ACAD11

Summary

Gene Symbol: ACAD11
Description: acyl-CoA dehydrogenase family member 11
Alias: ACAD-11, acyl-CoA dehydrogenase family member 11, acyl-Coenzyme A dehydrogenase family, member 11
Species: human

Top Publications

  1. pmc Analysis of p53 transactivation domain mutants reveals Acad11 as a metabolic target important for p53 pro-survival function
    Dadi Jiang
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell Rep 10:1096-109. 2015
  2. doi Identification of the phd gene cluster responsible for phenylpropanoid utilization in Corynebacterium glutamicum
    Nicolai Kallscheuer
    Institute of Bio and Geosciences, IBG 1 Biotechnology, Forschungszentrum Julich, 52425, Julich, Germany
    Appl Microbiol Biotechnol 100:1871-81. 2016
  3. pmc Association of kidney structure-related gene variants with type 2 diabetes-attributed end-stage kidney disease in African Americans
    Meijian Guan
    Center for Genomics and Personalized Medicine Research, Medical Center Boulevard, Wake Forest School of Medicine, Winston Salem, NC, 27157, USA
    Hum Genet 135:1251-1262. 2016
  4. doi A genome-wide assessment of variability in human serum metabolism
    Mun Gwan Hong
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
    Hum Mutat 34:515-24. 2013
  5. doi Candidate genes and single nucleotide polymorphisms associated with variation in residual feed intake in beef cattle
    B K Karisa
    Livestock Gentec, Department of Agriculture, Food and Nutritional Science, 4 10 Agriculture Forestry Center, University of Alberta, Edmonton, AB T6G2P5, Canada
    J Anim Sci 91:3502-13. 2013
  6. ncbi Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method
    Osamu Ohara
    Department of Human Gene Research, Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
    DNA Res 9:47-57. 2002
  7. ncbi Proteomic comparison of Mycobacterium avium subspecies paratuberculosis grown in vitro and isolated from clinical cases of ovine paratuberculosis
    Valerie Hughes
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik EH26 0PZ, UK
    Microbiology 153:196-205. 2007
  8. ncbi IBR3, a novel peroxisomal acyl-CoA dehydrogenase-like protein required for indole-3-butyric acid response
    Bethany K Zolman
    Department of Biology, University of Missouri St Louis, One University Boulevard, R223 Research Building, St Louis, MO 63121, USA
    Plant Mol Biol 64:59-72. 2007
  9. pmc Biochemical and genetic investigation of initial reactions in aerobic degradation of the bile acid cholate in Pseudomonas sp. strain Chol1
    Antoinette Birkenmaier
    Universitat Konstanz, Fachbereich Biologie, Mikrobielle Oekologie, Fach M654, D 78457, Konstanz, Germany
    J Bacteriol 189:7165-73. 2007
  10. pmc Acyl-CoA dehydrogenases: Dynamic history of protein family evolution
    Zuzana Swigonova
    Department of Pediatrics, University of Pittsburgh, Children s Hospital of Pittsburgh, PA 15213, USA
    J Mol Evol 69:176-93. 2009

Patents

  1. 62113, a human acyl-coa dehydrogenase family member and uses therefor

Scientific Experts

  • O Ohara
  • Valerie Hughes
  • Bethany K Zolman
  • Meijian Guan
  • Nicolai Kallscheuer
  • Dadi Jiang
  • Mun Gwan Hong
  • B K Karisa
  • Miao He
  • Jerry Vockley
  • Al Walid Mohsen
  • Zuzana Swigonova
  • Antoinette Birkenmaier
  • Jan Marienhagen
  • Stephan Noack
  • Barry I Freedman
  • Jason A Bonomo
  • Michael Vogt
  • Mary Stromberg
  • Michael Bott
  • Pamela J Hicks
  • Karin Krumbach
  • Latchezar Dimitrov
  • Donald W Bowden
  • Jun Ma
  • Jacob M Keaton
  • Jannick Kappelmann
  • Poorva Mudgal
  • Maggie C Y Ng
  • Colleen A Brady
  • John M Abrams
  • Laura D Attardi
  • Daniela Kenzelmann Broz
  • Amato J Giaccia
  • Kathryn T Bieging
  • Edward L LaGory
  • Nichole Link
  • Z Wang
  • Patrik K E Magnusson
  • Henrik Gronberg
  • J Thomson
  • P Stothard
  • William Isaacs
  • S S Moore
  • Jessica E Prenni
  • G S Plastow
  • Lilly S Zheng
  • Corey Broeckling
  • Robert Karlsson
  • Erik Ingelsson
  • Jianfeng Xu
  • Jonathan A Prince
  • Matthew R Lewis
  • Yudi Pawitan
  • Fredrik Wiklund
  • Regina Ensenauer
  • Zhengtong Pei
  • Paul Watkins
  • Paul P Van Veldhoven
  • Geoffrey Murdoch
  • Bodo Philipp
  • René Schoenenberger
  • Janosch Klebensberger
  • Heiko M Moeller
  • Marc J F Suter
  • Johannes Holert
  • Henrike Erdbrink
  • Anke Friemel

Detail Information

Publications11

  1. pmc Analysis of p53 transactivation domain mutants reveals Acad11 as a metabolic target important for p53 pro-survival function
    Dadi Jiang
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell Rep 10:1096-109. 2015
    ..One such gene, Acad11, encoding a protein involved in fatty acid oxidation, is required for efficient OXPHOS and cell survival upon ..
  2. doi Identification of the phd gene cluster responsible for phenylpropanoid utilization in Corynebacterium glutamicum
    Nicolai Kallscheuer
    Institute of Bio and Geosciences, IBG 1 Biotechnology, Forschungszentrum Julich, 52425, Julich, Germany
    Appl Microbiol Biotechnol 100:1871-81. 2016
    ..glutamicum...
  3. pmc Association of kidney structure-related gene variants with type 2 diabetes-attributed end-stage kidney disease in African Americans
    Meijian Guan
    Center for Genomics and Personalized Medicine Research, Medical Center Boulevard, Wake Forest School of Medicine, Winston Salem, NC, 27157, USA
    Hum Genet 135:1251-1262. 2016
    ..Removal of APOL1 renal-risk genotype carriers revealed additional association at five loci, TTC21B, COL4A3, NPHP3-ACAD11, CLDN8, and ARHGAP24 (P corr < 0.05)...
  4. doi A genome-wide assessment of variability in human serum metabolism
    Mun Gwan Hong
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
    Hum Mutat 34:515-24. 2013
    ..Biological pathway analysis implicated ACADM, ACADS, ACAD8, ACAD10, ACAD11, and ACOXL, reflecting significant enrichment of genes with acyl-CoA dehydrogenase activity...
  5. doi Candidate genes and single nucleotide polymorphisms associated with variation in residual feed intake in beef cattle
    B K Karisa
    Livestock Gentec, Department of Agriculture, Food and Nutritional Science, 4 10 Agriculture Forestry Center, University of Alberta, Edmonton, AB T6G2P5, Canada
    J Anim Sci 91:3502-13. 2013
    ..for each genotype were estimated and an over-dominance effect was observed for the SNP located in the GHR, CAST, ACAD11 and UGT3A1 genes. In addition, 2 other SNP showed a dominance effect and 3 genes had an additive effect...
  6. ncbi Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method
    Osamu Ohara
    Department of Human Gene Research, Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
    DNA Res 9:47-57. 2002
    ..Taking all these results together, we here conclude that this new method for the construction of size-fractionated cDNA libraries makes it possible to analyze cDNAs efficiently and comprehensively...
  7. ncbi Proteomic comparison of Mycobacterium avium subspecies paratuberculosis grown in vitro and isolated from clinical cases of ovine paratuberculosis
    Valerie Hughes
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik EH26 0PZ, UK
    Microbiology 153:196-205. 2007
    ..Most of the proteins identified do not have obviously related functions; however, ArgG and RocA function in the same pathway, and may have a concerted action for energy production in vivo...
  8. ncbi IBR3, a novel peroxisomal acyl-CoA dehydrogenase-like protein required for indole-3-butyric acid response
    Bethany K Zolman
    Department of Biology, University of Missouri St Louis, One University Boulevard, R223 Research Building, St Louis, MO 63121, USA
    Plant Mol Biol 64:59-72. 2007
    ..Based on the singular defect of this mutant in responding to IBA, we propose that IBR3 may act directly in the oxidation of IBA to IAA...
  9. pmc Biochemical and genetic investigation of initial reactions in aerobic degradation of the bile acid cholate in Pseudomonas sp. strain Chol1
    Antoinette Birkenmaier
    Universitat Konstanz, Fachbereich Biologie, Mikrobielle Oekologie, Fach M654, D 78457, Konstanz, Germany
    J Bacteriol 189:7165-73. 2007
    ..In addition, the first bacterial gene encoding an enzyme for a specific reaction step in side chain degradation of steroid compounds was identified, and it showed a high degree of similarity to genes in other steroid-degrading bacteria...
  10. pmc Acyl-CoA dehydrogenases: Dynamic history of protein family evolution
    Zuzana Swigonova
    Department of Pediatrics, University of Pittsburgh, Children s Hospital of Pittsburgh, PA 15213, USA
    J Mol Evol 69:176-93. 2009
    ..were unique to the eukaryotic domain: one resulted in the VLCAD and ACAD9 paralogs and another in the ACAD10 and ACAD11 paralogs...
  11. pmc Identification and characterization of new long chain acyl-CoA dehydrogenases
    Miao He
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Mol Genet Metab 102:418-29. 2011
    ..Here we characterize two new ACADs, ACAD10 and ACAD11, both with significant expression in human brain...

Patents1

  1. 62113, a human acyl-coa dehydrogenase family member and uses therefor
    Patent Number: EP1331227-A1; Date:2003-07-30