ACE

Summary

Gene Symbol: ACE
Description: angiotensin I converting enzyme
Alias: ACE1, CD143, DCP, DCP1, angiotensin-converting enzyme, CD143 antigen, angiotensin I converting enzyme (peptidyl-dipeptidase A) 1, angiotensin converting enzyme, somatic isoform, carboxycathepsin, dipeptidyl carboxypeptidase 1, dipeptidyl carboxypeptidase I, kininase II, peptidase P
Species: human

Top Publications

  1. ncbi A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9
    M Donoghue
    Millennium Pharmaceuticals, Inc, Cambridge, MA 02139, USA
    Circ Res 87:E1-9. 2000
  2. doi A genome-wide association study identifies new loci for ACE activity: potential implications for response to ACE inhibitor
    C M Chung
    Division of Molecular Medicine, Institute of Public Health, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Pharmacogenomics J 10:537-44. 2010
  3. pmc Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning
    F Soubrier
    Institut National de la Sante et de la Recherche Medicale, Unite 36, Paris, France
    Proc Natl Acad Sci U S A 85:9386-90. 1988
  4. pmc RAS gene polymorphisms, classical risk factors and the advent of coronary artery disease in the Portuguese population
    Ana I Freitas
    Human Genetics Laboratory, University of Madeira, Portugal
    BMC Cardiovasc Disord 8:15. 2008
  5. doi Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough
    Antonio Grilo
    Unidad de Hipertension, Servicio de Medicina Interna, Hospital Universitario de Valme, Carretera de Cádiz S N bNeocodex, Avda, Charles Darwin, Acc A Seville, Spain
    Pharmacogenet Genomics 21:10-7. 2011
  6. ncbi ACE gene insertion/deletion polymorphism in childhood idiopathic nephrotic syndrome
    Erkin Serdaroglu
    Department of Pediatric Nephrology, Ege University Medical School, Izmir, Turkey
    Pediatr Nephrol 20:1738-43. 2005
  7. doi Association of angiotensinogen gene M235T and angiotensin-converting enzyme gene I/D polymorphisms with essential hypertension in Han Chinese population: a meta-analysis
    Lin dan Ji
    Department of Biochemistry and Genetics, School of Medicine, Zhejiang University, Hangzhou, PR China
    J Hypertens 28:419-28. 2010
  8. ncbi Renin-angiotensin system gene polymorphisms and coronary artery disease in a large angiographic cohort: detection of high order gene-gene interaction
    Chia Ti Tsai
    Division of Cardiology, Department of Internal Medicine, National Taiwan, University Hospital, Taipei, Taiwan
    Atherosclerosis 195:172-80. 2007
  9. pmc Causal relationship of susceptibility genes to ischemic stroke: comparison to ischemic heart disease and biochemical determinants
    Paul Bentley
    Imperial College Cerebrovascular Research Unit, Clinical Neurosciences, Charing Cross Hospital, Imperial College London, London, United Kingdom
    PLoS ONE 5:e9136. 2010
  10. ncbi Sequence variation in the human angiotensin converting enzyme
    M J Rieder
    University of Washington, Department of Molecular Biotechnology, Seattle 98195, USA
    Nat Genet 22:59-62. 1999

Research Grants

  1. JAMES MATTHEW LUTHER; Fiscal Year: 2016
  2. Role of the Renin-Angiotensin system in placental insufficiency
    Eugenia Mata-Greenwood; Fiscal Year: 2013
  3. 2010 Angiotensin Gordon Research Conference
    Kathy K Griendling; Fiscal Year: 2010
  4. Vitamin D Deficiency Augments Renin-Angiotensin System Activity in Obesity
    Anand Vaidya; Fiscal Year: 2011
  5. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
  6. ACE and ACE2 in Glomerular Angiotensin Peptides Metabolism
    JAN ANDRZEJ WYSOCKI; Fiscal Year: 2010
  7. NAHID JAMAL RIANON; Fiscal Year: 2014
  8. Genome-wide case-only study of antihypertensive drug-gene interactions
    Bruce M Psaty; Fiscal Year: 2010
  9. Pravin C Singhal; Fiscal Year: 2014
  10. STATINS AND ACE INHIBITORS IN ADULTS WITH DIABETES AND COMORBID CONDITIONS
    David E Grembowski; Fiscal Year: 2010

Patents

  1. NUCLEIC ACID CODING FOR THE HUMAN TESTICULAR ANGIOTENSIN CONVERSION ENZYME (ECA) AND ITS APPLICATIONS, IN PARTICULAR FOR THE IN VITRO DETECTION OF SAID ENZYME IN THE ORGANISM

Detail Information

Publications406 found, 100 shown here

  1. ncbi A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9
    M Donoghue
    Millennium Pharmaceuticals, Inc, Cambridge, MA 02139, USA
    Circ Res 87:E1-9. 2000
    ACE2, the first known human homologue of angiotensin-converting enzyme (ACE), was identified from 5' sequencing of a human heart failure ventricle cDNA library...
  2. doi A genome-wide association study identifies new loci for ACE activity: potential implications for response to ACE inhibitor
    C M Chung
    Division of Molecular Medicine, Institute of Public Health, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Pharmacogenomics J 10:537-44. 2010
    Because angiotensin-converting enzyme (ACE) activity is implicated widely in biological systems, we aimed to identify its novel quantitative trait loci for the purposes of understanding ACE activity regulation and pharmacogenetics ..
  3. pmc Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning
    F Soubrier
    Institut National de la Sante et de la Recherche Medicale, Unite 36, Paris, France
    Proc Natl Acad Sci U S A 85:9386-90. 1988
    ..and several internal peptide sequences of angiotensin I-converting enzyme (ACE; peptidyl-dipeptidase A, kininase II; EC 3.4.15.1) purified from human kidney were used to design oligonucleotide probes...
  4. pmc RAS gene polymorphisms, classical risk factors and the advent of coronary artery disease in the Portuguese population
    Ana I Freitas
    Human Genetics Laboratory, University of Madeira, Portugal
    BMC Cardiovasc Disord 8:15. 2008
    ....
  5. doi Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough
    Antonio Grilo
    Unidad de Hipertension, Servicio de Medicina Interna, Hospital Universitario de Valme, Carretera de Cádiz S N bNeocodex, Avda, Charles Darwin, Acc A Seville, Spain
    Pharmacogenet Genomics 21:10-7. 2011
    ..However, relatively little is known about the genetic susceptibility to ACEi-induced cough in hypertensive patients...
  6. ncbi ACE gene insertion/deletion polymorphism in childhood idiopathic nephrotic syndrome
    Erkin Serdaroglu
    Department of Pediatric Nephrology, Ege University Medical School, Izmir, Turkey
    Pediatr Nephrol 20:1738-43. 2005
    The aim of this study was to determine the distribution of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism, and its effects on clinical, laboratory, histological findings, treatment responses and ..
  7. doi Association of angiotensinogen gene M235T and angiotensin-converting enzyme gene I/D polymorphisms with essential hypertension in Han Chinese population: a meta-analysis
    Lin dan Ji
    Department of Biochemistry and Genetics, School of Medicine, Zhejiang University, Hangzhou, PR China
    J Hypertens 28:419-28. 2010
    The polymorphisms of angiotensinogen (AGT) and angiotensin-converting enzyme (ACE) genes have been linked to increased risk of essential hypertension in multiple populations, but the results were inconsistent.
  8. ncbi Renin-angiotensin system gene polymorphisms and coronary artery disease in a large angiographic cohort: detection of high order gene-gene interaction
    Chia Ti Tsai
    Division of Cardiology, Department of Internal Medicine, National Taiwan, University Hospital, Taipei, Taiwan
    Atherosclerosis 195:172-80. 2007
    ..16 genotype disequilibria exclusively found in the controls, all of which included at least two genes among AGT, ACE and AT1R genes)...
  9. pmc Causal relationship of susceptibility genes to ischemic stroke: comparison to ischemic heart disease and biochemical determinants
    Paul Bentley
    Imperial College Cerebrovascular Research Unit, Clinical Neurosciences, Charing Cross Hospital, Imperial College London, London, United Kingdom
    PLoS ONE 5:e9136. 2010
    ..Meta-analyses demonstrated positive associations with ischemic stroke for factor V Leiden Gln506, ACE I/D, MTHFR C677T, prothrombin G20210A, PAI-1 5G allele and glycoprotein IIIa Leu33Pro polymorphisms (ORs: 1.11 - 1...
  10. ncbi Sequence variation in the human angiotensin converting enzyme
    M J Rieder
    University of Washington, Department of Molecular Biotechnology, Seattle 98195, USA
    Nat Genet 22:59-62. 1999
    b>Angiotensin converting enzyme (encoded by the gene DCP1, also known as ACE) catalyses the conversion of angiotensin I to the physiologically active peptide angiotensin II, which controls fluid-electrolyte balance and systemic blood ..
  11. ncbi The angiotensin converting enzyme I/D polymorphism in Russian athletes
    I B Nazarov
    Institute of Cytology of the Russian Academy of Sciences, Tikchoretski Ave 4, Saint Petersburg, 194064, Russia
    Eur J Hum Genet 9:797-801. 2001
    The deletion (D) allele of the human ACE gene is associated with higher ACE activity than the insertion (I) allele...
  12. ncbi Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme
    Ramanathan Natesh
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    Biochemistry 43:8718-24. 2004
    b>Angiotensin converting enzyme (ACE) plays a critical role in the circulating or endocrine renin-angiotensin system (RAS) as well as the local regulation that exists in tissues such as the myocardium and skeletal muscle...
  13. doi Angiotensin-converting enzyme insertion/deletion gene polymorphic variant as a marker of coronary artery disease: a meta-analysis
    Elias Zintzaras
    Center for Clinical Evidence Synthesis, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Arch Intern Med 168:1077-89. 2008
    Many studies have investigated the association between the angiotensin-converting enzyme (ACE) gene insertion (I)/deletion (D) polymorphic variant and coronary artery disease (CAD)...
  14. ncbi Angiotensin-converting enzyme gene polymorphism and carotid artery wall thickness: a meta-analysis
    Fakhredin A Sayed-Tabatabaei
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Stroke 34:1634-9. 2003
    Many studies have investigated the association between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and carotid artery intima-media thickness (IMT); however, most studies were small and conducted in ..
  15. ncbi Bradykinin receptor gene variant and human physical performance
    Alun G Williams
    Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College London Medical School, UK
    J Appl Physiol (1985) 96:938-42. 2004
    ..One such locus of influence is the gene for angiotensin-I converting enzyme (ACE), which exhibits a common variant [ACE insertion (I)/deletion (D)]...
  16. ncbi Possible synergic effect of angiotensin-I converting enzyme gene insertion/deletion polymorphism and angiotensin-II type-1 receptor 1166A/C gene polymorphism on ischemic heart disease in patients with Kawasaki disease
    Ryuji Fukazawa
    Department of Pediatrics, Nippon Medical School, 113 8603 Tokyo, Japan
    Pediatr Res 56:597-601. 2004
    b>ACE I/D and AT1R 1166A/C polymorphisms are considered to comprise individual risk factors for the development of coronary disease...
  17. ncbi ACE I allele and eNOS G allele crosstalk may have a role in chronic obstructive pulmonary disease
    Aarif Ahsan
    Functional Genomics Unit, Institute of Genomics and Integrative Biology, Delhi 110 007, India
    Clin Biochem 37:1037-40. 2004
    Pulmonary hypertension, a characteristic of chronic obstructive pulmonary disease (COPD) has led us to investigate polymorphisms in angiotensin-converting enzyme (ACE) and endothelial nitric oxide synthase (eNOS) genes.
  18. ncbi Reduction of pneumonia risk by an angiotensin I-converting enzyme inhibitor in elderly Japanese inpatients according to insertion/deletion polymorphism of the angiotensin I-converting enzyme gene
    Takashi Takahashi
    Department of General Medicine, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Am J Hypertens 18:1353-9. 2005
    We have reported that use of angiotensin I-converting enzyme (ACE) inhibitor, which is a class of antihypertensive agent that induces cough, is an independent factor in reducing risk of pneumonia among elderly inpatients...
  19. pmc Angiotensin-converting-enzyme gene polymorphisms, smoking and chronic obstructive pulmonary disease
    Xavier Busquets
    IUNICS Unitat d Investigació, University of Glasgow, Scotland, UK
    Int J Chron Obstruct Pulmon Dis 2:329-34. 2007
    ..We investigated the relationship between the insertion (I)--deletion (D) polymorphisms in the Angiotensin converting enzyme (ACE) gene and the risk of developing COPD in smokers by determining the distribution of the ACE ..
  20. ncbi Association between angiotensin converting enzyme (ACE) gene I/D polymorphism frequency and plasma ACE concentration in patients with idiopathic dilated cardiomyopathy
    Banu Kucukarabaci
    Anadolu Kardiyol Derg 8:65-6. 2008
  21. doi ACE gene polymorphism and cardiac structure in patients with insulin resistance
    Fulya Akin
    Faculty of Medicine, Department of Endocrinology and Metabolism, Pamukkale University, Kinikli Campus, 20070 Denizli, Turkey
    Mol Biol Rep 36:623-9. 2009
    Angiotensin-converting enzyme (ACE) is a key enzyme in the production of angiotensin II, thus may participate in the modulation of cardiac growth...
  22. doi A propensity score-based case-control study of renin-angiotensin system gene polymorphisms and diastolic heart failure
    Cho Kai Wu
    Department of Internal Medicine, National Taiwan University College of Medicine and Hospital Yun Lin Branch, Taiwan
    Atherosclerosis 205:497-502. 2009
    ..Genotyped were: the angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism; the T174M, M235T, G-6A, A-20C, G-152A and G-217A polymorphisms of the ..
  23. ncbi The ACE I/D polymorphism in elite Greek track and field athletes
    I D Papadimitriou
    Laboratory of Sports Biomechanics, Aristotle University, Serres, Greece
    J Sports Med Phys Fitness 49:459-63. 2009
    The aim of this study was to examine genetic differences among 101 elite Greek track and field athletes and a representative random control group of 181 Greek individuals, by analyzing the I/D polymorphism in exon 16 of the ACE gene.
  24. ncbi Angiotensin-converting enzyme insertion/deletion polymorphism associated with acute respiratory distress syndrome among caucasians
    Z Hu
    Intensive Care Unit, West China Hospital, Sichuan University, Chengdu, Sichuan, China
    J Int Med Res 38:415-22. 2010
    Studies investigating the association between angiotensin-converting enzyme (ACE) insertion/deletion polymorphisms and the risk of acute respiratory distress syndrome (ARDS) report conflicting results...
  25. pmc An angiotensin I-converting enzyme mutation (Y465D) causes a dramatic increase in blood ACE via accelerated ACE shedding
    Sergei M Danilov
    Department of Anesthesiology, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 6:e25952. 2011
    Angiotensin I-converting enzyme (ACE) metabolizes a range of peptidic substrates and plays a key role in blood pressure regulation and vascular remodeling...
  26. pmc The higher exercise intensity and the presence of allele I of ACE gene elicit a higher post-exercise blood pressure reduction and nitric oxide release in elderly women: an experimental study
    Hugo A P Santana
    Programa de Pós graduação em Educação Física e Saúde, Universidade Católica de Brasília UCB, Brasilia DF, Brazil
    BMC Cardiovasc Disord 11:71. 2011
    The absence of the I allele of the angiotensin converting enzyme (ACE) gene has been associated with higher levels of circulating ACE, lower nitric oxide (NO) release and hypertension...
  27. ncbi The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors
    L Wei
    Institut de la Santé et de la Recherche Médicale Unité 36, Paris, France
    J Biol Chem 267:13398-405. 1992
    The endothelial angiotensin I-converting enzyme (ACE; EC 3.4.15.1) has recently been shown to contain two large homologous domains (called here the N and C domains), each being a zinc-dependent dipeptidyl carboxypeptidase...
  28. ncbi ACE I/D gene polymorphism in primary FSGS and steroid-sensitive nephrotic syndrome
    Faruk Oktem
    Department of Pediatric Nephrology, School of Medicine, Suleyman Demirel University, Isparta, Turkey
    Pediatr Nephrol 19:384-9. 2004
    The role of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism in various renal disorders has been investigated...
  29. ncbi The angiotensin I-converting enzyme gene insertion/deletion polymorphism is linked to early gastric cancer
    Matthias P A Ebert
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Cancer Epidemiol Biomarkers Prev 14:2987-9. 2005
    The insertion/deletion polymorphism of the angiotensin I-converting enzyme (ACE) gene has recently been linked to the pathogenesis and progression of human cancers...
  30. ncbi The ACE gene polymorphism is associated with the incidence of gastric cancer among H. pylori seropositive subjects with atrophic gastritis
    Yasuyuki Goto
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Asian Pac J Cancer Prev 6:464-7. 2005
    Studies of the angiotensin converting enzyme (ACE) I/D polymorphism have provided evidence that the D/D genotype is associated with gastric tumor progression and numbers of lymph node metastases, but not with the overall risk of gastric ..
  31. ncbi Association of angiotensin I-converting enzyme gene insertion/deletion polymorphism and IgA nephropathy: a meta-analysis
    Du Yong
    Department of Nephrology, 2nd Affiliated Hospital, School of Medicine, Zhe Jiang University, Hangzhou, PR China
    Am J Nephrol 26:511-8. 2006
    The angiotensin I-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism has been extensively examined for the association with immunoglobulin A (IgA) nephropathy (IgAN), however, conflicting results have occurred...
  32. ncbi Angiotensin converting enzyme gene polymorphisms do not predict the course of idiopathic nephrotic syndrome in Swiss children
    Bernd Sasse
    Institute for Clinical Pathology, Department of Pathology, University Hospital, Zurich, Switzerland
    Nephrology (Carlton) 11:538-41. 2006
    Contradictory reports exist about a correlation of angiotensin I converting enzyme (ACE) gene polymorphisms to the outcome of idiopathic nephrotic syndrome (INS) in children...
  33. ncbi ACE gene polymorphism in Egyptian children with idiopathic nephrotic syndrome
    M E Fahmy
    Pediatric Department, Research Institute of Ophthalmology, Cairo, Egypt
    Bratisl Lek Listy 109:298-301. 2008
    Idiopathic nephrotic syndrome is a common renal disease in children. ACE gene insertion/deletion (I/D) polymorphism has been studied as a predictor of clinical response to steroid therapy.
  34. doi Association between renin-angiotensin system gene polymorphism and essential hypertension: a community-based study
    X Jiang
    Department of Geriatrics, First Affiliated Hospital, Nanjing Medical University, Nanjing, China
    J Hum Hypertens 23:176-81. 2009
    ..We examined six polymorphisms in the main component genes of RAS: angiotensin-converting enzyme (ACE) (I/D), angiotensinogen (AGT) (A-6G, A-20C, G-217A and T174 M) and angiotensin type 1 receptor (AT1R) (A1166C)...
  35. doi Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women
    Silvana Aparecida Alves Correa
    Molecular Gynaecology Laboratory, Department of Gynaecology, Federal University of Sao Paulo, Rua Pedro de Toledo, 781 4th Floor, Sao Paulo, 04039 032 SP, Brazil
    J Renin Angiotensin Aldosterone Syst 10:51-8. 2009
    ..of the renin-angiotensin system and the development of breast cancer in a case-control study by means of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) and angiotensin II type 1 (AT( 1))-receptor A1166C polymorphisms.
  36. doi Effect of angiotensin-converting enzyme gene insertion/deletion polymorphism on steroid resistance in Egyptian children with idiopathic nephrotic syndrome
    Maha Saber-Ayad
    Department of Pharmacology, Faculty of Medicine, Cairo University, Giza, Egypt
    J Renin Angiotensin Aldosterone Syst 11:111-8. 2010
    The presence of the deletion (D) allele in the angiotensin-converting enzyme (ACE) gene has been reported as a probable genetic risk factor for idiopathic nephrotic syndrome (INS), but its role in determining resistance to steroid ..
  37. doi The I/D polymorphism of angiotensin-converting enzyme gene and asthma risk: a meta-analysis
    Y G Zhang
    Department of Respiratory Medicine, West China Hospital of Sichuan University, Guoxuexiang 37, Chengdu, Sichuan, China
    Allergy 66:197-205. 2011
    The insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) gene has been implicated in susceptibility to asthma, but a large number of studies have reported inconclusive results...
  38. ncbi The hemoregulatory peptide N-acetyl-Ser-Asp-Lys-Pro is a natural and specific substrate of the N-terminal active site of human angiotensin-converting enzyme
    A Rousseau
    Centre National de la Recherche Scientifique, Institut de Chimie des Substances Naturelles, Gif Yvette, France
    J Biol Chem 270:3656-61. 1995
    Angiotensin I-converting enzyme (ACE) is a zinc-dipeptidyl carboxypeptidase, which contains two similar domains, each possessing a functional active site...
  39. pmc Shedding of somatic angiotensin-converting enzyme (ACE) is inefficient compared with testis ACE despite cleavage at identical stalk sites
    Z L Woodman
    Department of Medical Biochemistry, University of Cape Town, Rondebosch 7700, South Africa
    Biochem J 347:711-8. 2000
    The somatic and testis isoforms of angiotensin-converting enzyme (ACE) are both C-terminally anchored ectoproteins that are shed by an unidentified secretase...
  40. ncbi Genetic variation in the renin-angiotensin system and abdominal adiposity in men: the Olivetti Prospective Heart Study
    Pasquale Strazzullo
    Department of Clinical and Experimental Medicine, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    Ann Intern Med 138:17-23. 2003
    ..The renin-angiotensin system is involved in adipocyte growth and differentiation and possibly in adipose tissue metabolism...
  41. ncbi Association of gene polymorphism with genetic susceptibility to stroke in Asian populations: a meta-analysis
    Indranil Banerjee
    Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India
    J Hum Genet 52:205-19. 2007
    ..methylenetetrahydrofolate reductase (MTHFR), apolipoprotein E (ApoE) and angiotensin-converting enzyme (ACE)...
  42. ncbi Polymorphisms in the ACE and PAI-1 genes are associated with recurrent spontaneous miscarriages
    T Buchholz
    Department of Obstetrics and Gynecology, Grosshadern Hospital, Ludwig Maximilians University, 81377 Munich, Germany
    Hum Reprod 18:2473-7. 2003
    ..Fibrinolysis is tightly regulated by plasminogen activator inhibitor-1 (PAI-1). Endothelial PAI-1 synthesis is induced by angiotensin II, which is generated by angiotensin I-converting enzyme (ACE).
  43. ncbi The ACE gene insertion/deletion polymorphism and elite endurance swimming
    Georgios Tsianos
    Department of Biomedical and Life Sciences, University of Glasgow, 315 West Medical Building, G12 8QQ, Glasgow, Scotland
    Eur J Appl Physiol 92:360-2. 2004
    ..A variation in the human angiotensin I-converting enzyme (ACE) gene has been identified, in which the insertion (I) variant may be associated with elite endurance performance, ..
  44. pmc ACE2 gene expression is up-regulated in the human failing heart
    Andrew B Goulter
    Pharmagene Laboratories, 2 Orchard Road, Royston, Hertfordshire, UK, SG8 5HD
    BMC Med 2:19. 2004
    ACE2 is a novel homologue of angiotensin converting enzyme (ACE). ACE2 is highly expressed in human heart and animal data suggest that ACE2 is an essential regulator of cardiac function in vivo...
  45. doi Heterogeneous distribution of angiotensin I-converting enzyme (CD143) in the human and rat vascular systems: vessel, organ and species specificity
    Roman Metzger
    Department of Pediatric Surgery, University of Leipzig, Leipzig, Germany
    Microvasc Res 81:206-15. 2011
    Angiotensin I-converting enzyme (kininase II, ACE, CD143) availability is a determinant of local angiotensin and kinin concentrations and physiological actions...
  46. ncbi Increased shedding of angiotensin-converting enzyme by a mutation identified in the stalk region
    M Eyries
    Institut National de la Santé et de la Recherche Médicale Unit 525, Faculté de Médecine Pitié Salpêtrière, 91 Boulevard de l Hopital, 75013 Paris, France
    J Biol Chem 276:5525-32. 2001
    Angiotensin-converting enzyme (ACE), an enzyme that plays a major role in vasoactive peptide metabolism, is a type 1 ectoprotein, which is released from the plasma membrane by a proteolytic cleavage occurring in the stalk sequence ..
  47. ncbi Renin-angiotensin system gene polymorphisms: relationship with blood pressure and microalbuminuria in telmisartan-treated hypertensive patients
    J Redon
    Hypertension Clinic, Hospital Clinico, University of Valencia, Spain
    Pharmacogenomics J 5:14-20. 2005
    ..The results indicate that these RAS gene polymorphisms do not affect the antihypertensive activity and renoprotection in mild-to-moderate hypertensive patients treated with telmisartan...
  48. ncbi Pharmacogenetic association of the angiotensin-converting enzyme insertion/deletion polymorphism on blood pressure and cardiovascular risk in relation to antihypertensive treatment: the Genetics of Hypertension-Associated Treatment (GenHAT) study
    Donna K Arnett
    University of Minnesota, Division of Epidemiology, Minneapolis, USA
    Circulation 111:3374-83. 2005
    ..by genetic variation in the renin-angiotensin-aldosterone system, but no clinical trails have tested whether the ACE insertion/deletion (I/D) polymorphism modifies the association between the type of medication and multiple ..
  49. ncbi Influences of chymase and angiotensin I-converting enzyme gene polymorphisms on gastric cancer risks in Japan
    Mitsushige Sugimoto
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka, 431 3192, Japan
    Cancer Epidemiol Biomarkers Prev 15:1929-34. 2006
    ..Angiotensin II, which is generated by chymase and angiotensin I-converting enzyme (ACE), controls blood pressure as well as angiogenesis and cell proliferation...
  50. pmc Epistatic effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Genomics 89:362-9. 2007
    ..002) and between ACE and bradykinin B2 (p=0.003) polymorphisms on t-PA levels in females...
  51. pmc The gene polymorphism of the angiotensin I-converting enzyme correlates with tumor size and patient survival in colorectal cancer patients
    Christoph Rocken
    Institute of Pathology, Charite University Hospital, Berlin, Germany
    Neoplasia 9:716-22. 2007
    We studied the putative significance of angiotensin I-converting enzyme (ACE) in colorectal cancer (CRC) biology...
  52. doi Endothelial nitric oxide synthase, angiotensin-converting enzyme and angiotensinogen gene polymorphisms in hypertensive disorders of pregnancy
    Pardeep Kumar Aggarwal
    Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Hypertens Res 33:473-7. 2010
    ..the variations in genes encoding endothelial nitric oxide synthase (NOS3), angiotensin-converting enzyme (ACE) and angiotensinogen (AGT) in hypertensive disorders of pregnancy and the relationship between the polymorphisms ..
  53. ncbi RAS genes influence exercise-induced left ventricular hypertrophy: an elite athletes study
    C Fatini
    Unità di Genetica Medica Dpt Fisiopatol Clinica, Centro Medicina dello Sport, Universita di Firenze, Florence, Italy
    Med Sci Sports Exerc 32:1868-72. 2000
    The association of ACE I/D polymorphism with changes in LV mass in response to physical training has been observed, but no association has been found with AT1R A1166C polymorphism...
  54. ncbi Levels of plasma angiotensin-(1-7) in patients with hypertension who have the angiotensin-I-converting enzyme deletion/deletion genotype
    Jorge E Jalil
    Department of Cardiovascular Diseases, Medical School, Pontifica Catholic University of Chile, Marcoleta 367, Room 19, Santiago, Chile
    Am J Cardiol 92:749-51. 2003
    In patients with hypertension who have the DD-ACE genotype (higher angiotensin-converting enzyme [ACE] activity), plasma levels of angiotensin-(1-7) are 4 times lower than in patients with the II-ACE genotype (lower ACE levels)...
  55. ncbi Insertion/deletion polymorphism of angiotensin I converting enzyme gene and left ventricular hypertrophy in patients with type 2 diabetes mellitus
    Piotr Moleda
    Klinika Endokrynologii, Nadciśnienia Tetniczego i Chorób Przemiany Materii PAM, ul Arkonska 4, 71 455 Szczecin, Poland
    Kardiol Pol 64:959-65; discussion 966. 2006
    ..Since the I/D polymorphism of angiotensin-converting enzyme (ACE) gene influences the activity of RAA, it is likely that it could also have an impact on LVH.
  56. ncbi Effect of angiotensin converting enzyme inhibitors on 1.25-(OH)2 D levels of hypertensive patients. Relationship with ACE polymorphisms
    J L Perez-Castrillon
    Departamento de Medicina Interna, Hospital Universitario Rio Hortega, Facultad de Medicina de Valladolid, Valladolid, Spain
    Horm Metab Res 38:812-6. 2006
    The effect of angiotensin converting enzyme inhibitors (ACEIs) on 1.25-dihydroxyvitamin D [1.25-(OH)2D] levels has not been studied. The purpose of this study is to assess the relationship between 1...
  57. ncbi Angiotensin-converting enzyme gene 2350 G/A polymorphism is associated with left ventricular hypertrophy but not essential hypertension
    Min Pan
    Department of Cardiology, Affiliated Hospital of Nantong University, P R China
    Hypertens Res 30:31-7. 2007
    The angiotensin-converting enzyme (ACE) gene (ACE) is one of the most studied candidate genes related to essential hypertension (EH) and left ventricular hypertrophy (LVH)...
  58. doi The D allele of angiotensin I-converting enzyme gene insertion/deletion polymorphism is associated with the severity of atherosclerosis
    Pawel Niemiec
    Department of Biochemistry and Medical Genetics, Medical University of Silesia, Katowice, Poland
    Clin Chem Lab Med 46:446-52. 2008
    Angiotensin II is produced primarily by angiotensin I-converting enzyme (ACE) within atherosclerotic lesions and ACE level in plaques correlates with the severity of vessel wall damage...
  59. doi The angiotensin converting enzyme gene I/D polymorphism in Polish rowers
    P Cieszczyk
    Institute of Physical Culture, University of Szczecin, Szczecin, Poland
    Int J Sports Med 30:624-7. 2009
    b>Angiotensin converting enzyme gene (ACE) is the most frequent investigated gene in the context of genetic conditioning of sports-predispositions...
  60. doi Association between the angiotensin I-converting enzyme gene insertion/deletion polymorphism and endurance running speed in Japanese runners
    Takuro Tobina
    Graduate School of Sports and Health Science, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka, 810 0180, Japan
    J Physiol Sci 60:325-30. 2010
    We investigated the association between the angiotensin I-converting enzyme (ACE) gene insertion (I)/deletion (D) polymorphism and endurance running performance in Japanese elite runners, including several Olympic athletes...
  61. doi Increased risk of myocardial infarction associated with angiotensin-converting enzyme gene polymorphism is age dependent
    Bettina A Hamelin
    Quebec Heart Institute, Quebec, Canada
    J Clin Pharmacol 51:1286-92. 2011
    The angiotensin-converting enzyme (ACE) gene is a candidate genetic locus for coronary artery disease (CAD)...
  62. pmc ACE gene insertion/deletion polymorphism has a mild influence on the acute development of left ventricular dysfunction in patients with ST elevation myocardial infarction treated with primary PCI
    Jiri Parenica
    Cardiology Department, Faculty Hospital Brno, Jihlavska 20, Brno 625 00, Czech Republic
    BMC Cardiovasc Disord 10:60. 2010
    We evaluated the associations among angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism, ACE activity and post-myocardial infarction (MI) left ventricular dysfunction and acute heart failure (AHF) early after ..
  63. doi Association between ACE polymorphism and risk of IgA nephropathy: a meta-analysis
    Yuan Han Qin
    Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, China
    J Renin Angiotensin Aldosterone Syst 12:215-23. 2011
    and objective: The effect of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism on risk or progression of immunoglobulin A nephropathy (IgAN) is still debated...
  64. doi Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with high-altitude pulmonary oedema: a meta-analysis
    Yue Qi
    Department of Epidemiology, Capital Medical University Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China
    J Renin Angiotensin Aldosterone Syst 12:617-23. 2011
    ..We aimed to assess the association between the angiotensin-converting enzyme (ACE) I/D polymorphism and HAPE via a meta-analysis of published and unpublished data.
  65. doi The association between angiotensin-converting enzyme insertion/deletion gene variant and risk of focal segmental glomerulosclerosis: a systematic review and meta-analysis
    Tian Biao Zhou
    Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
    J Renin Angiotensin Aldosterone Syst 12:624-33. 2011
    The association of the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism with the risk of focal segmental glomerulosclerosis (FSGS) is still controversial...
  66. pmc Lack of association between gene polymorphisms of Angiotensin converting enzyme, Nod-like receptor 1, Toll-like receptor 4, FAS/FASL and the presence of Helicobacter pylori-induced premalignant gastric lesions and gastric cancer in Caucasians
    Juozas Kupcinskas
    Department of Gastroenterology, Lithuanian University of Health Sciences, Eiveniu 2, 50009 Kaunas, Lithuania
    BMC Med Genet 12:112. 2011
    ..between the presence of gastric cancer (GC) and high risk atrophic gastritis (HRAG) and polymorphisms of genes encoding Angiotensin converting enzyme (ACE), Nod-like receptor 1 (NOD1), Toll-like receptor 4 (TLR4) and FAS/FASL.
  67. ncbi The role of ACE gene polymorphism on pathogenesis of ischemic stroke
    Taufik Indrajaya
    Department of Internal Medicine, Faculty of Medicine, Sriwijaya University Mohammad Hoesin Hospital, Indonesia
    Acta Med Indones 43:152-7. 2011
    to describe the role of ACE gene polymorphism on pathogenesis of ischemic stroke in patients with the history of hypertension. The study was conducted in a population of Palembang city.
  68. ncbi ACE gene polymorphism and IgA nephropathy: an ethnically homogeneous study and a meta-analysis
    F P Schena
    Division of Nephrology, Department of Emergency and Organ Transplantation, University of Bari, Policlinic, Bari, Italy
    Kidney Int 60:732-40. 2001
    Conflicting results have implicated the angiotensin-converting enzyme (ACE) D allele in the progression of renal damage in patients with IgA nephropathy (IgAN). Most of these findings have been obtained by heterogeneous studies.
  69. ncbi Enhanced responses of blood pressure, renal function, and aldosterone to angiotensin I in the DD genotype are blunted by low sodium intake
    Frank G H van der Kleij
    Groningen University Institute for Drug Exploration, University Hospital, Hanzeplein 1, P O Box 30 001, 9700 RB Groningen, The Netherlands
    J Am Soc Nephrol 13:1025-33. 2002
    Angiotensin-converting enzyme (ACE) activity is increased in the DD genotype, but the functional significance for renal function is unknown...
  70. ncbi Hypertension after renal transplantation and polymorphism of genes involved in essential hypertension: ACE, AGT, AT1 R and ecNOS
    El Essawy A Basset
    Nephrology, Dialysis and Renal Transplantation Department, Hĵpital Nord, CHU de Saint Etienne, France
    Clin Nephrol 57:192-200. 2002
    ....
  71. ncbi Haplotypes extending across ACE are associated with Alzheimer's disease
    Patrick G Kehoe
    Department of Care of the Elderly, University of Bristol, The John James Building, Frenchay Hospital, Bristol, UK
    Hum Mol Genet 12:859-67. 2003
    ..One of the most widely studied is the gene for angiotensin I converting enzyme (ACE )...
  72. ncbi Interaction between the polymorphisms of the renin-angiotensin system in preeclampsia
    Ioanna Bouba
    Genetics Unit, Department of Obstetrics and Gynecology, Medical School, University of Ioannina, 45500, Ioannina, Greece
    Eur J Obstet Gynecol Reprod Biol 110:8-11. 2003
    ..angiotensinogen gene (AGT), the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme gene (ACE) and the A1166C polymorphism of the angiotensin II type 1 receptor gene (AT1R) by PCR...
  73. pmc Association of Angiotensin-converting enzyme and angiotensinogen gene polymorphisms with preeclampsia
    Hyunah Choi
    Department of Medicine Cardiology, Samsung Cheil Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 19:253-7. 2004
    We tested the hypothesis that angiotensin-converting enzyme (ACE) and angiotensinogen gene polymorphism influence the incidence, development and outcome of preeclampsia...
  74. ncbi Hypertension-related gene polymorphisms in pre-eclampsia, eclampsia and gestational hypertension in Black South African women
    Candice B Roberts
    Departments of Obstetrics and Gynaecology, MRC UN Pregnancy Hypertension Research Unit, Nelson R Mandela School of Medicine, University of Natal, Private Bag 7, Congella, 4013 Durban, South Africa
    J Hypertens 22:945-8. 2004
    ..To examine whether polymorphisms in the renin-angiotensin system (RAS) are associated with pregnancy-related hypertensive disorders in a black South African population...
  75. ncbi Insertion/deletion polymorphism of the angiotensin-converting enzyme gene and preeclampsia in Japanese patients
    Gen Kobashi
    Division of Preventive Medicine, Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Sapporo, Japan
    Semin Thromb Hemost 31:346-50. 2005
    To clarify whether the homozygous deletion (DD) genotype of angiotensin-converting enzyme gene ( ACE) is a genetic risk factor for preeclampsia in Japanese women, we performed ACE genotyping in patients with preeclampsia and healthy ..
  76. ncbi ACE gene polymorphism in Turkish children with nephrotic syndrome
    Umit Sizmaz Celik
    Department of Pediatric Nephrology, Cukurova University, School of Medicine, Adana, Turkey
    Ren Fail 28:401-3. 2006
    Since 1990, the role of angiotensin converting enzyme (ACE) gene polymorphism in various renal and cardiac diseases is still debated...
  77. ncbi Synergistic expression of angiotensin-converting enzyme (ACE) and ACE2 in human renal tissue and confounding effects of hypertension on the ACE to ACE2 ratio
    Shigeyuki Wakahara
    Third Department of Internal Medicine, Fukui University School of Medicine, 23 3, Shimoaizuki, Eiheiji, Fukui, 910 1193, Japan
    Endocrinology 148:2453-7. 2007
    Angiotensin-converting enzyme (ACE) 2, a newly emerging component of the renin-angiotensin system, is presumed to be a counterregulator against ACE in generating and degrading angiotensin II...
  78. ncbi Reduced plasma levels of angiotensin-(1-7) and renin activity in preeclamptic patients are associated with the angiotensin I- converting enzyme deletion/deletion genotype
    E P Velloso
    Departamento de Fsiologia corrected Universidade Federal de Minas Gerais, Belo Horizonte, MG corrected Brasil
    Braz J Med Biol Res 40:583-90. 2007
    ..Angiotensin I-converting enzyme (ACE) is a key RAS component and plays an important role in blood pressure homeostasis by generating angiotensin II (Ang ..
  79. ncbi Association of ACE genotype and predominantly diastolic hypertension: a preliminary study
    Pablo Martin Jiménez
    Institute for Medical Research Mercedes y Martín Ferreyra INIMEC CONICET, Cordoba, Argentina
    J Renin Angiotensin Aldosterone Syst 8:42-4. 2007
    The insertion/deletion (I/D) angiotensin-converting enzyme (ACE) polymorphism has been established as a cardiovascular risk factor in some populations, but the association with essential hypertension is controversial...
  80. ncbi Synergistic effect of renin-angiotensin system and nitric oxide synthase genes polymorphisms in pre-eclampsia
    Chiara Benedetto
    Department of Obstetrics and Gynecology, University of Torino, Torino, Italy
    Acta Obstet Gynecol Scand 86:678-82. 2007
    ..The aim of this study was to assess if interactions among different polymorphisms of the renin-angiotensin system and nitric oxide synthase are involved in the pathogenesis of pre-eclampsia...
  81. ncbi Angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensin II type 1 receptor (AT1R) gene polymorphism and its association with preeclampsia in Chinese women
    Hua Li
    Qilu Hospital, Shandong University, Jinan, China
    Hypertens Pregnancy 26:293-301. 2007
    To investigate whether polymorphisms of angiotensin converting enzyme gene (ACE) and angiotensin II receptor type 1 gene (AT1R) are associated with etiology of preeclampsia and renal impact in women with preeclampsia.
  82. ncbi Association of angiotensin-converting enzyme insertion-deletion polymorphism with preeclampsia
    Berivoj Miskovic
    Department of Obstetrics and Gynecology, School of Medicine, University of Zagreb, General Hospital Sveti Duh, Zagreb, Croatia
    Coll Antropol 32:339-43. 2008
    ..The deletion genotype could be an important contributing factor for an early onset and recurrent preeclampsia...
  83. doi Association between ACE D allele and elite short distance swimming
    Aldo Matos Costa
    Department of Sports Science, University of Beira Interior, Rua Marques d Avila e Bolama, 6201 001, Covilha, Portugal
    Eur J Appl Physiol 106:785-90. 2009
    The influence of ACE gene on athletic performance has been widely explored, and most of the published data refers to an I/D polymorphism leading to the presence (I allele) or absence (D allele) of a 287-bp sequence in intron 16, ..
  84. doi Angiotensin-converting enzyme gene insertion/deletion polymorphism in Egyptian patients with myocardial infarction
    Ahmad Settin
    Department of Genetics, Faculty of Medicine, Mansoura University, Mansoura, Egypt
    J Renin Angiotensin Aldosterone Syst 10:96-100. 2009
    ..This work aimed to test the association of the angiotensin-converting enzyme gene insertion/deletion (I/D) polymorphism with myocardial infarction...
  85. doi Association of angiotensin-converting enzyme intron 16 insertion/deletion polymorphism with history of foetal loss
    Larisa Bukreeva
    Institute of Transfusion Medicine, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    J Renin Angiotensin Aldosterone Syst 10:237-40. 2009
    The angiotensin-converting enzyme (ACE) intron 16 insertion/deletion (I/D) polymorphism is associated with ACE activity and has been discussed as a risk factor for pre-eclampsia...
  86. doi Are polymorphisms in the ACE and PAI-1 genes associated with recurrent spontaneous miscarriages?
    Chelsi Goodman
    CARI Reproductive Institute, Chicago, IL, USA
    Am J Reprod Immunol 62:365-70. 2009
    To determine whether the ACE D/D genotype or the combination of PAI-1 4G/4G and ACE D/D genotypes may serve as a risk factor for recurrent pregnancy loss.
  87. doi Angiotensin converting enzyme DD genotype not associated with increased risk of coronary artery disease in the Iranian population
    Sayed Mohammad Shafiee
    Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
    Pathophysiology 17:163-7. 2010
    ..CAD) is of the main causes of heart failure and there is evidence supporting the association of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and the susceptibility to CAD...
  88. ncbi Lack of association between renin-angiotensin system (RAS) polymorphisms and hypertension in Tunisian type 2 diabetics
    Imen Arfa
    Molecular Investigation of Genetic Orphan Diseases Research Unit, Institut Pasteur de Tunis, Tunisia
    Tunis Med 88:38-41. 2010
    ..RAS) components are potent candidate genes in both hypertension and diabetes namely ACE encoding the angiotensin converting enzyme and AGT encoding angiotensinogen...
  89. pmc Angiotensin I-converting enzyme Gln1069Arg mutation impairs trafficking to the cell surface resulting in selective denaturation of the C-domain
    Sergei M Danilov
    Department of Anesthesiology, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 5:e10438. 2010
    Angiotensin-converting enzyme (ACE; Kininase II; CD143) hydrolyzes small peptides such as angiotensin I, bradykinin, substance P, LH-RH and several others and thus plays a key role in blood pressure regulation and vascular remodeling...
  90. doi Insertion/Deletion polymorphism of Angiotensin-converting enzyme as a risk factor for chronic allograft nephropathy
    R Fedor
    Department of Surgery, Transplantation Center, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    Transplant Proc 42:2304-8. 2010
    Angiotensin-converting enzyme (ACE) inhibitor therapy is widely used to treat chronic allograft nephropathy (CAN), which suggests a possible role of the renin-angiotensin system in the pathologic mechanism of the disease...
  91. ncbi Genetic polymorphisms of the renin-angiotensin-aldosterone system in Chinese patients with end-stage renal disease secondary to IgA nephropathy
    Hai Dong Huang
    Department of Nephrology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
    Chin Med J (Engl) 123:3238-42. 2010
    ..The angiotensin I-converting enzyme (ACE) gene insertion/deletion (I/D), the angiotensinogen (AGT) gene, M235T, the aldosterone synthase (CYP11B2) gene, C-..
  92. ncbi Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design
    Hazel R Corradi
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    J Mol Biol 357:964-74. 2006
    ..Previously we determined the structure of testis ACE (C domain); here we present the crystal structure of the N domain of sACE (both in the presence and absence of the ..
  93. ncbi The D-allele of the ACE polymorphism is related to increased QT dispersion in 609 patients after myocardial infarction
    A Jeron
    Innere Medizin II, Klinikum der Universitat Regensburg, Regensburg, Germany
    Eur Heart J 22:663-8. 2001
    ..Angiotensin-converting enzyme (ACE) inhibition has been shown to reduce QT dispersion in myocardial infarction patients...
  94. ncbi A meta-analysis of the angiotensin-converting enzyme gene polymorphism and restenosis after percutaneous transluminal coronary revascularization: evidence for publication bias
    Willem R P Agema
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am Heart J 144:760-8. 2002
    ..Genetic association studies addressing this issue are frequently hampered by insufficient power. Therefore, we conducted a meta-analysis of this association, taking into account the possibility of publication bias...
  95. ncbi Purification and characterization of recombinant human testis angiotensin-converting enzyme expressed in Chinese hamster ovary cells
    M R Ehlers
    Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, Boston, Massachusetts 02115
    Protein Expr Purif 2:1-9. 1991
    Enzymatically active human testis angiotensin-converting enzyme (ACE) was expressed in Chinese hamster ovary (CHO) cells stably transfected with each of three vectors: p omega-ACE contains a full-length testis ACE cDNA under the control ..
  96. ncbi The insertion/deletion polymorphism of the angiotensin-converting enzyme gene determines coronary vascular tone and nitric oxide activity
    A Prasad
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1650, USA
    J Am Coll Cardiol 36:1579-86. 2000
    We investigated whether the insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene modulates vasomotor tone and endothelial function.
  97. ncbi Determination of human angiotensin converting enzyme (ACE) gene polymorphisms in erectile dysfunction: frequency differences of ACE gene polymorphisms according to the method of analysis
    D S Kim
    Department of Clinical Pathology, Chonbuk National University Medical School, South Korea
    Clin Chem Lab Med 39:11-4. 2001
    The D polymorphism of angiotensin converting enzyme (ACE) gene has been found to be associated with various diseases, and ACE may also be involved in the pathogenesis of erectile dysfunction...
  98. ncbi Association of angiotensinogen M235T and A(-6)G gene polymorphisms with coronary heart disease with independence of essential hypertension: the PROCAGENE study. Prospective Cardiac Gene
    J C Rodriguez-Perez
    Research Unit, Hemodynamic Cardiology and Nephrology Services, Hospital de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Canary Islands, Spain
    J Am Coll Cardiol 37:1536-42. 2001
    ..AGT) gene M235T polymorphism, the variant promoter of the AGT gene A(-6)G and the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and coronary heart disease (CHD) in native Gran Canaria Island ..
  99. ncbi Angiotensin converting enzyme gene insertion/deletion polymorphism in idiopathic nephrotic syndrome in Kuwaiti Arab children
    A Al-Eisa
    Paediatrics Department, Faculty of Medicine, Kuwait University, Kuwait
    Scand J Urol Nephrol 35:239-42. 2001
    b>Angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism influence the circulating and cellular levels of ACE and has been shown to be a risk factor in a number of diseases including IgA nephropathy...
  100. ncbi The insertion/deletion polymorphism of the ACE gene is related to insulin sensitivity in overweight women
    A S Ryan
    Department of Medicine, Division of Gerontology at the University of Maryland School of Medicine, Baltimore, MD, USA
    Diabetes Care 24:1646-52. 2001
    The ACE insertion/deletion (I/D) polymorphism has been identified as a genetic risk factor for coronary heart disease (CHD). The deletion (D) allele of the ACE gene may be associated with higher insulin sensitivity...
  101. ncbi ACE and angiotensinogen gene genotypes and left ventricular mass in athletes
    F Diet
    Klinik fur Innere Medizin III, Universitat zu Koln, Joseph Stelzmann Strasse 9, 50924 Köln, Germany
    Eur J Clin Invest 31:836-42. 2001
    ..The significance of polymorphisms of genes of the renin-angiotensin system in myocardial mass in a population of athletes participating in different disciplines is not known...

Research Grants73

  1. JAMES MATTHEW LUTHER; Fiscal Year: 2016
    ..Angiotensin I converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs) reduce blood pressure and cardiovascular mortality...
  2. Role of the Renin-Angiotensin system in placental insufficiency
    Eugenia Mata-Greenwood; Fiscal Year: 2013
    ..and maternal RAS dysregulation, characterized by higher Angiotensin II, Angiotensin I-converting enzyme (ACE) and Angiotensin II receptor 1 (AGTR1) expression...
  3. 2010 Angiotensin Gordon Research Conference
    Kathy K Griendling; Fiscal Year: 2010
    ..the development and latest application of angiotensin-based therapies - from the serendipitous identification of ACE inhibitors in snake venom, through AT1 receptor blockers, renin inhibitors, AT2 receptor agonists, recombinant ACE2 ..
  4. Vitamin D Deficiency Augments Renin-Angiotensin System Activity in Obesity
    Anand Vaidya; Fiscal Year: 2011
    ..Aim 1) and RBF (Aim 2) response to AngII, consistent with diminished endogenous RAS activity akin to the effect of ACE inhibitors (Aim 3)...
  5. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  6. ACE and ACE2 in Glomerular Angiotensin Peptides Metabolism
    JAN ANDRZEJ WYSOCKI; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Angiotensin I converting enzyme (ACE) forms the hormone, angiotensin (ANG) II. The surplus of ANG II has been implicated in the development of diabetic kidney disease...
  7. NAHID JAMAL RIANON; Fiscal Year: 2014
    ..Antihypertensive medications affecting RAS, specifically angiotensin converting enzyme inhibitors (ACEI), decreased bone turnover in animals, and improved BMD in preliminary human studies...
  8. Genome-wide case-only study of antihypertensive drug-gene interactions
    Bruce M Psaty; Fiscal Year: 2010
    ..genomic regions for each of the 4 major drug classes (600 for all 4 drug groups [diuretics, beta-blockers, ACE inhibitors, calcium antagonists])...
  9. Pravin C Singhal; Fiscal Year: 2014
    ..lesions in non-HIVAN models of FGS, we hypothesize that use of these agents either alone or in combination with ACE (angiotensin I converting enzyme) inhibitors/AT1 receptor blockers will not only attenuate or prevent HIV-1-induced ..
  10. STATINS AND ACE INHIBITORS IN ADULTS WITH DIABETES AND COMORBID CONDITIONS
    David E Grembowski; Fiscal Year: 2010
    ..with diabetes are for cardiovascular disease, and reducing macrovascular disease progression through statin and ACE (angiotensin-converting enzyme) inhibitor treatments is an important element of diabetes care. Aims...
  11. Nocturnal Hypertension and Prevention of Microalbuminuria in Type I Diabetics
    MARK ELLIS MOLITCH; Fiscal Year: 2010
    ..Yet, early pharmacological intervention with ACE inhibitors is currently recommended only after there is an indication of kidney damage, as reflected by the ..
  12. Kenneth E Bernstein; Fiscal Year: 2015
    ..b>Angiotensin converting enzyme (ACE) plays an important role in blood pressure control, and ACE inhibitors are in widespread clinical ..
  13. Comparative Effectiveness of ACE Inhibitors for African Americans
    GBENGA GODWIN OGEDEGBE; Fiscal Year: 2011
    DESCRIPTION (provided by the PI): ACE inhibitors are a standard treatment for hypertensive patients...
  14. ANGIOTENSIN II SIGNAL TRANSDUCTION
    Bradford C Berk; Fiscal Year: 2012
    ..angiotensin system in cardiovascular disease has been proven by the positive clinical benefits associated with ACE inhibitors and angiotensin type 1 receptor (AT1R) blockers...
  15. Development of the orally delivered, non-absorbable ACE inhibitor enalaprilat for
    ELKE LIPKA; Fiscal Year: 2010
    ..sodium sulfate (DSS) model through blockage of signaling via the inhibition of the angiotensin-converting enzyme (ACE) in the renin-angiotensin system...
  16. The Renin-Angiotensin System, Inflammation and Radiation-induced Brain Injury
    Michael E Robbins; Fiscal Year: 2010
    ..3 and 4 we will test the hypothesis that inhibiting the intrinsic brain RAS using RAS blockers targeted at either ACE (ACEI), or the Ang II receptors (AT1RA and AT2RA) will ameliorate the development and progression of radiation-..
  17. Samuel C Dudley; Fiscal Year: 2014
    ..A critical component of this system is angiotensin converting enzyme (ACE), which cleaves the decapeptide angiotensin I, producing the eight amino acid peptide angiotensin ..
  18. Novel Aspects of the Cardiac Renin-Angiotensin System
    KENNETH MELVIN BAKER; Fiscal Year: 2012
    ..Intracellular Ang II (iAng II) synthesis in high glucose conditions is chymase, not angiotensin converting enzyme (ACE) dependent. Intracellular synthesis of Ang II is completely blocked by a renin inhibitor...
  19. Strategies for ACE2 Amplification to Treat Diabetic Kidney Disease
    Daniel Batlle; Fiscal Year: 2012
    ACE2 is a type 1 integral membrane protein that shares 42% homology with the metalloprotease catalytic domains of ACE. Whereas ACE promotes the formation of angiotensin II, ACE2 promotes the degradation of angiotensin (ANG) II to ..
  20. CHIH CHANG KEVIN WEI; Fiscal Year: 2014
    ..Currently, therapy with angiotensin-converting enzyme (ACE) inhibitors, which decreases angiotensin II and increases bradykinin (BK), is ineffective in a pathophysiologic LV ..
  21. Nancy J Brown; Fiscal Year: 2014
    ..Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers decrease incident diabetes in clinical trials in patients with ..
  22. Nancy J Brown; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Angiotensin-converting enzyme (ACE) inhibitors reduce mortality in hypertension, heart disease and diabetes...
  23. University of Iowa Older Adults CERT
    Elizabeth A Chrischilles; Fiscal Year: 2010
    ..Under-use of certain medications like beta blockers or ACE inhibitors is also of concern...
  24. FRANK IRVING SCOTT; Fiscal Year: 2016
    ..Finally, he will assess the effects of statins and ACE-inhibitors, which have known pleiotropic anti-fibrotic effects, on the incidence of post-operative SBO (AIM 3)...
  25. Research Centers in Minority Institutions Clinical Rese*
    Eve Higginbotham; Fiscal Year: 2009
    ..IV. Define the efficacy of chronic treatment with angiotensin converting enzyme inhibitors as a means to improve endothelial function in African-American hypertensives with baseline ..
  26. Vasopeptidases and Beta Amyloid Accumulation
    Christopher Eckman; Fiscal Year: 2009
    ..For example, angiotensin-converting enzyme (ACE) inhibitors are FDA approved and widely used to treat hypertension and heart failure...
  27. Jerry H Gurwitz; Fiscal Year: 2014
    ..lung disease dyad group;and (3) to assess the clinical effectiveness and safety associated with the use of ACE inhibitors/angiotensin II receptor blockers (ARBs) and aldosterone antagonists for patients in the HF-chronic ..
  28. Neural Predictors and RAS Modulation of Radiation-induced Cognitive Impairment
    Michael E Robbins; Fiscal Year: 2010
    ..clinically relevant course of WBI, and ii] determine if inhibition of the intrinsic brain RAS by administration of ACE inhibitors or Ang II type 1 receptor antagonists will modulate the structural and/or cognitive damage after 12 ..
  29. BRADYKININ VASCULAR INFLUENCE AND ACE INHIBITION
    BEN ZIMMERMAN; Fiscal Year: 1993
    ..its interaction with the renin-angiotensin system in the kidney and its contribution to the effect of angiotensin converting enzyme (ACE) inhibitors is not well understood...
  30. Is Tissue ACE Required for Diabetic Renal Damage?
    Harold Franch; Fiscal Year: 2005
    b>Angiotensin converting enzyme (ACE), a carboxyl-peptidase that converts the inactive precursor angiotensin linto the active angiotesion II, plays a crucial role in the development and progression of diabetic nephropathy...
  31. Balance of Angiotensin II/Angiotensin (1-1): A Target in Ischemic Stroke
    Yanfang Chen; Fiscal Year: 2013
    ..The angiotensin (Ang) converting enzyme (ACE), Ang II and Ang AT1 receptor of the renin-angiotensin system (RAS) participate in the pathophysiology of various ..
  32. Intrarenal Angiotensin II generation during Angiotensin II-induced hypertension
    ROMER ANDRES GONZALEZ-VILLALOBOS; Fiscal Year: 2013
    ..goals of this project are to establish the importance and underlying mechanisms mediating the effects of intrarenal ACE-derived Ang II generation on the development of hypertension and renal injury while facilitating the applicant[..
  33. Michal Laniado Schwartzman; Fiscal Year: 2015
    ..between the CYP4A-derived 20-HETE and the renin angiotensin system and investigate the role of endothelial ACE in 20-HETE-mediated vascular dysfunction and hypertension...
  34. Intrarenal Angiotensin II generation during Angiotensin II-induced hypertension
    ROMER ANDRES GONZALEZ VILLALOBOS; Fiscal Year: 2010
    ..Because is known that angiotensin-converting enzyme (ACE) is responsible for most of Ang I conversion to Ang II in the mouse kidney, this project will take advantage of ..
  35. Mechanisms of action of angiotensin-II on C1 neurons.
    Seth D DePuy; Fiscal Year: 2010
    ..Under pathological conditions, upregulation of the RAS, including AT1 receptors and angiotensin converting enzyme (ACE), produces a tonic activation of presympathetic neurons that can be abrogated by receptor ..
  36. Environmental & Genetic Risk Factors for Renal Function
    Virginia Weaver; Fiscal Year: 2009
    ..of lead or cadmium dose with renal function decline;and 4) whether polymorphisms in the genes for ALAD, VDR, ACE, and eNOS modify or continue to modify relations of lead and/or cadmium dose with renal outcomes...
  37. Non-Modulation Phenotype and Vascular Dysfunction in Diabetes Mellitus
    Gordon H Williams; Fiscal Year: 2010
    ..polymorphisms in diabetic and HBPive non-modulators;increased levels of inflammatory markers that correlate with RAAS activity;and correction of the abnormalities in the non-modulating but not other diabetics with ACE inhibition.
  38. New drug Vida-5 for treating chronic kidney disease progression
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2011
    ..Current treatments including ACE inhibitors for CKD patients mainly focus on managing symptoms and disease complications...
  39. Novel drug VS-105 for treatment of diabetic nephropathy
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2012
    ..Current treatments including ACE inhibitors for CKD patients mainly focus on managing symptoms and disease complications...
  40. Joseph Y Cheung; Fiscal Year: 2014
    ..In addition, the 2 classes of drugs (b-blockers and ACE inhibitors) that have been clinically found to be efficacious in congestive heart failure and ischemic heart ..
  41. Ahsan Husain; Fiscal Year: 2014
    ..We show that combined ACE + chymase inhibition improves left ventricle (LV) function, decreases adverse cardiac remodeling, and markedly ..
  42. Prevention of Diabetic Neuropathy with ACE Inhibitors
    MARK ANTHONY YOREK; Fiscal Year: 2012
    ..diabetes, or Zucker obese rats, an animal model for pre-diabetes/metabolic syndrome with Enalapril, an angiotensin converting enzyme (ACE) inhibitor, AVE7688, a vasopeptidase inhibitor, or Sitagliptin, a dipeptidyl peptidase IV (DPP-IV)..
  43. Anthony Martin Gerdes; Fiscal Year: 2015
    ..survival from myocardial infarction (MI) has improved with the use of 2-adrenergic blockers (BB) and angiotensin converting enzyme inhibitors (ACEi)...
  44. MEETHA M MEDHORA; Fiscal Year: 2016
    ..We have focused on a class of drugs, angiotensin converting enzyme (ACE) inhibitors, which have been used in the clinic for many indications...
  45. MOLECULAR ASPECTS OF ALPORT RENAL DISEASE PROGRESSION
    DOMINIC E COSGROVE; Fiscal Year: 2013
    ..Currently the 1 in 20,000 people with the disease are treated with ACE inhibitors, dialysis, and transplant...
  46. Role of Retinoid Mediated Signaling in Diabetes and Cardiac Remodeling
    KENNETH MELVIN BAKER; Fiscal Year: 2010
    ..Suppression of the RAS, using angiotensin converting enzyme (ACE) inhibitors (ACEI) and AT1R blockers (ARBS), has been shown to reduce cardiovascular events...
  47. ANA CATHERINE RICARDO; Fiscal Year: 2016
    ..g., ACE- inhibitors) or lifestyle interventions (e.g., exercise)...
  48. Longitudinal C-Reactive Protein Levels and Outcomes in Hemodialysis Patients
    JONATHAN WILLIAM BAZELEY; Fiscal Year: 2010
    ..following treatments lower CRP levels: medications including vitamin D analogues, angiotensin-converting enzyme (ACE ) inhibitors, angiotensin receptor blockers (ARBs), and aspirin;and dialysis treatments including longer treatment ..
  49. Management and Outcomes of Heart Failure with Preserved Systolic Function
    Alan S Go; Fiscal Year: 2010
    ..e., ACE inhibitors, beta-blockers, and aldosterone receptor antagonists) that have been proven to be beneficial for ..
  50. Development of ACE Inhibitor as Countermeasure for Radiation-Induced Lung Injury
    MEETHA M MEDHORA; Fiscal Year: 2010
    ..Specifically we propose to accelerate development of FDA-approved Angiotensin Converting Enzyme inhibitors (ACEi), captopril, enalapril or fosinopril for safe and effective mitigation and treatment...
  51. Gang Fang; Fiscal Year: 2014
    ..b>ACE inhibitors are one of the recommended preventive therapies after AMI...
  52. Impact of New Technologies on Chronic Heart Failure Outcomes and Costs in the VHA
    Peter W Groeneveld; Fiscal Year: 2013
    ..While some technologies such as ACE- inhibitors currently are used in almost all veterans with CHF, devices and beta-blockers are not yet used in all ..
  53. ACE Inhibition and Cardiac Allograft Vasculopathy
    William F Fearon; Fiscal Year: 2013
    ..b>Angiotensin converting enzyme inhibitors are used in less than one half of transplant recipients...
  54. Systems Biology of Anionic Drug and Metabolite Handling
    Sanjay K Nigam; Fiscal Year: 2012
    Many commonly prescribed anionic drugs (eg. antibiotics, diuretics, ACE inhibitors, NSAIDs) as well as disease-associated metabolites are organic anions that are excreted as a result of transport by the proximal tubule of the kidney...
  55. Rachel Gold; Fiscal Year: 2014
    ..Adults with DM and other risk factors who take aspirin, statins, and ACE Inhibitors can reduce their risk of cardiovascular events by as much as 40%;the proposed study will adapt ..
  56. ACE Inhibition and Novel Cardiovascular Risk Factors
    Marco Pahor; Fiscal Year: 2004
    b>Angiotensin converting enzyme inhibitors (ACE inhibitors) may prevent cardiovascular events in high risk persons and improve skeletal muscle function in heart failure patients by means of mechanisms that are independent of blood pressure ..
  57. Anisotropic Reinforcement to Improve Post-Infarction LV Function
    Jeffrey W Holmes; Fiscal Year: 2013
    ..Although drugs such as angiotensin converting enzyme (ACE) inhibitors can help reduce post-infarction remodeling, the risk of developing heart failure ..
  58. Labeled inhibitors for angiotensin converting enzyme
    John Babich; Fiscal Year: 2004
    ..Large clinical trials using angiotensin-converting enzyme (ACE) inhibitors have proven to reduce the risk of morbidity and mortality in patients with coronary artery disease and ..
  59. ACE inhibitor and prevention of diabetic retinopathy
    Jinzhong Zhang; Fiscal Year: 2004
    Several clinical studies have detected an unexpected inhibition of diabetic retinopathy by ACE (angiotensin-converting enzyme) inhibitors, and the mechanism for this action is unclear...
  60. Prevention of Diabetic Neuropathy with ACE Inhibitors
    Mark Yorek; Fiscal Year: 2007
    ..or Zucker Diabetic Fatty (ZDF) rats, an animal model for Type II diabetes, with Enalapril, an angiotensin converting enzyme (ACE) inhibitor, or AVE7688, a vasopeptidase inhibitor, which inhibits both ACE and neutral ..
  61. Genetic determinants of aldosterone escape in heart failure
    Larisa Cavallari; Fiscal Year: 2009
    ..b>Angiotensin converting enzyme (ACE) inhibitors are cornerstone therapy to suppress the RAAS;however, aldosterone levels rise in a ..
  62. Maximize RAS Blockade in Diabetic Nephropathy
    Timothy Meyer; Fiscal Year: 2003
    Blockade of the renin-angiotensin system (RAS) by inhibition of angiotensin converting enzyme (ACE) reduces proteinuria and slows loss of renal function in patients with diabetic nephropathy...
  63. ANGIOTENSIN II--AN INTRAOVARIAN REGULATORY PEPTIDE
    Ahsan Husain; Fiscal Year: 1992
    ..the secretion of estradiol-17 beta from the rat ovary; and 2) that both Ang II and angiotensin I converting enzyme (ACE) are present in the rat ovary...
  64. SEPARATE ACTIVE DOMAINS OF ANGIOTENSIN CONVERTING ENZYME
    ERVIN ERDOS; Fiscal Year: 2000
    DESCRIPTION: (Adapted from the Applicant's Abstract) Angiotensin I-converting enzyme (kininase II; ACE) has two active centers in two homologous domains, named N- or C- domain according to their position in the sequence...
  65. EXPRESSION OF ACE IN SHEAR STRESSED ENDOTHELIAL CELLS
    KAREN FRASIER SCOTT; Fiscal Year: 1990
    ..We propose that angiotensin I-converting enzyme (ACE) plays a pivotal role in the modulation of vascular wall tonus, and that the expression and activity of this enzyme ..
  66. ACE GENOTYPE, BP, AND EXERCISE TRAINING IN HYPERTENSIVES
    JAMES HAGBERG; Fiscal Year: 2004
    ..Our preliminary data suggest that angiotensin converting enzyme (ACE) gentoype affects the systolic and diastolic BP reductions that occur in hypertensives with ..
  67. Hypertension and Collagen: Effect of Ac-SDKP
    Nour Eddine Rhaleb; Fiscal Year: 2010
    ..Blocking angiotensin-converting enzyme (ACE) decreases angiotensin II (Ang II) and increases kinins, leading to decreased cardiovascular inflammation, ..
  68. ACE2 as a target for pulmonary hypertension therapeutics
    MOHAN K contact RAIZADA; Fiscal Year: 2010
    ..b>Angiotensin converting enzyme 2 (ACE2) is the key enzyme of the renin-angiotensin system present in endothelial cells...
  69. Angiotensin and Neurodegeneration
    PATRICIA SONSALLA; Fiscal Year: 2009
    ..Inhibition of the brain angiotensin converting enzyme (ACE), the activity of which is elevated in the cerebrospinal fluid of PD patients, is documented to ..
  70. CLEAVAGE-SECRETION OF ANGIOTENSIN-CONVERTING ENZYME
    Indira Sen; Fiscal Year: 2003
    DESCRIPTION (Adapted from the application): Angiotensin-converting enzyme (ACE) is a key component of the renin-angiotensin system that regulates blood pressure...
  71. THE RENAL-SPECIFIC EXPRESSION OF ACE
    Kenneth Bernstein; Fiscal Year: 2004
    ..Our group has created mice that lack ACE. These animals have very low systolic blood pressures and are unable to effectively concentrate urine...
  72. Impact of statins and ACE inhibitors on outcomes for pneumonia and sepsis
    Eric Mortensen; Fiscal Year: 2009
    ..may lead to septic shock or acute respiratory distress syndrome, and several common medications including statins, ACE inhibitors, and angiotensin receptor blockers (ARBs) have been demonstrated to reduce systemic inflammation due to ..
  73. Absorption, distribution, metabolism, excretion (ADME) of chemicals in mammals
    Rochelle W Tyl; Fiscal Year: 2009
    ..During the current year, studies on 1,3-dichloro-2-propanol (DCP), dimethylamineborane (DMAB), 2-methoxy-4-nitroaniline (MNA), and n-butylparaben (BPB) were undertaken while ..

Patents1

  1. NUCLEIC ACID CODING FOR THE HUMAN TESTICULAR ANGIOTENSIN CONVERSION ENZYME (ECA) AND ITS APPLICATIONS, IN PARTICULAR FOR THE IN VITRO DETECTION OF SAID ENZYME IN THE ORGANISM
    Patent Number: WO9100354-A1; Date:1991-01-10