ABCB1

Summary

Gene Symbol: ABCB1
Description: ATP binding cassette subfamily B member 1
Alias: ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1, multidrug resistance protein 1, ATP-binding cassette, sub-family B (MDR/TAP), member 1, P glycoprotein, P-glycoprotein 1, colchicin sensitivity, doxorubicin resistance
Species: human

Top Publications

  1. ncbi A "silent" polymorphism in the MDR1 gene changes substrate specificity
    Chava Kimchi-Sarfaty
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Science 315:525-8. 2007
  2. pmc Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
    S Hoffmeyer
    Epidauros Biotechnology, Pharmacogenetics Laboratory, Am Neuland 1, D 82347 Bernried, Germany
    Proc Natl Acad Sci U S A 97:3473-8. 2000
  3. ncbi Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief
    D Campa
    Department of Biology, University of Pisa, Pisa, Italy
    Clin Pharmacol Ther 83:559-66. 2008
  4. ncbi Allelic variations of the multidrug resistance gene determine susceptibility and disease behavior in ulcerative colitis
    Gwo Tzer Ho
    Gastrointestinal Unit, Western General Hospital, Edinburgh, Scotland, UK
    Gastroenterology 128:288-96. 2005
  5. pmc Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study
    Vibeke Andersen
    Medical Department, Viborg Regional Hospital, DK 8800 Viborg, Denmark
    BMC Cancer 9:407. 2009
  6. ncbi Isolation and expression of a complementary DNA that confers multidrug resistance
    P Gros
    Nature 323:728-31. 1986
  7. pmc Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics
    Federico Innocenti
    The University of Chicago, Chicago, IL 60637, USA
    J Clin Oncol 27:2604-14. 2009
  8. pmc Wnt/β-catenin pathway regulates ABCB1 transcription in chronic myeloid leukemia
    Stephany Corrêa
    Divisão de Laboratórios CEMO, INCA, Rio de Janeiro, Brazil
    BMC Cancer 12:303. 2012
  9. ncbi P-glycoprotein inhibition as a therapeutic approach for overcoming multidrug resistance in cancer: current status and future perspectives
    Ziyad Binkhathlan
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
    Curr Cancer Drug Targets 13:326-46. 2013
  10. pmc Characterization of the human MDR1 gene
    Miklos Bodor
    Department of Pharmaceutics, University of Washington, Seattle, Washington 98195 7610, USA
    AAPS J 7:E1-5. 2005

Research Grants

Detail Information

Publications401 found, 100 shown here

  1. ncbi A "silent" polymorphism in the MDR1 gene changes substrate specificity
    Chava Kimchi-Sarfaty
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Science 315:525-8. 2007
    ..We report that a synonymous SNP in the Multidrug Resistance 1 (MDR1) gene, part of a haplotype previously linked to altered function of the MDR1 gene product P-glycoprotein (P-gp), ..
  2. pmc Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
    S Hoffmeyer
    Epidauros Biotechnology, Pharmacogenetics Laboratory, Am Neuland 1, D 82347 Bernried, Germany
    Proc Natl Acad Sci U S A 97:3473-8. 2000
    ..Homozygosity for this variant was observed in 24% of our sample population (n = 188). This polymorphism is expected to affect the absorption and tissue concentrations of numerous other substrates of MDR-1...
  3. ncbi Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief
    D Campa
    Department of Biology, University of Pisa, Pisa, Italy
    Clin Pharmacol Ther 83:559-66. 2008
    ..We focused on two such genes: ABCB1/MDR1, a major determinant of morphine bioavailability, and OPRM1, which encodes for the mu-opioid receptor, the ..
  4. ncbi Allelic variations of the multidrug resistance gene determine susceptibility and disease behavior in ulcerative colitis
    Gwo Tzer Ho
    Gastrointestinal Unit, Western General Hospital, Edinburgh, Scotland, UK
    Gastroenterology 128:288-96. 2005
    The MDR1 gene encodes P-glycoprotein 170, an efflux transporter that is highly expressed in intestinal epithelial cells...
  5. pmc Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study
    Vibeke Andersen
    Medical Department, Viborg Regional Hospital, DK 8800 Viborg, Denmark
    BMC Cancer 9:407. 2009
    The xenobiotic transporters, Multidrug Resistance 1 (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) may restrict intestinal absorption of various carcinogens, including heterocyclic amines (HCA) and polycyclic aromatic ..
  6. ncbi Isolation and expression of a complementary DNA that confers multidrug resistance
    P Gros
    Nature 323:728-31. 1986
    ..resistance are frequently associated with amplification and overexpression of a small group of genes termed mdr or gp170. Direct evaluation of the role of these genes in multidrug resistance has awaited the isolation of a member of ..
  7. pmc Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics
    Federico Innocenti
    The University of Chicago, Chicago, IL 60637, USA
    J Clin Oncol 27:2604-14. 2009
    ..We aim to identify genetic variation, in addition to the UGT1A1*28 polymorphism, that can explain the variability in irinotecan (CPT-11) pharmacokinetics and neutropenia in cancer patients...
  8. pmc Wnt/β-catenin pathway regulates ABCB1 transcription in chronic myeloid leukemia
    Stephany Corrêa
    Divisão de Laboratórios CEMO, INCA, Rio de Janeiro, Brazil
    BMC Cancer 12:303. 2012
    ..This resistance has been associated with the overexpression of ABCB1, which gives rise to the multidrug resistance (MDR) phenomenon...
  9. ncbi P-glycoprotein inhibition as a therapeutic approach for overcoming multidrug resistance in cancer: current status and future perspectives
    Ziyad Binkhathlan
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
    Curr Cancer Drug Targets 13:326-46. 2013
    ..This review will provide an overview and update on the status of P-gp inhibition approaches and the role of drug delivery systems in overcoming P-gp mediated MDR...
  10. pmc Characterization of the human MDR1 gene
    Miklos Bodor
    Department of Pharmaceutics, University of Washington, Seattle, Washington 98195 7610, USA
    AAPS J 7:E1-5. 2005
    ..efflux transporter that protects the body from environmental toxins and xenobiotics, is encoded by the human MDR1 gene. Human MDR1 is located on chromosomal region 7q21...
  11. doi MDR1 C3435T polymorphism and cancer risk: a meta-analysis based on 39 case-control studies
    Xiaojing Sheng
    State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, China
    Mol Biol Rep 39:7237-49. 2012
    Multidrug resistance 1 (MDR1) gene encodes the ATP-dependent cellular efflux pump P-glycoprotein (P-gp) which efflux of a variety of substances across the membrane...
  12. pmc Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids
    Radha Ramesh
    Tempero pharmaceuticals, Inc, 200 Technology Square, Suite 602, Cambridge, MA 02139
    J Exp Med 211:89-104. 2014
    ..cells that transiently express c-Kit and stably express P-glycoprotein (P-gp)/multi-drug resistance type 1 (MDR1)...
  13. ncbi Modulation of multidrug resistance P-glycoprotein 1 (ABCB1) expression in human heart by hereditary polymorphisms
    Konrad Meissner
    Peter Holtz Research Center of Pharmacology and Experimental Therapeutics, Ernst Moritz Arndt University Greifswald, Germany
    Pharmacogenetics 14:381-5. 2004
    Variable expression of the ABC-type multidrug resistance membrane protein P-glycoprotein (P-gp, MDR1, ABCB1) in human heart is a potential modulator of drug effects or drug-induced cardiotoxicity...
  14. ncbi Influence of polymorphisms of ABCB1 and ABCC2 on mRNA and protein expression in normal and cancerous kidney cortex
    S Haenisch
    Institute of Pharmacology, University Hospital Schleswig Holstein, Kiel, Germany
    Pharmacogenomics J 7:56-65. 2007
    There is increasing evidence that polymorphisms of the adenosine 5' triphosphate membrane transporters ABCB1 (P-glycoprotein, MDR1) may affect expression and function, whereas less information is available about the impact of ABCC2 (..
  15. doi Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression
    Manfred Uhr
    Max Planck Institute of Psychiatry, Kraepelinstr 10, 80804 Munich, Germany
    Neuron 57:203-9. 2008
    ..system depends on its ability to pass the blood-brain barrier, which is regulated by transporter molecules such as ABCB1 (MDR1)...
  16. doi Effects of CYP2C19, MDR1, and interleukin 1-B gene variants on the eradication rate of Helicobacter pylori infection by triple therapy with pantoprazole, amoxicillin, and metronidazole
    Barbara Gawronska-Szklarz
    Department of Pharmacology, Pomeranian Medical University, Powstancow Wlkp 72, 70 111, Szczecin, Poland
    Eur J Clin Pharmacol 66:681-7. 2010
    ..Aim of the present study was to evaluate an association of CYP2C19, MDR1, and IL-1B polymorphisms with the eradication rate of H...
  17. pmc Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1
    S Sengupta
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 1079, USA
    Oncogene 30:482-93. 2011
    ..with Y-box-binding protein 1 (YB-1), and acts as its coactivator for the expression of multidrug resistance gene MDR1, thereby causing drug resistance...
  18. doi A MDR1 (ABCB1) gene single nucleotide polymorphism predicts outcome of temozolomide treatment in glioblastoma patients
    M Schaich
    Department of Medicine I, University Hospital C G Carus, Dresden, Germany
    Ann Oncol 20:175-81. 2009
    ..We aimed to confirm first that temozolomide is a target for the multidrug resistance transporter MDR1/ABCB1 and second to investigate whether genetic variants of the MDR1 gene are associated with the survival of ..
  19. ncbi A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression
    R L Roberts
    Department of Pathology, Christchurch School of Medicine, Christchurch, New Zealand
    Pharmacogenomics J 2:191-6. 2002
    The multi-drug resistance gene ABCB1 (or MDR1) encodes a P-glycoprotein (P-gp) that regulates passage of many substances across the blood-brain barrier...
  20. ncbi ABCB1 and cytochrome P450 genotypes and phenotypes: influence on methadone plasma levels and response to treatment
    Severine Crettol
    Unite de Biochimie et Psychopharmacologie Clinique, Centre de Neurosciences Psychiatriques, Département de Psychiatrie Centre Hospitalier Universitaire Vaudois, Hôpital de Cery, Prilly Lausanne, Switzerland
    Clin Pharmacol Ther 80:668-81. 2006
    ..The in vivo implication of various cytochrome P450 (CYP) isoforms and of P-glycoprotein on methadone kinetics is unclear. We aimed to thoroughly examine the genetic factors influencing methadone kinetics and response to treatment...
  21. ncbi Imatinib disposition and ABCB1 (MDR1, P-glycoprotein) genotype
    H Gurney
    Department of Medical Oncology, Westmead Hospital Sydney West Area Health Service, Westmead, New South Wales, Australia
    Clin Pharmacol Ther 82:33-40. 2007
    ..1 and at steady-state were compared with elimination phenotype and single-nucleotide polymorphisms of CYP3A5 and ABCB1. A fivefold variation in estimated imatinib clearance (CL/F) was present on day 1 and mean CL/F had fallen by 26% ..
  22. ncbi P-glycoprotein models of the apo and ATP-bound states based on homology with Sav1866 and MalK
    Megan L O'Mara
    Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta, Canada
    FEBS Lett 581:4217-22. 2007
    ..These conformations (see supplementary material) may characterize some of the major steps in the nucleotide catalytic cycle...
  23. pmc ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence
    Orna Levran
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Hum Mol Genet 17:2219-27. 2008
    ..Methadone is a substrate of the transporter P-glycoprotein (P-gp) 170 that is encoded by the ABCB1 (MDR1) gene. Thus, P-gp variants may play a role in methadone absorption and distribution...
  24. pmc Processing mutations disrupt interactions between the nucleotide binding and transmembrane domains of P-glycoprotein and the cystic fibrosis transmembrane conductance regulator (CFTR)
    Tip W Loo
    Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 283:28190-7. 2008
    P-glycoprotein (P-gp, ABCB1) is an ATP-dependent drug pump. Each of its two homologous halves contains a transmembrane domain (TMD) that has six transmembrane (TM) segments and a nucleotide-binding domain (NBD)...
  25. doi Multidrug resistance gene (MDR1) polymorphisms correlate with imatinib response in chronic myeloid leukemia
    Ling Na Ni
    Department of Hematology, Jiangsu Province Hospital, The First Affiliated Nanjing Medical University Hospital, Nanjing Medical University, 300 Guangzhou Rd, 210029 Nanjing, China
    Med Oncol 28:265-9. 2011
    The human multidrug resistance gene (MDR1, ABCB1) codes for P-glycoprotein (P-gp) that affects the pharmacokinetics of many drugs. MDR1 single nucleotide polymorphisms (SNPs) are associated with drug clearance...
  26. doi MDR-1 gene polymorphisms in steroid-responsive versus steroid-resistant nephrotic syndrome in children
    Tabrez Jafar
    Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Nephrol Dial Transplant 26:3968-74. 2011
    ....
  27. pmc ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas
    Sharon E Johnatty
    Queensland Institute of Medical Research, Brisbane, Australia
    Gynecol Oncol 131:8-14. 2013
    b>ABCB1 encodes the multi-drug efflux pump P-glycoprotein (P-gp) and has been implicated in multi-drug resistance...
  28. ncbi ABCB1 C3435T and G2677T/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation
    Takeshi Asano
    Department of Orthopaedic Surgery, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, Japan
    Pharmacogenetics 13:675-82. 2003
    ..and investigated the relationship between single nucleotide polymorphisms in the multidrug resistance gene 1 (ABCB1, MDR1) encoding P-gp and ONF. Subjects comprised 136 patients receiving kidney transplantation...
  29. pmc Up-regulation of MDR1 and induction of doxorubicin resistance by histone deacetylase inhibitor depsipeptide (FK228) and ATRA in acute promyelocytic leukemia cells
    Yoko Tabe
    Section of Molecular Hematology and Therapy, Department of Blood and Marrow Transplantation, Unit 448, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Blood 107:1546-54. 2006
    The multidrug resistance 1 (MDR1) gene product P-glycoprotein (P-gp) is frequently implicated in cross-resistance of tumors to chemotherapeutic drugs...
  30. doi Multidrug resistance gene (MDR1) polymorphisms are associated with major molecular responses to standard-dose imatinib in chronic myeloid leukemia
    Stéphanie Dulucq
    Laboratoire Hématopoïèse Leucémique et Cible Thérapeutique, Universite Victor Segalen Bordeaux 2, Inserm U876, Bordeaux, France
    Blood 112:2024-7. 2008
    ..Imatinib has been reported to be a substrate of the P-glycoprotein pump. In the current study, we focused on the ABCB1 (MDR1) genotype...
  31. doi ABCB1 gene polymorphisms and haplotype analysis in colorectal cancer
    Mariusz Panczyk
    Department of Pharmaceutical Biochemistry, Laboratory of Molecular Biology and Pharmacogenomics, Medical University of Lodz, Lodz, Poland
    Int J Colorectal Dis 24:895-905. 2009
    ..aim of this study was to determine the significance of three most common single-nucleotide polymorphisms (SNPs) of ABCB1 gene in the development of colorectal cancer and to estimate the influence of these SNPs to surviving patients' ..
  32. doi Multidrug resistance 1 (MDR1) gene polymorphisms in childhood drug-resistant epilepsy
    Asude Alpman
    Ege University Faculty of Medicine, Department of Medical Genetics, Izmir, Turkey
    J Child Neurol 25:1485-90. 2010
    ..Multidrug resistance 1 (MDR1) gene could play a role in drug resistance in epilepsy...
  33. doi Predisposition to epilepsy--does the ABCB1 gene play a role?
    Laila Nurmohamed
    Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Epilepsia 51:1882-5. 2010
    We performed a meta-analysis to evaluate the association between ABCB1 C3435T polymorphisms and the prevalence of epilepsy, including all relevant human studies (until June 2009), in which patients with or without epilepsy had undergone ..
  34. pmc Polymorphisms in the multiple drug resistance protein 1 and in P-glycoprotein 1 are associated with time to event outcomes in patients with advanced multiple myeloma treated with bortezomib and pegylated liposomal doxorubicin
    Gabriele Buda
    Department of Oncology, Transplants and Advanced Technologies, University of Pisa, Pisa, Italy
    Ann Hematol 89:1133-40. 2010
    Single nucleotide polymorphisms (SNPs) in the multiple drug resistance protein 1 (MRP1) and P-glycoprotein 1 (MDR1) genes modulate their ability to mediate drug resistance...
  35. ncbi Associations of allelic variants of the multidrug resistance gene (ABCB1 or MDR1) and inflammatory bowel disease and their effects on disease behavior: a case-control and meta-analysis study
    Clive M Onnie
    Department of Medical and Molecular Genetics, King s College London School of Medicine, Guy s Hospital, UK
    Inflamm Bowel Dis 12:263-71. 2006
    Allelic variants of the ATP-binding cassette, subfamily B member 1 (ABCB1), also known as the multidrug resistance gene (MDR1) that encodes the membrane-bound efflux transporter P-glycoprotein 170 (PGP-170), have been associated with ..
  36. ncbi ATP-binding cassette transporter ABCG2 (BCRP) and ABCB1 (MDR1) variants are not associated with disease susceptibility, disease phenotype response to medical therapy or need for surgeryin Hungarian patients with inflammatory bowel diseases
    Simon Fischer
    1st Department of Medicine, Semmelweis University, Budapest, Hungary
    Scand J Gastroenterol 42:726-33. 2007
    MDR1 (ABCB1), a member of the ATP-binding cassette (ABC) transporters, is an attractive candidate gene for the pathogenesis of inflammatory bowel diseases (IBD) and perhaps for response to therapy...
  37. ncbi Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy
    Mike Ufer
    University Hospital Schleswig Holstein, Germany
    Pharmacogenet Genomics 19:353-62. 2009
    ..non-response to antiepileptic pharmacotherapy with the frequency of variant alleles in the drug transporter genes ABCB1 and ABCC2 or in the CYP2C locus in young patients with epilepsy and an independent cohort of adults with drug-..
  38. doi Genetic factors associated with drug-resistance of epilepsy: relevance of stratification by patient age and aetiology of epilepsy
    M Blanca Sánchez
    Clinical Pharmacology Service, Marques de Valdecilla University Hospital, University of Cantabria School of Medicine, Avenida de Valdecilla S N, 39008 Santander, Spain
    Seizure 19:93-101. 2010
    ..association between polymorphisms related to antiepileptic drug metabolism (CYP2C9, CYP2C19, and UGT), transport (ABCB1), and targets (SCN1A) both in a crude analysis and after adjusting by clinical factors associated with drug-..
  39. ncbi Digoxin pharmacokinetics and MDR1 genetic polymorphisms
    Celine Verstuyft
    Department of Pharmacology, Saint Antoine Hospital, 184 rue du Faubourg Saint Antoine, 75012, Paris, France
    Eur J Clin Pharmacol 58:809-12. 2003
    The effect of MDR1 C3435T single nucleotide polymorphism (SNP) in exon 26 on digoxin pharmacokinetics has recently been challenged. OBJECTIVE...
  40. ncbi P-glycoprotein: from genomics to mechanism
    Suresh V Ambudkar
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute NIH, 37 Convent Drive, Building 37, Room 1A 09, Bethesda, MD 20892 4254, USA
    Oncogene 22:7468-85. 2003
    ..The first of these to be identified was P-glycoprotein (P-gp), the product of the human MDR1 gene, localized to chromosome 7q21. P-gp is a member of the large ATP-binding cassette (ABC) family of proteins...
  41. ncbi Variable expression of P-glycoprotein in the human placenta and its association with mutations of the multidrug resistance 1 gene (MDR1, ABCB1)
    Monika Hitzl
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
    Pharmacogenetics 14:309-18. 2004
    The MDR1 gene product P-glycoprotein in the human placenta is important for protecting the fetus from unintended, harmful drug exposure, but also for limiting the access of therapeutic drugs to the fetus after maternal drug intake...
  42. ncbi Pharmacogenomics of MDR1/ABCB1 gene: the influence on risk and clinical outcome of haematological malignancies
    Krzysztof Jamroziak
    Department of Haematology, Medical University of Lodz, Poland
    Hematology 9:91-105. 2004
    ..The multi-drug resistance-1, MDR1 (ABCB1) gene belongs to ATP-binding cassette (ABC) family and encodes for membrane transporter P-glycoprotein (P-gp)...
  43. ncbi Monocyte chemoattractant protein-1 (MCP-1) gene polymorphism and risk of Alzheimer's disease in Italians
    Roberto Pola
    Laboratory of Vascular Biology and Genetics, Department of Medicine, A Gemelli University Hospital, Università Cattolica del Sacro Cuore School of Medicine, Rome, Italy
    Exp Gerontol 39:1249-52. 2004
    ....
  44. ncbi Consequences of genetic polymorphisms for sirolimus requirements after renal transplant in patients on primary sirolimus therapy
    Dany Anglicheau
    Unité INSERM UMR S490, Molecular Toxicology, Centre Universitaire des Saints Peres, Universite Rene Descartes, Paris, France
    Am J Transplant 5:595-603. 2005
    Sirolimus (SRL) is a substrate for cytochromes P-450 3A and P-glycoprotein, the product of the MDR1 gene...
  45. ncbi The association of common SNPs and haplotypes in the CETP and MDR1 genes with lipids response to fluvastatin in familial hypercholesterolemia
    Dani Bercovich
    The Laboratory for Molecular Genetics and Pharmacogenetics, Migal Galilee Technology Center, Kiryat Shmona, Israel
    Atherosclerosis 185:97-107. 2006
    To examine whether genetic polymorphisms in the cholesteryl-ester transfer protein (CETP) and the P-glycoprotein drug transporter (MDR1), are associated with variable lipid response to fluvastatin.
  46. ncbi Genetic polymorphisms in the ABCB1 gene and the effects of fentanyl in Koreans
    H J Park
    Department of Anesthesiology, Inha University Hospital, Inha University, Incheon, South Korea
    Clin Pharmacol Ther 81:539-46. 2007
    P-glycoprotein (PGP) is a polymorphic transporter encoded by the ABCB1 gene that contributes to the access of xenobiotics into the brain...
  47. ncbi Multi-drug resistance gene-1 (MDR-1) haplotypes and the CYP3A5*1 genotype have no influence on ciclosporin dose requirements as assessed by C0 or C2 measurements
    Salim Fredericks
    Analytical Unit, Cardiac and Vascular Science, St George s University of London, London, UK
    Clin Transplant 21:252-7. 2007
    ..MDR-1 SNPs and haplotypes and also CYP3A5*1 genotype, do not appear to have a major influence on ciclosporin pharmacokinetics...
  48. ncbi Regulatory polymorphisms of multidrug resistance 1 (MDR1) gene are associated with the development of childhood acute lymphoblastic leukemia
    Hiroyoshi Hattori
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Leuk Res 31:1633-40. 2007
    The aim of this study is to determine whether the polymorphisms of the MDR1 gene are associated with the development of childhood acute lymphoblastic leukemia (ALL)...
  49. ncbi Promoter polymorphisms and allelic imbalance in ABCB1 expression
    Corinne Loeuillet
    Institute of Microbiology, University Hospital, Lausanne, Switzerland
    Pharmacogenet Genomics 17:951-9. 2007
    The ABCB1 (MDR1) gene, encoding the transporter P-glycoprotein, is known to act on a broad range of prescription medicines. For this reason a large number of studies have assessed the functional consequences of variation in this gene...
  50. pmc Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1
    Ranajoy Chattopadhyay
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 1079, USA
    Mol Cell Biol 28:7066-80. 2008
    ..1 (YB-1) and enhances its binding to the Y-box element, leading to the activation of the multidrug resistance gene MDR1. The enhanced MDR1 level due to the ectopic expression of wild-type APE1 but not of its nonacetylable mutant ..
  51. doi Human P-glycoprotein is active when the two halves are clamped together in the closed conformation
    Tip W Loo
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Biochem Biophys Res Commun 395:436-40. 2010
    The P-glycoprotein (P-gp, ABCB1) drug pump protects us from toxic compounds and confers multidrug resistance...
  52. doi CYP3A5 and ABCB1 polymorphisms influence tacrolimus concentrations in peripheral blood mononuclear cells after renal transplantation
    Arnaud Capron
    Department of Clinical Chemistry, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Brussels, Belgium
    Pharmacogenomics 11:703-14. 2010
    ..investigated the effect of genetic polymorphisms in a biotransformation enzyme (CYP3A5) and a transporter protein (ABCB1) on tacrolimus (Tac) whole blood concentrations in renal transplantation, and more specifically on peripheral ..
  53. doi Pim-1 kinase protects P-glycoprotein from degradation and enables its glycosylation and cell surface expression
    Yingqiu Xie
    University of Maryland Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Mol Pharmacol 78:310-8. 2010
    ..The ABC transporter P-glycoprotein (Pgp; ABCB1) also contains a Pim-1 phosphorylation consensus sequence, and we hypothesized that Pim-1 also regulates Pgp...
  54. doi Impact of genetic variants on post-clopidogrel platelet reactivity in patients after elective percutaneous coronary intervention
    Orsolya Rideg
    Institute of Laboratory Medicine, University of Pecs, 13 Ifjúság Street, H 7624 Pecs, Hungary
    Pharmacogenomics 12:1269-80. 2011
    ..To determine the effect of various SNPs on post-clopidogrel platelet reactivity and clinical outcome...
  55. ncbi Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein
    Tip W Loo
    Canadian Institutes of Health Research Group in Membrane Biology, Department of Medicine, University of Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 277:44332-8. 2002
    ..The results support the "substrate-induced fit" hypothesis for drug binding...
  56. ncbi CYP3A4 and MDR1 alleles in a Portuguese population
    Isa Cavaco
    Laboratory of Molecular Toxicology, CMQA, Faculty of Sciences and Technology, University of Algarve, Faro, Portugal
    Clin Chem Lab Med 41:1345-50. 2003
    ..In this study we have determined the frequencies of CYP3A4 and MDR1 alleles in Portuguese Caucasians...
  57. ncbi Caveolin-1 gene is coordinately regulated with the multidrug resistance 1 gene in normal and leukemic bone marrow
    Annie Pang
    University Department of Medicine, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, PR China
    Leuk Res 28:973-7. 2004
    ..The coordinate expression of caveolin-1 and MDR-1 suggests that they may either interact physically, or are involved in the same aberrant pathway(s) activated during MDR-1 up-regulation...
  58. ncbi Tacrolimus dosing in Chinese renal transplant patients is related to MDR1 gene C3435T polymorphisms
    D Li
    Organ Transplantation, The Third Xiangya Hospital, Changsha, Hunan, China
    Transplant Proc 38:2850-2. 2006
    ..The polymorphism C3435T of MDR1, the gene coding P-gp, may influence the expression and activity of P-gp...
  59. ncbi Polymorphisms of the MDR1 gene in the Czech population
    K Pechandová
    Clinical Pharmacology Unit, Department of Pharmacology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
    Folia Biol (Praha) 52:184-9. 2006
    ..Previously identified polymorphisms in the MDR1 gene belong to important factors causing this phenomenon...
  60. doi Tight junction regulation by morphine and HIV-1 tat modulates blood-brain barrier permeability
    Supriya D Mahajan
    Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Buffalo General Hospital, 301 Multi Research Bldg, 100 High Street, Buffalo, NY 14203, USA
    J Clin Immunol 28:528-41. 2008
    ..These studies may lead to the development of novel anti-HIV-1 therapeutics that target specific TJ proteins, thus preventing TJ disruption in opiate using HIV-1 patients...
  61. doi Structural insights into P-glycoprotein (ABCB1) by small angle X-ray scattering and electron crystallography
    Christopher A McDevitt
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK
    FEBS Lett 582:2950-6. 2008
    P-glycoprotein (ABCB1) is an ATP-binding cassette protein that is associated with the acquisition of multi-drug resistance in cancer and the failure of chemotherapy in humans...
  62. doi MDR1 single nucleotide polymorphism G2677T/A and haplotype are correlated with response to docetaxel-cisplatin chemotherapy in patients with non-small-cell lung cancer
    Ji Hong Pan
    Key Laboratory of the Ministry of Public Health for Biotech Drug, Key Laboratory for Modern Medicine and Technology of Shandong Province, Shandong Medicinal and Biotechnology Center, Shandong Academy of Medical Sciences, Jinan, China
    Respiration 78:49-55. 2009
    The multidrug resistance gene 1 (MDR1) encodes P-glycoprotein (P-gp), which plays an important role in mediating multidrug resistance to chemotherapeutic agents...
  63. doi Haplotypic structure of ABCB1/MDR1 gene modifies the risk of the acute allograft rejection in renal transplant recipients
    Stepan Bandur
    Transplant Laboratory, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Transplantation 86:1206-13. 2008
    ..Tac) and cyclosporine is determined by cytochrome P450IIIA and by P-glycoprotein encoded by the CYP3A4/CYP3A5 and ABCB1 genes...
  64. doi Influence of CYP3A5 genetic polymorphism on tacrolimus daily dose requirements and acute rejection in renal graft recipients
    Lina Quteineh
    Pharmacology Department, Pierre et Marie Curie University, Saint Antoine University Hospital, Paris, France
    Basic Clin Pharmacol Toxicol 103:546-52. 2008
    ..Our objective was to determine the influence of CYP3A5 and ABCB1 genetic polymorphisms on tacrolimus daily requirements and on transplantation outcome...
  65. doi MDR1 haplotypes conferring an increased expression of intestinal CYP3A4 rather than MDR1 in female living-donor liver transplant patients
    Keiko Hosohata
    Department of Pharmacy, Kyoto University Hospital, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Pharm Res 26:1590-5. 2009
    This study investigated whether haplotypes in the multidrug resistance 1 (MDR1) gene had effects on mRNA expression levels of MDR1 and cytochrome P450 (CYP) 3A4, and on the pharmacokinetics of tacrolimus in living-donor liver transplant (..
  66. doi Association of genetic polymorphisms in ESR2, HSD17B1, ABCB1, and SHBG genes with colorectal cancer risk
    J Sainz
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Endocr Relat Cancer 18:265-76. 2011
    ..COMT, HSD17B1, CYP1A1, CYP17A1, CYP1A2, CYP1B1, CYP2C9, CYP3A4, CYP2C19, and GSTP1), and hormone transporter (ABCB1) genes with the risk of CRC in German women and men, separately...
  67. ncbi Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans
    Silke Vogelgesang
    Departments of Neuropathology and Pharmacology, Peter Holtz Research Center of Pharmacology and Experimental Therapeutics, University of Greifswald, Greifswald, Germany
    Pharmacogenetics 12:535-41. 2002
    ..Our results provide the first evidence in human brain tissue that the accumulation of Abeta may be influenced by the expression of P-gp in blood vessels, and suggest that P-gp may influence the elimination of Abeta from brain...
  68. pmc P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model
    John R Cirrito
    Department of Neurology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Clin Invest 115:3285-90. 2005
    ..These data establish a direct link between Pgp and Abeta metabolism in vivo and suggest that Pgp activity at the BBB could affect risk for developing AD as well as provide a novel diagnostic and therapeutic target...
  69. doi Errors and reproducibility of DNA array-based detection of allelic variants in ADME genes: PHARMAchip
    Elisabet Cuyàs
    Human Pharmacology and Clinical Neurosciences Research Group of the Neuropsychopharmacology Program, Institut Municipal d Investigació Mèdica IMIM Hospital del Mar, Parc de Recerca Biomedica de Barcelona, c Dr Aiguader 88 08003 Barcelona, Spain
    Pharmacogenomics 11:257-66. 2010
    ..The aim of this study was to assess the suitability of PHARMAchip for the genotyping of polymorphisms of genes associated with drug metabolism and response as an alternative to Jurilab Ltd's DrugMEt Test...
  70. doi Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients
    Laure Elens
    Louvain Centre for Toxicology and applied Pharmacology, Universite Catholique de Louvain, 53 02, avenue E Mounier, 1200 Bruxelles, Belgium
    Pharmacogenomics 11:1223-34. 2010
    ..Previous studies have identified some possible genetic determinants of the variability in plasma concentrations. However, their impact on EFV intracellular pharmacokinetics remains mostly unexplored...
  71. ncbi Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene
    M Tanabe
    Department of Clinical Pharmacokinetics, Division of Pharmaceutical Sciences, Graduate School, Kyushu University, Fukuoka, Japan
    J Pharmacol Exp Ther 297:1137-43. 2001
    ....
  72. ncbi Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling
    Macus Tien Kuo
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas, TX 77030, USA
    Oncogene 21:1945-54. 2002
    The expression of P-glycoprotein encoded by the multidrug resistance (MDR1) gene is associated with the emergence of the MDR phenotype in cancer cells...
  73. ncbi Association between ABCB1 C3435T polymorphism and drug-resistant epilepsy in Han Chinese
    Patrick Kwan
    Division of Neurology, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
    Epilepsy Behav 11:112-7. 2007
    ..P-glycoprotein, encoded by the ABCB1 gene, is the most studied drug transporter...
  74. ncbi MDR1 genotype-related pharmacokinetics of digoxin after single oral administration in healthy Japanese subjects
    T Sakaeda
    Department of Hospital Pharmacy, School of Medicine, Kobe University, Japan
    Pharm Res 18:1400-4. 2001
    To evaluate the MDR1 genotype frequency in the Japanese population and to study the relationship between the MDR1 genotype and the pharmacokinetics of digoxin after single oral administration in healthy subjects.
  75. ncbi Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin
    Pornngarm Limtrakul
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    Mol Cell Biochem 296:85-95. 2007
    ..proteins, P-glycoprotein (P-gp or ABCB1), mitoxantrone resistance protein (MXR or ABCG2) and multidrug resistance protein 1 (MRP1 or ABCC1) was investigated, to assess whether an ultimate metabolite form of curcuminoids (THC) ..
  76. doi ABCB1 (MDR 1) polymorphisms and progression-free survival among women with ovarian cancer following paclitaxel/carboplatin chemotherapy
    Sharon E Johnatty
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Clin Cancer Res 14:5594-601. 2008
    The human ABCB1 gene encodes P-glycoprotein, which transports a broad range of anticancer drugs, including paclitaxel...
  77. pmc Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling
    Yong Yu Liu
    Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, Monroe, Louisiana 71209, USA
    Mol Cancer 9:145. 2010
    Drug resistance is the outcome of multiple-gene interactions in cancer cells under stress of anticancer agents. MDR1 overexpression is most commonly detected in drug-resistant cancers and accompanied with other gene alterations including ..
  78. ncbi Association of an ABCB1 gene haplotype with pharmacoresistance in temporal lobe epilepsy
    F Zimprich
    Department of Clinical Neurology, Medical University of Vienna, Austria
    Neurology 63:1087-9. 2004
    ..To assess the role of functional variations in its coding gene (ABCB1) the authors genotyped 210 patients with TLE who were stratified according to their degree of drug resistance...
  79. ncbi Irinotecan pathway genotype analysis to predict pharmacokinetics
    Ron H J Mathijssen
    Department of Medical Oncology, Erasmus MC Daniel den Hoed Cancer Center, 3075 EA Rotterdam, The Netherlands
    Clin Cancer Res 9:3246-53. 2003
    ..The purpose was to explore the relationships between irinotecan disposition and allelic variants of genes coding for adenosine triphosphate binding cassette transporters and enzymes of putative relevance for irinotecan...
  80. pmc MDR1 Ala893 polymorphism is associated with inflammatory bowel disease
    Steven R Brant
    The Harvey M and Lyn P Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Hum Genet 73:1282-92. 2003
    ..Contained within this region is the gene for MDR1 (multidrug resistance), a membrane transport protein for which human polymorphisms have been reported in Ala893Ser/..
  81. ncbi Polymorphisms in multidrug resistance 1 (MDR1) gene are associated with refractory Crohn disease and ulcerative colitis
    U Potocnik
    Laboratory of Molecular Genetics, Institute of Pathology, Medical Faculty, Ljubljana, Slovenia
    Genes Immun 5:530-9. 2004
    We used coding and noncoding polymorphisms evenly spaced across the ABCB1/MDR1 gene to perform association analysis in Slovenian patients with inflammatory bowel diseases and to obtain haplotype structure and patterns of linkage ..
  82. doi Genetic determinants of response to clopidogrel and cardiovascular events
    Tabassome Simon
    Assistance Publique Hopitaux de Paris, Hopital Saint Antoine, and Universite Pierre et Marie Curie, Paris 06, France
    N Engl J Med 360:363-75. 2009
    ..The effect of these determinants on clinical outcomes after an acute myocardial infarction is unknown...
  83. pmc Contribution of cytochrome P450 and ABCB1 genetic variability on methadone pharmacokinetics, dose requirements, and response
    Francina Fonseca
    Institut de Neuropsiquiatria i Addiccions Parc de Salut Mar, Barcelona, Spain
    PLoS ONE 6:e19527. 2011
    ..Pharmacokinetic factors could explain some but not all differences in MMT outcome and methadone dose requirements...
  84. doi Clinical, angiographic, and genetic factors associated with early coronary stent thrombosis
    Guillaume Cayla
    Institut de Cardiologie, INSERM Unité Mixte de Recherche_S 937, Pitie Salpetriere Hospital, Paris, France
    JAMA 306:1765-74. 2011
    ..Despite dual antiplatelet therapy, stent thrombosis remains a devastating and unpredictable complication of percutaneous coronary intervention (PCI)...
  85. doi Association of a polymorphism of ABCB1 with obesity in Japanese individuals
    Sahoko Ichihara
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514 8507, Japan
    Genomics 91:512-6. 2008
    ..only the 2677G --> A/T polymorphism (rs2032582) of the ATP-binding cassette, subfamily B, member 1 gene (ABCB1) was significantly associated (p=0.0003) with obesity...
  86. doi PXR pharmacogenetics: association of haplotypes with hepatic CYP3A4 and ABCB1 messenger RNA expression and doxorubicin clearance in Asian breast cancer patients
    Edwin Sandanaraj
    Laboratory of Clinical Pharmacology, Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, Singapore, Singapore
    Clin Cancer Res 14:7116-26. 2008
    ..and to investigate the association between PXR haplotypes and hepatic mRNA expression of PXR and its downstream target genes, CYP3A4 and ABCB1, as well as their influence on the clearance of doxorubicin in Asian breast cancer patients.
  87. ncbi ABCB1 gene polymorphisms and expression of P-glycoprotein and long-term prognosis in colorectal cancer
    Sara De Iudicibus
    Department of Life Sciences, University of Trieste, Italy
    Anticancer Res 28:3921-8. 2008
    P-glycoprotein (Pgp), encoded by the ATP-binding cassette B1 (ABCB1) gene, is an efflux transporter located on the luminal side of intestinal epithelial cells, which protects the gut from endogenous and exogenous toxins...
  88. pmc CDX2 regulates multidrug resistance 1 gene expression in malignant intestinal epithelium
    Yuji Takakura
    Department of Surgery, Hiroshima University, Hiroshima, Japan
    Cancer Res 70:6767-78. 2010
    ..Microarray-based gene expression studies revealed that the Multidrug Resistance 1 (MDR1/P-glycoprotein/ABCB1) gene was activated by CDX2...
  89. ncbi Regulation of MDR1 expression and drug resistance by a positive feedback loop involving hyaluronan, phosphoinositide 3-kinase, and ErbB2
    Suniti Misra
    Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 280:20310-5. 2005
    ..These Akt-independent effects are dominant over the effects of Akt on doxorubicin resistance in MCF-7/Adr cells...
  90. doi Common ATP-binding cassette B1 variants are associated with increased digoxin serum concentration
    Albert Jan L H J Aarnoudse
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    Pharmacogenet Genomics 18:299-305. 2008
    Digoxin is a known substrate of ATP-binding cassette B1 (ABCB1/MDR1). The results of studies on the association between ABCB1 polymorphisms and digoxin kinetics, however, remain contradictory...
  91. pmc A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function
    King Leung Fung
    Laboratory of Cell Biology, Center of Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 2108, Bethesda, MD 20892 4254, USA
    Biochim Biophys Acta 1794:860-71. 2009
    The MDR1 (ABCB1) gene encodes a membrane-bound transporter that actively effluxes a wide range of compounds from cells. The overexpression of MDR1 by multidrug-resistant cancer cells is a serious impediment to chemotherapy...
  92. pmc Association between Genetic Polymorphism of Multidrug Resistance 1 Gene and Sasang Constitutions
    Hyun Ju Kim
    Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, 344 2 Shinyong dong, Iksan, Jeonbuk, 570 749, Republic of Korea Tel
    Evid Based Complement Alternat Med 6:73-80. 2009
    Multidrug resistance 1 (MDR1) is a gene that expresses P-glycoprotein (P-gp), a drug transporter protein...
  93. ncbi MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity
    M M Ameyaw
    University of Aberdeen, Department of Medicine and Therapeutics, Institute of Medical Sciences, Foresterhill, Aberdeen, UK
    Pharmacogenetics 11:217-21. 2001
    P-glycoprotein (PGP), the product of the multidrug resistance gene (MDR1), acts as an energy-dependent efflux pump that exports its substrates out of the cell...
  94. ncbi Association of the multidrug resistance-1 gene single-nucleotide polymorphisms with the tacrolimus dose requirements in renal transplant recipients
    Dany Anglicheau
    Unité INSERM UMR S490, Molecular Toxicology, Centre Universitaire des Saints Peres, Universite Rene Descartes, 45 Rue des Saints Peres, 75006 Paris, France univ paris5 fr
    J Am Soc Nephrol 14:1889-96. 2003
    ..interindividual variations, is a substrate for P-glycoprotein (P-gp), the product of the multidrug resistance-1 (MDR1) gene...
  95. ncbi Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan
    Kimie Sai
    Project Team for Pharmacogenetics, Division of Xenobiotic Metabolism and Disposition, National Institute of Health Sciences, 1 18 1, Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Pharmacogenetics 13:741-57. 2003
    We performed comprehensive haplotyping of ABCB1/MDR1 gene blocks using 49 genetic polymorphisms, including seven novel ones, obtained from 145 Japanese subjects...
  96. ncbi The effect of MDR1 (ABCB1) polymorphism on the pharmacokinetic of tacrolimus in Turkish renal transplant recipients
    S H Akbas
    Central Laboratory, Akdeniz University, Faculty of Medicine, Antalya, Turkey
    Transplant Proc 38:1290-2. 2006
    ..TRL is a substrate for P-glycoprotein (P-gp), the product of the multidrug resistance-1 (MDR1)(ABCB1) gene. P-gp acts as a membrane efflux pump, which affects TRL absorption from the gut...
  97. ncbi MDR1 polymorphism influences the outcome of multiple myeloma patients
    Gabriele Buda
    Department of Oncology, Transplants and Advanced Technologies, Section of Hematology, Pisa University, Pisa, Italy
    Br J Haematol 137:454-6. 2007
    The multidrug resistance gene (MDR1) has been reported to be an additional prognostic factor in acute myeloid leukaemia patients...
  98. ncbi Associations of ABCB1, ABCC2, and ABCG2 polymorphisms with irinotecan-pharmacokinetics and clinical outcome in patients with advanced non-small cell lung cancer
    Ji Youn Han
    Research Institute and Hospital, National Cancer Center, Goyang, Korea
    Cancer 110:138-47. 2007
    The authors investigated whether ABCB1, ABCC2, and ABCG2 genetic polymorphisms affect pharmacokinetics (PK) of irinotecan and treatment outcome of patients with advanced nonsmall cell lung cancer (NSCLC).
  99. ncbi Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins
    C J Chen
    Department of Genetics, University of Illinois, Chicago 60612
    J Biol Chem 265:506-14. 1990
    The MDR1 gene, responsible for multidrug resistance in human cells, encodes a broad specificity efflux pump (P-glycoprotein)...
  100. ncbi Complex haplotypic effects of the ABCB1 gene on epilepsy treatment response
    Chin Chuan Hung
    National Taiwan University Hospital and College of Medicine, NTU, Department of Pharmacology, 1 Jen Ai Road, Section 1, Taipei, Taiwan 100
    Pharmacogenomics 6:411-7. 2005
    The aim of this study was to investigate the association of the complex haplotype system of the adenosine triphosphate-binding cassette B1 (ABCB1) gene with the epilepsy treatment response.
  101. doi Associations between variants in the ABCB1 (MDR1) gene and corticosteroid dependence in children with Crohn's disease
    Alfreda Krupoves
    Research Centre, Ste Justine Hospital, Montreal, Quebec, Canada
    Inflamm Bowel Dis 17:2308-17. 2011
    ..Identification of molecular markers of CS dependence is of paramount importance. The ABCB1 gene codes for P-glycoprotein, a transporter involved in the metabolism of CS...

Research Grants67

  1. Drug Interactions at the Human Blood-Brain Barrier
    Jashvant D Unadkat; Fiscal Year: 2010
    ..Prominent amongst these is P-glycoprotein (P-gp), an ABC efflux transporter encoded by the multi-drug resistance 1 (MDR1) gene [2]...
  2. DEVELOPMENT OF NEW SEMISYNTHETIC TAXANES
    Ralph Bernacki; Fiscal Year: 2001
    ..Clearly, second generation taxanes that have improved therapeutic activity against multi-drug resistant (MDR1 gene mediated) tumors would be advantageous...
  3. Impact of genetic variation on response to GO therapy in COG-AML clinical trials
    ROLAND BRUNO WALTER; Fiscal Year: 2013
    ..internalization/trafficking of the CD33/GO complex, and drug efflux mediated by P-glycoprotein (encoded by ABCB1) for GO efficacy...
  4. The Role of P-glycoprotein in Sitagliptin Clinical Pharmacology
    Christina L Aquilante; Fiscal Year: 2010
    ..Common functional polymorphisms exist in multidrug resistance 1 (MDR1), the gene that encodes P-glycoprotein, and these polymorphisms are often studied in haplotype form...
  5. Jessica L Mega; Fiscal Year: 2014
    ..in thienopyridine absorption and metabolism, including the intestinal efflux pump P-glycoprotein (encoded by MDR1) and carboxylesterases 1 and 2 (encoded by CES1 and CES2)...
  6. Identification of Lactobacillus Secreted Factors in Regulation of Pgp
    Seema Saksena; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): P-glycoprotein (P-gp/MDR1), encoded by the ABCB1 gene is abundantly expressed on the apical surface of intestinal epithelial cells...
  7. St. John's wort for Drug Abuse Treatment During Pregnancy
    C LINDSAY LINDSAY DEVANE; Fiscal Year: 2012
    ..The research will use pregnant Sprague-Dawley rats as a model for pregnancy. Morphine is a substrate of the ABCB1 gene product, P-glycoprotein (P-gp), that we have shown in preliminary data can be induced by SJW...
  8. Genomic and Cellular Markers and Chronic Renal Allograft Function
    Kathleen M Tornatore; Fiscal Year: 2010
    ..These aims will extend our initial four-hour studies of time-dependent responses of MDR1 gene expression, intracellular cytokines (IL-2 and IL-4) and extracellular immunodynamic responses of CD4+ and CD8+ ..
  9. IMAGING FUNCTIONAL P-GLYCOPROTEIN TRANSPORT AT THE BBB IN ALZHEIMER'S DISEASE
    Vijay Sharma; Fiscal Year: 2011
    ..Recently, it has been shown that MDR1 P-glycoprotein (Pgp), located on the luminal surface of capillary endothelial cells, mediates the final step of AB ..
  10. Structural Biology and Inhibition of MDR ABC Transporters
    Geoffrey Chang; Fiscal Year: 2009
    ..to these compounds should provide a great insight into the molecular structural basis of drug transport by human MDR1 (P-glycoprotein), which causes cancer drug resistance...
  11. BIOCHEMICAL CHARACTERIZATION OF P-GLYCOPROTEIN
    AHMAD SAFA; Fiscal Year: 1999
    DESCRIPTION: (Applicant's Abstract) P-glycoprotein (P-gp) encoded by the MDR1 gene, causes multidrug resistance (MDR) to unrelated natural product drugs in human tumor cells, and functions as an ATP-dependent efflux pump...
  12. Vaginal Drug Delivery of P-glycoprotein Substrates
    Giovanni Pauletti; Fiscal Year: 2003
    ..The MDR1 gene product P-gp is a prototype of membrane efflux systems that limit transcellular transport of drug molecules ..
  13. HUMAN MULTIDRUG RESISTANCE (P GLYCOPROTEIN) GENES
    IGOR RONINSON; Fiscal Year: 1999
    Expression of the human MDR1 (multidrug resistance) gene results in cross-resistance to a diverse group of lipophilic drugs that includes many commonly used anticancer agents...
  14. ABCB5 P-Glycoprotein in Cancer Multidrug Resistance
    Markus H Frank; Fiscal Year: 2010
    Multidrug resistance (MDR) mediated by MDR1 (ABCB1) P-glycoprotein and related ATP-binding cassette (ABC) transporters is an impediment to successful cancer therapy...
  15. P-Glycoprotein and Disposition of Psychostimulants
    JOHN MARKOWITZ; Fiscal Year: 2005
    ..The most prominent gene of the ABC cassette family of transporters, ABCB1 (also known as MDR1), is highly polymorphic and encodes for P-glycoprotein (PGP)...
  16. Role of the ABC Transporter ABCB6 in Cytotoxicity
    John Schuetz; Fiscal Year: 2006
    ..Our studies have sought to understand the function and regulation of ABC transporters with a focus on the MDR1 gene that encodes a protein conferring resistance to a large number of therapeutic drugs and cytotoxic compounds...
  17. FUNCTION OF P-GLYCOPROTEIN IN KIDNEY CELLS
    ELSA BELLO REUSS; Fiscal Year: 1999
    ..Adapted from Investigator's Abstract): The multidrug resistance P-Glycoprotein (PGP), the product of the human MDR1 and the murine mdr1 or the mdr3 genes is a membrane protein that extrudes chemotherapeutic drugs...
  18. A New High Throughput Assay for Human MDR1 Substrates
    Eugene Mechetner; Fiscal Year: 2001
    ..a high throughput assay for cost/time-efficient screening and characterizing of compounds transported by human MDR1 P-glycoprotein (Pgp)...
  19. Two Photon Imaging of Drug Uptake Efflux & Modulation in MDR Tumor Cells in vivo
    AHMAD SAFA; Fiscal Year: 2007
    ..Both proteins, P-glycoprotein (Pgp, product of the MDR1 gene) and the Multidrug resistance Related Protein (MRP, product of the MRP1 gene) are membrane transporters that ..
  20. MDR1 GENE THERAPY IN CD34+ CELLS AND SCID MICE
    James Doroshow; Fiscal Year: 2002
    The human MDR1 gene encodes a multispecific drug transporter, P- glycoprotein (Pgp), that prevents drug accumulation in resistant cells. Overexpression of MDR1 is sufficient for conferring multidrug resistance on otherwise normal cells...
  21. CNS specific Knock-out and Multidrug Transport
    RODNEY HO; Fiscal Year: 2006
    Development of transgenic animals with MDR1 gene deletions (null mutation) in all tissues, has provided limited understanding of biologic and transport functions of MDR1 product, P-glycoprotein or Pgp in modulating efficacy and toxicity ..
  22. REGULATION OF P GLYCOPROTEIN BY PHOSPHORYLATION
    Shakeel Ahmad; Fiscal Year: 1999
    ..MDR can be increased in MDR1-expressing human breast cancer cells following transfection with PKC-alpha, and this effect is associated with ..
  23. Persistent Replication of HIV-1 in Children
    NICOLE TOBIN; Fiscal Year: 2005
    ..a potential viral reservoir and site of persistent replication, and the host multi-drug resistance genotype (MDR1) C/C genotype, a host genetic factor associated with poor therapeutic outcomes in varied diseases, also have an ..
  24. Pharmacogenetics of Tamoxifen and Chemotherapies and Risk of Contralateral Breast
    Jane C Figueiredo; Fiscal Year: 2010
    ..e., CYP3A5, GSTM1, GSTP1, GSTT1);anthracyclines (i.e., CYP3A5, MDR1, GSTM1, GSTP1, GSTT1) and antimetabolites (i.e., DHFR, TS, MTHFR) ...
  25. MODULATION OF MULTIDRUG RESISTANCE MECHANISMS
    Branimir Sikic; Fiscal Year: 2002
    ..Studies of new modulators of MDR1/P-glycoprotein (P-gp) multidrug resistance (MDR) will continue...
  26. IMAGING MULTIDRUG RESISTANCE AND MODULATION IN BREAST CA
    David Piwnica Worms; Fiscal Year: 2002
    ..Emergence of multidrug resistance (MDR) in breast cancer mediated by the MDR1 P-glycoprotein has been associated with poor response to chemotherapy and a shorter overall survival...
  27. INTERACTIONS OF P GLYCOPROTEIN WITH CYTOCHROME P4503A
    Erin Schuetz; Fiscal Year: 2001
    ..Our recent studies have established that the product of the multidrug resistance gene (MDR1), the drug efflux transporter P-glycoprotein (Pgp), influences the pharmacological disposition of rifampicin and is ..
  28. Barry M Lester; Fiscal Year: 2015
    ..Finally, single nucleotide polymorphisms (SNPs) in the multi-drug resistance (MDR1), mu opioid receptor (OPRM1), and/or catechol-O-methyltransferase (COMT) genes (pharmacogenetic modulators of ..
  29. MDR1 IN HUMAN INTESTINE
    Kenneth Lown; Fiscal Year: 1999
    b>MDR1 (multiple drug resistance) is a versatile ATP-dependent pump which transports a variety of unrelated substances from the cytoplasm to reduce their intracellular accumulation...
  30. NON-GENETIC CELL HETEROGENEITY IN TUMOR EVOLUTION
    Sui Huang; Fiscal Year: 2007
    ..Moreover, expression of MDR1 that confers drug resistance is not an isolated idiosyncratic trait but an intrinsic property of adult stem cells, ..
  31. CANCER CHEMOTHERAPY IN TRANSGENIC RATS AND MICE
    JON GORDON; Fiscal Year: 1993
    ..First, the gene encoding multiple drug resistance (mdr1), a protein known to confer high resistance to Dox, will be directed to express in hearts of transgenic mice and ..
  32. MUTANT P53 GAIN OF FUNCTION IN TUMORIGENESIS
    Gerard Zambetti; Fiscal Year: 2007
    ..has long been considered to be linked to its ability to selectively transactivate the human multi-drug resistance (MDR1) promoter...
  33. TARGETING CANCER CELL DNA WITH COMBINATORIAL LIGANDS
    Rudolph Juliano; Fiscal Year: 2005
    ..I we will build on our recent progress and evaluate the actions of novel repressors targeted to the promoter of the MDR1 multi-drug resistance gene...
  34. Canine model for assessing CNS access P-gp substrates
    KATRINA MEALEY; Fiscal Year: 2005
    The overall goal of the proposed research is to validate a P-glycoprotein (P-gp) deficient canine model [MDR1(mut/mut)] for delineating the role of P-gp in restricting access of therapeutic agents to the central nervous system (CNS)...
  35. Frances M Brodsky; Fiscal Year: 2014
    ..Work from the past funding period has defined through structural and biochemical studies how CLCs also contribute to regulation of clathrin lattice formation...
  36. Structure and function of chloride channels and transporters
    Alessio Accardi; Fiscal Year: 2013
    ..The human genome encodes for 9 CLCs, 5 of which are transporters and 4 are channels...
  37. Metagenomic profiling of oral polymicrobial flora in head and neck cancers
    Charis Eng; Fiscal Year: 2011
    ..association between the presence of particular bacterial subpopulations per metabiomic profiling and MDR1 methylation status in HNSCC...
  38. Kishor K Bhakat; Fiscal Year: 2015
    ..with partner proteins and modulate its DNA repair activity and expression of the drug-efflux transporter protein MDR1 via its transcriptional regulatory function...
  39. Timothy F Osborne; Fiscal Year: 2016
    ..We also showed CCK/gastrin increases expression and activity of the ABCB1 efflux transporter, which is known to prevent cellular uptake of a wide range of toxic organic small molecules...
  40. Quiescent Tc17 programmed CD8 T cells and their role in graft versus host disease
    CAMERON JOHN TURTLE; Fiscal Year: 2012
    ..for acute leukemia, and identified a subset of self-renewing CD8+ T cells that expresses high levels of ABCB1, enabling them to efflux chemotherapy drugs and provide a persistent reservoir of memory T cells during ..
  41. CAMERON JOHN TURTLE; Fiscal Year: 2015
    ..for acute leukemia, and identified a subset of self-renewing CD8+ T cells that expresses high levels of ABCB1, enabling them to efflux chemotherapy drugs and provide a persistent reservoir of memory T cells during ..
  42. Stanley B Prusiner; Fiscal Year: 2016
    ..when the level of quinacrine was increased almost 100-fold, in the brains of mice in which the P-gp transporter (Mdr1) has been knocked out, above the halfeffective concentration (EC50) in cultured cells, it failed to extend the ..
  43. Kevin Strange; Fiscal Year: 2016
    ..Despite intensive study and their physiological importance, very little is known about how ClCs are regulated...
  44. SOPHIA MAJEED; Fiscal Year: 2014
    ..both the light chain subunits f clathrin, and actin, and the interaction between Hip and the clathrin light chains (CLCs) is suspected to play a key role in actin reorganization and cell motility in migrating tumor cells...
  45. In vivo proof of efficacy studies for a novel glucosylceramide synthase inhibitor
    JAMES ALAN SHAYMAN; Fiscal Year: 2013
    ..design of inhibitors of glucosylceramide synthase that lack recognition by the multidrug resistance transporter MDR1 utilizing the previously defined pharmacophore for eliglustat tartrate...
  46. David J Shapiro; Fiscal Year: 2014
    ..and potential anticancer agents based on reducing expression of c-Myc and other oncogenes, MDR1 (multidrug resistance protein 1) and NF-?B by targeting the mRNA binding protein IMP-1/CRD-BP/IGF2BP1...
  47. CHRISTOPHER PAUL LANDRIGAN; Fiscal Year: 2016
    ..In response, beginning in July 2011, the Accreditation Council for Graduate Medical Education (ACGME) will limit PGY1 residents to no more than 16 consecutive work hours...
  48. Tamara Minko; Fiscal Year: 2014
    ..siRNA targeted to MDR1 and CD44 mRNA will be investigated as suppressors of pump resistance...
  49. Nicola Marchi; Fiscal Year: 2016
    ..are present in DRE EC;these enzymes are responsible for the metabolism of 1st and 2nd generation AEDs;c) CYP3A4 and MDR1 co-localize at the BBB (and neurons) in human DRE brain;d) Overexpression of CYP3A4 in DRE EC is associated with ..
  50. Impact of Pregnancy Disease on the Regulation of Placenta Drug Transport
    Clifford W Mason; Fiscal Year: 2013
    ..My preliminary data indicate there is up- regulation of the drug efflux transporters, multidrug resistance protein 1 (MDR1) and breast cancer resistance protein (BCRP), in the placenta of women with infection and ..
  51. Development of a Multidimensional Pain Measure for Persons with Dementia
    Andrea Lynn Snow; Fiscal Year: 2013
    ..The total patient sample will be comprised of residents from 4 large VA Community Living Centers (CLCs;Philadelphia, Coatesville, Atlanta, Tuscaloosa). We will enroll veterans with moderate to severe dementia...
  52. VA Post-Stroke Rehabilitation: Comparing Institutional Long-Term Care Settings
    Huanguang Jia; Fiscal Year: 2013
    ..applicant): Background: Each year, approximately 3,900 and 14,100 Veterans reside in VA community living centers (CLCs) and VA per diem contracted community nursing homes (CNHs) for post-stroke care, respectively...
  53. The role of MRP1 in Protection of Cardiac Injury
    Mary Vore; Fiscal Year: 2012
    SPACE PROVIDED. ' The goal of the present application is to characterize the role of multidrug resistance protein 1 (Mrp1) in protecting the heart from oxidative stress...
  54. Implementing and Evaluating INTERACT in VA CLCs
    Vincent Mor; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Transfers from nursing homes (NHs) or community living centers (CLCs) to hospitals place residents at risk for iatrogenic events, disruptions in care, disorientation, stress and increase costs...
  55. JAMES ALAN SHAYMAN; Fiscal Year: 2015
    ..g. MDR1) at the blood brain barrier, and by the use of dual cell-based assays for GlcCer synthase inhibition that ..
  56. YUELIAN XU; Fiscal Year: 2014
    ..Permeability in Caco-2 >5 cm x 10-6/sec;Protein binding <99%;asymmetry in MDR1-transfected MDCK cell lines <2.5 4...
  57. AIDS Related Candidiasis: Dynamic Expression of Drug Resistant Genes
    Theodore C White; Fiscal Year: 2010
    ..known to be constitutively overexpressed include the target enzyme ERG11, and three efflux pumps, CDR1, CDR2, and MDR1. In susceptible Ca, these genes can be transcriptionally induced when exposed to drugs...
  58. In Vivo Bioimaging Model to Study Inducible Drug Resistance in Cancer
    Susan E Kane; Fiscal Year: 2013
    ..One mechanism of MDR is the enhanced expression of the MDR1 gene...
  59. Susan M Allen; Fiscal Year: 2015
    ..of VA nursing homes from primarily long stay institutions to short (post-acute) stay Community Living Centers (CLCs) in which Veterans receive restorative and rehabilitative care in a home environment that discourages dependency ..
  60. Piero Anversa; Fiscal Year: 2015
    ..Human CSCs express the stem cell antigens c-kit, MDR1 and Sca-1-like alone or in various combinations...
  61. Laura K Barger; Fiscal Year: 2016
    ..that sleep will be increased, and the incidence rates of MVCs and percutaneous injuries will be decreased among PGY1 residents working under the new ACGME Common Program Requirements (2011) that limit the duration of work shifts to ..
  62. Role of the mitochondrial ABC protein ABCB6 in drug resistance
    Gergely Szakacs; Fiscal Year: 2010
    ..Despite the established role of ABC transporters in detoxification, this concept remains challenging. ABCB1-MDR1 provides resistance by keeping the intracellular levels of various anticancer agents below a cell-killing ..
  63. Effects of Mental Health Disorders on Pain Monitoring and Treatment in VA CLCs
    Penny Brennan; Fiscal Year: 2013
    ..on the types and outcomes of pain treatment they receive as residents in VA Community Living Centers (VA CLCs). Effective pain treatment is a key objective throughout the VA health care system, but particularly in VA CLCs...
  64. Item Banking Across the Continuum of Care
    Craig A Velozo; Fiscal Year: 2013
    ..measurement system that builds upon the well-established VHA infrastructure use of the FIM in IRFs and the MDS in CLCs. The proposed measurement system will use contemporary item banking methodologies to provide practitioners with: 1) ..
  65. Ceramide, Membrane Glycolipids and Glycoprotein Expression
    Myles C Cabot; Fiscal Year: 2010
    ..Glycolipids such as GC are also substrates for ABC transporter proteins, of which the MDR1 protein, P-glycoprotein (P-gp) is a member...