ADGRB3

Summary

Gene Symbol: ADGRB3
Description: adhesion G protein-coupled receptor B3
Alias: BAI3, adhesion G protein-coupled receptor B3, brain-specific angiogenesis inhibitor 3, dJ91B17.1 (brain-specific angiogenesis inhibitor 3)
Species: human

Top Publications

  1. doi C1ql1/Ctrp14 and C1ql4/Ctrp11 promote angiogenesis of endothelial cells through activation of ERK1/2 signal pathway
    Fang Liu
    Key Laboratory for Regenerative Medicine JNU CUHK Ministry of Education, Jinan University, Guangzhou, China
    Mol Cell Biochem 424:57-67. 2017
  2. pmc Bi-allelic Mutations in PKD1L1 Are Associated with Laterality Defects in Humans
    Francesco Vetrini
    Baylor Genetics, Houston, TX 77030, USA
    Am J Hum Genet 99:886-893. 2016
  3. pmc Integrated Analysis of DNA Methylation and mRNA Expression Profiles Data to Identify Key Genes in Lung Adenocarcinoma
    Xiang Jin
    Department of Respiration, The First Hospital of Jilin University, Changchun 130021, China
    Biomed Res Int 2016:4369431. 2016
  4. pmc Targeted promoter editing for rice resistance to Xanthomonas oryzae pv. oryzae reveals differential activities for SWEET14-inducing TAL effectors
    Servane Blanvillain-Baufumé
    UMR Interactions Plantes Microorganismes Environnement IPME, IRD CIRAD Université, Montpellier, France
    Plant Biotechnol J . 2016
  5. pmc Expression of C1ql3 in Discrete Neuronal Populations Controls Efferent Synapse Numbers and Diverse Behaviors
    David C Martinelli
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA Electronic address
    Neuron 91:1034-51. 2016
  6. doi Structures of C1q-like proteins reveal unique features among the C1q/TNF superfamily
    Susanne Ressl
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA Electronic address
    Structure 23:688-99. 2015
  7. pmc International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors
    Jörg Hamann
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands J H Department of Surgery, Research Laboratories G A, and Institute of Biochemistry I L, S P, T S, Medical Faculty, University of Leipzig, Leipzig, Germany Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois D A Department of Nephropathology, Institute of Pathology, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany F B E MRC Centre for Developmental Neurobiology, King s College London, London, United Kingdom C F Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden R F, A K, H B S Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia R A H Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri B L H, K R M Department for Andrology, University Hospital Hamburg Eppendorf, Hamburg, Germany C K Cell and Matrix Biology, Institute of Zoology, Johannes Gutenberg University Mainz, Mainz, Brazil
    Pharmacol Rev 67:338-67. 2015
  8. doi Anterograde C1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum
    Wataru Kakegawa
    Department of Physiology, Keio University School of Medicine, Tokyo 160 8582, Japan Core Research for Evolutional Science and Technology CREST, Japan Science and Technology Agency JST, Tokyo 102 0075, Japan
    Neuron 85:316-29. 2015
  9. pmc Gene mutations in primary tumors and corresponding patient-derived xenografts derived from non-small cell lung cancer
    Chuncheng Hao
    Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Lett 357:179-85. 2015
  10. pmc The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family
    Manishha Patel
    Institut de Recherches Cliniques de Montreal, Quebec H2W 1R7, Canada
    J Biol Chem 286:38969-79. 2011

Scientific Experts

  • Susanne Ressl
  • Pamela DeRosse
  • David C Martinelli
  • Fang Liu
  • Servane Blanvillain-Baufumé
  • Francesco Vetrini
  • Xiang Jin
  • Wataru Kakegawa
  • Jörg Hamann
  • Chuncheng Hao
  • Muhammad F Bari
  • Noumeira Hamoud
  • Boris Szurek
  • Ralf Koebnik
  • Jens Boch
  • Thomas C Sudhof
  • V Lanoue
  • Viviane Tran
  • Jean Francois Cote
  • Jingui Duan
  • Chen Wu
  • Marc F Bolliger
  • Manishha Patel
  • Yanhua Yu
  • Zhengyan Kan
  • G Antoni
  • Junko Ito
  • Vahe Michael Zohrabian
  • Hae Jin Kee
  • Anni Tan
  • Xuesong Yang
  • Yingzi Xue
  • Yanhong Yu
  • Luanjuan Xiao
  • Renhao Yang
  • Lei Chen
  • Ming Zhang
  • Jignesh Chandarana
  • Asha Rijhsinghani
  • Tamar Harel
  • Mohammad K Eldomery
  • Alicia Braxton
  • Axel T Brunger
  • Judy Holtzman
  • Donna M Muzny
  • Hinda Doucoure
  • Mahshid S Azamian
  • Chelsea Kois
  • Natasha Shur
  • Virginia Sack
  • Neil A Hanchard
  • Samer Hattar
  • Markus Missler
  • Christine M Eng
  • Donaldo Meynard
  • Xiaodan Li
  • Zeynep C Akdemir
  • Murielle Portefaix
  • Kylie S Chew
  • Astrid Rohlmann
  • Shalini N Jhangiani
  • James R Lupski
  • Yinghui Guan
  • Sébastien Cunnac
  • Yan Ding
  • Yaping Yang
  • Balveen Kaur
  • Matthew Y Lum
  • Emmanuel Guiderdoni
  • Montserrat Sole
  • Xingang Liu
  • Kathryn Miller
  • Florence Auguy
  • Lisa C A D'Alessandro
  • John W Belmont
  • Maik Reschke
  • Jill A Rosenfeld
  • Richard A Gibbs
  • Xiao Huang
  • Kenna R Shaw
  • Qingxiu Zhang
  • Mengru Cao
  • Barbara Knapp
  • Ara Vaporciyan
  • Arunkumar Krishnan
  • Martin Stacey
  • Randy A Hall
  • Kelly R Monk
  • Shin Ichi Muramatsu
  • Junko Motohashi

Detail Information

Publications25

  1. doi C1ql1/Ctrp14 and C1ql4/Ctrp11 promote angiogenesis of endothelial cells through activation of ERK1/2 signal pathway
    Fang Liu
    Key Laboratory for Regenerative Medicine JNU CUHK Ministry of Education, Jinan University, Guangzhou, China
    Mol Cell Biochem 424:57-67. 2017
    ..Moreover, the immunoreactivity of the receptor of C1QL1-C1QL4, brain-specific angiogenesis inhibitor 3 (BAI3), is detected in HUVECs, suggesting that BAI3 may mediate C1QL1/CTRP14- and C1QL4/CTRP11-induced angiogenesis...
  2. pmc Bi-allelic Mutations in PKD1L1 Are Associated with Laterality Defects in Humans
    Francesco Vetrini
    Baylor Genetics, Houston, TX 77030, USA
    Am J Hum Genet 99:886-893. 2016
    ..of this conserved cysteine residue in the GPS motif have also been reported in other genes, namely GPR56, BAI3, and PKD1 in human and lat-1 in C. elegans, further supporting the likely pathogenicity of p.Cys1691Ser in PKD1L1...
  3. pmc Integrated Analysis of DNA Methylation and mRNA Expression Profiles Data to Identify Key Genes in Lung Adenocarcinoma
    Xiang Jin
    Department of Respiration, The First Hospital of Jilin University, Changchun 130021, China
    Biomed Res Int 2016:4369431. 2016
    ..And there were 29 LAC-associated methylation sites located in 27 DEGs (e.g., SH3GL2, BAI3, CDH13, JAM2, MT1A, LHX6, and IGFBP3). Conclusions. These key genes might play a role in pathogenesis of LAC.
  4. pmc Targeted promoter editing for rice resistance to Xanthomonas oryzae pv. oryzae reveals differential activities for SWEET14-inducing TAL effectors
    Servane Blanvillain-Baufumé
    UMR Interactions Plantes Microorganismes Environnement IPME, IRD CIRAD Université, Montpellier, France
    Plant Biotechnol J . 2016
    ..Surprisingly, although indels within TalC EBE prevented OsSWEET14 induction in response to BAI3 wild-type bacteria relying on TalC, loss of TalC responsiveness failed to confer resistance to this strain...
  5. pmc Expression of C1ql3 in Discrete Neuronal Populations Controls Efferent Synapse Numbers and Diverse Behaviors
    David C Martinelli
    Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA Electronic address
    Neuron 91:1034-51. 2016
    C1ql3 is a secreted neuronal protein that binds to BAI3, an adhesion-class GPCR. C1ql3 is homologous to other gC1q-domain proteins that control synapse numbers, but a role for C1ql3 in regulating synapse density has not been demonstrated...
  6. doi Structures of C1q-like proteins reveal unique features among the C1q/TNF superfamily
    Susanne Ressl
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA Electronic address
    Structure 23:688-99. 2015
    ..C1QLs bind to brain-specific angiogenesis inhibitor 3 (BAI3), an adhesion-type G-protein coupled receptor that may regulate dendritic morphology by organizing actin filaments...
  7. pmc International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors
    Jörg Hamann
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands J H Department of Surgery, Research Laboratories G A, and Institute of Biochemistry I L, S P, T S, Medical Faculty, University of Leipzig, Leipzig, Germany Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois D A Department of Nephropathology, Institute of Pathology, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany F B E MRC Centre for Developmental Neurobiology, King s College London, London, United Kingdom C F Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden R F, A K, H B S Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia R A H Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri B L H, K R M Department for Andrology, University Hospital Hamburg Eppendorf, Hamburg, Germany C K Cell and Matrix Biology, Institute of Zoology, Johannes Gutenberg University Mainz, Mainz, Brazil
    Pharmacol Rev 67:338-67. 2015
    ..names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ..
  8. doi Anterograde C1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum
    Wataru Kakegawa
    Department of Physiology, Keio University School of Medicine, Tokyo 160 8582, Japan Core Research for Evolutional Science and Technology CREST, Japan Science and Technology Agency JST, Tokyo 102 0075, Japan
    Neuron 85:316-29. 2015
    ..C1ql1 specifically binds to the brain-specific angiogenesis inhibitor 3 (Bai3), which is a member of the cell-adhesion G-protein-coupled receptor family and expressed on postsynaptic Purkinje ..
  9. pmc Gene mutations in primary tumors and corresponding patient-derived xenografts derived from non-small cell lung cancer
    Chuncheng Hao
    Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Lett 357:179-85. 2015
    ..Other genes with deleterious mutations in ≥3 (13.0%) primary tumors were MLL3, SETD2, ATM, ARID1A, CRIPAK, HGF, BAI3, EP300, KDR, PDGRRA and RUNX1...
  10. pmc The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family
    Manishha Patel
    Institut de Recherches Cliniques de Montreal, Quebec H2W 1R7, Canada
    J Biol Chem 286:38969-79. 2011
    ..Furthermore, via binding of an Arf family GTPase, the ELMO-DOCK180 is uniquely positioned at the membrane to activate Rac signaling and remodel the actin cytoskeleton...
  11. pmc G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates
    Noumeira Hamoud
    Institut de Recherches Cliniques de Montreal, Montreal, QC, Canada H2W 1R7
    Proc Natl Acad Sci U S A 111:3745-50. 2014
    ..regulators of myoblast fusion, we identified the G-protein coupled receptor brain-specific angiogenesis inhibitor (BAI3) as a cell surface protein that interacts with ELMO...
  12. ncbi Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)
    T Shiratsuchi
    Laboratory of Molecular Medicine, Human Genome Center, University of Tokyo, Japan
    Cytogenet Cell Genet 79:103-8. 1997
    ..Like BAI1, these two genes, designated BAI2 and BAI3, were specifically expressed in brain, and are likely to be expressed in the same type of cells...
  13. doi BAI3, CDX2 and VIL1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas
    Muhammad F Bari
    Department of Pathology, Dow International Medical College, Karachi, Pakistan Department of Pathology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK Divisions of Reproduction and Metabolic and Vascular Health, Warwick Medical School, Coventry, UK
    Histopathology 64:547-56. 2014
    ..We aimed to identify immunohistochemical markers to assist this diagnosis...
  14. ncbi Highly selective CO2 capture of an agw-type metal-organic framework with inserted amides: experimental and theoretical studies
    Jingui Duan
    State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P R China
    Chem Commun (Camb) 48:3058-60. 2012
    An amide-inserted metal-organic framework (NJU-Bai3) presents high storage and high selectivity toward CO(2) and combines these two interesting characters which strongly support our expectation that amide groups can significantly enhance ..
  15. pmc The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons
    V Lanoue
    Center for Interdisciplinary Research in Biology, College de France, Paris, France
    Mol Psychiatry 18:943-50. 2013
    ..Our results, obtained using expression knockdown and overexpression experiments, reveal that the BAI3 receptor controls dendritic arborization growth and branching in cultured neurons...
  16. doi Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations
    Chen Wu
    State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Nat Genet 44:62-6. 2011
    ..1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer...
  17. doi Colonization of rice leaf blades by an African strain of Xanthomonas oryzae pv. oryzae depends on a new TAL effector that induces the rice nodulin-3 Os11N3 gene
    Yanhua Yu
    Laboratoire Génome et Développement des Plantes, Montpellier, France
    Mol Plant Microbe Interact 24:1102-13. 2011
    ..oryzae pv. oryzae BAI3. A strain mutated in talC was severely affected in the production of disease symptoms...
  18. pmc The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins
    Marc F Bolliger
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 108:2534-9. 2011
    ..b>BAI3 protein, in contrast, is a member of the cell-adhesion class of G protein-coupled receptors that are expressed at ..
  19. doi A multi-stage multi-design strategy provides strong evidence that the BAI3 locus is associated with early-onset venous thromboembolism
    G Antoni
    INSERM UMRS 937, Universite Pierre et Marie Curie, Paris, France
    J Thromb Haemost 8:2671-9. 2010
    ..Factor VIII (FVIII) and von Willebrand factor (VWF) are two known quantitative risk factors for venous thromboembolism (VTE)...
  20. doi Diverse somatic mutation patterns and pathway alterations in human cancers
    Zhengyan Kan
    Department of Molecular Biology, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 466:869-73. 2010
    ..identified 77 significantly mutated genes including protein kinases, G-protein-coupled receptors such as GRM8, BAI3, AGTRL1 (also called APLNR) and LPHN3, and other druggable targets...
  21. doi Anatomical and histological profiling of orphan G-protein-coupled receptor expression in gastrointestinal tract of C57BL/6J mice
    Junko Ito
    Departments of Metabolic Disorder Research, Tsukuba Research Institute, Banyu Pharmaceutical, Okubo 3, Tsukuba, Ibaraki 300 2611, Japan
    Cell Tissue Res 338:257-69. 2009
    ..GPR85, GPR37, GPR37L1, brain-specific angiogenesis inhibitor (BAI) 1, BAI2, BAI3, and GPRC5B mRNAs were preferentially expressed in the muscle-myenteric nerve layer, similar to GPCRs that are ..
  22. pmc The genetics of symptom-based phenotypes: toward a molecular classification of schizophrenia
    Pamela DeRosse
    Center for Translational Psychiatry, The Feinstein Institute for Medical Research, Manhasset, NY, USA
    Schizophr Bull 34:1047-53. 2008
    ..We examined these chromosomal regions for association to positive, negative, and disorganized symptom clusters, using a dense set of single-nucleotide polymorphisms (SNPs)...
  23. ncbi Gene expression profiling of metastatic brain cancer
    Vahe Michael Zohrabian
    Department of Neurosurgery, New York Medical College, Valhalla, NY 10595, USA
    Oncol Rep 18:321-8. 2007
    ..Brain-specific angiogenesis inhibitors 1 and 3 (BAI1 and BAI3) were underexpressed as well...
  24. ncbi Expression of brain-specific angiogenesis inhibitor 3 (BAI3) in normal brain and implications for BAI3 in ischemia-induced brain angiogenesis and malignant glioma
    Hae Jin Kee
    Research Institute of Medical Sciences and Medical Research Center for Gene Regulation, Chonnam National University Medical School, Kwangju 501 190, Republic of Korea
    FEBS Lett 569:307-16. 2004
    ..In situ hybridization analyses of the brain showed the same localization of BAI3 as BAI1 and BAI2, which includes most neurons of cerebral cortex and hippocampus...
  25. pmc Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression
    Balveen Kaur
    Laboratory of Molecular Neuro Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia 30322, USA
    Am J Pathol 162:19-27. 2003
    ..BAI1 mRNA is expressed mainly in the brain, while BAI2 and BAI3 mRNAs are more widely expressed...