ABCC9

Summary

Gene Symbol: ABCC9
Description: ATP binding cassette subfamily C member 9
Alias: ABC37, ATFB12, CANTU, CMD1O, SUR2, ATP-binding cassette sub-family C member 9, ATP-binding cassette transporter sub-family C member 9, ATP-binding cassette, sub-family C (CFTR/MRP), member 9, sulfonylurea receptor 2
Species: human

Top Publications

  1. doi Effects of ATP-sensitive potassium channels on the expression of P21, P27 and leptin
    Yaohui Wang
    Department of Pathophysiology, Zunyi Medical College, Zunyi, China
    J Huazhong Univ Sci Technolog Med Sci 29:8-11. 2009
  2. ncbi Syntaxin-1A inhibits cardiac KATP channels by its actions on nucleotide binding folds 1 and 2 of sulfonylurea receptor 2A
    Youhou Kang
    Department of Medicine, University of Toronto, Toronto M5S 1A8, Canada
    J Biol Chem 279:47125-31. 2004
  3. ncbi A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels
    N Inagaki
    Division of Molecular Medicine Center for Biomedical Science, Chiba University School of Medicine, Chuo Ku, Chiba 260, Japan
    Neuron 16:1011-7. 1996
  4. ncbi Cloning, tissue expression, and chromosomal localization of SUR2, the putative drug-binding subunit of cardiac, skeletal muscle, and vascular KATP channels
    W A Chutkow
    Department of Medicine, Howard Hughes Medical Institute, Chicago, Illinois, USA
    Diabetes 45:1439-45. 1996
  5. ncbi Toward understanding the assembly and structure of KATP channels
    L Aguilar-Bryan
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas, USA
    Physiol Rev 78:227-45. 1998
  6. pmc ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating
    Martin Bienengraeber
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, Mayo Foundation, Rochester, Minnesota 55905, USA
    Nat Genet 36:382-7. 2004
  7. ncbi Physical association between recombinant cardiac ATP-sensitive K+ channel subunits Kir6.2 and SUR2A
    E Lorenz
    Department of Internal Medicine, Mayo Clinic, Mayo Foundation, Rochester, Minnesota 55905, USA
    J Mol Cell Cardiol 31:425-34. 1999
  8. ncbi Molecular mechanisms underlying ketamine-mediated inhibition of sarcolemmal adenosine triphosphate-sensitive potassium channels
    Takashi Kawano
    Department of Anesthesiology, Tokushima University School of Medicine, Tokushima, Japan
    Anesthesiology 102:93-101. 2005
  9. pmc Differential K(ATP) channel pharmacology in intact mouse heart
    Alexey V Glukhov
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    J Mol Cell Cardiol 48:152-60. 2010
  10. pmc Phosphoinositides decrease ATP sensitivity of the cardiac ATP-sensitive K(+) channel. A molecular probe for the mechanism of ATP-sensitive inhibition
    Z Fan
    Department of Physiology, University of Tennessee, College of Medicine, Memphis, Tennessee 38163, USA
    J Gen Physiol 114:251-69. 1999

Research Grants

  1. Molecular Regulation of Cardiac KATP Channels in Ischemia
    Jonathan C Makielski; Fiscal Year: 2013
  2. Genetic Markers of GIK Effect in Acute Coronary Syndrome in the IMMEDIATE Trial
    Inga Peter; Fiscal Year: 2012
  3. Molecular Regulation of Cardiac KATP Channels in Ischemia
    Jonathan C Makielski; Fiscal Year: 2012
  4. Redox Regulation of ATP Sensitive Potassium Channels
    Li Bao; Fiscal Year: 2012
  5. The Role of Sulfonylurea Receptor 2 Splice Variants in Myocardial Function
    John P Fahrenbach; Fiscal Year: 2011
  6. Echinocandin Reduced/Increased Susceptibility: Mechanism
    Santosh Kumar Katiyar; Fiscal Year: 2013
  7. Mechanisms underlie inverse gender discrepancy in ischemic protection
    Nian Qing Shi; Fiscal Year: 2010
  8. BRUCE A BEUTLER; Fiscal Year: 2016
  9. Development of HTS Assay:PK(ATP)FLIPR Channels (RMI)
    Xinmin Xie; Fiscal Year: 2005
  10. Colin G Nichols; Fiscal Year: 2016

Scientific Experts

Detail Information

Publications164 found, 100 shown here

  1. doi Effects of ATP-sensitive potassium channels on the expression of P21, P27 and leptin
    Yaohui Wang
    Department of Pathophysiology, Zunyi Medical College, Zunyi, China
    J Huazhong Univ Sci Technolog Med Sci 29:8-11. 2009
    ..The results showed that the expression of SUR2, not SUR1 was detected in adipose tissue, preadipocytes and adipocytes...
  2. ncbi Syntaxin-1A inhibits cardiac KATP channels by its actions on nucleotide binding folds 1 and 2 of sulfonylurea receptor 2A
    Youhou Kang
    Department of Medicine, University of Toronto, Toronto M5S 1A8, Canada
    J Biol Chem 279:47125-31. 2004
    ....
  3. ncbi A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels
    N Inagaki
    Division of Molecular Medicine Center for Biomedical Science, Chiba University School of Medicine, Chuo Ku, Chiba 260, Japan
    Neuron 16:1011-7. 1996
    We have cloned an isoform of the sulfonylurea receptor (SUR), designated SUR2. Coexpression of SUR2 and the inward rectifier K+ channel subunit Kir6...
  4. ncbi Cloning, tissue expression, and chromosomal localization of SUR2, the putative drug-binding subunit of cardiac, skeletal muscle, and vascular KATP channels
    W A Chutkow
    Department of Medicine, Howard Hughes Medical Institute, Chicago, Illinois, USA
    Diabetes 45:1439-45. 1996
    ..Northern blotting showed that the highest expression of the SUR2 isoforms is in the heart and skeletal muscle, with lower levels in all other tissues...
  5. ncbi Toward understanding the assembly and structure of KATP channels
    L Aguilar-Bryan
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas, USA
    Physiol Rev 78:227-45. 1998
    ..The availability of cloned KATP channel genes opens the way for characterization of this family of ion channels and identification of additional genetic defects...
  6. pmc ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating
    Martin Bienengraeber
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, Mayo Foundation, Rochester, Minnesota 55905, USA
    Nat Genet 36:382-7. 2004
    ..with heart failure and rhythm disturbances due to idiopathic dilated cardiomyopathy identified two mutations in ABCC9, which encodes the regulatory SUR2A subunit of the cardiac K(ATP) channel...
  7. ncbi Physical association between recombinant cardiac ATP-sensitive K+ channel subunits Kir6.2 and SUR2A
    E Lorenz
    Department of Internal Medicine, Mayo Clinic, Mayo Foundation, Rochester, Minnesota 55905, USA
    J Mol Cell Cardiol 31:425-34. 1999
    ..The demonstration of complex formation between Kir6.2 and SUR2A indicates that the structural basis for channel function may rely on direct physical interaction of the two subunits...
  8. ncbi Molecular mechanisms underlying ketamine-mediated inhibition of sarcolemmal adenosine triphosphate-sensitive potassium channels
    Takashi Kawano
    Department of Anesthesiology, Tokushima University School of Medicine, Tokushima, Japan
    Anesthesiology 102:93-101. 2005
    ..1 or Kir6.2) and sulfonylurea receptors (SUR1, SUR2A, or SUR2B)...
  9. pmc Differential K(ATP) channel pharmacology in intact mouse heart
    Alexey V Glukhov
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    J Mol Cell Cardiol 48:152-60. 2010
    Classically, cardiac sarcolemmal K(ATP) channels have been thought to be composed of Kir6.2 (KCNJ11) and SUR2A (ABCC9) subunits...
  10. pmc Phosphoinositides decrease ATP sensitivity of the cardiac ATP-sensitive K(+) channel. A molecular probe for the mechanism of ATP-sensitive inhibition
    Z Fan
    Department of Physiology, University of Tennessee, College of Medicine, Memphis, Tennessee 38163, USA
    J Gen Physiol 114:251-69. 1999
    ..clamp technique in cardiac myocytes and in COS-1 cells in which the cardiac isoform of the sulfonylurea receptor, SUR2, was coexpressed with the inwardly rectifying channel Kir6.2...
  11. pmc Proximal C-terminal domain of sulphonylurea receptor 2A interacts with pore-forming Kir6 subunits in KATP channels
    Richard D Rainbow
    Department of Cell Physiology and Pharmacology, University of Leicester, University Road, Leicester LE1 9HN, UK
    Biochem J 379:173-81. 2004
    ..ATP- and glibenclamide-sensitive K+ currents were decreased in HEK-293 cells expressing full-length Kir6 and SUR2 subunits that were transiently transfected with fragments rSUR2A-CTA, rSUR2A-CTC and rSUR2A-CTE (residues 1294-1359)..
  12. pmc Glucose-receptive neurones in the rat ventromedial hypothalamus express KATP channels composed of Kir6.1 and SUR1 subunits
    K Lee
    Parke Davis Neuroscience Research Centre, Cambridge University Forvie Site, Cambridge CB2 2QB, UK
    J Physiol 515:439-52. 1999
    ..1 and SUR1 but not Kir6.2 or SUR2. 6...
  13. ncbi Nicorandil protects against lethal ischemic ventricular arrhythmias and up-regulates endothelial nitric oxide synthase expression and sulfonylurea receptor 2 mRNA in conscious rats with acute myocardial infarction
    Shigeo Horinaka
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi, 321 0293, Japan
    Cardiovasc Drugs Ther 18:13-22. 2004
    ..At 24 hours after treatment, eNOS, iNOS, and SUR2 mRNA levels and eNOS, iNOS expression in the left ventricle were determined by reverse transcription polymerase ..
  14. pmc Coassembly of different sulfonylurea receptor subtypes extends the phenotypic diversity of ATP-sensitive potassium (KATP) channels
    Adam Wheeler
    Department of Physiology and Biophysics, Case Western Reserve University, School of Medicine, Cleveland, Ohio, USA
    Mol Pharmacol 74:1333-44. 2008
    ..SUR1- but not SUR2-containing channels are highly sensitive to metabolic inhibition and diazoxide, whereas SUR2 channels are sensitive ..
  15. ncbi Spontaneous coronary vasospasm in KATP mutant mice arises from a smooth muscle-extrinsic process
    Rahul Kakkar
    Department of Medicine, The University of Chicago, IL 60637, USA
    Circ Res 98:682-9. 2006
    ..Two transgenic founder lines were generated and independently bred to sulfonylurea receptor 2 (SUR2) null mice to generate mice that restored expression of KATP channels in vascular smooth muscle...
  16. doi Sesquiterpenoids from antidiabetic Psacalium decompositum block ATP sensitive potassium channels
    Maria G Campos
    Unit of Medical Research in Pharmacology, National Medical Center SXXI, IMSS, Mexico, Mexico
    J Ethnopharmacol 123:489-93. 2009
    ....
  17. pmc Suppressed Ca2+/CaM/CaMKII-dependent K(ATP) channel activity in primary afferent neurons mediates hyperalgesia after axotomy
    Takashi Kawano
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Proc Natl Acad Sci U S A 106:8725-30. 2009
    ..Immunohistochemistry identified the presence of K(ATP) channel subunits SUR1, SUR2, and Kir6.2 but not Kir6.1, and pCaMKII in neurofilament 200-positive DRG somata...
  18. pmc The molecular basis of the specificity of action of K(ATP) channel openers
    C Moreau
    CEA, DBMS, Biophysique Moléculaire et Cellulaire UMR CNRS UJF CEA 5090, 17 rue des Martyrs, 38054 Grenoble, France
    EMBO J 19:6644-51. 2000
    ..g. pinacidil, cromakalim, nicorandil) act specifically on the SUR2 muscle isoforms but, except for diazoxide, remain ineffective on the SUR1 neuronal/pancreatic isoform...
  19. ncbi Involvement of ATP-sensitive potassium channels in proliferation and differentiation of rat preadipocytes
    Yao Hui Wang
    Department of Pathophysiology, Huazhong University of Science and Technology, Wuhan 430030, China
    Sheng Li Xue Bao 59:8-12. 2007
    ..We examined the expression of sulphonylurea receptor 2 (SUR2) mRNA in preadipocytes and adipocytes obtained by inducing for 5 d and the effects of the inhibitor (glibenclamide) ..
  20. ncbi Nicorandil enhances cardiac endothelial nitric oxide synthase expression via activation of adenosine triphosphate-sensitive K channel in rat
    S Horinaka
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Tochigi, Japan
    J Cardiovasc Pharmacol 38:200-10. 2001
    ..e., an ATP-binding cassette protein sulfonylurea receptor (SUR2) and a pore-forming inward rectifier (Kir6.1 or 6.2)...
  21. doi Human hair follicles contain two forms of ATP-sensitive potassium channels, only one of which is sensitive to minoxidil
    Katie Shorter
    Department of Biomedical Sciences, University of Bradford, Bradford, BD7 1DP, UK
    FASEB J 22:1725-36. 2008
    ..2/SUR1 and Kir6.1/SUR2B; minoxidil only stimulates SUR2 channels...
  22. pmc Molecular identification and functional characterization of a mitochondrial sulfonylurea receptor 2 splice variant generated by intraexonic splicing
    Bin Ye
    Department of Medicine, University of Wisconsin, Madison, WI 53706, USA
    Circ Res 105:1083-93. 2009
    ..Cardioprotective pathways may involve a mitochondrial ATP-sensitive potassium (mitoK(ATP)) channel but its composition is not fully understood...
  23. doi K(ATP) channel openers protect mesencephalic neurons against MPP+-induced cytotoxicity via inhibition of ROS production
    Juan Xie
    Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, People s Republic of China
    J Neurosci Res 88:428-37. 2010
    ..However, cromakalim (Cro), an opener of Kir6.1/SUR2 but not Kir6.2/SUR1 K(ATP) channels, failed to protect against MPP(+)-induced cytotoxicity...
  24. doi Iptakalim protects against hypoxic brain injury through multiple pathways associated with ATP-sensitive potassium channels
    H L Zhu
    Department of Environmental Medicine, Tianjin Institute of Hygiene and Environmental Medicine, Tianjin 300050, China
    Neuroscience 157:884-94. 2008
    ..In this study, adult Wistar rats were treated with iptakalim, a new KATP channel opener, which is selective for SUR2 type KATP channels, by intragastric administration at doses of 2, 4, or 8 mg/kg/day for 7 days before being exposed ..
  25. ncbi [Molecular and functional diversity of ATP-sensitive K+ channels: the pathophysiological roles and potential drug targets]
    Haruaki Nakaya
    Department of Pharmacology, Chiba University Graduate School of Medicine, Japan
    Nihon Yakurigaku Zasshi 122:243-50. 2003
    ..1 or Kir6.2) and the regulatory subunit sulfonylurea receptors (SUR1 or SUR2)...
  26. doi Molecular and functional characterization of a new potassium conductance in mouse ventricular fibroblasts
    Najate Benamer
    Institut de Physiologie et Biologie Cellulaires, CNRS UMR 6187, Universite de Poitiers, France
    J Mol Cell Cardiol 46:508-17. 2009
    ..Among potassium channel transcripts which were screened by high-throughput real-time PCR, SUR2 and Kir6.1 mRNAs were found to be the most abundant in ventricular fibroblasts...
  27. ncbi A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel
    S Isomoto
    Department of Pharmacology II, Faculty of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565, Japan
    J Biol Chem 271:24321-4. 1996
    ..Sequence analysis indicated that this clone is a variant of cardiac type sulfonylurea receptor (SUR2)...
  28. pmc Identification of an ATP-sensitive potassium channel current in rat striatal cholinergic interneurones
    K Lee
    Parke Davis Neuroscience Research Centre, Cambridge University Forvie Site, UK
    J Physiol 510:441-53. 1998
    ..1 and SUR1 but not Kir6.2 or SUR2. 6...
  29. doi KATP channel subunits are expressed in the epididymal epithelium in several mammalian species
    Pascale Lybaert
    Laboratory of Experimental Hormonology, Faculty of Medicine, Universite Libre de Bruxelles ULB, B 1070 Brussels, Belgium
    Biol Reprod 79:253-61. 2008
    ..A positive immunostaining for Kir6.2 (KCNJ11) and SUR2 (ABCC9) was observed by immunoenzymatic and immunofluorescent approaches in the principal epithelial cells throughout all ..
  30. pmc Metabolomic, transcriptional, hormonal, and signaling cross-talk in superroot2
    Marc Morant
    Plant Biochemistry Laboratory, Department of Plant Biology and Biotechnology, University of Copenhagen, 40 Thorvaldsensvej, Frederiksberg C, Copenhagen, Denmark
    Mol Plant 3:192-211. 2010
    Auxin homeostasis is pivotal for normal plant growth and development. The superroot2 (sur2) mutant was initially isolated in a forward genetic screen for auxin overproducers, and SUR2 was suggested to control auxin conjugation and thereby ..
  31. doi The role of survivin2 in primitive hematopoiesis during zebrafish development
    A C H Ma
    Division of Haematology and Bone Marrow Transplantation, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    Leukemia 23:712-20. 2009
    ..In this study, we examined survivin2 (sur2) with particular reference to its role in primitive hematopoiesis during zebrafish development...
  32. pmc Identification of two Mycobacterium tuberculosis H37Rv ORFs involved in resistance to killing by human macrophages
    B H Miller
    Department of Microbiology and Immunology, Emory University School of Medicine and Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    BMC Microbiol 1:26. 2001
    ..tuberculosis H37Rv genomic DNA, was passed through THP-1 human macrophages three times...
  33. ncbi Microarray analysis of blood microvessels from PDGF-B and PDGF-Rbeta mutant mice identifies novel markers for brain pericytes
    Cecilia Bondjers
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77, Stockholm, Sweden
    FASEB J 20:1703-5. 2006
    ..1 (also known as Kcnj8) and sulfonylurea receptor 2, (SUR2, also known as Abcc9), both part of the same channel complex, as well as delta homologue 1 (DLK1) ..
  34. pmc Mice lacking sulfonylurea receptor 2 (SUR2) ATP-sensitive potassium channels are resistant to acute cardiovascular stress
    Douglas Stoller
    Committee on Cell Physiology, The University of Chicago, Chicago, IL 60637, USA
    J Mol Cell Cardiol 43:445-54. 2007
    ..Cardiomyocyte K(ATP) channels are composed of the pore-forming Kir6.2 subunit and the regulatory sulfonylurea receptor 2 (SUR2)...
  35. pmc Impaired exercise tolerance and skeletal muscle myopathy in sulfonylurea receptor-2 mutant mice
    Douglas Stoller
    Committee on Cellular and Molecular Physiology, The University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1144-53. 2009
    ..b>SUR2 mutant mice lack full-length K(ATP) channels in striated and smooth muscle and display a complex phenotype of ..
  36. ncbi Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit
    Jennitte L Stevens
    Molecular Biology Institute, University of California, Los Angeles, 611 Charles Young Drive East, Los Angeles, CA 90095, USA
    Science 296:755-8. 2002
    b>Sur2 is a metazoan Mediator subunit that interacts with the adenovirus E1A protein and functions in a mitogen-activated protein kinase pathway required for vulva development in Caenorhabditis elegans...
  37. ncbi Post-infarction treatment with simvastatin reduces myocardial no-reflow by opening of the KATP channel
    Yue jin Yang
    Department of Cardiology, Cardiovascular Institute and Fu Wai Heart Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Bei Li Shi Road 167, West City District, Beijing, 100037, China
    Eur J Heart Fail 9:30-6. 2007
    ..However, it remains unknown whether post-infarction treatment with simvastatin can also reduce myocardial no-reflow for which suppression of adenosine triphosphate-sensitive K+ (K(ATP)) channel opening is an important mechanism...
  38. doi ATP-sensitive potassium currents in rat primary afferent neurons: biophysical, pharmacological properties, and alterations by painful nerve injury
    T Kawano
    Department of Anesthesiology, Anesthesia Research MEB, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neuroscience 162:431-43. 2009
    ..Using specific antibodies, we identified SUR1, SUR2, and Kir6.2 but not Kir6.1 subunits in DRGs...
  39. ncbi Topology mapping of the amino-terminal half of multidrug resistance-associated protein by epitope insertion and immunofluorescence
    C Kast
    Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 272:26479-87. 1997
    ..cadmium factor 1 and yeast oligomycin resistance I proteins, and the mammalian sulfonylurea receptors SUR1 and SUR2. Hydropathy analysis of these proteins predicts a unique membrane-associated region at the amino terminus followed ..
  40. pmc Myocardial ischemia induces differential regulation of KATP channel gene expression in rat hearts
    M Akao
    Cardiovascular Division of Internal Medicine, Kyoto University Hospital, Kyoto 606, Japan
    J Clin Invest 100:3053-9. 1997
    ..1 and/or Kir6.2) subunit and the sulfonylurea receptor (SUR2). This channel is activated during myocardial ischemia and protects the heart from ischemic injury...
  41. ncbi Antisense oligodeoxynucleotides of sulfonylurea receptors inhibit ATP-sensitive K+ channels in cultured neonatal rat ventricular cells
    H Yokoshiki
    Department of Molecular and Cellular Physiology, College of Medicine, University of Cincinnati, 231 Bethesda Avenue, PO Box 670576, Cincinnati, OH 45267 0576, USA
    Pflugers Arch 437:400-8. 1999
    ..8 pA/pF in control (n=48), 34.3+/-3.5 pA/pF in AS-SUR1 (n=21, P<0.05 vs control), and 23.5+/-3.4 pA/pF in AS-SUR2 (n=17, P<0.01 vs control). As a control, scramble oligonucleotides had no effect...
  42. ncbi Alternative splicing of sur2 Exon 17 regulates nucleotide sensitivity of the ATP-sensitive potassium channel
    W A Chutkow
    Departments of Medicine and Pharmacological and Physiological Sciences, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 274:13656-65. 1999
    ..has shown that alternative usage of exons 14, 39, and 40 of the muscle-specific KATP channel regulatory subunit, sur2, occurs in tissue-specific patterns...
  43. ncbi Stoichiometry of sulfonylurea-induced ATP-sensitive potassium channel closure
    H Dorschner
    Institut fur Pharmakologie und Toxikologie, Universität Braunschweig, Mendelssohnstrabetae 1, 38106 Braunschweig, Germany
    Mol Pharmacol 55:1060-6. 1999
    ..Affinities of sulfonylureas for rat SUR2A, rat or human SUR2B, and a SUR2 chimera containing the C-terminal 42 amino acids of SUR1 did not differ significantly, implying that the C terminus ..
  44. ncbi Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary
    I Wulfsen
    Abteilung fur angewandte Physiologie, Institut fur Physiologie, Universitatsklinikum Hamburg Eppendorf, Universitat Hamburg, Hamburg, Germany
    J Neuroendocrinol 12:263-72. 2000
    ..4, Kir4.1, Kir6.1, Kir6. 2) were found. In addition, all tested auxiliary subunits (Kvbeta1-Kvbeta3, minK, SUR1, SUR2) are expressed in the pituitary...
  45. ncbi Sulfonylurea stimulation of insulin secretion
    Peter Proks
    University Laboratory of Physiology, Oxford University, UK
    Diabetes 51:S368-76. 2002
    ..Thus tolbutamide and gliclazide block channels containing SUR1 (beta-cell type), but not SUR2 (cardiac, smooth muscle types), whereas glibenclamide, glimepiride, repaglinide, and meglitinide block both types ..
  46. pmc Functional involvement of sulphonylurea receptor (SUR) type 1 and 2B in the activity of pig urethral ATP-sensitive K+ channels
    Takakazu Yunoki
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi Ward, Fukuoka 812 8582, Japan
    Br J Pharmacol 139:652-60. 2003
    ..In voltage-clamp experiments, not only diazoxide, a SUR1 and weak SUR2B activator, but also pinacidil, a selective SUR2 activator, caused an inward current at a holding potential of -50 mV in symmetrical 140 mM K(+) conditions...
  47. pmc Activation of ATP-sensitive K+ (K(ATP)) channels by H2O2 underlies glutamate-dependent inhibition of striatal dopamine release
    Marat V Avshalumov
    Department of Physiology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 100:11729-34. 2003
    ..1 (SUR1)selective KATP-channel opener, prevented DA modulation by H2O2, glutamate, and GABA, whereas cromakalim, a SUR2-selective opener, did not...
  48. ncbi The nucleotide-binding domains of sulfonylurea receptor 2A and 2B play different functional roles in nicorandil-induced activation of ATP-sensitive K+ channels
    Mitsuhiko Yamada
    Department of Pharmacology II, Graduate School of Medicine, Osaka University, Suita, Japan
    Mol Pharmacol 65:1198-207. 2004
    ..2 than SUR2A/Kir6.2 channels in the presence of ATP alone. Thus, C42 modulates the interaction of both NBDs with intracellular nucleotides...
  49. pmc Requirement of Sur2 for efficient replication of mouse adenovirus type 1
    Lei Fang
    Department of Microbiology and Immunology, University of Michigan Medical School, 1150 W Medical Center Dr, 6723 Medical Science Bldg II, Ann Arbor, MI 48109 0620, USA
    J Virol 78:12888-900. 2004
    ..We identified mouse Sur2, a subunit of Mediator complex, as a protein that binds to MAV-1 E1A...
  50. pmc The mutation Y1206S increases the affinity of the sulphonylurea receptor SUR2A for glibenclamide and enhances the effects of coexpression with Kir6.2
    Damian Stephan
    Department of Pharmacology and Toxicology, Medical Faculty, Pharmakologisches Institut Abt Molekularpharmakologie, University of Tubingen, Wilhelmstr 56, Tubingen, D 72074 Germany
    Br J Pharmacol 144:1078-88. 2005
    ..the changes were similar to those observed with SUR2B(Y1206S), suggesting that the differences in the last 42 carboxy-terminal amino acids of SUR2A and 2B are of limited influence on the binding of GBC and P1075 to the SUR2 isoforms.
  51. ncbi Studies of ATP-sensitive potassium channels on 6-hydroxydopamine and haloperidol rat models of Parkinson's disease: implications for treating Parkinson's disease?
    Sen Wang
    Department of Pharmacology and Neurobiology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, China
    Neuropharmacology 48:984-92. 2005
    ..The results show that Kir6.2 and SUR2 expression in the PFC, Kir6.1, Kir6.2 and SUR1 expression in the striatum, and Kir6.1 and Kir6...
  52. ncbi ATP-binding cassette transporters in the heart
    Thomas F Solbach
    Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nuremberg, 91054 Erlangen, Germany
    Trends Cardiovasc Med 16:7-15. 2006
    ..Many human ABC transporters, such as ABCB1 (P-glycoprotein), ABCC5 (MRP5), or ABCC9 (SUR2), are expressed in the heart, suggesting an important role of these transporters in cardiac drug effects or ..
  53. ncbi Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins
    Roger G Deeley
    Division of Cancer Biology and Genetics, Cancer Research Institute and Department of Biochemistry, Queen s University Kingdom, Ontario, Canada
    Physiol Rev 86:849-99. 2006
    ..with the cystic fibrosis conductance regulator (CFTR/ABCC7) and the sulfonylurea receptors (SUR1/ABCC8 and SUR2/ABCC9) comprise the 13 members of the human "C" branch of the ATP binding cassette (ABC) superfamily...
  54. pmc SVF1 regulates cell survival by affecting sphingolipid metabolism in Saccharomyces cerevisiae
    Jennifer L Brace
    Johns Hopkins University, Baltimore, Maryland 21231, USA
    Genetics 175:65-76. 2007
    ..A genetic interaction between SVF1 and SUR2 demonstrates that both factors are required for optimal growth and survival, and phenotypic similarities between ..
  55. pmc Cardiac sulfonylurea receptor short form-based channels confer a glibenclamide-insensitive KATP activity
    Jie lin Pu
    Department of Medicine, University of Wisconsin, 1300, University Ave, Room 24, SMI Building, Madison, WI 53706, USA
    J Mol Cell Cardiol 44:188-200. 2008
    The cardiac sarcolemmal ATP-sensitive potassium channel (K(ATP)) consists of a Kir6.2 pore and an SUR2 regulatory subunit, which is an ATP-binding cassette (ABC) transporter...
  56. ncbi Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development
    Shu Feng Zhou
    Division of Chinese Medicine, School of Health Sciences, WHO Collaborating Center for Traditional Medicine, RMIT University, Victoria, Australia
    Curr Med Chem 15:1981-2039. 2008
    ..ABCC7 is cystic fibrosis transmembrane conductance regulator; ABCC8 and ABCC9 are the sulfonylurea receptors which constitute the ATP-sensing subunits of a complex potassium channel...
  57. pmc Varicella-zoster virus IE62 protein utilizes the human mediator complex in promoter activation
    Min Yang
    Department of Microbiology and Immunology and Witebsky Center for Microbial Pathogenesis and Immunology, University at Buffalo, Buffalo, New York, USA
    J Virol 82:12154-63. 2008
    ..In contrast, the Med23 subunit (Sur2/TRAP150beta/DRIP130/CRSP130) of the Mediator complex is not essential for IE62-mediated activation...
  58. doi Patents related to therapeutic activation of K(ATP) and K(2P) potassium channels for neuroprotection: ischemic/hypoxic/anoxic injury and general anesthetics
    Susan I V Judge
    University of Maryland School of Medicine, MS Center of Excellence East, VA Maryland Health Care System, Department of Neurology, BRB 12 040, 655 West Baltimore Street, Baltimore, MD 21201, USA
    Expert Opin Ther Pat 19:433-60. 2009
    ..which belong to the family of inwardly rectifying K(+) channels (K(ir)) and contain a sulfonylurea subunit (SUR1 or SUR2) combined with either K(ir)6.1 (KCNJ8) or K(ir)6...
  59. pmc PKC-permitted elevation of sarcolemmal KATP concentration may explain female-specific resistance to myocardial infarction
    Andrew G Edwards
    University of Colorado at Boulder, 354 UCB, Boulder, CO 80309 0354, USA
    J Physiol 587:5723-37. 2009
    ..HMR, 27 +/- 3%), and PKC blockade had no additional effect (HMR + Chel, 26 +/- 2%). The prevalence of Kir6.2 and SUR2 was higher in the sarcolemmal fractions of females (Kir6.2: F, 1.24 +/- 0.07 vs. M, 1.02 +/- 0.06; SUR2: F, 3...
  60. ncbi Effect of expression of genes in the sphingolipid synthesis pathway on the biosynthesis of ceramide in Saccharomyces cerevisiae
    Se Kyung Kim
    Department of Biological Engineering, Inha University, Incheon 402 751, Korea
    J Microbiol Biotechnol 20:356-62. 2010
    ..we investigated the effect of the genes involved in the synthesis of ceramide, lcb1, lcb2, tsc10, lac1, lag1, and sur2 on ceramide production levels. The genes were cloned into pYES2 high copy number vectors. S...
  61. doi Expression of sulfonylurea receptors in rat taste buds
    Dian Xin Liu
    Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, No 23 Youzheng Street, Nangang District, Harbin 150001, Heilongjiang Province, China
    Acta Histochem 113:489-92. 2011
    ..staining was used to detect the expression and distribution of sulfonylurea receptor 1 (SUR1) or sulfonylurea receptor 2 (SUR2) in rat taste buds...
  62. doi Identification of five partial ABC genes in the liver of the Antarctic fish Trematomus bernacchii and sensitivity of ABCB1 and ABCC2 to Cd exposure
    Sara Zucchi
    Department of Environmental Sciences G Sarfatti, University of Siena, Via Mattioli 4, 53100 Siena, Italy
    Environ Pollut 158:2746-56. 2010
    ..Partial cDNA sequences of ABCB1, ABCC1, ABCC2, ABCC4 and ABCC9 were cloned from liver. Using RACE technology, 3.5 and 2.2 kb contigs were obtained for ABCB1 and ABCC2...
  63. ncbi Effects of metformin on rosiglitazone-induced cardiac hypertrophy in mice
    Hsiu Hao Lee
    Department of Internal Medicine, Zhongxing Branch of Taipei City Hospital, Taipei, Taiwan
    Biol Pharm Bull 33:1506-10. 2010
    ..Metformin inhibits obesity but has no effect in reducing myocardial hypertrophy caused by Rosiglitazone. Whether Metformin can reduce side effects of TZDs in humans warrants further study...
  64. pmc The mitochondrial bioenergetic phenotype for protection from cardiac ischemia in SUR2 mutant mice
    Nitin T Aggarwal
    Department of Medicine, University of Wisconsin, Madison, USA
    Am J Physiol Heart Circ Physiol 299:H1884-90. 2010
    The sulfonylurea receptor-2 (SUR2) is a subunit of ATP-sensitive potassium channels (K(ATP)) in heart. Mice with the SUR2 gene disrupted (SUR2m) are constitutively protected from ischemia-reperfusion (I/R) cardiac injury...
  65. pmc Sex differences in the contribution of ATP-sensitive K+ channels in trigeminal ganglia under an acute muscle pain condition
    K Niu
    Program in Neuroscience, Department of Neural and Pain Sciences, University of Maryland Baltimore School of Dentistry, 650 West Baltimore Street, Baltimore, MD 21201, USA
    Neuroscience 180:344-52. 2011
    ..1 and Kir6.2, as well as the regulatory sulfonylurea subunits, SUR1 and SUR2, were reliably detected in TG...
  66. doi Electrophysiological and functional effects of sphingosine-1-phosphate in mouse ventricular fibroblasts
    Najate Benamer
    UMR CNRS Université de Poitiers No 6187, Pôle Biologie Santé Bât B36, BP 633, 1 rue Georges Bonnet, 86022 Poitiers, France
    Biochem Biophys Res Commun 408:6-11. 2011
    ..We found that S1P activated SUR2/Kir6.1 channel and that this effect was sensitive to specific inhibition of the S1P receptor of type 3 (S1P3R)...
  67. doi A K(ATP) channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila
    K V Allebrandt
    Institute of Medical Psychology, Ludwig Maximilians University, Munich, Germany
    Mol Psychiatry 18:122-32. 2013
    ..We identified an intronic variant (rs11046205; P=3.99 × 10(-8)) in the ABCC9 gene that explains ≈5% of the variation in sleep duration...
  68. doi Hydroxylation state of fatty acid and long-chain base moieties of sphingolipid determine the sensitivity to growth inhibition due to AUR1 repression in Saccharomyces cerevisiae
    Motohiro Tani
    Department of Chemistry, Faculty of Sciences, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biochem Biophys Res Commun 417:673-8. 2012
    ..This diversity is created through the action of enzymes encoded by SUR2, SCS7, and as yet unidentified hydroxylation enzyme(s)...
  69. pmc Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes
    Matthieu Le Gallo
    Cancer Genetics Branch, National Human Genome Research Institute, US National Institutes of Health NIH, Bethesda, MD, USA
    Nat Genet 44:1310-5. 2012
    ..of somatic mutations in CHD4 (17%), EP300 (8%), ARID1A (6%), TSPYL2 (6%), FBXW7 (29%), SPOP (8%), MAP3K4 (6%) and ABCC9 (6%). Overall, 36...
  70. doi Cardiac K(ATP) channel alterations associated with acclimation to hypoxia in goldfish (Carassius auratus L.)
    John S Cameron
    Department of Biological Sciences, Wellesley College, Wellesley, MA 02481, USA
    Comp Biochem Physiol A Mol Integr Physiol 164:554-64. 2013
    ..enhanced, as was nitric oxide synthase (nos2) and the sulfonylurea receptor regulatory subunit (sur2, abcc9)...
  71. doi Quantification and in situ localisation of abcb1 and abcc9genes in toxicant-exposed sea urchin embryos
    Ivana Bosnjak
    Laboratory for Biology and Microbial Genetics, Department of Biochemical Engineering, Faculty of Food Technology and Biotechnology, Pierottijeva 6, Zagreb, Croatia
    Environ Sci Pollut Res Int 20:8600-11. 2013
    ..localisation of two ABC efflux transporters-P-glycoprotein (ABCB1/P-gp) and sulfonylurea-receptor-like protein (ABCC9/SUR-like)...
  72. pmc Identification of new adventitious rooting mutants amongst suppressors of the Arabidopsis thaliana superroot2 mutation
    Daniel Ioan Păcurar
    Umea Plant Science Centre, Department of Plant Physiology, Umea University, 90187 Umea, Sweden
    J Exp Bot 65:1605-18. 2014
    ..The Arabidopsis superroot2-1 (sur2-1) mutant overproduces auxin and, as a consequence, develops excessive adventitious roots in the hypocotyl...
  73. doi Phosphatidylinositol 4,5-biphosphate (PIP2) modulates syntaxin-1A binding to sulfonylurea receptor 2A to regulate cardiac ATP-sensitive potassium (KATP) channels
    Li Xie
    Department of Medicine, University of Toronto, Toronto, ON, Canada
    J Mol Cell Cardiol 75:100-10. 2014
    ....
  74. pmc Essential role of the zinc finger transcription factor Casz1 for mammalian cardiac morphogenesis and development
    Zhihui Liu
    From the Pediatric Oncology Branch and
    J Biol Chem 289:29801-16. 2014
    ..TNNI2, TNNT1, and CKM; contractile fiber gene ACTA1; and cardiac arrhythmia associated ion channel coding genes ABCC9 and CACNA1D. The transcriptional regulation of some of these genes by Casz1 was also found in cellular models...
  75. pmc ATP-sensitive potassium channels alleviate postoperative pain through JNK-dependent MCP-1 expression in spinal cord
    Xiang Zhu
    Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P R China
    Int J Mol Med 35:1257-65. 2015
    ..The results showed that KATP channel subunits Kir6.1, SUR1 and SUR2 were normally expressed in the spinal cord and significantly downregulated after SMIR...
  76. pmc Diazoxide Cardioprotection Is Independent of Adenosine Triphosphate-Sensitive Potassium Channel Kir6.1 Subunit in Response to Stress
    Matthew C Henn
    Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO
    J Am Coll Surg 221:319-25. 2015
    ..The Kir6.1 subunit can also contribute to K(ATP) channels in the heart, and we hypothesized that this subunit might play a role in myocyte volume regulation in response to stress...
  77. pmc Histone deacetylase inhibitors modulate KATP subunit transcription in HL-1 cardiomyocytes through effects on cholesterol homeostasis
    Naheed Fatima
    Department of Anatomy, Physiology and Genetics, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences Bethesda, MD, USA
    Front Pharmacol 6:168. 2015
    ..Two different HDIs, romidepsin and trichostatin A, caused ~20-fold increase in SUR2 (Abcc9) subunit mRNA expression in HL-1 cardiomyocytes...
  78. doi Localization of the ATP-sensitive K(+) channel regulatory subunits SUR2A and SUR2B in the rat brain
    Ming Zhou
    Department of Anatomy, Akita University Graduate School of Medicine and Faculty of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Neurosci Res 74:91-105. 2012
    ..b>SUR2 mRNA is widely expressed in many neurons and glial cells as revealed by in situ hybridization histochemistry...
  79. pmc A novel Sit4 phosphatase complex is involved in the response to ceramide stress in yeast
    Alexandra Woodacre
    Department of Genetics, University of Leicester, Leicester, UK
    Oxid Med Cell Longev 2013:129645. 2013
    ..a shift towards nonhydroxylated forms of long chain bases and sphingolipids, suggesting regulation of hydroxylase (SUR2) or ceramide synthase by Sit4p...
  80. pmc Glibenclamide binding to sulphonylurea receptor subtypes: dependence on adenine nucleotides
    Annette Hambrock
    Department of Pharmacology, Medical Faculty, University of Tubingen, Wilhelmstr 56, D 72074 Tubingen, Germany
    Br J Pharmacol 136:995-1004. 2002
    ..Here, we report on the negative allosteric modulation by MgATP and MgADP of glibenclamide binding to SUR1 and to SUR2 mutants with high glibenclamide affinity, SUR2A(Y1206S) and SUR2B(Y1206S)...
  81. ncbi Autosomal-dominant hypertension with type E brachydactyly is caused by rearrangement on the short arm of chromosome 12
    Sylvia Bahring
    Medical Faculty of the Charite, The Clinical Research Center, Franz Volhard Clinic and the Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Hypertension 43:471-6. 2004
    ..1, its regulator the sulfonyl urea receptor SUR2, and the phosphodiesterase PDE3A. We further studied 6 affected and 4 nonaffected persons...
  82. pmc Mutation of KCNJ8 in a patient with Cantú syndrome with unique vascular abnormalities - support for the role of K(ATP) channels in this condition
    Catherine A Brownstein
    Division of Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children s Hospital, Harvard Medical School, Boston, MA, USA Electronic address
    Eur J Med Genet 56:678-82. 2013
    ..Recently, the KATP gene ABCC9 (SUR2, NM_020297) has been associated with the multi-organ disorder Cantú syndrome or hypertrichotic ..
  83. ncbi The stereoenantiomers of a pinacidil analog open or close cloned ATP-sensitive K+ channels
    Ulf Lange
    Department of Pharmacology and Toxicology, University of Tubingen, Wilhelmstrasse 56, D 72074 Tubingen, Germany
    J Biol Chem 277:40196-205. 2002
    ..2/SUR channels. In patch clamp experiments, the R-enantiomer (PNU-96293) inhibited Kir6.2/SUR2 channels (IC(50) approximately 50 nm in the whole cell configuration), whereas the S-enantiomer (PNU-96179) was a ..
  84. pmc Activation domain-mediator interactions promote transcription preinitiation complex assembly on promoter DNA
    Greg T Cantin
    Molecular Biology Institute and Department of Microbiology, Immunology and Molecular Genetics, 611 Charles E Young Drive East, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 100:12003-8. 2003
    ..that the major adenovirus E1A and mitogen-activated protein kinase-phosphorylated Elk1 activation domains bind to Sur2 uniquely among the metazoan mediator subunits and the development of transcriptionally active nuclear extracts from ..
  85. ncbi Cloning and functional characterization of the SUR2/SYR2 gene encoding sphinganine hydroxylase in Pichia ciferrii
    Jung Hoon Bae
    Laboratory of Microbial Functions, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon 305 333, Korea
    Yeast 21:437-43. 2004
    Saccharomyces cerevisiae sphinganine C4-hydroxylase encoded by the SUR2 gene catalyses the conversion of sphinganine to phytosphingosine. We isolated the SUR2 gene from Pichia ciferrii using nucleotide sequence homology to S...
  86. doi A-62176, a potent topoisomerase inhibitor, inhibits the expression of human epidermal growth factor receptor 2
    Hye Lin Kim
    College of Pharmacy, Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Republic of Korea
    Cancer Lett 325:72-9. 2012
    ..suggest that A-62176 inhibits the interaction between the ESX, an ets transcription factor, and its co-activator Sur2, leading to the attenuation of HER2-mediated phosphorylation of MAPK/Akt...
  87. pmc Promoter DNA methylation regulates murine SUR1 (Abcc8) and SUR2 (Abcc9) expression in HL-1 cardiomyocytes
    Naheed Fatima
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, F Edward Hebert School of Medicine, Bethesda, Maryland, United States of America
    PLoS ONE 7:e41533. 2012
    Two mammalian genes encode the SURx (SUR1, Abcc8 and SUR2, Abcc9) subunits that combine with Kir6.2 (Kcnj11) subunits to form the ATP-sensitive potassium (KATP) channel in cardiac myocytes...
  88. pmc CRS-MIS in Candida glabrata: sphingolipids modulate echinocandin-Fks interaction
    Kelley R Healey
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Mol Microbiol 86:303-13. 2012
    ..DHS) and phytosphingosine (PHS) levels, and consistent with this sequencing revealed fen1, sur4, ifa38 and sur2 mutations. Moreover, exogenous DHS or PHS conferred a CRS-MIS phenotype on wild-type C. glabrata...
  89. pmc Fibroblast KATP currents modulate myocyte electrophysiology in infarcted hearts
    Najate Benamer
    Leon H Charney Division of Cardiology, New York University School of Medicine, New York, New York 10016, USA
    Am J Physiol Heart Circ Physiol 304:H1231-9. 2013
    ..4 ± 7.5 pA/pF at 50 mV) in sMI-Fb that was inhibited with 10 μmol/l glibenclamide. Kir6.2 and SUR2 transcript levels were elevated in sMI-Fb. Treatment with Kir6...
  90. doi Expression and purification of a soluble ESX-binding core domain of SUR2
    Kyung Hwa Jeon
    College of Pharmacy, Ewha Womans University, Seoul, Korea
    Prep Biochem Biotechnol 43:364-75. 2013
    For HER2 overexpression, the ESX transcription factor must interact with both the HER2 promoter and Sur2, a subunit of human mediator complex, using its Ets domain and transactivation domain, respectively...
  91. pmc Hypotension due to Kir6.1 gain-of-function in vascular smooth muscle
    Anlong Li
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO
    J Am Heart Assoc 2:e000365. 2013
    KATP channels, assembled from pore-forming (Kir6.1 or Kir6.2) and regulatory (SUR1 or SUR2) subunits, link metabolism to excitability. Loss of Kir6.2 results in hypoglycemia and hyperinsulinemia, whereas loss of Kir6...
  92. ncbi Yeast mutants affected in viability upon starvation have a modified phospholipid composition
    L Desfarges
    Laboratoire de Genetique, Talence, France
    Yeast 9:267-77. 1993
    ..Ten mutants were obtained, ranged amongst four complementation groups, named SUR1, SUR2, SUR3 and SUR4...
  93. ncbi SYR2, a gene necessary for syringomycin growth inhibition of Saccharomyces cerevisiae
    P Cliften
    Department of Biology and Program in Molecular Biology, Utah State University, Logan 84322 5305, USA
    Microbiology 142:477-84. 1996
    ..SYR2 was identical to SUR2, which is involved in survival during nutritional starvation...
  94. pmc SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandil
    T Shindo
    Department of Pharmacology II, Faculty of Medicine, Osaka University, Suita, Japan
    Br J Pharmacol 124:985-91. 1998
    ....
  95. ncbi The properties of the Kir6.1-6.2 tandem channel co-expressed with SUR2A
    Y Kono
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Pflugers Arch 440:692-8. 2000
    ..2 to MgATP (IC50=95.5+/-49.6 microM versus 18.9+/-5.0 microM). These results suggest that Kir6.1 and Kir6.2 are endowed with the potential to form a heteromeric KATP channel, which has a low sensitivity to MgATP...
  96. ncbi Molecular characterization of human SUR2-containing K(ATP) channels
    R Davis-Taber
    Neurological and Urological Diseases Research, Dept 47C, APgA, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Gene 256:261-70. 2000
    The distribution of human sulfonylurea receptor-2 (SUR2)-containing K(ATP) channels was investigated using reverse transcriptase-polymerase chain reaction (RT-PCR)...
  97. pmc Accumulation of phosphorylated sphingoid long chain bases results in cell growth inhibition in Saccharomyces cerevisiae
    S Kim
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Genetics 156:1519-29. 2000
    ..the biological roles of these molecules, we created disruption mutants for LCB4, LCB5, DPL1, YSR2, YSR3, and SUR2. LCB4 and LCB5 encode kinases that phosphorylate long chain bases...
  98. pmc Susceptibility of ATP-sensitive K+ channels to cell stress through mediation of phosphoinositides as examined by photoirradiation
    Z Fan
    The Department of Physiology, University of Tennessee, College of Medicine, Memphis, TN 38163, USA
    J Physiol 529:707-21. 2000
    ..were recorded from cell-attached and inside-out patches of rat ventricular myocytes and COS-1 cells coexpressing SUR2 and Kir6.2. KATP channel activity increased within < 1 min upon irradiation...
  99. pmc Disruption of Sur2-containing K(ATP) channels enhances insulin-stimulated glucose uptake in skeletal muscle
    W A Chutkow
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 98:11760-4. 2001
    ..used a gene-targeting strategy to generate mice with a disruption in the muscle-specific K(ATP) regulatory subunit, SUR2. Insertional mutagenesis of the Sur2 locus generated homozygous null (Sur2(-/-)) mice and heterozygote (Sur2(+/-)) ..
  100. ncbi Putative subunits of the rat mesangial KATP: a type 2B sulfonylurea receptor and an inwardly rectifying K+ channel
    Balazs Szamosfalvi
    Department of Medicine, Division of Nephrology and Hypertension, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Kidney Int 61:1739-49. 2002
    ..Because these responses likely resulted from the binding of sulfonylurea to a mesangial SUR2, we subsequently documented [3H]-glibenclamide binding to MC and the gene expression of several mesangial SUR2 ..
  101. ncbi Novel insulin/GIP co-producing cell lines provide unexpected insights into Gut K-cell function in vivo
    Erin B Ramshur
    Department of Internal Medicine, Division of Metabolism, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Physiol 192:339-50. 2002
    ..The K-cell lines also express relatively low levels of Kir 6.1, Kir 6.2, SUR1, and SUR2 suggesting secretion is independent of K(ATP) channels...

Research Grants21

  1. Molecular Regulation of Cardiac KATP Channels in Ischemia
    Jonathan C Makielski; Fiscal Year: 2013
    ..The sulfonylurea receptor subunit SUR2 regulates pharmacology and nucleotide interactions for sKATP, but the role of SUR2 in mKATP is unknown...
  2. Genetic Markers of GIK Effect in Acute Coronary Syndrome in the IMMEDIATE Trial
    Inga Peter; Fiscal Year: 2012
    ..and IDE), fatty acid metabolism regulation (PRKAA2, PPARA, and PPARG), and potassium channel activity (KCNJ11 and ABCC9) in the heart will be associated with the immediate and long-term response to GIK therapy administered in the ..
  3. Molecular Regulation of Cardiac KATP Channels in Ischemia
    Jonathan C Makielski; Fiscal Year: 2012
    ..The sulfonylurea receptor subunit SUR2 regulates pharmacology and nucleotide interactions for sKATP, but the role of SUR2 in mKATP is unknown...
  4. Redox Regulation of ATP Sensitive Potassium Channels
    Li Bao; Fiscal Year: 2012
    ..that thioredoxin-2 and the cytosolic isoform thioredoxin 1 also direct interact with full-length SUR1 or SUR2 subunit in a heterologous expression system...
  5. The Role of Sulfonylurea Receptor 2 Splice Variants in Myocardial Function
    John P Fahrenbach; Fiscal Year: 2011
    ..KATP channels are also the target of sulfonylurea drugs used to treat diabetes. The sulfonylurea receptor 2 (SUR2) is the regulatory subunit of cardiac KATP channel and directly binds to ADP...
  6. Echinocandin Reduced/Increased Susceptibility: Mechanism
    Santosh Kumar Katiyar; Fiscal Year: 2013
    ..Based on these data specific genes were sequenced and, indeed, mutations identified in SUR2, FEN1, SUR4, and IFA38 CRS-MIS is not limited to C...
  7. Mechanisms underlie inverse gender discrepancy in ischemic protection
    Nian Qing Shi; Fiscal Year: 2010
    ..HEALTH RELEVANCE: The proposed research will employ KATP channel mutant mice that are defective in the sulfonylurea receptor 2 (SUR2) to evaluate gender difference in ischemic protection, regulation of estrogen in sarcolemmal and ..
  8. BRUCE A BEUTLER; Fiscal Year: 2016
    ..Among these are channel proteins (SLC15A4;KCNJ8/SUR2), transcription factors (IKB;AKIRIN2), proteins concerned with membrane trafficking or organellar mobility (AP3B1;..
  9. Development of HTS Assay:PK(ATP)FLIPR Channels (RMI)
    Xinmin Xie; Fiscal Year: 2005
    ..2 subunits) for primary screening and against the muscle form (e. g. , SUR2/Kir6...
  10. Colin G Nichols; Fiscal Year: 2016
    ..Previous efforts on this project have demonstrated that both SUR1 and SUR2 genes are expressed in the heart, with spatial and pathological variability in different regions...
  11. SUR Transmembrane Domain in K(ATP) Channel Function
    Robert Harvey; Fiscal Year: 2006
    ..g. SUR1, SUR2), and (ii) an Inwardly rectifying potassium (j about) channel subunit (Kir6; e.g. Kir6.1, Kir6.2)...
  12. Sulfonylurea KATP channels in vascular spasm
    Elizabeth McNally; Fiscal Year: 2009
    Potassium ATP (KATP) channels are composed of a sulfonylurea subunit, SUR1 or SUR2, and a pore forming potassium channel, Kir6.1 or Kir6.2...
  13. Role of Kir6.1 subunits of K+ channels in heart
    WILLIAM COETZEE; Fiscal Year: 2004
    ..1 and Kir6.2) - both are highly expressed in heart. Cardiac KATP channels are believed to consist of Kir6.2/SUR2 complexes. However, the role of Kir6.1 is unknown...
  14. Metabolism-excitation coupling in the heart
    Colin Nichols; Fiscal Year: 2005
    ..The work will provide information that will ultimately underlie the development of rational therapies for the treatment of cardiac ischemia and arrhythmias. ..
  15. Identification of Disease Genes for Atrial Fibrillation
    Timothy Olson; Fiscal Year: 2009
    ..The long-term objectives of this work are to gain new insights into molecular mechanisms of arrhythmogenesis and to improve prediction, prevention, and treatment of AF. ..
  16. Reactive astrocytes from gliotic capsule
    J Marc Simard; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  17. CEREBROVASCULAR ION CHANNELS IN HYPERTENSION
    J Marc Simard; Fiscal Year: 2007
    ..abstract_text> ..
  18. MOLECULAR BIOLOGY AND PATHOGENESIS OF MOUSE ADENOVIRUS
    KATHERINE SPINDLER; Fiscal Year: 2007
    ..These studies will further our knowledge of adenovirus biology, host immune mechanisms and viral immune evasion. ..
  19. Cloning a major gene for mouse adenovirus susceptibility
    Katherine R Spindler; Fiscal Year: 2010
    ..The project is expected to identify a previously undescribed intractiorT^ieT^eerrK6sfiTrTrmrne res immune evasion, thus increasing our understanding of viral infections and mechanisms of host response to pathogens. ~ ..
  20. PATHOPHYSIOLOGY OF NICOTINE IN CEREBRAL BLOOD VESSELS
    J Simard; Fiscal Year: 2004
    ....