adenosine deaminase

Summary

Gene Symbol: adenosine deaminase
Description: adenosine deaminase
Alias: adenosine deaminase, adenosine aminohydrolase
Species: human

Top Publications

  1. ncbi [Serum adenosine deaminase as a parameter for activity in sarcoidosis]
    E Wetzel
    Krankenanstalt, , Akademisches Lehrkrankenhaus,
    Pneumologie 53:323-8. 1999
  2. ncbi Type 2 diabetes and the genetics of signal transduction: a study of interaction between adenosine deaminase and acid phosphatase locus 1 polymorphisms
    N Bottini
    Program of Signal Transduction, The Burnham Institute, La Jolla, CA, USA
    Metabolism 53:995-1001. 2004
  3. ncbi Interactions among adenosine deaminase, adenosine A(1) receptors and dopamine D(1) receptors in stably cotransfected fibroblast cells and neurons
    M Torvinen
    Department of Neuroscience, Karolinska Institute, 171 77, Stockholm, Sweden
    Neuroscience 113:709-19. 2002
  4. ncbi Clustered charged amino acids of human adenosine deaminase comprise a functional epitope for binding the adenosine deaminase complexing protein CD26/dipeptidyl peptidase IV
    Eva Richard
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:19720-6. 2002
  5. ncbi [Differences between management guidelines and global health strategies for arterial hypertension with metabolic disorders in France in 1999. Ohara study]
    J M Mallion
    CHU Michallon, 38043 Grenoble
    Arch Mal Coeur Vaiss 94:834-8. 2001
  6. ncbi HIV-1 envelope gp120 and viral particles block adenosine deaminase binding to human CD26
    A Valenzuela
    Departament de Bioquimica i Biologia Molecular, Facultad de Quimica, Universidad de Barcelona, Spain
    Adv Exp Med Biol 421:185-92. 1997
  7. ncbi Gene-expression profiling reveals down-regulation of equilibrative nucleoside transporter 1 (ENT1) in Ara-C-resistant CCRF-CEM-derived cells
    Kazuchika Takagaki
    Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, 3 14 1 Sakura, Tsukuba, Ibaraki 305 0003, Japan
    J Biochem 136:733-40. 2004
  8. ncbi Type 1 diabetes: evidence of interaction between ACP1 and ADA1 gene polymorphisms
    Patrizia Saccucci
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Med Sci Monit 15:CR511-517. 2009
  9. doi Human adenosine deaminase as an allosteric modulator of human A(1) adenosine receptor: abolishment of negative cooperativity for [H](R)-pia binding to the caudate nucleus
    Eduard Gracia
    Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, University of Barcelona, Spain
    J Neurochem 107:161-70. 2008
  10. ncbi Adenosine deaminase 1 and concentrative nucleoside transporters 2 and 3 regulate adenosine on the apical surface of human airway epithelia: implications for inflammatory lung diseases
    Andrew J Hirsh
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Biochemistry 46:10373-83. 2007

Research Grants

  1. Novel SCID rat models for human cell transplantation studies
    Joseph C Ruiz; Fiscal Year: 2010
  2. Adenosine Deaminase, Adenosine Signaling and Disease
    RODNEY KELLEMS; Fiscal Year: 2006
  3. Purine Pathways and Inhibitor Design in Plasmodium
    Vern L Schramm; Fiscal Year: 2012
  4. Donald B Kohn; Fiscal Year: 2016
  5. Adenosine Signaling, Priapism and Sickle Cell Disease
    Yang Xia; Fiscal Year: 2012
  6. Gene Therapy for Purine Nucleoside Phosphorylase Deficiency (PNP)
    Kevin Baker; Fiscal Year: 2007
  7. TRANSLATIONAL CONTROL OF ADENOSINE DEAMINASE
    Elaine Chottiner; Fiscal Year: 1990
  8. ACTIVATION OF IMMUNOCOMPETENT LYMPHOCYTES
    Rochelle Hirschhorn; Fiscal Year: 1999
  9. IMMUNODEFICIENCY AND ADA DEFICIENCY--MOLECULAR ANALYSIS
    MARY MARKERT; Fiscal Year: 1990
  10. MOLECULAR REGULATION OF ADENOSINE IN RELATION TO SLEEP
    Miroslaw Mackiewicz; Fiscal Year: 2000

Detail Information

Publications277 found, 100 shown here

  1. ncbi [Serum adenosine deaminase as a parameter for activity in sarcoidosis]
    E Wetzel
    Krankenanstalt, , Akademisches Lehrkrankenhaus,
    Pneumologie 53:323-8. 1999
    ..In comparison to the other parameters, measurement of the serum ADA indicates a greater discrimination between active and inactive disease...
  2. ncbi Type 2 diabetes and the genetics of signal transduction: a study of interaction between adenosine deaminase and acid phosphatase locus 1 polymorphisms
    N Bottini
    Program of Signal Transduction, The Burnham Institute, La Jolla, CA, USA
    Metabolism 53:995-1001. 2004
    ..b>Adenosine deaminase (ADA) is a polymorphic enzyme that catalyses the irreversible deamination of adenosine to inosine and has ..
  3. ncbi Interactions among adenosine deaminase, adenosine A(1) receptors and dopamine D(1) receptors in stably cotransfected fibroblast cells and neurons
    M Torvinen
    Department of Neuroscience, Karolinska Institute, 171 77, Stockholm, Sweden
    Neuroscience 113:709-19. 2002
    The role of adenosine deaminase in the interactions between adenosine A(1) and dopamine D(1) receptors was studied in a mouse fibroblast cell line stably cotransfected with human D(1) receptor and A(1) receptor cDNAs (A(1)D(1) cells)...
  4. ncbi Clustered charged amino acids of human adenosine deaminase comprise a functional epitope for binding the adenosine deaminase complexing protein CD26/dipeptidyl peptidase IV
    Eva Richard
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:19720-6. 2002
    Human adenosine deaminase (ADA) occurs as a 41-kDa soluble monomer in all cells. On epithelia and lymphoid cells of humans, but not mice, ADA also occurs bound to the membrane glycoprotein CD26/dipeptidyl peptidase IV...
  5. ncbi [Differences between management guidelines and global health strategies for arterial hypertension with metabolic disorders in France in 1999. Ohara study]
    J M Mallion
    CHU Michallon, 38043 Grenoble
    Arch Mal Coeur Vaiss 94:834-8. 2001
    ..As a conclusion, to improve the prognosis of hypertensive patients, it is mandatory to raise the awareness of physicians about multiple risk factor management and help them implement the recommendations in their daily practice...
  6. ncbi HIV-1 envelope gp120 and viral particles block adenosine deaminase binding to human CD26
    A Valenzuela
    Departament de Bioquimica i Biologia Molecular, Facultad de Quimica, Universidad de Barcelona, Spain
    Adv Exp Med Biol 421:185-92. 1997
    CD26, known to be the adenosine deaminase (ADA) binding protein, has been implicated in HIV infection...
  7. ncbi Gene-expression profiling reveals down-regulation of equilibrative nucleoside transporter 1 (ENT1) in Ara-C-resistant CCRF-CEM-derived cells
    Kazuchika Takagaki
    Discovery Research Laboratories, Nippon Shinyaku Co, Ltd, 3 14 1 Sakura, Tsukuba, Ibaraki 305 0003, Japan
    J Biochem 136:733-40. 2004
    ..The adenosine deaminase (ADA) gene was highly up-regulated in Ara-C-resistant cells, while equilibrative nucleoside transporter 1 (..
  8. ncbi Type 1 diabetes: evidence of interaction between ACP1 and ADA1 gene polymorphisms
    Patrizia Saccucci
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Med Sci Monit 15:CR511-517. 2009
    ACP1 (acid phosphatase locus 1, a cytosolic low-molecular-weight phosphotyrosin phosphatase) and ADA1 (adenosine deaminase locus 1) are two polymorphic systems involved in immune reactions...
  9. doi Human adenosine deaminase as an allosteric modulator of human A(1) adenosine receptor: abolishment of negative cooperativity for [H](R)-pia binding to the caudate nucleus
    Eduard Gracia
    Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, University of Barcelona, Spain
    J Neurochem 107:161-70. 2008
    It has been shown that adenosine deaminase (ADA; EC 3.5.4.4) behaves as an ecto-enzyme anchored to membrane proteins, among them A(1) adenosine receptors (A(1)Rs)...
  10. ncbi Adenosine deaminase 1 and concentrative nucleoside transporters 2 and 3 regulate adenosine on the apical surface of human airway epithelia: implications for inflammatory lung diseases
    Andrew J Hirsh
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Biochemistry 46:10373-83. 2007
    ..The conversion of adenosine to inosine was completely inhibited by the adenosine deaminase 1 (ADA1) inhibitor erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA)...
  11. pmc The genetics of feto-placental development: a study of acid phosphatase locus 1 and adenosine deaminase polymorphisms in a consecutive series of newborn infants
    Fulvia Gloria-Bottini
    Department of Biopathology and Imaging Diagnostics, Division of Human Population Biopathology and Environmental Pathology, University of Rome Tor Vergata, Rome, Italy
    Reprod Biol Endocrinol 6:38. 2008
    Acid phosphatase locus 1 and adenosine deaminase locus 1 polymorphisms show cooperative effects on glucose metabolism and immunological functions...
  12. ncbi An Asp8Asn substitution results in the adenosine deaminase (ADA) genetic polymorphism (ADA 2 allozyme): occurrence on different chromosomal backgrounds and apparent intragenic crossover
    R Hirschhorn
    New York University Medical Center, Department of Medicine, NY 10016
    Ann Hum Genet 58:1-9. 1994
    We have now determined the molecular genetic basis for the common biochemical polymorphism at the adenosine deaminase (ADA) locus...
  13. ncbi Direct association of adenosine deaminase with a T cell activation antigen, CD26
    J Kameoka
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA
    Science 261:466-9. 1993
    ..acid sequence analysis and immunoprecipitation studies demonstrated that this 43-kilodalton protein was adenosine deaminase (ADA)...
  14. ncbi The HIV-1 gp120 inhibits the binding of adenosine deaminase to CD26 by a mechanism modulated by CD4 and CXCR4 expression
    J Blanco
    Unité de Virologie et dImmunologie Cellulaire, ERS 572 CNRS, Institut Pasteur, 28 rue Dr Roux, 75724 Paris Cedex 15, France
    FEBS Lett 477:123-8. 2000
    HIV-1 external envelope glycoprotein gp120 inhibits adenosine deaminase (ADA) binding to its cell surface receptor in lymphocytes, CD26, by a mechanism that does not require the gp120-CD4 interaction...
  15. ncbi Adenosine A2B receptors behave as an alternative anchoring protein for cell surface adenosine deaminase in lymphocytes and cultured cells
    C Herrera
    Department of Biochemistry and Molecular Biology, Faculty of Chemistry, University of Barcelona, Barcelona, Spain
    Mol Pharmacol 59:127-34. 2001
    b>Adenosine deaminase (ADA) is an enzyme of the purine metabolism that has been largely considered to be cytosolic...
  16. pmc CD26, adenosine deaminase, and adenosine receptors mediate costimulatory signals in the immunological synapse
    R Pacheco
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain
    Proc Natl Acad Sci U S A 102:9583-8. 2005
    b>Adenosine deaminase (ADA), a protein whose deficit leads to severe combined immunodeficiency, binds to the cell surface by means of either CD26, A(1) adenosine receptors, or A(2B) adenosine receptors...
  17. pmc Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26
    Holger K Eltzschig
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
    Blood 108:1602-10. 2006
    ..Guided by microarray results revealing induction of endothelial adenosine deaminase (ADA) mRNA in hypoxia, we used in vitro and in vivo models of adenosine signaling, confirming induction of ..
  18. ncbi ADA*2 allele of the adenosine deaminase gene may protect against coronary artery disease
    Krzysztof Safranow
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
    Cardiology 108:275-81. 2007
    The common G22A polymorphism in the adenosine deaminase (ADA) gene leads to substitution Asp8Asn...
  19. pmc Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients
    Barbara Cassani
    San Raffaele Telethon Institute for Gene Therapy, Milan, Italy
    Blood 111:4209-19. 2008
    Mutations in the adenosine deaminase (ADA) gene are responsible for a form of severe combined immunodeficiency (SCID) caused by the lymphotoxic accumulation of ADA substrates, adenosine and 2'-deoxy-adenosine...
  20. doi The 22G>A polymorphism in the adenosine deaminase gene impairs catalytic function but does not affect reactive hyperaemia in humans in vivo
    Niels P Riksen
    Departments of Pharmacology Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Pharmacogenet Genomics 18:843-6. 2008
    ..b>Adenosine deaminase (ADA) is an enzyme that catalyzes the irreversible deamination of adenosine...
  21. doi Adenosine deaminase enhances T-cell response elicited by dendritic cells loaded with inactivated HIV
    Nuria Climent
    Hospital Clinic, Barcelona, Spain
    Immunol Cell Biol 87:634-9. 2009
    ..Owing to the fact that adenosine deaminase (ADA) is a member of the family of growth factor with deaminase activity, we tested whether it could ..
  22. pmc Adenosine deaminase modulation of telomerase activity and replicative senescence in human CD8 T lymphocytes
    Stanley T Parish
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Immunol 184:2847-54. 2010
    ..The present study investigates the role of a second T cell costimulatory receptor component, adenosine deaminase (ADA), on the process of replicative senescence...
  23. doi Gender-specific association of ADA genetic polymorphism with human longevity
    Valerio Napolioni
    Department of Molecular, Cellular and Animal Biology, University of Camerino, Italy
    Biogerontology 11:457-62. 2010
    Aim of this study was to investigate whether the polymorphic ADA (Adenosine Deaminase, EC 3.5.4...
  24. doi Contribution of adenosine related genes to the risk of depression with disturbed sleep
    Natalia Gass
    Department of Physiology, Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    J Affect Disord 126:134-9. 2010
    ..One of the key substances regulating sleep is adenosine. We hypothesized that variations in polymorphic sites of adenosine related genes may predispose to depression with sleep disturbances...
  25. ncbi Lower frequency of the low activity adenosine deaminase allelic variant (ADA1*2) in schizophrenic patients
    Gustavo Pimentel Dutra
    Department of Celular and Molecular Biology, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Rev Bras Psiquiatr 32:275-8. 2010
    ..b>Adenosine deaminase participates in purine metabolism by converting adenosine into inosine...
  26. doi Human adenosine deaminase 2 induces differentiation of monocytes into macrophages and stimulates proliferation of T helper cells and macrophages
    Andrey V Zavialov
    Institut National de la Santé et de la Recherche Médicale U924, Univesity of Nice Sophia Antipolis, Valbonne, France
    J Leukoc Biol 88:279-90. 2010
    ..Our discovery of the growth factor-like activity of ADA2 explains clinical observations and suggests that this enzyme could be used as a drug candidate to modulate the immune responses during inflammation and cancer...
  27. doi Age- and gender-specific association between ADA (22G>A) and TNF-α (-308G>A) genetic polymorphisms
    V Napolioni
    Laboratory of Human Genetics, Department of Molecular, Cellular and Animal Biology, University of Camerino, Camerino, Italy
    Tissue Antigens 76:311-4. 2010
    ..In the present study, we evaluated the genetic relationship between the functional adenosine deaminase (ADA) (22G>A, rs73598374) and TNF-α (-308G>A, rs1800629) SNPs in a healthy population from central ..
  28. doi Adenosine deaminase potentiates the generation of effector, memory, and regulatory CD4+ T cells
    José M Martinez-Navio
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Spain
    J Leukoc Biol 89:127-36. 2011
    ..These data suggest that ADA is a relevant modulator of CD4+ T cell differentiation, even in cells from immunologically compromised individuals...
  29. pmc Effects of the adenosine deaminase polymorphism and caffeine intake on sleep parameters in a large population sample
    Diego Robles Mazzotti
    Departmento de Psicobiologia, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Sleep 34:399-402. 2011
    To evaluate the association between the adenosine deaminase polymorphism, sleep architecture, and caffeine consumption.
  30. doi Functional ADA polymorphism increases sleep depth and reduces vigilant attention in humans
    Valérie Bachmann
    Institute of Pharmacology and Toxicology University of Zurich, Zurich, Switzerland
    Cereb Cortex 22:962-70. 2012
    ..The nonsynonymous c.22G>A polymorphism (rs73598374) of adenosine deaminase (ADA) reduces the conversion of adenosine to inosine and predicts baseline differences in sleep slow-wave ..
  31. doi Molecular mechanism and structural basis of interactions of dipeptidyl peptidase IV with adenosine deaminase and human immunodeficiency virus type-1 transcription transactivator
    Hua Fan
    Institut fur Biochemie und Molekularbiologie, Charite Universitatsmedizin Berlin, Arnimallee 22, 14195 Berlin Dahlem, Germany
    Eur J Cell Biol 91:265-73. 2012
    ..In this paper, we review our recent studies on the interactions of DPPIV with adenosine deaminase (ADA) and the transcription transactivator of the human immunodeficiency virus type-1 (HIV-1 Tat) as ..
  32. doi Age- and gender-specific epistasis between ADA and TNF-α influences human life-expectancy
    Valerio Napolioni
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Rome, Italy
    Cytokine 56:481-8. 2011
    ..we examined the main effects of single loci and multi-locus interactions to test the hypothesis that the adenosine deaminase (ADA) and tumor necrosis factor alpha (TNF-α) genes may influence human life-expectancy...
  33. pmc Adenosine deaminase polymorphism affects sleep EEG spectral power in a large epidemiological sample
    Diego Robles Mazzotti
    Departamento de Psicobiologia, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 7:e44154. 2012
    ..Adenosine is strongly implicated in sleep homeostasis, and a single nucleotide polymorphism in the adenosine deaminase gene (ADA G22A) has been associated with deeper and more efficient sleep...
  34. doi Insights into behavioral vulnerability to differential sleep pressure and circadian phase from a functional ADA polymorphism
    Carolin F Reichert
    Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland
    J Biol Rhythms 29:119-30. 2014
    ..40 h multiple naps), we investigated the influence of a human adenosine deaminase (ADA) polymorphism (rs73598374) on several behavioral measures throughout nearly 2 circadian cycles...
  35. ncbi Expression of ecto-adenosine deaminase and CD26 in human T cells triggered by the TCR-CD3 complex. Possible role of adenosine deaminase as costimulatory molecule
    M Martin
    Department of Biochemistry and Molecular Biology, University of Barcelona, Catalonia, Spain
    J Immunol 155:4630-43. 1995
    The expression of surface adenosine deaminase (ADA) and CD26 in activated human T cells was studied by flow cytometry...
  36. ncbi Adenosine deaminase binding to human CD26 is inhibited by HIV-1 envelope glycoprotein gp120 and viral particles
    A Valenzuela
    Department of Biochemistry and Molecular Biology, Faculty of Chemistry, University of Barcelona, Catalonia, Spain
    J Immunol 158:3721-9. 1997
    CD26, known to be the adenosine deaminase (ADA)-binding protein, has been implicated in HIV infection...
  37. pmc A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans
    J V Rétey
    Institute of Pharmacology and Toxicology and Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 102:15676-81. 2005
    ..Here we show in humans that a genetic variant of adenosine deaminase, which is associated with the reduced metabolism of adenosine to inosine, specifically enhances deep sleep ..
  38. pmc Stimulation of human umbilical vein endothelial cell proliferation by A2-adenosine and beta 2-adrenoceptors
    V Sexl
    Institute of Pharmacology, University of Vienna, Austria
    Br J Pharmacol 114:1577-86. 1995
    ..3. In the presence of adenosine deaminase (ADA), which was used to remove adenosine present in the culture medium, the adenosine receptor agonists N-..
  39. pmc Effects of acute and chronic ethanol on cyclic AMP accumulation in NG108-15 cells: differential dependence of changes on extracellular adenosine
    E Kelly
    Department of Pharmacology, School of Medical Sciences, University of Bristol
    Br J Pharmacol 114:1433-41. 1995
    ..However, chronic ethanol did not affect [3H]-iloprost binding to cell membranes. 4. Inclusion of adenosine deaminase (ADA; 1 unit ml-1) during the incubation period to measure cyclic AMP accumulation completely abolished the ..
  40. ncbi Different effect of dGTP on 2'-deoxyadenosine metabolism in mitochondria and cytosol
    J Greger
    Department of Biochemistry, , Poland
    Z Naturforsch C 47:893-7. 1992
    Two enzymes participating in 2'-deoxyadenosine (dAdo) metabolism: dAdo kinase (dAdoK EC 2.7.1.76) and adenosine deaminase (ADA, EC 3.5.4...
  41. ncbi Prothymosin alpha and factors from calf thymic cells decrease expression of Thy 1.2 antigen among small thymocytes from C57BL/6 mice
    P Barja
    , , Universidad de Santiago, Santiago de Compostela, Spain
    Immunopharmacol Immunotoxicol 16:403-18. 1994
    ..2 antigen (a T-cell marker) and the activities of adenosine deaminase (ADA, E.C. 3.5.4.4), N-acetyl-beta-D-glucosaminidase (NABG, E.C. 3.2.1.30), beta-glucuronidase (BG, E.C. 3...
  42. ncbi [A case of pneumonia due to Mycoplasma pneumoniae accompanying high adenosine deaminase activity in pleural effusion]
    S Tokisawa
    Omuta Kinen Hospital
    Kansenshogaku Zasshi 66:995-7. 1992
    We experienced a 5-year-old male case of Mycoplasma pneumoniae pneumonia accompanying Adenosine Deaminase (ADA) activity in pleural effusion...
  43. ncbi Biologic relevance of elevated red cell adenosine deaminase activity in myelodysplastic syndromes and paroxysmal nocturnal hemoglobinuria
    P Di Marco
    Cattedra di Ematologia, , Italy
    Tumori 78:370-3. 1992
    Red cell adenosine deaminase (ADA-RBC) activity in patients with myelodysplastic syndromes and paroxysmal nocturnal hemoglobinuria is significantly increased compared to that observed in normal controls...
  44. ncbi [Role of serum adenosine deaminase as an immune parameter of tuberculosis]
    C Kelbel
    , Akademisches Lehrkrankenhaus,
    Pneumologie 49:684-8. 1995
    ..Serum levels positively correlated to the disease extent in tuberculosis of immunocompetent patients. This marker deserves further investigation with respect to its clinical significance...
  45. ncbi High-performance liquid chromatographic method for the simultaneous detection of malonaldehyde, acetaldehyde, formaldehyde, acetone and propionaldehyde to monitor the oxidative stress in heart
    G A Cordis
    University of Connecticut School of Medicine, Farmington 06030-1110
    J Chromatogr A 661:181-91. 1994
    ..Since MDA, FDA, ADA, acetone, and PDA are the products of ODFR-PUFA interactions, this method allows proper estimation of LPO which monitors the oxidative stress developed during the reperfusion of ischemic myocardium...
  46. ncbi Identification and characterization of a salivary adenosine deaminase from the sand fly Phlebotomus duboscqi, the vector of Leishmania major in sub-Saharan Africa
    Hirotomo Kato
    Vector Molecular Biology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Exp Biol 210:733-40. 2007
    Two transcripts coding for an adenosine deaminase (ADA) were identified by sequencing a Phlebotomus duboscqi salivary gland cDNA library...
  47. ncbi A(2A) receptor dependent and A(2A) receptor independent effects of extracellular adenosine on murine thymocytes in conditions of adenosine deaminase deficiency
    S Apasov
    Biochemistry and Immunopharmacology Section, Laboratory of Immunology, NIAID, National Institutes of Health, Bethesda, MD 20982 1892, USA
    Blood 95:3859-67. 2000
    b>Adenosine deaminase (ADA) deficiency causes severe combined immunodeficiency (SCID) and is accompanied by T-cell depletion and accumulation of both intracellular and extracellular adenosine (extAdo) and deoxyadenosine...
  48. ncbi Activities of adenosine deaminase, 5'-nucleotidase, guanase, and cytidine deaminase enzymes in cancerous and non-cancerous human breast tissues
    O Canbolat
    Biochemistry Department, Ankara University, Ankara University, Turkey
    Breast Cancer Res Treat 37:189-93. 1996
    ..We found higher Adenosine Deaminase (ADA) and 5'-Nucleotidase (5'NT) and lower Guanase (GUA) activities in the cancerous tissues compared with ..
  49. ncbi Mechanisms of apoptosis in developing thymocytes as revealed by adenosine deaminase-deficient fetal thymic organ cultures
    Linda F Thompson
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, 825 NE, 13th Street, Oklahoma City, OK 73104, USA
    Biochem Pharmacol 66:1595-9. 2003
    b>Adenosine deaminase (ADA) catalyzes the conversion of adenosine and deoxyadenosine to inosine and deoxyinosine, respectively...
  50. ncbi A 9-yr evaluation of carrier erythrocyte encapsulated adenosine deaminase (ADA) therapy in a patient with adult-type ADA deficiency
    Bridget E Bax
    Child Health, Division of Clinical Developmental Sciences, St George s, University of London, London, UK
    Eur J Haematol 79:338-48. 2007
    b>Adenosine deaminase (ADA) deficiency is an inherited disorder which leads to elevated cellular levels of deoxyadenosine triphosphate (dATP) and systemic accumulation of its precursor, 2-deoxyadenosine...
  51. ncbi The salivary adenosine deaminase activity of the mosquitoes Culex quinquefasciatus and Aedes aegypti
    J M Ribeiro
    Medical Entomology Section, Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, 4 Center Drive, Room 4 126, Bethesda, MD 20892 0425, USA
    J Exp Biol 204:2001-10. 2001
    A cDNA coding for a protein with significant similarity to adenosine deaminase (ADA) was found while randomly sequencing a cDNA library constructed from salivary gland extracts of adult female Culex quinquefasciatus...
  52. ncbi Adenosine deaminase and tuberculous pericarditis--a systematic review with meta-analysis
    Felipe Francisco Tuon
    Infectious and Parasitic Diseases Clinic, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Avenida Dr Enéas de Carvalho Aguiar 255, 4 Andar Sala 4028 ICHC, Cerqueira Cesar, CEP Number 05403 010 São Paulo, Brazil
    Acta Trop 99:67-74. 2006
    b>Adenosine deaminase (ADA) activity in pericardial fluid is a valuable aid in the diagnosis of tuberculous pericarditis (TP), but there is no systematic review performed to evaluate the benefits of ADA activity as an adjunctive test for ..
  53. ncbi [Adenosine deaminase activity in tuberculous and malignant pleural effusions]
    Aleksandra Safianowska
    Katedra i Klinika Chorob Wewnetrznych, Pneumonologii i Alergologii AM w Warszawie
    Pneumonol Alergol Pol 74:5-9. 2006
    Measurement of pleural adenosine deaminase activity (ADA) is a useful diagnostic tool for tuberculous pleurisy, but false-positive findings from non-tuberculous effusions have been reported...
  54. ncbi Relevance of adenosine deaminase and lysozyme measurements in the diagnosis of tuberculous pericarditis
    C Aggeli
    Cardiology Department, University of Athens, Hippokration Hospital, Athens, Greece
    Cardiology 94:81-5. 2000
    To assess the value of pericardial fluid adenosine deaminase (ADA) and pericardial lysozyme (Lys) as tools in diagnosing tuberculous pericarditis.
  55. ncbi Cerebrospinal fluid adenosine deaminase activity for the diagnosis of tuberculous meningitis in adults
    Verajit Chotmongkol
    Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Southeast Asian J Trop Med Public Health 37:948-52. 2006
    We studied adenosine deaminase (ADA) activity in cerebrospinal fluid (CSF) of 16 cases of tuberculous meningitis, 4 cases of cryptococcal meningitis, 5 cases of bacterial meningitis, 12 cases of eosinophilic meningitis, 26 cases of ..
  56. ncbi Effect of adenosine kinase, adenosine deaminase and transport inhibitors on striatal dopamine and stereotypy after methamphetamine administration
    K Gołembiowska
    Department of Pharmacology, Institute of Pharmacology, Smetna 12, 31 343, Krakow, Poland
    Neuropharmacology 39:2124-32. 2000
    The effect of adenosine kinase (AKA), adenosine deaminase (ADA) and transport inhibitors on the release of dopamine (DA) induced by methamphetamine (MTH) in rat striatum was assessed using in vivo microdialysis in freely moving rats...
  57. doi Antithetical effects of corticosterone and dibutyryl cAMP on adenosine deaminase in the gastrointestinal tract of chicken during postnatal development
    Piyali Bhattacharjee
    Department of Biochemistry, North Eastern Hill University, Shillong 793022, Meghalaya, India
    Mol Cell Biochem 327:79-86. 2009
    b>Adenosine deaminase (ADA; EC 3.5.4.4) is a purine catabolic enzyme causing hydrolytic deamination of adenosine and 2'-deoxyadenosine to inosine and 2'-deoxyinosine...
  58. ncbi Adenosine deaminase activity and its isoenzymes in the sputum of patients with pulmonary tuberculosis
    K Dimakou
    Sixth Department of Respiratory Medicine, Sotiria Chest Hospital, Athens, Greece
    Int J Tuberc Lung Dis 13:744-8. 2009
    b>Adenosine deaminase (ADA) has been widely used for the diagnosis of tuberculous pleural effusion. Two isoenzymes have been described, ADA(1) and ADA(2).
  59. doi New insights into the pathogenesis of adenosine deaminase-severe combined immunodeficiency and progress in gene therapy
    Aisha V Sauer
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Italy
    Curr Opin Allergy Clin Immunol 9:496-502. 2009
    b>Adenosine deaminase (ADA)- deficient severe combined immunodeficiency (SCID) is a complex metabolic and immunological disorder, characterized by a severe immunodeficiency due to the accumulation of purine metabolites in plasma and cells...
  60. ncbi Serum adenosine deaminase enzyme and plasma platelet factor 4 activities in active pulmonary tuberculosis, HIV-seropositive subjects and cancer patients
    Gulnur Tarhan
    Refik Saydam Hygiene Center, Tuberculosis Reference and Research Laboratory, Ankara, Turkey
    J Infect 52:264-8. 2006
    The aim of this study was to determine the serum adenosine deaminase (ADA) and plasma platelet factor (PF-4) activities in patients with active pulmonary tuberculosis, HIV seropositive subjects, cancer patients (acute and chronic type ..
  61. ncbi Adenosine deaminase, nitric oxide, superoxide dismutase, and xanthine oxidase in patients with major depression: impact of antidepressant treatment
    Hasan Herken
    Department of Psychiatry, School of Medicine, Gaziantep University, Gaziantep, Turkey
    Arch Med Res 38:247-52. 2007
    ..In this study, we aimed to investigate whether NO, xanthine oxidase (XO), superoxide dismutase (SOD), and adenosine deaminase (ADA) levels are associated with major depression (MD) and to evaluate the impact of antidepressant ..
  62. ncbi Serum adenosine deaminase levels in pancreatic diseases
    Mehmet Ibis
    Department of Gastroenterology, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey
    Pancreatology 7:526-30. 2007
    b>Adenosine deaminase (ADA) is found in most tissues including the pancreas. Its role in inflammation and malignancy has been studied experimentally. To date, serum ADA levels in pancreatic diseases have not been studied before.
  63. ncbi Increased pleural fluid adenosine deaminase levels in patients with malignant pleural effusions: a potential predictor of talc pleurodesis outcome
    Huseyin Yildirim
    Department of Chest Diseases, Medical Faculty, Osmangazi University, Meselik, 26480, Eskisehir, Turkey
    Lung 185:349-54. 2007
    ..The objective of this study was to investigate the relationship between pleural fluid adenosine deaminase (Pf-ADA) levels and talc pleurodesis outcomes, and to compare Pf-ADA levels to various other biochemical ..
  64. doi Gene therapy for immunodeficiency due to adenosine deaminase deficiency
    Alessandro Aiuti
    San Raffaele Telethon Institute for Gene Therapy, Milan, Italy
    N Engl J Med 360:447-58. 2009
    We investigated the long-term outcome of gene therapy for severe combined immunodeficiency (SCID) due to the lack of adenosine deaminase (ADA), a fatal disorder of purine metabolism and immunodeficiency.
  65. ncbi Effect of propylthiouracil on adenosine deaminase activity and thyroid function in patients with psoriasis
    K Kose
    Department of Biochemistry, Faculty of Medicine, Erciyes University, 38039 Kayseri, Turkey
    Br J Dermatol 144:1121-6. 2001
    T-cell activation has been implicated in the pathogenesis of psoriasis; adenosine deaminase (ADA) activity has been considered as a marker of T-cell activation...
  66. ncbi Adenosine deaminase inhibition enhances the inotropic response mediated by A1 adenosine receptor in hyperthyroid guinea pig atrium
    Adam Kemeny-Beke
    Department of Ophthalmology, University of Debrecen, PO Box 30, H 4012 Debrecen, Hungary
    Pharmacol Res 56:124-31. 2007
    The aim of the present study was to test the hypothesis that inhibition of adenosine deaminase (ADA) enhances the efficiency of signal-transduction of myocardial A1 adenosine receptors in hyperthyroidism...
  67. ncbi Characterization of Adenosine deaminase (ADA) in hemolymph of Biomphalaria glabrata
    M R Vale
    Laboratorio de Bioquimica, Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceara, Rua Cel Nunes de Melo, 1127, CEP 60430 270, Rodolfo Teofilo, Fortaleza, Ceara, Brazil
    Braz J Biol 65:371-6. 2005
    Adenosine is an important signaling molecule for many cellular events. Adenosine deaminase (ADA) is a key enzyme for the control of extra- and intra-cellular levels of adenosine. Activity of ADA was detected in hemolymph of B...
  68. pmc Adenosine kinase inhibition promotes survival of fetal adenosine deaminase-deficient thymocytes by blocking dATP accumulation
    C Justin Van De Wiele
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    J Clin Invest 110:395-402. 2002
    Thymocyte development past the CD4(-)CD8(-) stage is markedly inhibited in adenosine deaminase-deficient (ADA-deficient) murine fetal thymic organ cultures (FTOCs) due to the accumulation of ADA substrates derived from thymocytes failing ..
  69. ncbi The use of adenosine deaminase and interferon-gamma as diagnostic tools for tuberculous pericarditis
    Lesley J Burgess
    Department of Cardiology, Tygerberg Hospital and University of Stellenbosch, South Africa
    Chest 122:900-5. 2002
    ..periods, and this has led to more emphasis being placed on biochemical tests such as the pericardial adenosine deaminase (ADA) test. However, controversy exists as to its diagnostic utility...
  70. pmc Further differentiation of murine double-positive thymocytes is inhibited in adenosine deaminase-deficient murine fetal thymic organ culture
    C Justin Van De Wiele
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, 825 Northeast 13th Street, Oklahoma City, OK 73104, USA
    J Immunol 176:5925-33. 2006
    Murine fetal thymic organ culture (FTOC) was used to investigate the mechanism by which a lack of adenosine deaminase (ADA) leads to a failure of T cell production in the thymus...
  71. ncbi Function of murine adenosine deaminase in the gastrointestinal tract
    P A Xu
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biochem Biophys Res Commun 269:749-57. 2000
    b>Adenosine deaminase (ADA) deficiency in humans leads to a combined immunodeficiency characterized by severe T and B cell lymphopenia. ADA-deficient humans also display defective development of gut-associated lymphoid tissues (GALT)...
  72. ncbi Impaired germinal center maturation in adenosine deaminase deficiency
    Melissa B Aldrich
    Department of Biochemistry and Molecular Biology, University of Texas Medical School, Houston, TX 77030, USA
    J Immunol 171:5562-70. 2003
    Mice deficient in the enzyme adenosine deaminase (ADA) have small lymphoid organs that contain reduced numbers of peripheral lymphocytes, and they are immunodeficient...
  73. ncbi Diagnostic utility of adenosine deaminase (ADA) activity in pleural fluid and serum of tuberculous and non-tuberculous respiratory disease patients
    Madhab Lamsal
    Department of Biochemistry, B P Koirala Institute of Health Sciences, Dharan, Nepal
    Southeast Asian J Trop Med Public Health 38:363-9. 2007
    b>Adenosine deaminase activity (ADA) was assayed in pleural fluid and serum of 42 subjects with pleural effusion. Twenty-nine of them had TB pleural effusion and the remaining 13 had pleural effusion due to non-TB respiratory diseases...
  74. ncbi Ontogeny of adenosine deaminase in the mouse decidua and placenta: immunolocalization and embryo transfer studies
    T B Knudsen
    Department of Anatomy, East Tennessee State University, James H Quillen College of Medicine, Johnson City 37614
    Biol Reprod 44:171-84. 1991
    This study has determined the cellular site of adenosine deaminase (ADA) expression in the mouse during development from Days 5 through 13 (day vaginal plug was found = Day 0) of gestation...
  75. ncbi Specific binding of adenosine deaminase but not HIV-1 transactivator protein Tat to human CD26
    J Blanco
    Unité de Virologie et d Immunologie Cellulaire, UA CNRS 1157, Institut Pasteur, Paris Cedex, France
    Exp Cell Res 225:102-11. 1996
    b>Adenosine deaminase (ADA) and the HIV-1 transactivator protein Tat have been reported to bind to human CD26, also known as dipeptidyl peptidase IV (DPP IV)...
  76. ncbi Regulation of adenosine concentration and cytoprotective effects of novel reversible adenosine deaminase inhibitors
    J Barankiewicz
    Cypros Pharmaceutical Corporation, Carlsbad, California 92008, USA
    J Pharmacol Exp Ther 283:1230-8. 1997
    ..actions of several novel erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) analogs to identify new reversible adenosine deaminase (ADA) inhibitors with potential clinical utility...
  77. ncbi In vivo kinetics of transduced cells in peripheral T cell-directed gene therapy: role of CD8+ cells in improved immunological function in an adenosine deaminase (ADA)-SCID patient
    N Kawamura
    Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan
    J Immunol 163:2256-61. 1999
    We previously reported successful peripheral T cell-directed gene therapy in a boy with adenosine deaminase (ADA)-SCID...
  78. ncbi A prospective study of sensitivity and specificity of adenosine deaminase estimation in the diagnosis of tuberculosis pleural effusion
    S K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi
    Indian J Chest Dis Allied Sci 43:149-55. 2001
    We prospectively evaluated the usefulness of adenosine deaminase [ADA] estimation in the diagnosis of tuberculosis [TB] pleural effusion. Seventy five subjects with pleural effusion were studied...
  79. pmc Adenosine deaminase activity is a sensitive marker for the diagnosis of tuberculous pleuritis in patients with very low CD4 counts
    Kamaldeen Baba
    Institute of Medicine, University of Bergen, Bergen, Norway
    PLoS ONE 3:e2788. 2008
    b>Adenosine Deaminase Activity (ADA) is a commonly used marker for the diagnosis of tuberculous pleural effusion...
  80. doi Concurrent measurement of adenosine deaminase and dipeptidyl peptidase IV activity in the diagnosis of tuberculous pleural effusion
    Elif Kupeli
    Department of Chest Diseases, Ankara University School of Medicine, 06100 Cebeci, Ankara, Turkey
    Diagn Microbiol Infect Dis 65:365-71. 2009
    Measurement of pleural fluid adenosine deaminase (ADA) levels aids diagnosing tuberculous pleural effusion (TPE). Dipeptidyl peptidase IV (DPP) enzyme is closely related to ADA...
  81. ncbi Enhanced oral bioavailability of 2'- beta-fluoro-2',3'-dideoxyadenosine (F-ddA) through local inhibition of intestinal adenosine deaminase
    R T DeGraw
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington 40536, USA
    Pharm Res 18:1270-6. 2001
    ..2-Beta-fluoro-2',3'-dideoxyadenosine (F-ddA) is an adenosine deaminase (ADA) activated prodrug of 2-beta-fluoro-2',3'-dideoxyinosine (F-ddI) with enhanced delivery to the central ..
  82. ncbi Serum adenosine deaminase activity in women with hyperemesis gravidarum
    Yoshio Yoneyama
    Department of Obstetrics and Gynecology, Nippon Medical School, 1 1 5, Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Clin Chim Acta 324:141-5. 2002
    Serum adenosine deaminase (ADA) activity increases in diseases where cellular immunity is stimulated. Since hyperemesis gravidarum is characterized by enhanced cell-mediated immunity, serum ADA activity may be altered...
  83. ncbi Correlation of serum levels of adenosine deaminase activity and its isoenzymes with disease activity in rheumatoid arthritis
    R A Sari
    Department of Immunology Rheumatology, Ataturk University, Medical School, Erzurum, Turkey
    Clin Exp Rheumatol 21:87-90. 2003
    b>Adenosine deaminase (ADA) is involved in purine metabolism and plays a significant role in the mechanisms of the immune system...
  84. ncbi Serum adenosine deaminase levels in reactional and non-reactional leprosy
    P K Nigam
    Department of Dermatology, Pt J N M Medical College, Raipur 492 001, India
    Indian J Dermatol Venereol Leprol 71:20-2. 2005
    Altered serum adenosine deaminase (ADA) levels have been recorded in various diseases involving lymphocytes and/or lymphoreticular system including leprosy...
  85. ncbi Does adenosine deaminase play a key role in coronary artery disease
    Ribo Tang
    Department of Cardiology, Beijing Anzhen Hospital, Capital University of Medical Sciences, Chaoyang District, Beijing 100029, China
    Med Hypotheses 67:371-4. 2006
    b>Adenosine deaminase (ADA) is an enzyme which catalyzes adenosine to inosine. Patients who inherently lack the enzyme have defects in both humoral and cellular immunity...
  86. ncbi Effects of adenosine deaminase and A1 receptor deficiency in normoxic and ischaemic mouse hearts
    Laura Willems
    Heart Foundation Research Center, Griffith University, Southport, QLD 4217, Australia
    Cardiovasc Res 71:79-87. 2006
    b>Adenosine deaminase (ADA) may be multifunctional, regulating adenosine levels and adenosine receptor (AR) agonism, and potentially modifying AR functionality...
  87. ncbi Diagnostic accuracy of ascitic fluid IFN-gamma and adenosine deaminase assays in the diagnosis of tuberculous ascites
    S K Sharma
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    J Interferon Cytokine Res 26:484-8. 2006
    ..evaluated the diagnostic accuracy and cost-effectiveness of ascitic fluid interferon-gamma (IFN-gamma) and adenosine deaminase (ADA) assays in the diagnosis of tuberculous ascites...
  88. ncbi Adenosine deaminase activity in cats infected with feline immunodeficiency virus
    Careen Hankanga
    Department of Clinical Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University
    J Vet Med Sci 69:881-5. 2007
    b>Adenosine deaminase (ADA), an enzyme involved in purine metabolism, has been shown to be of clinical importance in several diseases in humans...
  89. doi Serum adenosine deaminase levels in diagnosis of acute appendicitis
    Z A Oztürk
    Department of Internal Medicine, Ankara Education and Research Hospital, Ankara, Turkey
    Emerg Med J 25:583-5. 2008
    b>Adenosine deaminase (ADA) is found in most tissues including lymphoid cells and lymph nodes. It is a marker of T lymphocyte activation. The role of type 1 and type 2 T helper cells in appendicitis has been investigated experimentally...
  90. ncbi [Critically appraised article: Diagnostic accuracy of adenosine deaminase in tuberculous pleurisy: A metaanalyses]
    Cristian Herrera R
    Unidad de Medicina Basada en Evidencia
    Rev Med Chil 137:308-11. 2009
    ..Many studies have investigated the usefulness of adenosine deaminase (ADA) in pleural fluid for the early diagnosis of tuberculous pleuresy...
  91. pmc Localization of a bidirectional DNA replication origin in the native locus and in episomally amplified murine adenosine deaminase loci
    S M Carroll
    Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037
    Mol Cell Biol 13:2971-81. 1993
    ..The 4,000 extrachromosomal copies of the mouse adenosine deaminase (ADA) amplicon in B-1/50 cells initiate their replication remarkably synchronously in early S phase and at ..
  92. ncbi Regulation of adenosine receptor engagement by ecto-adenosine deaminase
    Tomoko Hashikawa
    Oklahoma Medical Research Foundation, Immunobiology and Cancer Research Program, Oklahoma City, Oklahoma, USA
    FASEB J 18:131-3. 2004
    b>Adenosine deaminase (ADA) can localize to the cell surface through its interaction with CD26...
  93. ncbi The diagnostic utility of adenosine deaminase isoenzymes in tuberculous pleural effusions
    A E Zemlin
    Division of Chemical Pathology, National Health Laboratory Service, Tygerberg Hospital, Stellenbosch University, Parow, Tygerberg, South Africa
    Int J Tuberc Lung Dis 13:214-20. 2009
    Pleural adenosine deaminase (ADA) levels have been found to be useful in diagnosing tuberculous pleuritis...
  94. doi Syzygium cumini inhibits adenosine deaminase activity and reduces glucose levels in hyperglycemic patients
    A Bopp
    Departamento de Analises Clinicas e Toxicologicas, Centro de Ciencias da Saude, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil
    Fundam Clin Pharmacol 23:501-7. 2009
    ..Leaves, fruits, and barks of S. cumini have been used for their hypoglycemic activity. Adenosine deaminase (ADA) is an important enzyme that plays a relevant role in purine and DNA metabolism, immune responses, and ..
  95. doi The different extent of B and T cell immune reconstitution after hematopoietic stem cell transplantation and enzyme replacement therapies in SCID patients with adenosine deaminase deficiency
    Federico Serana
    Department of Biomedical Science and Biotechnology, University of Brescia, Italy
    J Immunol 185:7713-22. 2010
    The lack of adenosine deaminase (ADA) leads to the accumulation of toxic metabolites, resulting in SCID. If the disease is left untreated, it is likely to have a fatal outcome in early infancy...
  96. ncbi Retroviral transfer of a chimeric multidrug resistance-adenosine deaminase gene
    U A Germann
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    FASEB J 4:1501-7. 1990
    A fusion between a selectable multidrug resistance (MDR1) cDNA and an adenosine deaminase (ADA) cDNA concomitantly confers multidrug resistance and ADA activity on transfected cells...
  97. ncbi [A case of tuberculous peritonitis diagnosed by ultrasonography-guide peritoneal biopsy]
    S Mizunoe
    Second Department of Internal Medicine, Oita Medical University
    Kansenshogaku Zasshi 74:589-93. 2000
    ..Diagnosis of tuberculous peritonitis has often been made by laparotomy or laparoscopy. In a case of this kind, percutaneous peritoneal biopsy guided by ultrasonography is safe and useful...
  98. pmc The black and white of dental education in the United States: enrollment and graduation trends
    R S Brown
    Department of Oral and Maxillofacial Pathology and Oral Diagnosis and Radiology, Howard University College of Dentistry, Washington, DC 20059, USA
    J Natl Med Assoc 92:536-43. 2000
    ..4. Greater support for minority dental education institutions. 5. Student loan forgiveness programs, which aid recruitment of minority faculty and dental students who either teach or serve minority communities...
  99. ncbi High-performance liquid chromatographic peak identification of 2,4-dinitrophenylhydrazine derivatives of lipid peroxidation aldehydes by photodiode array detection
    G A Cordis
    Department of Surgery, University of Connecticut School of Medicine, Farmington 06030-1110, USA
    J Chromatogr A 798:117-23. 1998
    ..This technique could accurately measure pmol amounts of MDA-DNPH indicating the usefulness of photodiode array detection method for estimating small changes in the oxidative stress...
  100. pmc Preferential accessibility of the yeast his3 promoter is determined by a general property of the DNA sequence, not by specific elements
    X Mai
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 20:6668-76. 2000
    ....
  101. pmc Expression of the E.coli ada gene in S.cerevisiae provides cellular resistance to N-methyl-N'-nitro-N-nitrosoguanidine in rad6 but not in rad52 mutants
    J Brozmanova
    Department of Molecular Genetics, Cancer Research Institute, Slovak Academy of Sciences, Bratislava
    Nucleic Acids Res 22:5717-22. 1994
    ..coli Ada protein in a RAD1- and RAD6-independent manner, the RAD52 gene product may be essential for the complete functioning of the Ada ATase. This is the first suggestion of a possible cofactor requirement for ATase...

Research Grants65

  1. Novel SCID rat models for human cell transplantation studies
    Joseph C Ruiz; Fiscal Year: 2010
    ..the use of a novel rat strain carrying a transposon-mediated knockout (KO) insertional mutation within the adenosine deaminase (Ada) locus in the inbred Fischer line...
  2. Adenosine Deaminase, Adenosine Signaling and Disease
    RODNEY KELLEMS; Fiscal Year: 2006
    b>Adenosine deaminase (ADA) deficiency was the first of the human immunodeficiencies for which the underlying biochemical defect was discovered...
  3. Purine Pathways and Inhibitor Design in Plasmodium
    Vern L Schramm; Fiscal Year: 2012
    ..falciparum purine nucleoside phosphorylase (PNP) and adenosine deaminase (ADA) have been solved and used to design transition state analogue inhibitors to match a their transition ..
  4. Donald B Kohn; Fiscal Year: 2016
    ..b>Adenosine deaminase (ADA)-deficient severe combined immune deficiency (SCID) has been treated using ?-retroviral (?-RV)-..
  5. Adenosine Signaling, Priapism and Sickle Cell Disease
    Yang Xia; Fiscal Year: 2012
    ..Recently my laboratory unexpectedly found that male adenosine deaminase (ADA)-deficient mice display features of priapism seen in humans, including spontaneous prolonged penile ..
  6. Gene Therapy for Purine Nucleoside Phosphorylase Deficiency (PNP)
    Kevin Baker; Fiscal Year: 2007
    ..also using retroviral transduction of marrow cells, but in this case for introduction of the gene encoding adenosine deaminase (ADA) for treatment of SCID associated with deficiency of ADA...
  7. TRANSLATIONAL CONTROL OF ADENOSINE DEAMINASE
    Elaine Chottiner; Fiscal Year: 1990
    Elevated erythrocyte adenosine deaminase (ADA) activity has been reported in association with hereditary hemolytic anemia (Valentine et al., Science 195:783-5, 1977)...
  8. ACTIVATION OF IMMUNOCOMPETENT LYMPHOCYTES
    Rochelle Hirschhorn; Fiscal Year: 1999
    Mutations at the adenosine deaminase (ADA) locus which diminish enzyme activity result in three major phenotypes...
  9. IMMUNODEFICIENCY AND ADA DEFICIENCY--MOLECULAR ANALYSIS
    MARY MARKERT; Fiscal Year: 1990
    The goal of this proposal is to elucidate the molecular bases of immunodeficiency in patients with adenosine deaminase (ADA) deficient severe combined immunodeficiency (SCID)...
  10. MOLECULAR REGULATION OF ADENOSINE IN RELATION TO SLEEP
    Miroslaw Mackiewicz; Fiscal Year: 2000
    ..These enzymes are adenosine deaminase (ADA), adenosine kinase (AK), and 5'-nucleotidase (5N)...
  11. ADENOSINE DEAMINASE--TARGET IN MOLECULAR TERATOGENESIS
    Thomas Knudsen; Fiscal Year: 1993
    The purpose of this project is to test the hypothesis that adenosine deaminase (ADA), a key enzyme in purine metabolism plays an essential role in early postimplantation development...
  12. Therapeutic management of SIRS with pentostatin
    WILLIAM LAW; Fiscal Year: 2002
    ..systemic inflammatory response syndromes (SIRS), amplifying endogenous adenosine action by inhibiting adenosine deaminase (ADA) with 2-deoxycoformycin (pentostatin) reduces proinflammatory cytokine responses, limits tissue ..
  13. ADENOSINE ANALOGS AS CANCER CHEMOTHERAPEUTIC AGENTS
    Robert Parks; Fiscal Year: 1992
    ..The studies are in three interrelated areas. 1. Inhibitors of adenosine deaminase (ADA) as chemotherapeutic agents...
  14. OVERPRODUCTION OF ADENOSINE DEAMINASE IN ERYTHROCYTES
    Beverly Mitchell; Fiscal Year: 1993
    b>Adenosine deaminase (ADA) is an enzyme of the purine catabolic pathway which is normally expressed in a tissue-specific manner...
  15. GENE THERAPY FOR SEVERE COMBINED IMMUNE DEFICIENCIES
    Kenneth Weinberg; Fiscal Year: 2000
    ..forms of SCID are due to mutations in the genes for the common gc cytokine receptor chain (X-linked SCID), adenosine deaminase (ADA), the JAK3 tyrosine kinase, the ZAP-70 tyrosine kinase, and the CIITA and RF-X proteins required for ..
  16. REGULATION OF ADENOSINE DEAMINASE GENE EXPRESSION
    RODNEY KELLEMS; Fiscal Year: 1991
    b>Adenosine deaminase (ADA) is an enzyme of purine metabolism that displays a fascinating pattern of tissue specific distribution and developmental regulation...
  17. Transgenic Mouse Model for Adenosine-induced Asthma
    Tehsheng Chan; Fiscal Year: 2003
    b>Adenosine deaminase (ADA) is a purine salvage enzyme that regulates the levels of adenosine and deoxyadenosine in mammalian tissues. Genetic deficiency of this enzyme is a cause of hereditary severe combined immune deficiency syndrome...
  18. CHILDREN'S CANCER STUDY GROUP A
    Samuel Gross; Fiscal Year: 1980
    ..Included in small group studies are those utilizing data on experiments in nature, i.e., adenosine deaminase (ADA) deficiency; anti-cancer effects of interferon; anti-tumor antibodies (common ALL, neuroblastoma); ..
  19. ADA DEFICIENT MICE--TESTING GROUND FOR NOVEL THERAPIES
    RODNEY KELLEMS; Fiscal Year: 2001
    ..b>Adenosine deaminase (ADA) deficiency is a genetic disease that has been the major testing ground for the therapeutic efficacy ..
  20. Kenneth Cusi; Fiscal Year: 2014
    ....
  21. Childhood Precursors for Adulthood Metabolic Syndrome
    Shumei S Sun; Fiscal Year: 2010
    ..abstract_text> ..
  22. Cognitive Behavioral Intervention in Diabetes Self-Mgt.
    Jillian Inouye; Fiscal Year: 2009
    ..abstract_text> ..
  23. MICHAEL ALLAN HOLINSTAT; Fiscal Year: 2016
    ..Finally, this study will give significant insight into alternative approaches such as 12-LOX inhibition in order to regulate platelet activity in the growing T2DM population. ..
  24. ADENOSINE DEAMINASE DEFICIENCY
    Linda Thompson; Fiscal Year: 2007
    Mutations in the gene for adenosine deaminase (ADA) cause severe combined immunodeficiency in humans. ADA-deficient patients exhibit a profound lymphopenia and are susceptible to a wide array of infectious agents...
  25. A LYMPHOBLAST MODEL FOR DISEASES OF PURINE METABOLISM
    Michael Hershfield; Fiscal Year: 2006
    ..and elucidate the biochemical and metabolic effects of inherited deficiency of the purine metabolic enzyme adenosine deaminase (ADA)...
  26. Type 2 Diabetes in Youth: Beta Cell Preservation
    Silva Arslanian; Fiscal Year: 2007
    ..A comprehensive approach to therapeutic interventions in children with type 2 diabetes mellitus will form the basis for prevention of adult morbidity and mortality starting early in childhood. ..
  27. Enhancing Group Identify May Improve Effectiveness of Diabetes Self-Management Ed
    JANET SUTTIE; Fiscal Year: 2010
    ..Second, we will evaluate if ways to foster group identity, such as naming each group receiving education or doing group competitions, increase health behaviors that result in better control of diabetes. ..
  28. Ofer Levy; Fiscal Year: 2016
    ..These studies will provide insight into neonatal immunity, establish novel platforms for studying immune ontogeny, assess Ado-refractory adjuvants, and inform neonatal vaccine development. ..
  29. CD-73 adenosine signaling in the central nervous system in disease and health
    Margaret S Bynoe; Fiscal Year: 2012
    ..Such therapies could be used to stop the progress of, or even possibly reverse the damage caused by MS. ..
  30. Incentives for Internet-based glucose testing in adolescent Type 1 diabetes
    Bethany R Raiff; Fiscal Year: 2011
    ..2001;Svoren et al., 2007), it is critically important to develop interventions that increase adherence of diabetes self-management skills in this population. ..
  31. Heather L Stuckey; Fiscal Year: 2014
    ..Determining the practices that contribute to A1c success could have a substantial public health impact on managing the diabetes epidemic and improve the treatment of diabetes that drive the field. ..
  32. LABOR MARKET EFFECTS OF DISABILITY DISCRIMINATION LAWS
    Kathleen Beegle; Fiscal Year: 1999
    ..Analysis will be extended to include the separate and perhaps complementary impacts of legislation that prohibits discrimination on the basis of age. ..
  33. Effect of Metformin on Vascular and Mitochondrial Function in Type 1 Diabetes
    Irene E Schauer; Fiscal Year: 2013
    ..The results of this study may validate a novel approach to T1D treatment that could significantly improve current management of cardiovascular disease risk in this high risk population. ..
  34. ADENOSINE SIGNALING AND LUNG INFLAMMATION
    Michael Blackburn; Fiscal Year: 2001
    ..To this end, we generated mice deficient in the purine catabolic enzyme adenosine deaminase (ADA)...
  35. Spinocerebellar ataxia 7 protein function.
    Patrick A Grant; Fiscal Year: 2010
    ..This, in turn, may suggest possible therapeutic treatments for this and other trinucleotide repeat diseases, such as Huntington's disease. ..
  36. Pre-existing Diabetes and Pregnancy
    Caitlin A Knox; Fiscal Year: 2013
    ..The evaluation of the safety of oral anti-diabetic agents will provide better-quality perinatal care, as well as contribute to future guidance on the treatment of pre-existing diabetes in pregnancy. ..
  37. Musculoskeletal Disorder in Dialysis Patients
    Sharon M Moe; Fiscal Year: 2010
    ..These studies, Dr. Moe, and the strong clinical research support at Indiana Unviersity provide an excellent training environment for the development of future investigators in patient oriented research. ..
  38. Space Renovation for New Research Center for the Neglected Diseases of Poverty
    John Williams; Fiscal Year: 2010
    ..S. and around the world-the neglected infections of poverty and the neglected tropical diseases. ..
  39. Anita Ghansah; Fiscal Year: 2016
    ....
  40. Biobehavioral Bases &Management of Type 2 Diabetes and Depression
    Neil Schneiderman; Fiscal Year: 2011
    ..abstract_text> ..
  41. The 50th Annual Meeting of the American Society of Pharmacognosy
    Bill J Baker; Fiscal Year: 2010
    ..It will advance NIH's human health goals through the exchange of scientific information and the fostering of collaborations in drug discovery. ..
  42. Development of an anti-bias caster system
    TODD HARGRODER; Fiscal Year: 2010
    ..Our goal it to determine the feasibility of a caster system which would reduce or eliminate these increased forces while propelling over sloped terrain and help increase community participation and quality of life. ..
  43. CAROLYN MARGARET PRIMUS; Fiscal Year: 2014
    ..The Quick-Set sealer will be used in a second canine study with decalcified histology. Laboratory testing will also be performed to increase the strength measurements of Quick-Set and develop paste-based formulas. ..
  44. Adoption Fidelity and Effectiveness of Alcohol SBIRT in Dental Practice
    James Alan Neff; Fiscal Year: 2010
    ..As a minimum of 60% of the U.S. population visits a dental office each year, the present project to test the effectiveness of SBIRT in dentist's offices can have enormous public health significance. ..
  45. Stem Cell Therapies for Primary Immune Deficiency
    GAY MIRIAM CROOKS; Fiscal Year: 2010
    ..Understanding the mechanisms that afford this developmental advantage may lead to improved approaches for immune disorders in older children and adults...
  46. Tamara S Hannon; Fiscal Year: 2015
    ..Phase two will begin in year 2 and continue through quarter 2 of year 4. Phase three involves statistical analysis and manuscript preparation. ..
  47. Matthew H Porteus; Fiscal Year: 2016
    ..Our goal with this proposal is to complete the IND-enabling experiments necessary to initiate a first-in-man gene therapy clinical trial using homologous recombination to cure SCID. ..
  48. Vince D Calhoun; Fiscal Year: 2016
    ..We include an extensive educational, mentoring, and faculty development program to carefully mentor and establish junior investigators as independently funded investigators, thus fulfilling the ultimate goals of the COBRE program. ..
  49. Domenico Accili; Fiscal Year: 2016
    ....
  50. SAN DIEGO LATINO RESEARCH CENTER OF EXCELLENCE PARTNERSHIP TO REDUCE CVD DISPARIT
    Gregory A Talavera; Fiscal Year: 2011
    ..The SYHC will provide the population of focus and the setting for disparities research and the clinicians with intimate knowledge of the Latino community. ..
  51. Functional phenotyping of leukocyte reprogramming in Type 1 diabetes
    Michael A Lynes; Fiscal Year: 2013
    ..At present, there are no systems available that offer the breadth of capabilities, the simplicity of use and limited sample size requirements as the proposed T cell analysis system using MHC-peptide arrays in the fight against T1D. ..
  52. DANIEL HOLLAND BESSESEN; Fiscal Year: 2016
    ..We therefore request continued support of the TPDEM at UCDSOM. ..
  53. A Next-Generation Split Hook Prehensor with Enhanced Grasp Functionality
    BRADLEY D VEATCH; Fiscal Year: 2010
    ..The device is designed to delight users, improving their quality of life by helping them become or remain productive members of society through renewed self-sufficiency, sense of purpose, and personal dignity. ..
  54. Nonvisual Foot Examination for People with Diabetes and Visual Impairment
    Ann S Williams; Fiscal Year: 2012
    ..The potential downstream impact is reduced costs of care for diabetes complications on the population level. For every 1% reduction in diabetic foot complications, costs would be reduced by $137 million. ..
  55. WEIBEL PALADE BODY FORMATION AND ROLE IN HEMOSTASIS
    DENISA WAGNER; Fiscal Year: 2007
    ..We will investigate how inhibition of a particular component[unreadable] of these vesicles could improve outcome in these major diseases. [unreadable]..
  56. ISEV Meeting (International Society of Extracellular Vesicles)
    Fred H Hochberg; Fiscal Year: 2013
    ..Four traveling fellowships will support these minorities. The Conference Center is ADA compliant. ..
  57. Latha P Palaniappan; Fiscal Year: 2016
    ..The goal of the Initiate and Maintai Physical Activity in Clinics (IMPACT) Diabetes Study is to translate the known benefits of supervised physical activity in a clinical setting. ..
  58. This SBIR project seeks to develop a low-cost home vision self-test system which
    Michael Bartlett; Fiscal Year: 2009
    ..This SBIR project seeks to develop a low-cost home vision self-test system which enables diabetes patients to identify significant vision changes and to get treatment when it can be most effective to prevent vision loss. ..
  59. BM12: Brief Motivational Interviewing to Reduce Child BMI
    KEN A RESNICOW; Fiscal Year: 2012
    ..The results of this study could impact training, policy, and reimbursement of obesity care in pediatric practice. ..
  60. Regulation of transcriptional initiation by the 19S proteasome subcomplex.
    Sukesh R Bhaumik; Fiscal Year: 2013
    ....
  61. A Low-Cost Upper-Extremity Prosthesis for Under-Served Populations
    BRADLEY VEATCH; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  62. Using Virtual Environments to Improve Health and Compliance in Diabetes
    GEOFFREY C contact WILLIAMS; Fiscal Year: 2010
    ....
  63. Inducing Tolerance to Enzyme Replacement Therapy for Pompe Disease
    ANNE SEARLS DEGROOT; Fiscal Year: 2013
    ..D. expert in Tregitope immunomodulation studies, Tim Messitt, Ph.D. molecular biologist and Federico Mingozzi Ph.D., AAV expert, who will co-develop the Tregitope-GAA AAV vector. ..
  64. Implementing Research Findings and Evidence-Based Interventions into Real-World D
    Heiko Spallek; Fiscal Year: 2012
    ..We anticipate that our solutions will be useful in leveraging solutions for the integration of EB guidelines in similar practice settings as well. ..
  65. Development of the PathLock biasing caster system Phase 2
    TODD HARGRODER; Fiscal Year: 2013
    ..Year 1 of this proposal will be to finalize the design and testing of the PathLock for TiLite TR wheelchairs, and Year 2 will be devoted to adapting the PathLock to other varieties and classifications of MWCs. ..