Gene Symbol: ABL2
Description: ABL proto-oncogene 2, non-receptor tyrosine kinase
Alias: ABLL, ARG, abelson-related gene protein, c-abl oncogene 2, non-receptor tyrosine kinase, tyrosine-protein kinase ARG, v-abl Abelson murine leukemia viral oncogene homolog 2
Species: human

Top Publications

  1. ncbi Use of beta-lactamase as a secreted reporter of promoter function in yeast
    C P Cartwright
    University of Massachusetts Medical School, Department of Molecular Genetics and Microbiology, Worcester 01655
    Yeast 10:497-508. 1994
  2. pmc β1 integrin regulates Arg to promote invadopodial maturation and matrix degradation
    Brian T Beaty
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, New York, NY 10461, USA
    Mol Biol Cell 24:1661-75, S1-11. 2013
  3. pmc c-Abl and Arg are activated in human primary melanomas, promote melanoma cell invasion via distinct pathways, and drive metastatic progression
    S S Ganguly
    Department of Molecular and Biomedical Pharmacology, University of Kentucky School of Medicine, Lexington, 40536, USA
    Oncogene 31:1804-16. 2012
  4. pmc Reciprocal regulation of Abl and receptor tyrosine kinases
    Divyamani Srinivasan
    Department of Molecular and Biomedical Pharmacology, University of Kentucky School of Medicine, 800 Rose Street, Lexington, KY 40346, USA
    Cell Signal 21:1143-50. 2009
  5. pmc An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion
    Christopher C Mader
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA
    Cancer Res 71:1730-41. 2011
  6. doi c-Abl and Arg tyrosine kinases regulate lysosomal degradation of the oncoprotein Galectin-3
    X Li
    Beijing Institute of Biotechnology, Beijing, China
    Cell Death Differ 17:1277-87. 2010
  7. ncbi Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases
    Cheng Cao
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:39609-14. 2003
  8. pmc Two distinct phosphorylation pathways have additive effects on Abl family kinase activation
    Keith Q Tanis
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
    Mol Cell Biol 23:3884-96. 2003
  9. ncbi The Abl family kinases: mechanisms of regulation and signaling
    Ann Marie Pendergast
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Adv Cancer Res 85:51-100. 2002
  10. ncbi The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress
    C Cao
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:11465-8. 2001

Detail Information

Publications458 found, 100 shown here

  1. ncbi Use of beta-lactamase as a secreted reporter of promoter function in yeast
    C P Cartwright
    University of Massachusetts Medical School, Department of Molecular Genetics and Microbiology, Worcester 01655
    Yeast 10:497-508. 1994
    ..P, a 67 residue 'processing' segment with three sites for N-glycosylation, terminates in a Lys Arg site for cleavage by the Kex2 protease...
  2. pmc β1 integrin regulates Arg to promote invadopodial maturation and matrix degradation
    Brian T Beaty
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, New York, NY 10461, USA
    Mol Biol Cell 24:1661-75, S1-11. 2013
    ..Furthermore, β1 integrin interacts with the tyrosine kinase Arg and stimulates Arg-dependent phosphorylation of cortactin on tyrosine 421...
  3. pmc c-Abl and Arg are activated in human primary melanomas, promote melanoma cell invasion via distinct pathways, and drive metastatic progression
    S S Ganguly
    Department of Molecular and Biomedical Pharmacology, University of Kentucky School of Medicine, Lexington, 40536, USA
    Oncogene 31:1804-16. 2012
    ..Here, we found a previously unrecognized role for c-Abl and Arg in melanoma progression...
  4. pmc Reciprocal regulation of Abl and receptor tyrosine kinases
    Divyamani Srinivasan
    Department of Molecular and Biomedical Pharmacology, University of Kentucky School of Medicine, 800 Rose Street, Lexington, KY 40346, USA
    Cell Signal 21:1143-50. 2009
    Previously, we showed that Abl kinases (c-Abl, Arg) are activated downstream of PDGF in a manner dependent on Src kinases and PLC-gamma1, and promote PDGF-mediated proliferation and migration of fibroblasts...
  5. pmc An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion
    Christopher C Mader
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA
    Cancer Res 71:1730-41. 2011
    ..In this study, we provide evidence that the Abl-related nonreceptor tyrosine kinase Arg mediates epidermal growth factor (EGF)-induced cortactin phosphorylation, triggering actin polymerization in ..
  6. doi c-Abl and Arg tyrosine kinases regulate lysosomal degradation of the oncoprotein Galectin-3
    X Li
    Beijing Institute of Biotechnology, Beijing, China
    Cell Death Differ 17:1277-87. 2010
    ..This study shows that c-Abl and Abl-related gene (Arg) associate with and phosphorylate Gal3...
  7. ncbi Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases
    Cheng Cao
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:39609-14. 2003
    The c-Abl and Arg tyrosine kinases are activated in the cellular response to oxidative stress...
  8. pmc Two distinct phosphorylation pathways have additive effects on Abl family kinase activation
    Keith Q Tanis
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
    Mol Cell Biol 23:3884-96. 2003
    The activities of the related Abl and Arg nonreceptor tyrosine kinases are kept under tight control in cells, but exposure to several different stimuli results in a two- to fivefold stimulation of kinase activity...
  9. ncbi The Abl family kinases: mechanisms of regulation and signaling
    Ann Marie Pendergast
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Adv Cancer Res 85:51-100. 2002
  10. ncbi The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress
    C Cao
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:11465-8. 2001
    The Abl family of mammalian nonreceptor tyrosine kinases consists of c-Abl and ARG (Abl-related gene). Certain insights are available regarding the involvement c-Abl in the response of cells to stress...
  11. ncbi Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII
    Akira Endo
    Department of Structural Analysis, National Cardiovascular Center Research Institute, Suita, Osaka 565 8565, Japan
    J Biol Chem 277:23747-54. 2002
  12. ncbi A new ETV6/TEL partner gene, ARG (ABL-related gene or ABL2), identified in an AML-M3 cell line with a t(1;12)(q25;p13) translocation
    Y Iijima
    Division of Molecular Cytogenetics, Department of Clinical Pathology, Research Institute, International Medical Center of Japan, Tokyo, Japan
    Blood 95:2126-31. 2000
    ..We identified a novel ETV6 partner gene, ARG (ABL-related gene or ABL2), another TK gene in a cell line established from a patient with acute myelogenous leukemia (AML-M3) with a t(15;17)..
  13. ncbi Comparative tyrosine-kinase profiles in colorectal cancers: enhanced arg expression in carcinoma as compared with adenoma and normal mucosa
    W S Chen
    Division of Colorectal Surgery, Department of Surgery, Veterans General Hospital, Taipei, Taiwan, Republic of China
    Int J Cancer 83:579-84. 1999
    ..kinases expressed in these tissues: they include 10 non-receptor tyrosine kinases (yes, fyn, lyn, brk, abl, arg, jak1, jak3, tyk2 and itk), 17 receptor tyrosine kinases (erbB2, PDGF-Ralpha, PDGF-Rbeta, kit, c-fms, met, ron, FGF-..
  14. ncbi ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks
    B Wang
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 272:17542-50. 1997
    b>Arg and c-Abl represent the mammalian members of the Abelson family of protein-tyrosine kinases. A novel Arg/Abl-binding protein, ArgBP2, was isolated using a segment of the Arg COOH-terminal domain as bait in the yeast two-hybrid system...
  15. ncbi EG-1 interacts with c-Src and activates its signaling pathway
    Ming Lu
    Department of Surgery, Division of Oncology, UCLA School of Medicine, Los Angeles, CA, USA
    Int J Oncol 29:1013-8. 2006
    ..Furthermore, EG-1 shows interaction with multiple other SH3- and WW-containing molecules involved in various signaling pathways. These observations suggest that EG-1 may be involved in signaling pathways including c-Src activation...
  16. ncbi The tyrosine kinase abl-related gene ARG is fused to ETV6 in an AML-M4Eo patient with a t(1;12)(q25;p13): molecular cloning of both reciprocal transcripts
    G Cazzaniga
    Clinica Pediatrica Università di Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    Blood 94:4370-3. 1999
    ..reaction (3'RACE-PCR), a novel fusion transcript was identified between the ETV6 and the Abelson-related gene (ARG) at 1q25, resulting in a chimeric protein consisting of the HLH oligomerization domain of ETV6 and the SH2, SH3, ..
  17. pmc Mediation by bradykinin of rat paw oedema induced by collagenase from Clostridium histolyticum
    F J Legat
    Department of Experimental and Clinical Pharmacology, University of Graz, Austria
    Br J Pharmacol 112:453-60. 1994
    ..Heat-inactivated collagenase was ineffective. 3. The B2 bradykinin (BK) antagonist icatibant (D-Arg-[Hyp3-Thi5-D-Tic7- Oic8] bradykinin, formerly named Hoe-140) reduced oedema formation in a dose-dependent manner ..
  18. pmc Bradykinin-induced activation of nociceptors: receptor and mechanistic studies on the neonatal rat spinal cord-tail preparation in vitro
    A Dray
    Sandoz Institute for Medical Research, London
    Br J Pharmacol 107:1129-34. 1992
    ..The rank order potency was Hoe 140> LysLys [Hyp3,Thi5 8,D-Phe7]-bradykinin> D-Arg[Hyp3, Thi5'8, D-Phe7]-bradykinin = D-Arg[Hyp2,Thi5'8, D-Phe7]-bradykinin.7...
  19. pmc Bradykinin-stimulated phosphoinositide metabolism in cultured canine tracheal smooth muscle cells
    C M Yang
    Department of Pharmacology, Chang Gung Medical College, Kwei San, Tao Yuan, Taiwan
    Br J Pharmacol 111:21-8. 1994
    ..3 +/- 0.7 nM, (n = 5), respectively. 2. D-Arg[Hyp3, D-Phe7]-BK and D-Arg[Hyp3, Thi5,8, D-Phe7]-BK, B2 receptor antagonists, were equipotent in blocking the BK-..
  20. pmc Ca(2+)-dependent and -independent mechanism of cyclic-AMP reduction: mediation by bradykinin B2 receptors
    H Sipma
    Groningen Institute for Drugs Studies GIDS, Department of Clinical Pharmacology, University of Groningen, The Netherlands
    Br J Pharmacol 115:937-44. 1995
    ..cyclic AMP formation in isoprenaline prestimulated cells, while the bradykinin B2 receptor antagonists, Hoe 140 (D-Arg[Hyp3, Thi5, D-Tic7, Oic8]-BK) and D-Arg[Hyp3, Thi5,8, D-Phe7]-BK completely abolished the bradykinin response in ..
  21. ncbi Screening for mutations in the steroidogenic acute regulatory protein and steroidogenic factor-1 genes, and in CYP11A and dosage-sensitive sex reversal-adrenal hypoplasia gene on the X chromosome, gene-1 (DAX-1), in hyperandrogenic hirsute women
    R M Calvo
    Department of Endocrinology, , Madrid 28034, Spain
    J Clin Endocrinol Metab 86:1746-9. 2001
    ..Two variants were identified in the SF-1 gene. A G-->C change in exon 6, resulting in an Arg(365)Pro mutation, was found in 1 of 45 patients, but not in controls...
  22. pmc Mechanism of bradykinin-induced plasma extravasation in the rat knee joint
    H Cambridge
    Pharmacology Group, King s College London
    Br J Pharmacol 115:641-7. 1995
    ..into the knee which was inhibited by co-perfusion of the selective bradykinin B2 receptor antagonist D-Arg-[Hyp3,Thi5,D-Tic7,Oic8]-bradykinin (Hoe 140, 200 nM). 3...
  23. pmc Bradykinin B1 receptors in the rabbit urinary bladder: induction of responses, smooth muscle contraction, and phosphatidylinositol hydrolysis
    S K Butt
    Biomedical Sciences Division, King s College London, Chelsea
    Br J Pharmacol 114:612-7. 1995
    ..in the bladder were competitively antagonized by the B1 receptor-selective antagonists [Leu8,des-Arg9]-BK and D-Arg-[Hyp3,Thi5,D-Tic7,Oic8,des-Arg9]-BK ([des-Arg10]-Hoe140) (pKB estimates were 6.1 +/- 0.1 and 7.1 +/- 0...
  24. ncbi [Presence of a specific binding site of endothelin on cultured smooth muscle cells]
    P Roubert
    Institut Henri-Beaufour, Les Ulis, France
    Arch Mal Coeur Vaiss 82:1261-3. 1989
    ..2 nM, whereas an absence of competition was observed with 1 microM of vasoactive substances such as angiotensin II, arg-vasopressin, atrial natriuretic factor, histamine, epinephrine and norepinephrine, and with the calcium entry ..
  25. ncbi The long acting human insulin analog HOE 901: characteristics of insulin signalling in comparison to Asp(B10) and regular insulin
    L Berti
    Abteilung IV, Medizinische Klinik und Poliklinik, , Germany
    Horm Metab Res 30:123-9. 1998
    HOE 901 is a new biosynthetic long-acting human insulin analog (GLY[A21]ARG[B31]ARG[B32])...
  26. pmc Bradykinin B2 receptors and coupling mechanisms in the smooth muscle of the guinea-pig taenia caeci
    J L Field
    Biomedical Sciences Division, King s College London, Chelsea, London
    Br J Pharmacol 113:607-13. 1994
    ..The B2 receptor-selective antagonist, D-Arg-[Hyp3,Thi5,D-Tic7,Oic8]-BK (Hoe 140) (30-300 nM), inhibited both the bradykinin-induced relaxation and contraction ..
  27. ncbi New family of glutathionyl-biomimetic ligands for affinity chromatography of glutathione-recognising enzymes
    S C Melissis
    Department of Agricultural Biotechnology, Agricultural University of Athens, Greece
    J Chromatogr A 917:29-42. 2001
    ..biomimetic moiety is primarily achieved by the strong ionic interactions with the Zn2+ ion of FaDH and Arg 114, and by the hydrophobic contacts made with Tyr 92 and Met 140...
  28. ncbi [Biogenesis of peroxisome--targeting signal and peroxisome assembly factor]
    Y Fujiki
    Meiji Institute of Health Science, Kanagawa
    No To Hattatsu 24:181-5. 1992
    ..Further experiments have strongly suggested that the SKL motif, Ser/Ala-Lys/Arg/His-Leu-COOH commonly found at C-termini of many peroxisomal proteins, functions as a peroxisome-targeting signal...
  29. pmc Role of platelet-activating factor (PAF) in platelet accumulation in rabbit skin: effect of the novel long-acting PAF antagonist, UK-74,505
    F Pons
    Department of Applied Pharmacology, National Heart and Lung Institute, London
    Br J Pharmacol 109:234-42. 1993
    ..BK), histamine, formyl-methionyl-leucylphenylalanine (FMLP), zymosan-activated plasma (ZAP, as a source of C5a des Arg), leukotriene B4 (LTB4) or interleukin-8 (IL-8). 4. UK-74,505, administered i.v...
  30. ncbi Plasmodium falciparum in Kenya: high prevalence of drug-resistance-associated polymorphisms in hospital admissions with severe malaria in an epidemic area
    S A Omar
    Centre for Biotechnology Research Development, Kenya Medical Research Institute, P O Box 54840, Mbagathi Road, Nairobi, Kenya
    Ann Trop Med Parasitol 95:661-9. 2001
    ..samples also had the mutations associated with resistance to pyrimethamine and sulfadoxine: (Asn)51(Ile), (Cys)59(Arg) and (Ser)108(Asn) of gene dhfr (chromosome 4) and (Ala)437(Gly) and (Lys)540(Glu) of dhps (chromosome 8), ..
  31. ncbi Integration of the multiple controls regulating the expression of the arginase gene CAR1 of Saccharomyces cerevisiae in response to differentnitrogen signals: role of Gln3p, ArgRp-Mcm1p, and Ume6p
    E Dubois
    Institut de Recherches du CERIA, , Brussels, Belgium
    Mol Gen Genet 253:568-80. 1997
    ..The UAS(arg), containing the previously defined "arginine boxes" is the region that responds to the inducer through the action ..
  32. pmc Support of renal blood flow after ischaemic-reperfusion injury by endogenous formation of nitric oxide and of cyclo-oxygenase vasodilator metabolites
    J P Cristol
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 109:188-94. 1993
    ..v., n = 4) significantly enhanced the rise in RVR associated with I/R injury. 4. Infusion of L-arginine (L-Arg; 1 or 3 mg kg-1 min-1, i.v., n = 5 and 4, respectively) or D-Arg (1 mg kg-1 min-1, i.v...
  33. pmc The kinin B1 receptor antagonist des-Arg9-[Leu8]bradykinin: an antagonist of the angiotensin AT1 receptor which also binds to the AT2 receptor
    D Pruneau
    Centre de Recherche, Laboratoires Fournier S C A, Daix, France
    Br J Pharmacol 114:115-8. 1995
    ..Values of Ki for des-Arg9-[Leu8]BK, des-Arg10-[Leu9]KD, des-Arg9-BK, des-Arg 10-KD and KD were 0.3 +/- 0.1, 0.7 +/- 0.1, 1.2 +/- 0.3, 1.5 +/- 0.3 and 7.0 +/- 1.6 microM, respectively. 6...
  34. ncbi Cloning and sequence analyses of cDNAs encoding vasotocin and isotocin precursors of chum salmon, Oncorhynchus keta: evolutionary relationships of neurohypophysial hormone precursors
    S Hyodo
    Laboratory of Physiology, University of Tokyo, Nakano
    J Comp Physiol B 160:601-8. 1991
    ..sIT precursors were found to contain a signal peptide and hormone that is connected to a neurophysin by a Gly-Lys-Arg sequence...
  35. pmc The use of synthetic analogues of Arg-Gly-Asp (RGD) and soluble receptor of tumor necrosis factor to prevent acute and chronic experimental liver injury
    R Bruck
    Department of Gastroenterology, E. Wolfson Medical Center, Holon, Israel
    Yale J Biol Med 70:391-402. 1997
    ..The target epitope of several such integrin receptors is the Arg-Gly-Asp (RGD) sequence, a cell adhesion motif shared by several matrix-associated adhesive glycoproteins...
  36. ncbi Liquid chromatographic determination of D- and L-amino acids by derivatization with o-phthaldialdehyde and N-isobutyryl-L-cysteine. Applications with reference to the analysis of peptidic antibiotics, toxins, drugs and pharmaceutically used amino acids
    H Bruckner
    Institute of Food Technology, University of Hohenheim, Stuttgart, Germany
    J Chromatogr A 711:201-15. 1995
    ..bacitracin, gramicidins A and S, polymyxin B, metanicin C, the peptide toxin malformin A and the peptide drugs D-Arg-[Hyp3,Thi5,8,D-Phe7]-bradykinin, beta-casomorphin and alpha s1-exorphin...
  37. pmc Effects of bradykinin receptor antagonists on antigen-induced respiratory distress, airway hyperresponsiveness and eosinophilia in guinea-pigs
    S G Farmer
    Nova Pharmaceutical Corporation, Baltimore, Maryland 21224
    Br J Pharmacol 107:653-9. 1992
    ..A B2 receptor antagonist, D-Arg-[Hyp3, Thi5,8,D-Phe7]-BK (NPC 349) had a small, but statistically significant inhibitory effect on responsiveness ..
  38. pmc NH2-terminal substitutions of basic amino acids induce translocation across the microsomal membrane and glycosylation of rabbit cytochrome P450IIC2
    E Szczesna-Skorupa
    Department of Physiology and Biophysics, University of Illinois, Urbana 61801
    J Cell Biol 108:1237-43. 1989
    Insertion of rabbit cytochrome P450IIC2 and its modified form, [2-lys,3-arg]P450IIC2, into microsomal membranes was studied in an in vitro transcription/translation/translocation system...
  39. pmc Differential effects of B2 receptor antagonists upon bradykinin-stimulated phospholipase C and D in guinea-pig cultured tracheal smooth muscle
    S Pyne
    Department of Physiology and Pharmacology, University of Strathclyde, Royal College, Glasgow
    Br J Pharmacol 110:477-81. 1993
    ..Bradykinin-stimulated (10 nM, EC40) Ins(1,4,5)P3 formation was inhibited by B2 receptor antagonists, D-Arg-[Hyp3,D-Phe7]-bradykinin (NPC 567) and D-Arg-[Hyp3,Thi5,8,D-Phe7]-bradykinin (NPC 349), with log IC50 values of -6...
  40. ncbi Sensitive determination of N-terminal prolyl peptides by high-performance liquid chromatography with laser-induced fluorescence detection
    M Ishibashi
    Division of Drugs, National Institute of Health Sciences, Tokyo, Japan
    J Chromatogr A 661:105-12. 1994
    ..hormone), Pro-Thr-Pro-Ser-NH2 (IgA1 proteinase inhibitor) and Pro-Asp-Val-Asp-His-Val- Phe-Leu-Arg-Phe-NH2 [FMRF amide-like (Phe-Met-Arg-Phe-NH2) neuropeptide], were well separated by reversed-phase HPLC with water-..
  41. pmc Cutaneous permeability responses to bradykinin and histamine in the guinea-pig: possible differences in their mechanism of action
    W Paul
    Department of Pharmacology, King s College, London
    Br J Pharmacol 111:159-64. 1994
    ..1 mumol/site) on the response to BK but not on that to histamine was significantly reversed by L-arginine (L-Arg; 10 mumol/site). D-arginine (D-Arg; 10 mumol/site) had no significant effect in either case. 5...
  42. ncbi [Chronic and acute effect of cycletanine in NO-dependent hypertensive pregnant rats]
    B Van Overloop
    CNRS URA 60, , , Illkirch-Graffenstaden
    Arch Mal Coeur Vaiss 88:1223-7. 1995
    ..enriched diet produced hypertension we measured in vivo cardiovascular responses to PGF2 alpha, L-arginine (L-arg) and cicletanine (Cic, IPSEN, France) which enhances PGI2 production...
  43. ncbi Nitric oxide in cyclosporine A-induced hypertension: role of protein kinase C
    G K Oriji
    Hypertension-Endocrine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Hypertens 12:1091-7. 1999
    ..The effects of CsA were reversed both in vivo and in vitro by pretreatment with L-arginine (L-Arg; 10 mg/kg/day intraperitoneally), the precursor of NO...
  44. ncbi [Homologous and heterologous regulations of endothelin receptors on smooth muscle cells]
    P Roubert
    Institut Henri-Beaufour, Les Ulis, France
    Arch Mal Coeur Vaiss 83:1183-5. 1990
    ..On the same conditions, Arg-vasopressin (1 microM) was able to down-regulate ET-1 receptors by less than 30 p...
  45. ncbi Glutamate 83 is important for stabilization of domain-domain conformation of Thermus aquaticus glycerol kinase
    H S Huang
    School of Pharmaceutical Sciences, Nagasaki University, Bunkyo-machi, Nagasaki 852-8521, Japan
    J Biochem 128:207-11. 2000
    ..Three residues (Arg-82, Glu-83, and Asp-244) of T...
  46. ncbi Rat tripeptidyl peptidase I: molecular cloning, functional expression, tissue localization and enzymatic characterization
    P G Du
    Department of Medical Biochemistry, Shiga University of Medical Science, Seta, Otsu, Japan
    Biol Chem 382:1715-25. 2001
    ..TPP I released the tripeptide Arg-Val-Tyr from angiotensin III more rapidly than from Ala-Ala-Phe-MCA, and also released Gly-Asn-Leu from neuromedin ..
  47. ncbi Release of proteins and polysaccharides from the albumen gland of the freshwater snail Helisoma duryi: effect of cAMP and brain extracts
    F Morishita
    Zoological Institute, Faculty of Science, Hiroshima University, Higashi, Japan
    J Comp Physiol A 182:817-25. 1998
    ..The neuroactive agents serotonin, Phe-Met-Arg-Phe-amide, Tyr-Gly-Gly-Phe-Met-Arg-Phe-amide, small cardioactive peptide B, and caudodorsal cell hormone were also ..
  48. ncbi [Response of the coronary arteries to cold test and flow velocity increase is improved by deferoxamine but not by L-arginine in diabetic patients]
    A Nitenberg
    Service de Physiologie et d'Explorations Fonctionnelles, INSERM U 426, , Colombes
    Arch Mal Coeur Vaiss 90:1037-41. 1997
    ..v. L-arginine (L-arg, 625 mg/min x 10 min) or i.v...
  49. ncbi Blunted GH response to growth hormone-releasing hormone (GHRH) alone or combined with arginine in non-insulin-dependent diabetes mellitus
    V Martina
    Dipartimento di Fisiopatologia Clinica, , Italy
    Horm Metab Res 27:26-30. 1995
    ..OD), we investigated the somatotrope responsiveness to GHRH (1 microgram/kg) alone or combined with arginine (ARG, 0...
  50. ncbi Enhanced sensitivity for peptide mapping with electrospray liquid chromatography-mass spectrometry in the presence of signal suppression due to trifluoroacetic acid-containing mobile phases
    A Apffel
    Bay Analytical Operation, Hewlett-Packard Co, Palo Alto, CA 94304, USA
    J Chromatogr A 712:177-90. 1995
    ..A third application demonstrates the identification of glycosylation sites in an endoproteinase Arg C digest of single-chain plasminogen activator through the use of in-source collisionally induced dissociation.
  51. pmc Differential effects of the PAF receptor antagonist UK-74,505 on neutrophil and eosinophil accumulation in guinea-pig skin
    M J Sanz
    Department of Applied Pharmacology, National Heart and Lung Institute, London
    Br J Pharmacol 113:513-21. 1994
    ..on responses elicited by leukotriene B4 (LTB4) and zymosan-activated plasma (ZAP, used as a source of C5a des Arg). UK-74,505 (2...
  52. pmc Clots of beta-fibrin. Viscoelastic properties, temperature dependence of elasticity, and interaction with fibrinogen-binding tetrapeptides
    A Shimizu
    Department of Chemistry, University of Wisconsin, Madison 53706
    Biophys J 53:311-8. 1988
    ..Introduction (by diffusion) of the tetrapeptides Gly-His-Arg-Pro (GHRP) and Gly-Pro-Arg-Pro (GPRP), which resemble the B and A binding sites on the E domain of fibrin ..
  53. ncbi Abnormal polymerization and normal binding of plasminogen and t-PA in three new dysfibrinogenaemias: Barcelona III and IV (gamma Arg 275-->His) and Villajoyosa (gamma Arg 275-->Cys)
    M Borrell
    , Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Blood Coagul Fibrinolysis 6:198-206. 1995
    ..The altered properties observed in fibrin monomers produced from fibrinogen with the gamma Arg 275-->His or gamma Arg 275-->Cys substitution, suggests that this amino acid is important in maintaining the ..
  54. ncbi A yeast protein that bidirectionally affects nucleocytoplasmic transport
    D R Singleton
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Cell Sci 108:265-72. 1995
    ..J. Cell Biol. 119, 737-747). NPL3 includes bipartite RNA recognition motifs (RRM) and a Gly-Arg repeat domain, as in several nucleolar proteins...
  55. ncbi Peptide chiral purity determination: hydrolysis in deuterated acid, derivatization with Marfey's reagent and analysis using high-performance liquid chromatography-electrospray ionization-mass spectrometry
    D R Goodlett
    Immunobiology Research Institute, Annandale, NJ 08801, USA
    J Chromatogr A 707:233-44. 1995
    ..This procedure was used to determine the chiral purity of each amino acid in a purified, hexapeptide by-product (Arg-Lys-Lys-Asp-Val-Tyr) present in a kilogram batch of the synthetic pentapeptide, thymopentin (Arg-Lys-Asp-Val-Tyr).
  56. pmc Characterization of beta-galactosidase mutations Asp332-->Asn and Arg148-->Ser, and a polymorphism, Ser532-->Gly, in a case of GM1 gangliosidosis
    S Zhang
    Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8
    Biochem J 348:621-32. 2000
    ..converts Asp(332) into asparagine, and both a mutation (C492-->A in exon 4, leading to the amino acid change of Arg(148)-->Ser) and a polymorphism (A1644-->G in exon 15, leading to a change of Ser(532)-->Gly) on the other ..
  57. ncbi Analysis of two mutated vacuolar proteins reveals a degradation pathway in the endoplasmic reticulum or a related compartment of yeast
    A Finger
    , , Germany
    Eur J Biochem 218:565-74. 1993
    ..Mutant CPY carries an Arg instead of a Gly residue in a highly conserved region, two positions distant from the active-site Ser...
  58. ncbi Melanocortins and cardiovascular regulation
    D H Versteeg
    Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Utrecht University, Netherlands
    Eur J Pharmacol 360:1-14. 1998
    ..of pro-opiomelanocortin-derived peptides that have the melanocyte-stimulating hormone (MSH) core sequence, His-Phe-Arg-Trp, in common. Melanocortins have been described as having a variety of cardiovascular effects...
  59. pmc A recombinant hybrid anaphylatoxin with dual C3a/C5a activity
    W Bautsch
    Institute of Medical Microbiology, Hanover Medical School, Germany
    Biochem J 288:261-6. 1992
    ..sequence of human C5a were exchanged to create the native C-terminal human C3a (hC3a) sequence Leu-Gly-Leu-Ala-Arg. This hybrid anaphylatoxin rC5a-(1-69)-LGLAR exhibited true C3a and C5a activity when tested in the guinea pig ..
  60. ncbi A kallikrein-like enzyme in human vascular tissue
    P Madeddu
    Clinica Medica, Sassari University, Italy
    Am J Hypertens 6:344-8. 1993
    ..for protein content and for active and total (trypsin activation) enzymatic activity on the peptide H-D-Val-Leu-Arg-paranitroanilide (S2266), a synthetic substrate for glandular kallikrein...
  61. ncbi Stability of o-phthalaldehyde-sulfite derivatives of amino acids and their methyl esters: electrochemical and chromatographic properties
    G Turiak
    Department of Pharmacology, Boston University School of Medicine, MA 02118
    J Chromatogr A 668:323-9. 1994
    ..detection was used to monitor the decomposition of five amino acid o-phthalaldehyde (OPA)-sulfite derivatives (Ala, Arg, Glu, Ser, Tyr) and their methyl ester derivatives as well...
  62. ncbi Substitutions at the P(1) position in BPTI strongly affect the association energy with serine proteinases
    A Grzesiak
    Protein Engineering Laboratory, Institute of Biochemistry and Molecular Biology, University of Wroclaw, Tamka 2, Wroclaw, 50-137, Poland
    J Mol Biol 301:205-17. 2000
    ..seven different mutants of bovine pancreatic trypsin inhibitor (BPTI); the mutants contain Gly, Ala, Ser, Val, Leu, Arg, and Trp at the P(1) position of the reactive site...
  63. pmc A ubiquitin mutant with specific defects in DNA repair and multiubiquitination
    J Spence
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115
    Mol Cell Biol 15:1265-73. 1995
    ..chains, we examined the effects of individually substituting each of six other Lys residues in ubiquitin with Arg. Substitution of Lys-63 resulted in the disappearance of a family of abundant multiubiquitin-protein conjugates...
  64. ncbi De novo design, synthesis, and pharmacology of alpha-melanocyte stimulating hormone analogues derived from somatostatin by a hybrid approach
    Guoxia Han
    Departments of Chemistry and Anatomy, University of Arizona, Tucson, Arizona 85721, USA
    J Med Chem 47:1514-26. 2004
    ..CTAP which binds specifically to micro opioid receptors, and the core pharmacophore of alpha-MSH (His-Phe-Arg-Trp)...
  65. pmc Characteristics of the bradykinin-induced changes in intracellular calcium ion concentration of single bovine tracheal smooth muscle cells
    K A Marsh
    Department of Physiology and Pharmacology, University of Nottingham Medical School, Queen s Medical Centre
    Br J Pharmacol 110:29-35. 1993
    ..7 M) in the presence of extracellular calcium ions (2 mM). The bradykinin B2 receptor antagonist, D-Arg[Hyp3,Thi5,8,D-Phe7]- bradykinin, produced a parallel shift to the right of the bradykinin concentration-response ..
  66. ncbi Total resolution of 17 DL-amino acids labelled with a fluorescent chiral reagent, R(-)-4-(3-isothiocyanatopyrrolidin-1-y1)-7-(N,N-dimethylaminosulfonyl)- 2,1,3-benzoxadiazole, by high-performance liquid chromatography
    D Jin
    Department of Analytical Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    J Chromatogr A 822:215-24. 1998
    ..Peak resolution was in the range of 0.92 (DL-Arg)-9.8 (DL-Cys)...
  67. pmc Differential effects of lumenal L-arginine and NG-nitro L-arginine on blood flow and water fluxes in rat ileum
    D Mailman
    Biology Department, University of Houston, TX 77204
    Br J Pharmacol 112:304-10. 1994
    ..NO) in the local regulation of H2O absorption and blood flow in rat ileum was studied by perfusing L-arginine (L-Arg) (0.1-1.0 mM) and NG-nitro L-arginine (L-NOARG) (0.01-1.0 mM) through the lumen...
  68. pmc Inhibitory actions of diphenyleneiodonium on endothelium-dependent vasodilatations in vitro and in vivo
    Y X Wang
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada
    Br J Pharmacol 110:1232-8. 1993
    ..relaxation was prevented by pretreatment with NADPH (5 x 10(-3) M) and FAD (5 x 10(-4) M) but not L-arginine (L-Arg, 2 x 10(-3) M)...
  69. ncbi Porin of Rhodobacter capsulatus: biochemical and functional characterization
    D Woitzik
    , Mikrobiologie, , Freiburg, Bundesrepublik Deutschland
    Z Naturforsch C 45:576-82. 1990
    ..0, was obtained on isoelectric focusing. Gas-phase sequencing of the 23 N-terminal residues revealed Glu-Val-Lys-Leu-Ser-Gly-Asp-Ala-Arg-Met-Gly-Val-Met-Tyr-Asn-Gly-Asp-Asp- X-Asn- Phe-Ser-Ser.
  70. ncbi A stretch of positively charged amino acids at the N terminus of Hansenula polymorpha Pex3p is involved in incorporation of the protein into the peroxisomal membrane
    R J Baerends
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands
    J Biol Chem 275:9986-95. 2000
    ..Here, we show that a conserved stretch of positively charged amino acids (Arg(11)-X-Lys-Lys-Lys(15)) in the N terminus of Hansenula polymorpha Pex3p is involved in incorporation of the protein ..
  71. ncbi Modulation by APGW-amide, an Achatina endogenous inhibitory tetrapeptide, of currents induced by neuroactive compounds on Achatina neurons: peptides
    X Y Han
    Department of Physiology, Gifu University School of Medicine, Japan
    Gen Pharmacol 29:531-8. 1997
    ..2. Outward current (Iout) caused by FMRFamide (Phe-Met-Arg-Phe-NH2) on v-RCDN, which was probably K+ dependent, was inhibited with membrane conductance (g) increase by APGW-..
  72. ncbi In the absence of endogenous mouse apolipoprotein E, apolipoprotein E*2(Arg-158 --> Cys) transgenic mice develop more severe hyperlipoproteinemia than apolipoprotein E*3-Leiden transgenic mice
    B J van Vlijmen
    TNO Prevention and Health, Gaubius Laboratory, 2301 CE Leiden, The Netherlands
    J Biol Chem 271:30595-602. 1996
    Apolipoprotein E*2(Arg-158 --> Cys) (APOE*2) transgenic mice were generated and compared to the previously generated apolipoprotein E*3-Leiden (APOE*3-Leiden) transgenic mice to study the variable expression of hyperlipoproteinemia ..
  73. ncbi Dietary L-arginine supplementation normalizes regional blood flow in Dahl-Iwai salt-sensitive rats
    H He
    Department of Pharmacology, Kagawa Medical School, Miki-cho, Kita-gun, Japan
    Am J Hypertens 10:89S-93S. 1997
    ..One group (S or R rats) was maintained on tap water and the other group (S/Arg) of S rats received tap water containing L-arginine at a concentration of 1.5%...
  74. ncbi Transition from argatroban to oral anticoagulation with phenprocoumon or acenocoumarol: effects on prothrombin time, activated partial thromboplastin time, and Ecarin Clotting Time
    Sebastian Harder
    Pharmazentrum Frankfurt, Institute for Clinical Pharmacology, University Hospital, Frankfurt am Main, Germany
    Thromb Haemost 91:1137-45. 2004
    Treatment with the direct thrombin inhibitor argatroban (ARG) is often followed by vitamin K-antagonist treatment (VKA). Phenprocoumon (PC) and acenocoumarol (AC) are frequently used in Europe...
  75. ncbi Processing of C-terminal lysine and arginine residues of proteins isolated from mammalian cell culture
    R J Harris
    Analytical Chemistry Department, Genentech, Inc, South San Francisco, CA 94080, USA
    J Chromatogr A 705:129-34. 1995
    C-terminal Lys or Arg residues whose presence was expected based on gene sequence information are often absent in proteins isolated from mammalian cell culture...
  76. ncbi An 18.3 kb DNA fragment from yeast chromosome VII carries four unknown open reading frames, the gene for an Asn synthase, remnants of Ty and three tRNA genes
    L van Dyck
    , , Louvain la Neuve, Belgium
    Yeast 13:171-6. 1997
    ..The segment also contains tRNA genes for Asn, Arg and Ile as well as sigma element and two solo deltas...
  77. ncbi Trp64Arg mutation of beta3-adrenergic receptor in essential hypertension: insulin resistance and the adrenergic system
    T Fujisawa
    Department of Geriatric Medicine, Osaka University Medical School, Japan
    Am J Hypertens 10:101-5. 1997
    ..The allele frequency of the mutation (Arg) in patients with essential hypertension was similar to that in control subjects (35 of 202 alleles [17...
  78. ncbi Involvement of mechanisms dependent on NMDA receptors, nitric oxide and protein kinase A in the hippocampus but not in the caudate nucleus in memory
    J Quevedo
    , Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Behav Pharmacol 8:713-7. 1997
    The effects of the NMDA receptor antagonist AP5, the nitric oxide synthase (NO) inhibitor NO-arg or the protein kinase A (PKA) inhibitor KT5720 on memory were evaluated...
  79. ncbi Selection and characterization of amino acid substitutions at residues 237-240 of TEM-1 beta-lactamase with altered substrate specificity for aztreonam and ceftazidime
    C Cantu
    Structural and Computational Biology and Molecular Biophysics Program, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 271:22538-45. 1996
    ..exhibited a Gly for Ala substitution at position 237, a Ser for Gly substitution at position 238, and a Lys/Arg for Glu at position 240...
  80. ncbi [Prognosis and evaluation of drug therapy by V3 and RT gene analysis of HIV-1]
    M Morimoto
    Osaka Prefectural Institute of Public Health, Japan
    Kansenshogaku Zasshi 70:347-53. 1996
    ..HIV-1 from a patient who had rapidly taken a turn for the worse had basic amino acid at position 11 (Arg) and lost an acidic amino acid at position 25 (Gln) of V3...
  81. pmc Differences in substrate and inhibitor sequence specificity of human, mouse and rat tissue kallikreins
    Sandro E Fogaça
    Department of Biophysics, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Rua Tres de Maio 100, São Paulo 04044 20, Brazil
    Biochem J 380:775-81. 2004
    ..Bradykinin was released from these peptides by the mK1- and rK1-mediated hydrolysis of Arg-Arg and Arg-Ser (or Arg-Ala) peptide bonds...
  82. ncbi Effects of L-arginine and furosemide on blood pressure and renal function in volume-expanded rats
    M A Costa
    Catedra de Fisiologia, Departamento de Ciencias Biologicas, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956, Capital Federal, Buenos Aires, Argentina
    Clin Exp Pharmacol Physiol 28:528-32. 2001
    1. The aim of the present study was to investigate the effects of L-arginine (L-Arg) on blood pressure and water and electrolyte excretion in control and extracellular fluid volume-expanded rats (10% bodyweight with 0...
  83. pmc Potentiation of the vasorelaxant activity of nitric oxide by hydroxyguanidine: implications for the nature of endothelium-derived relaxing factor
    A Zembowicz
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 107:1001-7. 1992
    ..These relaxations were inhibited by NG-nitro-L-arginine methyl ester (L-NAME, 10 microM) and L-arginine (L-Arg, 1 mM) reversed the inhibitory effects of L-NAME. 7...
  84. ncbi Two novel mutations in the gonadotropin-releasing hormone receptor gene in Brazilian patients with hypogonadotropic hypogonadism and normal olfaction
    E M Costa
    Unidade de Endocrinologia do Desenvolvimento e Laboratório de Hormônios e Genética Molecular LIM 42, da Disciplina de Endocrinologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo 01060 970, Brazil
    J Clin Endocrinol Metab 86:2680-6. 2001
    ..A novel missense mutation, Arg(139)His, located in the conserved DRS motif at the junction of the third transmembrane and the second intracellular ..
  85. pmc Biochemical enrichment and biophysical characterization of a taste receptor for L-arginine from the catfish, Ictalurus puntatus
    William Grosvenor
    Monell Chemical Senses Center, Philadelphia, PA 19104 3308, USA
    BMC Neurosci 5:25. 2004
    ..Many of these receptors are sensitive to selected amino acids, one of these being a receptor for L-arginine (L-Arg)...
  86. ncbi Effects of arginine on pancreatic hormones and hepatic metabolism in rainbow trout
    T P Mommsen
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada
    Physiol Biochem Zool 74:668-78. 2001
    Arginine (Arg), injected intraperitoneally into rainbow trout (Oncorhynchus mykiss), increases plasma concentrations of glucagon, glucagon-like peptide-1 (GLP-1), and insulin by three- to 10-fold...
  87. ncbi Mechanisms that regulate the anticoagulant function of coagulation factor V
    E Thorelli
    Department of Clinical Chemistry, Lund University, University Hospital Malmo, Sweden
    Scand J Clin Lab Invest Suppl 229:19-26. 1999
    ..factor V is composed of domains A1-A2-B-A3-C1-C2 and is activated by thrombin through proteolytic cleavage at Arg 709, Arg 1018 and Arg 1545...
  88. pmc Arg-27, Arg-127 and Arg-155 in the beta-trefoil protein barley alpha-amylase/subtilisin inhibitor are interface residues in the complex with barley alpha-amylase 2
    K W Rodenburg
    Carlsberg Laboratory, Department of Chemistry, Copenhagen, Denmark
    Biochem J 309:969-76. 1995
    ..fragments of labelled BASI were purified by reverse-phase HPLC, and we concluded that the radiolabelled Arg-27, Arg-155 and most likely Arg-127, identified by amino acid, sequence and 14C analyses, are protected by AMY2...
  89. ncbi hOGG1 Ser326Cys and XRCC1 Arg399Gln polymorphisms associated with chronic obstructive pulmonary disease
    Shi fang Yang
    Department of Respiratory Medicine, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
    Chin Med J (Engl) 122:960-6. 2009
    ..e., part of them develop COPD. We investigated the association between polymorphisms in DNA repair genes hOGG1 (Ser326Cys) and XRCC1 (Arg399Gln), alone or in combination, and susceptibility of COPD...
  90. pmc Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial
    Michael E Wechsler
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Lancet 374:1754-64. 2009
    ..with asthma who are homozygous for arginine at the 16th amino acid position of the beta2-adrenergic receptor (B16 Arg/Arg) benefit less from treatment with longacting beta2 agonists and inhaled corticosteroids than do those ..
  91. ncbi Growth and immunity of broiler chicks as affected by dietary arginine
    M T Kidd
    Department of Poultry Science, Mississippi State University, MS 39762, USA
    Poult Sci 80:1535-42. 2001
    A dietary deficiency of Arg may suppress chick immune system functions; however, research evaluating immune function responsiveness of commercial broilers fed dietary Arg levels near NRC (1994) recommendations is sparse...
  92. ncbi [Autoradiography reporter gene (Ad5-tk carrying HSV1-tk gene) expression imaging in rat myocardium]
    Ying Liu
    Department of Nuclear Medicine, Union Hospital, Huazhong University of Science and Technology, Hubei Key Laboratory of Molecular Imaging, Wuhan 430022, China
    Zhonghua Xin Xue Guan Bing Za Zhi 37:925-30. 2009
    ..We explored the feasibility of the expression imaging of HSV1-tk reporter gene in rat myocardium by using SPECT reporter probe (131)I-2'-fluoro-2'-deoxy-1-beta-D-arabinofuranosyl-5-iodouracil ((131)I-FIAU) and autoradiography (ARG).
  93. doi Arginine-enriched total parenteral nutrition improves survival in peritonitis by normalizing NFkappaB activation in peritoneal resident and exudative leukocytes
    Chikara Ueno
    Department of Surgery, National Defense Medical College, Saitama, Japan
    Ann Surg 251:959-65. 2010
    ..We hypothesized that arginine (ARG)-enriched parenteral nutrition would normalize NFkappaB activation in peritoneal leukocytes, thereby improving the ..
  94. ncbi In vivo kinetics of human apolipoprotein A-I variants in rabbits
    K Saku
    Department of Internal Medicine, Fukuoka University School of Medicine, Japan
    Eur J Clin Invest 29:196-203. 1999
    ..In this study, we investigated the in vivo kinetics of several human apo A-I variants, which we had identified previously, in rabbits...
  95. doi Copper(II) complexes of L-arginine as netropsin mimics showing DNA cleavage activity in red light
    Ashis K Patra
    Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560 012, India
    Inorg Chem 48:2932-43. 2009
    Copper(II) complexes [Cu(L-arg)(2)](NO(3))(2) (1) and [Cu(L-arg)(B)Cl]Cl (2-5), where B is a heterocyclic base, namely, 2,2'-bipyridine (bpy, 2), 1,10-phenanthroline (phen, 3), dipyrido[3,2-d:2',3'-f]quinoxaline (dpq, 4), and dipyrido[3,..
  96. doi Development of a wound dressing composed of hyaluronic acid sponge containing arginine and epidermal growth factor
    Yasuhiro Matsumoto
    R and D Center for Artificial Skin, School of Allied Health Sciences, Kitasato University, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    J Biomater Sci Polym Ed 21:715-26. 2010
    ..Each spongy sheet was immersed into an aqueous solution of LMW-HA containing arginine (Arg) alone or both Arg and epidermal growth factor (EGF), and were then freeze-dried to prepare two types of product...
  97. pmc Evidence for participation of B1 and B2 kinin receptors in formalin-induced nociceptive response in the mouse
    C R Correa
    Department of Pharmacology, CCB, Universidade Federal de Santa Catarina, Florianopolis SC, Brazil
    Br J Pharmacol 110:193-8. 1993
    ..Similar results were obtained with the B2 antagonists NPC 349 (D-Arg[Hyp3,Thi5,8-D-Phe7]-BK) and NPC 567 (D-Arg[Hyp3, D-Phe7]-BK) (0.2 and 0.6 nmol/paw)...
  98. ncbi Synergistic therapeutic potential of dexamethasone and L-arginine in lipopolysaccharide-induced septic shock
    Saurabh Chatterjee
    Immunology and Hyperthermia Section, Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India
    J Surg Res 140:99-108. 2007
    ..L-arginine (L-arg), a semi-essential amino acid, depending on its metabolic pathway, becomes very essential in stress situations such ..
  99. doi Mass spectrometric characterization of modifications to angiotensin II by lipid peroxidation products, 4-oxo-2(E)-nonenal and 4-hydroxy-2(E)-nonenal
    Seon Hwa Lee
    Department of Bioanalytical Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba ku, Sendai, Japan
    Chem Res Toxicol 23:1771-85. 2010
    The octapeptide angiotensin II (Ang II; Asp(1)-Arg(2)-Val(3)-Tyr(4)-Ile(5)-His(6)-Pro(7)-Phe(8)) is the primary active hormone of the renin/angiotensin system (RAS) and has been implicated in various cardiovascular diseases...
  100. ncbi The tRNA-dependent activation of arginine by arginyl-tRNA synthetase requires inter-domain communication
    M Lazard
    Laboratoire d Enzymologie et Biochimie Structurales, UPR 9063 du Centre National de la Recherche Scientifique, Gif sur Yvette, 91190, France
    J Mol Biol 302:991-1004. 2000
    ..A conditional lethal mutant of Chinese hamster ovary cells that exhibits reduced arginyl-tRNA synthetase activity (Arg-1), and two of its derived revertants (Arg-1R4 and Arg-1R5) were analyzed at the structural and functional levels...
  101. ncbi A multitracer stable isotope quantification of the effects of arginine intake on whole body arginine metabolism in neonatal piglets
    Kristine L Urschel
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada
    Am J Physiol Endocrinol Metab 293:E811-8. 2007
    ..and femoral vein catheters for blood sampling, received a complete diet for 2 days and then either a generous (+Arg; 1.80 g x kg(-1) x day(-1); n = 5) or deficient (-Arg; 0.20 g.kg(-1).day(-1); n = 5) arginine diet for 5 days...

Research Grants69

  1. Regulation of a Novel Trypanosome RNA Binding Protein by Arginine Methylation
    Kaylen Lott; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The goal of this project is to identify mechanisms by which arginine (arg) methylation regulates gene expression in kinetoplastid parasites. Kinetoplastids, including Trypanosoma brucei, T...
  2. Essential Hypertension and Human Skin Blood Flow
    Lacy M Alexander; Fiscal Year: 2013
    ..to limit NO synthesis through constitutive NOSs due to preferential metabolism if the NOS substrate L-arginine (L-arg) by arginase-- and (3) an increase in oxidant production through uncoupled NOS due to inadequate L-arg and/or ..
  3. Thermally Triggered Multivalent Targeting of Tumors
    Ashutosh Chilkoti; Fiscal Year: 2013
    ..display a strong threshold effect in their cell penetration ability;below a threshold of 6 consecutive arginine (Arg) residues in the CPP, little cell uptake is observed, while above this threshold number of Arg residues, there is ..
  4. Immune-based nutrient deprivation and neurodegenerative disease
    Carol Anne Colton; Fiscal Year: 2013
    ..Increased activity of two enzymes are featured in immunosuppression;namely arginase (Arg) that uses arginine to make ornithine for polyamine and proline production and Indoleamine dioxygenase (IDO) that ..
  5. Arginine Availability and Metabolism in the Immune Evasion of H. pylori
    Keith T Wilson; Fiscal Year: 2013
    ..pylori fails to eradicate the organism. Our work has focused on the role of L-arginine (L-Arg) in the macrophage response to H. pylori...
  6. Effects of GSH +/- Arginine on Markers of Inflammation Among Adults with CVD Risk
    Christopher D Gardner; Fiscal Year: 2010
    ..will be randomly assigned for 8 weeks to either: 1) glutathione (GSH, n=30), 2) glutathione + arginine (GSH+Arg, n=30) or placebo (Plac, n=30). Data will be collected at baseline, 2, 4, and 8 weeks...
  7. Regulation of Lung Fibrosis by Alternatively Activated Macrophages and Arginase-1
    ROBERT MATTHEW TIGHE; Fiscal Year: 2013
    ..of targeted deletion of arginase-1 in macrophages and fibroblasts after non-infectious injury using a floxed arg-1 allele crossed with either a cre-recombinase strain that targets macrophages or fibroblasts...
  8. H. pylori induced DNA Damage and Immune Dysregulation
    Keith T Wilson; Fiscal Year: 2013
    ..apoptosis;and 2.) inhibition of nitric oxide (NO) synthesis, by inhibition of L-arginine (L-Arg)-dependent inducible nitric oxide (NO) synthase (iNOS) protein translation...
  9. Immunomodulatory effects of arginine supplementation in colitis and colon cancer
    Keith T Wilson; Fiscal Year: 2013
    ..We have been focusing on the role of the semi-essential amino acid, L-arginine (L-Arg) as a complementary and alternative medicine...
  10. Role of Ubiquitin in Cardiovascular System
    Song Li; Fiscal Year: 2013
    ..Conjugation of arginine (Arg) from Arg-tRNAArg to N-terminal aspartate (Asp), glutamate (Glu), or cysteine (Cys) is part of this proteolytic ..
  11. Hyperphenylalaninemia in cerebral malaria
    DONALD LEE GRANGER; Fiscal Year: 2010
    ..We discovered that Tanzanian children with CM have markedly low plasma levels of arginine (Arg) and markedly elevated phenylalanine (Phe). Arg is needed for synthesis of nitric oxide (NO) by NO synthases (NOS)...
  12. Protein Arginine Methylation in Trypanosomes
    Laurie K Read; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Protein arginine (arg) methylation is a common posttranslational modification of RNA binding proteins (RNA BPs) in yeast and mammals...
  13. Protein Arginine Methylation in Trypanosomes
    LAURIE READ; Fiscal Year: 2009
    Protein arginine (arg) methylation is a common posttranslational modification of RNA binding proteins (RNA BPs) in yeast and mammals...
  14. Arginase II, A Novel Target in Atherosclerosis
    Lewis H Romer; Fiscal Year: 2013
    ..or siRNA knockdown of mitochondrial processing peptidase (MPP) reduce the cytosolic abundance and activity of Arg-2 following Ox-LDL stimulation...
  15. Nitric oxide deficiency in chronic renal disease
    Chris Baylis; Fiscal Year: 2013
    ..removal of the endogenous NO synthase (NOS) inhibitor asymmetric dimethylarginine (ADMA);decreased substrate (L- Arg) availability due to reduction in renal L-Arg synthesis and also reductions in endothelial arginine transport;..
  16. Arginine Uptake Mechanisms Regulate Nitric Oxide in the Renal Vasculature
    David L Mattson; Fiscal Year: 2011
    ..Previous work from our laboratory demonstrated the importance of L-Arginine (L-Arg) uptake mechanisms in renal epithelial cells...
  17. A new post-translational modification, citrullination, changes in heart failure
    Jennifer E Van Eyk; Fiscal Year: 2013
    ..citrullination (deimination), a post-translational modification (PTM) altering the amino acid residue arginine (Arg), has recently become an area of interest due its emerging role in human auto-immune diseases...
  18. Arginine Availability, Modulated by MDSC, Regulates T Cell Function in Cancer
    Augusto C Ochoa; Fiscal Year: 2013
    Myeloid-Derived Suppressor Cells (MDSC) expressing Arginase (ARG) 1 are potent inhibitors of T cell function in cancer. MDSC deplete L-Arginine (L-Arg) in serum and the tumor microenvironment, severely impairing anti- tumor responses...
  19. Retention of somatic mutations in cancers by changes in pH sensing
    RYAN DANIEL HERNANDEZ; Fiscal Year: 2013
    ..To limit the scope and risk of testing this new idea we will focus on Arg>His mutations in cancers with the prediction that these mutations encode a gain of pH sensing...
    William Rosenblum; Fiscal Year: 1993
    ..Diameter will be monitored by TV microscopy. We will test the ability of L-Arg to dilate the arterioles and the ability of L-NMMA to block this dilation and to constrict the arterioles...
  21. Mechanism of Cell Surface Assembly Catalyzed by Sortases
    NARAYANA VL STHANAM; Fiscal Year: 2012
    ..the structures of enzyme sortases that are responsible for surface protein anchoring and identified a putative Cys-Arg catalytic dyad that is needed for sortase driven transpeptidation...
  22. Programmed translation arrest controlled by nascent peptides and antibiotics
    Nora Vazquez-Laslop; Fiscal Year: 2013
    ..The peptides of this class are characterize dby the presence of an 'RLR'(Arg-Leu-Arg) motif...
  23. Competing roles of microRNAs and RNA-binding proteins in drug addiction
    ..GU-rich sequence in mRNAs;2) Their binding sites are overrepresented in transcripts from an addiction-related gene (ARG) database;3) They show differential regulation by cocaine in addiction-related brain regions, with miR-495 being ..
  24. Impact of miR-495 vs. HuD in the Control of Addiction-Related Genes and Behavior
    ..GU-rich sequence in mRNAs;2) their binding sites are overrepresented in transcripts from an addiction-related gene (ARG) database;3) they show differential regulation by cocaine, with miR-495 downregulated and HuD upregulated in the ..
  25. Integrin alphaIIbbeta3 Structure, Activation, and Ligand Binding
    Barry Coller; Fiscal Year: 2013
    ..to activate [unreadable]IIb[unreadable]3 compared to [unreadable]IIb[unreadable]3 antagonists patterned on the Arg-Gly-Asp (RGD) cell recognition sequence...
  26. Identification of short functional motifs as potential drug targets for HIV
    Martin Schiller; Fiscal Year: 2009
    ..For example, the HIV envelope polyprotein (Env) contains a short consensus motif (Arg-x-Lys/Arg-Arg;[unreadable]x[unreadable]is any residue) for cleavage by the host protease, Furin...
    STEPHEN MOUNT; Fiscal Year: 1999
    ..Both proteins contain RRM regions and Ser/Arg rich regions...
  28. Targeted Plasma Peptidomics: Endogenous Mu-Opioid Receptor Peptides
    Brian Reed; Fiscal Year: 2013
    ..focusing on putative mu-opioid receptor peptide ligands ([unreadable]-endorphin, Met-enkephalin, Met-enkephalin-Arg-Phe, Met-enkephalin-Arg-Gly-Leu, and Leu- enkephalin)...
  29. Mechanisms of a Novel Chemotactic Cofactor for C5a
    Richard R Kew; Fiscal Year: 2011
    Activation of complement (C) with consequent generation of the C5-derived peptides C5a and C5a des Arg is a primary chemotactic stimulus at sites of infection or injury...
  30. Resolution of Epithelial Cell Hyperplasia
    Yohannes Tesfaigzi; Fiscal Year: 2013
    ..A polymorphism in the p53 gene at codon 72 (Arg/Pro) differentially affects Bcl-2 expression;p53Pro increases more efficiently than p53Arg, the pro-apoptotic ..
  31. The mechanism of Arg kinase activation by integrin B1
    Anthony J Koleske; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Integrin adhesion receptor signaling through the Abl and Arg nonreceptor tyrosine kinases activates several major cytoskeletal effectors to coordinate changes in cytoskeletal structure...
  32. Potential of a dominant-negative FGF mutant as a therapeutic in cancer
    Yoshikazu Takada; Fiscal Year: 2012
    ..We developed an FGF1 mutant (Arg-50 to Glu, R50E) that is defective in integrin binding but still binds to FGF-receptor or heparin...
  33. Structure and Function of Carboxypeptidases
    Randal A Skidgel; Fiscal Year: 2013
    ..carboxypeptidase (CP) M is an important regulator of the kallikrein- kinin system via its ability to generate des-Arg-kinin agonists of the G-protein coupled kinin B1 receptor (B1R)...
    ADRIE JC STEYN; Fiscal Year: 2012
    ..Previous work had shown that a point mutation (Arg ->His) in the 4.2 domain of RpoV, the principal sigma factor in 515 Mycobacterium bovis, is attenuating...
  35. Sequential ion/ion reactions for large peptide and whole protein characterization
    Joshua J Coon; Fiscal Year: 2013
    ..across the globe-nearly 300 to date-enabling access to numerous previously intractable problems such as mapping Arg methylation sites, increasing coverage of low molecular weight proteins, providing unambiguous PTM site assignment, ..
  36. Protease Engineering
    Brent L Iverson; Fiscal Year: 2012
    ..In particular, we will target Gln-His-Ala-Arg-Ala-Ser (QHA$RAS), residues 68-73 of the C-terminus of the C3a anaphylatoxin peptide...
    Andre J Ouellette; Fiscal Year: 2010
    ..b>Arg to Lys mutations will be made in Crp4 and proCrp4 at all positions, and the effects of mutagenesis on mechanisms of ..
  38. Novel Protein Phosphatases
    CAROLYN ANN WORBY; Fiscal Year: 2013
    ..of the protein tyrosine phosphatase (PTP) super family contain the highly conserved active site motif, Cys-x5-Arg (Cx5R), and are key mediators of a variety of cellular processes including growth, differentiation, motility, ..
  39. Computational Modeling of Post-translational Modifications in Proteins
    CHAYA K RAPP; Fiscal Year: 2011
    ..Hydrogen bonding will further be studied using molecular dynamics simulation of tripeptides Arg-Gly-xTyr and Lys-Gly-xTyr, with xTyr representing unmodified, sulfated, or phosphorylated tyrosine...
  40. Excessive Receptor Editing and Generation of Autoreactive Antibodies in SLE
    Zhixin Zhang; Fiscal Year: 2012
    ..naove B cells revealed many features of autoantibodies, such as long CDR3 regions with multiple positively charged Arg residues...
  41. Cross-talk Between Coagulation, Inflammation, and Immunity
    Lawrence L Leung; Fiscal Year: 2013
    ..vivo;the targets for CPB include bradykinin, C5a, the generation of plasmin and thrombin-cleaved osteopontin (OPN-Arg or OPN-R)...
  42. Translational Machinery in Stress Signaling and Tumor Suppression
    THOMAS J contact BEGLEY; Fiscal Year: 2010
    ..The yeast homolog of TRM9 enhances the translation of transcripts over-represented with specific ARG and GLU codons...
    CLAUDIA MORRIS; Fiscal Year: 2004
    ..L- Arginine (L-Arg) is the precursor to NO, and Dr...
  44. Genetic Analysis of FAK Activity
    David D Schlaepfer; Fiscal Year: 2012
    ..To support this model, we have generated a kinase-dead (KD) knock in point mutation (Lys-454 to Arg, R454) in exon 21 of mouse fak by homologous recombination...
  45. Functional characterization of the Bronx waltzer deafness gene
    Botond Banfi; Fiscal Year: 2013
    ..Our central hypothesis is that the bv mutation truncates the novel spliceosomal protein Ser/Arg-repetitive matrix 4 (SRRM4) in such a way that this protein fails to mediate key RNA splicing events necessary for ..
  46. A New Pathway for Neutrophil-induced Airway Inflammation
    J Edwin Blalock; Fiscal Year: 2013
    ..We have developed a potent antagonist, Arg-Thr-Arg, termed RTR, which binds PGP in solution and blocks its in vitro chemotactic activity and in vivo ..
  47. Role of Angiogenic CXC Chemokines in Intramembranous Bone Repair
    Dean T Yamaguchi; Fiscal Year: 2013
    ..CXC chemokines have a signature glu-leu-arg (ELR) sequence upstream to the CXC motif (ELR+ CXC chemokines) and are also uniquely angiogenic...
  48. Molecular mechanisms in the regulation of p53 functions by PAD4
    Yanming Wang; Fiscal Year: 2013
    ..g., histone acetyltransferases and protein Arg methyltransferases) and corepressors (e.g...
  49. Human Embryonic Stem Cells in Calcium Phosphate Constructs for Bone Regeneration
    HUAKUN XU; Fiscal Year: 2013
    ..While the Arg-Gly-Asp (RGD) peptide has been used in other scaffolds, there has been no report on its use in CPC...
  50. Initiation and Regulation of Chronic Autoimmune Prostate Inflammation
    Timothy L Ratliff; Fiscal Year: 2013
    ..Moreover, the cationic amino acid transporter that functions to deliver L-Arg to MDSC was identified...
  51. Dendritic Cell Activation by Mitochondrial Transcription Factor A
    Elliott D Crouser; Fiscal Year: 2010
    ..in promoting DC Type 1 interferon responses to TFAM and CpG DNA, 3) we will determine if the DNA-binding Pro-Lys-Arg sequence of TFAM protein is responsible for its pro- inflammatory biological activity...
  52. Targeting Entry Pathways in Leishmaniasis
    DAWN MARIE WETZEL; Fiscal Year: 2013
    ..integrin and Abl allow promastigote uptake by macrophages, 2) interactions among FcR, Src family kinases, and Arg allow amastigote uptake by macrophages, and 3) drugs that can inhibit these signaling proteins will decrease the ..
  53. Regulation of Food Intake and Body Weight by GLP-1
    ROGER REIDELBERGER; Fiscal Year: 2010
    ..GLP-1 and GLP-1(7-36)-Gly;other predicted/detected GLP-1 forms in gut tissue and blood include GLP-1(7-36)-Gly- Arg-Arg, GLP-1(1-36)-amide, GLP-1(1-36)-Gly, and GLP-1(1-36)-Gly-Arg-Arg...
  54. Regulation of dendritic spine shape and synapse and dendrite stability by Arg
    Anthony J Koleske; Fiscal Year: 2012
    ..shown that dendritic spine morphogenesis and later synapse and dendrite stability requires the Abl-related gene (Arg) nonreceptor tyrosine kinase, which acts downstream of integrin adhesion receptors to mediate changes in ..
  55. Rare Diseases Clinical Research Consortia (RDCRC) for the RDCR Network
    Mark L Batshaw; Fiscal Year: 2013
    ..AS) deficiency (Citrullinemia);Argininosuccinate lyase (AL) deficiency (Argininosuccinic aciduria);Arginase (ARG) deficiency (Argininemia);Hyperornithinemia, hyperammonemia, homocitrullinuria (HHH) syndrome;and Citrullinemia ..
  56. Lysyl Oxidase Propeptide: Breast Cancer Inhibitor
    Gail E Sonenshein; Fiscal Year: 2013
    ..Wildtype LOX-PP represents an important tumor suppressor, the activity of which is compromised by an Arg to Gln substitution. 2. A G473A (rs1800449) SNP in the LOX gene leads to increased risk of more invasive cancers...
  57. Novel role of AQP2 in cell migration and kidney tubular injury and repair
    HUA A LU; Fiscal Year: 2013
    ..We have identified a conserved extracellular Arg-Gly-Asp (RGD) integrin-binding motif in AQP2, through which it interacts with integrin [unreadable]1, modulates the ..
  58. The Survival from Acute Myocardial Infarction (SAMI) Initiative
    Henry H Ting; Fiscal Year: 2013
    ..ACC will leverage the ARG of 725 participating hospitals for patients with AMI, existing infrastructure for collecting and reporting outcomes ..
  59. STAT1 Activation and HPP1 Tumor Suppression
    David Shibata; Fiscal Year: 2013
    ..is postulated to be an EGF-like ligand and contains an EGF-like domain in its extracellular domain that has a His/Arg alteration that may bind to the ErbB receptor family...
  60. Supplement to Regulation of invadopodia formation in breast cancer cells
    Anthony J Koleske; Fiscal Year: 2013
    ..We have shown that integrin -mediated adhesion stimulates the Arg nonreceptor tyrosine kinase to interact with the actin polymerization regulators cortactin, N-WASp, and Vav2 at ..
  61. Signal Transduction &Actin During Amoeboid Chemotaxis
    John S Condeelis; Fiscal Year: 2013
    ..Cofilin and N-WASp dependent actin polymerization;4. Arg-dependent cortactin phosphorylation which regulates #s 1-3;5...
  62. Role of apoE structure and metabolism in neurodegeneration
    Robert W Mahley; Fiscal Year: 2012
    ..The brains of human apoE isoform knock in mice and our Arg-61 apoE mouse model in which domain interaction was introduced, contain lower levels of apoE4 and Arg-61 mouse apoE ..
  63. Functional crosstalk of TGF-beta/Smad signaling with methyl transferases
    RIK M DERYNCK; Fiscal Year: 2013
    ..In Aim 1 we will define the role of the Arg methyl transferase PRMT1 in Smad6 and Smad7 function...
  64. Use of Micro-RNA Arrays to Identify MDSC Functional Pathways and Markers
    Timothy L Ratliff; Fiscal Year: 2013
    ..Only tumor- or inflammation-derived MDSC to express Arginase I (Arg-I) and inducible nitric oxide synthase (iNOS) and suppress T cell responses, clearly localizing functional MDSC to ..
    Vivian Hook; Fiscal Year: 2009
    ..These findings indicate that Arg/Lys aminopeptidase is then necessary to remove such basic residues...
  66. POMC Processing and Beta-Endorphine-Related Opioid Peptides
    Vivian Y H Hook; Fiscal Year: 2010
    ..L for dibasic processing sites generates peptide intermediates with NH2-terminal basic residues, indicating that Arg/Lys aminopeptidase is then necessary to remove such basic residues...
    MATTHEW SACHS; Fiscal Year: 2009
    ..attenuator peptide (AAP) is encoded by a uORF in the 5'-leader regions of mRNAs specifying a fungal arginine (Arg) biosynthetic enzyme;it reduces gene expression in response to Arg...
    Satya Kalra; Fiscal Year: 2000
    ..identified messenger molecules produced by enzymatic conversion of the common precursor amino acid, L-arginine (L-Arg)...
    PHILIP CRADDOCK; Fiscal Year: 1980
    ..shown that, in both man and animals, intravascular complement activation (and the concomitant generation of C5a des arg) leads to augmented granulocyte adhesiveness and auto-aggregation...