adrenoceptor polymorphism is associated with improved event-free survival in patients with dilated cardiomyopathy
    Vera Regitz-Zagrosek
    DHZB, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur Heart J 27:454-9. 2006
  10. ncbi Effects of a alpha 2C-adrenoreceptor gene polymorphism on neural responses to facial expressions in depression
    Alexander Neumeister
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Neuropsychopharmacology 31:1750-6. 2006

Scientific Experts

Detail Information

Publications114 found, 100 shown here

  1. ncbi Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR
    V Chhajlani
    Department of Pharmacology, Umea University, Sweden
    FEBS Lett 280:241-4. 1991
    ..Our results demonstrate that the alpha 2-C4 adrenergic receptor exists in more than one copy in the human genome...
  2. ncbi The additive effect of neurotransmitter genes in pathological gambling
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Clin Genet 60:107-16. 2001
    ..Fifteen genes were included in the regression equation. The most significant were the DRD2, DRD4, DAT1, TPH, ADRA2C, NMDA1, and PS1 genes. The r(2) or fraction of the variance was less than 0.02 for most genes...
  3. ncbi Regulation of alpha(2)-adrenoceptors in human vascular smooth muscle cells
    Maqsood A Chotani
    Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH 43210, USA
    Am J Physiol Heart Circ Physiol 286:H59-67. 2004
    ..We found that alpha2C-ARs can be dramatically and selectively induced via a p38 MAPK-dependent pathway. Therefore, altered expression of alpha2C-ARs may contribute to pathological changes in vascular function...
  4. ncbi Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure
    Kersten M Small
    Division of Pulmonary Medicine, University of Cincinnati College of Medicine, Cincinnati 45267 0564, USA
    N Engl J Med 347:1135-42. 2002
    ..We hypothesized that this combination of receptor variants, which results in increased synaptic norepinephrine release and enhanced receptor function at the myocyte, would predispose persons to heart failure...
  5. pmc Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects
    Kersten M Small
    Departments of Medicine and Pharmacology and the CardioPulmonary Research Center, University of Cincinnati College of Medicine, Cincinnati, OH 45267
    Proc Natl Acad Sci U S A 101:13020-5. 2004
    ..We have recently shown that a genetic variant in the alpha2CAR coding region (Del322-325), which renders the receptor partially uncoupled from Gi, is a risk factor for heart ..
  6. ncbi Interaction between cardiac sympathetic drive and heart rate in heart failure: modulation by adrenergic receptor genotype
    David M Kaye
    Wynn Department of Metabolic Cardiology, Baker Heart Research Institute, Melbourne, Vic, Australia
    J Am Coll Cardiol 44:2008-15. 2004
    ....
  7. ncbi Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humans
    Alexander Neumeister
    Mood and Anxiety Disorders Program, Section on Experimental Therapeutics and Pathophysiology, NIMH, NIH, Bethesda, MD, USA
    Pharmacogenet Genomics 15:143-9. 2005
    ..In-frame deletion of the alpha2C-adrenoreceptor subtype (alpha2CDel322-325) increases the risk of congestive heart failure. Increased delivery of catecholamines to cardiovascular receptors might explain this increased risk...
  8. pmc No positive association between adrenergic receptor variants of alpha2cDel322-325, beta1Ser49, beta1Arg389 and the risk for heart failure in the Japanese population
    Shinpei Nonen
    Department of Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    Br J Clin Pharmacol 60:414-7. 2005
    ..We investigated the correlation of adrenergic receptor polymorphisms, alpha(2c)Del322-325, beta(1)Ser49Gly and beta(1)Arg389Gly, with the risk of heart failure in the Japanese population...
  9. ncbi Alpha2C-adrenoceptor polymorphism is associated with improved event-free survival in patients with dilated cardiomyopathy
    Vera Regitz-Zagrosek
    DHZB, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur Heart J 27:454-9. 2006
    ..In this study we tested whether a deletion polymorphism in the human alpha2C-adrenoceptor gene (alpha2CDel322-325) affects progression of heart failure in patients with dilated cardiomyopathy (DCM)...
  10. ncbi Effects of a alpha 2C-adrenoreceptor gene polymorphism on neural responses to facial expressions in depression
    Alexander Neumeister
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Neuropsychopharmacology 31:1750-6. 2006
    ..These results suggest that the alpha2CDel322-325-AR confers a change in brain function implicating this alpha2-AR subtype into the pathophysiology of MDD...
  11. ncbi Do allelic variants in alpha2A and alpha2C adrenergic receptors predispose to hypertension in blacks?
    Jia Ling Li
    Division of Hypertension, Department of Internal Medicine, Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, USA
    Hypertension 47:1140-6. 2006
    Sequence variations in the human alpha2 adrenergic receptor genes (ADRA2A and ADRA2C) have been implicated as a cause of hypertension in blacks...
  12. pmc Cyclic AMP acts through Rap1 and JNK signaling to increase expression of cutaneous smooth muscle alpha2C-adrenoceptors
    A H Eid
    Lebanese International University, Beirut, Lebanon
    Am J Physiol Heart Circ Physiol 295:H266-72. 2008
    ..By increasing the expression of cold-responsive alpha(2C)-ARs, this pathway may contribute to enhanced cold-induced vasoconstriction in the cutaneous circulation, including Raynaud's phenomenon...
  13. doi Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol
    Amy J Sehnert
    CardioDx, Inc, Palo Alto, California 94303, USA
    J Am Coll Cardiol 52:644-51. 2008
    ..This study investigated the role of adrenergic receptor genetics on transplant-free survival in heart failure (HF)...
  14. doi An alpha2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure
    Michael R Bristow
    University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Circ Heart Fail 3:21-8. 2010
    ..This study investigated whether alpha(2C)-AR polymorphisms affect sympatholytic effects of bucindolol in patients with heart failure...
  15. ncbi An in-frame deletion in the alpha(2C) adrenergic receptor is common in African--Americans
    J Feng
    Department of Molecular Genetics, City of Hope National Medical Center and Beckman Research Institute, 1500 East Duarte Road, Duarte, CA 91010, USA
    Mol Psychiatry 6:168-72. 2001
    ..The alpha(2c) adrenergic receptor (ADRA2C), located on chromosome 4p16...
  16. ncbi Synergistic polymorphisms of beta1 and alpha2C-adrenergic receptors and the influence on left ventricular ejection fraction response to beta-blocker therapy in heart failure
    Maximilian T Lobmeyer
    Department of Pharmacy Practice, University of Florida, Gainesville, FL 32610, USA
    Pharmacogenet Genomics 17:277-82. 2007
    ..effect of ADRB1 Arg389Gly with the insertion/deletion polymorphism in the alpha2C-adrenergic receptor gene (ADRA2C)...
  17. ncbi Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission
    L Hein
    Department of Pharmacology and Toxicology, University of Wurzburg, Germany
    Nature 402:181-4. 1999
    ....
  18. ncbi A four amino acid deletion polymorphism in the third intracellular loop of the human alpha 2C-adrenergic receptor confers impaired coupling to multiple effectors
    K M Small
    Departments of Medicine and Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Biol Chem 275:23059-64. 2000
    ....
  19. ncbi Characterization of the regulatory region of Adra2c, the gene encoding the murine alpha2C adrenoceptor subtype
    Wen Kwei Chen
    Institute of Microbiology and Immunology, National Yang Ming University, Taipei, ROC
    J Biomed Sci 11:886-901. 2004
    The 5' flanking sequence (3,227 base pairs, bp) of the mouse Adra2c subtype gene was determined and characterized. The transcription start site was mapped to nucleotide 'A' of two initiator motifs in tandem array, i.e...
  20. pmc Down-regulation of the alpha-2C adrenergic receptor: involvement of a serine/threonine motif in the third cytoplasmic loop
    Jean D Deupree
    Department of Pharmacology, University of Nebraska Medical Center, Omaha, NE 68198 6260, USA
    BMC Pharmacol 2:9. 2002
    ....
  21. pmc Attention-deficit hyperactivity disorder and the adrenergic receptors alpha 1C and alpha 2C
    C L Barr
    Department of Psychiatry, The Toronto Western Hospital, Toronto, Ontario, Canada
    Mol Psychiatry 6:334-7. 2001
    ..2, and alpha 2C (ADRA2C) located on chromosome 4p16, as genetic susceptibility factors in ADHD...
  22. pmc Molecular genetics of attention-deficit/hyperactivity disorder: an overview
    Tobias Banaschewski
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Eur Child Adolesc Psychiatry 19:237-57. 2010
    ..Genes associated with the noradrenergic (such as NET1/SLC6A2, ADRA2A, ADRA2C) and serotonergic systems (such as 5-HTT/SLC6A4, HTR1B, HTR2A, TPH2) have also received considerable interest...
  23. doi Oxo-bridged isomers of aza-trishomocubane sigma (sigma) receptor ligands: Synthesis, in vitro binding, and molecular modeling
    Samuel D Banister
    School of Chemistry, University of Sydney, NSW 2006, Australia
    Bioorg Med Chem Lett 20:145-8. 2010
    ..Molecular modeling was undertaken to rationalize these results...
  24. ncbi Assignment of two alpha 2 adrenoceptor subtype genes to murine chromosomes
    N C Chang
    Institute of Microbiology and Immunology, National Yang Ming Medical College, Taipei, Taiwan, ROC
    Neurosci Lett 167:105-8. 1994
    Subtype-specific probes to the murine homologs of the human ADRA2B and ADRA2C genes were prepared by PCR amplification and used to map these two genes to mouse chromosomes 2 and 5, respectively...
  25. ncbi G(z) signaling: emerging divergence from G(i) signaling
    M K Ho
    Department of Biochemistry and Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    Oncogene 20:1615-25. 2001
    ..In this review, we have drawn a sketch of a signaling network with G(z) as the centerpiece. The emerging picture is one that distinguishes G(z) from other members of the G(i) subfamily...
  26. ncbi Activation and deactivation kinetics of alpha 2A- and alpha 2C-adrenergic receptor-activated G protein-activated inwardly rectifying K+ channel currents
    M Bunemann
    Institut fur Pharmakologie und Toxikologie, Universitat Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
    J Biol Chem 276:47512-7. 2001
    ....
  27. ncbi Axon terminals possessing the alpha 2c-adrenergic receptor in the rat dorsal horn are predominantly excitatory
    M J Olave
    Spinal Cord Group, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
    Brain Res 965:269-73. 2003
    ..These data indicate that most dorsal horn axons possessing the alpha(2C)-AR are excitatory and add further support to the suggestion that they originate principally from spinal interneurons...
  28. ncbi Genetic variation associated with ischemic heart failure: a HuGE review and meta-analysis
    Georgios Kitsios
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Am J Epidemiol 166:619-33. 2007
    ..Seven polymorphisms (ACE I/D, AGT M235T, ADRA2C Del322-325, ADRB2 Arg16Gly, ADRB2 Gln27Glu, EDN1 Lys198Asn, VEGF G-405C) showed a significant association in ..
  29. doi Alpha- and beta-adrenergic receptor (AR) protein expression is associated with poor clinical outcome in breast cancer: an immunohistochemical study
    D G Powe
    Department of Cellular Pathology, Queen s Medical Centre, Nottingham University Hospitals Trust and School of Molecular Medical Sciences, University of Nottingham, Nottingham NG7 2UH, UK
    Breast Cancer Res Treat 130:457-63. 2011
    ..These findings suggest a possible role for targeted therapy using adrenoceptor antagonists...
  30. pmc Common α2A and α2C adrenergic receptor polymorphisms do not affect plasma membrane trafficking
    Carl M Hurt
    Department of Anesthesia CCM, Stanford University Medical School, Stanford, CA, 94305, USA
    Naunyn Schmiedebergs Arch Pharmacol 387:569-79. 2014
    ....
  31. pmc Adrenergic receptor genotype influences heart failure severity and β-blocker response in children with dilated cardiomyopathy
    Sushma Reddy
    Department of Pediatrics, Stanford University, Stanford, California
    Pediatr Res 77:363-9. 2015
    ..Adrenergic receptor (ADR) genotypes are associated with heart failure (HF) and β-blocker response in adults. We assessed the influence of ADR genotypes in children with dilated cardiomyopathy (DCM)...
  32. ncbi Genetic mapping of adrenergic receptor genes in humans
    M R Hoehe
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    J Mol Med (Berl) 73:299-306. 1995
    ..ADRA1C) mapped to the interval between NEFL and D8S283; alpha 2-C4, the gene encoding the alpha 2C AR (locus ADRA2C), mapped to the interval between D4S126 and D4S62; and the alpha 2-C10 (alpha 2A AR)/beta 1 haplotype (loci ADRA2A/..
  33. ncbi Chromosomal localization of mouse Cenpa gene
    K J Fowler
    The Murdoch Institute for Research into Birth Defects, Royal Children s Hospital, Parkville, Victoria, Australia
    Cytogenet Cell Genet 79:298-301. 1997
    ..we have localized the gene to the proximal region of mouse Chromosome 5, between the known Il6 and Yes1 loci near [Adra2C-D5H4S43-Hdh]...
  34. ncbi The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypes
    L Prezeau
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6600, USA
    J Biol Chem 274:13462-9. 1999
    ..Gen10 fusion proteins with the 3i loops of the alpha2AAR (Val217-Ala377), alpha2BAR (Lys210-Trp354), and alpha2CAR (Arg248-Val363) were used as ligands in gel overlay assays...
  35. ncbi Stimulation of alpha2-adrenergic receptor inhibits cholangiocarcinoma growth through modulation of Raf-1 and B-Raf activities
    Noriatsu Kanno
    Department of Internal Medicine, Scott and White Hospital and The Texas A and M University System, HSC COM, 76504, USA
    Hepatology 35:1329-40. 2002
    ....
  36. ncbi Novel 4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methylbenzofuran derivatives as selective alpha(2C)-adrenergic receptor antagonists
    Koji Hagihara
    Pharmaceutical Research Center, Kyowa Hakko Kogyo Co Ltd, 1188 Shimotogari, Nagaizumi cho, Sunto gun, Shizuoka 411 8731, Japan
    Bioorg Med Chem Lett 17:1616-21. 2007
    ..Among them, compound 10e has been found to show the anti-L-dopa-induced dyskinetic activity in marmosets. The structure-activity relationship of these compounds is also discussed...
  37. doi A high-density single-nucleotide polymorphism screen of 23 candidate genes in attention deficit hyperactivity disorder: suggesting multiple susceptibility genes among Chinese Han population
    L Guan
    Department of Child and Adolescent Psychiatry, Institute of Mental Health, Peking University, Beijing, China
    Mol Psychiatry 14:546-54. 2009
    ..For inattentive ADHD, MAOA, DDC and SYP showed suggestive evidence of association (empirical P<0.05). ADRA2C achieved suggestive significance (empirical P<0.05) for ADHD combined type...
  38. pmc Beta-1-adrenoceptor genetic variants and ethnicity independently affect response to beta-blockade
    Daniel Kurnik
    Department of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    Pharmacogenet Genomics 18:895-902. 2008
    ..The purpose of this study was to determine whether ethnic differences in response to beta-blockade can be explained by differing distributions of functional genetic variants in the beta1-AR...
  39. doi Sympathetic hyperactivity differentially affects skeletal muscle mass in developing heart failure: role of exercise training
    Aline V N Bacurau
    Escola de Educação Física e Esporte da Universidade de São Paulo, Departamento de Biodinâmica do Movimento do Corpo Humano, Av Professor Mello Moraes, 65, Butanta, Sao Paulo 05508 900, Brazil
    J Appl Physiol (1985) 106:1631-40. 2009
    ..ET prevented skeletal muscle myopathy in alpha(2A)/alpha(2C)ARKO mice, which highlights its importance as a therapeutic tool for HF...
  40. pmc The alpha2C-adrenoceptor deletion322-325 variant and cold-induced vasoconstriction
    Eitan A Friedman
    Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, 542 RRB, Nashville, TN 37232 6602, USA
    Clin Auton Res 19:247-54. 2009
    ..A common insertion-deletion variant in the alpha(2C)-AR gene (ADRA2C del322-325) results in an approximately 85% reduction of agonist-mediated function in vitro...
  41. doi Insertion/insertion genotype of α(2B)-adrenergic receptor gene polymorphism is associated with silent myocardial ischemia in patients with type 2 diabetes mellitus
    Qiu Jing Chen
    Department of Cardiology, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, People s Republic of China
    Clin Biochem 43:1201-4. 2010
    ..We investigated whether α(2)-adrenergic receptor (AR) polymorphisms (α(2A)-AR, α(2B)-AR and α(2C)-AR gene) affected silent myocardial ischemia (SMI) in patients with type 2 diabetes mellitus (T2DM)...
  42. doi Association between genetic polymorphisms of adrenergic receptor and diurnal intraocular pressure in Japanese normal-tension glaucoma
    Yanlin Gao
    Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Ophthalmology 117:2359-2364.e1-2. 2010
    ..To evaluate the relationship between genetic polymorphisms of the adrenergic receptor (ADR) and diurnal intraocular pressure (IOP) in Japanese normal-tension glaucoma (NTG) patients...
  43. doi Adrenergic receptor polymorphisms and prevention of ventricular arrhythmias with bucindolol in patients with chronic heart failure
    Ryan G Aleong
    University of Colorado, Division of Cardiology, Aurora, CO, USA
    Circ Arrhythm Electrophysiol 6:137-43. 2013
    ..We hypothesized that prevention of ventricular arrhythmias by the β-blocker/sympatholytic agent bucindolol is influenced by genetic variation in adrenergic receptors...
  44. doi The C-terminal half of the α2C-adrenoceptor determines the receptor's membrane expression level and drug selectivity
    Jan Anker Jahnsen
    Section of Pharmacology Center for Pharmacy, Department of Clinical Science, University of Bergen, NLB, 9th Floor, 5021, Bergen, Norway
    Naunyn Schmiedebergs Arch Pharmacol 386:1031-40. 2013
    ..To some extent, the region comprising the N-terminal half of the receptors contributed to the α2C-selectivity of spiperone, clozapine, and chlorpromazine...
  45. doi Cardiovascular pharmacogenomics: expectations and practical benefits
    R M Turner
    1 The Wolfson Centre for Personalised Medicine, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK 2 Clinical Pharmacology, The Royal Liverpool University Hospital, Liverpool, UK
    Clin Pharmacol Ther 95:281-93. 2014
    ..There is an increased risk of simvastatin-induced muscle toxicity in SLCO1B1*5 carriers, ADRB1 and ADRA2C polymorphisms are associated with differential response to bucindolol, and rare congenital arrhythmia gene ..
  46. doi Association between common genetic variants of α2A-, α2B- and α2C-adrenoceptors and the risk of silent brain infarction
    Jung O Kim
    Institute for Clinical Research, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Gyeonggi do 463 712, Republic of Korea
    Mol Med Rep 9:2459-66. 2014
    ..chain reaction was performed to genotype the ADRA2A 1780G>A, ADRA2B 301-303 insertion/deletion (I/D) and ADRA2C 322-325I/D polymorphisms...
  47. pmc In silico modeling of human α2C-adrenoreceptor interaction with filamin-2
    Marcin Pawlowski
    Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio, United States of America
    PLoS ONE 9:e103099. 2014
    ..Phylogenetic and sequence analysis showed that these interactions have evolved in warm-blooded animals. ..
  48. pmc Differential Pharmacological Regulation of Sensorimotor Gating Deficit in CB1 Knockout Mice and Associated Neurochemical and Histological Alterations
    Antonio Ortega-Alvaro
    Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    Neuropsychopharmacology 40:2639-47. 2015
    ..immunohistochemical studies were carried out to analyze dopamine transporter (DAT) and α-2C adrenergic receptor (ADRA2C) gene expressions and the distribution of parvalbumin (PV) and cholecystokinin-8 (CCK) immunoreactive (ir) ..
  49. pmc Genetic variation in alpha2-adrenoreceptors and heart rate recovery after exercise
    Utkarsh Kohli
    Department of Medicine, Vanderbilt University, Nashville, Tennessee Department of Pharmacology, Vanderbilt University, Nashville, Tennessee Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee
    Physiol Genomics 47:400-6. 2015
    ..to determine the effect of functional candidate genetic variants in autonomic pathways (6 ADRA2A, 1 ADRA2B, 4 ADRA2C, 2 ADRB1, 3 ADRB2, 2 NET, 2 CHT, and 1 GRK5) on the outcomes before and after adjustment for potential confounders...
  50. doi Immunohistochemical localization of alpha and beta adrenergic receptors in the human nasal turbinate
    Hideaki Shirasaki
    Department of Otolaryngology, Sapporo Medical University, S 1 W 16, Chuo Ku, Sapporo 060 8543 Japan Electronic address
    Auris Nasus Larynx 43:309-14. 2016
    ..AR agonists are commonly used for decongestant therapy of upper airway diseases. In order to clarify the roles of AR subtypes in the upper airways, we investigated the localization of these receptors by immunohistochemistry...
  51. pmc Altered Expression of Genes Encoding Neurotransmitter Receptors in GnRH Neurons of Proestrous Mice
    Csaba Vastagh
    Laboratory of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences Budapest, Hungary
    Front Cell Neurosci 10:230. 2016
    ..cholinergic (Chrnb2, Chrm4) and dopaminergic (Drd3, Drd4), adrenergic (Adra1b, Adra2a, Adra2c), adenosinergic (Adora2a, Adora2b), glycinergic (Glra), purinergic (P2rx7), and ..
  52. ncbi Adrenergic alpha 2C receptor genomic organization: association study in adult ADHD
    Vincenzo De Luca
    Psychiatric Neurogenetics, Department of Psychiatry, Clarke Site, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 127:65-7. 2004
    ..We examined for the presence of linkage disequilibrium between the alpha 2C adrenergic receptor (ADRA2C) microsatellite polymorphism upstream of the ADRA2C gene and adult ADHD in a sample of nuclear ..
  53. doi The α(2C)-Del322-325 adrenoceptor polymorphism and the occurrence of left ventricular hypertrophy in hypertensives
    Jacqueline Savva
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
    Blood Press 21:116-21. 2012
    ..This study aimed to investigate whether the α(2C)Del322-325 polymorphism was associated with an increased prevalence of LVH in patients with systemic hypertension...
  54. ncbi Discovery of selective alpha(2C) adrenergic receptor agonists
    Eric Jnoff
    UCB New Medicines, Chemin du Foriest, 1420 Braine L Alleud, Belgium
    ChemMedChem 7:385-90. 2012
  55. doi Association between common genetic variants of α2A-, α2B-, and α2C-adrenergic receptors and ischemic stroke
    Seung Hun Oh
    Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea
    Clin Neurol Neurosurg 115:26-31. 2013
    ..We evaluated whether common genetic variants of each three subtype of alpha2-adrenergic receptor (ADRA2A, ADRA2B, and ADRA2C) were associated with ischemic stroke.
  56. doi Plasticity of cardiovascular function in snapping turtle embryos (Chelydra serpentina): chronic hypoxia alters autonomic regulation and gene expression
    John Eme
    Department of Biological Sciences, University of North Texas, Denton, TX 76203, USA
    Am J Physiol Regul Integr Comp Physiol 304:R966-79. 2013
    ..However, expression of adrenergic receptor mRNA (Adrb1, Adra1a, Adra2c) and growth factor mRNA (Igf1, Igf2, Igf2r, Pdgfb) was lowered in H10 embryos...
  57. ncbi Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. II. Preferential coupling of the alpha 2C-adrenergic receptor to the guanine nucleotide-binding protein, Go
    I Coupry
    Cellular and Molecular Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston 02114
    J Biol Chem 267:9852-7. 1992
    ..This report indicates the utility of R-G cotransfection in mammalian cells as a "natural environment model" to characterize events occurring at the R-G and G-E interface...
  58. pmc Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype
    J W Regan
    Howard Hughes Medical Institute, Duke University Medical Center, Department of Medicine, Durham, NC 27710
    Proc Natl Acad Sci U S A 85:6301-5. 1988
    ..This ability to express the receptor in mammalian cells, free of other adrenergic receptor subtypes, should help in developing more selective alpha-adrenergic ligands...
  59. ncbi Targeted inactivation of the gene encoding the mouse alpha 2c-adrenoceptor homolog
    R E Link
    Department of Molecular and Cellular Physiology, Stanford University, California 94305, USA
    Mol Pharmacol 48:48-55. 1995
    ..As an alternative approach, we have used gene targeting in embryonic stem cells to disrupt the Adra2c gene, which encodes the alpha 2c-AR subtype in mice...
  60. ncbi Distribution of alpha 2C-adrenergic receptor-like immunoreactivity in the rat central nervous system
    D L Rosin
    Department of Pharmacology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Comp Neurol 372:135-65. 1996
    ..In general, the pattern of alpha 2C-LI throughout the neuraxis is consistent with previously published reports of the distribution of receptor mRNA detected by hybridization histochemistry...
  61. ncbi Expression of alpha 2-adrenergic receptor subtypes in the mouse brain: evaluation of spatial and temporal information imparted by 3 kb of 5' regulatory sequence for the alpha 2A AR-receptor gene in transgenic animals
    R Wang
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Neuroscience 74:199-218. 1996
    The present studies characterize the expression of the alpha 2A, alpha 2B and alpha 2C adrenergic receptor subtypes via in situ hybridization analysis of messenger RNA expression in the adult mouse brain, as well as the pattern of ..
  62. ncbi A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B
    U Klein
    Department of Division of Cardiovascular Medicine, Stanford University Medical School, Stanford, California 94305, USA
    J Biol Chem 272:19099-102. 1997
    ..These observations suggest a new role for a previously identified guanine nucleotide exchange protein in membrane biology and cell signaling...
  63. pmc Molecular cloning, sequencing and functional study of the promoter region of the human alpha2C4-adrenergic receptor gene
    S Schaak
    Institut National de la Santé et de la Recherche Médicale U 317, Institut Louis Bugnard, CHU Rangueil, 31403 Toulouse Cedex 4, France
    Biochem J 328:431-8. 1997
    ..Transfection of HepG2 and SK-N-MC cells with constructs deleted of additional 5'-flanking fragments permitted the definition of a minimal 200 bp promoter fragment containing the pseudo-TATA box and two putative SP1-binding sites...
  64. ncbi Role of arrestins in endocytosis and signaling of alpha2-adrenergic receptor subtypes
    J L DeGraff
    Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 274:11253-9. 1999
    ..However, endocytosis does not appear to be required for alpha2-adrenergic, epidermal growth factor, lysophosphatidic acid, or beta2-adrenergic receptor-mediated p42/p44 MAP kinase activation in COS-1 cells...
  65. ncbi Multivariate analysis of associations of 42 genes in ADHD, ODD and conduct disorder
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Clin Genet 58:31-40. 2000
    ....
  66. ncbi Clinical and molecular genetics of ADHD and Tourette syndrome. Two related polygenic disorders
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, California 91010, USA
    Ann N Y Acad Sci 931:50-83. 2001
    ..and the dopamine transporter; norepinephrine (NE) and epinephrine (EPI) genes--dopamine beta-hydroxylase, ADRA2A, ADRA2C, PNMT, norepinephrine transporter, MAOA, COMT; serotonin genes--TDO2, HTR1A, HTR1DA, serotonin transporter; GABA ..
  67. ncbi Norepinephrine transporter and alpha(2c) adrenoceptor allelic variants and personality factors
    Shih Jen Tsai
    Department of Psychiatry, Veterans General Hospital Taipei, Taiwan, Republic of China
    Am J Med Genet 114:649-51. 2002
    ..Our negative findings suggest that the investigated polymorphisms of the norepinephrine transporter and the alpha(2c) adrenoceptor do not play a major role in the reward-dependence personality trait as assessed by TPQ...
  68. ncbi An investigation of neurones that possess the alpha 2C-adrenergic receptor in the rat dorsal horn
    M J Olave
    Spinal Cord Group, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
    Neuroscience 115:31-40. 2002
    ..These studies indicate that noradrenaline can modulate transmission in the dorsal horn by acting through alpha(2C)-adrenergic receptors on terminals of spinal interneurones...
  69. ncbi Activity of the uptake-1 norepinephrine transporter as measured by I-123 MIBG in heart failure patients with a loss-of-function polymorphism of the presynaptic alpha2C-adrenergic receptor
    Myron C Gerson
    Division of Cardiology, University of Cincinnati, Ohio 45267 0542, USA
    J Nucl Cardiol 10:583-9. 2003
    ..We postulated that patients with the alpha(2C)Del322-325 polymorphism would have a compensatory increase in norepinephrine uptake-1 transporter activity as measured by iodine 123 metaiodobenzylguanidine (MIBG)...
  70. ncbi Distinct cAMP signaling pathways differentially regulate alpha2C-adrenoceptor expression: role in serum induction in human arteriolar smooth muscle cells
    Maqsood A Chotani
    Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA
    Am J Physiol Heart Circ Physiol 288:H69-76. 2005
    ..Such increased expression of alpha(2C)-ARs may contribute to enhanced cold-induced vasoconstriction and Raynaud's phenomenon...
  71. ncbi Expression of muscarinic and adrenergic receptors in normal human conjunctival epithelium
    Amalia Enríquez de Salamanca
    Institute of Applied Ophthalmobiology, University of Valladolid, Valladolid E 47005, Spain
    Invest Ophthalmol Vis Sci 46:504-13. 2005
    ..To study the presence of muscarinic and alpha- and beta-adrenergic receptors in a normal human conjunctival epithelial (IOBA-NHC) cell line...
  72. ncbi Identification of a naturally occurring 21 bp deletion in alpha 2c noradrenergic receptor gene and cognitive correlates to antipsychotic treatment
    Vincenzo De Luca
    Neurogenetics Section, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Street R 30, Toronto, Ont, Canada M5T 1R8
    Pharmacol Res 51:381-4. 2005
    ..improvement to antipsychotic treatment are associated with genetic variation in adrenergic alpha2C receptor (ADRA2C)...
  73. ncbi Functional adrenergic receptor polymorphisms and idiopathic orthostatic intolerance
    R Winker
    Division of Occupational Medicine, Medical University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna, Austria
    Int Arch Occup Environ Health 78:171-7. 2005
    ..The aim of this study was therefore to ascertain whether genotypes at eight polymorphic loci within five relevant adrenergic receptor genes (alpha2A, alpha2B, alpha2C, beta1 and beta2) influence the risk for IOI...
  74. ncbi Genetic variation at the human alpha2B-adrenergic receptor locus: role in blood pressure variation and yohimbine response
    Jason P Etzel
    Department of Medicine, University of California at San Diego, CA, USA
    Hypertension 45:1207-13. 2005
    ..Thus, despite considerable polymorphism in alpha2-AR genes, such variation is not a major determinant of variability in yohimbine response and by inference, in susceptibility to essential hypertension...
  75. pmc Neuron specific alpha-adrenergic receptor expression in human cerebellum: implications for emerging cerebellar roles in neurologic disease
    U B Schambra
    Department of Anatomy and Cell Biology, Quillen College of Medicine, East Tennessee State University, Box 70582, Johnson City, TN 37614 0582, USA
    Neuroscience 135:507-23. 2005
    ..subtypes, and Purkinje cells in the ansiform lobule (lobule HVII) and uvula/tonsil express alpha 1b and alpha 2c adrenergic receptor subtypes...
  76. ncbi Norepinephrine transporter knockout-induced up-regulation of brain alpha2A/C-adrenergic receptors
    R Gilsbach
    Institute of Pharmacology and Toxicology, University of Bonn, Germany
    J Neurochem 96:1111-20. 2006
    ..In an 'in vivo' test, the alpha(2)AR agonist clonidine (0.1 mg/kg) caused a significantly greater reduction of locomotor activity in NET-KO mice than in wild-type mice, showing the relevance of our findings at the functional level...
  77. ncbi Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase
    Bernd Weber
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 21, 24105 Kiel, Germany
    Cell Signal 18:1748-57. 2006
    ..Moreover, we speculate that this interaction may present one mechanism by which alpha2-adrenergic receptor agonists exert their neuroprotective effects...
  78. ncbi The alpha(2C)-adrenergic receptor mediates hyperactivity of coloboma mice, a model of attention deficit hyperactivity disorder
    Kristy J Bruno
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neurobiol Dis 23:679-88. 2006
    ..Localized in the basal ganglia, alpha(2C)-adrenergic receptors are in a prime position to impact locomotor activity and are, therefore, potential targets of pharmacotherapy for ADHD...
  79. ncbi Alpha-adrenoceptor gene variants and autonomic nervous system function in a young healthy Japanese population
    Tetsuro Matsunaga
    Laboratory of Metabolism, Graduate School of Human and Environmental Studies, Kyoto University, Sakyo ku, Kyoto, 606 8501, Japan
    J Hum Genet 52:28-37. 2007
    ....
  80. ncbi Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells
    Georgios Karkoulias
    Department of Pharmacology, School of Medicine, University of Patras, 26110 Rio Patras, Greece
    Cell Signal 19:945-57. 2007
    ....
  81. ncbi Relation of beta(2)-adrenoceptor haplotype to risk of death and heart transplantation in patients with heart failure
    Jaekyu Shin
    College of Pharmacy, Gainesville, Florida, USA
    Am J Cardiol 99:250-5. 2007
    ..receptor (ADRB1, S49G, R389G), beta(2)-adrenergic receptor (ADRB2, G16R, Q27E), alpha(2c)-adrenergic receptor (ADRA2C, insertion/deletion 322-325), angiotensinogen (AGT, M235T), angiotensin receptor type 1 (AGTR1, 1166A>C), and ..
  82. ncbi A prospective evaluation of left ventricular remodeling after inaugural anterior myocardial infarction as a function of gene polymorphisms in the renin-angiotensin-aldosterone, adrenergic, and metalloproteinase systems
    Christophe Bauters
    Centre Hospitalier Regional et Universitaire de Lille, Lille, France
    Am Heart J 153:641-8. 2007
    ..The present study was designed to prospectively assess the impact of gene polymorphisms on LVR...
  83. ncbi Estrogen increases smooth muscle expression of alpha2C-adrenoceptors and cold-induced constriction of cutaneous arteries
    A H Eid
    Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA
    Am J Physiol Heart Circ Physiol 293:H1955-61. 2007
    ..An estrogen-dependent increase in expression of cold-sensitive alpha(2C)-ARs may contribute to the increased activity of cold-induced vasoconstriction under estrogen-replete conditions...
  84. pmc Do motor control genes contribute to interindividual variability in decreased movement in patients with pain?
    Bikash K Mishra
    Clinical Pain Research Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD, USA
    Mol Pain 3:20. 2007
    ..We demonstrate an analytic method that we applied to 14 of these genes in 290 patients with acute sciatica, whose reduction in movement was estimated by items from the Roland-Morris Disability Questionnaire...
  85. ncbi An exploratory study of the association of adrenergic and serotonergic genotype and gastrointestinal motor functions
    A B M Grudell
    Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 20:213-9. 2008
    ..We conclude that genotype variation may affect gastric motor functions in different FGID phenotypes. However, these candidate genes account for only a limited amount of the variance in gastric function of patients with FGID...
  86. ncbi Association study between Tourette's syndrome and polymorphisms of noradrenergic genes (ADRA2A, ADRA2C)
    I Ching Chou
    Psychiatr Genet 17:359. 2007
  87. pmc The alpha 2C Del322-325 adrenergic receptor polymorphism is not associated with heart failure due to idiopathic dilated cardiomyopathy in black Africans
    J du Preez
    Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town
    Cardiovasc J Afr 19:15-6. 2008
    ..We hypothesised that homozygosity for the alpha 2C Del322-325 polymorphism may be a risk factor for heart failure due to idiopathic dilated cardiomyopathy (DCM) in black South Africans...
  88. doi Autoradiographic characterization of alpha(2C)-adrenoceptors in the human striatum
    Veronica Fagerholm
    Turku PET Centre, Turku, Finland
    Synapse 62:508-15. 2008
    ....
  89. pmc Candidate genes and sensory functions in health and irritable bowel syndrome
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R, Mayo Clinic, Charlton 8 110, 200 1st St SW, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 295:G219-25. 2008
    ....
  90. pmc Genetic variants in the alpha2C-adrenoceptor and G-protein contribute to ethnic differences in cardiovascular stress responses
    Daniel Kurnik
    Departments of Medicine and Pharmacology, Division of Clinical Pharmacology bDepartment of Biomedical Statistics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Pharmacogenet Genomics 18:743-50. 2008
    ..two functional variants in genes regulating sympathetic activity, a deletion in the alpha2C-adrenergic receptor (ADRA2C del322-325) and a G-protein beta3-subunit variant (GNB3 G825T), affect cardiovascular responses to physiologic ..
  91. pmc Beta1- and alpha2c-adrenoreceptor variants as predictors of clinical aspects of dilated cardiomyopathy in people of African ancestry
    A J Woodiwiss
    Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Division of Cardiology, Chris Hani Baragwanath Hospital and University of the Witwatersrand, Johannesburg
    Cardiovasc J Afr 19:188-93. 2008
    ....
  92. doi Identification and SAR around N-{2-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-[1,4]diazepan-1-yl]-ethyl}-2-phenoxy-nicotinamide, a selective alpha2C adrenergic receptor antagonist
    Snahel D Patel
    Pfizer Global Research and Development, Cambridge Laboratories, Cambridge, MA 02139, USA
    Bioorg Med Chem Lett 18:5689-93. 2008
    ..Structure-activity studies demonstrate the structural requirements for binding affinity, functional activity, and selectivity over other alpha(2)-AR subtypes...
  93. doi Association between the alpha-2C-adrenergic receptor gene and attention deficit hyperactivity disorder in a Korean sample
    Soo Churl Cho
    Department of Child and Adolescent Psychiatry, College of Medicine, Seoul National University Hospital, 28 Yongon Dong, Chongno Gu, Seoul, Republic of Korea
    Neurosci Lett 446:108-11. 2008
    ..Previous studies have suggested that the alpha-2C-adrenergic receptor gene (ADRA2C) is associated with ADHD...
  94. pmc Multiple interactions between the alpha 2C- and beta1-adrenergic receptors influence heart failure survival
    Sharon L R Kardia
    Department of Epidemiology, School of Public Health, University of Michigan, 109 Observatory St, Ann Arbor, MI 48109 2029, USA
    BMC Med Genet 9:93. 2008
    ..The purpose of this study was to investigate possible synergistic effects of polymorphisms of these two intronless genes (ADRB1 and ADRA2C, respectively) on the risk of death/transplant in heart failure patients.
  95. doi Adrenergic receptor polymorphisms in patients with stress (tako-tsubo) cardiomyopathy
    Scott W Sharkey
    Hypertrophic Cardiomyopathy Center and Cardiovascular Research Division of the Minneapolis Heart Institute Foundation, Minneapolis, MN, USA
    J Cardiol 53:53-7. 2009
    ..Sympathetic nervous system hyperactivity has been implicated in the pathophysiology of SC. Single nucleotide polymorphisms involving the adrenergic receptors (AR) might result in susceptibility to SC...
  96. pmc Pharmacogenetics of low dose clonidine in irritable bowel syndrome
    M Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research CENTER, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 21:399-410. 2009
    ..alpha2A, GNbeta3 and SLC6A4 genotypes significantly modify responses to CLO on sensory and motor GI functions in health and IBS...
  97. doi Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation
    Bernd Weber
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Cell Signal 21:1513-21. 2009
    ..These findings may present a mechanism contributing to subtype-specific alpha(2)AR trafficking and a potential pathway for the neuroprotective effects of alpha(2)AR agonists...
  98. pmc Genetic ancestry, social classification, and racial inequalities in blood pressure in Southeastern Puerto Rico
    Clarence C Gravlee
    Department of Anthropology, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 4:e6821. 2009
    ..Much debate centers on the relative importance of genetic versus sociocultural factors in explaining racial inequalities in health. However, few studies integrate genetic and sociocultural data to test competing explanations directly...
  99. doi Role of beta1-adrenoceptor in increased lipolysis in cancer cachexia
    Dong xing Cao
    Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
    Cancer Sci 101:1639-45. 2010
    ..of beta1-adrenoceptor (ADRB1), beta2-adrenoceptor (ADRB2), beta3-adrenoceptor (ADRB3), alpha2C-adrenoceptor (ADRA2C), natriuretic peptide receptor A (NPRA), insulin receptor (INSR), and HSL were determined in adipose tissues of 34 ..
  100. doi Resting sympathetic nerve activity is related to age, sex and arterial pressure but not to α2-adrenergic receptor subtype
    Azhar Maqbool
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics, Leeds, UK
    J Hypertens 28:2084-93. 2010
    ..Therefore, this study was planned to test the hypothesis that variant alleles of subtypes of α2-adrenergic receptors are associated with raised muscle sympathetic nerve activity (MSNA) in man...

Research Grants11

  1. Genetic Predictors of Incident CVD
    Sharon Kardia; Fiscal Year: 2005
    ..abstract_text> ..
  2. Genomic Predictors of Arteriosclerosis in Hypertensives
    Sharon Kardia; Fiscal Year: 2009
    ..End of Abstract) ..
  3. MECHANISMS FOR GPCR TRAFFICKING IN POLARIZED CELLS
    LEE LIMBIRD; Fiscal Year: 2004
    ..We will also explore whether these cDNAs can enrich the cell surface expression of the alpha2cAR subtype, which exists predominantly in an intracellular precursor pool in a variety of cell backgrounds...
  4. Gene x Environment Interactions in Attention Deficit Hyperactivity Disorder
    Holly Barnard; Fiscal Year: 2007
    ..The genotypes will include polymorphisms in the DRD2, DRD4, DRD5, DAT1, 5HTT, ADRA2C and DBH genes, with plans to add genotyping of polymorphisms in SNAP-25, HTR1B, ADRA2A, DRD1, DRD3 and COMT to ..
  5. ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2007
    ..abstract_text> ..
  6. ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROME
    Michael Camilleri; Fiscal Year: 2008
    ..Significance: This project will characterize pharmacogenetic mechanisms determining the response to clonidine through studies of candidate genes that control alpha2-adrenoreceptor function and norepinephrine transport in IBS. ..
  7. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..These actions may be relevant to develop new treatments for IBS. The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
  8. CONTRACTILE PROTEIN EXPRESSION IN FAILING HUMAN HEART
    Michael Bristow; Fiscal Year: 2002
    ..The data generated in this proposal should determine if altered expression of contractile proteins is a molecular explanation for systolic dysfunction in the failing human heart, and if this system can be targeted therapeutically. ..
  9. Dynamic Expression Profiling in the Intact Human Heart
    Michael Bristow; Fiscal Year: 2003
    ....
  10. GENETIC DETERMINANTS OF HIGH BP IN THREE RACIAL GROUPS
    Sharon Kardia; Fiscal Year: 2004
    ..The resulting synthesis of ideas and amassed data permits rigorous hypothesis testing not otherwise possible and will hasten understanding of the previously elusive genetic variation responsible for disease risk. ..
  11. Genetic-Adrenergic Interactions in Myocardial Failure
    Michael Bristow; Fiscal Year: 2007
    ..abstract_text> ..