acetylcholinesterase

Summary

Gene Symbol: acetylcholinesterase
Description: acetylcholinesterase (Cartwright blood group)
Alias: ACEE, ARACHE, N-ACHE, acetylcholinesterase, Yt blood group, acetylcholinesterase (Yt blood group), apoptosis-related acetylcholinesterase
Species: human

Top Publications

  1. ncbi Acetylcholinesterase--new roles for an old actor
    H Soreq
    Nat Rev Neurosci 2:294-302. 2001
  2. pmc Presenilin 1 interacts with acetylcholinesterase and alters its enzymatic activity and glycosylation
    Maria Ximena Silveyra
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez CSIC, Crta Alicante Valencia Km 87, Sant Joan d Alacant E 03550, Spain
    Mol Cell Biol 28:2908-19. 2008
  3. ncbi The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant
    B Velan
    Department of Biochemistry, Israel Institute for Biological Research, Ness Ziona
    J Biol Chem 266:23977-84. 1991
  4. pmc N-glycosylation of human acetylcholinesterase: effects on activity, stability and biosynthesis
    B Velan
    Department of Biochemistry, Israel Institute for Biological Research, Ness Ziona
    Biochem J 296:649-56. 1993
  5. ncbi Alternative splicing and neuritic mRNA translocation under long-term neuronal hypersensitivity
    Eran Meshorer
    Department of Biological Chemistry, The Institute of Life Sciences and The Eric Roland Center for Neurodegenerative Diseases, The Hebrew University of Jerusalem, Israel 91904
    Science 295:508-12. 2002
  6. ncbi PRiMA: the membrane anchor of acetylcholinesterase in the brain
    Anselme L Perrier
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Neuron 33:275-85. 2002
  7. ncbi Human acetylcholinesterase binds to mouse laminin-1 and human collagen IV by an electrostatic mechanism at the peripheral anionic site
    Glynis Johnson
    Department of Pediatric Surgery, University of Stellenbosch, Faculty of Health Sciences, Tygerberg, South Africa
    Neurosci Lett 337:37-40. 2003
  8. pmc Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study
    Ella H Sklan
    Department of Biological Chemistry, Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Proc Natl Acad Sci U S A 101:5512-7. 2004
  9. ncbi Mouse acetylcholinesterase interacts in yeast with the extracellular matrix component laminin-1beta
    Laura E Paraoanu
    Technical University Darmstadt, Institute of Zoology, Department of Developmental Biology and Neurogenetics, Schnittspahnstr 3, 64287 Darmstadt, Germany
    FEBS Lett 576:161-4. 2004
  10. pmc The human gene encoding acetylcholinesterase is located on the long arm of chromosome 7
    D K Getman
    Department of Pharmacology, University of California San Diego, La Jolla 92093 0636
    Am J Hum Genet 51:170-7. 1992

Detail Information

Publications424 found, 100 shown here

  1. ncbi Acetylcholinesterase--new roles for an old actor
    H Soreq
    Nat Rev Neurosci 2:294-302. 2001
    ..of the first neurotransmitter--acetylcholine--was soon followed by the discovery of its hydrolysing enzyme, acetylcholinesterase. The role of acetylcholinesterase in terminating acetylcholine-mediated neurotransmission made it the focus ..
  2. pmc Presenilin 1 interacts with acetylcholinesterase and alters its enzymatic activity and glycosylation
    Maria Ximena Silveyra
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez CSIC, Crta Alicante Valencia Km 87, Sant Joan d Alacant E 03550, Spain
    Mol Cell Biol 28:2908-19. 2008
    ..We report here the coimmunoprecipitation of PS1 and acetylcholinesterase (AChE), an enzyme associated with amyloid plaques...
  3. ncbi The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant
    B Velan
    Department of Biochemistry, Israel Institute for Biological Research, Ness Ziona
    J Biol Chem 266:23977-84. 1991
    Site-directed mutagenesis was used to study the cysteine residue involved in the assembly of human acetylcholinesterase (HuAChE) catalytic subunits...
  4. pmc N-glycosylation of human acetylcholinesterase: effects on activity, stability and biosynthesis
    B Velan
    Department of Biochemistry, Israel Institute for Biological Research, Ness Ziona
    Biochem J 296:649-56. 1993
    The role of N-glycosylation in the function of human acetylcholinesterase (HuAChE) was examined by site-directed mutagenesis (Asn to Gln substitution) of the three potential N-glycosylation sites Asn-265, Asn-350 and Asn-464...
  5. ncbi Alternative splicing and neuritic mRNA translocation under long-term neuronal hypersensitivity
    Eran Meshorer
    Department of Biological Chemistry, The Institute of Life Sciences and The Eric Roland Center for Neurodegenerative Diseases, The Hebrew University of Jerusalem, Israel 91904
    Science 295:508-12. 2002
    ..long-term consequences of stress, we studied stress-induced changes in the neuritic translocation of acetylcholinesterase (AChE) splice variants. Under normal conditions, we found the synaptic AChE-S mRNA and protein in neurites...
  6. ncbi PRiMA: the membrane anchor of acetylcholinesterase in the brain
    Anselme L Perrier
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Neuron 33:275-85. 2002
    As a tetramer, acetylcholinesterase (AChE) is anchored to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses. We have previously shown that collagen Q (ColQ) anchors AChE at the neuromuscular junction...
  7. ncbi Human acetylcholinesterase binds to mouse laminin-1 and human collagen IV by an electrostatic mechanism at the peripheral anionic site
    Glynis Johnson
    Department of Pediatric Surgery, University of Stellenbosch, Faculty of Health Sciences, Tygerberg, South Africa
    Neurosci Lett 337:37-40. 2003
    b>Acetylcholinesterase (EC 3.1.1.7; AChE) is known to induce neurite outgrowth and differentiation, but its ligands are as yet unknown. Laminin-1 and collagen IV were investigated as potential ligands for AChE...
  8. pmc Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study
    Ella H Sklan
    Department of Biological Chemistry, Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Proc Natl Acad Sci U S A 101:5512-7. 2004
    ..interrelationships between expression variations and nucleotide polymorphisms of the chromosome 7q21-22 acetylcholinesterase-paraoxonase 1 (ACHE-PON1) locus with the trait- and state-anxiety measures of 461 healthy subjects from the ..
  9. ncbi Mouse acetylcholinesterase interacts in yeast with the extracellular matrix component laminin-1beta
    Laura E Paraoanu
    Technical University Darmstadt, Institute of Zoology, Department of Developmental Biology and Neurogenetics, Schnittspahnstr 3, 64287 Darmstadt, Germany
    FEBS Lett 576:161-4. 2004
    b>Acetylcholinesterase (AChE) is likely to have roles other than the hydrolysis of acetylcholine, e.g., related to developmental processes like neurite outgrowth, differentiation and adhesion...
  10. pmc The human gene encoding acetylcholinesterase is located on the long arm of chromosome 7
    D K Getman
    Department of Pharmacology, University of California San Diego, La Jolla 92093 0636
    Am J Hum Genet 51:170-7. 1992
    b>Acetylcholinesterase (AChE) is a secreted enzyme essential for regulating cholinergic neurotransmission at neuronal and neuromuscular synapses...
  11. ncbi Combinatorial complexity of 5' alternative acetylcholinesterase transcripts and protein products
    Eran Meshorer
    Department of Biological Chemistry and the Israel Center of Neuronal Computation, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    J Biol Chem 279:29740-51. 2004
    ..inter-relationship to alternative splicing, we searched expression sequence tags for the 5' region of acetylcholinesterase (ACHE) genes. Three and five novel first exons were identified in human and mouse ACHE genes, respectively...
  12. ncbi Virtues and woes of AChE alternative splicing in stress-related neuropathologies
    Eran Meshorer
    National Cancer Institute, National Institutes of Health, Building 41, 41 Library Drive, Bethesda, MD 20892, USA
    Trends Neurosci 29:216-24. 2006
    The ACh hydrolyzing enzyme acetylcholinesterase (AChE) is a combinatorial series of proteins with variant N and C termini generated from alternate promoter usage and 3' alternative splicing...
  13. ncbi Cortical acetylcholine esterase activity and ApoE4-genotype in Alzheimer disease
    Carsten Eggers
    Department of Neurology, University of Cologne, Germany
    Neurosci Lett 408:46-50. 2006
    ..041, p<0.05) in the ApoE4 negative group only. These results indicate that cortical AChE activity is relatively well preserved in ApoE4 carriers, either by preservation of its cellular expression or as AChE activity in amyloid plaques...
  14. pmc Blockade of nicotinic responses by physostigmine, tacrine and other cholinesterase inhibitors in rat striatum
    P B Clarke
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada
    Br J Pharmacol 111:695-702. 1994
    1. The acetylcholinesterase inhibitors physostigmine, neostigmine, tetrahydroaminoacridine (tacrine; THA) and diisopropylfluorophosphate (DFP) were tested for possible direct nicotinic actions in rat striatal synaptosomes preloaded with [..
  15. ncbi Neurochemical measurements in the brains of mice infected with Trypanosoma brucei brucei (TREU 667)
    B Amole
    Faculty of Health Sciences, University Obafemi Awolowo, Ile Ife, Nigeria
    Ann Trop Med Parasitol 83:225-32. 1989
    ..acetylcholine receptor numbers, activities of the cholinergic enzymes, choline acetyltransferase (CAT), and acetylcholinesterase (AChE), and regional concentrations of the monoamines, dopamine (DA), serotonin (5-HT), and norepinephrine (..
  16. pmc Poly-L-arginine-mediated release of acetylcholine from parasympathetic nerves in rat and guinea-pig airways
    D Spina
    Department of Pharmacology, University of Western Australia, Nedlands
    Br J Pharmacol 112:895-900. 1994
    ..1 microM) and augmented by the acetylcholinesterase inhibitor, ecothiophate (0.1 microM)...
  17. ncbi Capillary electrophoresis of cardiovascular drugs
    N T Nguyen
    Parke-Davis, Pharmaceutical Analytical Research, Morris Plains, NJ 07950, USA
    J Chromatogr A 735:123-50. 1996
    ..The classes presented are beta-adrenergic antagonists (beta-blockers), acetylcholinesterase inhibitors, angiotensin-converting enzyme inhibitors, dieuretics, alpha-adrenergic antagonists, calcium ..
  18. ncbi Mechanism of death in Syrian hamsters gavaged potato sprout material
    D C Baker
    USDA ARS Poisonous Plant Research Laboratory, Logan, Utah 84321
    Toxicol Pathol 16:333-9. 1988
    ..Potato alkaloids can cause death when parenterally administered, and is attributed to the acetylcholinesterase inhibitory activity of solanine and chaconine...
  19. ncbi Ultrastructural and histochemical study of the motor end plates of the intrinsic laryngeal muscles in amyotrophic lateral sclerosis
    T Yoshihara
    Department of Otolaryngology, Tokyo Women s Medical College, Japan
    Ultrastruct Pathol 22:121-6. 1998
    ..b>Acetylcholinesterase (AchE) activities of the neuromuscular junctions (NMJ) of many fibers in ALS were decreased as compared ..
  20. ncbi Origin of nerves supplying the posterior portion of lumbar intervertebral discs in rats
    S Nakamura
    Department of Orthopaedic Surgery, School of Medicine, Chiba University, Japan
    Spine (Phila Pa 1976) 21:917-24. 1996
    ..resection of sympathetic trunks with ganglia at different levels, the whole lumbar spine was stained by an acetylcholinesterase histochemical method. The posterior portions of lumbar intervertebral discs were observed. RESULTS...
  21. ncbi Effect of age on acetylcholinesterase and other hemolymph proteins in Aplysia
    M Srivatsan
    Department of Physiology and Biophysics, University of Kentucky Medical Center, Lexington 40536 0084
    J Comp Physiol B 162:29-37. 1992
    ..b>Acetylcholinesterase (AChE) was present in the hemolymph of Aplysia...
  22. ncbi Neurotization of the rat soleus muscle: a quantitative analysis of reinnervation
    S H Payne
    Microsurgical Laboratory, Raymond Curtis Hand Center, Union Memorial Hospital, Baltimore, MD, USA
    J Hand Surg Am 22:640-3. 1997
    ..The underlying neurobiology, however, has not been adequately studied. The use of a combined silver-acetylcholinesterase stain was used in this study to identify reinnervated motor endplates and to quantify motor endplates ..
  23. ncbi Effect of pyridostigmine on the hydrocortisone-mediated decrease of circulating growth hormone levels in acromegaly
    A Giustina
    Cattedra di Clinica Medica, University of Brescia, Italy
    Horm Metab Res 26:288-92. 1994
    The aims of our study were to investigate the effect of the acetylcholinesterase inhibitor pyridostigmine (PD) administration on growth hormone (GH) secretion in acromegaly and to investigate the effects of PD on GH levels following an i...
  24. ncbi Reduced calcium binding capacity is an intrinsic abnormality of red blood cell membrane in spontaneously hypertensive rats
    M Cirillo
    Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples, Italy
    Am J Hypertens 3:570-2. 1990
    ..In addition to Ca binding capacity and protein content, the cholesterol content and the acetylcholinesterase (ACE) activity were measured as having a quantitative measure of integral membrane components in the ..
  25. ncbi Acetylcholinesterase and insect growth inhibitory activities of Gutierrezia microcephala on fall armyworm Spodoptera frugiperda J.E. Smith
    J S Calderón
    Instituto de Quimica, Universidad Nacional Autonoma de Mexico, DF, Mexico
    Z Naturforsch C 56:382-94. 2001
    ..05, 10.78, and 12.79 ppm, respectively. In addition, MeOH, n-hexane extracts, 5, 6 and gedunin caused acetylcholinesterase inhibition with 93.7, 100, 90.2, 62.0 and 100% at 50...
  26. pmc Change in serum cholinesterase activity in Jamaican diabetics
    D Ragoobirsingh
    Department of Biochemistry, University of West Indies, Kingston, Jamaica
    J Natl Med Assoc 84:853-5. 1992
    ..5 years; mean body mass index, 24.0 +/- 0.8 kg/m2; and mean duration of diabetes, 14.2 +/- 2.2 years. Serum acetylcholinesterase, insulin, triglyceride, and cholesterol levels as well as fasting blood sugar were all assayed using ..
  27. ncbi Myopathic alterations in extraocular muscle of rats subchronically fed pyridostigmine bromide
    S T Schuschereba
    Letterman Army Institute of Research, Presidio of San Francisco, California 94129 6800
    Toxicol Pathol 18:387-95. 1990
    ..Within the first day, blood acetylcholinesterase activity was reduced by 87% and remained inhibited by 74-91% during the study...
  28. pmc Field evaluation of methods for estimating carbamate resistance in Anopheles albimanus mosquitos from a microplate assay for insensitive acetylcholinesterase
    C Cordon-Rosales
    Center for Research in Tropical Diseases, Universidad del Valle de Guatemala, Guatemala City
    Bull World Health Organ 68:323-9. 1990
    ..bioassay (WHO test) from the results of a biochemical assay for detecting the insensitivity of acetylcholinesterase (AChE) is described...
  29. ncbi [Pharmacological treatment of Alzheimer's disease: present situation and perspectives]
    F Jane
    Hospital de la Santa Creu i Sant Pau, Departamento de Farmacologia y Psiquiatria, Universidad Autonoma de Barcelona
    Rev Neurol 23:103-7. 1995
    ..The attempt of activating the cholinergic system has deserved special attention. A reversible inhibitor of acetylcholinesterase, tacrine, has been approved in the United States and other countries for the symptomatic treatment of mild ..
  30. ncbi [Compartmentalized organization of human corpus striatum]
    L Prensa
    , Facultad de Medicina, Universidad de Navarra, Pamplona,
    Rev Neurol 28:512-9. 1999
    ..described in the human striatum, as well as in the cats and primates, zones poorly stained for the enzyme acetylcholinesterase, which they termed striosomes, that lie in more intensely stained matrix...
  31. ncbi In vitro influence of phenylalanine on acetylcholinesterase activity and DNA
    K H Schulpis
    Institute of Child Health, Aghia Sophia Children s Hospital, Athens, Greece
    Z Naturforsch C 53:291-3. 1998
    b>Acetylcholinesterase (AChE) is a significant component of the membrane contributing to the permeability changes during synaptic transmission and conduction...
  32. ncbi L-phenylalanine effect on rat diaphragm acetylcholinesterase and Na+,K(+)-ATPase
    S Tsakiris
    Department of Experimental Physiology, University of Athens, Medical School, Cholargos, Greece
    Z Naturforsch C 53:1055-60. 1998
    The effect of different L-phenylalanine (Phe) concentrations (0.24-12.1 mM), on acetylcholinesterase (AChE) and Na+,K(+)-ATPase activities of diaphragm homogenates from 21-day old rats and pure enzymes, was investigated at 37 degrees C...
  33. ncbi An insensitive acetylcholinesterase confers resistance to methomyl in the beet armyworm Spodoptera exigua (Lepidoptera: Noctuidae)
    F J Byrne
    Department of Entomology, University of California, Riverside 92521, USA
    J Econ Entomol 94:524-8. 2001
    Two forms of acetylcholinesterase were identified in field populations of the beet armyworm, Spodoptera exigua (Hübner), collected from cotton in San Joaquin Valley, CA...
  34. ncbi Modulation of the activities of membrane enzymes by cereal grain resorcinolic lipids
    A Kozubek
    , , Poland
    Z Naturforsch C 47:41-6. 1992
    ..The concentrations for 50% inhibition of erythrocyte membrane acetylcholinesterase were in the range of 18-90 microM and were dependent on the length of the aliphatic side chain of the ..
  35. ncbi L-phenylalanine effect on rat brain acetylcholinesterase and Na+,K(+)-ATPase
    S Tsakiris
    Department of Experimental Physiology, University of Athens, Medical School, Greece
    Z Naturforsch C 53:163-7. 1998
    The effect of different L-phenylalanine (Phe) concentrations (0.1-12.1 mM), on acetylcholinesterase (AChE) and Na+,K(+)-ATPase activities of brain homogenate and pure enzymes, was investigated at 37 degrees C...
  36. ncbi Pyridostigmine effects on TSH response to TRH in adult and children obese subjects
    A Mancini
    Institute of Endocrinology, Catholic University School of Medicine, Rome, Italy
    Horm Metab Res 25:309-11. 1993
    ..Further studies have shown that pyridostigmine (Pyr), an acetylcholinesterase inhibitor, is capable of augmenting GH in obesity by means of somatostatin inhibition...
  37. ncbi Effect of Mg(2+)-ATP on acetylcholinesterase of Electrophorus electricus (L.)
    A Nery da Matta
    Departamento de Biologia Celular e Molecular, Universidade Federal Fluminense, Niteroi, RJ, Brasil
    Z Naturforsch C 51:65-9. 1996
    The effect of Mg(2+)-ATP on purified acetylcholinesterase (AChE) from electric tissue of Electrophorus electricus (L.) was studied. The enzymatic activities were measured with acetylcholine and acetylthiocholine as substrates...
  38. ncbi A long-term follow-up study of cerebrospinal fluid acetylcholinesterase in delirium
    H J Koponen
    Department of Psychiatry, University of Turku, Finland
    Eur Arch Psychiatry Clin Neurosci 243:347-51. 1994
    Cerebrospinal fluid acetylcholinesterase (CSF AChE) was determined for elderly delirious patients during the acute stage and after a 1- and 4-year follow-up periods, and the AChE levels were compared with age-equivalent controls...
  39. ncbi High-performance liquid chromatography with on-line coupled UV, mass spectrometric and biochemical detection for identification of acetylcholinesterase inhibitors from natural products
    K Ingkaninan
    Division of Pharmacognosy, Leiden/Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, The Netherlands
    J Chromatogr A 872:61-73. 2000
    ..HPLC) method with on-line coupled ultraviolet (UV), mass spectrometry (MS) and biochemical detection for acetylcholinesterase (AChE) inhibitory activity has been developed...
  40. ncbi Innervation of "painful" lumbar discs
    M H Coppes
    Department of Neurosurgery, Groningen University, The Netherlands
    Spine (Phila Pa 1976) 22:2342-9; discussion 2349-50. 1997
    ..METHODS: The presence of nerve fibers was investigated using acetylcholinesterase enzyme histochemistry, as well as neurofilament and substance P immunocytochemistry...
  41. ncbi Perfusion immunoassay for acetylcholinesterase: analyte detection based on intrinsic activity
    M Vanderlaan
    PerSeptive Biosystems, Framingham, MA 01701, USA
    J Chromatogr A 711:23-31. 1995
    ..proteins are first fractionated on a size-exclusion column; the fraction containing the M(r) 280,000 neural acetylcholinesterase (AChE) is then diverted to a second column, an ImmunoDetection cartridge derivatized with an anti-AChE ..
  42. ncbi Effect of aging on the activities of acetylcholinesterase, Na+,K(+)-ATPase and Mg(2+)-ATPase in rat pituitary and hypothalamus
    S Tsakiris
    Department of Experimental Physiology, University of Athens, Medical School, Greece
    Z Naturforsch C 53:168-72. 1998
    b>Acetylcholinesterase (AChE), Na+,K(+)-ATPase and Mg(2+)-ATPase activities were estimated in homogenised rat pituitary and hypothalamus of 4- and 22-month-old rats...
  43. ncbi Screening for acetylcholinesterase inhibitors from Amaryllidaceae using silica gel thin-layer chromatography in combination with bioactivity staining
    I K Rhee
    Division of Pharmacognosy, Leiden/Amsterdam Center for Drug Research, Leiden University, The Netherlands
    J Chromatogr A 915:217-23. 2001
    Thin-layer chromatography (TLC) was used to screen for acetylcholinesterase inhibitors from Amaryllidaceae extracts...
  44. ncbi Direct determination of E2020 enantiomers in plasma by liquid chromatography-mass spectrometry and column-switching techniques
    K Matsui
    Department of Drug Metabolism and Pharmacokinetics, Tsukuba Research Laboratories, Eisai Co, Ltd, Ibarak, Japan
    J Chromatogr A 694:209-18. 1995
    ..mass spectrometry (MS) was applied to the on-line determination and resolution of the enantiomers of E2020 (acetylcholinesterase inhibitor) in plasma. This system employs two avidin columns and fast atom bombardment (FAB)-MS...
  45. ncbi Nerves accompanying the vertebral artery and their clinical relevance
    X Q Chen
    Department of Anatomy, First Medical University of PLA, Guangzhou, China
    Spine (Phila Pa 1976) 13:1360-4. 1988
    ..artery were studied under an operative microscope and by means of Karnovsky's histochemical method for acetylcholinesterase (AChE)...
  46. ncbi Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex vivo exposure to soman
    Richard K Gordon
    Walter Reed Army Institute of Research, Division of Biochemistry, 503 Robert Grant Rd, Silver Spring, MD 20910 7500, USA
    Chem Biol Interact 157:239-46. 2005
    Cholinesterases (ChEs) are classified as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) according to their substrate specificity and sensitivity to selected inhibitors...
  47. ncbi Inhibition of acetylcholinesterase and butyrylcholinesterase by chlorpyrifos-oxon
    G Amitai
    Division of Biochemistry, Walter Reed Army Institute of Research, Washington, DC 20307 5100, USA
    Biochem Pharmacol 56:293-9. 1998
    ..The insecticidal action of chlorpyrifos stems from inhibition of acetylcholinesterase (AChE) by CPO, resulting in severe cholinergic toxicity...
  48. pmc Evolution of acetylcholinesterase and butyrylcholinesterase in the vertebrates: an atypical butyrylcholinesterase from the Medaka Oryzias latipes
    Leo Pezzementi
    Department of Biology, Birmingham Southern College, Birmingham, Alabama, United States of America
    PLoS ONE 6:e17396. 2011
    b>Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are thought to be the result of a gene duplication event early in vertebrate evolution...
  49. ncbi Differential inhibition of [3H]-oxotremorine-M and [3H]-quinuclinidyl benzilate binding to muscarinic receptors in rat brain membranes with acetylcholinesterase inhibitors
    B Lockhart
    Institut de Recherches Servier, Division of Cerebral Pathology, Croissy sur Seine, France
    Naunyn Schmiedebergs Arch Pharmacol 363:429-38. 2001
    The potential interaction of acetylcholinesterase inhibitors with cholinergic receptors may play a significant role in the therapeutic and/or side-effects associated with this class of compound...
  50. ncbi Blood and bronchoalveolar lavage fluid acetylcholinesterase levels following microinstillation inhalation exposure to sarin in Guinea pigs
    Magnus M Che
    Division of Biochemistry, Department of Biochemical Pharmacology, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    Inhal Toxicol 20:821-8. 2008
    We determined acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition in the bronchoalveolar lavage fluid (BALF) following inhalation exposure to chemical threat nerve agent (CTNA) sarin...
  51. ncbi Effects of oximes on muscle force and acetylcholinesterase activity in isolated mouse hemidiaphragms exposed to paraoxon
    Horst Thiermann
    Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstr 11, 80937 München, Gemany
    Toxicology 214:190-7. 2005
    Toxicity of organophosphates (OP) is caused by inhibition of acetylcholinesterase (AChE), resulting in accumulation of acetylcholine...
  52. doi Effects of adult-onset choline deprivation on the activities of acetylcholinesterase, (Na+,K+)- and Mg2+-ATPase in crucial rat brain regions
    Charis Liapi
    Department of Pharmacology, Medical School, University of Athens, Athens, Greece
    Food Chem Toxicol 47:82-5. 2009
    ..The aim of this study was to investigate the effect of a 2-month adult-onset CD on the activities of acetylcholinesterase (AChE), (Na+,K+)- and Mg2+-ATPase in crucial brain regions of male rats...
  53. ncbi Mapping and sequencing of acetylcholinesterase genes from the platyhelminth blood fluke Schistosoma
    Geoffrey N Bentley
    The School of Biology, University of Leeds, West Yorkshire, LS2 9JT, Leeds, UK
    Gene 314:103-12. 2003
    b>Acetylcholinesterase (AChE) on the surface of the parasitic blood fluke Schistosoma is the likely target for schistosomicidal anticholinesterases...
  54. ncbi Enzyme-kinetic investigation of different sarin analogues reacting with human acetylcholinesterase and butyrylcholinesterase
    A Bartling
    Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937 Munich, Germany
    Toxicology 233:166-72. 2007
    ..OP inhibit acetylcholinesterase (AChE) and therefore standard treatment of respective poisoning includes AChE reactivators (oximes) in ..
  55. ncbi Immunologically induced sympathectomy of preganglionic nerves by antibodies against acetylcholinesterase: increased levels of peptides and their messenger RNAs in rat adrenal chromaffin cells
    A Dagerlind
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Neuroscience 62:217-39. 1994
    Systemic administration of murine monoclonal acetylcholinesterase antibodies to rats has been shown to cause selective degeneration of sympathetic preganglionic neurons. In the present study rats were subjected to a single i.v...
  56. ncbi Acetylcholinesterase (AChE) gene modification in transgenic animals: functional consequences of selected exon and regulatory region deletion
    Shelley Camp
    University of California, San Diego, 9500 Gilman Dr, Department of Pharmacology, La Jolla, CA 92093 0636, USA
    Chem Biol Interact 157:79-86. 2005
    ..Li, S. Camp, P. Taylor, Tissue-specific expression and alternative mRNA processing of the mammalian acetylcholinesterase gene. J. Biol. Chem. 268 (8) (1993) 5790-5797]...
  57. doi Protection of red blood cell acetylcholinesterase by oral huperzine A against ex vivo soman exposure: next generation prophylaxis and sequestering of acetylcholinesterase over butyrylcholinesterase
    Julian R Haigh
    Walter Reed Army Institute of Research, Division of Biochemistry, 503 Robert Grant Road, Silver Spring, MD 20910 7500, USA
    Chem Biol Interact 175:380-6. 2008
    As part of a phase Ib clinical trial to determine the tolerability and safety of the highly specific acetylcholinesterase (AChE) inhibitor huperzine A, twelve (12) healthy elderly individuals received an escalating dose regimen of ..
  58. ncbi Applications of carboxylesterase activity in environmental monitoring and toxicity identification evaluations (TIEs)
    Craig E Wheelock
    Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles vag 2, SE 171 77 Stockholm, Sweden
    Rev Environ Contam Toxicol 195:117-78. 2008
    ..g., acetylcholinesterase)...
  59. ncbi Comparative study of acetylcholinesterase and butyrylcholinesterase in brain and serum of several freshwater fish: specific activities and in vitro inhibition by DDVP, an organophosphorus pesticide
    G M Chuiko
    The Institute of Wildlife and Environmental Toxicology TIWET, Clemson University, Pendleton, SC 29670, USA
    Comp Biochem Physiol C Toxicol Pharmacol 127:233-42. 2000
    A comparative study of specific activities and in vitro inhibition of brain and serum acetylcholinesterase (AChE; EC 3.1.1.7) and serum butyrylcholinesterase (BChE; EC 3.1.1...
  60. doi Protection by pyridostigmine bromide of marmoset hemi-diaphragm acetylcholinesterase activity after soman exposure
    Julian R Haigh
    Department of Regulated Laboratories, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Chem Biol Interact 187:416-20. 2010
    ..Organophosphate (OP) chemical warfare agents such as GD exert their toxic effects by inhibiting acetylcholinesterase (AChE) from terminating the action of acetylcholine at postsynaptic sites in cholinergic nerve terminals (..
  61. doi Assessment of acetylcholinesterase activity in Clarias gariepinus as a biomarker of organophosphate and carbamate exposure
    Robinson H Mdegela
    Department of Veterinary Medicine and Public Health, Sokoine University of Agriculture, Morogoro, Tanzania
    Ecotoxicology 19:855-63. 2010
    The objective of this study was to investigate the response of acetylcholinesterase (AChE) activities in Clarias gariepinus in response to Organophosphates (Ops) and carbamate exposure...
  62. pmc Construction and characterization of secreted and chimeric transmembrane forms of Drosophila acetylcholinesterase: a large truncation of the C-terminal signal peptide does not eliminate glycoinositol phospholipid anchoring
    J P Incardona
    Department of Genetics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Mol Biol Cell 7:595-611. 1996
    ..We have focused on Drosophila acetylcholinesterase (AChE) as a model GPI-anchored protein that can be manipulated in vivo with sophisticated genetic ..
  63. ncbi Effect of thyroid hormones on acetylcholinesterase mRNA levels in the slow soleus and fast extensor digitorum longus muscles of the rat
    P Pregelj
    Institute of Pathophysiology, School of Medicine, University of Ljubljana, Slovenia
    Neuroscience 116:657-67. 2003
    In the rat, the level of acetylcholinesterase messenger RNA in the typical slow soleus muscles is only about 20-30% of that in the fast extensor digitorum longus muscles...
  64. ncbi The C-terminal peptides of acetylcholinesterase: cellular trafficking, oligomerization and functional anchoring
    Jean Massoulié
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Chem Biol Interact 157:3-14. 2005
    In vertebrates, the catalytic domain of acetylcholinesterase (AChE) may be associated with several C-terminal peptides generated by alternative splicing in the 3' region of transcripts...
  65. pmc Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon, and diazinon
    Ruth R Jameson
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 115:65-70. 2007
    ..pesticides affect mammalian brain development through mechanisms separable from the inhibition of acetylcholinesterase (AChE) enzymatic activity and resultant cholinergic hyperstimulation...
  66. ncbi Acetylcholinesterase and butyrylcholinesterase expression in adult rabbit tissues and during development
    O Jbilo
    Laboratorire de Différenciation cellulaire et Croissance, INRA, Montpellier, France
    Eur J Biochem 225:115-24. 1994
    A large cDNA fragment covering the complete sequence of the mature catalytic subunit of rabbit acetylcholinesterase (AChE) has been cloned and sequenced. This sequence was compared to that of rabbit butyrylcholinesterase [BChE; Jbilo, O...
  67. ncbi The acetylcholinesterase gene and organophosphorus resistance in the Australian sheep blowfly, Lucilia cuprina
    Z Chen
    CESAR Centre for Environmental Stress and Adaptation Research, Genetics Department, University of Melbourne, Parkville 3052, Australia
    Insect Biochem Mol Biol 31:805-16. 2001
    b>Acetylcholinesterase (AChE), encoded by the Ace gene, is the primary target of organophosphorous (OP) and carbamate insecticides. Ace mutations have been identified in OP resistants strains of Drosophila melanogaster...
  68. doi The neuroprotective role of L-cysteine towards the effects of short-term exposure to lanthanum on the adult rat brain antioxidant status and the activities of acetylcholinesterase, (Na+,K+)- and Mg2+-ATPase
    Charis Liapi
    Department of Pharmacology, Medical School, University of Athens, Athens, Greece
    Biometals 22:329-35. 2009
    ..as LaCl(3), 53 mg/kg) on the adult rat whole brain total antioxidant status (TAS) and the activities of acetylcholinesterase (AChE), Na(+),K(+)-ATPase and Mg(2+)-ATPase, as well as the potential effect of the co-administration of ..
  69. ncbi Catalytic antibodies with acetylcholinesterase activity
    Glynis Johnson
    Department of Pediatric Surgery Medical Biochemistry, University of Stellenbosch, P O Box 19063, Tygerberg 7505, South Africa
    J Immunol Methods 269:13-28. 2002
    ..The Ab1s were raised against the human erythrocyte acetylcholinesterase (AChE), and are unusual in that they both recognise and resemble acetylcholinesterase in their catalytic ..
  70. doi Comparison of human and guinea pig acetylcholinesterase sequences and rates of oxime-assisted reactivation
    C Linn Cadieux
    U S Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, Aberdeen Proving Ground Edgewood Area, MD 21010 5400, USA
    Chem Biol Interact 187:229-33. 2010
    Poisoning via organophosphorus (OP) nerve agents occurs when the OP binds and inhibits the enzyme acetylcholinesterase (AChE)...
  71. ncbi Control levels of acetylcholinesterase expression in the mammalian skeletal muscle
    Z Grubic
    Institute of Pathophysiology, School of Medicine, University of Ljubljana, Slovenia
    Chem Biol Interact 119:309-19. 1999
    Protein expression can be controled at different levels. Understanding acetylcholinesterase (EC. 3.1.1...
  72. ncbi Acceleration of oxime-induced reactivation of organophosphate-inhibited fetal bovine serum acetylcholinesterase by monoquaternary and bisquaternary ligands
    C Luo
    Division of Biochemistry, Walter Reed Army Institute of Research, Washington, DC 20307 5100, USA
    Mol Pharmacol 53:718-26. 1998
    Reactivation of organophosphate (OP)-inhibited acetylcholinesterase (AChE) by oximes is the primary reason for their effectiveness in the treatment of OP poisoning...
  73. ncbi Tissue cholinesterases. A comparative study of their kinetic properties
    K R Dave
    Department of Biochemistry, Faculty of Science, M S University of Baroda, Vadodara, India
    Z Naturforsch C 55:100-8. 2000
    ..Membrane binding of the enzyme resulted in decreased energy of activation with shift in phase transition temperature (Tt) to near physiological temperature...
  74. ncbi Effects of antibodies against acetylcholinesterase on the expression of peptides and catecholamine synthesizing enzymes in the rat adrenal gland
    A Dagerlind
    Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden
    Neuroscience 54:1079-90. 1993
    In the rat, systemic administration of murine monoclonal antibodies against acetylcholinesterase caused rapid piloerection and ptosis (within 30-60 min after the injection)...
  75. doi A sol-gel-derived acetylcholinesterase microarray for nanovolume small-molecule screening
    Maria Rowena N Monton
    Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St W, Hamilton, Ontario L8S 4M1, Canada
    Anal Chem 82:9365-73. 2010
    A fluorimetric acetylcholinesterase (AChE) assay was developed and characterized both in solution and with the enzyme entrapped in sol-gel-derived silica...
  76. ncbi The effect of in vitro homocystinuria on the suckling rat hippocampal acetylcholinesterase
    Kleopatra H Schulpis
    Inborn Errors of Metabolism Department, Institute of Child Health Research Center, Aghia Sophia Children s Hospital, Athens, Greece
    Metab Brain Dis 21:21-8. 2006
    ..Since these symptoms may be closely implicated with acetylcholinesterase (AChE) activity, we aimed to investigate whether this metabolic disorder affects the hippocampal AChE ..
  77. doi Reciprocal neural regulation of extrajunctional acetylcholinesterase and collagen Q in rat muscles--the role of calcineurin signaling
    Miha Trinkaus
    Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia
    Chem Biol Interact 175:45-9. 2008
    There are two main differences regarding acetylcholinesterase (AChE) expression in the extrajunctional regions of fast and slow rat muscles: (1) the activity of AChE catalytic subunits (G1 form) is much higher in fast than in slow muscles,..
  78. ncbi Remodeling of the neuromuscular junction in mice with deleted exons 5 and 6 of acetylcholinesterase
    Emmanuelle Girard
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, UPR 9040, CNRS, 91198 Gif sur Yvette Cedex, France
    J Mol Neurosci 30:99-100. 2006
    ..skeletal neuromuscular junction (NMJ), two closely related enzymes can hydrolyze acetylcholine (ACh): acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)...
  79. doi Antioxidant and acetylcholinesterase response to repeated malathion exposure in rat cerebral cortex and hippocampus
    Rafael Trevisan
    Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil
    Basic Clin Pharmacol Toxicol 102:365-9. 2008
    ..Some reports have shown that low doses of malathion, in a repeated treatment regimen, are unable to reduce acetylcholinesterase (AChE) activity in the rat brain, in contrast to the inhibitory effect in acute treatment...
  80. pmc Analysis of the reaction of carbachol with acetylcholinesterase using thioflavin T as a coupled fluorescence reporter
    Terrone L Rosenberry
    Mayo Clinic College of Medicine, Department of Neuroscience, Jacksonville, Florida 32224, USA
    Biochemistry 47:13056-63. 2008
    b>Acetylcholinesterase (AChE) contains a narrow and deep active site gorge with two sites of ligand binding, an acylation site (or A-site) at the base of the gorge and a peripheral site (or P-site) near the gorge entrance...
  81. ncbi Distribution of acetylcholinesterase activity in the deutocerebrum of the sphinx moth Manduca sexta
    U Homberg
    Institut fur Zoologie, Universitat Regensburg, Germany
    Cell Tissue Res 279:249-59. 1995
    We have used a cytochemical technique to investigate the distribution of acetylcholinesterase (AChE) activity in the deutocerebrum of the brain of the sphinx moth Manduca sexta...
  82. pmc Acetylcholinesterase of Schistosoma mansoni--functional correlates. Contributed in honor of Professor Hans Neurath's 90th birthday
    R Arnon
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Protein Sci 8:2553-61. 1999
    b>Acetylcholinesterase (AChE) is an enzyme broadly distributed in many species, including parasites. It occurs in multiple molecular forms that differ in their quaternary structure and mode of anchoring to the cell surface...
  83. ncbi Delivery of human acetylcholinesterase by adeno-associated virus to the acetylcholinesterase knockout mouse
    Anna Hrabovska
    Eppley Institute, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Chem Biol Interact 157:71-8. 2005
    The purpose of this work was to develop a gene delivery system that expressed acetylcholinesterase (AChE) for prolonged periods...
  84. doi In silico pharmacophore model for tabun-inhibited acetylcholinesterase reactivators: a study of their stereoelectronic properties
    Apurba K Bhattacharjee
    Department of Regulated Laboratories, Division of Regulated Activities, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, USA
    Chem Res Toxicol 23:26-36. 2010
    Organophosphorus (OP) nerve agents that inhibit acetylcholinesterase (AChE; EC 3.1.1.7) function in the nervous system, causing acute intoxication. If untreated, death can result...
  85. ncbi Body size-related differences in the inhibition of brain acetylcholinesterase activity in juvenile Nile tilapia (Oreochromis niloticus) by chlorpyrifos and carbosulfan
    L W H U Chandrasekara
    Department of Zoology, University of Kelaniya, Kelaniya, Sri Lanka
    Ecotoxicol Environ Saf 67:109-19. 2007
    Influence of body size on inhibition of brain acetylcholinesterase (AChE) activity of juvenile Nile tilapia, Oreochromis niloticus by chlorpyrifos and carbosulfan was investigated concerning its potential use in the biomonitoring of ..
  86. ncbi SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylcholinesterase inhibitors: synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues
    M Recanatini
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, I 40126 Bologna, Italy
    J Med Chem 43:2007-18. 2000
    In this study, we attempted to derive a comprehensive SAR picture for the class of acetylcholinesterase (AChE) inhibitors related to tacrine, a drug currently in use for the treatment of the Alzheimer's disease...
  87. ncbi Characterization of reversible and pseudo-irreversible acetylcholinesterase inhibitors by means of an immobilized enzyme reactor
    Manuela Bartolini
    Department of Pharmaceutical Sciences, Via Belmeloro 6, University of Bologna, 40126 Bologna, Italy
    J Chromatogr A 1144:102-10. 2007
    The aim of the present study was the application of a human AChE-CIM-IMER (enzyme reactor containing acetylcholinesterase immobilized on a monolithic disk) for the rapid evaluation of the thermodynamic and kinetic constants, and the ..
  88. ncbi Regulation of acetylcholinesterase expression by calcium signaling during calcium ionophore A23187- and thapsigargin-induced apoptosis
    Hui Zhu
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
    Int J Biochem Cell Biol 39:93-108. 2007
    We have recently reported that acetylcholinesterase expression was induced during apoptosis in various cell types...
  89. pmc Screening the methanol extracts of some Iranian plants for acetylcholinesterase inhibitory activity
    A Gholamhoseinian
    Department of Biochemistry, Medical School and Kerman Physiology Research Center, Kerman University of Medical Sciences, Kerman, I R Iran
    Res Pharm Sci 4:105-12. 2009
    b>Acetylcholinesterase (AChE) is the main enzyme for the breakdown of acetylcholine...
  90. ncbi [Recovery of Chlamydia pneumoniae and Chlamydia trachomatis in a patient with recurrent tonsillitis, bronchitis and otitis media with effusion]
    H Ogawa
    Ear, Nose and Throat Clinic, Kitasato Institute Hospital
    Kansenshogaku Zasshi 65:234-8. 1991
    ..trachomatis had disappeared from the middle-ear effusion, but C. pneumoniae was recovered from both tonsillar and bronchial swabs. Readministration of rokitamycin was performed and to date (June, 1990) she remains well...
  91. pmc Replacement of the glycoinositol phospholipid anchor of Drosophila acetylcholinesterase with a transmembrane domain does not alter sorting in neurons and epithelia but results in behavioral defects
    J P Incardona
    Department of Genetics, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106, USA
    Mol Biol Cell 7:613-30. 1996
    Drosophila has a single glycoinositol phospholipid (GPI)-anchored form of acetylcholinesterase (AChE) encoded by the Ace locus...
  92. pmc The acetylcholinesterase inhibitor rivastigmine does not alter total choices for methamphetamine, but may reduce positive subjective effects, in a laboratory model of intravenous self-administration in human volunteers
    R De La Garza
    David Geffen School of Medicine at the University of California Los Angeles, Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA, United States
    Pharmacol Biochem Behav 89:200-8. 2008
    ..We conducted a double-blind, placebo-controlled, between groups investigation of the acetylcholinesterase (AChE) inhibitor rivastigmine in non-treatment-seeking volunteers who met criteria for methamphetamine ..
  93. ncbi A steric blockade model for inhibition of acetylcholinesterase by peripheral site ligands and substrate
    T L Rosenberry
    Department of Pharmacology, Mayo Clinic Jacksonville, FL 32224, USA
    Chem Biol Interact 119:85-97. 1999
    The active site gorge of acetylcholinesterase (AChE) contains two sites of ligand binding, an acylation site near the base of the gorge and a peripheral site at its mouth...
  94. ncbi Differential expression of acetylcholinesterase in the brainstem, ventrobasal thalamus and primary somatosensory cortex of perinatal rats, mice, and hamsters
    C A Bennett-Clarke
    Department of Anatomy and Neurobiology, Medical College of Ohio, Toledo 43699, USA
    Somatosens Mot Res 16:269-79. 1999
    b>Acetylcholinesterase (AChE) is transiently expressed by thalamocortical axons in the rat, and staining for this enzyme has been used extensively to study the development of thalamocortical projections...
  95. doi Transgenic mice overexpressing human acetylcholinesterase and the Swedish amyloid precursor protein mutation: effect of nicotine treatment
    M M Hedberg
    Karolinska Institutet, Department of Neurobiology Care Sciences and Society, Division of Alzheimer Neurobiology, Karolinska University Hospital, Huddinge, Novum 5th floor, S 141 86 Stockholm, Sweden
    Neuroscience 152:223-33. 2008
    b>Acetylcholinesterase (AChE) is shown to promote deposition of beta-amyloid (Abeta) peptides and to enhance Abeta toxicity...
  96. ncbi A new rapid acetylcholinesterase histochemical method for the intraoperative diagnosis of Hirschsprung's disease and intestinal neuronal dysplasia
    G Martucciello
    Department and Chair of Pediatric Surgery, Giannina Gaslini Children s Hospital University of Genova, Genova, Italy
    Eur J Pediatr Surg 11:300-4. 2001
    The most commonly used acetylcholinesterase (AChE) method for the diagnosis of Hirschsprung's disease (HD) and intestinal neuronal dysplasia (IND) was first introduced in 1964 by Morris Karnovsky and Logan Roots...
  97. ncbi Differential effects of TAK-802, a selective acetylcholinesterase inhibitor, and carbamate acetylcholinesterase inhibitors on contraction of the detrusor smooth muscle of the guinea pig
    Hiroshi Nagabukuro
    Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 2 17 85, Jusohonmachi, Osaka, 532 8686, Japan
    Life Sci 77:3276-86. 2005
    The aim of this study was to compare the effects of TAK-802, a novel acetylcholinesterase (AChE) inhibitor, and carbamate AChE inhibitors on the detrusor smooth muscle contractility in vitro using isometric tension measurements...
  98. doi Acetylcholinesterase activity and lipid peroxidation in the brain and spinal cord of rats infected with Trypanosoma evansi
    Aleksandro S Da Silva
    Department of Microbiology and Parasitology, Universidade Federal de Santa Maria, Brazil aleksandro
    Vet Parasitol 175:237-44. 2011
    ..Therefore, changes in acetylcholinesterase (AChE) activity and lipid peroxidation in brain and spinal cord of T...
  99. ncbi Glycine effects on glutamate-receptor elicited acetylcholinesterase release from slices and synaptosomes of the spinal ventral horn
    D Rodriguez-Ithurralde
    Laboratory of Molecular Neuroscience, Instituto de Investigaciones Biológicas Clemente Estable IIBCE, Montevideo, Uruguay
    J Neurol Sci 139:76-82. 1996
    To study the mechanisms by which glutamate-elicited acetylcholinesterase release (GEAR) might play a part in the pathogenesis of excitotoxically triggered motor neurone disease, and to investigate the interaction of GEAR with spinal ..
  100. ncbi In vivo inhibition of acetylcholinesterase activity in functionally different tissues of the freshwater fish, Cyprinus carpio, under chlorpyrifos exposure
    Ramesh Halappa
    Environmental and Molecular Toxicology Division, Department of Zoology, Karnatak University s Karnatak Science College, Dharwad, Karnataka, India
    Drug Metabol Drug Interact 24:123-36. 2009
    The inhibitory effect of chlorpyrifos on acetylcholinesterase (AChE) activity in different concentrations and exposure periods was investigated in the fish, Cyprinus carpio. Sublethal concentrations 14% (0.0224 mg/l) and 7% (0...
  101. ncbi Acetylcholinesterase activity in chronic renal failure
    Y G Prall
    Department of Biology, Howard University, Washington, DC 20059, USA
    Life Sci 66:835-45. 2000
    ..CRF-patients) maintained on chronic hemodialysis were used in this investigation to study the changes in acetylcholinesterase (AChE) activity of red blood cells (RBCs). The CRF-patients were all undergoing hemodialysis treatment...

Research Grants68

  1. Central cholinergic function in AChE-deficient mice
    Jochen Klein; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Acetylcholinesterase (ACHE) is the enzyme which is responsible for the breakdown of the neurotransmitter, acetylcholine (ACh), in cholinergic synapses...
  2. KENNETH W GRASING; Fiscal Year: 2015
    ..Mammalian brain contains two forms of cholinesterase, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE)...
  3. Tacrine Effects on Cocaine Self-Administration and Pharmacokinetic Measures
    KENNETH W GRASING; Fiscal Year: 2012
    ..Cholinesterase inhibitors such as tacrine increase synaptic levels of ACh by preventing its inactivation by acetylcholinesterase (AChE) or butyrylcholinesterase (BuChE), and can improve learning and memory...
  4. Cholinesterase Inhibitors in Alzheimer's Disease
    Debomoy K Lahiri; Fiscal Year: 2012
    ..Our goal is to test novel acetylcholinesterase inhibitors (AChEIs) or butyrylcholinesterase inhibitors (BChEIs) against pivotal steps in the ..
  5. Pope-Presynaptic modulation of anticholinesterase toxicity
    Carey N Pope; Fiscal Year: 2013
    Organophosphorus insecticides (OPs) elicit toxicity by inhibiting acetylcholinesterase, leading to acetylcholine accumulation at cholinergic synapses, excessive stimulation of cholinergic receptors and signs of acute toxicity (e.g...
  6. REBECCA ASHARE; Fiscal Year: 2016
    ..designed to examine the effects on smoking cessation of a novel pharmacological treatment, galantamine, an acetylcholinesterase inhibitor (ACHEI) that is FDA-approved to treat the cognitive symptoms of Alzheimer's disease...
  7. Restoration of Estradiol Effects on Learning by Cholinergic Enhancement
    Robert Gibbs; Fiscal Year: 2009
    ..Levels of choline acetyltransferase and acetylcholinesterase activities in the hippocampus and frontal cortex also will be measured as indices of the degree of ..
  8. A Plant-Derived Recombinant Bioscavenger to Prevent Insecticide Neurotoxicity
    Yvonne Rosenberg; Fiscal Year: 2007
    ..Inhibition of the targeted acetylcholinesterase (AChE) by OP insecticides may be prevented by high levels of serum butyrylcholinesterase (BChE) which is a ..
  9. Age and sex effects on nerve agent damage to the brain and antidotal therapies
    Edson X Albuquerque; Fiscal Year: 2010
    ..Most of their acute toxicity results from the irreversible inhibition of acetylcholinesterase (AChE), the enzyme that inactivates the endogenous neurotransmitter acetylcholine...
  10. Next Generation Oxime Therapeutic for Chemical Agent Inhibited CNS (Brain) ChEs
    Richard K Gordon; Fiscal Year: 2010
    ..blood brain barrier (BBS), removal of excessive accumulation of acetylcholine (ACh) is not accomplished by acetylcholinesterase (AChE). Pesticides and OPs are significant terrorist threats to civilian populations...
  11. Optimization of nonpyridinium oximes for BChE hydrolysis of OPs in plasma
    PALMER WILLIAM TAYLOR; Fiscal Year: 2012
    ..atropine combination therapy is inefficient for treatment of higher exposure OP poisoning due to constant acetylcholinesterase (AChE) reinhibition by excess OP...
  12. Enhanced bioscavenger for medical countermeasures against organophosphorus agents
    Zhiguo Zhou; Fiscal Year: 2013
    ..OP's act on acetylcholinesterase to prevent synaptic inactivation, thereby leading to immobilization and death on sustained application...
  13. Asthma Exacerbation by Organophosphate Pesticides
    ALLISON DEBORAH FRYER; Fiscal Year: 2011
    ..that normally limit acetylcholine release, and occurs at doses significantly lower than those that inhibit acetylcholinesterase. Here we show that sensitized animals (sensitized to an antigen but never challenged with antigen) are ..
  14. Multi-targeted Countermeasures against Acute and Delayed Effects of OP Exposure
    John A Butera; Fiscal Year: 2013
    ..Their toxicity is principally due to their ability to irreversibly bind to acetylcholinesterase (AChE) in the CNS and blood...
  15. Intranasal CNS delivery of drugs against organophosphorous threat agents
    ARYAN MANGALAM NAMBOODIRI; Fiscal Year: 2013
    ..CTAs exert their toxic effects by inhibiting acetylcholinesterase (AChE) leading to the accumulation of acetylcholine at synaptic and neuromuscular junctions leading to ..
  16. John H McDonough; Fiscal Year: 2016
    ..the current standard of care (SOC) therapies (United States) of acetylcholine receptor blocker atropine, acetylcholinesterase (AChE) reactivator pralidoxime (2-[(hydroxyimino)methyl]-1-methylpyridinium, 2-PAM), and symptom modulator ..
  17. The Impact of Genetic Variability on Human Susceptibility to Chlorpyrifos
    ALICE LANGFORD CRANE; Fiscal Year: 2013
    ..These compounds inhibit the enzymes acetylcholinesterase (AChE) and butylrylcholinesterase (BChE)...
  18. Stuart D Katz; Fiscal Year: 2014
    ..b>Acetylcholinesterase inhibitors augment parasympathetic neurotransmission by blocking the enzymatic breakdown of acetylcholine ..
  19. Rivastigmine and Huperzine A as Potential Treatments for Cocaine Addiction
    Richard De La Garza; Fiscal Year: 2012
    ..shown the importance of muscarinic ACh receptors in cocaine reinforced- and non-reinforced-responding, and acetylcholinesterase (AChE) inhibitors reduced methamphetamine-seeking behavior in rodents...
  20. NEURAL & PHARMACOLOGICAL CONTROL OF AIRWAY SMOOTH MUSCLE
    Richard Mitchell; Fiscal Year: 1991
    ..could be mimicked in muscle strips by addition of small concentrations of acetylcholine or by inhibiting acetylcholinesterase. These studies indicated possible presynaptic augmentation of acetylcholine release and/or reduced ..
  21. ACETYLCHOLINESTERASE-CATALYZED HYDROLYSIS
    Daniel Quinn; Fiscal Year: 1991
    b>Acetylcholinesterase (AChE) is an enzyme with rich biomedical, pharmacological and toxicological history. This is undoubtedly due to the central role tat AChE plays, along with the ACh receptor, in cholinergic neurotransmission...
  22. AGENTS FOR THE TREATMENT OF MEMORY & LEARNING DISORDERS
    Alan Kozikowski; Fiscal Year: 1993
    ..We are optimistic that a useful, more effective, and less toxic acetylcholinesterase (AChE) inhibitor than those currently available can be identified for clinical use...
  23. PROTECTION AGAINST ORGANOPHOSPHATE NEUROTOXINS BY TOBACCO CEMBRANOIDS
    P A Ferchmin; Fiscal Year: 2010
    ..OPs inhibit the acetylcholinesterase (AChE) in brain and peripheral nerves, causing a cholinergic crisis that is fatal if untreated...
  24. Development of vector-specific, resistance-breaking insecticides to reduce malari
    Paul R Carlier; Fiscal Year: 2013
    ..Our broad objective is to develop a new class of acetylcholinesterase (AChE)-targeting insecticide for deployment on ITNs, that is safe for use, effective against current ..
  25. A NEW BIOSENSOR BASED ON CATASTROPHIC PROTEIN CHANGES
    CHARLES MARK THOMPSON; Fiscal Year: 2010
    ..This concept will be tested and proven using recombinant acetylcholinesterase (AChE) an enzyme that is known to undergo catastrophic denaturation when it reacts with organophosphate (OP)..
  26. Nanoparticle Defense for Agrichemical Exposures
    CHARLES MARK THOMPSON; Fiscal Year: 2012
    ..which the membrane of a polymerized liposome nanoparticle (PLN) displays functional acetylcholinesterase, the primary target for OPs, while a therapeutic cargo is encapsulated (e.g., oxime)...
  27. REVERSING THE EFFECTS OF ORGANOPHOSPHORUS PESTICIDES
    RON BRADLEY; Fiscal Year: 1990
    b>Acetylcholinesterase inhibitors used as insecticides, nematocides, acaricides, fungicides, etc., present a considerable environmental hazard to the health of agricultural workers and others...
  28. RESEARCH CAREER DEVELOPMENT IN BIOCHEMICAL TOXICOLOGY
    Janice Chambers; Fiscal Year: 1993
    ..is on concepts related to the acute toxicity of organophosphorus insecticides, which act by inhibiting acetylcholinesterase (AChE)...
  29. KINETICS OF DRUG MACROMOLECULE COMPLEX FORMATION
    PALMER WILLIAM TAYLOR; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Our continuing investigation of acetylcholinesterase (AChE), the acetylcholine binding protein (AChBP) reflect a long standing and continuous commitment to the study of proteins that affect the ..
  30. RICARDO ANIBAL MASELLI; Fiscal Year: 2014
    ..encoding the adult acetylcholine receptor (AChR) subunit genes (CHRNA1, CHRNB1, CHRND, CHRNE), and the acetylcholinesterase (AChE) collagenic tail (COLQ) were shown to cause several forms of CMS...
  31. Katumi Sumikawa; Fiscal Year: 2014
    ..The effect of nicotine on NMDAR is mimicked by anti-acetylcholinesterase drugs for Alzheimer's disease and prevented by coadministration of a muscarinic receptor antagonist...
  32. Organophosphate Action in the Central Nervous System
    NEIL MARC NATHANSON; Fiscal Year: 2012
    Organophosphate (OP) acetylcholinesterase inhibitors are used widely in agriculture as pesticides and also have been used in terrorist attacks against civilian populations...
  33. Fullerenes Counteracting Organophosphorus Threats
    Marion F Ehrich; Fiscal Year: 2010
    ..agents used as agents of terror include organophosphorus (OP) compounds, neurotoxic substances that inhibit acetylcholinesterase (AChE) activity. When the neurotransmitter acetylcholine is not destroyed cholinergic poisoning can result...
  34. Neonatal Methamphetamine Effects on Adult Cholinergic and Cognitive Function
    Jessica A Siegel; Fiscal Year: 2010
    ..in adulthood using muscarinic acetylcholine receptor binding assays;and 3) determine the ability of the acetylcholinesterase inhibitor rivastigmine or the muscarinic receptor agonist carbachol, injected directly into the lateral ..
  35. Melissa A Harrington; Fiscal Year: 2015
    ..and investigate how contact with muscle cells, the formation of neuromuscular junctions, and possibly acetylcholinesterase influence the neurotransmitter released...
  36. "Development of Drugs to Mitigate Parathion Intoxication"
    Jeffrey D Laskin; Fiscal Year: 2012
    ..A major site of action for paraoxon is the enzyme acetylcholinesterase;proper functioning of this enzyme is crucial for normal nerve cell activity and its inhibition can be fatal...
  37. CutA interacts with BACE1 and participates in Alzheimer's disease
    Yunwu Zhang; Fiscal Year: 2012
    ..Previous studies suggest that CutA may regulate the level/activity of acetylcholinesterase (AChE), an enzyme that degrades acetylcholine and an important target of inhibition for current AD ..
  38. Jogeshwar Mukherjee; Fiscal Year: 2016
    ..This will be of great value to evaluate efficacy of acetylcholinesterase inhibitors used in AD...
  39. Counteracting acute and persistent effects of OP intoxication by endocannabinoids
    Carey N Pope; Fiscal Year: 2011
    ..While substantial evidence indicates that non-cholinergic signaling is "recruited" following acetylcholinesterase inhibition and plays a role in long-term neurological deficits, involvement of other signaling pathways is ..
  40. Andrew J Waters; Fiscal Year: 2014
    ..GAL enhances cholinergic transmission by inhibiting acetylcholinesterase, the enzyme that breaks down acetylcholine...
  41. Investigations Targeting Symptomatic Relief to Botulinum Neurotoxin A Intoxicatio
    Kim D Janda; Fiscal Year: 2013
    ..when administered will promote acetylcholine release and ones that will promote both acetylcholine release/acetylcholinesterase inhibition, in other words poly-functional intervention...
  42. Modeling cholinergic modulation of fMRI memory networks in aging & MCI
    Alireza Atri; Fiscal Year: 2010
    ..b>Acetylcholinesterase inhibitors (AChEl) produce modest overall benefits in AD but their effects in MCI are less clear...
  43. Christos Constantinidis; Fiscal Year: 2016
    ..Cholinergic drugs (acetylcholine agonists and acetylcholinesterase inhibitors) can reverse these symptoms...
  44. Steven B Bird; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The acute toxicity of OPs is primarily due to inhibition of acetylcholinesterase (AChE)...
  45. Novel Neuromuscular Protection to CounterACT Organophosphorus (OP) Poisoning
    Steven B Bird; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The acute toxicity of OPs is primarily due to inhibition of acetylcholinesterase (AChE)...
  46. Synthesis of methylating ligands that reactivate aged acetylcholinesterase
    DANIEL M QUINN; Fiscal Year: 2012
    ..such as sarin and soman, are acutely toxic compounds that act by inhibiting the activity of the enzyme acetylcholinesterase (AChE) at nerve-nerve and neuromuscular junctions in the central and peripheral nervous systems, ..
  47. IMPROVED EXPOSURE ASSESSMENT FOR ORGANOPHOSPHATE PESTICI
    GARRETT KEATING; Fiscal Year: 2001
    ..proposed research is to improve exposure assessment of pesticides by developing a methodology for measuring acetylcholinesterase (AChE) inhibition that includes determinations of free and total enzyme in the same blood sample...
  48. Rivastigmine as a Treatment for Methamphetamine Dependence
    Richard De La Garza; Fiscal Year: 2010
    ..a double-blind placebocontrolled human laboratory study demonstrating that treatment with a 3mg dose of the acetylcholinesterase (AChE) inhibitor rivastigmine significantly attenuated MA-induced craving...
  49. Phospholipid flip-flop in biogenic membranes
    Anant K Menon; Fiscal Year: 2013
    ..molecules include glycoproteins such as the neural cell adhesion molecule, GPI-anchored proteins such as acetylcholinesterase, glycolipids such as the receptor for cholera toxin, components of the cell walls of bacteria and yeast, ..
  50. Protection against sarin-induced neurotoxicity via an in vivo caspase inhibitor
    David R Cool; Fiscal Year: 2011
    ..for CWA organophosphate exposure is a specialized drug combination containing;a drug to regenerate acetylcholinesterase activity;and two drugs to prevent seizures...
  51. VALENTIN ATANASSOV PAVLOV; Fiscal Year: 2014
    ..We have also recently shown that galantamine, a centrally-acting acetylcholinesterase (AChE) inhibitor suppresses systemic TNF levels and improves survival in endotoxemia through brain ..
  52. Structural Analysis of the GPI Transamidase Complex
    Anant K Menon; Fiscal Year: 2012
    ..Examples of GPI-APs include folate receptor, acetylcholinesterase, renal dipeptidase and the variant surface glycoproteins of Trypanosoma brucei, the causative agent of ..
  53. RICHARD LEE ROTUNDO; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Acetylcholinesterase (AChE), the enzyme that terminates cholinergic transmission in the nervous system, is the target of organophosphate nerve agents and pesticides...
  54. Donepezil to promote functional recovery post-stroke
    Ellen M Whyte; Fiscal Year: 2013
    ..Recent evidence indicates that acetylcholinesterase inhibitors may improve cognition and motivation;hence, their use post-stroke may lead to improved ..
  55. The neurogenic potential of cholinergic activation in AD.
    ELIZABETH ADAMS ECKMAN; Fiscal Year: 2013
    ..drugs to treat AD rely on attempting to increase this cholinergic transmission by blocking a key enzyme, acetylcholinesterase. The efficacy of the drugs is limited, however, and when the cells eventually die the drugs are no longer ..
  56. Richard Nowak; Fiscal Year: 2016
    ..Treatment consists of symptomatic therapy with acetylcholinesterase inhibitors and immunotherapy such as corticosteroids, azathioprine, cyclosporine, and plasma exchange (PLEX)..
  57. Environmental Enrichment and Cholinergic Mechanisms after TBI
    Anthony E Kline; Fiscal Year: 2013
    ..assess the effect of a delayed and chronic treatment regimen (1-20 days post-injury) with the FDA-approved acetylcholinesterase inhibitor donepezil in male and both intact and OVX female rats after TBI to determine if motor and ..
  58. Jason R Richardson; Fiscal Year: 2016
    ..We have further demonstrated that our drug is effective in reducing parathion-induced inhibition of brain acetylcholinesterase activity...
  59. Cognitive Neurorehabilitation to Enhance Recovery After Stroke
    DeAnna L Adkins; Fiscal Year: 2010
    ..the hippocampus compared to non-trained groups;3) Coupling cognitive neurorehabilitative training with an acetylcholinesterase inhibitor will enhance the efficacy of post-stroke cognitive neurorehabilitation...
  60. Genetic Resource for Assaying Neuropeptide Function in vivo
    AMY BETH VASHLISHAN MURRAY; Fiscal Year: 2012
    ..both endogenous and ectopically expressed neuropeptides in response to muscle contraction induced by the acetylcholinesterase inhibitor aldicarb...
  61. Phase III Study of Donepezil in the Irradiated Brain
    Stephen R Rapp; Fiscal Year: 2010
    ..Administration of selective inhibitors of acetylcholinesterase like donepezil (Aricept) has proven effective in improving neurocognitive functioning and behavioral ..
  62. Jennifer D Thomas; Fiscal Year: 2015
    ..Secondly, we will examine whether administration of donepezil, an acetylcholinesterase inhibitor which also increases cholinergic activity, can improve cognitive performance following early ..
  63. C-N Bond-Forming Methodologies for the Synthesis of Small Molecules and Peptides
    JENNIFER LYNN STOCKDILL; Fiscal Year: 2012
    ..This method will enable rapid access to the recently isolated acetylcholinesterase inhibitor lycojapodine A...
  64. Mixture Modeling: Pesticide Drug Interactions
    Charles Timchalk; Fiscal Year: 2009
    ..The mode of action for organophosphorus insecticides involves their capacity to inhibit acetylcholinesterase (AChE) activity resulting in the accumulation of acetylcholine within the cholinergic synapse thereby ..
  65. Organophosphorus Pesticide Toxicology
    JOHN CASIDA; Fiscal Year: 2006
    ..The two principal targets of OP toxicant action are acetylcholinesterase (AChE) for acute toxicity and neuropathy target esterase (NTE) for OP-induced delayed neuropathy (OPIDN)...
  66. DEVELOPMENTAL NEUROTOXICITY OF OP INSECTICIDES
    Janice Chambers; Fiscal Year: 2006
    ..The mechanism of toxicity, inhibition of acetylcholinesterase (AChE), causes hyperactivity in cholinergic pathways, which can elicit compensatory neurochemical ..
  67. NEW MUSCARINIC AGENTS--SELECTIVITY OF ACTION
    Frank Carroll; Fiscal Year: 1990
    ..g., arecoline) or indirectly by inhibition of acetylcholinesterase (AChE) (e.g., physostigmine) can enhance performance...
  68. EXCITOTOXIN EFFECTS ON SPINAL CORD IN VITRO
    JOHN DELFS; Fiscal Year: 1992
    ..cholinergic systems will be assessed by histological and morphometric analysis after staining cultures for acetylcholinesterase activity (AChE) and choline acetyltransferase (CHAT) - immunoreactivity, and by biochemical analysis of ..