ACP1

Summary

Gene Symbol: ACP1
Description: acid phosphatase 1, soluble
Alias: HAAP, LMW-PTP, LMWPTP, low molecular weight phosphotyrosine protein phosphatase, LMW-PTPase, acid phosphatase of erythrocyte, adipocyte acid phosphatase, cytoplasmic phosphotyrosyl protein phosphatase, low molecular weight cytosolic acid phosphatase, protein tyrosine phosphatase, red cell acid phosphatase 1, testicular secretory protein Li 37
Species: human

Top Publications

  1. doi Body mass index and acid phosphatase locus 1 in diabetic disorders
    F Gloria-Bottini
    Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, School of Medicine, Via Montpellier 1, 00133 Rome, Italy
    Acta Diabetol 47:139-43. 2010
  2. ncbi Type 1 diabetes: evidence of interaction between ACP1 and ADA1 gene polymorphisms
    Patrizia Saccucci
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Med Sci Monit 15:CR511-517. 2009
  3. ncbi Risk of type 1 diabetes in childhood and maternal age at delivery, interaction with ACP1 and sex
    N Bottini
    Burhnam Institute, La Jolla, California, USA
    Diabetes Metab Res Rev 21:353-8. 2005
  4. pmc The genetics of feto-placental development: a study of acid phosphatase locus 1 and adenosine deaminase polymorphisms in a consecutive series of newborn infants
    Fulvia Gloria-Bottini
    Department of Biopathology and Imaging Diagnostics, Division of Human Population Biopathology and Environmental Pathology, University of Rome Tor Vergata, Rome, Italy
    Reprod Biol Endocrinol 6:38. 2008
  5. ncbi Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation
    Keith D Kikawa
    Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 277:39274-9. 2002
  6. ncbi Association of the acid phosphatase (ACP1) gene with triglyceride levels in obese women
    Nunzio Bottini
    The Burnham Institute, La Jolla, CA, USA
    Mol Genet Metab 77:226-9. 2002
  7. ncbi LMW-PTP associates and dephosphorylates STAT5 interacting with its C-terminal domain
    Stefania Rigacci
    Department of Biochemical Sciences, University of Florence, Viale Morgagni 50, Florence 50134, Italy
    Biochem Biophys Res Commun 312:360-6. 2003
  8. doi Low molecular weight protein tyrosine phosphatase genetic polymorphism and susceptibility to cancer development
    I Alho
    Genetics Laboratory, Metabolism and Endocrinology Center, Lisbon Medical School, Av Prof Egas Moniz, Edificio Egas Moniz, P1C, 1649 028 Lisbon, Portugal
    Cancer Genet Cytogenet 181:20-4. 2008
  9. pmc Evidence for sex-specific associations between variation in acid phosphatase locus 1 (ACP1) and insulin sensitivity in Mexican-Americans
    Yu Hsiang Shu
    Department of Preventive Medicine, Division of Biostatistics, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
    J Clin Endocrinol Metab 94:4094-102. 2009
  10. doi The interaction of ACP1, ADA1, diabetes and gender in coronary artery disease
    Fulvia Gloria-Bottini
    Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Italy
    Am J Med Sci 340:103-8. 2010

Research Grants

  1. Osteoclastic Protein-Tyrosine Phosphatase and Resorption
    Kin Hing William Lau; Fiscal Year: 2013
  2. FAWAZ GEORGE HAJ; Fiscal Year: 2015
  3. Zhong Yin Zhang; Fiscal Year: 2014
  4. Dae Joon Kim; Fiscal Year: 2016
  5. Phosphatase Regulation of Olfactory Bulb Mitral Cell Activity
    Melissa Cavallin Johnson; Fiscal Year: 2011
  6. Radhakrishna Rao; Fiscal Year: 2014
  7. Mechanisms for the Effects of Hypothalamic PTP1B on Energy Balance
    KARYN JOANNE CATALANO; Fiscal Year: 2010
  8. Frank A Anania; Fiscal Year: 2016
  9. Novel anti-toxin compounds against Yersinia infections
    Maurizio Pellecchia; Fiscal Year: 2010
  10. Gloria Lee; Fiscal Year: 2016

Detail Information

Publications482 found, 100 shown here

  1. doi Body mass index and acid phosphatase locus 1 in diabetic disorders
    F Gloria-Bottini
    Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, School of Medicine, Via Montpellier 1, 00133 Rome, Italy
    Acta Diabetol 47:139-43. 2010
    The polymorphic enzyme acid phosphatase locus 1 (ACP1) is a candidate gene for obesity disorders. The enzyme is able to dephosphorylate the insulin receptor...
  2. ncbi Type 1 diabetes: evidence of interaction between ACP1 and ADA1 gene polymorphisms
    Patrizia Saccucci
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Med Sci Monit 15:CR511-517. 2009
    b>ACP1 (acid phosphatase locus 1, a cytosolic low-molecular-weight phosphotyrosin phosphatase) and ADA1 (adenosine deaminase locus 1) are two polymorphic systems involved in immune reactions...
  3. ncbi Risk of type 1 diabetes in childhood and maternal age at delivery, interaction with ACP1 and sex
    N Bottini
    Burhnam Institute, La Jolla, California, USA
    Diabetes Metab Res Rev 21:353-8. 2005
    We have investigated the possible role of ACP1 (also known as cLMWPTP: cytosolic low molecular weight phosphotyrosine phosphatase), a highly polymorphic enzyme involved in signal transduction of T-cell receptor, insulin receptor and other ..
  4. pmc The genetics of feto-placental development: a study of acid phosphatase locus 1 and adenosine deaminase polymorphisms in a consecutive series of newborn infants
    Fulvia Gloria-Bottini
    Department of Biopathology and Imaging Diagnostics, Division of Human Population Biopathology and Environmental Pathology, University of Rome Tor Vergata, Rome, Italy
    Reprod Biol Endocrinol 6:38. 2008
    ..Deviation from a balanced development of the feto-placental unit has been found to be associated with perinatal morbidity and mortality and with cardiovascular diseases in adulthood...
  5. ncbi Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation
    Keith D Kikawa
    Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 277:39274-9. 2002
    ..These results suggest a role for LMW-PTP in transformation progression and link its oncogenic potential to EphA2...
  6. ncbi Association of the acid phosphatase (ACP1) gene with triglyceride levels in obese women
    Nunzio Bottini
    The Burnham Institute, La Jolla, CA, USA
    Mol Genet Metab 77:226-9. 2002
    The acid phosphatase (ACP1) locus codes for a low molecular weight protein tyrosine phosphatase (LMPTP) that is found ubiquitously in human tissues...
  7. ncbi LMW-PTP associates and dephosphorylates STAT5 interacting with its C-terminal domain
    Stefania Rigacci
    Department of Biochemical Sciences, University of Florence, Viale Morgagni 50, Florence 50134, Italy
    Biochem Biophys Res Commun 312:360-6. 2003
    ....
  8. doi Low molecular weight protein tyrosine phosphatase genetic polymorphism and susceptibility to cancer development
    I Alho
    Genetics Laboratory, Metabolism and Endocrinology Center, Lisbon Medical School, Av Prof Egas Moniz, Edificio Egas Moniz, P1C, 1649 028 Lisbon, Portugal
    Cancer Genet Cytogenet 181:20-4. 2008
    ..Human acid phosphatase 1 (ACP1) is genetically polymorphic, and three common alleles segregating at the ACP1 locus on the short arm of chromosome ..
  9. pmc Evidence for sex-specific associations between variation in acid phosphatase locus 1 (ACP1) and insulin sensitivity in Mexican-Americans
    Yu Hsiang Shu
    Department of Preventive Medicine, Division of Biostatistics, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
    J Clin Endocrinol Metab 94:4094-102. 2009
    Acid phosphatase locus 1 (ACP1) is a low molecular weight tyrosine phosphatase that has been shown to be an important regulator of insulin receptor signaling.
  10. doi The interaction of ACP1, ADA1, diabetes and gender in coronary artery disease
    Fulvia Gloria-Bottini
    Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Italy
    Am J Med Sci 340:103-8. 2010
    Previous separate studies have shown associations of coronary artery disease (CAD) with acid phosphatase locus 1 (ACP1) and adenosine deaminase locus 1 (ADA1) genetic polymorphisms...
  11. doi Is there a role of ACP1-ADA1 genetic complex in immune reaction? Association with T1D and with past malarial morbidity
    Fulvia Gloria-Bottini
    Department of Biopathology and Imaging Diagnostics, University of Tor Vergata, Rome, Italy
    Am J Med Sci 340:268-70. 2010
    In this article, we confirm the positive association of acid phosphatase locus 1 (ACP1)*A/adenosine deaminase locus 1 (ADA1)*2 gametic type with type 1 diabetes (T1D) previously reported and show a negative correlation between the ..
  12. doi Association between ACP(1) genetic polymorphism and favism
    V Polzonetti
    Laboratory of Applied Biochemistry, School of Bioscience and Biotechnology, University of Camerino, Camerino, Italy
    Genet Mol Res 10:878-84. 2011
    ..faba extract. Phenotypes A, CA and C had extremely low enzymatic activity levels, which would lead to low levels of reduced glutathione and bring about erythrocyte lysis...
  13. pmc Association of acid phosphatase locus 1*C allele with the risk of cardiovascular events in rheumatoid arthritis patients
    María Teruel
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN CSIC, Avd, del Conocimiento s n, 18010, Granada, Spain
    Arthritis Res Ther 13:R116. 2011
    Acid phosphatase locus 1 (ACP1) encodes a low molecular weight phosphotyrosine phosphatase implicated in a number of different biological functions in the cell...
  14. doi Acid phosphatase locus 1 genetic polymorphism and cancer grading
    Fulvia Gloria-Bottini
    Division of Human Populations Biopathology and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, School of Medicine, University of Rome Tor Vergata, Rome, Italy
    Am J Med Sci 344:32-4. 2012
    ..In this article, the authors have studied the relationship between ACP(1) genotype and grade in colon and endometrium cancers...
  15. pmc p53 codon 72 polymorphism and coronary artery disease: evidence of interaction with ACP₁
    Fulvia Gloria-Bottini
    Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Rome, Italy
    Med Sci Monit 18:CR712-5. 2012
    ..Since ACPACP₁ is associated with coronary artery disease (CAD), we searched for possible interactions between this enzyme and p53 codon 72 polymorphism with regard to their effects on susceptibility to CAD...
  16. ncbi Activation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight phosphotyrosine phosphatase (LMPTP)
    Nunzio Bottini
    Program of Signal Transduction, La Jolla Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 277:24220-4. 2002
    ..The ZAP-70 Y292F mutant was not affected by LMPTP. Our results indicate that LMPTP, like CD45, dephosphorylates a negative regulatory tyrosine site in a protein-tyrosine kinase and thereby strengthens T cell receptor signaling...
  17. ncbi Beta-catenin interacts with low-molecular-weight protein tyrosine phosphatase leading to cadherin-mediated cell-cell adhesion increase
    Maria Letizia Taddei
    Dipartimento di Scienze Biochimiche, Universita degli Studi di Firenze, 50134 Florence, Italy
    Cancer Res 62:6489-99. 2002
    ..Low-molecular-weight protein tyrosine phosphatase (LMW-PTP) is a ubiquitous PTP implicated in the regulation of mitosis and cytoskeleton rearrangement...
  18. ncbi Serum glucose concentration and ACP1 genotype in healthy adult subjects
    Umberto Iannaccone
    Division of Occupational Health Medicine, Department of Biopathology and Imaging Diagnostics, School of Medicine, University of Rome Tor Vergata, 00123 Rome Italy
    Metabolism 54:891-4. 2005
    Acid phosphatase locus 1 (ACP 1 ) or cytosolic low molecular weight protein tyrosine phosphatase is a polymorphic enzyme that can hydrolyze phosphotyrosine-containing peptides of the human insulin receptor and of band 3 protein...
  19. ncbi Repeated spontaneous abortion. Cooperative effects of ADA and ACP1 genetic polymorphisms
    M Nicotra
    Institute of Gynaecology, Perinatology and Child Disease, University of Rome La Sapienza, School of Medicine, Rome, Italy
    Am J Reprod Immunol 58:1-10. 2007
    In consideration of the effect of adenosine deaminase (ADA) and ACP1 (a low-molecular-weight protein tyrosine phosphatase) on T-cell receptor activity, we have analysed the joint distribution of these polymorphisms in a sample of women ..
  20. doi ACP1 genetic polymorphism and coronary artery disease: an association study
    M Banci
    Department of Cardiology, Valmontone Hospital, Rome, Italy
    Cardiology 113:236-42. 2009
    ..of atherosclerosis, we have investigated a possible association between coronary artery disease (CAD) and the acid phosphatase locus 1 (ACP1) genetic polymorphism, which has previously been found to be associated with immune disorders.
  21. doi ACP1 genotype, glutathione reductase activity, and riboflavin uptake affect cardiovascular risk in the obese
    Nadja Apelt
    Laboratório de Genética e Centro de Metabolismo e Endocrinologia, FML, Genetic Laboratory and Centre for Metabolism and Endocrinology, Medical Faculty, Lisbon University, Portugal
    Metabolism 58:1415-23. 2009
    Erythrocyte acid phosphatase (ACP locus 1), also known as low-molecular-weight protein tyrosine phosphatase, has previously been associated to glycemia, dyslipidemia, and obesity...
  22. ncbi Galpha(i2) enhances insulin signaling via suppression of protein-tyrosine phosphatase 1B
    J Tao
    Department of Molecular Pharmacology, University Medical Center, State University of New York, Stony Brook, New York 11794-8651, USA
    J Biol Chem 276:39705-12. 2001
    ..These data provide the first molecular basis for the interplay between Galpha(i2) and insulin signaling, i.e. activation of Galpha(i2) can suppress both the expression and activity of PTP1B in insulin-sensitive tissues...
  23. ncbi Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation
    B A Binstadt
    Department of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Immunity 5:629-38. 1996
    ..ligation requires the phosphotyrosine-dependent association of KIR with the cytoplasmic SH2-containing protein tyrosine phosphatase SHP-1...
  24. ncbi Expression, purification and kinetic behaviour of fission yeast low M(r) protein-tyrosine phosphatase
    A Modesti
    Dipartimento di Scienze Biochimiche, Universita di Firenze, Italy
    FEBS Lett 375:235-8. 1995
    ..These differing kinetic characteristics are mainly due to the sequence 45-56 that is spatially close to the active site pocket...
  25. ncbi Complex-type asparagine-linked oligosaccharides on phosphacan and protein-tyrosine phosphatase-zeta/beta mediate their binding to neural cell adhesion molecules and tenascin
    P Milev
    Department of Pharmacology, New York University Medical Center, New York 10016, USA
    J Biol Chem 270:24650-3. 1995
    ....
  26. ncbi Characterization of protein tyrosine phosphatase activity in rat liver microsomes: suppressive effect of endogenous regucalcin in transgenic rats
    Yuko Fukaya
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka, Japan
    Int J Mol Med 14:427-32. 2004
    ..with that of the enzyme activity toward phosphoserine and phosphothreonine, indicating the existence of protein tyrosine phosphatase. Protein phosphatase activity toward three phosphoaminoacids was significantly enhanced by the addition ..
  27. pmc Interactions of the chondroitin sulfate proteoglycan phosphacan, the extracellular domain of a receptor-type protein tyrosine phosphatase, with neurons, glia, and neural cell adhesion molecules
    P Milev
    Department of Pharmacology, New York University Medical Center, New York 10016
    J Cell Biol 127:1703-15. 1994
    ..glial cells in the central nervous system, and represents the extracellular domain of a receptor-type protein tyrosine phosphatase (RPTP zeta/beta)...
  28. pmc The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development
    M J Gutch
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Genes Dev 12:571-85. 1998
    ..We isolated a recessive ptp-2 loss-of-function allele, op194, that lacks the conserved protein tyrosine phosphatase catalytic domain by screening for transposon-mediated deletion mutations...
  29. pmc Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation
    A Oganesian
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 100:7563-8. 2003
    b>Protein tyrosine phosphatase RQ (PTPRQ) was initially identified as a protein tyrosine phosphatase (PTPase)-like protein that is upregulated in a model of renal injury...
  30. ncbi Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells
    S Avraham
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Gene 204:5-16. 1997
    ..A novel PTP, termed protein tyrosine phosphatase receptor omicron (PTPRO), which is related to the homotypically adhering kappa, mu and PCP-2 receptor-..
  31. ncbi Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein
    B J Goldstein
    Dorrance H Hamilton Research Laboratories, Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 275:4283-9. 2000
    ....
  32. pmc Regulation of interleukin-3-induced substrate phosphorylation and cell survival by SHP-2 (Src-homology protein tyrosine phosphatase 2)
    Helen Wheadon
    Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK
    Biochem J 376:147-57. 2003
    The cytosolic SHP-2 (Src homology protein tyrosine phosphatase 2) has previously been implicated in IL-3 (interleukin-3) signalling [Bone, Dechert, Jirik, Schrader and Welham (1997) J. Biol. Chem...
  33. ncbi Protein-tyrosine phosphatase, nonreceptor type 11 mutation analysis and clinical assessment in 45 patients with Noonan syndrome
    Rie Yoshida
    Department of Pediatrics, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Clin Endocrinol Metab 89:3359-64. 2004
    ....
  34. doi A protein tyrosine phosphatase-like inositol polyphosphatase from Selenomonas ruminantium subsp. lactilytica has specificity for the 5-phosphate of myo-inositol hexakisphosphate
    Aaron A Puhl
    Department of Biological Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada T1K 3M4
    Int J Biochem Cell Biol 40:2053-64. 2008
    ..A novel protein tyrosine phosphatase (PTP)-like inositol polyphosphatase (IPPase) gene has been cloned from Selenomonas ruminantium subsp...
  35. pmc Receptor-type protein tyrosine phosphatase beta (RPTP-beta) directly dephosphorylates and regulates hepatocyte growth factor receptor (HGFR/Met) function
    Yiru Xu
    Department of Dermatology, University of Michigan Medica School, Ann Arbor, MI 48109 5609, USA
    J Biol Chem 286:15980-8. 2011
    ..of specific proteins is finely tuned by the dynamic balance between protein tyrosine kinase and protein tyrosine phosphatase activities...
  36. ncbi Abnormal splicing of SHP-1 protein tyrosine phosphatase in human T cells. Implications for lymphomagenesis
    Xue Zhong Ma
    Department of Medicine and Institute of Medical Science, University of Toronto, 67 College Street, Toronto M5G 2M1, Ontario, Canada
    Exp Hematol 31:131-42. 2003
    SHP-1 protein tyrosine phosphatase has been implicated in suppressing B-lymphocyte and myeloid cell malignancies; however, there are little data on this role of SHP-1 in T-lymphocyte malignancies...
  37. ncbi Self-complementary adeno-associated virus 2 (AAV)-T cell protein tyrosine phosphatase vectors as helper viruses to improve transduction efficiency of conventional single-stranded AAV vectors in vitro and in vivo
    Li Zhong
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis 46202, USA
    Mol Ther 10:950-7. 2004
    ..We have documented that dephosphorylation of FKBP52 at tyrosine residues by the cellular T cell protein tyrosine phosphatase (TC-PTP) enhances AAV-mediated transduction in primary murine hematopoietic cells from TC-PTP-..
  38. pmc Associations of a PTPN11 G/A polymorphism at intron 3 with Helicobactor pylori seropositivity, gastric atrophy and gastric cancer in Japanese
    Asahi Hishida
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan
    BMC Gastroenterol 9:51. 2009
    ..pylori infection in the presence of SHP-2 (src homology 2 domain-containing protein tyrosine phosphatase-2)...
  39. pmc Chimeric design, synthesis, and biological assays of a new nonpeptide insulin-mimetic vanadium compound to inhibit protein tyrosine phosphatase 1B
    Thomas Scior
    Facultad de Ciencias Quimicas, Universidad Autonoma de Puebla, Pue, Puebla, Mexico
    Drug Des Devel Ther 4:231-42. 2010
    ..new vanadium coordination compound, called TSAG0101, was computationally designed to inhibit the enzyme protein tyrosine phosphatase 1B (PTP1B)...
  40. ncbi Cloning and characterization of a Saccharomyces cerevisiae gene encoding the low molecular weight protein-tyrosine phosphatase
    K Ostanin
    Department of Chemistry, Purdue University, West Lafayette, Indiana 47907 1393, USA
    J Biol Chem 270:18491-9. 1995
    ..cerevisiae...
  41. doi Protein tyrosine phosphatase-alpha complexes with the IGF-I receptor and undergoes IGF-I-stimulated tyrosine phosphorylation that mediates cell migration
    Shirley C Chen
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Physiol Cell Physiol 297:C133-9. 2009
    b>Protein tyrosine phosphatase-alpha (PTPalpha) is a widely expressed receptor-type phosphatase that functions in multiple signaling systems...
  42. ncbi Crystal structure of the Yersinia protein-tyrosine phosphatase YopH complexed with a specific small molecule inhibitor
    Jin Peng Sun
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 278:33392-9. 2003
    ..Because the phosphatase activity of the Yersinia protein tyrosine phosphatase, YopH, is essential for virulence in the Yersinia pathogen, potent and selective YopH inhibitors are ..
  43. doi Formation of smooth muscle alpha actin filaments in CD34+ bone marrow cells on arterial elastic laminae: potential role of SH2 domain-containing protein tyrosine phosphatase-1
    Shu Q Liu
    Biomedical Engineering Department, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 3107, United States
    Matrix Biol 27:282-94. 2008
    ..regulating the formation of SM alpha actin filaments in mouse CD34+ bone marrow cells and the role of a protein tyrosine phosphatase, SH2 domain-containing protein tyrosine phosphatase (SHP)-1, in the mediation of this process...
  44. ncbi Immunochemical characterization of human red cell acid phosphatase isozymes
    J Dissing
    Institute of Forensic Genetics, University of Copenhagen, Denmark
    Biochem Genet 25:901-18. 1987
    An immunological study was performed on human red cell acid phosphatase (ACP1) isozymes encoded by different alleles, each of which is expressed as an electrophoretically fast (f) isozyme and a slow (s) isozyme...
  45. pmc Protein tyrosine phosphatase PTP-S binds to the juxtamembrane region of the hepatocyte growth factor receptor Met
    E Villa-Moruzzi
    Department of Experimental Pathology, University of Pisa, Via Roma 55, 56126 Pisa, Italy
    Biochem J 336:235-9. 1998
    We reported previously that a protein tyrosine phosphatase (PTP) activity is associated with the immunoprecipitated hepatocyte growth factor (HGF) receptor, also known as Met...
  46. pmc Receptor-like protein tyrosine phosphatase alpha homodimerizes on the cell surface
    G Jiang
    Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Mol Cell Biol 20:5917-29. 2000
    ..Such RPTPalpha dimers could be activated by extracellular ligands or intracellular binding proteins that induce monomerization or by intracellular signaling events that induce an open conformation of the dimer...
  47. ncbi Detection of autoantibodies to protein tyrosine phosphatase-like protein IA-2 with a novel time-resolved fluorimetric assay
    Annette Westerlund-Karlsson
    Department of Biochemistry and Pharmacy, Abo Akademi University, FIN 20521 Turku, Finland
    Clin Chem 49:916-23. 2003
    ..to pancreatic glutamic acid decarboxylase (GAD65; the 65-kDa isoform of glutamic acid decarboxylase), protein tyrosine phosphatase-like protein IA-2, and insulin can be used as predictive markers of type 1 diabetes...
  48. ncbi Expression of a structurally unique osteoclastic protein-tyrosine phosphatase is driven by an alternative intronic, cell type-specific promoter
    Mehran Amoui
    Musculoskeletal Disease Center, Jerry L Pettis Memorial Veterans Affairs Medical Center, Loma Linda University, Loma Linda, California 92357, USA
    J Biol Chem 278:44273-80. 2003
    ..This GLEPP1/PTP-oc gene system is one of the very few systems in which two important tissue-specific enzymes are derived from the same gene by the use of alternative intronic promoters...
  49. ncbi Receptor-type protein-tyrosine phosphatase-kappa regulates epidermal growth factor receptor function
    Yiru Xu
    Department of Dermatology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 280:42694-700. 2005
    ..Taken together, the above data indicate that RPTP-kappa is a key regulator of EGFR tyrosine phosphorylation and function in human keratinocytes...
  50. ncbi Contact inhibition of hepatocyte growth regulated by functional association of the c-Met/hepatocyte growth factor receptor and LAR protein-tyrosine phosphatase
    Mitsuru Machide
    Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Biol Chem 281:8765-72. 2006
    ..Thus functional association of LAR and c-Met underlies the inhibition of c-Met-mediated mitogenic signaling through the dephosphorylation of c-Met, which specifically occurs under the confluent condition...
  51. ncbi Lack of pharmacokinetic interaction for ISIS 113715, a 2'-0-methoxyethyl modified antisense oligonucleotide targeting protein tyrosine phosphatase 1B messenger RNA, with oral antidiabetic compounds metformin, glipizide or rosiglitazone
    Richard S Geary
    Isis Pharmaceuticals, Inc, Carlsbad, California 92008, USA
    Clin Pharmacokinet 45:789-801. 2006
    ISIS 113715 is a 20-mer phosphorothioate antisense oligonucleotide (ASO) that is complementary to the protein tyrosine phosphatase 1B (PTP-1B) messenger RNA and subsequently reduces translation of the PTP-1B protein, a negative regulator ..
  52. ncbi The leukocyte common antigen-related protein tyrosine phosphatase receptor regulates regenerative neurite outgrowth in vivo
    Y Xie
    Department of Neurology, University of California, San Francisco Veteran s Administration Medical Center, San Francisco, California 94121, USA
    J Neurosci 21:5130-8. 2001
    Drosophila and leech models of nervous system development demonstrate that protein tyrosine phosphatase (PTP) receptors regulate developmental neurite outgrowth...
  53. ncbi Molecular cloning of POEM: a novel adhesion molecule that interacts with alpha8beta1 integrin
    N Morimura
    Research Institute for Biological Sciences, Science University of Tokyo, Yamazaki 2669, Noda, Chiba 278 0022, Japan
    J Biol Chem 276:42172-81. 2001
    ..These results suggest that POEM is a novel ligand for alpha(8)beta(1) integrin and that POEM may be involved in the development and function of various tissues, such as kidney, bone, muscles, and endocrine organs...
  54. ncbi PTPN11 (protein tyrosine phosphatase, nonreceptor type 11) mutations and response to growth hormone therapy in children with Noonan syndrome
    Lize V Ferreira
    Hospital das Clinicas, Labaratorio de Hormonios, Avenue Dr Eneas de Carvalho Aguiar 155 PAMB, 2 Andar Bloco 6, 05403 900 Sao Paulo, Brazil
    J Clin Endocrinol Metab 90:5156-60. 2005
    The cause of growth impairment in Noonan syndrome (NS) remains unclear. Mutations in PTPN11 (protein tyrosine phosphatase, nonreceptor type 11) that codify constitutively activated Src homology protein tyrosine phosphatase-2 tyrosine ..
  55. ncbi The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins
    Angela Iervolino
    Naples Oncogenomic Center Centro di Ricerca per l Ingegneria Genetica, Biotecnologie Avanzate, Italy
    Cancer Res 66:6280-7. 2006
    ..We showed previously that the expression of the receptor-type protein tyrosine phosphatase J (PTPRJ) is suppressed in neoplastically transformed follicular thyroid cells...
  56. doi Effect of ionic strength and oxidation on the P-loop conformation of the protein tyrosine phosphatase-like phytase, PhyAsr
    Robert J Gruninger
    Department of Chemistry and Biochemistry, University of Lethbridge, Canada
    FEBS J 275:3783-92. 2008
    The protein tyrosine phosphatase (PTP)-like phytase, PhyAsr, from Selenomonas ruminantium is a novel member of the PTP superfamily, and the only described member that hydrolyzes myo-inositol-1,2,3,4,5,6-hexakisphosphate...
  57. pmc Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts
    A Angers-Loustau
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada H3G 1Y6
    J Cell Biol 144:1019-31. 1999
    In this article, we show that, in transfected COS-1 cells, protein tyrosine phosphatase (PTP)-PEST translocates to the membrane periphery following stimulation by the extracellular matrix protein fibronectin...
  58. ncbi Effects of adenovirus-mediated liver-selective overexpression of protein tyrosine phosphatase-1b on insulin sensitivity in vivo
    J Wang
    University of Tennessee, Memphis, TN, USA
    Diabetes Obes Metab 3:367-80. 2001
    b>Protein tyrosine phosphatase-1B (PTP-1B) is an intracellular PTP known to dephosphorylate and inactivate upstream tyrosine phosphoproteins in the insulin signalling cascade...
  59. doi Integrin alpha(v)beta(3) is a pleiotrophin receptor required for pleiotrophin-induced endothelial cell migration through receptor protein tyrosine phosphatase beta/zeta
    Constantinos Mikelis
    Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, GR 26504, Greece
    FASEB J 23:1459-69. 2009
    ..growth factor pleiotrophin (PTN) induces migration of endothelial cells through binding to its receptor protein tyrosine phosphatase beta/zeta (RPTPbeta/zeta)...
  60. ncbi PTP NE-6: a brain-enriched receptor-type protein tyrosine phosphatase with a divergent catalytic domain
    L R Fitzgerald
    University of Maryland at Baltimore, Department of Anatomy and Neurobiology, U S A
    J Neurochem 68:1820-9. 1997
    A receptor-type protein tyrosine phosphatase, PTP NE-6, was identified from rat olfactory epithelial cDNA and cloned from a rat brain cDNA library...
  61. doi Protein tyrosine phosphatase SHP-2: a proto-oncogene product that promotes Ras activation
    Takashi Matozaki
    Laboratory of Biosignal Sciences, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan
    Cancer Sci 100:1786-93. 2009
    SHP-2 is a cytoplasmic protein tyrosine phosphatase (PTP) that contains two Src homology 2 (SH2) domains...
  62. ncbi Effect of nitration on protein tyrosine phosphatase and protein phosphatase activity in neuronal cell membranes of newborn piglets
    Carlos J Lopez
    Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA, USA
    Neurosci Lett 386:78-81. 2005
    b>Protein tyrosine phosphatase predominantly determines the status of protein tyrosine kinase-dependent phosphorylation of specific proteins and controls the survival and death of neurons...
  63. pmc Multi-site phosphorylation of the protein tyrosine phosphatase, PTP1B: identification of cell cycle regulated and phorbol ester stimulated sites of phosphorylation
    A J Flint
    Cold Spring Harbor Laboratory, NY 11724
    EMBO J 12:1937-46. 1993
    The non-transmembrane protein tyrosine phosphatase, PTP1B, comprises 435 amino acids, of which the C-terminal 114 residues have been implicated in controlling both localization and function of this enzyme...
  64. ncbi Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes
    Agueda Gonzalez-Rodriguez
    Instituto de Investigaciones Biomédicas Alberto Sols Centro mixto Consejo Superior de Investigaciones Cientificas Universidad Autónoma, c Arturo Duperier 4, 28029 Madrid, Spain
    Endocrinology 148:594-608. 2007
    b>Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin signaling and a therapeutic target for type 2 diabetes...
  65. doi SH2 domain-containing phosphatase-2 protein-tyrosine phosphatase promotes Fc epsilon RI-induced activation of Fyn and Erk pathways leading to TNF alpha release from bone marrow-derived mast cells
    Victor A McPherson
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada
    J Immunol 183:4940-7. 2009
    ..Overall, our study identifies SHP2 as a positive effector of Fc(epsilon)RI-induced activation of Fyn/Grb2-associated binder 2/Akt and Ras/Erk pathways leading to TNF-alpha release from mast cells...
  66. doi Pharmacological profiles of a novel protein tyrosine phosphatase 1B inhibitor, JTT-551
    S Fukuda
    Japan Tobacco, Inc, Central Pharmaceutical Research Institute, 1 1, Murasaki cho, Takatsuki, Osaka 569 1125, Japan
    Diabetes Obes Metab 12:299-306. 2010
    b>Protein tyrosine phosphatase 1B (PTP1B), a negative regulator of insulin signalling, is a novel therapeutic target for type 2 diabetes mellitus...
  67. pmc Serine dephosphorylation of receptor protein tyrosine phosphatase alpha in mitosis induces Src binding and activation
    Andrei M Vacaru
    Hubrecht Institute KNAW and University Medical Center, Utrecht, Netherlands
    Mol Cell Biol 30:2850-61. 2010
    Receptor protein tyrosine phosphatase alpha (RPTPalpha) is the mitotic activator of the protein tyrosine kinase Src. RPTPalpha serine hyperphosphorylation was proposed to mediate mitotic activation of Src...
  68. doi Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn
    Yoji Murata
    Laboratory of Biosignal Sciences, Institute for Molecular and Cellular Regulation, Gunma University, 3 39 15 Showa Machi, Maebashi, Gunma 371 8512, Japan
    Genes Cells 15:513-24. 2010
    ..Stomach cancer-associated protein tyrosine phosphatase-1 (SAP-1), as well as protein tyrosine phosphatase receptor type O (PTPRO) and vascular endothelial-..
  69. ncbi Protein tyrosine phosphatase PRL-3 in malignant cells and endothelial cells: expression and function
    Cecile Rouleau
    Genzyme Corp, 1 Mountain Road, Framingham, MA 01701, USA
    Mol Cancer Ther 5:219-29. 2006
    b>Protein tyrosine phosphatase PRL-3 mRNA was found highly expressed in colon cancer endothelium and metastases. We sought to associate a function with PRL-3 expression in both endothelial cells and malignant cells using in vitro models...
  70. pmc A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain
    W Hendriks
    Department of Cell Biology and Histology, University of Nijmegen, The Netherlands
    Biochem J 305:499-504. 1995
    ..This suggests a role for PTP-SL in cell-cell signalling processes in the brain...
  71. ncbi Brain-specific receptor-type protein-tyrosine phosphatase RPTP beta is a chondroitin sulfate proteoglycan in vivo
    K Shitara
    Cancer Research Center, La Jolla Cancer Research Foundation, California 92037
    J Biol Chem 269:20189-93. 1994
    ..These data establish that RPTP beta is expressed constitutively as a chondroitin sulfate proteoglycan in the brain, and suggest that chondroitin sulfates may be an essential component for the physiological function of RPTP beta in vivo...
  72. ncbi Properties of pervanadate and permolybdate. Connexin43, phosphatase inhibition, and thiol reactivity as model systems
    S O Mikalsen
    Department of Environmental and Occupational Cancer, Institute for Cancer Research, The Norwegian Radium Hospital, N 0310 Oslo, Norway
    J Biol Chem 273:10036-45. 1998
    ..Mathematical modeling of the thiol reactivity suggested that monoperoxovanadate at maximum could possess 20% of the biological activity of diperoxovanadate...
  73. ncbi The B-cell transmembrane protein CD72 binds to and is an in vivo substrate of the protein tyrosine phosphatase SHP-1
    Y Wu
    Program in Molecular Biology, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Curr Biol 8:1009-17. 1998
    ..The protein tyrosine phosphatase SHP-1 is known to regulate the strength of BCR signaling...
  74. ncbi GABA(A) receptor modulation in rat cerebellum granule cells
    A Cupello
    Centro di Neurofisiologia Cerebrale, CNR, Genova, Italy
    Receptors Channels 7:151-71. 2000
    ..of N-methyl-D-aspartate (NMDA) receptors via calcineurin mediated dephosphorylation/activation of protein tyrosine phosphatase and concomitant production of nitric oxide and PKG activation...
  75. ncbi Laforin is a cell membrane and endoplasmic reticulum-associated protein tyrosine phosphatase
    B A Minassian
    Department of Paediatrics, The Hospital for Sick Children, The University of Toronto, Ontario, Canada
    Ann Neurol 49:271-5. 2001
    ..in LD, localizes at the plasma membrane and the endoplasmic reticulum and that it is a functional protein tyrosine phosphatase. The significance of these findings in the epilepsy of LD and in the origin and characteristic ..
  76. ncbi Color-pattern modifications and speciation in butterflies of the genus Vanessa and its related genera Cynthia and Bassaris
    Joji M Otaki
    Department of Biological Sciences, Kanagawa University, Tsuchiya, Hiratsuka, Kanagawa, Japan
    Zoolog Sci 21:967-76. 2004
    ..This evolutionary mechanism may probably be shared more widely in Lepidoptera, although this would not be a sole determinant for the color-pattern development and evolution...
  77. ncbi Localization of Src homology 2 domain-containing phosphatase 1 (SHP-1) to lipid rafts in T lymphocytes: functional implications and a role for the SHP-1 carboxyl terminus
    Vicki C J Fawcett
    Department of Microbiology and the Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 174:2849-59. 2005
    The protein tyrosine phosphatase Src homology 2 domain-containing phosphatase 1 (SHP-1) has previously been shown to be a negative regulator of signaling mediated via the TCR...
  78. pmc Essential role of Shp2-binding sites on FRS2alpha for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells
    S Yamamoto
    Division of Genetics, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 102:15983-8. 2005
    ..mediates many of its pleiotropic cellular responses by recruiting the adaptor protein Grb2 and the protein tyrosine phosphatase Shp2 upon ligand stimulation...
  79. ncbi Enzyme occupancy measurement of intracellular protein tyrosine phosphatase 1B using photoaffinity probes
    Kathryn Skorey
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Que, Canada H9H 3L1
    Anal Biochem 349:49-61. 2006
    b>Protein tyrosine phosphatase 1B (PTP1B) is believed to be one of the enzymes involved in down-regulating the insulin receptor and is a drug target for the treatment of type II diabetes...
  80. ncbi Genetic ablation of Ptprj, a mouse cancer susceptibility gene, results in normal growth and development and does not predispose to spontaneous tumorigenesis
    Francesco Trapasso
    Dipartimento di Medicina Sperimentale e Clinica, Universita Magna Graecia di Catanzaro, Campus Germaneto, Catanzaro, Italy
    DNA Cell Biol 25:376-82. 2006
    Ptprj is a ubiquitously expressed murine gene encoding a receptor-type protein tyrosine phosphatase, which has recently been proposed as a candidate gene on the locus Scc1 for colon cancer susceptibility...
  81. doi PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome
    Barbara Schormair
    Institute of Human Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg 85764, Germany
    Nat Genet 40:946-8. 2008
    ..91 x 10(-10), odds ratio (OR) = 1.44; rs1975197, P(nominal/lambda corrected) = 5.81 x 10(-9), OR = 1.31). This work identifies PTPRD as the fourth genome-wide significant locus for RLS...
  82. pmc Glucose-oxidized low-density lipoproteins enhance insulin-like growth factor I-stimulated smooth muscle cell proliferation by inhibiting integrin-associated protein cleavage
    Lee B Allen
    Department of Medicine, Division of Endocrinology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7170, USA
    Endocrinology 150:1321-9. 2009
    ..of IAP leading to increase in the basal association between IAP and Src homology 2 domain-containing protein tyrosine phosphatase substrate-1, which is required for IGF-I-stimulated proliferation...
  83. doi Carboxypeptidase-H autoantibodies differentiate a more latent subset of autoimmune diabetes from phenotypic type 2 diabetes among Chinese adults
    L Yang
    Diabetes Center, Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China
    Ann N Y Acad Sci 1150:263-6. 2008
    ..CPH-Ab(+) T2D patients also underwent testing for insulinoma protein tyrosine phosphatase (IA-2A). Clinical features were compared among CPH-Ab(+), GAD-Ab(+), and Ab(-) T2D patients...
  84. doi Expression of CD45 isoforms correlates with differential proliferative responses of peripheral CD4+ and CD8+ T cells
    Iwao Seki
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Immunol Lett 129:39-46. 2010
    ..a Jak phosphatase, was expressed on the two T cell populations, those on the CD8(+) T cells have less protein tyrosine phosphatase activity than those on the CD4(+) T cells...
  85. pmc MSP hormonal control of the oocyte MAP kinase cascade and reactive oxygen species signaling
    Youfeng Yang
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Dev Biol 342:96-107. 2010
    ..We propose that secreted MSP domains and Cu/Zn superoxide dismutases function antagonistically to control ROS and MAPK signaling...
  86. doi Dual oxidase 1 induced by Th2 cytokines promotes STAT6 phosphorylation via oxidative inactivation of protein tyrosine phosphatase 1B in human epidermal keratinocytes
    Satoshi Hirakawa
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    J Immunol 186:4762-70. 2011
    ..of DUOX1 in IL-4/IL-13-treated NHEK augments STAT6 phosphorylation via oxidative inactivation of protein tyrosine phosphatase 1B...
  87. doi Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease
    Albert Giralt
    Departament de Biologia Cel lular, Immunologia i Neurociencies, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain
    Hum Mol Genet 20:4232-47. 2011
    ..receptor subunit 1, Ras-guanine nucleotide releasing factor-1 and striatal-enriched protein tyrosine phosphatase, but not cAMP-responsive element binding protein or the microtubule-associated protein tau...
  88. doi Sex differences and genomics in autoimmune diseases
    Shashi Amur
    Office of Clinical Pharmacology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20903, USA
    J Autoimmun 38:J254-65. 2012
    ..For example, genetic polymorphisms in the Protein Tyrosine Phosphatase-22 (PTPN22) gene have reproducibly shown to have association with systemic lupus erythematosus (SLE), ..
  89. doi SHPS-1 and a synthetic peptide representing its ITIM inhibit the MyD88, but not TRIF, pathway of TLR signaling through activation of SHP and PI3K in THP-1 cells
    Eun Ju Kim
    School of Life Sciences and Biotechnology, Kyungpook National University, Daegu 702 701, Korea
    Inflamm Res 62:377-86. 2013
    Src homology 2 domain-containing protein tyrosine phosphatase substrate (SHPS)-1 is known to have regulatory effects on myeloid cells. However, its role in macrophage activation is not clearly understood.
  90. doi Free fatty acids inhibit protein tyrosine phosphatase 1B and activate Akt
    Eisuke Shibata
    Department of Thoracic Oncology, Hyogo College of Medicine, Nishinomiya, Japan
    Cell Physiol Biochem 32:871-9. 2013
    ..Accumulating evidence has suggested that free fatty acids (FFAs) interact with protein kinases and protein phosphatases. The present study examined the effect of FFAs on protein phosphatases and Akt...
  91. pmc Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9
    Bo Mi Hwang
    Departments of Biochemistry, Chonbuk National University Medical School, Jeonju 560 756, Korea
    BMB Rep 46:533-8. 2013
    ..However, BVT948 didn't block TPA-induced AP-1 activation in MCF-7 cells. Our results suggest that the PTP inhibitor blocks breast cancer invasion via suppression of the expression of MMP-9...
  92. doi Bordetella pertussis Adenylate Cyclase Toxin Blocks Induction of Bactericidal Nitric Oxide in Macrophages through cAMP-Dependent Activation of the SHP-1 Phosphatase
    Ondrej Cerny
    Laboratory of Molecular Biology of Bacterial Pathogens, Institute of Microbiology of the ASCR, v v i, Czech Academy of Sciences, 142 20, Prague 4, Czech Republic
    J Immunol 194:4901-13. 2015
    ..cAMP signaling through the protein kinase A (PKA) pathway activates Src homology domain 2 containing protein tyrosine phosphatase (SHP) 1 and suppresses production of bactericidal NO in macrophage cells...
  93. doi miR-601 is a prognostic marker and suppresses cell growth and invasion by targeting PTP4A1 in breast cancer
    Jing Ye Hu
    Department of Basic Medicine, Guiyang College of Traditional Chinese Medicine, Guiyang 550002, People s Republic of China
    Biomed Pharmacother 79:247-53. 2016
    ..Furthermore, protein tyrosine phosphatase type IVA 1 (PTP4A1) was identified as a direct target of miR-601...
  94. ncbi PTP1B promotes aggressiveness of breast cancer cells by regulating PTEN but not EMT
    Xue Liu
    Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, and Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, 400038, China
    Tumour Biol 37:13479-13487. 2016
    ..In this study, we found that protein tyrosine phosphatase 1B (PTP1B) promoted breast cancer metastasis by regulating phosphatase and tensin homolog (PTEN) but ..
  95. ncbi VSL#3 Probiotic Stimulates T-cell Protein Tyrosine Phosphatase-mediated Recovery of IFN-γ-induced Intestinal Epithelial Barrier Defects
    Moorthy Krishnan
    Division of Biomedical Sciences, University of California, Riverside, California and Division of Gastroenterology, University of California, San Diego School of Medicine, La Jolla, California
    Inflamm Bowel Dis 22:2811-2823. 2016
    VSL#3 is a probiotic compound that has been used in the treatment of inflammatory bowel disease. T-cell protein tyrosine phosphatase (TCPTP) is the protein product of the inflammatory bowel disease candidate gene, PTPN2, and we have ..
  96. ncbi Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene
    L D Shultz
    Jackson Laboratory, Bar Harbor, Maine 04609
    Cell 73:1445-54. 1993
    ..These findings provide the first available animal models for a specific protein-tyrosine phosphatase deficiency, thus facilitating determination of the precise role of this signaling molecule in hematopoiesis...
  97. ncbi Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro
    D H Ng
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada
    J Biol Chem 271:1295-300. 1996
    ..In addition, this interaction occurred in the absence of any detectable tyrosine phosphorylation on CD45, suggesting a nonconventional SH2 domain interaction...
  98. ncbi Expression of protein tyrosine phosphatase PTP-RL10 and its isoform in the mouse testis
    H Tokuchi
    Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, Japan
    Int J Urol 6:572-7. 1999
    The cytoplasmic-type protein tyrosine phosphatase PTP-RL10/PTPD1/PTP2E contains an ezrin-like domain and associates with the c-Src protein tyrosine kinase...
  99. ncbi Genomic characterization of the human and mouse protein tyrosine phosphatase-1B genes
    P A Forsell
    Department of Biochemistry and Molecular Biology, Merck Frosst Center for Therapeutic Research, Kirkland, Quebec H9H 3L1, Canada
    Gene 260:145-53. 2000
    PTP-1B is a ubiquitously expressed intracellular protein tyrosine phosphatase (PTP) that has been implicated in the negative regulation of insulin signaling...
  100. ncbi An ACTH-activated protein tyrosine phosphatase (PTP) is modulated by PKA-mediated phosphorylation
    C Paz
    Dept of Biochemistry, School of Medicine, University of Buenos Aires, Argentina
    Endocr Res 26:609-14. 2000
    ....
  101. ncbi The YRD motif is a major determinant of substrate and inhibitor specificity in T-cell protein-tyrosine phosphatase
    E Asante-Appiah
    Department of Biochemistry and Molecular Biology, Merck Frosst Center for Therapeutic Research, Pointe Claire Dorval H9R 4P8, Canada
    J Biol Chem 276:26036-43. 2001
    ..These results suggest that Arg(49) and Asp(50) may be targeted for the design of potent and selective inhibitors of TCPTP and PTP1B...

Research Grants80

  1. Osteoclastic Protein-Tyrosine Phosphatase and Resorption
    Kin Hing William Lau; Fiscal Year: 2013
    ..This project may allow disclose novel targets for development of more effective anti-resorptive therapies for osteoporosis and related disease. Thus, this project is highly relevant to the VA patient care mission. ..
  2. FAWAZ GEORGE HAJ; Fiscal Year: 2015
    ..Therefore, understanding how adipose PTP1B acts is vital for its evaluation of use as a target for therapeutic intervention. ..
  3. Zhong Yin Zhang; Fiscal Year: 2014
    ..In addition, potent and selective SHP2 inhibitors will also serve as powerful research tools to delineate the function of SHP2 in normal physiology and to elucidate the events underlying SHP2-evoked transformation. ..
  4. Dae Joon Kim; Fiscal Year: 2016
    ..However, recently we have discovered that T-cell protein tyrosine phosphatase (TC-PTP) is activated following UVB or chemical exposure...
  5. Phosphatase Regulation of Olfactory Bulb Mitral Cell Activity
    Melissa Cavallin Johnson; Fiscal Year: 2011
    ..The specific aims of this proposal are to determine the role of a protein tyrosine phosphatase, SHP-2, in the insulin signaling cascade that regulates Kv1.3 activity in the olfactory bulb...
  6. Radhakrishna Rao; Fiscal Year: 2014
    ..of this acetaldehyde-induced disruption of epithelial barrier function involves inhibition of a protein tyrosine phosphatase, PTP1B, tyrosine phosphorylation of junctional proteins, disruption of the interactions among the ..
  7. Mechanisms for the Effects of Hypothalamic PTP1B on Energy Balance
    KARYN JOANNE CATALANO; Fiscal Year: 2010
    ..Leptin undergoes negative regulation by the ubiquitously expressed protein tyrosine phosphatase PTP1B, suggesting that PTP1B may be a useful target for drug therapy in leptin resistance...
  8. Frank A Anania; Fiscal Year: 2016
    ..Preliminary data reveal adiponectin prevents phosphorylation of FAK by the protein tyrosine phosphatase, SHP-2;and adiponectin prevents FA assembly both in vitro and in vivo...
  9. Novel anti-toxin compounds against Yersinia infections
    Maurizio Pellecchia; Fiscal Year: 2010
    ..Yersinae use a number of toxins to evade the immune system one of which is the protein tyrosine phosphatase YopH...
  10. Gloria Lee; Fiscal Year: 2016
    ..Microtubule binding was not involved. In addition, we found that tau associated with the protein tyrosine phosphatase SHP2 in an NGF-dependent manner...
  11. Zhong Yin Zhang; Fiscal Year: 2016
    ..This competitive renewal focuses on SHP2 (Src homology 2 (SH2)-domain containing protein tyrosine phosphatase-2), which is the first bona fide oncoprotein identified in the PTP superfamily...
  12. Inhibition of the Interferon Response by West Nile Virus
    Christoph Seeger; Fiscal Year: 2010
    ..the IFNa receptor complex or if they operate indirectly by activating a cellular antagonist, such as a protein tyrosine phosphatase or other known negative regulators of the IFN response...
  13. CHARLES B GOODWIN; Fiscal Year: 2014
    ..of the Ras signaling pathway, including activating mutations in PTPN11, which encodes the protein tyrosine phosphatase, Shp2...
  14. Targeting bacterial phosphatases for novel anti-bacterial agents.
    Maurizio Pellecchia; Fiscal Year: 2013
    ..and Yersinia enterocolitica use a number of toxins to evade the immune system one of which is the protein tyrosine phosphatase YopH...
  15. NATHAN JAMES LANNING; Fiscal Year: 2014
    ..In a screen to identify genes that regulate metabolism in cancer cells, protein tyrosine phosphatase, mitochondrial 1 (PTPMT1) was found to push cells towards a cancer metabolic program by inhibiting ..
  16. Nicholas K Tonks; Fiscal Year: 2016
    ..long-term objectives of the project are to characterize the structure, regulation and function of the protein tyrosine phosphatase (PTP) family of enzymes...
  17. NEUROMODULATION OF THE ANTIBODY RESPONSE
    Virginia M Sanders; Fiscal Year: 2012
    ..affecting class switch recombination (CSR), through a mechanism that appears to inactivate Hematopoetic protein tyrosine phosphatase (HePTP) and enhance p38 MAPK phosphorylation to mediate an increase in ADAM10, which cleaves membrane ..
  18. CAROLYN ANN WORBY; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Members of the protein tyrosine phosphatase (PTP) super family contain the highly conserved active site motif, Cys-x5-Arg (Cx5R), and are key mediators of a variety of cellular processes including ..
  19. Nicholas K Tonks; Fiscal Year: 2016
    ..this project are to characterize the structure, regulation and physiological function of members of the protein tyrosine phosphatase (PTP) family of enzymes...
  20. Anton M Bennett; Fiscal Year: 2015
    ..a gain-of-function mutation in the human PTPN11 gene which encodes for the SH2 domain-containing protein tyrosine phosphatase, SHP-2...
  21. T1D:Investigating the Gut Microbiome, Urinary Proteome and Metabolome
    Ramana Madupu; Fiscal Year: 2011
    ..Genetic susceptibility traits for T1D are becoming more numerous, including loci for HLA, insulin, protein tyrosine phosphatase-22, cytotoxic T-lymphocyte-associated protein 4, the interleukin-2 receptor and C- type lectin...
  22. STEP inhibitors for intervention in Alzheimer's Disease
    Lutz Tautz; Fiscal Year: 2012
    ..STriatal-Enriched Phosphatase (STEP) is a brain-specific protein tyrosine phosphatase that is highly expressed in regions where consolidation of memory occurs and regulates the ..
  23. Regulation of energy metabolism by an osteoblast-specific gene
    Gerard Karsenty; Fiscal Year: 2010
    ..Esp encodes a protein tyrosine phosphatase expressed in osteoblasts and in Sertoli cells of the testis...
  24. Metabolic Determinants of Cardiovascular Dysfunction in Obesity
    David W Stepp; Fiscal Year: 2013
    ..application, we have generated a novel mouse model in which an insulin receptor desensitizing gene, protein tyrosine phosphatase 1B (PTP1B) is deleted from obese mice...
  25. Small molecule inhibitors of LMPTP: an obesity drug target
    Nunzio Bottini; Fiscal Year: 2013
    ..This grant focuses on a tyrosine phosphatase called the low molecular weight protein tyrosine phosphatase (LMPTP), encoded by the Acp1 gene...
  26. Ilaria Rebay; Fiscal Year: 2016
    ..Specifically Eyes absent (Eya), through its unusual dual functionality as transcription factor and protein tyrosine phosphatase (PTP), has the potential both to respond to upstream signaling inputs by directing downstream patterns ..
  27. Phosphoinositide Phosphatases
    Jack E Dixon; Fiscal Year: 2013
    The protein tyrosine phosphatase superfamily, all of which contain a highly conserved active site motif, Cys- X5-Arg (CX5R) are key mediators of a wide variety of cellular processes, including growth, metabolism, differentiation, motility,..
  28. Samuel Bouyain; Fiscal Year: 2014
    ..this application, we propose to determine the structural basis for the interactions between a receptor protein tyrosine phosphatase called PTPRZ and two of its extracellular binding partners...
  29. Regulation of Proximal Tubule Transport
    Walter F Boron; Fiscal Year: 2013
    ..g., ErbB1). We were intrigued to learn of an orphaned receptor protein tyrosine phosphatase (RPTP3) with a putative extracellular ligand binding domains that strongly resembles carbonic anhydrase ..
  30. Gadiparthi N Rao; Fiscal Year: 2016
    ..that thrombin activates GRB2-associated binding protein 1 (Gab1) and Src homology 2- containing protein tyrosine phosphatase (Shp2), whose stimulation is otherwise expected in response to EGFR activation by its true ligand, EGF, ..
  31. Christopher D Kontos; Fiscal Year: 2014
    ..In addition to Ang-2, Tie2 is negatively regulated by vascular endothelial protein tyrosine phosphatase (VE-PTP)...
  32. Samson T Jacob; Fiscal Year: 2016
    ..In the last granting period, we showed that the gene encoding protein tyrosine phosphatase O (PTPRO) is methylated and silenced in preneoplastic nodules and primary hepatomas induced in a rat ..
  33. Patrick S Moore; Fiscal Year: 2015
    ..One cellular integration site has been defined as the receptor-type protein tyrosine phosphatase-gamma (PTPRG) intron 1. MCPyV also expresses a highly conserved T antigen in tumors...
  34. The role of PTP1B in leptin receptor-dependent and -independent regulation of ene
    Ryan Tsou; Fiscal Year: 2013
    ..Mice with a mutation in the gene encoding leptin (ob/ob) are obese and diabetic. Protein tyrosine phosphatase 1B (PTP1B) has been shown to negatively regulate leptin signaling, and whole body and brain-specific ..
  35. MECHANISMS OF ACTIVATION OF ICE-LIKE CYSTEINE PROTEASES
    Emad S Alnemri; Fiscal Year: 2012
    ..The results of this research will help in the design and discovery of effective therapeutics to treat inflammation associated with aging, auto-inflammatory disease and chronic inflammatory diseases. ..
  36. Jessica E Treisman; Fiscal Year: 2014
    ....
  37. Reuben Kapur; Fiscal Year: 2015
    ..Expression of the Shp2 protein tyrosine phosphatase is consistently elevated in primary leukemia cell specimens from multiple adult acute leukemias ..
  38. Inhibitors of Mycobacterial Protein Tyrosine Phosphatase B (mPTPB) for therapy of
    Francis Burrows; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Inhibitors of Mycobacterial Protein Tyrosine Phosphatase B (mPTPB) for therapy of tuberculosis Aarden Pharmaceuticals Project Summary/Abstract The need exists for a new, breakthrough therapeutic for ..
  39. Impact of genetic variation TLR/CD14 pathways and smoking in RA
    TED RICHARD MIKULS; Fiscal Year: 2011
    ..In addition to genetic polymorphisms of CD14/TLR genes, factors to be studied will include SE and protein tyrosine phosphatase (PTPN22), well characterized risk factors for RA...
  40. Paul T Massa; Fiscal Year: 2015
    ..Further, we have identified that the protein tyrosine phosphatase SHP-1 is a critical regulator of ROS production in oligodendrocytes and oxidative damage to myelin...
  41. Role of PTPN11 Mutations in Myeloid Leukemogenesis
    Kevin M Shannon; Fiscal Year: 2010
    ..PTPN11 is thus the first human oncogene encoding a protein tyrosine phosphatase. Murine Ptpn11 mutant embryos succumb in utero with hematopoietic defects...
  42. PTP mu Supresses Brain Tumor Cell Migration and Dispersal
    Susann M Brady Kalnay; Fiscal Year: 2010
    ..PTPu is a cell surface receptor protein tyrosine phosphatase (RPTP) that is expressed in glial cells...
  43. DNA Methylation & Chromatin Modifications: Mechanisms & Applications in Cancer*
    Samson T Jacob; Fiscal Year: 2010
    ..Project 3 will explore the methylation and suppression of the receptor-type protein tyrosine phosphatase (PTPRO) in CLL, PTPRO promoter methylation and reduced expression in genetic subtypes of CLL, the novel ..
  44. Aristidis Veves; Fiscal Year: 2014
    ..with the diabetes-induced pro-inflammatory state lead to increased expression and activity of protein tyrosine phosphatase 1B (PTP1B) causing reduced growth factor signaling, reduced fibroblast function and impaired wound ..
  45. Nox 4 modulation of NO bioavailability and vascular function
    Siobhan E Craige; Fiscal Year: 2012
    ..modulating eNOS will be characterized and underlying mechanisms probed including Akt, AMP kinase, and protein tyrosine phosphatase 1B...
  46. TIMOTHY AN THY CHAN; Fiscal Year: 2015
    ..Recently, our group has shown that the protein tyrosine phosphatase receptor D, PTPRD, is one of the most commonly inactivated tumor suppressors in GBM...
  47. Shp2 in Osteoclastogenesis and Bone Remodeling
    Wentian Yang; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: We will study the role of protein tyrosine phosphatase Shp2 in osteoclastogenesis and osteoclast functional activation...
  48. Yiru Xu; Fiscal Year: 2015
    ..studies have demonstrated that UV irradiation activates EGFR by oxidative inhibition of receptor-type protein tyrosine phosphatase-kappa (RPTPK), a specific negative regulator of EGFR...
  49. Jie Wu; Fiscal Year: 2016
    ..Consequently, there is near complete lack of knowledge about protein tyrosine phosphatase driver oncogenes in lung adenocarcinoma...
  50. A Genetic Model of NMDA Receptor Function in Cell Death
    Michael Lehmann; Fiscal Year: 2013
    ..As a first result of this research, the protein tyrosine phosphatase Ptpmeg was identified as a putative partner of NMDAR in cell death control...
  51. Structural and functional characterization of the receptor protein tyrosine phosp
    Heidi Erlandsen; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The receptor protein tyrosine phosphatase [unreadable]?? ?(RPTP[unreadable]? ) is a key transmembrane protein that regulates different aspects of ..
  52. PAMELA ANNE MAHER; Fiscal Year: 2014
    ..phenotype by microglia as manifested by an increase in the expression of CD45, a cell surface protein tyrosine phosphatase expressed exclusively by cells of hematopoietic lineages and by inhibition of iNOS induction...
  53. Imaging Enzyme Structure and Dynamics: Specific Function and Functional Diversity
    Hua Deng; Fiscal Year: 2010
    ..The fruits of this work can lead to more thoroughly understanding disease and then to the discovery of new drugs and methods as well as laboratory diagnostic methods. ..
  54. MARIA IRENE KONTARIDIS; Fiscal Year: 2014
    ..Our proposal will determine whether aberrant regulation of the small GTPase RhoA by the protein tyrosine phosphatase Shp2 is directly involved in mediating IDC pathogenesis...
  55. DECLAN MCCOLE; Fiscal Year: 2015
    ..One such phosphatase, protein tyrosine phosphatase non-receptor type 2 (PTPN2), negatively regulates IFNg signaling in non-epithelial cells...
  56. Detecting invading glioma cells through in vivo molecular imaging of the cell sur
    Susann M Brady-Kalnay; Fiscal Year: 2013
    ..PTP[unreadable] is a cell surface receptor protein tyrosine phosphatase (RPTP) and a cell adhesion molecule whose expression is down-regulated in human gliomas...
  57. Noah D Peyser; Fiscal Year: 2014
    ..Preliminary data suggests that the receptor-like protein tyrosine phosphatase T (PTPRT) directly dephosphorylates, and thus inactivates, STAT3 in OSCC preclinical models...
  58. Chen Yan; Fiscal Year: 2014
    ..1). Recently, SHP2, a protein tyrosine phosphatase (PTPase), was shown to stimulate the Apoptosis Signal-regulated Kinase (ASK1)-JNK-VCAM1 pathway...
  59. Improved Therapies for AML in the Elderly
    SARAH C NABINGER; Fiscal Year: 2011
    ..Tyrosine 599 (Y599) on WT-Flt3 has been shown to recruit the protein tyrosine phosphatase, Shp2, upon Flt3 ligand (FL) stimulation and normally activates the mitogen activated protein kinase, ..
  60. NICHOLAS A CARPINO; Fiscal Year: 2014
    ..In our ongoing effort to characterize the functions of the Sts proteins, we recently discovered a novel protein tyrosine phosphatase activity associated with the Sts PGM domain...
  61. John G Flanagan; Fiscal Year: 2016
    ..In recent work, we identified Protein Tyrosine Phosphatase sigma (PTPsigma) as a receptor for CSPGs, opening up new opportunities to study mechanisms in ..
  62. Synthesis of phosphono-CheY and phosphono-VHR
    CHRISTOPHER JOHN HALKIDES; Fiscal Year: 2010
    ..b>Protein tyrosine phosphatase enzymes break down phosphoproteins via the creation of a cysteinyl phosphate intermediate that is ..
  63. TYROSINE PHOSPHORYLATION AT THE NEUROMUSCULAR JUNCTION
    Richard Huganir; Fiscal Year: 1999
    ..protein tyrosine kinases, fyn and fyk, which phosphorylate the AChR and have characterized the major protein tyrosine phosphatase that dephosphorylates the AChR...
  64. Zhenghe Wang; Fiscal Year: 2016
    ..by applicant): The long-term goal of our proposal is to elucidate the molecular mechanisms by which protein tyrosine phosphatase T (PTPRT) functions as a tumor suppressor...
  65. Bicyclic Peptides as Inhibitors of Critical Protein-Protein Interactions
    Justin S Quartararo; Fiscal Year: 2013
    ..our platform, we seek to utilize this peptide bicycle technology for the development of inhibitors of protein tyrosine phosphatase 1B (PTP1B), a validated target of obesity and type II diabetes...
  66. Maike Krenz; Fiscal Year: 2016
    ..A candidate master regulator of cardiac stress adaptation is the protein tyrosine phosphatase SHP2...
  67. JARED TYLER AHRENDSEN; Fiscal Year: 2015
    ..We will focus on the protein tyrosine phosphatase Shp2, which may act as a brake to active myelination...
  68. Xin Zhang; Fiscal Year: 2016
    ..We have identified Shp2, a protein tyrosine phosphatase, as a key factor in orchestrating lens morphogenesis by regulating FGF signaling...
  69. Molecular mediators of tumor suppression for the PTPRD phosphatase in gliomas
    Berenice Ortiz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Receptor protein tyrosine phosphatase delta (PTPRD) is a novel tumor suppressor that is widely inactivated in glioblastoma multiforme and several other malignancies...
  70. NERVOUS TISSUE GLYCOCONJUGATES
    RICHARD MARGOLIS; Fiscal Year: 2000
    ..in limbic structures the extracellular proteoglycan phosphacan or the full-length receptor-type protein tyrosine phosphatase (RPTP-zeta/beta), of which phosphacan is an alternative splicing variant...
  71. NO-MEDIATED MODIFICATION OF NMDA RECEPTOR DURING HYPOXIA
    Om Mishra; Fiscal Year: 2006
    ..We propose that NO free radicals generated during hypoxia lead to inactivation of protein tyrosine phosphatase (PIP) and mitogen-activated kinase phosphatase1 (MKP-1) and MKP-3...
  72. Molecular mechanism of immune evasion by Yersinia pestis
    Tomas Mustelin; Fiscal Year: 2003
    ..component of the molecular machinery by which Yersinia pestis evades the immune system, a highly active protein tyrosine phosphatase (PTPase) termed YopH...
  73. REGULATION OF GRANULOCYTE AND MACROPHAGE PRODUCTION
    E Stanley; Fiscal Year: 2001
    ..4. To analyze to role to protein tyrosine phosphatase-phi in macrophage survival, proliferation and function...
  74. Stat5 dephosphorylation by Shp-2
    Demin Wang; Fiscal Year: 2007
    ..abstract_text> ..
  75. Virginia L Willour; Fiscal Year: 2015
    ..The associated SNPs on 2p25 fall in a large linkage disequilibrium block that contains the ACP1 gene, whose expression is significantly elevated in bipolar disorder (BP) subjects who have completed suicide...
  76. REGULATION OF INTERFERON ACTIVITY BY SHP-1 IN THE CNS
    PAUL MASSA; Fiscal Year: 2007
    ..a much higher degree and causes more extensive demyelination in the CNS of mice genetically lacking the protein tyrosine phosphatase SHP-1 compared to wild type mice expressing SHP-1...
  77. Immune Tolerence to Transplanted Myoblasts
    David M Rothstein; Fiscal Year: 2010
    ..will utilize newly emerging strategies that incorporate mAbs against the higher Mr isoforms of the CD45 protein tyrosine phosphatase (anti-CD45RB)...
  78. REGULATION/INSULIN SECRETION BY PROTEIN PHOSPHORYLATION
    John Hutton; Fiscal Year: 2003
    ..We have identified an insulin granule membrane protein tyrosine phosphatase (P.T..P...
  79. Molecular Pathogenesis of the Cardiomyogenic Defects in LEOPARD Syndrome
    MARIA IRENE KONTARIDIS; Fiscal Year: 2010
    SUMMARY: Recently, mutations in the SH2 domain-containing protein tyrosine phosphatase Shp2, have been implicated in cardiac disease...
  80. Deficiency of SHP-1 expression and function in multiple sclerosis
    Paul T Massa; Fiscal Year: 2010
    Numerous studies have shown that the protein tyrosine phosphatase SHP-1 modulates the expression of proinflammatory genes in leukocytes and glia that have been shown to cause inflammatory demyelination in the CNS...