ACTH

Summary

Gene Symbol: ACTH
Description: proopiomelanocortin
Alias: ACTH, CLIP, LPH, MSH, NPP, POC, pro-opiomelanocortin, adrenocorticotropic hormone, adrenocorticotropin, alpha-MSH, alpha-melanocyte-stimulating hormone, beta-LPH, beta-MSH, beta-endorphin, beta-melanocyte-stimulating hormone, corticotropin-like intermediary peptide, corticotropin-lipotropin, gamma-LPH, gamma-MSH, lipotropin beta, lipotropin gamma, melanotropin alpha, melanotropin beta, melanotropin gamma, met-enkephalin, opiomelanocortin prepropeptide, pro-ACTH-endorphin, proopiomelanocortin preproprotein
Species: human

Top Publications

  1. ncbi Beta-endorphin, insulin, ACTH and cortisol plasma levels during oral glucose tolerance test in obesity after weight loss
    C Giovannini
    Neuroendocrinology, University of Rome La Sapienza, Italy
    Horm Metab Res 22:96-100. 1990
  2. ncbi Intrathecal administration of oxytocin induces analgesia in low back pain involving the endogenous opiate peptide system
    J Yang
    Department of Nuclear Medicine, Nan Fang Hospital, Guang Zhou, Guangdong, PR China
    Spine (Phila Pa 1976) 19:867-71. 1994
  3. ncbi Expression of three proopiomelanocortin subtype genes and mass spectrometric identification of POMC-derived peptides in pars distalis and pars intermedia of barfin flounder pituitary
    Akiyoshi Takahashi
    School of Fisheries Sciences, Kitasato University, Sanriku, Ofunato, Iwate 022 0101, Japan
    Gen Comp Endocrinol 145:280-6. 2006
  4. ncbi Polymorphisms in genes regulating the HPA axis associated with empirically delineated classes of unexplained chronic fatigue
    Alicia K Smith
    Centers for Disease Control and Prevention, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, 1600 Clifton Road, MSG41, Atlanta, GA 30333, USA
    Pharmacogenomics 7:387-94. 2006
  5. ncbi Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin
    Heike Munzberg
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Endocrinology 144:2121-31. 2003
  6. ncbi Cell surface expression of melanocortin-1 receptor on HaCaT keratinocytes and alpha-melanocortin stimulation do not affect the formation and repair of UVB-induced DNA photoproducts
    Geneviève Garcin
    UMR CNRS 5247 IBMM, Université Montpellier I Faculté de Pharmacie, 15 Av Charles Flahault BP 14 491, 34093, Montpellier Cedex 5, and Department of Dermatology, Groupe Hospitalo Universitaire Caremeau, Nimes, France
    Photochem Photobiol Sci 6:585-93. 2007
  7. pmc Technical details influence the diagnostic accuracy of the 1 microg ACTH stimulation test
    Matthew Wade
    Program in Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development Pharmacy Department, National Institutes of Health, Clinical Center, Bethesda, Maryland, USA
    Eur J Endocrinol 162:109-13. 2010
  8. ncbi The melanocortin-1 receptor is a key regulator of human cutaneous pigmentation
    Z Abdel-Malek
    University of Cincinnati, Ohio, 45267 592, USA
    Pigment Cell Res 13:156-62. 2000
  9. ncbi UV-induced expression of key component of the tanning process, the POMC and MC1R genes, is dependent on the p-38-activated upstream stimulating factor-1 (USF-1)
    Sébastien Corre
    CNRS UMR 6061 Laboratoire de Génétique et Développement, Faculte de Medecine, Universite de Rennes 1, 2 Avenue du Pr Leon Bernard, 35043 Rennes, France
    J Biol Chem 279:51226-33. 2004
  10. ncbi Alpha-melanocyte-stimulating hormone suppresses antigen-induced lymphocyte proliferation in humans independently of melanocortin 1 receptor gene status
    Ashley Cooper
    Dermatopharmacology Unit, University of Southampton, Southampton, United Kingdom
    J Immunol 175:4806-13. 2005

Research Grants

  1. REGULATION OF ANTERIOR PITUITARY FUNCTION BY POMC
    Sharon Wardlaw; Fiscal Year: 1990
  2. OPIOID REGULATION OF POMC IN THE HYPOTHALAMUS
    Sharon Wardlaw; Fiscal Year: 2000
  3. OPIOMELANOCORTIN PEPTIDES AND CARDIOVASCULAR REGULATION
    George Kunos; Fiscal Year: 1999
  4. REGULATION OF SECRETION OF POMC PEPTIDES IN BRAIN
    LEONARD KAPCALA; Fiscal Year: 1991
  5. Brain mast cells and Chronic Fatigue Syndrome
    Theoharis C Theoharides; Fiscal Year: 2013
  6. David E Fisher; Fiscal Year: 2015
  7. CHRISTINE MICHELE BURT SOLORZANO; Fiscal Year: 2016
  8. LATRICE DOREEN FAULKNER; Fiscal Year: 2015
  9. Cathepsin L in the Biosynthesis of Enkephalins and beta-Endorphin Opioid Peptides
    Steven J Bark; Fiscal Year: 2012
  10. MARTIN JEFFREY KELLY; Fiscal Year: 2016

Detail Information

Publications739 found, 100 shown here

  1. ncbi Beta-endorphin, insulin, ACTH and cortisol plasma levels during oral glucose tolerance test in obesity after weight loss
    C Giovannini
    Neuroendocrinology, University of Rome La Sapienza, Italy
    Horm Metab Res 22:96-100. 1990
    ..possible relationship between opioid peptides and glucose homeostasis in obesity we studied Beta-Endorphin (B-Ep), ACTH, cortisol and insulin plasma levels in response to an oral glucose tolerance test (OGTT) in 8 subjects after a ..
  2. ncbi Intrathecal administration of oxytocin induces analgesia in low back pain involving the endogenous opiate peptide system
    J Yang
    Department of Nuclear Medicine, Nan Fang Hospital, Guang Zhou, Guangdong, PR China
    Spine (Phila Pa 1976) 19:867-71. 1994
    ..CONCLUSIONS: These results suggest that oxytocin induces analgesia in low back pain involving the endogenous opiate peptide system and may be effective and safe in acute and chronic low back pain...
  3. ncbi Expression of three proopiomelanocortin subtype genes and mass spectrometric identification of POMC-derived peptides in pars distalis and pars intermedia of barfin flounder pituitary
    Akiyoshi Takahashi
    School of Fisheries Sciences, Kitasato University, Sanriku, Ofunato, Iwate 022 0101, Japan
    Gen Comp Endocrinol 145:280-6. 2006
    Proopiomelanocortin (POMC) is a common precursor of adrenocorticotropic hormone (ACTH), melanophore-stimulating hormone (MSH), and endorphin (END)...
  4. ncbi Polymorphisms in genes regulating the HPA axis associated with empirically delineated classes of unexplained chronic fatigue
    Alicia K Smith
    Centers for Disease Control and Prevention, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, 1600 Clifton Road, MSG41, Atlanta, GA 30333, USA
    Pharmacogenomics 7:387-94. 2006
    ..These data support the hypothesis that medically unexplained chronic fatigue is heterogeneous and presents preliminary evidence of the genetic mechanisms underlying some of the putative conditions...
  5. ncbi Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin
    Heike Munzberg
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Endocrinology 144:2121-31. 2003
    ..We speculate that STAT3 is critical for leptin-dependent effects on energy homeostasis that are mediated by the central melanocortin system...
  6. ncbi Cell surface expression of melanocortin-1 receptor on HaCaT keratinocytes and alpha-melanocortin stimulation do not affect the formation and repair of UVB-induced DNA photoproducts
    Geneviève Garcin
    UMR CNRS 5247 IBMM, Université Montpellier I Faculté de Pharmacie, 15 Av Charles Flahault BP 14 491, 34093, Montpellier Cedex 5, and Department of Dermatology, Groupe Hospitalo Universitaire Caremeau, Nimes, France
    Photochem Photobiol Sci 6:585-93. 2007
    ..of melanocortin-1 receptor (MC1R) expression in human skin and the alpha-melanocyte-stimulating hormone (alpha-MSH) may reduce UVB-induced DNA damage in normal human melanocytes...
  7. pmc Technical details influence the diagnostic accuracy of the 1 microg ACTH stimulation test
    Matthew Wade
    Program in Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development Pharmacy Department, National Institutes of Health, Clinical Center, Bethesda, Maryland, USA
    Eur J Endocrinol 162:109-13. 2010
    To examine the factors causing inadequate cortisol responses to the 1 microg ACTH stimulation test.
  8. ncbi The melanocortin-1 receptor is a key regulator of human cutaneous pigmentation
    Z Abdel-Malek
    University of Cincinnati, Ohio, 45267 592, USA
    Pigment Cell Res 13:156-62. 2000
    ..respond to the melanocortins, alpha-melanocyte stimulating hormone (alpha-MSH) and adrenocorticotrophic hormone (ACTH), with increased proliferation and eumelanogenesis had put an end to a long-standing controversy about the role of ..
  9. ncbi UV-induced expression of key component of the tanning process, the POMC and MC1R genes, is dependent on the p-38-activated upstream stimulating factor-1 (USF-1)
    Sébastien Corre
    CNRS UMR 6061 Laboratoire de Génétique et Développement, Faculte de Medecine, Universite de Rennes 1, 2 Avenue du Pr Leon Bernard, 35043 Rennes, France
    J Biol Chem 279:51226-33. 2004
    ..The results define USF-1 as a critical UV-responsive activator of genes implicated in protection from solar radiation...
  10. ncbi Alpha-melanocyte-stimulating hormone suppresses antigen-induced lymphocyte proliferation in humans independently of melanocortin 1 receptor gene status
    Ashley Cooper
    Dermatopharmacology Unit, University of Southampton, Southampton, United Kingdom
    J Immunol 175:4806-13. 2005
    ....
  11. pmc Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats
    Cindy K Funk
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 61:78-86. 2007
    ..Here, we used an animal model of ethanol dependence to test the effects of CRF(1) receptor antagonists on excessive ethanol self-administration in dependent rats...
  12. ncbi Antimicrobial effects of alpha-MSH peptides
    M Cutuli
    3rd Division of Internal Medicine, IRCCS Ospedale Maggiore, Milano, Italy
    J Leukoc Biol 67:233-9. 2000
    The presence of the ancient anti-inflammatory peptide alpha-melanocyte-stimulating hormone [alpha-MSH (1-13), SYSMEHFRWGKPV] in barrier organs such as gut and skin suggests a role in the nonspecific (innate) host defense...
  13. ncbi The opioid system in alcohol and drug dependence: family-based association study
    Xiaoling Xuei
    Indiana University School of Medicine, 1345 W 16th Street, Indianapolis, IN 46202, USA
    Am J Med Genet B Neuropsychiatr Genet 144:877-84. 2007
    ....
  14. doi In vitro antimicrobial activity of alpha-melanocyte stimulating hormone against major human pathogen Staphylococcus aureus
    - Madhuri
    School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, India
    Peptides 30:1627-35. 2009
    Alpha-melanocyte stimulating hormone (alpha-MSH) is an endogenous anti-inflammatory peptide reported to possess antimicrobial properties, however their role as antibacterial peptides is yet to be established...
  15. doi Promoter specific DNA methylation and gene expression of POMC in acutely underweight and recovered patients with anorexia nervosa
    Stefan Ehrlich
    Charite Universitatsmedizin Berlin, CVK, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Berlin, Germany
    J Psychiatr Res 44:827-33. 2010
    Proopiomelanocortin (POMC) and its derived peptides, in particular alpha-MSH, have been shown to play a crucial role in the regulation of hunger, satiety and energy homeostasis...
  16. ncbi Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
    H Krude
    Department of Pediatrics, Charite, Campus Virchow, Humboldt University Berlin, Germany
    Nat Genet 19:155-7. 1998
    ..of the precursor protein pre-pro-opiomelanocortin (POMC) generates the melanocortin peptides adrenocorticotrophin (ACTH), melanocyte-stimulating hormones (MSH) alpha, beta and gamma as well as the opioid-receptor ligand beta-endorphin...
  17. ncbi Clinical, genetic, and functional characterization of adrenocorticotropin receptor mutations using a novel receptor assay
    Christa E Flück
    Department of Pediatrics and Metabolic Research Unit, University of California, San Francisco, California 94143 0978, USA
    J Clin Endocrinol Metab 87:4318-23. 2002
    The ACTH receptor (MC2R) is expressed predominantly in the adrenal cortex, but is one of five G protein-coupled, seven-transmembrane melanocortin receptors (MCRs), all of which bind ACTH to some degree...
  18. ncbi Regulation of human epidermal melanocyte biology by beta-endorphin
    Sobia Kauser
    Department of Biomedical Sciences, University of Bradford, West Yorkshire, UK
    J Invest Dermatol 120:1073-80. 2003
    ..peptide cleaved from the precursor pro-hormone pro-opiomelanocortin, from which other peptides such as adrenocorticotropic hormone, beta-lipotropic hormone, and alpha-melanocyte-stimulating hormone are also derived...
  19. pmc The opioid peptides enkephalin and beta-endorphin in alcohol dependence
    Ildiko Racz
    Institute of Molecular Psychiatry, Life and Brain Center, University of Bonn, Bonn, Germany
    Biol Psychiatry 64:989-97. 2008
    ..Because stress is an important factor contributing to drug dependence and relapse, we have now studied ethanol preference in enkephalin- and beta-endorphin-deficient mice under baseline conditions and after stress exposure...
  20. pmc Pro-opiomelanocortin gene variation related to alcohol or drug dependence: evidence and replications across family- and population-based studies
    Huiping Zhang
    Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Biol Psychiatry 66:128-36. 2009
    ..The pro-opiomelanocortin gene (POMC) encodes several peptides important for endogenous opioidergic neurotransmission. We tested whether POMC genetic variation affects risk for substance dependence...
  21. doi Galanin and α-MSH autoantibodies in cerebrospinal fluid of patients with Alzheimer's disease
    Alfredo Costa
    National Institute of Neurology IRCCS C Mondino, University of Pavia, Italy
    J Neuroimmunol 240:114-20. 2011
    Neuropeptides galanin and α-melanocyte-stimulating hormone (α-MSH) are involved in the regulation of memory and appetite...
  22. pmc High-resolution chromosomal localization of human genes for amylase, proopiomelanocortin, somatostatin, and a DNA fragment (D3S1) by in situ hybridization
    B U Zabel
    Proc Natl Acad Sci U S A 80:6932-6. 1983
    ....
  23. ncbi Mutational analysis of the proopiomelanocortin gene in Caucasians with early onset obesity
    S M Echwald
    Steno Diabetes Center and Hagedorn Research Institute, Copenhagen, Denmark
    Int J Obes Relat Metab Disord 23:293-8. 1999
    ..In this study we have used polymerase chain reaction (PCR) and single strand conformation polymorphism (SSCP) analysis, to test whether variations in the human POMC gene are associated with human obesity...
  24. ncbi Linkage and association studies between the proopiomelanocortin (POMC) gene and obesity in caucasian families
    J Delplanque
    Institute of Biology CNRS 8090, Pasteur Institute of Lille, CHRU of Lille, Lille, France
    Diabetologia 43:1554-7. 2000
    ..A polyhormone peptide, POMC is expressed in brain, gut, placenta and pancreas. The POMC mutations are responsible for rare cases of early-onset obesity. Thus we examined the contribution of the POMC locus to obesity in French families...
  25. ncbi Polymorphisms in exon 3 of the proopiomelanocortin gene in relation to serum leptin, salivary cortisol, and obesity in Swedish men
    Roland Rosmond
    Department of Internal Medicine, Research Centre for Endocrinology and Metabolism, Goteborg University, Grona Straket 8, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    Metabolism 51:642-4. 2002
    ..This association might reflect variations in melanocortin expression and/or activity, because exon 3 contains, among others, the coding sequences for melanocortins...
  26. ncbi Prostaglandin production by melanocytic cells and the effect of alpha-melanocyte stimulating hormone
    Anna Nicolaou
    School of Pharmacy, University of Bradford, Bradford BD7 1DP, UK
    FEBS Lett 570:223-6. 2004
    ..The anti-inflammatory peptide, alpha-melanocyte stimulating hormone (alpha-MSH), reduced prostaglandin production in FM55 and HaCaT cells and reversed the effect of the pro-inflammatory cytokine ..
  27. ncbi Molecular screening of the proopiomelanocortin (POMC ) gene in Italian obese children: report of three new mutations
    E Miraglia del Giudice
    Department of Pediatrics, Second University of Naples, Via S Andrea delle Dame no 4, 80138 Napoli, Italy
    Int J Obes Relat Metab Disord 25:61-7. 2001
    ..Although linkage studies strongly suggest that proopiomelanocortin (POMC) alterations could play a role in the genetic predisposition to obesity, systematic POMC mutational analysis did not completely confirm this hypothesis...
  28. ncbi Aberrant production and regulation of proopiomelanocortin-derived peptides in ectopic Cushing's syndrome
    K A Roth
    Department of Pathology, Washington University School of Medicine, St. Louis, Missouri
    Horm Metab Res 20:225-9. 1988
    ..Immunohistochemistry and radioimmunoassays revealed the presence of immunoreactive ACTH, beta-endorphin and alpha-MSH in the tumor cells...
  29. ncbi C-terminal fragments of ACTH stimulate feeding in fasted rats
    K A Al-Barazanji
    Department of Vascular Biology, GlaxoSmithKline, New Frontiers Science Park, Harlow, Essex, UK
    Horm Metab Res 33:480-5. 2001
    Peptides derived from pro-opiomelanocortin, including alpha-MSH and ACTH, play important roles in the regulation of feeding...
  30. ncbi The effect of repetitive haemorrhage on plasma cortisol, beta-endorphin and N-terminal pro-opiomelanocortin in conscious sheep
    R Smith
    Faculty of Medicine, University of Newcastle, New South Wales, Australia
    Horm Metab Res 20:612-5. 1988
    ..stress, performed on four consecutive days in conscious adult sheep, on the plasma concentrations of cortisol and ACTH-related peptides to determine whether the pituitary-adrenal response was altered by stress repetition...
  31. ncbi POMC biosynthesis in the intermediate lobe of the spontaneously hypertensive rat
    R A Felder
    Department of Pathology, University of Virginia Medical Center, Charlottesville 22908
    Am J Hypertens 2:618-24. 1989
    ..Because POMC biosynthesis in IL increased with normalization of blood pressure in the SHR, the decreased POMC biosynthesis in SHR may be a consequence rather than a cause of the elevated blood pressure in SHR...
  32. ncbi Adrenal androgen secretion and dopaminergic activity in anorexia nervosa
    J Devesa
    , Dept. of Physiology, Faculty of Medicine, Santiago de Compostela, Spain
    Horm Metab Res 20:57-60. 1988
    ..The adrenal responses to ACTH and PRL response to dopaminergic receptor blockade were studied in seven patients with Anorexia Nervosa and seven ..
  33. ncbi Effects of bilateral olfactory bulbectomy on the anterior pituitary corticotropic cell activity in male rats
    A Marcilhac
    Neuroendocrinology Laboratory, INSERM U501, University of Medicine, Marseille, France
    Horm Metab Res 31:399-401. 1999
    ..This experiment examined the effects of OB on adrenocorticotropin (ACTH) and corticosterone release under basal and stress conditions and on proopiomelanocortin (POMC) gene ..
  34. ncbi Pituitary proopiomelanocortin-derived peptides and hypothalamus-pituitary-interrenal axis activity in gilthead sea bream (Sparus aurata) during prolonged crowding stress: differential regulation of adrenocorticotropin hormone and alpha-melanocyte-stimulat
    J Rotllant
    Department of Cell Biology and Physiology, Universitat Autonoma de Barcelona, Bellaterra, 08193, Spain
    Gen Comp Endocrinol 119:152-63. 2000
    Plasma levels of cortisol, growth hormone (GH), adrenocorticotropin hormone (ACTH), alpha-melanocyte-stimulating hormone (alpha-MSH), N-acetyl-beta-endorphin, in vitro ACTH-stimulated cortisol secretion, and in vitro corticotropin-..
  35. ncbi Melanocortins and cardiovascular regulation
    D H Versteeg
    Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Utrecht University, Netherlands
    Eur J Pharmacol 360:1-14. 1998
    ..gamma2-MSH, its des-Gly12 analog (= gamma1-MSH) and Lys-gamma2-MSH are 5-10 times more potent than adrenocorticotropic hormone-(4-10)(ACTH-(4-10)) to induce a pressor and tachycardiac effect following intravenous administration...
  36. ncbi Reduced abundance of aquaporins in rats with bilateral ischemia-induced acute renal failure: prevention by alpha-MSH
    T H Kwon
    Department of Cell Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus, Denmark
    Am J Physiol 277:F413-27. 1999
    ..whether reducing ischemia/reperfusion (I/R) injury by treatment with alpha-melanocyte stimulating hormone (alpha-MSH) affects the expression of AQPs and urine output...
  37. ncbi Some functional aspects of canine corticotrophs
    D J Middleton
    Faculty of Veterinary Medicine, Division of Comparative Endocrinology, State University, Utrecht, The Netherlands
    Horm Metab Res 19:632-5. 1987
    To examine the regulation and functional significance of canine pituitary pars intermedia corticotrophs, ACTH and cortisol responses to CRF were studied in healthy dogs before and after treatment with dexamethasone...
  38. ncbi Distribution of pro-opiomelanocortin and its peptide end products in the brain and hypophysis of the aquatic toad, Xenopus laevis
    R Tuinhof
    Nijmegen Institute for Neurosciences, Department of Cellular Animal Physiology, University of Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
    Cell Tissue Res 292:251-65. 1998
    ..hormone (alpha-MSH), gamma-MSH, acetylated and non-acetylated endorphins and adrenocorticotropic hormone (ACTH)...
  39. ncbi Structural analysis of the entire proopiomelanocortin gene of Xenopus laevis
    P M Deen
    Department of Animal Physiology, University of Nijmegen, The Netherlands
    Eur J Biochem 201:129-37. 1991
    ..proopiomelanocortin (POMC) is tissue-specifically processed to, among other peptides, alpha-melanotropin (alpha MSH)...
  40. doi Release of melanotroph- and corticotroph-type proopiomelanocortin derivatives into blood after administration of corticotropin-releasing hormone in patients with septic shock without adrenocortical insufficiency
    Reginald Matejec
    Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, Justus Liebig University of Giessen, Giessen, Germany
    Shock 31:553-60. 2009
    ..beta-END, and beta-lipotropin IRM) as well as melanotroph-type (alpha-melanocyte-stimulating hormone [alpha-MSH] and N-acetyl-beta-END [Nac-beta-END] IRM) proopiomelanocortin (POMC) derivatives in patients under septic shock ..
  41. ncbi Pituitary gland: neuropeptides, neurotransmitters and growth factors
    J I Koenig
    Neurology Service, Massachusetts General Hospital, Boston
    Toxicol Pathol 17:256-65. 1989
    ..The stimulatory influence of norepinephrine, serotonin, and acetylcholine on the secretion of corticotropin (ACTH) in rodents and man will be discussed, whereas GABA exerts an inhibitory effect on the secretion of ACTH in both ..
  42. ncbi Sauvagine and TRH differentially stimulate proopiomelanocortin biosynthesis in the Xenopus laevis intermediate pituitary
    C H Dotman
    Department of Cellular Animal Physiology, University of Nijmegen, The Netherlands
    Neuroendocrinology 66:106-13. 1997
    ..of the skin color to background light intensity is regulated by alpha-melanophore-stimulating hormone (alpha-MSH), a proopiomelanocortin (POMC)-derived peptide...
  43. ncbi Alpha-amidated peptides derived from pro-opiomelanocortin in human pituitary tumours
    M Fenger
    Department of Clinical Chemistry KK, University Hospital of Copenhagen, Denmark
    J Endocrinol 118:329-38. 1988
    ..7%; amidated gamma-MSH (gamma 1-MSH), 8.5% and the peptide linking gamma-MSH and ACTH in the precursor (hinge peptide or joining peptide) in its amidated form (HP-N), 17.1%...
  44. pmc Ethanol-induced increase of agouti-related protein (AgRP) immunoreactivity in the arcuate nucleus of the hypothalamus of C57BL/6J, but not 129/SvJ, inbred mice
    Inmaculada Cubero
    Department of Neurociencia y Ciencias de la Salud, University of Almeria, Almeria, Spain
    Alcohol Clin Exp Res 34:693-701. 2010
    ..exposure to an ethanol-containing diet causes significant reductions of alpha-melanocyte stimulating hormone (alpha-MSH) immunoreactivity in specific brain regions of Sprague-Dawley rats...
  45. ncbi Studies on the neuroendocrine role of serotonin
    Henrik Stig Jørgensen
    Department of Medical Physiology, University of Copenhagen, Denmark
    Dan Med Bull 54:266-88. 2007
    ..of hypothalamic hormones and in the secretion of the pituitary gland hormones prolactin (PRL), adrenocorticotropic hormone (ACTH), vasopressin (AVP) and oxytocin in basal and stress conditions...
  46. pmc Dopamine-regulated adrenocorticotropic hormone secretion in lactating rats: functional plasticity of melanotropes
    MARK OLAH
    Neuromorphological and Neuroendocrine Research Laboratory, Department of Human Morphology and Developmental Biology, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary
    Neuroendocrinology 90:391-401. 2009
    Pro-opiomelanocortin (POMC) is processed to adrenocorticotropic hormone (ACTH) and beta-lipotropin in corticotropes of the anterior lobe, and to alpha-melanocyte-stimulating hormone (alpha-MSH) and beta-endorphin in melanotropes of the ..
  47. ncbi Influence of paroxetine, branched-chain amino acids and tyrosine on neuroendocrine system responses and fatigue in humans
    H K Struder
    Institute of Sports Games, German Sport University, Koln
    Horm Metab Res 30:188-94. 1998
    ..Plasma prolactin (PRL), growth hormone, cortisol, adrenocorticotropic hormone, norepinephrine and epinephrine increased during all trials. Plasma PRL increments were higher in T IV...
  48. ncbi Differential effects of alpha-, beta- and gamma(2)-melanocyte-stimulating hormones on hypothalamic neuronal activation and feeding in the fasted rat
    G W Millington
    Department of Physiology, University of Cambridge, UK
    Neuroscience 108:437-45. 2001
    ..is the precursor for at least three melanocortin peptides, alpha-, beta- and gamma-melanocyte-stimulating hormone (MSH), it has been widely assumed that alpha-MSH is the predominant ligand involved...
  49. ncbi High precursor level in maternal blood results from the alternate mode of proopiomelanocortin processing in human placenta
    M L Raffin-Sanson
    Institut Cochin de Genetique Moleculaire, CNRS UPR 1524, Paris, France
    Clin Endocrinol (Oxf) 50:85-94. 1999
    b>ACTH-producing non-pituitary tumours are often associated with altered precursor processing, particularly in the most aggressive ones...
  50. ncbi Plasma levels of corticotroph-type pro-opiomelanocortin derivatives such as beta-lipotropin, beta-endorphin(1-31), or adrenocorticotropic hormone are correlated with severity of postoperative pain
    Reginald Matejec
    Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, Justus Liebig University, Giessen, Germany
    Clin J Pain 22:113-21. 2006
    ..of the neurointermediate lobe; enzymatic processing in the corticotrophs results in the release of adrenocorticotropic hormone, beta-lipotropin, or beta-endorphin...
  51. ncbi State-dependent modulation of feeding behavior by proopiomelanocortin-derived beta-endorphin
    Malcolm J Low
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Ann N Y Acad Sci 994:192-201. 2003
    ....
  52. ncbi Differential effects of fasting and leptin on proopiomelanocortin peptides in the arcuate nucleus and in the nucleus of the solitary tract
    Mario Perello
    Division of Endocrinology, Department of Medicine, Brown University, Rhode Island Hospital, Providence, Rhode Island 02903, USA
    Am J Physiol Endocrinol Metab 292:E1348-57. 2007
    The alpha-melanocyte-stimulating hormone (alpha-MSH), derived from proopiomelanocortin (POMC), is generated by a posttranslational processing mechanism involving the prohormone convertases (PCs) PC1/3 and PC2...
  53. ncbi High levels of endorphin and related pathologies of veterinary concern. A review
    R L Sciorsci
    Department of Veterinary and Agro-Alimentary Sciences, Veterinary Medicine, University of Teramo, Italy
    Immunopharmacol Immunotoxicol 22:575-626. 2000
    ..The use of calcium salts and Naloxone offers a safe and supplementary therapeutical possibility, active in any condition of altered endogenous opioids...
  54. ncbi A role for beta-endorphin in the pathogenesis of human obesity?
    D Giugliano
    Chair of Diabetology and Dietetics, First Faculty of Medicine, University of Naples, Italy
    Horm Metab Res 23:251-6. 1991
    ..Although the problem still awaits a definite answer, it seems not hazardous to hypothesize a role for beta-endorphin in some pathogenetic events associated with human obesity...
  55. ncbi Receptor biology of the melanocortins, a family of neuroimmunomodulatory peptides
    J B Tatro
    Division of Endocrinology, Diabetes, Metabolism and Molecular Medicine, New England Medical Center Hospitals, Boston, Mass, USA
    Neuroimmunomodulation 3:259-84. 1996
    Melanocortins, melanocyte-stimulating hormones (MSH) and adrenocorticotropic hormone (ACTH) are homologous natural peptides derived from pro-opiomelanocortin (POMC)...
  56. ncbi An immunocytochemical approach to the study of beta-endorphin production in human keratinocytes using confocal microscopy
    S B Zanello
    Department of Physiology, Boston University School of Medicine, Massachusetts 02118, USA
    Ann N Y Acad Sci 885:85-99. 1999
    ....
  57. ncbi Localization of pro-opiomelanocortin mRNA transcripts and peptide immunoreactivity in rat heart
    W R Millington
    Department of Basic Medical Science, School of Medicine, University of Missouri Kansas City 64108, USA
    Cardiovasc Res 43:107-16. 1999
    alpha-Melanocyte-stimulating hormone (alpha-MSH), beta-endorphin and other pro-opiomelanocortin-(POMC) derived peptides have been detected in the heart, but it is uncertain whether they are synthesized by cardiomyocytes or by cardiac ..
  58. ncbi SF-1 (steroidogenic factor-1), C/EBPbeta (CCAAT/enhancer binding protein), and ubiquitous transcription factors NF1 (nuclear factor 1) and Sp1 (selective promoter factor 1) are required for regulation of the mouse aldose reductase-like gene (AKR1B7) expre
    C Aigueperse
    , , , France
    Mol Endocrinol 15:93-111. 2001
    ..We show that in adrenals, the pituitary hormone ACTH regulates MVDP gene expression in a coordinate fashion with steroidogenic genes...
  59. ncbi Silent myocardial ischemia in patients with essential hypertension
    A P Yurenev
    Institute of Clinical Cardiology, Russian Academy of Medical Sciences of the USSR, Moscow
    Am J Hypertens 5:169S-174S. 1992
    ..The results suggest that there are different pathogenetic mechanisms of coronary insufficiency in patients with EH, a hypertensive heart, and silent ischemia...
  60. pmc Modulation of host defense by the neuropeptide alpha-MSH
    J M Lipton
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas
    Yale J Biol Med 63:173-82. 1990
    alpha-melanocyte stimulating hormone (alpha-MSH), a peptide that occurs within the brain, the circulation, and other body sites, is a potent antipyretic agent when given centrally or peripherally...
  61. ncbi Mutations in adrenocortical tumors
    M Reincke
    Medical Department II, University of Freiburg, Germany
    Horm Metab Res 30:447-55. 1998
    ..5 associated with IGF II hyperexpression. Constitutive activation of the ACTH receptor-G protein-cAMP signal cascade does not play a role in adrenal tumor formation...
  62. pmc Genetic disruption of gamma-melanocyte-stimulating hormone signaling leads to salt-sensitive hypertension in the mouse
    Xi Ping Ni
    Division of Nephrology, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94143, USA
    J Clin Invest 111:1251-8. 2003
    The gamma-melanocyte-stimulating hormone (gamma-MSH) is a natriuretic peptide derived from the N-terminal region of proopiomelanocortin (POMC). Evidence suggests that it may be part of the coordinated response to a low-sodium diet (LSD)...
  63. ncbi beta-endorphin in plasma and monocytes in juvenile headache
    P A Battistella
    Department of Pediatrics, University of Padua, Padova, Italy
    Headache 36:91-4. 1996
    ....
  64. pmc Major role of cathepsin L for producing the peptide hormones ACTH, beta-endorphin, and alpha-MSH, illustrated by protease gene knockout and expression
    Lydiane Funkelstein
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 283:35652-9. 2008
    The pituitary hormones adrenocorticotropic hormone (ACTH), beta-endorphin, and alpha-melanocyte stimulating hormone (alpha-MSH) are synthesized by proteolytic processing of their common proopiomelanocortin (POMC) precursor...
  65. ncbi Effects of opioid peptides on thyrotropin-releasing hormone release from the rat caecum in vitro
    T Mitsuma
    Fourth Department of Internal Medicine, Aichi Medical University, Japan
    Horm Metab Res 21:301-4. 1989
    ..The elution profile of acid-methanol-extracts of rat caecum on Sephadex G-10 was identical to that of synthetic TRH. The findings suggest that opioid peptides inhibit TRH release from the rat caecum in vitro...
  66. ncbi Morphological changes in the pituitary gland of dogs chronically exposed to exogenous growth hormone
    P Laroque
    Merck Sharp and Dohme Chibret Laboratories, Department of Safety Assessment, Riom, France
    Toxicol Pathol 26:201-6. 1998
    ..method following immunostaining to identify cells containing GH, prolactin (PRL), and adrenocorticotrophic (ACTH) hormones. Administration of pGH resulted in a statistically significant (p < or = 0...
  67. ncbi Identification of proopiomelanocortin-related peptides in the rostral pars distalis of the pituitary in coelacanth: evolutional implications
    Akiyoshi Takahashi
    Laboratory of Molecular Endocrinology, School of Fisheries Sciences, Kitasato University, Sanriku, Ofunato, Iwate 022 0101, Japan
    Gen Comp Endocrinol 130:340-9. 2003
    ..beta-MSH, N-terminal peptide containing gamma-MSH, corticotropin-like intermediate lobe peptide (CLIP), and N-acetyl-beta-endorpin (END) in an extract from the rostral pars distalis of the pituitary by reversed-phase ..
  68. ncbi De novo design, synthesis, and pharmacology of alpha-melanocyte stimulating hormone analogues derived from somatostatin by a hybrid approach
    Guoxia Han
    Departments of Chemistry and Anatomy, University of Arizona, Tucson, Arizona 85721, USA
    J Med Chem 47:1514-26. 2004
    A number of alpha-melanotropin (alpha-MSH) analogues have been designed de novo, synthesized, and bioassayed at different melanocortin receptors from frog skin (fMC1R) and mouse/rat (mMC1R, rMC3R, mMC4R, and mMC5R)...
  69. ncbi The dawn and evolution of hormones in the adenohypophysis
    Hiroshi Kawauchi
    Laboratory of Molecular Endocrinology, School of Fisheries Sciences, Kitasato University, Sanriku, Iwate 022 0101, Japan
    Gen Comp Endocrinol 148:3-14. 2006
    ..In gnathostomes, adrenocorticotropin (ACTH) and melanotropin (MSH) together with beta-endorphins (beta-END) are encoded in a single gene, ..
  70. ncbi Leptin-induced increase in sympathetic nervous and cardiovascular tone is mediated by proopiomelanocortin (POMC) products
    J C Dunbar
    Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201 1928, USA
    Brain Res Bull 50:215-21. 1999
    ..we evaluated the possible involvement of two major products of POMC, alpha-melanocyte stimulating hormone (alpha-MSH) and beta-endorphin, in mediating the effects of leptin on sympathetic activity and mean arterial pressure (MAP) in ..
  71. ncbi beta-Endorphin and propiomelanocortin-correlates peptides response in suspected and confirmed ischemic heart disease during exercise
    C Letizia
    I Patologia Medica,
    Acta Cardiol 51:27-36. 1996
    In this study, we investigated circulating beta-endorphin, ACTH and cortisol in subjects with suspected coronary artery disease (CAD) and in patients with CAD during stress testing...
  72. ncbi Molecular cloning of proopiomelanocortin cDNA and multi-tissue mRNA expression in channel catfish
    Attila Karsi
    USDA ARS Catfish Genetics Research Unit, Thad Cochran National Warmwater Aquaculture Center, P O Box 38, Stoneville, MS 38776, USA
    Gen Comp Endocrinol 137:312-21. 2004
    ..POMC protein contains a signal peptide (SP, Met(1)-Ala(28)), N-terminal peptide (Gln(29)-Glu(101)), adrenocorticotropic hormone (ACTH, Ser(104)-Met(142)), alpha-melanocyte stimulating hormone (alpha-MSH, Ser(104)-Val(116)), ..
  73. ncbi Plasma beta-endorphin, corticotrophin and growth hormone responses to exercise in pubertal and prepubertal children
    O Bouix
    Department of Physiology, Faculty of Medicine, Montpellier, France
    Horm Metab Res 26:195-9. 1994
    ..In this study, we investigated plasma beta-endorphin, ACTH and GH responses to exercise in 40 prepubertal and pubertal children...
  74. ncbi Study of pressure pain and cellular concentration of neurotransmitters related to nociception in episodic tension-type headache patients
    G Mazzotta
    Interuniversity Centre for the Study of Headache and Neurotransmitter Disorders of the C.N.S, University of Perugia, Italy
    Headache 37:565-71. 1997
    ....
  75. doi Structural and functional diversity of proopiomelanocortin in fish with special reference to barfin flounder
    Akiyoshi Takahashi
    School of Marine Biosciences, Kitasato University, Ofunato, Iwate 022 0101, Japan
    Peptides 30:1374-82. 2009
    Proopiomelanocortin (POMC) is a precursor of adrenocorticotropic hormone (ACTH), melanocyte-stimulating hormone (MSH), and endorphin (END). We have characterized POMC systems in barfin flounder...
  76. doi Melanoma targeting with alpha-melanocyte stimulating hormone analogs labeled with fac-[99mTc(CO)3]+: effect of cyclization on tumor-seeking properties
    Paula D Raposinho
    Departamento de Quimica, ITN, Estrada Nacional 10, 2686 953, Sacavem, Portugal
    J Biol Inorg Chem 13:449-59. 2008
    ..Several linear and cyclic radiolabeled alpha-melanocyte stimulating hormone (alpha-MSH) analogs have been proposed to target the melanocortin type 1 receptor (MC1R) overexpressed in melanoma...
  77. ncbi Leech immunocytes contain proopiomelanocortin: nitric oxide mediates hemolymph proopiomelanocortin processing
    M Salzet
    Centre de Biologie Cellulaire, Universite des Sciences et Technologies de Lille, Villeneuve d Ascq, France
    J Immunol 159:5400-11. 1997
    ..the presence of mammalian-like proopiomelanocotropic hormone (POMC), and six of its peptides, including adrenocorticotropic hormone (ACTH) and melanocyte-stimulating hormone (MSH), in the immune tissues of the leech Theromyzon ..
  78. ncbi Humoral factors released during trauma of Aplysia body wall. II. Effects of possible mediators
    B F Cooper
    Department of Physiology and Cell Biology, University of Texas Medical School, Houston 77225
    J Comp Physiol B 159:225-35. 1989
    ..Various humoral signals produce slow effects that contribute to hemostasis, balling up, increased cardiac output, and reflex suppression...
  79. ncbi Dissociation of ACTH, beta-endorphin and cortisol in graded sepsis
    I Legakis
    Department of Endocrinology, Hippokrateion General Hospital, Athens, Greece
    Horm Metab Res 30:570-4. 1998
    ..as related to the degree of severity of a septic process was assessed by measuring plasma levels of beta-endorphin, ACTH and cortisol...
  80. ncbi Presence of the delta-MSH sequence in a proopiomelanocortin cDNA cloned from the pituitary of the galeoid shark, Heterodontus portusjacksoni
    Robert M Dores
    Department of Biological Sciences, University of Denver, Denver, CO 80210, USA
    Gen Comp Endocrinol 133:71-9. 2003
    ..reading frame that is 1032 nucleotides in length and encodes the deduced amino acids sequences for beta-endorphin, ACTH/alpha-MSH, beta-MSH, gamma-MSH, and delta-MSH...
  81. ncbi Effect of naloxone on the adrenal cortex in primary aldosteronism
    F Fallo
    Institute of Semeiotica Medica, University of Padova, Italy
    Am J Hypertens 1:280-2. 1988
    ..In normals, APA, and IHA, naloxone caused a significant increase in plasma cortisol and no change in ACTH, renin activity (PRA), and aldosterone levels. All subjects were retested after dexamethasone 2 mg...
  82. pmc The prenatal development profile of expression of opioid peptides and receptors in the mouse brain
    R A Rius
    Section on Cellular Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    Brain Res Dev Brain Res 58:237-41. 1991
    ..In a comparative study of the binding of beta-endorphin 1-31, its truncated form (1-27) and their N-acetyl derivatives to E14.5 brain membranes, beta-endorphin 1-31 exhibited the highest affinity...
  83. ncbi Central effects of atrial natriuretic peptide on plasma catecholamines, vasopressin, renin and beta-endorphin and on renal excretory functions in the dog
    E Szeczepańska-Sadowswka
    Department of Clinical and Applied Physiology, Warsaw Academy of Medicine, Poland
    Horm Metab Res 22:323-8. 1990
    ..In time control experiments plasma hormones concentration and renal excretory functions were not significantly influenced. The results suggest that central ANP may affect the sympatho-adrenal outflow...
  84. ncbi cDNA cloning of proopiomelanocortin (POMC) and mass spectrometric identification of POMC-derived peptides from snake and alligator pituitaries
    Yuki Kobayashi
    School of Fisheries Sciences, Kitasato University, Sanriku, Ofunato, Iwate 022 0101, Japan
    Gen Comp Endocrinol 152:73-81. 2007
    Proopiomelanocortin (POMC) is the precursor of melanocyte-stimulating hormone (MSH) and beta-endorphin, and is suggested to have evolved by the insertion and deletion of ancestral MSH segments...
  85. ncbi T3 reverses the changes in met-enkephalin and beta-endorphin contents in the anterior lobe, but not the neuro-intermediate lobe of the pituitary of rats rendered hypothyroid by PTU-treatment
    F Tang
    Department of Physiology, University of Hong Kong
    Horm Metab Res 20:323-6. 1988
    ..In conclusion, while the effects on the anterior lobe are probably due to a deficiency in thyroid hormones, the mechanism for the decrease of opioid peptide contents in the neurointermediate lobe is still unclear...
  86. ncbi Secretion of major adrenal androgens following ACTH administration in obese women with different body fat distribution
    V Vicennati
    Department of Internal Medicine and Gastroenterology, S. Orsola Hospital, University of Bologna, Italy
    Horm Metab Res 30:133-6. 1998
    ..underwent the following protocol study that included a) baseline determination of major adrenal androgens, b) an ACTH test, performed by administering two boli of ACTH (Synacthen, 0.2 microg/Kg BW, e.v...
  87. ncbi Brain potentials and attention after acute and subchronic intranasal administration ofACTH 4-10 and desacetyl-alpha-MSH in humans
    R Smolnik
    Department of Internal Medicine, Clinical Neuroendocrinology, University of Lubeck, Germany
    Neuroendocrinology 70:63-72. 1999
    Neuropeptides related to adrenocorticotropin (ACTH) are potent regulators of neurobehavioral functions...
  88. ncbi Nucleotide sequence and expression of three subtypes of proopiomelanocortin mRNA in barfin flounder
    Akiyoshi Takahashi
    School of Fisheries Sciences, Kitasato University, Sanriku, Ofunato, Iwate 022 0101, Japan
    Gen Comp Endocrinol 141:291-303. 2005
    Melanophore-stimulating hormone (MSH) has been shown to be associated with food intake in addition to body color change in teleosts. MSH is encoded by a proopiomelanocortin (POMC) gene together with endorphin (END)...
  89. ncbi Peripheral plasma levels of beta-endorphin in alcoholics and highly trained athletes and the relationship to a measure of central opioid tone
    W J Inder
    Department of Endocrinology, Christchurch Hospital, New Zealand
    Horm Metab Res 30:523-5. 1998
    ..There was a positive correlation between plasma beta-endorphin level at 1100 hours and the subsequent ACTH incremental response to naloxone in the group as a whole (r=0.48, p=0.004)...
  90. pmc Peripheral administration of the N-terminal pro-opiomelanocortin fragment 1-28 to Pomc-/- mice reduces food intake and weight but does not affect adrenal growth or corticosterone production
    Anthony P Coll
    Departments of Clinical Biochemistry and Medicine, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge CB2 2XY, UK
    J Endocrinol 190:515-25. 2006
    ..POMC-derived ACTH is vital for normal adrenal function and the melanocortin alpha-MSH plays a key role in appetite control and energy ..
  91. ncbi Presence of pro-opiomelanocortin mRNA in the rat medial prefrontal cortex, nucleus accumbens and ventral tegmental area: studies by RT-PCR and in situ hybridization techniques
    Mariana Leriche
    Instituto Nacional de Psiquiatría Ramón de la Fuente, Calzada Mexico Xochimilco 101, Col San Lorenzo Huipulco, 14370 México DF, Mexico
    Neuropeptides 41:421-31. 2007
    ..actives neuropeptides, such as beta-lipotropin (beta-LPH), beta-endorphin (beta-END), adenocorticotropic hormone (ACTH) and alpha-melanocyte-stimulating hormone (alpha-MSH)...
  92. doi Differential expressions of melanocortin receptor subtypes in melanophores and xanthophores of barfin flounder
    Yuki Kobayashi
    School of Marin Biosciences, Kitasato University, Ofunato, Iwate 022 0101, Japan
    Gen Comp Endocrinol 168:133-42. 2010
    alpha-Melanocyte-stimulating hormone (alpha-MSH) is a member of the melanocortin (MC) family, and the MC receptor (MCR) is a member of the G protein-coupled receptor (GPCR) superfamily...
  93. ncbi Effect of sandostatin on CRF-stimulated secretion of ACTH, beta-lipotropin and beta-endorphin
    C Invitti
    First Medical Clinic, University of Milan, Italy
    Horm Metab Res 23:233-5. 1991
    The influence exerted by somatostatin on the secretion of ACTH and opioid peptides has still to be clarified. To gain further information on this issue, we performed in 10 normal volunteers two CRF tests (100 micrograms i.v...
  94. ncbi The effect of Ca and Mg supplementation and the role of the opioidergic system on the development of DOCA-salt hypertension
    K Hattori
    First Department of Internal Medicine, Kobe University School of Medicine, Japan
    Am J Hypertens 4:72-5. 1991
    ..416, P less than .01) and beta-END (r = 0.436, P less than .005). A negative correlation was also observed between RBC-Na and beta-END (r = 0.437, P less than .005).(ABSTRACT TRUNCATED AT 250 WORDS)..
  95. ncbi Alteration of opioid peptide circadian rhythm in cancer patients
    S Barni
    Division of Radiation Oncology, Ospedale San Gerardo, Monza, Milano, Italia
    Tumori 74:357-60. 1988
    ..This study shows an altered opioid activity in human neoplasms, whose clinical significance remains to be determined...
  96. ncbi Cloning of a proopiomelanocortin cDNA from the pituitary of the Australian lungfish, Neoceratodus forsteri: analyzing trends in the organization of this prohormone precursor
    R M Dores
    Department of Biological Sciences, University of Denver, Denver, Colorado 80208, USA
    Gen Comp Endocrinol 116:433-44. 1999
    ..sequences from the Australian lungfish and the African lungfish indicated that the deduced amino acid sequences for ACTH, beta-MSH, and beta-endorphin were over 90% identical...
  97. ncbi Effect of prolonged subcutaneous administration of interleukin-2 on the circadian rhythms of cortisol and beta-endorphin in advanced small cell lung cancer patients
    S Spinazze
    Division of Medical Oncology A, Istituto Nazionale Tumori, Milan, Italy
    Tumori 77:496-9. 1991
    ..This suggests that the interleukin-2-induced cortisol rise has no relevant clinical importance in antagonizing the activation of an effective antitumor immune response during cancer immunotherapy with interleukin-2...
  98. ncbi Neuroendocrinology of the pituitary gland
    S Reichlin
    Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts 02111
    Toxicol Pathol 17:250-5. 1989
    ..Specific neuropeptides have been isolated which stimulate the secretion of ACTH (CRF, corticotrophin releasing hormone), TSH (TRH, thyrotropin releasing hormone), GH (GHRH, growth hormone ..
  99. ncbi Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus
    M W Schwartz
    Department of Medicine, University of Washington, Pugent Sound VA Health Care System, Seattle 98108, USA
    Diabetes 46:2119-23. 1997
    ..These findings support the hypothesis that leptin signaling in the brain involves activation of the hypothalamic melanocortin system...
  100. ncbi Investigation of the melanocyte stimulating hormones on food intake. Lack Of evidence to support a role for the melanocortin-3-receptor
    C R Abbott
    ICSM Endocrine Unit, Hammersmith Hospital, W12 0NN, London, UK
    Brain Res 869:203-10. 2000
    ..The pro-opiomelanocortin product alpha-melanocyte stimulating hormone (alpha-MSH), an MC3/4-R agonist, decreases food intake following intracerebroventricular (ICV) injection in rats...
  101. ncbi Event-related brain potentials and working memory function in healthy humans after single-dose and prolonged intranasal administration of adrenocorticotropin 4-10 and desacetyl-alpha-melanocyte stimulating hormone
    R Smolnik
    Department of Clinical Neuroendocrinology, University of Lubeck, Germany
    J Clin Psychopharmacol 20:445-54. 2000
    Neuropeptides of the adrenocorticotropin/melanocorticotropin (ACTH/MSH) family are most potent modulators of cognitive function...

Research Grants72

  1. REGULATION OF ANTERIOR PITUITARY FUNCTION BY POMC
    Sharon Wardlaw; Fiscal Year: 1990
    ....
  2. OPIOID REGULATION OF POMC IN THE HYPOTHALAMUS
    Sharon Wardlaw; Fiscal Year: 2000
    ..receptor will be studied in the hypothalamus and correlated with the functional effects of these treatments on ACTH, corticosterone and IL-6 release in chronically catheterized animals...
  3. OPIOMELANOCORTIN PEPTIDES AND CARDIOVASCULAR REGULATION
    George Kunos; Fiscal Year: 1999
    ..pressure and heart rate by the release of the proopiomelanocortin (PMOC)-derived peptides beta-endorphin and alpha-MSH which, in turn, activate distinct opiate and melanocortin receptors located in the nucleus tractus solitarii (NTS)...
  4. REGULATION OF SECRETION OF POMC PEPTIDES IN BRAIN
    LEONARD KAPCALA; Fiscal Year: 1991
    Various, behavioral, biochemical and neuromodulatory effects have been produced in brain by ACTH, alpha-MSH, beta- endorphin, and related peptides derived from processing of their precursor, pro-opiomelanocortin (POMC), which is ..
  5. Brain mast cells and Chronic Fatigue Syndrome
    Theoharis C Theoharides; Fiscal Year: 2013
    ..The proposed research is hypothesis-driven, is based on strong preliminary evidence, is innovative with high likelihood for novel findings with applicability to humans. ..
  6. David E Fisher; Fiscal Year: 2015
    ..This 2-endorphin - fatigue axis offers a profound treatment opportunity to improve quality of life in cancer patients, which we will examine in a human clinical trial and a series of preclinical animal studies. ..
  7. CHRISTINE MICHELE BURT SOLORZANO; Fiscal Year: 2016
    ..Aim 2 will use low-dose hydrocortisone and leuprolide therapy to test whether short-term suppression of adrenocorticotropin or gonadotropin production can reduce androgen levels in overweight girls with androgen excess...
  8. LATRICE DOREEN FAULKNER; Fiscal Year: 2015
    ..Collectively, these experiments will establish whether the absence of insulin and leptin signaling in POMC neurons elevates LH pulse secretion and testosterone release, thus impairing the steroidal negative feedback. ..
  9. Cathepsin L in the Biosynthesis of Enkephalins and beta-Endorphin Opioid Peptides
    Steven J Bark; Fiscal Year: 2012
    ....
  10. MARTIN JEFFREY KELLY; Fiscal Year: 2016
    ....
  11. BETA ENDORPHIN NEURONS AND THE CONTROL OF HOMEOSTASIS
    Martin Kelly; Fiscal Year: 2009
    ..abstract_text> ..
  12. YVETTE FRANCE TACHE; Fiscal Year: 2015
    ....
  13. David W Self; Fiscal Year: 2014
    ..Together, these studies will determine the role of persistent neuroadaptations in endogenous mu opiate receptor systems in the increased propensity for cocaine relapse in prolonged abstinence. ..
  14. TUMOR CELL SYNTHESIS AND SECRETION OF PEPTIDE HORMONES
    David Orth; Fiscal Year: 1991
    ..It is directed primarily at ACTH and the other proopiomelanocortin (POMC) peptides...
  15. Neural-Specific Regulation of POMC Gene Expression
    Malcolm Low; Fiscal Year: 2005
    ....
  16. INTERLEUKIN REGULATION OF PROOPIOMELANOCORTIN GENE
    S Brown; Fiscal Year: 1990
    ..vivo administration of interleukin- 1 (IL-1) or of interleukin-2 (IL-2) results in increases of plasma adrenocorticotropic hormone or corticotropin (ACTH) indicates that monokines and lymphokines affect neuroendocrine function...
  17. PRO-OPIOMELANOCORTIN SYNTHESIS IN TESTES
    Nathaniel Mills; Fiscal Year: 1992
    ..and is a precursor to several very important and biologically active peptides which include adreno corticotropin (ACTH), melanocyte- stimulating hormone (MSH), and beta-endorphin...
  18. POMC PROCESSING & BETA-ENDORPHIN RELATED OPIOID PEPTIDE
    Vivian Hook; Fiscal Year: 2000
    ..for the 70 kDa aspartic proteinase, PC 1/3, and PC2 with respect to kinetics, cleavage sites, and beta-endorphin/ACTH products...
  19. STRUCTURAL DETERMINANTS IN REGULATION OF POMC PROCESSING
    Theodore Friedman; Fiscal Year: 1999
    ..Pro-opiomelanocortin (POMC) is the precursor of the biologically active peptides, ACTH and beta-endorphin. Heroin addicts have decreased levels of beta-endorphin...
  20. Molecular Genetics of the HPA(I) Axis
    Phillip Danielson; Fiscal Year: 2002
    ..the pituitary express proopiomelanocortin (POMC), a precursor protein from which the polypeptide hormone, adrenocorticotropin (ACTH), is post-translationally released. ACTH is well established as a critical link in this network...
  21. Transcriptional Control of Obesity
    DEBORAH GOOD; Fiscal Year: 2005
    ..were identical between the two groups, levels of two processed forms of POMC, beta-endorphin (betaEND) and adrenocorticotropin hormone (ACTH) were dramatically reduced, while levels of alphaMSH were modestly reduced in the N2KO ..
  22. Melanocortin system stress and HPA axis
    Xin Yun Lu; Fiscal Year: 2010
    ..This system consists of two opposite signaling components, the endogenous agonist alpha-MSH and the endogenous antagonist AgRP...
  23. Discovery of Alpha-MSH Analogs for Skin Cancer Prevention
    Zalfa Abdel Malek; Fiscal Year: 2009
    ..hMC) and its endogenous ligands a-melanocyte stimulating hormone (a-melanocortin;a-MSH) and adrenocorticotropic hormone (ACTH) in photoprotection against skin cancer...
  24. Gonadal Steroid Receptors and the Hypothalamo-Pituitary-Adrenal Axis
    Robert J Handa; Fiscal Year: 2013
    ..The reproductive steroids, E and T can also modulate stress responses. Circulating E enhances stress activated ACTH and CORT secretion. In contrast, T decreases the gain of the HPA axis...
  25. Fetal and Neonatal Pituitary-Adrenal Function
    James C Rose; Fiscal Year: 2010
    ..The first hypothesis is that the decrease in CRH R1 receptor expression and decline in ACTH responses to CRH observed in late gestation are the result of the increase in fetal plasma cortisol occurring then...
  26. CONTROL OF CORTICOTROPIN DURING PREGNANCY
    Maureen Keller Wood; Fiscal Year: 1993
    ..The research project which the candidate will be investigating involves control of ACTH during pregnancy...
  27. The role of BNST CGRP in stress-enhanced anxiety behavior and HPA-axis function
    Kelly S Sink; Fiscal Year: 2013
    ..behavior (acoustic startle and defensive freezing), neuroendocrine responses (serum corticosterone and adrenocorticotropin hormone), and changes in mRNA expression of CGRP, and the CGRP receptor components RAMP1 and calcitonin ..
  28. Haifei Shi; Fiscal Year: 2015
    ....
  29. Arcuate nucleus glutamatergic neurons modulate energy homeostasis
    Anthony N van den Pol; Fiscal Year: 2013
    ..abstract_text> ..
  30. Increased vulnerability of BDNF deficient mice to mild stress
    JULIE GORTON HENSLER; Fiscal Year: 2010
    ..We will measure plasma levels of adrenocorticotropic hormone (ACTH) and corticosterone as a physiological indication of the reactivity of BDNF() mice to stress ..
  31. De Pei Li; Fiscal Year: 2016
    ..of corticotrophin-releasing hormone (CRH)-expressing parvocellular neurons increases pituitary adrenocorticotropic hormone (ACTH) release and subsequent corticosterone (CORT) secretion under both basal and stressed conditions...
  32. Mechanism of HPA Axis Activation: Role of Nicotinic Acid Receptor in the Brain
    Jang H Youn; Fiscal Year: 2012
    ..We will also examine the effects of starvation and diabetes on plasma [unreadable]HB, ACTH, and corticosterone levels in wild-type and NA-R knockout mice and test whether the HPA axis is activated in wild-..
  33. Alan G Watts; Fiscal Year: 2016
    ..They play a critical role in generating ACTH and glucocorticoid responses to virtually all stressors, but particularly those generated within the body such as ..
  34. Systemic Factors that Maintain a Young Liver Phenotype
    Roy G Smith; Fiscal Year: 2012
    ..Ghrelin levels decline as a function of age. Our research is designed to test whether replacing this hormone with a more stable form will provide health and quality of life benefits during aging. ..
  35. Edward J Wagner; Fiscal Year: 2015
    ....
  36. DIPAK KUMAR SARKAR; Fiscal Year: 2016
    ....
  37. MALCOLM JAMES LOW; Fiscal Year: 2016
    ....
  38. Interaction of Estrogen and AMPK in the Hypothalamus
    Jessica Healy; Fiscal Year: 2012
    ..The proposed project will investigate the cellular mechanisms underlying the interaction between food intake and reproductive hormones, and the results may be useful in mitigating the pathological effects of certain types of obesity. ..
  39. Barry E Levin; Fiscal Year: 2014
    ....
  40. 18F-beta-Endorphin Imaging: Translational Study of an Opioid Peptide Radiotracer
    BRIAN contact REED; Fiscal Year: 2010
    ....
  41. Rajat Singh; Fiscal Year: 2016
    ..POMC neurons express POMC that is processed to generate [unreadable]-melanocyte stimulating hormone ([unreadable]-MSH), which promotes energy expenditure...
  42. Inflammatory Cytokine regulation of POMC and Orexin neurons in cachexia.
    AARON GROSSBERG; Fiscal Year: 2012
    ..This research is designed to understand how disease causes these devastating reductions in eating and activity level as a means to develop new therapies. ..
  43. Joel K Elmquist; Fiscal Year: 2016
    ..Results from these studies will advance our understanding of the serotoninergic circuits necessary to permit the design of effective treatment strategies for obesity and diabetes. ..
  44. MALCOLM JAMES LOW; Fiscal Year: 2016
    ....
  45. Neural Basis of Pubertal Shifts in Stress Reactivity
    Russell D Romeo; Fiscal Year: 2012
    ..For instance, in response to an acute stressor, adrenocorticotropic hormone (ACTH) and corticosterone levels in prepubertal animals remain elevated for twice as long compared to ..
  46. Phosphodiesterase-3B signaling in the Hypothalamus and Obesity
    Abhiram Sahu; Fiscal Year: 2013
    ..Overall, these studies will define the critical role of PDE3B signaling in the hypothalamus in the context of the physiology and pathophysiology of energy homeostasis. ..
  47. Endogenous G-Protein Coupled Receptor Antagonists
    Carrie Haskell-Luevano; Fiscal Year: 2012
    ..This research project proposes to generate knowledge for the rational design of molecules as potential therapeutic agents to prevent or treat the diseases associated with over or under eating. ..
  48. Hypothalamic Mechanisms in Cachexia
    Daniel L Marks; Fiscal Year: 2013
    ..Our data argues strongly that the hypothalamic melanocortin system plays a critical role in the transduction of illness-induced cachexia and therefore represents an important target for future therapeutic intervention. ..
  49. Physiological Role of CNS GLP-2 Receptor in Energy Homeostasis
    Xinfu Guan; Fiscal Year: 2010
    ....
  50. KARL LEONARD INSOGNA; Fiscal Year: 2015
    ..2008), we also predict that increasing ROS exposure of the melanocortin system during aging is a critical contributor to aging-associated bone loss and the pathogenesis of osteoporosis. ..
  51. Richard E Mains; Fiscal Year: 2016
    ....
  52. Effects of Neonatal MDMA on Brain and Behavior
    Charles V Vorhees; Fiscal Year: 2010
    ..triggers a unique cascade of events beginning with overactivation of the stress response pathway (release of CRF, ACTH, CORT) but in which normal feedback mechanisms fail to operate correctly...
  53. Regulation of Hypothalamic POMC by Leptin
    Christian Bjorbaek; Fiscal Year: 2010
    ..Obtained data will therefore be relevant for future identification of novel anti-obesity/diabetes drug pathways/targets. ..
  54. Altering Energy Balance by Systemic Delivery of RNAi to the Neuroendocrine Brain
    Sergio R Ojeda; Fiscal Year: 2013
    ..We also anticipate that these studies will provide the basis for new delivery strategies to the brain for basic research purposes and emerging therapies. ..
  55. A carboxypeptidase in the regulation of hypothalamic circuitry
    Sabrina Diano; Fiscal Year: 2013
    ..The major anorexigenic peptide in the hypothalamus is alpha-melanocyte-stimulating hormone (1-MSH), the product of the pro-opiomelanocortin (POMC) gene...
  56. Todd E Thiele; Fiscal Year: 2014
    ..MC peptides include a-melanocyte stimulating hormone (a-MSH), which is synthesized in the arcuate nucleus of the hypothalamus and projects to many brain regions of known ..
  57. Sabrina Diano; Fiscal Year: 2016
    ....
  58. Sharon L Wardlaw; Fiscal Year: 2015
    ..The physiology of this system, consisting of the proopiomelanocortin (POMC)-derived MSH peptides, the MSH antagonist, agouti related protein (AgRP) and the brain melanocortin receptors, has been well ..
  59. AARON JEFFREY MERCER; Fiscal Year: 2014
    ....
  60. Alexander Neumeister; Fiscal Year: 2014
    ..Stress hormones and opioid peptides (ACTH, cortisol, beta-endorphin) will be measured in an exploratory analysis of the relationship between glucocorticoid ..
  61. Hypothalamic GABAergic Action and Energy Homeostasis
    Qingchun Tong; Fiscal Year: 2010
    ..abstract_text> ..
  62. Young Hwan Jo; Fiscal Year: 2016
    ..Hence the proposed studies will provide novel insights into the neurobiology of melanocortin system in general and its specific role in the control of energy balance in particular. ..
  63. Oline K Ronnekleiv; Fiscal Year: 2016
    ..Understanding the convergence of leptin and E2 signaling in arcuate kisspeptin neurons will provide insight into the fundamental role of these hormones in conveying metabolic cues to the reproductive axis. ..
  64. Hypothalamic Regulation of Energy Homeostasis
    Sharon Wardlaw; Fiscal Year: 2004
    ..Studies will center on the regulation of proopiomelanocortin (POMC) and the POMC-denved peptides, alpha-MSH, gamma-MSH and beta-EP, together with the newly discovered agouti related protein (AGRP) which is synthesized in ..
  65. CYTOKINES AND HYPOTHALAMIC-PITUITARY-IMMUNE INTERACTIONS
    Sharon Wardlaw; Fiscal Year: 2007
    ..Alpha-MSH which is derived from the proopiomelanocortin (POMC) precursor protein, is synthesized in the periphery and can be ..
  66. Surgical Wound Repair: Role of A Neuroendothelial Axis
    NICOLE SIMONE GIBRAN; Fiscal Year: 2010
    ..2) To determine whether the neuropeptide, alpha melanocyte stimulating hormone regulates endothelial cell inflammatory responses, proliferation or migration...
  67. POMC Processing and Beta-Endorphine-Related Opioid Peptides
    Vivian Y H Hook; Fiscal Year: 2010
    ..New findings from this project will enhance our knowledge of the complexity of biosynthetic mechanisms for endogenous opioid and neuropeptide systems. ..
  68. Coleus forskohlii extract: melanization and UV protection by a natural product
    JOHN DORAZIO; Fiscal Year: 2009
    ..adenylate cyclase activation and cAMP generation when bound by its natural ligand, melanocyte stimulating hormone (MSH)...
  69. Obesity is a Surgical Problem
    Michael W Mulholland; Fiscal Year: 2013
    ..That system contains alpha melanocyte-stimulating hormone ([unreadable]-MSH) and melanocortin receptor (MCR) subtypes MC3R and MC4R...
  70. PITUITARY KALLIKREIN & PROHORMONE PROCESSING
    CLAUD POWERS; Fiscal Year: 1992
    ..have found that TK exhibits patterns of tissue specific expression and physiological regulation closely paralleling MSH and beta-endorphin in the intermediate lobe, and prolactin (PRL) in the anterior pituitary lobe (AP)...
  71. Serpin Protease Inhibitors & Opioid Neuropeptides
    Vivian Hook; Fiscal Year: 2006
    ..Serpin regulation of opioid peptides that mediate analgesia and stress may lead to development of new therapeutic approaches in pain and neurologic disease. ..
  72. HYPOTHALAMIC CONTROL OF FEEDING AND METABOLISM
    ROGER CONE; Fiscal Year: 2003
    ..Finally, the specific hypothesis that altered levels of POMC gene expression may be a risk factor for obesity will be directly tested by Dr. Boston and his collaborators (project II). ..