ADH4

Summary

Gene Symbol: ADH4
Description: alcohol dehydrogenase 4 (class II), pi polypeptide
Alias: ADH-2, HEL-S-4, alcohol dehydrogenase 4, alcohol dehydrogenase class II pi chain, aldehyde reductase, epididymis secretory protein Li 4
Species: human

Top Publications

  1. ncbi ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Pharmacogenet Genomics 15:755-68. 2005
  2. ncbi Alcohol dehydrogenase polymorphisms influence alcohol-elimination rates in a male Jewish population
    Yehuda D Neumark
    Braun School of Public Health and Community Medicine, Hebrew University of Jerusalem Hadassah, Jerusalem, Israel
    Alcohol Clin Exp Res 28:10-4. 2004
  3. ncbi ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 31:1085-95. 2006
  4. pmc Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Hum Mol Genet 18:580-93. 2009
  5. pmc ADH single nucleotide polymorphism associations with alcohol metabolism in vivo
    Andrew J Birley
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Hum Mol Genet 18:1533-42. 2009
  6. pmc Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions
    Chen Wu
    State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Nat Genet 44:1090-7. 2012
  7. pmc Human class II (pi) alcohol dehydrogenase has a redox-specific function in norepinephrine metabolism
    G Mårdh
    Proc Natl Acad Sci U S A 83:8908-12. 1986
  8. ncbi Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patients
    Camila Guindalini
    Human Genome Research Center, Department of Biology, Institute of Biosciences, University of Sao Paulo, Rua do Matao, Travessa 13, Number 106, Cidade Universitária CEP 05508 090, Sao Paulo SP, Brazil
    Am J Psychiatry 162:1005-7. 2005
  9. pmc Personality traits of agreeableness and extraversion are associated with ADH4 variation
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 61:599-608. 2007
  10. pmc Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample
    Po Hsiu Kuo
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Hospital 138, National Cheng Kung University, Sheng Li Road, Tainan 704, Taiwan
    Alcohol Clin Exp Res 32:785-95. 2008

Detail Information

Publications249 found, 100 shown here

  1. ncbi ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Pharmacogenet Genomics 15:755-68. 2005
    We found strong associations between ADH4 gene variation and alcohol and drug dependence by the Hardy-Weinberg Disequilibrium (HWD) test and case-control association analysis in an initial study...
  2. ncbi Alcohol dehydrogenase polymorphisms influence alcohol-elimination rates in a male Jewish population
    Yehuda D Neumark
    Braun School of Public Health and Community Medicine, Hebrew University of Jerusalem Hadassah, Jerusalem, Israel
    Alcohol Clin Exp Res 28:10-4. 2004
    ..The mechanism by which this allelic effect is mediated is not yet clearly understood. This study examined the effect of ADH2*2 on alcohol-elimination rates (AER) under experimental conditions...
  3. ncbi ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 31:1085-95. 2006
    ..The ADH4 gene, an important member of this family, is a functional and positional candidate for alcohol dependence...
  4. pmc Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Hum Mol Genet 18:580-93. 2009
    ..001) between alcohol consumption phenotypes and rs1693482 (ADH1C), rs1230165 (ADH5) and rs3762894 (ADH4)...
  5. pmc ADH single nucleotide polymorphism associations with alcohol metabolism in vivo
    Andrew J Birley
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Hum Mol Genet 18:1533-42. 2009
    ..SNPs were associated with the early stages of alcohol metabolism, with additional effects in the ADH1A, ADH1B and ADH4 regions...
  6. pmc Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions
    Chen Wu
    State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Nat Genet 44:1090-7. 2012
    ..Our results underscore the direct genetic contribution to ESCC risk, as well as the genetic contribution to ESCC through interaction with alcohol consumption...
  7. pmc Human class II (pi) alcohol dehydrogenase has a redox-specific function in norepinephrine metabolism
    G Mårdh
    Proc Natl Acad Sci U S A 83:8908-12. 1986
    ..These features and the presence of pi ADH in human liver imply a physiological role for pi ADH in the degradation of circulating epinephrine and norepinephrine...
  8. ncbi Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patients
    Camila Guindalini
    Human Genome Research Center, Department of Biology, Institute of Biosciences, University of Sao Paulo, Rua do Matao, Travessa 13, Number 106, Cidade Universitária CEP 05508 090, Sao Paulo SP, Brazil
    Am J Psychiatry 162:1005-7. 2005
    The authors evaluated the association of three functional promoter polymorphisms of the ADH4 gene with alcohol dependence.
  9. pmc Personality traits of agreeableness and extraversion are associated with ADH4 variation
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 61:599-608. 2007
    ..Strong associations between ADH4 variation and SD have been reported...
  10. pmc Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample
    Po Hsiu Kuo
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Hospital 138, National Cheng Kung University, Sheng Li Road, Tainan 704, Taiwan
    Alcohol Clin Exp Res 32:785-95. 2008
    ..The present study examined evidence for the association of alcohol metabolism genes with AD in the Irish Affected Sib Pair Study of alcohol dependence...
  11. ncbi Cutaneous metabolism of glycol ethers
    David J Lockley
    Skin Toxicology Group, Department of Environmental and Occupational Medicine, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
    Arch Toxicol 79:160-8. 2005
    ..However, ADH1, ADH3 and ADH4 predominate in rat skin, demonstrate different sensitivities to pyrazole, and are responsible for metabolising ..
  12. pmc The intra- and extracellular proteome of Aspergillus niger growing on defined medium with xylose or maltose as carbon substrate
    Xin Lu
    Helmholtz Center for Infection Research, Inhoffenstr, Braunschweig, Germany
    Microb Cell Fact 9:23. 2010
    ..13 growing on defined medium with xylose or maltose as carbon substrate was carried out using 2-D gel electrophoresis/Maldi-ToF and nano-HPLC MS/MS...
  13. pmc Regulation of aflatoxin B1-metabolizing aldehyde reductase and glutathione S-transferase by chemoprotectors
    L I McLellan
    Department of Clinical Biochemistry, University of Edinburgh, Royal Infirmary, U K
    Biochem J 300:117-24. 1994
    ..In addition, the effect of these drugs on the hepatic levels of an aldehyde reductase (AFB1-AR) that metabolizes the cytotoxic dialdehydic form of AFB1 has been studied as this enzyme also ..
  14. ncbi Molecular and metabolic retinoid pathways in the human ocular surface
    Hachemi Nezzar
    Universite d Auvergne, JE 2447, ARDEMO, France
    Mol Vis 13:1641-50. 2007
    ..The second objective was to demonstrate the presence of different enzymes transforming vitamin A to retinoic acid and the functionality of this metabolic pathway in the corneal epithelium...
  15. ncbi Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members
    Teruhiko Iino
    Department of General Studies, Nihon University, Sakurajosui 3 25 40, Setagaya Ku, Tokyo 156 8550, Japan
    Arch Biochem Biophys 416:180-7. 2003
    ..by 3 alpha-hydroxysteroid dehydrogenase type 2, whereas 1(')-OXPH(4) was produced by aldose reductase, aldehyde reductase, and 20 alpha-hydroxysteroid dehydrogenase, and both 1(')-OXPH(4) and 2(')-OXPH(4) were detected as the ..
  16. ncbi Vitamin C. Biosynthesis, recycling and degradation in mammals
    Carole L Linster
    Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, Brussels, Belgium
    FEBS J 274:1-22. 2007
    ..Glucuronate is converted to l-gulonate by aldehyde reductase, an enzyme of the aldo-keto reductase superfamily...
  17. ncbi The role of liver alcohol dehydrogenase isoenzymes in the oxidation of glycolethers in male and female rats
    L Aasmoe
    Department of Clinical Pharmacology, University Hospital, University of Tromsø, Norway
    Toxicol Appl Pharmacol 150:86-90. 1998
    ..However, it was the same ADH isoenzyme (ADH-3) that oxidized the different glycolethers tested in both male and female rat livers, and the substrate specificity was 2-BE > 2-EE > 2-ME...
  18. ncbi Tracing the history of an enzyme polymorphism: the case of alcohol dehydrogenase-2 (Adh-2) of the olive fruit fly Bactrocera oleae
    George N Goulielmos
    Department of Genetics, Agricultural University of Athens, Athens, Greece
    Mol Biol Evol 20:293-306. 2003
    ..The estimated age of the polymorphism is compatible with this hypothesis, but firmer support could be difficult to obtain...
  19. ncbi Rat liver alcohol dehydrogenase of class III. Primary structure, functional consequences and relationships to other alcohol dehydrogenases
    P Julia
    Department of Chemistry I, Karolinska Institutet, Stockholm, Sweden
    Eur J Biochem 172:73-83. 1988
    ..Finally the class III structure supports evolutionary relationships suggesting that the three classes constitute clearly separate enzymes within the group of mammalian zinc-containing alcohol dehydrogenases...
  20. ncbi Impaired retinol utilization in Adh4 alcohol dehydrogenase mutant mice
    L Deltour
    Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
    Dev Genet 25:1-10. 1999
    b>Adh4, a member of the mouse alcohol dehydrogenase (ADH) gene family, encodes an enzyme that functions in vitro as a retinol dehydrogenase in the conversion of retinol to retinoic acid, an important developmental signaling molecule...
  21. pmc Distinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant mice
    Andrei Molotkov
    Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 277:13804-11. 2002
    The ability of class I alcohol dehydrogenase (ADH1) and class IV alcohol dehydrogenase (ADH4) to metabolize retinol to retinoic acid is supported by genetic studies in mice carrying Adh1 or Adh4 gene disruptions...
  22. ncbi Aldose reductase: an aldehyde scavenging enzyme in the intraneuronal metabolism of norepinephrine in human sympathetic ganglia
    Minoru Kawamura
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Auton Neurosci 96:131-9. 2002
    ..Although similar formation of DHPG was observed with human liver aldehyde reductase, the production of DHPG was more effective with aldose reductase than aldehyde reductase...
  23. ncbi Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter
    Elizabeth M Ellis
    Department of Bioscience and Pharmaceutical Sciences, University of Strathclyde, Glasgow G1 1XW, UK
    Carcinogenesis 24:727-37. 2003
    Rat aflatoxin B(1) aldehyde reductase (called AFAR1 or AKR7A1) is a member of the aldo-keto reductase 7 family, which metabolizes the environmental carcinogen aflatoxin B(1)...
  24. doi Quantification of urinary aflatoxin B1 dialdehyde metabolites formed by aflatoxin aldehyde reductase using isotope dilution tandem mass spectrometry
    Denise N Johnson
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Chem Res Toxicol 21:752-60. 2008
    ..This urinary detection of the alcohol products directly contributes to the goal of mass balancing the fate of the bioreactive 8,9-epoxides of AFB 1 in vivo...
  25. pmc Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins
    Vincent P Kelly
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    Biochem J 366:847-61. 2002
    The aldo-keto reductase (AKR) 7 family is composed of the dimeric aflatoxin B(1) aldehyde reductase (AFAR) isoenzymes. In the rat, two AFAR subunits exist, designated rAFAR1 and rAFAR2...
  26. ncbi Aldose reductase in human retinal pigment epithelial cells
    S Sato
    Laboratory of Ocular Therapeutics, National Eye Institute, National Institutes of Health, Bethesda, MD 20892
    Exp Eye Res 57:235-41. 1993
    ..In addition to aldose reductase, chromatofocusing demonstrated the presence of aldehyde reductase, another NADPH-dependent reductase...
  27. ncbi Cloning of the human aflatoxin B1-aldehyde reductase gene at 1p35-1p36.1 in a region frequently altered in human tumor cells
    C Praml
    Division of Cytogenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Cancer Res 58:5014-8. 1998
    ..a gene encoding a protein of 330 amino acids that is 78% identical with the Rattus norvegicus aflatoxin B1 aldehyde reductase (Afar) and, therefore, likely represents its human homologue...
  28. ncbi Enzymes in pancreatic islets that use NADP(H) as a cofactor including evidence for a plasma membrane aldehyde reductase
    M Laclau
    University of Wisconsin Childrens Diabetes Center, Madison, USA
    Mol Cell Biochem 225:151-60. 2001
    ..Significant activities of glutathione reductase, aldose reductase (EC.1.1.1.21) and aldehyde reductase (EC.1.1.1.2) were present in islets...
  29. pmc Enzymes of glycerol and glyceraldehyde metabolism in mouse liver: effects of caloric restriction and age on activities
    Kevork Hagopian
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Biosci Rep 28:107-15. 2008
    ..Aldehyde dehydrogenase and aldehyde reductase activities in both young and old CR mice were unchanged by caloric restriction...
  30. ncbi Purification and characterization of human testis aldose and aldehyde reductase
    T Tanimoto
    Division of Biological Chemistry, National Institute of Hygienic Sciences, Tokyo, Japan
    Int J Biochem 23:421-8. 1991
    1. Aldose reductase and aldehyde reductase were purified to homogeneity from human testis. 2...
  31. ncbi Alcohol dehydrogenases in Xenopus development: conserved expression of ADH1 and ADH4 in epithelial retinoid target tissues
    I Hoffmann
    Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
    Dev Dyn 213:261-70. 1998
    Mammalian alcohol dehydrogenases ADH1 (class I ADH) and ADH4 (class IV ADH) function as retinol dehydrogenases contributing to the synthesis of retinoic acid, the active form of vitamin A involved in growth and development...
  32. ncbi Characterization of the serotoninergic system in the C57BL/6 mouse skin
    Andrzej Slominski
    Department of Pathology, University of Tennessee Health Science Center, Memphis, TN, USA
    Eur J Biochem 270:3335-44. 2003
    ..acid, probably through stepwise transformation catalyzed by monoamine oxidase, aldehyde dehydrogenase and aldehyde reductase. Activity of the melatonin-forming enzyme hydroxyindole-O-methyltransferase was notably below detectable ..
  33. ncbi Isolation of a set of genes expressed in the choroid plexus of the mouse using suppression subtractive hybridization
    N Matsumoto
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Neuroscience 117:405-15. 2003
    ..gelsolin, phospholipid transfer protein, ATP-binding cassette transporter A8 (ABCA8), androgen-inducible aldehyde reductase, and Na(+)/sulfate cotransporter SUT-1...
  34. pmc A novel aldehyde reductase with activity towards a metabolite of aflatoxin B1 is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidant
    D J Judah
    MRC Toxicology Unit, Carshalton, Surrey, U K
    Biochem J 292:13-8. 1993
    In contrast with fractions from control animals, an aldehyde reductase, which catalyses the reduction of aflatoxin B1-dihydrodiol, in the dialdehyde form at physiological pH values, to aflatoxin B1-dialcohol, is expressed in cytosolic ..
  35. pmc Structural similarity of bovine lung prostaglandin F synthase to lens epsilon-crystallin of the European common frog
    K Watanabe
    Hayaishi Bioinformation Transfer Project, Kyoto Laboratory, Research Development Corporation of Japan
    Proc Natl Acad Sci U S A 85:11-5. 1988
    ..that bovine lung PGF synthase shows 62% identical plus conservative substitutions compared with human liver aldehyde reductase [Wermuth, B., Omar, A., Forster, A., Francesco, C., Wolf, M., Wartburg, J.P., Bullock, B. & Gabbay, K.H...
  36. ncbi Cloning and expression of two novel aldo-keto reductases from Digitalis purpurea leaves
    Isabel Gavidia
    Center of Plant Molecular Biology ZMBP, University of Tubingen, Germany
    Eur J Biochem 269:2842-50. 2002
    ..proteins present high identities (68-80%) with four Arabidopsis clones and a 67% identity with the aldose/aldehyde reductase from Medicago sativa...
  37. doi Escherichia coli YqhD exhibits aldehyde reductase activity and protects from the harmful effect of lipid peroxidation-derived aldehydes
    Jose Manuel Perez
    Laboratorio de Microbiologia Molecular, Departamento de Biologia, Facultad de Quimica y Biologia, Universidad de Santiago de Chile, Santiago 9170019, Chile
    J Biol Chem 283:7346-53. 2008
    ..We speculate that in Escherichia coli YqhD is part of a glutathione-independent, NADPH-dependent response mechanism to lipid peroxidation...
  38. ncbi Molecular cloning and expression of rat liver 3 alpha-hydroxysteroid dehydrogenase
    K C Cheng
    Department of Pediatrics Cornell University Medical College, New York, New York 10021
    Mol Endocrinol 5:823-8. 1991
    ..other enzymes, including bovine prostaglandin F synthase, human chlordecone reductase, human aldose reductase, human aldehyde reductase, and frog lens epsilon-crystalline, suggesting that these proteins belong to the same gene family.
  39. ncbi Metyrapone reductase purified partially from liver microsomes of male rats: the enzyme differs from acetohexamide reductase
    Y Imamura
    Faculty of Pharmaceutical Sciences, Kumamoto University, Japan
    Res Commun Mol Pathol Pharmacol 96:219-26. 1997
    ..The substrate specificities were in fair agreement with those of carbonyl reductase. However, the partially purified enzyme was strongly inhibited by inhibitors of aldehyde reductase, such as barbital, phenobarbital and sodium valproate.
  40. ncbi Carbonyl reductases and pluripotent hydroxysteroid dehydrogenases of the short-chain dehydrogenase/reductase superfamily
    Frank Hoffmann
    Institute of Toxicology and Pharmacology for Natural Scientists, University Medical School Schleswig Holstein, Campus Kiel, Brunswiker Strasse, Kiel, 10, 24105, Germany
    Drug Metab Rev 39:87-144. 2007
    ..Whereas aldehyde reductase and aldose reductase are AKRs, several forms of carbonyl reductase belong to the SDRs...
  41. doi Proteomic analysis of pancreatic ductal adenocarcinoma compared with normal adjacent pancreatic tissue and pancreatic benign cystadenoma
    Yazhou Cui
    Key Laboratory of Ministry of Health for Biotech Drug, Shandong Medicinal Biotechnology Center, Shandong Academy of Medical Sciences, Jinan, PR China
    Pancreatology 9:89-98. 2009
    ..Dual expression of potential biomarkers in both benign and malignant pancreatic tumors was a major obstacle in the development of diagnostic biomarkers of early pancreatic cancer...
  42. pmc Polyol formation in cell lines of rat retinal capillary pericytes and endothelial cells (TR-rPCT and TR-iBRB)
    Peter F Kador
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198 6025, USA
    J Ocul Pharmacol Ther 25:299-308. 2009
    ....
  43. ncbi Stable preparation of aldose reductase isoenzymes from human placenta
    Y Fujii
    Department of Chemistry, Fukui Medical School, Japan
    Protein Expr Purif 2:420-5. 1991
    ..Kinetic studies indicate that GAR1 belongs to an aldose reductase (a low-Km form) and GAR2 to an aldehyde reductase (a high-Km form)...
  44. ncbi Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase
    C J Winters
    Department of Medicine, Medical College of Virginia, Richmond 23298
    Biochemistry 29:1080-7. 1990
    ..The deduced protein sequence of CDR showed 65% similarity to the primary structure of human liver aldehyde reductase and 66% similarity to the inferred protein sequence of rat lens aldose reductase...
  45. ncbi Characterization of the functional gene encoding mouse class III alcohol dehydrogenase (glutathione-dependent formaldehyde dehydrogenase) and an unexpressed processed pseudogene with an intact open reading frame
    M H Foglio
    La Jolla Cancer Foundation Research Foundation, CA 92037, USA
    Eur J Biochem 237:496-504. 1996
    ..Reporter gene expression following transfection into mouse F9 embryonal carcinoma cells indicated that only Adh-2 possesses promoter activity...
  46. ncbi Mitochondrial aldehyde reductase: identification and characterization in rat liver and kidney cortex
    E A Udovikova
    Nencki Institute of Experimental Biology, Warsaw, Poland
    Int J Biochem Cell Biol 30:597-608. 1998
    b>Aldehyde reductase (EC 1.1.1.2) has been regarded so far as an exclusively cytosolic enzyme...
  47. ncbi Metabolism of the 2-oxoaldehyde methylglyoxal by aldose reductase and by glyoxalase-I: roles for glutathione in both enzymes and implications for diabetic complications
    D L Vander Jagt
    Department of Biochemistry and Molecular Biology, School of Medicine, University of New Mexico, 87131, Albuquerque, NM, USA
    Chem Biol Interact 130:549-62. 2001
    ..Thus, glutathione converts aldose reductase from an aldehyde reductase to a ketone reductase with methylglyoxal as substrate...
  48. ncbi Association of polymorphism in the alcohol dehydrogenase 2 gene with alcohol-induced testicular atrophy
    M Yamauchi
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Alcohol Clin Exp Res 25:16S-8S. 2001
    ..Alcohol abuse can induce testicular atrophy, but it only occurs in some alcoholics. Alcohol dehydrogenase (ADH) is located principally on the Leydig cells...
  49. ncbi Discovery of new inhibitors of aldose reductase from molecular docking and database screening
    Giulio Rastelli
    Dipartimento di Scienze Farmaceutiche, Universita di Modena e Reggio Emilia, Via Campi 183, 41100, Modena, Italy
    Bioorg Med Chem 10:1437-50. 2002
    ..For these active compounds, selectivity with respect to the closely-related aldehyde reductase was determined by measuring the corresponding inhibitory activities...
  50. ncbi A549 subclones demonstrate heterogeneity in toxicological sensitivity and antioxidant profile
    Nobuo Watanabe
    Department of Environmental Health Sciences, School of Public Health and Center for Free Radical Biology, University of Alabama, Birmingham 35294 0022, USA
    Am J Physiol Lung Cell Mol Physiol 283:L726-36. 2002
    ..glutathione and glutathione reductase activity but markedly lower catalase, glutathione peroxidase, and aldehyde reductase activities than G4S cells...
  51. ncbi Biosynthesis of podophyllotoxin in Linum album cell cultures
    Veronique Seidel
    Natural Products Research, Faculty of Applied Sciences, De Montfort University, The Gateway, Leicester LEI 9BH, UK
    Planta 215:1031-9. 2002
    ..Electronic supplementary material to this paper can be obtained by using the Springer LINK server located at http://dx.doi.org/wo.1007/s00425-002-0834-1...
  52. ncbi Carbonyl stress and detoxification ability in the male genital tract and testis of rats
    Yoshihito Iuchi
    Department of Biochemistry, Yamagata University School of Medicine, 2 2 2 Iidanishi, 990 9585 Yamagata, Japan
    Histochem Cell Biol 121:123-30. 2004
    ..in the male reproductive system, we investigated the differential expression and tissue localization of aldehyde reductase (ALR) and protein adducts produced by reaction with lipid peroxidation products...
  53. ncbi The effects of pregnancy on ethanol clearance
    Thomas M Badger
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Life Sci 77:2111-26. 2005
    ..The greater ethanol clearance results in lower tissue ethanol concentrations achieved during pregnancy for a given dose, and this may have clinical significance as a mechanism to protect the growing fetus from ethanol toxicity...
  54. pmc Identification of proteins differentially expressed in the conventional renal cell carcinoma by proteomic analysis
    Jeong Seok Hwa
    Department of Urologym, College of Medicine Gyeongsang National University, Jinju, Korea
    J Korean Med Sci 20:450-5. 2005
    ..The expression of the following proteins was repressed (p<0.05); aminoacylase-1, enoyl-CoA hydratase, aldehyde reductase, tropomyosin alpha-4 chain, agmatinase and ketohexokinase...
  55. ncbi Allozyme variability and phylogenetic relationships in honey bee (Hymenoptera: Apidae: Apis mellifera) populations from Greece and Cyprus
    M Bouga
    Department of Biology, Division of Genetics, Cell Biology and Development, University of Patras, Rio, 265 00, Patras, Greece
    Biochem Genet 43:471-83. 2005
    ..Our allozymic data support A. m. cypria as a distinct subspecies, but there was no allozymic support for the distinction of the other subspecies existing in Greece...
  56. ncbi [Age-related characteristics of changes in aldehyde reductase activity in the skeletal muscle of rats during immobilization stress]
    E V Fomina
    Biomed Khim 52:378-83. 2006
    A study of peculiarities of aldehyde reductase (AR) activity changes in the skeletal muscle from 1.5-, 2-, 6-, 12-, 24-months old rats during immobilization stress has been carried out...
  57. ncbi Selectivity determinants of the aldose and aldehyde reductase inhibitor-binding sites
    O El-Kabbani
    Department of Medicinal Chemistry, Victorian College of Pharmacy, Monash University, Parkville Campus, 381 Royal Parade, Parkville, Victoria, 3052 Australia
    Cell Mol Life Sci 64:1970-8. 2007
    Aldose reductase and aldehyde reductase belong to the aldo-keto reductase superfamily of enzymes whose members are responsible for a wide variety of biological functions...
  58. ncbi Folate salvage in plants: pterin aldehyde reduction is mediated by multiple non-specific aldehyde reductases
    Alexandre Noiriel
    Horticultural Sciences Department, University of Florida, Gainesville, FL 32611, USA
    Plant J 51:378-89. 2007
    ..An Arabidopsis gene (At1g10310) encoding a pterin aldehyde reductase was identified by searching the short-chain dehydrogenase/reductase family for proteins predicted to be ..
  59. doi The role of aryl hydrocarbon receptor in regulation of enzymes involved in metabolic activation of polycyclic aromatic hydrocarbons in a model of rat liver progenitor cells
    Jan Vondracek
    Department of Cytokinetics, Institute of Biophysics ASCR, Brno, Czech Republic
    Chem Biol Interact 180:226-37. 2009
    ..In contrast, the aldehyde reductase AKR1A1 was not induced by either treatment...
  60. doi Induction of alcohol-metabolizing enzymes and heat shock protein expression by ethanol and modulation by fenugreek seed polyphenols in Chang liver cells
    S Kaviarasan
    Department of Biochemistry, Annamalai University, Annamalai, Tamil Nadu, India kavi
    Toxicol Mech Methods 19:116-22. 2009
    ..FPEt might exert cytoprotective action on ethanol-induced liver cell damage, possibly by enhancing cellular redox status...
  61. doi Influence of the isolation procedure on coriander leaf volatiles with some correlation to the enzymatic activity
    Cung Thi To Quynh
    Department of Food and Nutritional Sciences, Graduate School of Humanities and Sciences, Ochanomizu University, Tokyo 112 8610, Japan
    J Agric Food Chem 58:1093-9. 2010
    ..By using aliphatic aldehyde as a substrate and NADPH as a coenzyme, strong activity of an aliphatic aldehyde reductase was found for the first time in this herb in the relatively wide pH range of 5.0-9...
  62. pmc Identification of a FOXA-dependent enhancer of human alcohol dehydrogenase 4 (ADH4)
    Sirisha Pochareddy
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS4063, Indianapolis, IN 46202 5122, USA
    Gene 460:1-7. 2010
    Human alcohol dehydrogenase 4 (ADH4) is one of the key enzymes involved in the metabolism of alcohol. ADH4 is highly expressed in the liver, and previous studies have revealed several cis-acting elements in the proximal promoter region...
  63. ncbi A new cotton SDR family gene encodes a polypeptide possessing aldehyde reductase and 3-ketoacyl-CoA reductase activities
    Yu Pang
    National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, China
    Biochemistry (Mosc) 75:320-6. 2010
    ..Our results suggest that GhKCR3 is probably a novel KCR contributing to very long-chain fatty acid biosynthesis in plants...
  64. doi Characterization of a novel NADPH-dependent oxidoreductase from Gluconobacter oxydans
    Minmin Chen
    State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai, 200237, China
    Mol Biotechnol 46:176-81. 2010
    ..Based on these results, GOX0644 was defined as a novel NADPH-dependent aldehyde reductase. Kinetic parameters of the protein and the dependence of its activity on temperature and pH were also ..
  65. doi Adh1 and Adh1/4 knockout mice as possible rodent models for presymptomatic Parkinson's disease
    Anna Anvret
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Behav Brain Res 227:252-7. 2012
    ..Genetic variants in ADH1C and ADH4 have been found to associate with PD and lack of Adh4 gene activity in a mouse model has recently been reported to ..
  66. doi Identification of ADH4 as a novel and potential prognostic marker in hepatocellular carcinoma
    Rong Rong Wei
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, 651 Dongfeng East Road, Room 617, Guangzhou, 510060, Guangdong, China
    Med Oncol 29:2737-43. 2012
    b>Alcohol dehydrogenase 4 (ADH4) is an important member of ADH family that metabolize a wide variety of substrates including ethanol and retinol. Studies demonstrated that ADH4 was involved in cancer...
  67. doi In vivo role of aldehyde reductase
    Motoko Takahashi
    Department of Biochemistry, Sapporo Medical University School of Medicine, Sapporo, Japan
    Biochim Biophys Acta 1820:1787-96. 2012
    b>Aldehyde reductase (AKR1A; EC 1.1.1.2) catalyzes the reduction of various types of aldehydes. To ascertain the physiological role of AKR1A, we examined AKR1A knockout mice.
  68. ncbi Detoxification potential and expression analysis of eutypine reducing aldehyde reductase (VrALR) during progressive drought and recovery in Vigna radiata (L.) Wilczek roots
    Debashree Sengupta
    Photosynthesis and Plant Stress Biology Laboratory, Department of Plant Sciences, School of Life Sciences, University of Hyderabad, Hyderabad 500046, India
    Planta 236:1339-49. 2012
    ..Here, we have cloned the eutypine reducing aldehyde reductase gene (VrALR) from Vigna radiata (L.) Wilczek roots...
  69. pmc Characterization of erythrose reductases from filamentous fungi
    Birgit Jovanovic
    Department for Biotechnology and Microbiology, Institute of Chemical Engineering, Vienna University of Technology, Gumpendorfer Str, 1a, Wien A 1060, Austria
    AMB Express 3:43. 2013
    ..The proteins found in T. reesei and A. niger had earlier been characterized as glycerol dehydrogenase and aldehyde reductase, respectively...
  70. doi Production of acetol from glycerol using engineered Escherichia coli
    Hongliang Zhu
    Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
    Bioresour Technol 149:238-43. 2013
    ..In addition, the aldehyde reductase YqhD was overexpressed which led to an increase of acetol production by 11.4-fold...
  71. doi Inhibition of human alcohol and aldehyde dehydrogenases by acetaminophen: Assessment of the effects on first-pass metabolism of ethanol
    Yung Pin Lee
    Department of Biological Sciences, National Sun Yat Sen University, Kaohsiung, Taiwan
    Alcohol 47:559-65. 2013
    ..inhibition of ethanol oxidation with recombinant human ADH1A, ADH1B1, ADH1B2, ADH1B3, ADH1C1, ADH1C2, ADH2, and ADH4, and inhibition of acetaldehyde oxidation with recombinant human ALDH1A1 and ALDH2...
  72. doi Biosynthesis of odd-chain fatty alcohols in Escherichia coli
    Ying Xiu Cao
    Key Laboratory of Systems Bioengineering Ministry of Education, Tianjin University, Tianjin 300072, PR China SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering Tianjin, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, PR China Electronic address
    Metab Eng 29:113-23. 2015
    ..Through combining αDOX with fatty acyl-acyl carrier protein (-ACP) thioesterase (TE) and aldehyde reductase (AHR), the medium odd-chain fatty alcohols profile (C11, C13, C15) was firstly established in E. coli...
  73. doi Heterologous biosynthesis and manipulation of alkanes in Escherichia coli
    Ying Xiu Cao
    Key Laboratory of Systems Bioengineering Ministry of Education, Tianjin University, Tianjin 300072, PR China SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering Tianjin, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, PR China Electronic address
    Metab Eng 38:19-28. 2016
    ..by the facilitation of moderate fatty alcohol biosynthesis, which was validated by deletion of endogenous aldehyde reductase (AHR), overexpression of fatty alcohol oxidase (FAO) and consequent transcriptional assay of aar, ado and ..
  74. pmc Genomic characterization of liver metastases from colorectal cancer patients
    Jose Maria Sayagues
    Cytometry service NUCLEUS, Department of Medicine, Cancer Research Center, IBMCC CSIC USAL and IBSAL, University of Salamanca, Salamanca, Spain
    Oncotarget 7:72908-72922. 2016
    ..Newly deregulated metastatic transcripts included overexpression of APOA1, HRG, UGT2B4, RBP4 and ADH4 mRNAS and the miR-3180-3p, miR-3197, miR-3178, miR-4793 and miR-4440 miRNAs, together with decreased expression of ..
  75. doi Enhanced yield of ethylene glycol production from d-xylose by pathway optimization in Escherichia coli
    Rhudith B Cabulong
    Department of Energy Science and Technology DEST, Energy and Environment Fusion Technology Center E 2 FTC, Myongji University, Myongji Ro 116, Cheoin gu, Yongin, Gyeonggi Do, 170 58, South Korea
    Enzyme Microb Technol 97:11-20. 2017
    ..Second, EG yield was further improved by expressing the YjgB, which was identified as the most suitable aldehyde reductase endogenous to E. coli...
  76. ncbi Aldose reductase from human psoas muscle. Affinity labeling of an active site lysine by pyridoxal 5'-phosphate and pyridoxal 5'-diphospho-5'-adenosine
    N A Morjana
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada
    J Biol Chem 264:2912-9. 1989
    ..the essential lysine was found to be highly homologous with a segment of the sequence of both human liver aldehyde reductase and rat lens aldose reductase...
  77. ncbi Molecular cloning and expression of an abundant rabbit ovarian protein with 20 alpha-hydroxysteroid dehydrogenase activity
    W R Lacy
    Department of Cell Biology, Baylor College of Medicine Houston, Texas 77030
    Mol Endocrinol 7:58-66. 1993
    ..to human chlordecone reductase, bovine lung prostaglandin F synthase, human aldose reductase, human aldehyde reductase, and frog lens rho-crystallin, placing rabbit ovarian 20 alpha HSD in the aldo-keto reductase family of ..
  78. ncbi Identity of a major 3-deoxyglucosone-reducing enzyme with aldehyde reductase in rat liver established by amino acid sequencing and cDNA expression
    M Takahashi
    Department of Biochemistry, Osaka University Medical School, Japan
    Gene 127:249-53. 1993
    ..obtained from the rat 3-DG-reducing enzyme by lysylendopeptidase digestion with the aa sequence of human aldehyde reductase (ALR) [Bohren et al., J. Biol. Chem...
  79. ncbi Purification and characterization of a novel cytosolic NADP(H)-dependent retinol oxidoreductase from rabbit liver
    D Y Huang
    Department of Biochemistry, School of Medicine, Kagawa Medical University, Japan
    Biochim Biophys Acta 1338:47-59. 1997
    ..This enzyme exhibits relatively broad aldehyde reductase activity and some ketone reductase activity, the activity for aromatic substitutive aldehydes being ..
  80. pmc Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase
    L S Ireland
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Biochem J 332:21-34. 1998
    ..the enzyme responsible for the reduction of 2-CBA in humans is identified as a homologue of rat aflatoxin B1-aldehyde reductase (rAFAR)...
  81. ncbi Regulation of rat glutathione S-transferase A5 by cancer chemopreventive agents: mechanisms of inducible resistance to aflatoxin B1
    J D Hayes
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    Chem Biol Interact 111:51-67. 1998
    ..In addition to GSTA5, we have identified a novel aflatoxin-aldehyde reductase (AFAR) that is similarly induced by ethoxyquin...
  82. ncbi ADH4-lacZ transgenic mouse reveals alcohol dehydrogenase localization in embryonic midbrain/hindbrain, otic vesicles, and mesencephalic, trigeminal, facial, and olfactory neural crest
    R J Haselbeck
    Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
    Alcohol Clin Exp Res 22:1607-13. 1998
    ..Herein, we have used transgenic mice to examine the mouse gene encoding class IV ADH (ADH4), an enzyme that is weakly effective as an ethanol dehydrogenase, but highly effective as a retinol dehydrogenase ..
  83. pmc Zinc-regulated genes in Saccharomyces cerevisiae revealed by transposon tagging
    D S Yuan
    Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 2631, USA
    Genetics 156:45-58. 2000
    ..protection assays demonstrated four- to eightfold increases for the RNAs of the ZAP1, ZRG17 (YNR039c), DPP1, ADH4, MCD4, and YEF3B genes in zinc-deficient cells...
  84. ncbi Genetic dissection of retinoid dehydrogenases
    G Duester
    Gene Regulation Program, Burnham Institute, 10901 North Torrey Pines Road, 92037, La Jolla, CA, USA
    Chem Biol Interact 130:469-80. 2001
    ..Gene targeting was used to create knockout mice for either Adh1 or Adh4. Both knockout mice were viable and fertile without obvious defects...
  85. ncbi Identification of human liver diacetyl reductases by nano-liquid chromatography/Fourier transform ion cyclotron resonance mass spectrometry
    Y Tanaka
    Biopharmaceutics, Tohoku Pharmaceutical University, 4 1, Komatsushima 4 chome, Aoba ku, Sendai, 981 8558, Japan
    Anal Biochem 293:157-68. 2001
    ..and DAR-7, were identified as alcohol dehydrogenase beta subunit (ADH2), carbonyl reductase (CBR1), and aldehyde reductase (AKR1A1), respectively, by peptide mass fingerprinting...
  86. ncbi Aldo-keto reductases as modulators of stress response
    Qing Chang
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8096, St Louis, MO 63110, USA
    Chem Biol Interact 143:325-32. 2003
    ..knock out is likely to be complicated due to functional compensation by redundant AKRs including AKRs 1A (aldehyde reductase), 1B7 (FR-1) and 1B8 (MVDP)...
  87. ncbi Aldose reductase structures: implications for mechanism and inhibition
    O El-Kabbani
    Department of Medicinal Chemistry, Victorian College of Pharmacy, Monash University, Parkville Campus, 3052 Parkville, Victoria, Australia
    Cell Mol Life Sci 61:750-62. 2004
    ..or adverse side effects attributed to lack of inhibitor specificity and likely inhibition of the related aldehyde reductase (ALR1)...
  88. ncbi Structures of human and porcine aldehyde reductase: an enzyme implicated in diabetic complications
    O El-Kabbani
    The University of Alabama at Birmingham, Center for Macromolecular Crystallography, 35294 0005, USA
    Acta Crystallogr D Biol Crystallogr 50:859-68. 1994
    The crystal structures of porcine and human aldehyde reductase, an enzyme implicated in complications of diabetes, have been determined by X-ray diffraction methods...
  89. ncbi Renal medullary gene expression in aquaporin-1 null mice
    Matthew R McReynolds
    Department of Physiology, College of Medicine, 1501 N Campbell Ave, University of Arizona, Tucson, AZ 85724 5051, USA
    Am J Physiol Renal Physiol 288:F315-21. 2005
    ..Heat shock proteins 105 and 94, aldose reductase, adenylate kinase 2, aldolase B, aldehyde reductase 6, and p8 were decreased in the AQP1 null mice...
  90. ncbi Developmental expression and function of aldehyde reductase in proximal tubules of the kidney
    Oleg A Barski
    Harry B and Aileen Gordon Diabetes Research Laboratory, Baylor College of Medicine, Houston, Texas, USA
    Am J Physiol Renal Physiol 289:F200-7. 2005
    b>Aldehyde reductase reduces a wide variety of toxic and physiological aldehydes with a marked preference for negatively charged substrates such as glucuronate...
  91. ncbi Comparative activities of glutathione-S-transferase and dialdehyde reductase toward aflatoxin B1 in livers of experimental and farm animals
    P Tulayakul
    Laboratory of Veterinary Public Health, Graduate School of Agricultural and Life Sciences, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    Toxicon 46:204-9. 2005
    In order to gain a better understanding of the relative activities of glutathione-S-transferase (GST) and aldehyde reductase toward aflatoxin B1 (AFB1) in relation to the variation of species susceptibilities, we studied the in vitro ..
  92. pmc Identification of a mitochondrial alcohol dehydrogenase in Schizosaccharomyces pombe: new insights into energy metabolism
    Paul G Crichton
    Department of Biochemistry, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    Biochem J 401:459-64. 2007
    ..Using genetic knockouts, we show conclusively that the novel mitochondrial ADH is encoded by adh4 and, as such, is unrelated to ADH isoenzymes found in mitochondria of other yeasts...
  93. ncbi Physico-chemical and thermodynamic aspects of fibroblastic attachment on RGDS-modified chitosan membranes
    Ayşe Gönen Karakeçili
    Hacettepe University, Chemical Engineering Department, 06800 Beytepe, Ankara, Turkey
    Colloids Surf B Biointerfaces 61:216-23. 2008
    ..It can be suggested that, adsorption of serum proteins strongly affected the cell attachment meanwhile the presence of biosignal RGDS molecules triggered the cell spreading in serum medium...
  94. pmc Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat
    Bill D Roebuck
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Toxicol Sci 109:41-9. 2009
    ..These results imply that the prevention of protein adducts mediated by AKR are not critical to protection against AFB(1) tumorigenicity...
  95. pmc Purification, characterization, and potential bacterial wax production role of an NADPH-dependent fatty aldehyde reductase from Marinobacter aquaeolei VT8
    Bradley D Wahlen
    Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, UT 84322 0300, USA
    Appl Environ Microbiol 75:2758-64. 2009
    ..of an enzyme from the wax ester-accumulating bacterium Marinobacter aquaeolei VT8, which is a proposed fatty aldehyde reductase in this pathway...
  96. doi 6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2
    Atsushi Kato
    Department of Hospital Pharmacy, University of Toyama, Toyama 930 0194, Japan
    Bioorg Med Chem Lett 20:5630-3. 2010
    ..We evaluated their ALR2 selectivity profile against sorbitol dehydrogenase and aldehyde reductase (ALR1)...
  97. ncbi The intestinal factor Tff3 and a miRNA network regulate murine caloric metabolism
    Aftab Ali Shah
    Division of Molecular Genetics, Institute of Human Genetics, University of Tubingen, Germany
    RNA Biol 8:77-81. 2011
    ..032), a signaling pathway including nine target genes Aldh9a1, Aldh2, Pck1, Aldoc, Pgam2, Pck2, Adh4, Adh5, and Fbp1...
  98. pmc Molecular and biochemical basis for stress-induced accumulation of free and bound p-coumaraldehyde in cucumber
    Marina Varbanova
    Department of Plant Pathology, Michigan State University, East Lansing, Michigan 48824, USA
    Plant Physiol 157:1056-66. 2011
    ..treatment of cucumber, we observed the rapid accumulation of p-coumaraldehyde, likely the result of low aldehyde reductase activity (i.e. alcohol dehydrogenase in the reverse reaction) of CsCAD enzymes on p-coumaraldehyde...
  99. doi Characterization of a fatty acyl-CoA reductase from Marinobacter aquaeolei VT8: a bacterial enzyme catalyzing the reduction of fatty acyl-CoA to fatty alcohol
    Robert M Willis
    Department of Chemistry and Biochemistry, Utah State University, Logan, Utah 84322, United States
    Biochemistry 50:10550-8. 2011
    ..followed by (ii) reduction of the fatty aldehyde to the corresponding fatty alcohol catalyzed by a fatty aldehyde reductase. Here, we identify, purify, and characterize a novel bacterial enzyme from Marinobacter aquaeolei VT8 that ..
  100. doi Molecular and physiological aspects of alcohol dehydrogenases in the ethanol metabolism of Saccharomyces cerevisiae
    Olga de Smidt
    Department of Microbial, Biochemical and Food Biotechnology, University of the Free State, Bloemfontein, South Africa
    FEMS Yeast Res 12:33-47. 2012
    ..Transcription profiles of the ADH4 and ADH5 genes suggested that participation of these gene products in ethanol production from glucose was unlikely.
  101. pmc Carboxylic acid reductase is a versatile enzyme for the conversion of fatty acids into fuels and chemical commodities
    M Kalim Akhtar
    Department of Biochemistry and Food Chemistry, University of Turku, Tykistökatu 6A 6krs, 20520 Turku, Finland
    Proc Natl Acad Sci U S A 110:87-92. 2013
    ..Together with the broad-substrate specificity of an aldehyde reductase or an aldehyde decarbonylase, the catalytic conversion of fatty acids to fatty alcohols (C(8)-C(16)) or ..

Research Grants30

  1. Protein Modification by 3,4-Dihydroxyphenylacetaldehyde
    JONATHAN DOORN; Fiscal Year: 2006
    ..metabolized primarily to an acid via mitochondrial aldehyde dehydrogenase (ALDH2) but also to an alcohol by aldehyde reductase (ALR). Recent work implicates oxidative stress and lipid peroxidation products, e.g...
  2. ALDO-KETO REDUCTASES AS PART OF CHEMICAL STRESS RESPONSE
    Oleg Barski; Fiscal Year: 2002
    ..Recently it was shown that ethoxyquin and antiobiotic tunicamycin also induce aldehyde reductase, another member of the aldo-keto reductase family...
  3. STRUCTURAL IDENTIFICATION OF PROSTAGLANDIN CONJUGATES
    L Roberts; Fiscal Year: 2000
    ..The ability of PGF-synthase and liver aldehyde reductase to reduce IsoP endoperoxides to F-ring IsoP's will also be examined...
  4. Molecular Mechanisms of Multistage Carcinogenesis
    TREVOR PENNING; Fiscal Year: 2006
    ..Project # 1 (Dr. Penning) will compare the roles of human aldehyde reductase (AKR1A1), CYP1A1/CYP1B1, and CYP-peroxidase in the metabolic activation of PAH using a stable expression ..
  5. ALCOHOL METABOLISM GENES IN TRANSGENIC MICE
    Michael Felder; Fiscal Year: 2007
    ..alcohol-induced liver damage Distal cis-linked sequence in a BAC clone will direct expression of Adh1 in liver and Adh4 in stomach No sequence directing liver expression of any human class I ADH gene is known...
  6. STRUCTURE & EXPRESSION OF MAMMAL ALC DEHYDROGENASE GENES
    Howard Edenberg; Fiscal Year: 2000
    ..The ADH4, ADH5, ADH6 and ADH7 genes have different patterns of expression, and produce enzymes (PI-ADH, X-ADH, ADH6 and ..
  7. Animal Model to Study Retinoic Acid Function in Postnatal and Adult Tissues
    GREGG L DUESTER; Fiscal Year: 2012
    ..e. retinol dehydrogenase-10 (RDH10) and two alcohol dehydrogenases (ADH3 and ADH4)...
  8. Enzyme & Receptor Antagonists of GHB, GBL & 1, 4-BD
    Lawrence Quang; Fiscal Year: 2003
    ..The results of this study will expand upon promising data from pilot studies performed in this laboratory on acute 1,4-BD and GHB toxicity as well as novel therapeutic agents for its potential medical management. ..
  9. Diet, gene-diet interactions and risk of Parkinson's
    Honglei Chen; Fiscal Year: 2004
    ..NHS cohorts, he will evaluate the associations of PD risk with common polymorphisms of NAT2, CYP1A2, ADH2, ADH3, ADH4, and MTHFR...
  10. Alcohol in Israel: Genetic and Environmental Effects
    Deborah Hasin; Fiscal Year: 2007
    ..ADH3 and promoters of ADH4 and ALDH2 will also be studied. Psychiatric comorbidity, religiosity and trauma will be assessed and controlled...
  11. Retinoid Dehydrogenases Involved in Eye Development
    GREGG L DUESTER; Fiscal Year: 2010
    ....
  12. GENETIC DISSECTION OF ALCOHOL/RETINOL METABOLIC PATHWAYS
    Gregg Duester; Fiscal Year: 2002
    ..3) Prepare and ALDH-I knockout mouse plus mice mutated for one or more ADHs and ALDH-I, then analyze their phenotype as above. ..
  13. SPECIFICITY AND FUNCTION OF ALCOHOL DEHYDROGENASES
    BRYCE PLAPP; Fiscal Year: 2004
    ....
  14. Dynamic and Catalysis by Alcohol Dehydrogenases
    BRYCE PLAPP; Fiscal Year: 2009
    ..Design of better inhibitors for treating the pathology of alcoholism depends on understanding the dynamics of catalysis by the rate-limiting enzyme in the pathway of alcohol metabolism. ..
  15. Association and Function of Opioid Receptor Gene Variants to Substance Dependence
    Huiping Zhang; Fiscal Year: 2008
    ..Jeffrey Gruen (co-mentor), who are both excellent supervisors with substantial experience in genetic studies of complex disorders and who have both mentored numerous previous trainees. [unreadable] [unreadable] [unreadable]..
  16. Oxidative Stress, VEGF and Retinopathy
    DAVID VANDER JAGT; Fiscal Year: 2004
    ..It provides a testable model that connects hyperglycemia-> oxidative stress-> growth factors-> diabetic retinopathy. ..
  17. Approaches to the Genetics of Substance Dependence
    Joel Gelernter; Fiscal Year: 2007
    ..This proposal would permit the PI to make a major investment in mentorship, and allow a broadening of his research program in substance dependence. [unreadable] [unreadable] [unreadable] [unreadable]..
  18. Multifunctional Antioxidants as Anti-Cataract Agents
    Peter Kador; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  19. Alopecia and Ulcerative Dermatitis in B6 Mice
    John Sundberg; Fiscal Year: 2007
    ..B6 mice are naturally hypomorphic for alcohol dehydrogenase 4 (Adh4), which may be involved in detoxifying vitamin A metabolites resulting in these enzyme expression ..
  20. PATHOLOGY OF THE LABORATORY MOUSE
    John Sundberg; Fiscal Year: 2006
    ..The Workshop will accommodate 16 participants who will have an opportunity to interact with a group of prominent mouse pathologists and geneticists from both TJL, and other leading institutions. ..
  21. Alcohol: Direct and Indirect Effects in Drug Metabolism
    THOMAS BADGER; Fiscal Year: 2008
    ..abstract_text> ..
  22. RESEARCH TRAINING FOR VETERINARIANS: ANIMAL MODELS
    John Sundberg; Fiscal Year: 2008
    ..The investigators ask to maintain the three slots currently funded. This program is designed to meet the increasing demand for scientists in functional genomics research. ..
  23. Alzheimer's Disease Drugs
    DAVID VANDER JAGT; Fiscal Year: 2008
    ..Versatile schemes to synthesize analogs of resveratrol have been developed. The Specific Aim of this proposal is to test resveratrol and analogs in an animal model of Alzheimer's disease. [unreadable] [unreadable] [unreadable]..
  24. Alcohol Dependence Genetics in a Large Chinese Pedigree
    Joel Gelernter; Fiscal Year: 2008
    ..This study will improve understanding of the genes that influence risk for alcohol dependence, in Chinese populations, and in comparison with European-American populations. [unreadable] [unreadable] [unreadable]..
  25. GENETICS OF COCAINE INDUCED PSYCHOSIS
    Joel Gelernter; Fiscal Year: 2003
    ..This program of research will improve our understanding of the genetics underlying human brain responses to chronic cocaine exposure, thus leading to better diagnosis and treatments for cocaine dependence and other addictive disorders. ..
  26. GENETICS OF COCAINE DEPENDENCE
    Joel Gelernter; Fiscal Year: 2010
    ..The project will also contribute to a substantial increase in our understanding of the mechanisms of CD, and may lead to new approaches to the prevention and treatment of this pervasive societal problem. ..
  27. Fine-mapping the risk loci for alcoholism in ADH gene cluster and ALDH2 gene
    Xingguang Luo; Fiscal Year: 2010
    ..In a word, this study will identify some risk genes for alcohol dependence, helping us better understand the etiology of alcohol dependence and provide potential targets for new drugs. ..
  28. Investigating the Molecular Mechanism of Hexose-induced Stress in Lens and Retina
    Peter F Kador; Fiscal Year: 2010
    ..Moreover, these studies should help identify new drug targets for the treatment of these diabetic complications. ..
  29. SPECIES SUSCEPTIBILITY TO DIABETIC COMPLICATIONS
    KENNETH GABBAY; Fiscal Year: 2002
    ....
  30. ALDO/KETO REDUCTASES AND DIABETIC COMPLICATIONS
    KENNETH GABBAY; Fiscal Year: 2001
    DESCRIPTION (Adapted from applicant's abstract): Aldose and aldehyde reductase are closely related members of the aldo-keto reductase superfamily...