ABO

Summary

Gene Symbol: ABO
Description: ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase
Alias: A3GALNT, A3GALT1, GTB, NAGAT, histo-blood group ABO system transferase, ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase), B(A) alpha-1,3-galactosyltransferase, histo-blood group A2 transferase
Species: human

Top Publications

  1. ncbi [Prevention of ABO-incompatible transfusion]
    Yasuhiko Fujii
    Department of Blood Transfusion, Yamaguchi University Hospital, Ube 755 8505
    Masui 60:47-54. 2011
  2. ncbi ABO transcript levels in peripheral blood and erythropoietic culture show different allele-related patterns independent of the CBF/NF-Y enhancer motif and multiple novel allele-specific variations in the 5'- and 3'-noncoding regions
    Britt Thuresson
    Department of Laboratory Medicine, Lund University and Blood Center, Lund University Hospital, Lund, Sweden
    Transfusion 48:493-504. 2008
  3. ncbi Uridine diphosphate-N-acetyl-D-galactosamine: D-galactose alpha-3-N-acetyl-D-galactosaminyltransferase, a product of the gene that determines blood type A in man
    A Kobata
    J Biol Chem 245:1484-90. 1970
  4. ncbi Human histo-blood group A2 transferase coded by A2 allele, one of the A subtypes, is characterized by a single base deletion in the coding sequence, which results in an additional domain at the carboxyl terminal
    F Yamamoto
    Biomembrane Institute, Seattle, WA 98119
    Biochem Biophys Res Commun 187:366-74. 1992
  5. ncbi Cloning and characterization of DNA complementary to human UDP-GalNAc: Fuc alpha 1----2Gal alpha 1----3GalNAc transferase (histo-blood group A transferase) mRNA
    F Yamamoto
    Biomembrane Institute, University of Washington, Seattle 98119
    J Biol Chem 265:1146-51. 1990
  6. ncbi Molecular genetic basis of the histo-blood group ABO system
    F Yamamoto
    Biomembrane Institute, Seattle, Washington
    Nature 345:229-33. 1990
  7. ncbi Genomic organization of human histo-blood group ABO genes
    F Yamamoto
    Department of Molecular Biology, Biomembrane Institute, Seattle, WA 98119, USA
    Glycobiology 5:51-8. 1995
  8. ncbi Extensive polymorphism of ABO blood group gene: three major lineages of the alleles for the common ABO phenotypes
    K Ogasawara
    Japanese Red Cross Tokyo Metropolitan Blood Center, Japan
    Hum Genet 97:777-83. 1996
  9. ncbi Molecular genetic analysis of variant phenotypes of the ABO blood group system
    K Ogasawara
    Japanese Red Cross Tokyo Metropolitan Blood Center, Japan
    Blood 88:2732-7. 1996
  10. ncbi Recombination and gene conversion-like events may contribute to ABO gene diversity causing various phenotypes
    K Ogasawara
    Japanese Red Cross Central Blood Center, Tokyo
    Immunogenetics 53:190-9. 2001

Research Grants

  1. ABO ANTIBODIES--PARADIGM FOR HUMAN REPERTOIRE EVOLUTION
    TYLIS CHANG; Fiscal Year: 2000
  2. Improvement in Paired Donation Program
    Stanislaw M Stepkowski; Fiscal Year: 2013
  3. SUPPLY, EVALUATION AND SELECTION OF LIVING RENAL DONORS
    Akinlolu Ojo; Fiscal Year: 2001
  4. BABAK JOHN ORANDI; Fiscal Year: 2014
  5. Donna M Woods; Fiscal Year: 2014
  6. Martin S Zand; Fiscal Year: 2016
  7. Development of a National Incompatible Kidney Transplant Registry
    Robert A Montgomery; Fiscal Year: 2010
  8. Dorry L Segev; Fiscal Year: 2016
  9. Axial Flow Effects in Proximal Tubule
    TONG WANG WANG; Fiscal Year: 2012
  10. Modulation of Outer Membrane Protein Expressin in Helicobacter pylori
    Jay V Solnick; Fiscal Year: 2012

Detail Information

Publications258 found, 100 shown here

  1. ncbi [Prevention of ABO-incompatible transfusion]
    Yasuhiko Fujii
    Department of Blood Transfusion, Yamaguchi University Hospital, Ube 755 8505
    Masui 60:47-54. 2011
    Identification error between patient and blood product" is the main cause of ABO-incompatible blood transfusion, but "Phlebotomy error" also has serious consequences...
  2. ncbi ABO transcript levels in peripheral blood and erythropoietic culture show different allele-related patterns independent of the CBF/NF-Y enhancer motif and multiple novel allele-specific variations in the 5'- and 3'-noncoding regions
    Britt Thuresson
    Department of Laboratory Medicine, Lund University and Blood Center, Lund University Hospital, Lund, Sweden
    Transfusion 48:493-504. 2008
    Mechanisms regulating the ABO gene are unclear, especially in the hematopoietic compartment. The number of 43-bp repeats in the CBF/NF-Y-binding enhancer region is considered to have a major influence on transcription.
  3. ncbi Uridine diphosphate-N-acetyl-D-galactosamine: D-galactose alpha-3-N-acetyl-D-galactosaminyltransferase, a product of the gene that determines blood type A in man
    A Kobata
    J Biol Chem 245:1484-90. 1970
  4. ncbi Human histo-blood group A2 transferase coded by A2 allele, one of the A subtypes, is characterized by a single base deletion in the coding sequence, which results in an additional domain at the carboxyl terminal
    F Yamamoto
    Biomembrane Institute, Seattle, WA 98119
    Biochem Biophys Res Commun 187:366-74. 1992
    ..identified a possible mutation which characterizes A2 alleles (a minor subtype of A) at the human histo-blood group ABO locus based on polymerase chain reaction (PCR) of genomic DNA, followed by nucleotide sequencing of the amplified ..
  5. ncbi Cloning and characterization of DNA complementary to human UDP-GalNAc: Fuc alpha 1----2Gal alpha 1----3GalNAc transferase (histo-blood group A transferase) mRNA
    F Yamamoto
    Biomembrane Institute, University of Washington, Seattle 98119
    J Biol Chem 265:1146-51. 1990
    ..No restriction fragment length polymorphism was found to correlate with ABO blood group type...
  6. ncbi Molecular genetic basis of the histo-blood group ABO system
    F Yamamoto
    Biomembrane Institute, Seattle, Washington
    Nature 345:229-33. 1990
    The histo-blood group ABO, the major human alloantigen system, involves three carbohydrate antigens (ABH)...
  7. ncbi Genomic organization of human histo-blood group ABO genes
    F Yamamoto
    Department of Molecular Biology, Biomembrane Institute, Seattle, WA 98119, USA
    Glycobiology 5:51-8. 1995
    We have isolated human genomic DNA clones encompassing 30 kbp of the histo-blood group ABO locus. The locations of the exons have been mapped and the nucleotide sequences of the exon-intron boundaries have been determined...
  8. ncbi Extensive polymorphism of ABO blood group gene: three major lineages of the alleles for the common ABO phenotypes
    K Ogasawara
    Japanese Red Cross Tokyo Metropolitan Blood Center, Japan
    Hum Genet 97:777-83. 1996
    Polymorphism of the ABO blood group gene was investigated in 262 healthy Japanese donors by a polymerase chain reactions-single-strand conformation polymorphism (PCR-SSCP) method, and 13 different alleles were identified...
  9. ncbi Molecular genetic analysis of variant phenotypes of the ABO blood group system
    K Ogasawara
    Japanese Red Cross Tokyo Metropolitan Blood Center, Japan
    Blood 88:2732-7. 1996
    b>ABO is clinically the most important blood group system in transfusion medicine and includes many variant phenotypes...
  10. ncbi Recombination and gene conversion-like events may contribute to ABO gene diversity causing various phenotypes
    K Ogasawara
    Japanese Red Cross Central Blood Center, Tokyo
    Immunogenetics 53:190-9. 2001
    We identified five different alleles, tentatively named ABO*O301, *0302, *R102, *R103, and *A110, in Japanese individuals possessing the blood group O phenotype...
  11. ncbi Genomic analysis of clinical samples with serologic ABO blood grouping discrepancies: identification of 15 novel A and B subgroup alleles
    M L Olsson
    Blood Centre, University Hospital, Lund, Sweden
    Blood 98:1585-93. 2001
    Since the cloning in 1990 of complementary DNA corresponding to messenger RNA transcribed at the blood group ABO locus, polymorphisms and phenotype-genotype correlations have been reported by several investigators...
  12. ncbi Alternative promoter identified between a hypermethylated upstream region of repetitive elements and a CpG island in human ABO histo-blood group genes
    Yoshihiko Kominato
    First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Faculty of Medicine, Toyama 930 0194, Japan
    J Biol Chem 277:37936-48. 2002
    We have studied the expression of human histo-blood group ABO genes during erythroid differentiation, using an ex vivo culture of AC133(-)CD34(+) cells obtained from peripheral blood...
  13. ncbi The structural basis for specificity in human ABO(H) blood group biosynthesis
    Sonia I Patenaude
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, K1H 8M5 Canada
    Nat Struct Biol 9:685-90. 2002
    ..GTA) uses a UDP-GalNAc donor to convert the H-antigen acceptor to the A antigen, whereas a galactosyltransferase (GTB) uses a UDP-galactose donor to convert the H-antigen acceptor to the B antigen...
  14. ncbi Red blood cell polymorphisms in relation to Plasmodium falciparum asymptomatic parasite densities and morbidity in Senegal
    Florence Migot-Nabias
    Institut de recherche pour le developpement IRD, Unité de Recherche 010 Santé de la mère et de l enfant en milieu tropical, BP 1386 Dakar, Senegal
    Microbes Infect 8:2352-8. 2006
    ..The pressure exerted in the area by other non-malarial infectious diseases as well as the genetic heterogeneity of circulating parasites may also contribute to these observations...
  15. ncbi ABO blood group determines plasma von Willebrand factor levels: a biologic function after all?
    P Vince Jenkins
    National Center for Hereditary Coagulation Disorders and Department of Haematology, Institute of Molecular Medicine, St James s Hospital and Trinity College, Dublin, Ireland
    Transfusion 46:1836-44. 2006
    For many years, an association between ABO histo-blood group and risk of thrombosis has been recognized...
  16. pmc Common variation in the ABO glycosyltransferase is associated with susceptibility to severe Plasmodium falciparum malaria
    Andrew E Fry
    The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Hum Mol Genet 17:567-76. 2008
    There is growing epidemiological and molecular evidence that ABO blood group affects host susceptibility to severe Plasmodium falciparum infection...
  17. pmc Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women
    Guillaume Pare
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000118. 2008
    ..We also find that a single SNP (rs507666, P = 5.1x10(-29)) at the ABO (9q34.2) locus is highly correlated with sICAM-1 concentrations...
  18. pmc Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes
    Xin Yuan
    Genetics Division, GlaxoSmithKline, King of Prussia, PA 19406, USA
    Am J Hum Genet 83:520-8. 2008
    ..In addition, we confirmed the associations between the GGT1 locus and GGT levels and between the ABO locus and ALP levels...
  19. doi Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach
    David Alexandre Tregouet
    INSERM, Unite Mixte de Recherche S, Paris, France
    Blood 113:5298-303. 2009
    ..Only 3 SNPs located in the FV and ABO blood group genes were found associated with VTE at a genome-wide significant level of 1.7 x 10(-7)...
  20. pmc Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin
    Andrew D Paterson
    Hospital for Sick Children, Toronto, Ontario, Canada
    Arterioscler Thromb Vasc Biol 29:1958-67. 2009
    ..Although E-selectin levels are heritable, little is known about the specific genetic factors involved. E-selectin levels have been associated with the ABO blood group phenotype.
  21. pmc Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium
    Brian M Wolpin
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Cancer Res 70:1015-23. 2010
    A recent genome-wide association study (PanScan) identified significant associations at the ABO gene locus with risk of pancreatic cancer, but the influence of specific ABO genotypes remains unknown...
  22. pmc Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Hum Mol Genet 19:1856-62. 2010
    ..the Nurses' Health Study, and identified genome-wide significant associations between a cluster of markers at the ABO locus (9q34) and plasma sE-selectin concentration...
  23. pmc Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels
    Maja Barbalic
    Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA
    Hum Mol Genet 19:1863-72. 2010
    ..53 x 10(-23)). Both sP-selectin and sICAM-1 were associated with ABO gene variants (rs579459, P = 1.86 x 10(-41) and rs649129, P = 1...
  24. pmc Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium
    Nicholas L Smith
    Department of Epidemiology, University of Washington, Seattle, Wash 98101, USA
    Circulation 121:1382-92. 2010
    ..Plasma levels of coagulation factors VII (FVII), VIII (FVIII), and von Willebrand factor (vWF) influence risk of hemorrhage and thrombosis. We conducted genome-wide association studies to identify new loci associated with plasma levels...
  25. pmc Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies
    Muredach P Reilly
    Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Lancet 377:383-92. 2011
    ..We tested whether genetic factors distinctly contribute to either development of coronary atherosclerosis or, specifically, to myocardial infarction in existing coronary atherosclerosis...
  26. doi ABO blood group alleles and the risk of pancreatic cancer in a Japanese population
    Makoto Nakao
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Sci 102:1076-80. 2011
    Several studies have investigated a possible association between the ABO blood group and the risk of pancreatic cancer (PC), but this association has not been fully evaluated in Asian populations...
  27. doi A genome-wide association study identifies two new risk loci for Graves' disease
    Xun Chu
    State Key Laboratory of Medical Genomics, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
    Nat Genet 43:897-901. 2011
    ..Moreover, we identified strong associations of TSHR and major histocompatibility complex class II variants with persistently TRAb-positive Graves' disease...
  28. pmc Association of variation at the ABO locus with circulating levels of soluble intercellular adhesion molecule-1, soluble P-selectin, and soluble E-selectin: a meta-analysis
    Stefan Kiechl
    Innsbruck Medical University, Innsbruck, Austria
    Circ Cardiovasc Genet 4:681-6. 2011
    ..adhesion molecule-1, soluble P-selectin, and soluble E-selectin have been associated with variation at the ABO locus...
  29. doi A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population
    Chizu Tanikawa
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Nat Genet 44:430-4, S1-2. 2012
    ..we identified two susceptibility loci at the PSCA gene (encoding prostate stem cell antigen) at 8q24 and at the ABO blood group locus at 9q34...
  30. doi A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk
    Meian He
    MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    Gut 63:143-51. 2014
    ....
  31. ncbi Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid substitutions
    F Yamamoto
    Department of Molecular Biology, Biomembrane Institute, Seattle, Washington 98119
    J Biol Chem 265:19257-62. 1990
    ..The second substitution (glycine in A and serine in B) also affects the specificity. We have also created new enzymes which catalyze the transfer of both GalNAc and Gal, and may provide an explanation of the rare cis-AB phenotype...
  32. ncbi Frequent occurrence of a variant O1 gene at the blood group ABO locus
    M L Olsson
    Blood Centre, University Hospital, Lund, Sweden
    Vox Sang 70:26-30. 1996
    Blood group ABO polymorphism was analysed in genomic DNA isolated from 150 blood donors by restriction endonuclease digestion of three polymerase chain reaction-amplified exons in the ABO genes and by sequencing of randomly selected ..
  33. ncbi Transcription of human ABO histo-blood group genes is dependent upon binding of transcription factor CBF/NF-Y to minisatellite sequence
    Y Kominato
    Toyama Medical and Pharmaceutical University, Faculty of Medicine, Department of Legal Medicine, Toyama, 930 01 Japan
    J Biol Chem 272:25890-8. 1997
    We have studied the transcriptional regulatory mechanism of the human histo-blood group ABO genes, and identified DNA cis-elements and trans-activating protein that control the expression of these genes which are important in blood ..
  34. ncbi Characterization of the human ABO gene promoter in erythroid cell lineage
    Y Hata
    Toyama Medical and Pharmaceutical University, Faculty of Medicine, Department of Legal Medicine, Toyama, Japan
    Vox Sang 82:39-46. 2002
    The human ABO blood group system is important in transfusion and organ transplantation. Although the molecular basis of the ABO gene has been established, recent studies have begun to characterize the mechanism of the ABO gene expression.
  35. ncbi Molecular genetic analysis of the ABO blood group system: 3. A(X) and B(A) alleles
    F Yamamoto
    Department of Molecular Biology, Biomembrane Institute, Seattle, WA 98119
    Vox Sang 64:171-4. 1993
    ..to determine the nucleotide sequences of the coding region in the last two coding exons of the histo-blood group ABO genes from one A(X) and one B(A) individual...
  36. ncbi Molecular analysis of the O alleles at the blood group ABO locus in populations of different ethnic origin reveals novel crossing-over events and point mutations
    M L Olsson
    Blood Centre, University Hospital, Lund, Sweden
    Biochem Biophys Res Commun 234:779-82. 1997
    The blood group ABO genotypes of 138 group O individuals with three different ethnic origins in Brazil were determined, including Whites, Blacks and Amerindians...
  37. ncbi Heterogeneity of the blood group Ax allele: genetic recombination of common alleles can result in the Ax phenotype
    M L Olsson
    Blood Centre, University Hospital, Lund, Sweden
    Transfus Med 8:231-8. 1998
    The Ax phenotype is an important subgroup of the ABO blood group system. Its inheritance does not always follow Mendelian rules and recent studies suggested that different alleles can result in this phenotype...
  38. ncbi Frequency of ABO and Rhesus blood groups in District Swat, Pakistan
    Imranud Din Khattak
    Department of Pathology, Saidu Teaching Hospital Saidu Medical College, Swat, Pakistan
    J Ayub Med Coll Abbottabad 20:127-9. 2008
    Up till now about 400 red cells antigen have been identified. The majority are inherited by Mendelian Fashion. The ABO blood group system was first to be identified and RH blood group system was the 4th one, both are most important for ..
  39. pmc ABO blood group system and placental malaria in an area of unstable malaria transmission in eastern Sudan
    Ishag Adam
    Department of Obstetrics and Gynecology, Faculty of Medicine University of Khartoum, Sudan
    Malar J 6:110. 2007
    ..Understanding the pathogenesis of malaria in pregnancy and its consequences for both the mother and the baby is fundamental for improving malaria control in pregnant women...
  40. ncbi Association analysis of 24-h blood pressure records with I/D ACE gene polymorphism and ABO blood group system
    A Vasku
    Institute of Pathological Physiology, Medical Faculty of Masaryk University, Brno, Czech Republic
    Physiol Res 48:99-104. 1999
    ..24-h blood pressure parameters, insertion/deletion polymorphism of the angiotensin I converting enzyme gene and the ABO blood group system in a sample of the general Czech population...
  41. doi Frequency of ABO blood group system polymorphisms in Plasmodium falciparum malaria patients and blood donors from the Brazilian Amazon region
    D B Carvalho
    Universidade Estadual Paulista Julio de Mesquita Filho, Sao Jose do Rio Preto, SP, Brasil
    Genet Mol Res 9:1443-9. 2010
    We investigated the ABO genotypes and heterogeneity of the O alleles in Plasmodium falciparum-infected and non-infected individuals from the Brazilian Amazon region. Sample collection took place from May 2003 to August 2005, from P...
  42. ncbi The ABO blood group system and Plasmodium falciparum malaria
    Christine M Cserti
    University Health Network, Toronto General Hospital Blood Transfusion Laboratory, Toronto, Ontario, Canada
    Blood 110:2250-8. 2007
    In the century since the discovery of the ABO blood groups, numerous associations between ABO groups and disease have been noted. However, the selection pressures defining the ABO distributions remain uncertain...
  43. ncbi Therapeutic apheresis therapy for ABO-incompatible renal transplantations
    Hideki Ishida
    Department of Urology, Division of Blood Purification, Tokyo Women s Medical University, Tokyo, Japan
    Ther Apher Dial 7:520-8. 2003
    The most important transplantation antigen system for organ transplantation is the ABO blood group system. Crossing the blood barrier is usually not done except in emergency cases such as liver transplantations for fulminant hepatitis...
  44. doi [Application of flow cytometry to detect ABO blood group antibody levels in rhesus monkeys and cynomolgus monkeys]
    Chi Zhang
    Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Organ Transplantation, Ministry of Education, Wuhan 430030, China
    Dongwuxue Yanjiu 32:56-61. 2011
    Similar to humans, most of non-human primates also contain the ABO blood group system. In this study, we sought to evaluate the ABO antibody (Ab) levels in monkeys using a modified flow cytometry method (FCM)...
  45. ncbi Molecular genetic analysis for Ax phenotype of the ABO blood group system in Chinese
    Z H Deng
    Shenzhen Institute of Transfusion Medicine, Shenzhen, Guangdong, China
    Vox Sang 89:251-6. 2005
    ..To elucidate the molecular genetic background of the Ax phenotype in the Chinese population...
  46. ncbi [Erythropoietin: biochemical characteristics, biologic effects, indications and results of use in hematology]
    A M Marmont
    II Divisione di Ematologia, Ospedale San Martino, Genova, Italy
    Tumori 83:S3-15. 1997
    ..However, the most important results have been obtained in post-major-ABO incompatible PRCA, when the removal of the recipient's isohemagglutinins does not resolve the anemia...
  47. pmc Blood groups, serum cholesterol, serum uric acid, blood pressure, and obesity in adolescents
    R F Gillum
    Office of Analysis and Epidemiology, National Center for Health Statistics, Hyattsville, Maryland 20782
    J Natl Med Assoc 83:682-8. 1991
    ..In a nationwide sample of more than 6000 black and white adolescents aged 12 to 17 years, ABO blood group, haptoglobin phenotype, selected other genetic markers of blood and secretions, and coronary risk ..
  48. ncbi Optimal blood grouping and antibody screening for safe transfusion
    T Makarovska-Bojadzieva
    Blood Transfusion Institute, Skopje, R Macedonia
    Prilozi 30:119-28. 2009
    ..The need for routine typing of certain blood group antigens in addition to ABO and RhD was also evaluated. Material and method...
  49. pmc National tuberculosis programme review: experience over the period 1990-95
    A Pio
    National Programme Support, Global Tuberculosis Programme, World Health Organization, Geneva, Switzerland
    Bull World Health Organ 75:569-81. 1997
    Since 1990 the WHO Global Tuberculosis Programme (GTB) has promoted the revision of national tuberculosis programmes to strengthen the focus on directly observed treatment, short-course (DOTS) and close monitoring of treatment outcomes...
  50. doi Hot topic: Enhancing omega-3 fatty acids in milk fat of dairy cows by using stearidonic acid-enriched soybean oil from genetically modified soybeans
    G Bernal-Santos
    Department of Animal Science, Cornell University, Ithaca, NY 14853, USA
    J Dairy Sci 93:32-7. 2010
    ..design to the following treatments: 1) control (no oil infusion); 2) abomasal infusion of SDA-enhanced SBO (SDA-abo); and 3) ruminal infusion of SDA-enhanced SBO (SDA-rum). The SDA-enhanced SBO contained 27.1% SDA, 10...
  51. ncbi The relationship of blood-group type to American cutaneous leishmaniasis
    P Esterre
    Immunologie Parasitaire, , Cayenne, France
    Ann Trop Med Parasitol 83:345-8. 1989
    ..braziliensis guyanensis, by comparing the distribution of blood groups (ABO and Rhesus) among 96 patients in French Guiana with that among 1945 healthy controls...
  52. ncbi Long-term results of ABO-incompatible living kidney transplantation: a single-center experience
    K Tanabe
    Department of Urology, Kidney Center, Tokyo Women s Medical College, Japan
    Transplantation 65:224-8. 1998
    ..These circumstances have forced a widening of indications for kidney transplantation. For this purpose, ABO-incompatible living kidney transplantations (LKTs) have been performed...
  53. ncbi An early (sixth-hour) serum bilirubin measurement is useful in predicting the development of significant hyperbilirubinemia and severe ABO hemolytic disease in a selective high-risk population of newborns with ABO incompatibility
    S Umit Sarici
    Division of Neonatology, Department of Pediatrics, Hacettepe University Faculty of Medicine Ihsan Doğramaci Children s Hospital, Ankara, Turkey
    Pediatrics 109:e53. 2002
    In the era of early discharge of newborns from the hospital, newborns with ABO incompatibility are at especially greater risk for developing a subsequent significant hyperbilirubinemia because some of these infants also may present with ..
  54. ncbi An extensive polymerase chain reaction-allele-specific polymorphism strategy for clinical ABO blood group genotyping that avoids potential errors caused by null, subgroup, and hybrid alleles
    Bahram Hosseini-Maaf
    Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University and Blood Center, Lund University Hospital, Lund, Sweden
    Transfusion 47:2110-25. 2007
    b>ABO genotyping is complicated by the remarkable diversity at the ABO locus. Recombination or gene conversion between common alleles may lead to hybrids resulting in unexpected ABO phenotypes...
  55. ncbi Antigen structure and genetic basis of histo-blood groups A, B and O: their changes associated with human cancer
    S Hakomori
    Pacific Northwest Research Institute, 720 Broadway, 98122 4327, Seattle, WA 98122 4327, USA
    Biochim Biophys Acta 1473:247-66. 1999
    Three areas of research involved in blood group (or histo-blood group) ABO antigens and their genes, developed by our research group, are reviewed: (1) Antigen structures...
  56. ncbi ABO reverse grouping: effect of varying concentrations of the enzyme bromelain
    L E Rookard
    Donor Testing Centre, National Blood Service, Brentwood, Essex, UK
    Br J Biomed Sci 66:93-7. 2009
    ..b>ABO antibodies are the most clinically significant...
  57. ncbi Xenotransplantation and ABO incompatible transplantation: the similarities they share
    Uri Galili
    Department of Medicine, University of Massachusetts Medical School, LRB, Worcester, MA 01605, USA
    Transfus Apher Sci 35:45-58. 2006
    Transplantation of kidney allografts across the ABO barrier has been feasible with the development of technologies for removal of anti-blood group antibodies from the circulation of the recipent...
  58. ncbi Successful A1-to-O ABO-incompatible kidney transplantation after a preconditioning regimen consisting of anti-CD20 monoclonal antibody infusions, splenectomy, and double-filtration plasmapheresis
    Tokihiko Sawada
    Tokyo Women s Medical University, Kidney Center, Department of Surgery, Tokyo, Japan
    Transplantation 74:1207-10. 2002
    b>ABO-incompatible kidney transplantations require the anti-ABO antibody titer to be reduced to below 1:16 before transplantation...
  59. doi The science and manufacturing behind botulinum neurotoxin type A-ABO in clinical use
    Mitchell S Wortzman
    Medicis Pharmaceutical Corp, Scottsdale, AZ, USA
    Aesthet Surg J 29:S34-42. 2009
    ..Now, a new botulinum neurotoxin type A formulation (BoNTA-ABO; Dysport [abobotulinumtoxinA]; Medicis Aesthetics, Scottsdale, AZ) has been made available in the United States and ..
  60. doi Maternal fetal interaction in the ABO system: A comparative analysis of healthy mother and couples with spontaneous abortion in Bengalee population
    Arup Ratan Bandyopadhyay
    Department of Anthropology, University of Calcutta, Kolkata, India
    Am J Hum Biol 23:76-9. 2011
    ..Actual studies on the products of conception, living, or dead (aborted material) of these couples essential for understanding of process of selective elimination of the alleles...
  61. doi Detection of IgG anti-A/B must be essential for safe transfusion support in patients undergoing ABO incompatible allogeneic HSCT
    Feng Liu
    Department of Blood Transfusion, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, 430022, No 1277, Jiefang Avenue, Wuhan, Hubei Province, PR China
    Transfus Apher Sci 44:123-7. 2011
    Recipients of ABO incompatible allogeneic HSCT present with unusual ABO groups and crossmatch problems accompanied by change of the ABO group from that of the host to the donor...
  62. ncbi Present status of ABO-incompatible kidney transplantation in Japan
    Kota Takahashi
    Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Xenotransplantation 13:118-22. 2006
    We have been making continuous efforts in ABO-incompatible kidney transplantation since 1989 to expand the opportunities for kidney transplantation from living donors in Japan.
  63. ncbi [Distribution of the ABO, Rh, MNSs, Kell and Duffy blood group antigens in the population of Vojvodina]
    Svetlana Vojvodić
    Zavod za transfuziju krvi, 21000 Novi Sad, Hajduk Veljkova 9a
    Med Pregl 56:173-7. 2003
    ..erythrocyte blood group antigen polymorphisms and genetic variability in population of Vojvodina was performed by investigating gene and genotype frequencies which determine antigens of ABO, Rh, MNSs, Kell and Duffy blood-group systems.
  64. ncbi ABO incompatible kidney transplantation - an analysis of UNOS Registry data
    Yasuro Futagawa
    Terasaki Foundation Laboratory, Los Angeles, CA 90064, USA
    Clin Transplant 20:122-6. 2006
    The ABO incompatible kidney transplants have been performed successfully from large numbers of living donors and some blood type A2 deceased donors...
  65. ncbi ABO-incompatible kidney transplantation using antigen-specific immunoadsorption and rituximab: a single center experience
    Johannes Donauer
    Department of Nephrology, University Hospital Freiburg, Freiburg, Germany
    Xenotransplantation 13:108-10. 2006
    For years ABO-incompatible kidney transplantations were preferentially performed in Japanese centers...
  66. doi Identification and characterization of major proteins carrying ABO blood group antigens in the human kidney
    Masayuki Tasaki
    Department of Structural Pathology, Institute of Nephrology, Niigata Graduate School of Medical and Dental Sciences, Niigata, Japan
    Transplantation 87:1125-33. 2009
    It is generally admitted that ABO(H) blood group antigens are linked to lipids and proteins...
  67. ncbi A new concept of accommodation in ABO-incompatible kidney transplantation
    Kota Takahashi
    Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Clin Transplant 19:76-85. 2005
    ..antibody-mediated rejection leading to graft loss and the mechanisms of accommodation permitting graft survival in ABO-incompatible kidney transplantation...
  68. pmc Selective population chemotherapy among schoolchildren in Beheira governorate: the UNICEF/Arab Republic of Egypt/WHO Schistosomiasis Control Project
    A el Malatawy
    UNICEF, Cairo, Egypt
    Bull World Health Organ 70:47-56. 1992
    ..40 mg per kg body weight), which was offered to 29,365 schoolchildren in Abu El Matameer and 40,241 in Abo Homos districts, Beheira governorate in the Nile delta, reduced the prevalence of schistosomiasis from 75.4% to 40...
  69. ncbi North American pretransfusion testing practices, 2001-2004: results from the College of American Pathologists Interlaboratory Comparison Program survey data, 2001-2004
    Ira A Shulman
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles County USC Medical Center, Los Angeles, California, USA
    Arch Pathol Lab Med 129:984-9. 2005
    ..Regulated tests include determination of ABO group, Rh D type, antibody detection, antibody identification, and crossmatching...
  70. ncbi Blood donor survey in the Isle of Bute
    M M Izatt
    Glasgow and West of Scotland Blood Transfusion Service, Glasgow, Scotland
    Ann Hum Biol 2:289-300. 1975
    The ABO records of 392 blood donors in the Isle of Bute, Scotland, showed a significant excess of group A and decrease of group O compared with data from the adjacent mainland...
  71. ncbi Adult ABO-incompatible liver transplantation, using A and B donors
    Ulrika Skogsberg
    Department of Transplantation and Liver Surgery, Sahlgrenska University Hospital, Goteborg, Sweden
    Xenotransplantation 13:154-9. 2006
    ..This applies in both urgent situations and for elective patients. We report on our experience with ABO-incompatible liver transplantation using A2 and B non-secretor donors here.
  72. doi Wine intake, ABO phenotype, and risk of ischemic heart disease and all-cause mortality: the Copenhagen Male Study--a 16-year follow-up
    Poul Suadicani
    The Copenhagen Male Study, Epidemiological Research Unit, Clinic of Occupational and Environmental Medicine, Bispebjerg University Hospital, Bispebjerg Bakke 23, Copenhagen, Denmark
    Alcohol 42:575-82. 2008
    The association of alcohol intake with ischemic heart disease (IHD) and all-cause mortality may depend on ABO phenotype...
  73. ncbi ABO blood group antigens on human plasma von Willebrand factor after ABO-mismatched bone marrow transplantation
    T Matsui
    Division of Biomedical Polymer Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan
    Blood 94:2895-900. 1999
    ..b>ABO blood group antigens are covalently associated with asparagine-linked sugar chains of plasma vWF...
  74. doi Botulinum neurotoxin type A-ABO (Dysport): clinical indications and practice guide
    Alan Matarasso
    Albert Einstein College of Medicine, New York, NY, USA
    Aesthet Surg J 29:S72-9. 2009
    The key points to remember about abobotulinumtoxinA are as follows: BoNTA-ABO (abobotulinumtoxinA [Dysport]; Medicis Aesthetics, Scottsdale, AZ) and BoNTA-ONA (onabotulinumtoxin A [Botox Cosmetic]; Allergan, Irvine, CA) are both ..
  75. ncbi Multiple dose IVIG treatment in neonatal immune hemolytic jaundice
    G Tanyer
    Department of Pediatrics, Ministry of Health, Ankara Hospital, Turkey
    J Trop Pediatr 47:50-3. 2001
    Isoimmune hemolytic jaundice due to ABO and Rh blood group incompatibility is an important problem in the neonatal period...
  76. ncbi ABO blood-group antigens in oral cancer
    E Dabelsteen
    Department of Oral Diagnostics, School of Dentistry, University of Copenhagen, Nørre Allé 20, DK 2200 Copenhagen N, Denmark
    J Dent Res 84:21-8. 2005
    ..The peripheral part of these cell-surface glycoconjugates often carries carbohydrate structures related to the ABO and Lewis blood-group antigens...
  77. ncbi Clinical features and risk factors of pure red cell aplasia following major ABO-incompatible allogeneic hematopoietic stem cell transplantation
    Kang Er Zhu
    Department of Hematology, First Affiliated Hospital of Jinan University, Guangzhou, People s Republic of China
    Hematology 12:117-21. 2007
    ..risk factors, clinical outcome, management and prevention of pure red cell aplasia (PRCA) following major ABO-incompatible allogeneic hematopoietic stem cell transplantation (allo-HSCT)...
  78. doi Evaluation of 28 human embryonic stem cell lines for use as unrelated donors in stem cell therapy: implications of HLA and ABO genotypes
    Jeoung Eun Lee
    CHA Stem Cell Institute, CHA University, Seoul, Korea
    Cell Transplant 19:1383-95. 2010
    ..Human leukocyte antigens (HLA) and ABO blood group antigens are important histocompatibility factors in graft rejection...
  79. doi Abomasal or ruminal administration of flax oil and hulls on milk production, digestibility, and milk fatty acid profile of dairy cows
    R Kazama
    Departamento de Zootecnia, Universidade Estadual de Maringa, 87020 900 Maringa, PR, Brazil
    J Dairy Sci 93:4781-90. 2010
    ..hulls administered in the rumen and abomasal infusion of water (RUM/RUM), 2) oil and hulls infused in the abomasum (ABO/ABO), 3) oil administered in the rumen and hulls infused in the abomasum (RUM/ABO), and 4) oil infused in the ..
  80. pmc Rescue from the abnormal oocyte maternal-effect lethality by ABO heterochromatin in Drosophila melanogaster
    J Tomkiel
    Department of Genetics, University of Washington, Seattle 98195
    Genetics 128:583-94. 1991
    The euchromatic maternal-effect mutation abnormal oocyte (abo), of Drosophila melanogaster interacts with regions of heterochromatin known as ABO, which reside on the X, Y and second chromosomes...
  81. ncbi [Impact of vWF gene A1381T polymorphism and ABO blood group on von Willebrand factor level in plasma]
    Zhong hai Yuan
    Department of Hematologic Examination, Faculty of Laboratorial Examination, Jilin Medical College, Jilin 132013, Jilin Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 18:967-71. 2010
    This study was aimed to investigate the impact of vWF A1381T polymorphism (rs216311) and ABO blood group on von Willebrand factor level in plasma. 120 healthy volunteers, aging from 19 to 33 years (average 24) were recruited...
  82. ncbi Analysis of risk factors for the development of GVHD after T cell-depleted allogeneic BMT: effect of HLA disparity, ABO incompatibility, and method of T-cell depletion
    C A Keever-Taylor
    Medical College of Wisconsin Bone Marrow Transplant Program, Department of Medicine, Milwaukee, WI 53226, USA
    Biol Blood Marrow Transplant 7:620-30. 2001
    ..Factors considered in the analysis included patient/donor sex, age, cytomegalovirus (CMV) status, and ABO blood group along with T-cell dose, disease, and disease status, donor relationship, HLA antigen (Ag)mismatch (MM), ..
  83. ncbi [Ascaris lumbricoides: heterogeneity in ABO epithopes expression]
    Patricia Ponce-León
    Departamento de Microbiologia, Area de Parasitología, Universidad Nacional de Rosario, Rosario, Argentina
    Invest Clin 47:385-93. 2006
    Ascaris lumbricoides and its hosts can present the same ABO System epithopes. The aim was to study ABO epithopes expression in A. lumbricoides by Inhibition Agglutination Test using different monoclonal antibodies and policlonal sera...
  84. pmc Prevention of pure red cell aplasia after major or bidirectional ABO blood group incompatible hematopoietic stem cell transplantation by pretransplant reduction of host anti-donor isoagglutinins
    Georg Stussi
    Clinic for Hematology and Laboratory for Transplantation Immunology, Department of Internal Medicine, University Hospital, Zurich, Switzerland
    Haematologica 94:239-48. 2009
    Persistent anti-donor isoagglutinins after major ABO blood group incompatible hematopoietic stem cell transplantation may cause delayed red blood cell engraftment and post-transplant pure red cell aplasia.
  85. ncbi The role of apheresis therapy for ABO incompatible living donor liver transplantation: the Kyoto University experience
    Koichi Kozaki
    Department of Transplantation Immunology, Faculty of Medicine, Kyoto University, Kyoto City, Kyoto, Japan
    Ther Apher Dial 10:441-8. 2006
    ..limited donor supply and because the needs of patients with end-stage liver disease is critical, use of grafts from ABO-incompatible (ABO-I) donors might be the only available option...
  86. doi Double-filtration plasmapheresis
    Kazunari Tanabe
    Department of Urology, Graduate School of Medicine, Tokyo Women s Medical University, Tokyo, Japan
    Transplantation 84:S30-2. 2007
    It is well known that anti-ABO antibodies in the recipient's serum cause hyperacute rejection in ABO-incompatible kidney transplantation...
  87. ncbi The value of transcutaneous method of bilirubin measurement in newborn population with the risk of ABO hemolytic disease
    Dalia Stoniene
    Department of Neonatology, Kaunas University of Medicine, Eiveniu 2, 50009 Kaunas, Lithuania
    Medicina (Kaunas) 45:792-7. 2009
    ..between total serum bilirubin (TSB) and transcutaneous bilirubin (TcB) levels in newborn infants at risk of ABO hemolytic disease. MATERIAL AND METHODS...
  88. ncbi Therapeutic strategy and the role of apheresis therapy for ABO incompatible living donor liver transplantation
    Koichi Kozaki
    Department of Transplantation Immunology, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Ther Apher Dial 9:285-91. 2005
    ..limited donor supply and because the need of patients with end-stage liver disease is critical, use of grafts from ABO-incompatible donors may be the only available option...
  89. ncbi Immune hemolysis following ABO-mismatched stem cell or solid organ transplantation
    Mark H Yazer
    Division of Transfusion Medicine, Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Curr Opin Hematol 14:664-70. 2007
    Limitations in donor availability for stem cell or organ transplantation require that ABO-incompatible donors be used. Crossing ABO lines can have immune consequences characterized by immediate or delayed hemolysis.
  90. pmc The effect of ABO blood incompatibility on corneal transplant failure in conditions with low-risk of graft rejection
    Steven P Dunn
    Michigan Cornea Consultants, PC, Southfield, USA
    Am J Ophthalmol 147:432-438.e3. 2009
    To determine whether corneal graft survival over a 5-year follow-up period was affected by ABO blood type compatibility in participants in the Cornea Donor Study undergoing corneal transplantation principally for Fuchs dystrophy or ..
  91. ncbi Excellent outcome of ABO-incompatible living kidney transplantation under pretransplantation immunosuppression with tacrolimus, mycophenolate mofetil, and steroid
    K Tanabe
    Section of Renal Transplantation Renovascular Surgery, Department of Urology, Tokyo Women s Medical University, Tokyo, Japan
    Transplant Proc 36:2175-7. 2004
    b>ABO-incompatible living kidney transplantation (LKT) has been performed to widen the indications for kidney transplantation...
  92. doi A high-throughput pH indicator assay for screening glycosyltransferase saturation mutagenesis libraries
    Mattias Persson
    Carlsberg Laboratory, Gamle Carlsberg Vej 10, 2500 Valby, Denmark
    Anal Biochem 378:1-7. 2008
    ..for glycosyltransferases that has been developed using the blood group alpha-(1-->3)-galactosyltransferase (GTB) as a model...
  93. pmc ABO phenotypes and malaria related outcomes in mothers and babies in The Gambia: a role for histo-blood groups in placental malaria?
    Maria Paz Loscertales
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK
    Malar J 5:72. 2006
    ..This study analyses the association between ABO blood group phenotypes in relation to placental malaria pathology.
  94. doi [ABO incompatible living donor kidney transplantation: a dream come true. Experience of Hospital Clínic of Barcelona]
    F Oppenheimer
    Unidad de Trasplnte Renal, Servicio de Nefrología y Trasplnte Renal, Hospital Clinic, Barcelona, Spain
    Nefrologia 30:54-63. 2010
    ..However, there are a group of patients with ABO incompatibility, making impossible the transplant until now...
  95. ncbi Development of non-ABO RBC alloantibodies in patients undergoing allogeneic HPC transplantation. Is ABO incompatibility a predisposing factor?
    J de la Rubia
    Department of Hematology, La Fe University Hospital, Valencia, Spain
    Transfusion 41:106-10. 2001
    Data from the appearance of RBC antibodies other than ABO in patients undergoing HPC transplantation are limited.
  96. ncbi Evaluation of polyethylene terephthalate for ABO and Rh typing and alloantibody screening
    D R Anderson
    Departments of Medicine and Pathology, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia, Canada
    Transfusion 40:669-72. 2000
    ..The objectives of this study were to compare the accuracy of ABO grouping, Rh typing, and antibody screening of blood samples collected in plastic tubes with that in glass tubes ..
  97. doi Hemolytic anemia after ABO nonidentical living donor kidney transplantation
    Mohamed A Bakr
    Urology and Nephrology Center, Mansoura University, Mansoura, Egypt
    Clin Exp Nephrol 13:161-5. 2009
    b>ABO compatible non-identical kidney transplants are used frequently. Acquired hemolytic anemia has been reported after ABO mismatched transplantation...
  98. ncbi Cell death with atypical features induced by the novel antitumoral drug CHS 828, in human U-937 GTB cells
    P Martinsson
    Department of Medical Sciences, Clinical Pharmacology, University Hospital, Uppsala University, SE 751 85 Uppsala, Sweden
    Eur J Pharmacol 417:181-7. 2001
    ..The characteristics of the cell death process were investigated in vitro in the apoptosis-prone cell line U-937 GTB. Mitochondria showed hyperpolarization at 24 to 32 h and a subsequent late disruption of mitochondria membrane ..
  99. ncbi Properties of Yersinia enterocolitica and Yersinia pseudotuberculosis in red blood cell concentrate of different ABO groups during 30-day storage at 4 degrees C
    P Orozova
    Institute of Microbiology, Department of Pathogenicity, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
    Clin Microbiol Infect 7:358-61. 2001
    ..The present study aimed to investigate the psychrophilic properties of Yersinia enterocolitica and Yersinia pseudotuberculosis as contaminants of donated blood...
  100. ncbi ABO, Lewis, secretor and non-secretor phenotypes in patients infected or uninfected by the Helicobacter pylori bacillus
    Luiz Carlos de Mattos
    Department of Molecular Biology, Faculty of Medicine of São José do Rio Preto, Brazil
    Sao Paulo Med J 120:55-8. 2002
    ..has been established as the main etiological factor in this disease, controversies about the associations of the ABO and Lewis blood group phenotypes and secretor and non-secretor phenotypes in relation to susceptibility towards ..

Research Grants63

  1. ABO ANTIBODIES--PARADIGM FOR HUMAN REPERTOIRE EVOLUTION
    TYLIS CHANG; Fiscal Year: 2000
    ..The immune response to the human ABO blood group system is ubiquitous and is the most important determinant in Transfusion Medicine and allogeneic ..
  2. Improvement in Paired Donation Program
    Stanislaw M Stepkowski; Fiscal Year: 2013
    ..makes possible the transplantation of kidneys from living donors who otherwise are not transplanted because of ABO blood group incompatibility and/or the presence of donor-specific antibodies (Abs;DSA) in sensitized patients...
  3. SUPPLY, EVALUATION AND SELECTION OF LIVING RENAL DONORS
    Akinlolu Ojo; Fiscal Year: 2001
    ..1) demographics, cultural beliefs and socioeconomic characteristics; (2) medical diagnoses and serologies; and (3) ABO blood groups and positive crossmatch...
  4. BABAK JOHN ORANDI; Fiscal Year: 2014
    ..per year in need of a kidney transplant are predicted to find a healthy, willing live donor with whom they are ABO or HLA incompatible...
  5. Donna M Woods; Fiscal Year: 2014
    ..In the field of transplantation, new protocols such as those used to confirm ABO compatibility between the donor and recipient have been highly effective...
  6. Martin S Zand; Fiscal Year: 2016
    ..DSA are directed at MHC antigens (alloantibody), tissue antigens, or ABO blood group carbohydrates...
  7. Development of a National Incompatible Kidney Transplant Registry
    Robert A Montgomery; Fiscal Year: 2010
    ..willing live donor but are relegated to forego the benefits of live donor renal transplantation because they are ABO or HLA incompatible with their donor...
  8. Dorry L Segev; Fiscal Year: 2016
    ..transplant find a live donor but are relegated to forego the benefits of live donor transplantation because of ABO or HLA incompatibilities...
  9. Axial Flow Effects in Proximal Tubule
    TONG WANG WANG; Fiscal Year: 2012
    ..These studies will provide new information on mechanisms of glomerulotubular balance (GTB) and aspects of renal fluid and HCO3- transport in physiological and pathophysiological conditions...
  10. Modulation of Outer Membrane Protein Expressin in Helicobacter pylori
    Jay V Solnick; Fiscal Year: 2012
    ..epithelium is mediated by a large family of outer membrane proteins (OMPs), the best studied of which is BabA, the ABO blood group binding adhesin...
  11. Jun Li; Fiscal Year: 2015
    ..known common variants, confirmed in recent genome-wide association studies (GWAS), such as Factor V Leiden and the ABO blood group, account for only half of this risk...
  12. Therapeutic Use of Heme Analogs: Absorption in Intestine
    David Stevenson; Fiscal Year: 2009
    ..Hyperbilirubinemia is exacerbated by hemolytic diseases, such as Rhesus isoimmunization and ABO incompatibility, which result in increased bilirubin production, as well as diseases that result in decreased ..
  13. Cohort Study of Biochemical and Genetic Risk Factors for Pancreatic Cancer
    BRIAN MATTHEW WOLPIN; Fiscal Year: 2013
    ..For Aim 3, I will expand on recent observations linking heterogeneity at the ABO blood group locus with plasma inflammatory markers and the risk of pancreatic cancer...
  14. Role of H. pylori Outer Membrane Proteins in Colonization and Host Response
    Jay V Solnick; Fiscal Year: 2013
    ..mediated by a large family of outer membrane proteins (OMPs), the best studied of which is BabA, the Lewis b (Leb)/ABO blood group binding adhesin...
  15. Chromium Mesoporphyrin in the Prevention of Neonatal Jaundice
    David K Stevenson; Fiscal Year: 2010
    ..Hyperbilirubinemia is exacerbated by hemolytic diseases, such as Rhesus isoimmunization and ABO incompatibility, which result in increased bilirubin production, as well as diseases that result in decreased ..
  16. Susan J Fisher; Fiscal Year: 2015
    ..g., ABO and Lewis families) and sulfate substituents...
  17. Transfusion-associated immune hemolysis
    Karina Yazdanbakhsh; Fiscal Year: 2010
    ..However, even the most immunogenic non-ABO antigen, RhD, alloimmunization rates do not reach 100%...
  18. Innate immunity in clinical islet transplantation: a clinical study (CIT0-01) in
    Olle Korsgren; Fiscal Year: 2012
    ..of reports that an injurious thrombotic/ inflammatory reaction is elicited when islets come in direct contact with ABO-compatible blood...
  19. Muredach P Reilly; Fiscal Year: 2014
    ..genome wide association studies (GWAS) is the consistent and diverse genome- wide significant associations of the ABO glycotransferase locus with heart and blood phenotypes...
  20. Muredach P Reilly; Fiscal Year: 2016
    ..SORT1, a novel LDL-cholesterol and myocardial infarction locus, in regulation of hepatocyte lipoproteins and, (b) ABO, a locus for risk endothelial risk biomarkers and myocardial infarction, in regulation of endothelial secreted ..
  21. Alison P Klein; Fiscal Year: 2016
    ..These studies have identified four promising regions involved in pancreatic cancer susceptibility: ABO rs505922 (P=4.3.10-6), two correlated SNPs on chromosome 13q22.1, rs9543325 (P=3.3.10-11) and rs9564966 (P=5.9...
  22. Kent R Bailey; Fiscal Year: 2016
    ..2 to determine "when genetic testing is appropriate" by 2a) testing Factor V Leiden, Prothrombin G20210A, and novel ABO SNPs as risk factors for VTE after hospitalization for major surgery and acute medical illness, and 2b) developing ..
  23. Natural Variation in VWF and FVIII
    JILL MARIE JOHNSEN; Fiscal Year: 2013
    ..The known VWF modifiers ABO blood group and gender will be assessed and accounted for in the analysis...
  24. Effect of Obesity on Long-Term Clinical Outcomes after Kidney Donation
    ANDREW MARK POSSELT; Fiscal Year: 2010
    ..this period who passed an initial medical screening evaluation but did not donate because they were found to be ABO- or crossmatch incompatible...
  25. Geographic modeling of very low birth weights around and near Texas federal super
    James A Thompson; Fiscal Year: 2010
    ..The study will evaluate the extent for which VLBW belongs in a broader cluster of adverse birth outcomes (ABO) and will identify high-risk locations and any spatial patterns of race-to-race variability...
  26. The Transfusion Chip: A Simple, Low Cost Microarray for DNA Based Blood Typing
    Michael E Hogan; Fiscal Year: 2011
    ..In spite of that new genetic sophistication, traditional blood group typing [ABO, Rh] is still performed, for the most part, via variations upon 80-year-old agglutination testing...
  27. Michael E Hogan; Fiscal Year: 2014
    ..I milestones: we have developed and optimized 22 PCR reactions, comprising the entire 7 gene blood group gene set [ABO, Rh, Duffy, Kidd, Kell, Dombrock &MNS];we have fabricated a Transfusion-Chip microarray prototype capable of ..
  28. Translation, Editing and Annotation of Ludwik Hirszfeld, The Story of One Life
    William Schneider; Fiscal Year: 2005
    ..stems primarily from the scientific accomplishments of Hirszfeld, who along with Emil von Dungern, established the ABO nomenclature and the inheritance of the blood groups, then discovered the population genetics of human blood groups...
  29. METASTASIS SPECIFIC CARBOHYDRATE ANTIGENS
    Reuben Lotan; Fiscal Year: 1991
    ..Among other carbohydrate antigens related to ABO/Le blood group, a decrease in Ulex europeus agglutinin-I reactive mucin (presumably type 2 blood group H and LeY ..
  30. Mechanisms of Immunomodulation by anti-RBC antibodies
    JAMES ZIMRING; Fiscal Year: 2009
    ..Although blood is matched for ABO and RhD antigens, there are several hundred additional blood group antigens against which transfusion recipients ..
  31. 2009 Stress Proteins in Growth, Development, and Disease Gordon Research Conferen
    JEFFREY BRODSKY; Fiscal Year: 2009
    ..for this meeting is Jeffrey Brodsky (University of Pittsburgh, Pittsburgh, PA) and the Vice-Chair is Lea Sistonen (Abo Akademi University, Turku, Finland)...
  32. BLOOD GROUP ANTIGENS AND ANTIBODIES
    JAMES MOHN; Fiscal Year: 1980
    ..Heavy emphasis will be placed on ABO and related blood group systems, such as Lewis and I, and P...
  33. RBC typing antibodies labeled with rare earth phosphor upconverting nanocrystals
    Joseph Friedberg; Fiscal Year: 2009
    ..At present, pre-transfusion blood typing involves only the major antigens of the ABO and Rh groups, and relies on the use of a largely- manual hemagglutination reaction...
  34. Norwalk-like Viruses and Their Receptors
    Xi Jiang; Fiscal Year: 2009
    ..Extended studies showed that different NLVs recognize different receptors defined by secretor, Lewis, and ABO types...
  35. IN VITRO INACTIVATION OF VIRUSES IN BLOOD COMPONENTS
    Daniel Meruelo; Fiscal Year: 1999
    ..clinically significant parameters of red cell surface membrane integrity, (2,3-DPG, hemolysis, normal expression of ABO, Rh, minor blood group antigens and possible deposition of IgG or complement on RBC), by treatment with HY will be ..
  36. T AND B CELL TOLERANCE IN HUMAN MIXED CHIMERAS
    Megan Sykes; Fiscal Year: 2003
    ..Several of these transplants have included major and minor ABO mismatches...
  37. LSIT
    Chella David; Fiscal Year: 2001
    ..the potential role of class I versus class II molecules in this disease process by using a class II knock-out (Abo) gene...
  38. T and B Cell Tolerance via Marrow Transplantation
    Megan Sykes; Fiscal Year: 2003
    ..by induction of mixed chimerism has important implications for the ability to perform cardiac allografts across ABO blood group barriers and in presensitized recipients, and for the extension of the mixed chimerism approach to ..
  39. TRANSFUSION OF ANTIGENICALLY MODIFIED ERYTHROCYTES
    Mark Scott; Fiscal Year: 2001
    ..In most acute injuries, simple RBC typing (ABO/Rh) is sufficient to identify appropriate donors...
  40. ANTIVASCULAR ENDOTHELIAL ANTIBODY--ORGAN TRANSPLANTATION
    G Cerilli; Fiscal Year: 1992
    ..that such sensitization is directed towards lymphocyte "specific" antigens and not transplant relevant (HLA, VEC, ABO) antigens; B) AVOID TRANSPLANTING PATIENTS WHO ARE SENSITIZED TO DONOR VEC ANTIGENS IN THE ABSENCE OF SENSITIZATION ..
  41. GLYCOLIPIDS--CELL INTERACTION/PROLIFERATION/ONCOGENESIS
    Senitiroh Hakomori; Fiscal Year: 1999
    ..Since we have cloned the A and B genes, in-depth understanding of the molecular genetic basis of aberrant ABO status in human cancer is another specific goal of this proposal.
  42. Identify Abeta Oligomer Inhibitors By Combinatorial Chemistry
    Lee Way Jin; Fiscal Year: 2009
    ..Recently, small molecule compounds that neutralize the neurotoxic effect of Ab oligomers (AbO) have shown promises in several studies...
  43. MEDICAL DEVICE TO REMOVE ANTI-A AND ANTI-B ANTIBODIES
    TERRY SCHAACK; Fiscal Year: 2001
    ..removes anti-A and anti-B antibodies may significantly increase organ availability by reducing or eliminating ABO matching requirements. There are no FDA-approved devices which achieve this goal...
  44. Maternal/fetal genotype incompatibility in schizophrenia
    Janet Sinsheimer; Fiscal Year: 2003
    ..The study will accomplish: (1) genotyping of plausible incompatibility loci (i.e., HLA, ABO, RHD) in samples with existing genotyping for putative schizophrenia susceptibility loci; (2) development of a ..
  45. Design of Extracorporeal Specific Antibody Filters
    William Federspiel; Fiscal Year: 2006
    ..Recipient anti-A represents the most clinically significant impediment to ABO-incompatible transplantation...
  46. GENETIC MAPPING IN BABOONS
    Jean MacCluer; Fiscal Year: 1993
    ..chromosome, for example transferrin (TF, human chromosome 3q), Gc and albumin (Gc and ALB, human chromosome 4q), ABO (human chromosome 9q), catalase (CAT, human chromosome 11p), peptidase E (PEPE, human chromosome 17q), and ..
  47. NOVEL DEVICES FOR RAPID BLOOD COMPATIBILITY TESTING
    John Roback; Fiscal Year: 2001
    ..in the laboratory of the PI to compare optimized DFS/MCD-minidiscs with currently marketed testing devices for ABO/Rh(D) typing, antibody screens, and crossmatching...
  48. MECHANISMS OF R RAS CELL ADHESION SIGNALING
    Andrew Chan; Fiscal Year: 2002
    ..This application aims to study the mechanisms involved in alterations in cell adhesion induced by ras related GTB binding protein R-ras...
  49. BLOOD CELL TYPING USING OPTICAL PHASE AND FLOW CYTOMETRY
    Douglas Burger; Fiscal Year: 1991
    ..notoriously labor intensive area of the clinical laboratory, manufacturers have concentrated on developing various ABO/Rh typing techniques...
  50. NEWBORN GENETIC SCREENING:FOR WHOSE BENEFIT?
    Lainie Ross; Fiscal Year: 2005
    ..OUTCOMES: The major outcomes will be a series of peer-reviewed articles and a full-length book entitled Newborn Genetic Screening: In whose Interest? For whose Benefit? ..
  51. DNA POLYMORPHISMS IN OVARIAN CANCER--CASE CONTROL STUDY
    Harvey Risch; Fiscal Year: 2002
    ..abstract_text> ..
  52. ICAM1 gene inactivation protects against ischemic injury
    Robert Montgomery; Fiscal Year: 2006
    ..This work has important implications for the selective inactivation of gene function in allografts through ex vivo gene transfer. ..
  53. INCREASE/gp120 IMMUNOGENICITY/LINKED ALPHA-GAL EPITOPES
    Uri Galili; Fiscal Year: 2005
    ..We will then also collaborate with a group studying immune responses in monkeys to determine the efficacy of this vaccine in a primate model. ..
  54. Epigenetic Alterations in Homeotic Genes
    Fumiichiro Yamamoto; Fiscal Year: 2005
    ..Both the constitutive and inducible expression systems will be used to examine the tumor suppressor function of these homeotic genes. ..
  55. Xenograft-like rejection of tumors in a-gal glycolipids
    URI GALILI GALILI; Fiscal Year: 2010
    ..We will study this treatment in a unique mouse model that simulates the pertinent human immunological parameters. Success in the studies in the mouse model will enable us to apply this treatment to cancer patients. ..
  56. PREVENTING ANTI-GAL PRODUCTION AGAINST XENOGRAFTS
    Uri Galili; Fiscal Year: 2003
    ..Success in these studies will help in planning effective treatments for preventing anti-Gal response in primate xenografts recipients. | ..
  57. Array-based methylation analysis using anti-5mC antibody
    Fumiichiro Yamamoto; Fiscal Year: 2007
    ..We will evaluate the sensitivity, specificity, and reproducibility of the method, using BAG clone microarrays, DNA fragment microarrays, and oligonucleotide microarrays. [unreadable] [unreadable] [unreadable]..
  58. CASE CONTROL STUDY OF OVARIAN CANCER HORMONAL ETIOLOGY
    Harvey Risch; Fiscal Year: 2002
    ....
  59. NOVEL APPROACHES TO IMPROVE AND EXTEND PLATELET STORAGE
    Sherrill Slichter; Fiscal Year: 2001
    ....
  60. Development of an ABO Incompatibility Stop Device (AISD)
    Christopher Hillyer; Fiscal Year: 2008
    unreadable] DESCRIPTION (provided by applicant): This is a Phase 1 STTR application entitled "Development of an ABO Incompatibility Stop Device" (hereafter AISD) to prevent mistransfusion...
  61. Case-Control Study of Pancreas Cancer Etiologic Factors
    Harvey Risch; Fiscal Year: 2008
    ..The factors to be examined here have received little attention with respect to pancreas cancer, and the proposed study will evaluate them systematically in a vigorous, large-scale and integrated project. [unreadable] [unreadable]..
  62. NEONATAL BILIRUBIN NEUROTOXICITY AND P-GLYCOPROTEIN
    Jon Watchko; Fiscal Year: 2007
    ..abstract_text> ..