ABCA7

Summary

Gene Symbol: ABCA7
Description: ATP binding cassette subfamily A member 7
Alias: ABCA-SSN, ABCX, AD9, ATP-binding cassette sub-family A member 7, ATP-binding cassette, sub-family A (ABC1), member 7, autoantigen SS-N, macrophage ABC transporter
Species: human

Top Publications

  1. ncbi Role of ATP-binding cassette transporters in brain lipid transport and neurological disease
    Woojin Scott Kim
    Prince of Wales Medical Research Institute, Sydney, New South Wales, Australia
    J Neurochem 104:1145-66. 2008
  2. ncbi ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux
    Nan Wang
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 278:42906-12. 2003
  3. ncbi Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7
    Michi Hayashi
    Biochemistry, Cell Biology, and Metabolism, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    J Lipid Res 46:1703-11. 2005
  4. pmc ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages
    Andreas W Jehle
    Department of Medicine, Columbia University, New York, NY 10032, USA
    J Cell Biol 174:547-56. 2006
  5. pmc Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
    Paul Hollingworth
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 43:429-35. 2011
  6. pmc Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
    Adam C Naj
    The John P Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA
    Nat Genet 43:436-41. 2011
  7. ncbi The ATP-binding cassette transporter ABCA2 as a mediator of intracellular trafficking
    J T Mack
    Department of Cell and Molecular Pharmacology, Medical University of South Carolina, P O Box 250505, 173 Ashley Avenue, Charleston, SC 29425, USA
    Biomed Pharmacother 60:587-92. 2006
  8. pmc Replication of EPHA1 and CD33 associations with late-onset Alzheimer's disease: a multi-centre case-control study
    Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Mol Neurodegener 6:54. 2011
  9. pmc Effects of deletion of macrophage ABCA7 on lipid metabolism and the development of atherosclerosis in the presence and absence of ABCA1
    Illiana Meurs
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    PLoS ONE 7:e30984. 2012
  10. doi Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer's disease
    E Rodriguez-Rodriguez
    Neurology Service, Neurology Department and CIBERNED, Marqués de Valdecilla University Hospital University of Cantabria and IFIMAV, 39008 Santander, Spain
    J Neural Transm (Vienna) 120:807-12. 2013

Research Grants

  1. CRAIG STEPHEN ATWOOD; Fiscal Year: 2014
  2. Heba Nowyhed; Fiscal Year: 2015
  3. Richard P Mayeux; Fiscal Year: 2016
  4. M Ilyas Kamboh; Fiscal Year: 2016
  5. ABCA7: Cellular Functions and Role in Atherosclerosis
    Alan Tall; Fiscal Year: 2009
  6. GENOMIC ANALYSIS OF ALZHEIMERS DISEASE GENES
    Gerard Schellenberg; Fiscal Year: 2002
  7. Cloning of Late-onset Alzheimer's Disease Genes
    Gerard Schellenberg; Fiscal Year: 2007
  8. 4/5-Elucidating the Genetic Architecture of Autism by Deep Genomic Sequencing
    GERARD DAVID SCHELLENBERG; Fiscal Year: 2010
  9. Stress, Coping, and Well-Being of Custodial Grandparents
    Gregory Smith; Fiscal Year: 2003
  10. Better Breast Health for Korean American Women
    Hae Ra Han; Fiscal Year: 2006

Scientific Experts

Detail Information

Publications108 found, 100 shown here

  1. ncbi Role of ATP-binding cassette transporters in brain lipid transport and neurological disease
    Woojin Scott Kim
    Prince of Wales Medical Research Institute, Sydney, New South Wales, Australia
    J Neurochem 104:1145-66. 2008
    ..active ABC transporters in the human genome, we have focused on 13 transporters (ABCA1, ABCA2, ABCA3, ABCA4, ABCA7 and ABCA8; ABCB1 and ABCB4; ABCD1 and ABCD2; ABCG1, ABCG2, and ABCG4) for which there is evidence suggesting they ..
  2. ncbi ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux
    Nan Wang
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 278:42906-12. 2003
    ..Based on a high degree of sequence homology between ABCA1 and ABCA7, a transporter of unknown function, we investigated the possibility that ABCA7 might be involved in apolipoprotein ..
  3. ncbi Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7
    Michi Hayashi
    Biochemistry, Cell Biology, and Metabolism, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    J Lipid Res 46:1703-11. 2005
    ..apolipoprotein and cellular lipid was studied using HEK293 cells to which ecdysone-inducible human ABCA1 or human ABCA7 was transfected...
  4. pmc ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages
    Andreas W Jehle
    Department of Medicine, Columbia University, New York, NY 10032, USA
    J Cell Biol 174:547-56. 2006
    ..Using RNA interference or gene targeting, we show that knock down of macrophage ABCA7 but not -A1 results in defective engulfment of apoptotic cells...
  5. pmc Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
    Paul Hollingworth
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 43:429-35. 2011
    ..Meta-analyses of all data provided compelling evidence that ABCA7 (rs3764650, meta P = 4.5 × 10(-17); including ADGC data, meta P = 5...
  6. pmc Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
    Adam C Naj
    The John P Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA
    Nat Genet 43:436-41. 2011
    ..3 × 10(-8), P(J) = 1.9 × 10(-8)), BIN1 (rs7561528; P(M) = 4.0 × 10(-14), P(J) = 5.2 × 10(-14)) and PICALM (rs561655; P(M) = 7.0 × 10(-11), P(J) = 1.0 × 10(-10)), but not at EXOC3L2, to late-onset Alzheimer's disease susceptibility...
  7. ncbi The ATP-binding cassette transporter ABCA2 as a mediator of intracellular trafficking
    J T Mack
    Department of Cell and Molecular Pharmacology, Medical University of South Carolina, P O Box 250505, 173 Ashley Avenue, Charleston, SC 29425, USA
    Biomed Pharmacother 60:587-92. 2006
    ..Enhanced expression of ABCA2 and related proteins, including ABCA1, ABCA4 and ABCA7, is found in human macrophages upon bolus cholesterol treatment...
  8. pmc Replication of EPHA1 and CD33 associations with late-onset Alzheimer's disease: a multi-centre case-control study
    Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Mol Neurodegener 6:54. 2011
    ..Meta-analyses of this and a previously published GWAS revealed significant association at ABCA7 and MS4A, independent evidence for association of CD2AP, CD33 and EPHA1 and an opposing yet significant ..
  9. pmc Effects of deletion of macrophage ABCA7 on lipid metabolism and the development of atherosclerosis in the presence and absence of ABCA1
    Illiana Meurs
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    PLoS ONE 7:e30984. 2012
    b>ABCA7, a close relative of ABCA1 which facilitates cholesterol efflux to lipid-poor apoproteins, has been implicated in macrophage lipid efflux and clearance of apoptotic cells in in vitro studies...
  10. doi Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer's disease
    E Rodriguez-Rodriguez
    Neurology Service, Neurology Department and CIBERNED, Marqués de Valdecilla University Hospital University of Cantabria and IFIMAV, 39008 Santander, Spain
    J Neural Transm (Vienna) 120:807-12. 2013
    ..3 months) identified 118 MCI-converters to AD and 170 MCI-nonconverters. We genotyped ABCA7 rs3764650, BIN1 rs744373, CD2AP rs9296559, CLU rs1113600, CR1 rs1408077, MS4A4E rs670139, MS4A6A rs610932, and ..
  11. ncbi An evaluation of the mechanism of ABCA7 on cellular lipid release in ABCA7-HEC293 cell
    Cheng ai Wu
    Department of Molecular Orthopaedics, Beijing Institute of Traumatology and Orthopaedics, Beijing 100035, China
    Chin Med J (Engl) 126:306-10. 2013
    b>ABCA7 is a member of the ABCA subfamily that shows a high degree of homology to ABCA1 and, like ABCA1, mediates cellular cholesterol and phospholipid release by apolipoproteins when transfected in vitro...
  12. pmc Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans
    Christiane Reitz
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, Columbia University, 630 W 168th St, New York, NY 10032, USA
    JAMA 309:1483-92. 2013
    ..Identification of disease-associated variants helps identify targets for genetic testing, prevention, and treatment...
  13. doi Family quality of life and psychological well-being in parents of children with autism spectrum disorders: a double ABCX model
    P Pozo
    Faculty of Psychology, UNED National University for Distance Education, Madrid, Spain
    J Intellect Disabil Res 58:442-58. 2014
    ..The proposed model was based on the double ABCX model, with severity of the disorder, behaviour problems, social support, sense of coherence (SOC) and coping ..
  14. pmc Rare-variant extensions of the transmission disequilibrium test: application to autism exome sequence data
    Zongxiao He
    Center for Statistical Genetics, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Hum Genet 94:33-46. 2014
    ..exome data from 199 Simons Simplex Collection autism trios and an association was observed with variants in ABCA7. Given the problem of adequately controlling for population substructure and admixture in RV association studies ..
  15. pmc Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease
    Lei Yu
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, Illinois2Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois
    JAMA Neurol 72:15-24. 2015
    ....
  16. doi A comparison of White and Hispanic women's stories of adjustment to the birth of a child
    Sara E Pollard
    University of North Texas
    Infant Ment Health J 35:193-209. 2014
    ..of qualitative interviews led to the integration of Belsky's Determinants of Parenting Model (1984) and the Double ABCX Model of Family Adjustment and Adaptation (McCubbin & Patterson, 1983) into a hybrid third theoretical ..
  17. doi Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease
    Stacy Steinberg
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 47:445-7. 2015
    ..We found that loss-of-function variants in ABCA7 confer risk of Alzheimer's disease in Icelanders (odds ratio (OR) = 2.12, P = 2...
  18. pmc ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing
    Kanayo Satoh
    From the Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario M5T 2S8, Canada
    J Biol Chem 290:24152-65. 2015
    The ATP-binding cassette transporter A7 (ABCA7) has been identified as a susceptibility factor of late onset Alzheimer disease in genome-wide association studies...
  19. doi Family Adaptation to Stroke: A Metasynthesis of Qualitative Research based on Double ABCX Model
    Ali Hesamzadeh
    Department of Nursing, The University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
    Asian Nurs Res (Korean Soc Nurs Sci) 9:177-84. 2015
    ..interpretive review of research into subjective experience of families with stroke survivors based on the components of the Double ABCX Model including stressors, resources, perception, coping strategies, and adaptation of these families.
  20. doi Understanding the function of ABCA7 in Alzheimer's disease
    Hongyun Li
    Illawarra Health and Medical Research Institute, University of Wollongong, NSW 2522, Australia School of Biological Sciences, University of Wollongong, NSW 2522, Australia
    Biochem Soc Trans 43:920-3. 2015
    ATP-binding cassette transporter A7 (ABCA7) is highly expressed in the brain. Recent genome-wide association studies (GWAS) identify ABCA7 single nt polymorphisms (SNPs) that increase Alzheimer's disease (AD) risk...
  21. ncbi Molecular Basis of Familial and Sporadic Alzheimer's Disease
    Jolanta Dorszewska
    Laboratory of Neurobiology, Department of Neurology, Poznan University of Medical Sciences, 49, Przybyszewskiego st, 60 355 Poznan, Poland
    Curr Alzheimer Res 13:952-63. 2016
    ..molecular factors related to the immunological cause (TREM2) of the disease are a disorder of the lipid (ABCA1, ABCA7) or biothiol (MTHFD1) metabolism and of the transport of metabolites (BIN1)...
  22. pmc ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology
    Nobutaka Sakae
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224
    J Neurosci 36:3848-59. 2016
    ..b>ABCA7 is homologous to a major lipid transporter ABCA1 and is highly expressed in neurons and microglia in the brain...
  23. pmc ABCA7 rare variants and Alzheimer disease risk
    Kilan Le Guennec
    From INSERM K L G, G N, O Q, C C, D W, S R, A C R, A R L, T F, D H, D C, U1079, IRIB, University of Rouen, Normandy University Normandy Centre for Genomic Medicine and Personalized Medicine K L G, G N, O Q, C C, D W, S R, A C R, A R L, T F, D H, D C, Rouen Department of Genetics G N, T F, D H, CNR MAJ G N, O Q, C C, D W
    Neurology 86:2134-7. 2016
    To study the association between ABCA7 rare coding variants and Alzheimer disease (AD) in a case-control setting.
  24. pmc Overlap between Parkinson disease and Alzheimer disease in ABCA7 functional variants
    Karen Nuytemans
    John P Hussman Institute for Human Genomics and The Morris K Udall Parkinson Disease Center of Excellence, Miller School of Medicine, University of Miami, FL
    Neurol Genet 2:e44. 2016
    Given their reported function in phagocytosis and clearance of protein aggregates in Alzheimer disease (AD), we hypothesized that variants in ATP-binding cassette transporter A7 (ABCA7) might be involved in Parkinson disease (PD).
  25. pmc ABCA7 frameshift deletion associated with Alzheimer disease in African Americans
    HOLLY N CUKIER
    John P Hussman Institute for Human Genomics H N C, B W K, S R, K L H N, M A K, P L W, D V B, D M D, M L C, J M V, J R G, G W B, E R M, R M C, M A P V, Department of Neurology H N C, J M V, M A P V, Dr John T Macdonald Foundation Department of Human Genetics D M D, M L C, J M V, J R G, G W B, E R M, R M C, Miller School of Medicine, University of Miami, FL The Taub Institute for Research on Alzheimer s Disease and the Aging Brain B N V, R M, Gertrude H Sergievsky Center, Departments of Neurology, Psychiatry, and Epidemiology, Department of Dermatology
    Neurol Genet 2:e79. 2016
    To identify a causative variant(s) that may contribute to Alzheimer disease (AD) in African Americans (AA) in the ATP-binding cassette, subfamily A (ABC1), member 7 (ABCA7) gene, a known risk factor for late-onset AD.
  26. doi Genetic Variations in ABCA7 Can Increase Secreted Levels of Amyloid-β40 and Amyloid-β42 Peptides and ABCA7 Transcription in Cell Culture Models
    Michelle Bamji-Mirza
    Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada
    J Alzheimers Dis 53:875-92. 2016
    Alzheimer's disease (AD) is characterized by extracellular deposits of amyloid-β (Aβ) in the brain. ABCA7 is highly expressed in the brain and a susceptibility gene for late-onset AD (LOAD)...
  27. doi Mental health and positive change among Japanese mothers of children with intellectual disabilities: Roles of sense of coherence and social capital
    Miyako Kimura
    Department of Preventive Medicine, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki shi, Kanagawa 216 8511, Japan Electronic address
    Res Dev Disabil 59:43-54. 2016
    ..change among mothers of children with intellectual disabilities in Japan based on the concept of the Double ABCX model...
  28. doi Fine-mapping the effects of Alzheimer's disease risk loci on brain morphology
    Gennady V Roshchupkin
    Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands Department of Medical Informatics, Erasmus MC, Rotterdam, The Netherlands
    Neurobiol Aging 48:204-211. 2016
    ..Brain regions most significantly associated with AD risk variants were the left postcentral gyrus with ABCA7 (rs4147929, p = 4.45 × 10-6), right superior frontal gyrus by ZCWPW1 (rs1476679, p = 5...
  29. ncbi Perceived Stress and Social Adaptation of the Primary Caregivers of Children with Intellectual Disabilities
    Mohd Ashik Shahrier
    University of Rajshahi Bangladesh
    Span J Psychol 19:E87. 2016
    The study aimed to explore whether McCubbin and Patterson's Double ABCX model of stress and adaptation can promote a better understanding of the impacts of social support, definition of the stressor and coping strategies on stress and ..
  30. doi Computational Screening and Exploration of Disease-Associated Genes in Alzheimer's Disease
    Salma Jamal
    Department of Bioscience and Biotechnology, Banasthali University, Tonk, Rajasthan, India
    J Cell Biochem . 2016
    ..methods to examine the pathogenic effects of non-synonymous single nucleotide polymorphisms (SNPs) associated with ABCA7, CR1, MS4A6A, CD2AP, PSEN1, PSEN2, and APP genes...
  31. doi From Common to Rare Variants: The Genetic Component of Alzheimer Disease
    Gael Nicolas
    CNR MAJ, Rouen University Hospital, Rouen, France
    Hum Hered 81:129-141. 2016
    ..01) in the SORL1 and ABCA7 genes associated with a moderate relative risk (OR approximately 5 and approximately 2.8, respectively)...
  32. doi Association of GWAS Top Genes With Late-Onset Alzheimer's Disease in Colombian Population
    Diana Jennifer Moreno
    1 Grupo de Genética Molecular, Universidad de Antioquia, Medellin, Colombia
    Am J Alzheimers Dis Other Demen . 2016
    The association of variants in CLU, CR1, PICALM, BIN1, ABCA7, and CD33 genes with late-onset Alzheimer's disease (LOAD) was evaluated and confirmed through genome-wide association study...
  33. pmc Markers of cholesterol transport are associated with amyloid deposition in the brain
    Timothy M Hughes
    Department of Internal Medicine, School of Medicine, Wake Forest University, Winston Salem, NC, USA Electronic address
    Neurobiol Aging 35:802-7. 2014
    ..01), and lower plasma ApoE levels (p = 0.02), and variation in the ABCA7 (p = 0.02) and EPHA1 genes (p = 0.02)...
  34. ncbi Serum amyloid A generates high density lipoprotein with cellular lipid in an ABCA1- or ABCA7-dependent manner
    Sumiko Abe-Dohmae
    Biochemistry, Cell Biology, and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Lipid Res 47:1542-50. 2006
    ..SAA reacted with the HEK293-derived clones that stably express human ABCA1 (293/2c) or ABCA7 (293/6c) to generate cholesterol-containing HDL in a similar manner to apoA-I...
  35. doi Marriage and family therapists working with couples who have children with autism
    Julie Ramisch
    Family and Child Ecology, Michigan State University, East Lansing, MI 48824, USA
    J Marital Fam Ther 38:305-16. 2012
    Current research about families and couples who have children with autism is discussed using the Double ABCX model as a guide...
  36. doi Maladaptive behaviors of children with autism: parent support, stress, and coping
    Heather R Hall
    University of South Alabama, Mobile, Alabama 36688, USA
    Issues Compr Pediatr Nurs 35:194-214. 2012
    ..Autism Spectrum Disorders are nearly five times more common among boys than girls. Children with autism may develop a variety of socially unacceptable maladaptive behaviors beyond the defining symptoms of the spectrum disorder...
  37. pmc Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains
    Celeste M Karch
    Department of Psychiatry and Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA
    PLoS ONE 7:e50976. 2012
    ..Large-scale genome wide association studies (GWAS) for LOAD have identified 10 novel risk genes: ABCA7, BIN1, CD2AP, CD33, CLU, CR1, EPHA1, MS4A6A, MS4A6E, and PICALM...
  38. doi Association of GWAS-linked loci with late-onset Alzheimer's disease in a northern Han Chinese population
    Lan Tan
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, PR China
    Alzheimers Dement 9:546-53. 2013
    ..recently identified and confirmed 9 novel Alzheimer's disease (AD) susceptibility loci (CLU, CR1, PICALM, BIN1, ABCA7, MS4A gene cluster, CD2AP, CD33, and EPHA1)...
  39. pmc Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci
    Patrick Holton
    Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK
    Ann Hum Genet 77:85-105. 2013
    Recent genome wide association studies have identified CLU, CR1, ABCA7 BIN1, PICALM and MS4A6A/MS4A6E in addition to the long established APOE, as loci for Alzheimer's disease...
  40. ncbi ABC proteins: key molecules for lipid homeostasis
    Kei Takahashi
    Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Faculty of Agriculture, Kyoto University, Kitashirakawa, Sakyo ku, Japan
    Med Mol Morphol 38:2-12. 2005
    ..ABCA1 and ABCA7 mediate the apolipoprotein-dependent formation of a high-density lipoprotein-cholesterol complex...
  41. ncbi Detection of ABCA7-positive cells in salivary glands from patients with Sjögren's syndrome
    Yoshinobu Toda
    Center for Anatomical Studies, Graduate School of Medicine, Kyoto University, Japan
    Pathol Int 55:639-43. 2005
    b>ABCA7 is a member of the subfamily A of adenosine triphosphate-binding cassette (ABC) proteins, and highly homologous to ABCA1, which mediates the release of cellular cholesterol and phospholipid to form high-density lipoprotein...
  42. pmc The genetics and neuropathology of Alzheimer's disease
    Gerard D Schellenberg
    Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6100, USA
    Acta Neuropathol 124:305-23. 2012
    ..far accomplished through single nucleotide polymorphism arrays, has revealed nine new genes implicated in AD risk (ABCA7, BIN1, CD33, CD2AP, CLU, CR1, EPHA1, MS4A4E/MS4A6A, and PICALM)...
  43. pmc Genome-wide association study of Alzheimer's disease
    M I Kamboh
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Transl Psychiatry 2:e117. 2012
    ..GWASs) have identified nine other genes/loci (CR1, BIN1, CLU, PICALM, MS4A4/MS4A6E, CD2AP, CD33, EPHA1 and ABCA7) for late-onset Alzheimer's disease (LOAD)...
  44. doi Association of GWAS top hits with late-onset Alzheimer disease in Korean population
    Sun Ju Chung
    Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Alzheimer Dis Assoc Disord 27:250-7. 2013
    ..We selected 86 single-nucleotide polymorphisms (SNPs) selected from 12 genes (ABCA7, APOE, BIN1, CD2AP, CD33, CLU, CR1, EPHA1, LRAT, MS4A6A, PCDH11X, and PICALM) and genotyped in 290 AD cases and ..
  45. pmc Role of Abca7 in mouse behaviours relevant to neurodegenerative diseases
    Warren Logge
    Neuroscience Research Australia, Randwick, Australia
    PLoS ONE 7:e45959. 2012
    ..Recent studies suggest that the ABC transporter ABCA7 may play a role in the development of brain disorders such as schizophrenia and Alzheimer's disease...
  46. pmc Allele-specific polymerase chain reaction for the detection of Alzheimer's disease-related single nucleotide polymorphisms
    Mohd Nazif Darawi
    Brain Science Research Laboratory, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam, Selangor, 42300, Malaysia
    BMC Med Genet 14:27. 2013
    ..apolipoprotein E such as bridging integrator (BIN1), clusterin (CLU), ATP-binding cassette sub-family A member 7 (ABCA7), complement receptor 1 (CR1) and phosphatidylinositol binding clathrin assembly protein (PICALM)...
  47. pmc Identifying gene locus associations with promyelocytic leukemia nuclear bodies using immuno-TRAP
    Reagan W Ching
    Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Cell Biol 201:325-35. 2013
    ..a TP53 gene-PML NB association, immuno-TRAP allowed us to uncover novel locus-PML NB associations, including the ABCA7 and TFF1 loci and, most surprisingly, the PML locus itself...
  48. pmc Interaction between two cholesterol metabolism genes influences memory: findings from the Wisconsin Registry for Alzheimer's Prevention
    Corinne D Engelman
    Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA
    J Alzheimers Dis 36:749-57. 2013
    ..Interactions between the APOE ε4 allele and both of the genotyped ABCA7 SNPs, rs3764650 and rs3752246, were associated with all three cognitive factor scores (p-values ≤ 0.01)...
  49. doi Alzheimer's disease and Parkinson's disease genome-wide association study top hits and risk of Parkinson's disease in Korean population
    Sun Ju Chung
    Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Neurobiol Aging 34:2695.e1-7. 2013
    ..We selected 25 single nucleotide polymorphisms (SNPs) in 9 genes (ABCA7, APOE, BST1, CLU, CR1, LRRK2, PARK16, PICALM, and SNCA) that were genotyped in 1036 PD case patients and 1208 ..
  50. pmc Genetic susceptibility for Alzheimer disease neuritic plaque pathology
    Joshua M Shulman
    Departments of Neurology and Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas2Jan and Dan Duncan Neurological Research Institute, Texas Children s Hospital, Houston
    JAMA Neurol 70:1150-7. 2013
    ..While numerous genetic susceptibility loci have been identified for clinical Alzheimer disease (AD), it is important to establish whether these variants are risk factors for the underlying disease pathology, including neuritic plaques...
  51. pmc ABCA7 expression is associated with Alzheimer's disease polymorphism and disease status
    Jared B Vasquez
    Department of Physiology, Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, United States
    Neurosci Lett 556:58-62. 2013
    ..SNPs within the gene ATP binding cassette A7 (ABCA7) reached significance in these studies, warranting investigation into their actions...
  52. ncbi Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7)
    W E Kaminski
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, Regensburg, D 93042, Germany
    Biochem Biophys Res Commun 273:532-8. 2000
    ..In accordance with the currently proposed classification, the novel transporter was designated ABCA7. ABCA7 mRNA was detected predominantly in myelo-lymphatic tissues with highest expression in peripheral leukocytes,..
  53. ncbi Affinity selection of cDNA libraries by lambda phage surface display
    M Niwa
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Gene 256:229-36. 2000
    ..Thus, the bacteriophage lambda surface display is powerful for isolating cDNA clones by affinity screening...
  54. ncbi Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene
    W E Kaminski
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, Regensburg, D 93042, Germany
    Biochem Biophys Res Commun 278:782-9. 2000
    We have recently cloned a novel cholesterol-responsive ABC transporter, designated ABCA7, which is predominantly expressed in human leukocytes. Here we report the structure of the human ABCA7 gene...
  55. ncbi Complete coding sequence, promoter region, and genomic structure of the human ABCA2 gene and evidence for sterol-dependent regulation in macrophages
    W E Kaminski
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, 93042, Germany
    Biochem Biophys Res Commun 281:249-58. 2001
    ..ABCA2 shares highest homology with the cholesterol-responsive transporters ABCA1 (50%) and the recently cloned ABCA7 (44%). The ABCA2 gene comprises 48 exons which are localized within a genomic region of only 21 kb...
  56. ncbi Short-term memory for serial order in schizophrenia: a detailed examination of error types
    B Elvevåg
    Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Neuropsychology 15:128-35. 2001
    ..g., ABCD being recalled as ABDC) or intrusion errors (e.g., ABCD being recalled as ABCX), whereas simple trace decay would lead to omission errors (e.g., ABCD being recalled as ABC_)...
  57. ncbi Human ABCA1 contains a large amino-terminal extracellular domain homologous to an epitope of Sjögren's Syndrome
    A R Tanaka
    Laboratory of Biochemistry, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, 606 8502, Japan
    Biochem Biophys Res Commun 283:1019-25. 2001
    ..We found that this amino-terminal extracellular domain contains a segment homologous to the autoantigen SS-N, an epitope of Sjögren's syndrome, and further identified that ABCA7 codes for the autoantigen SS-N.
  58. ncbi Comparative analysis of the promoter structure and genomic organization of the human and mouse ABCA7 gene encoding a novel ABCA transporter
    C Broccardo
    Centre d Immunologie INSERM CNRS de Marseille Luminy, Marseille, France
    Cytogenet Cell Genet 92:264-70. 2001
    ..genomic and transcriptional characterization in mouse and man of a novel transporter of the ABCA subclass, named ABCA7. As it is the case for other ABCA genes, the predicted protein encoded by ABCA7 is a full symmetric transporter, ..
  59. ncbi Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8
    Aritoshi Iida
    Laboratory for Genotyping, RIKEN SNP Research Center, Tokyo, Japan
    J Hum Genet 47:285-310. 2002
    ..additional loci, specifically 13 genes belonging to the superfamily of ATP-binding cassette transporters ( ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8)...
  60. ncbi Gender differences in adapting to a child's chronic illness: a causal model
    Shira Katz
    Nursing Department, Tel Aviv University, Ramat Aviv, Israel
    J Pediatr Nurs 17:257-69. 2002
    ..variables contributing to their adaptation and (2) the suitability of the causal model based on the Double ABCX Model to predict parents' adaptation to the child's illness...
  61. ncbi Chromosomal localization of genes involved in biosynthesis, metabolism or transport of cholesterol in the rat
    A C M Bonné
    Department of Laboratory Animal Science, Veterinary Faculty, Utrecht University, Utrecht, The Netherlands
    Cytogenet Genome Res 97:183-6. 2002
    ..for phospholipid transfer protein (Pltp), sterol carrier protein-2 (Scp2), ATP binding cassette reporter A7 (Abca7), scavenger receptor class B, type 1 (Cd36l1), steroidogenic acute regulatory protein (Star), and lecithin:..
  62. ncbi Cloning of rat ABCA7 and its preferential expression in platelets
    Mari Sasaki
    Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567 0047, Japan
    Biochem Biophys Res Commun 304:777-82. 2003
    We cloned the full-length cDNA of a rat orthologue of ABCA7 (rABCA7) from rat platelets. The cDNA of rABCA7 is 6510bp in length and encodes a protein of 2170 amino acids...
  63. ncbi Explaining the parental stress of fathers and mothers caring for a child with intellectual disability: a Double ABCX Model
    T Saloviita
    Department of Special Education, University of Jyvaskyla, Jyvaskyla, Finland
    J Intellect Disabil Res 47:300-12. 2003
    Twenty variables based on the Double ABCX Model of adaptation and selected on the basis of previous research were chosen to explain the parental stress of the mothers (n = 116) and fathers (n = 120) of children with an intellectual ..
  64. ncbi ST segment resolution in ASSENT 3: insights into the role of three different treatment strategies for acute myocardial infarction
    Paul W Armstrong
    University of Alberta, Edmonton, Canada
    Eur Heart J 24:1515-22. 2003
    ..demonstrated that the bolus fibrinolytic tenecteplase (TNK), combined with enoxaparin (ENOX) or abciximab (ABCX), substantially reduced ischemic complications of acute myocardial infarction as compared with unfractionated ..
  65. ncbi Adenosine triphosphate binding cassette (ABC) transporters are expressed and regulated during terminal keratinocyte differentiation: a potential role for ABCA7 in epidermal lipid reorganization
    Danuta Kielar
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, D 93042 Regensburg, Germany
    J Invest Dermatol 121:465-74. 2003
    ..The recently cloned transporter ABCA7 was highly expressed in keratinocytes and HaCaT cells and upregulated during differentiation...
  66. ncbi Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein
    Sumiko Abe-Dohmae
    Biochemistry, Molecular Biology and Metabolism 1, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Biol Chem 279:604-11. 2004
    ..cholesterol and phospholipids was induced in HEK293 cells by expressing human ATP-binding cassette transporter A7 (ABCA7) and ABC transporter A1 (ABCA1) proteins, whether transient or stable, to generate cholesterol-rich high density ..
  67. ncbi Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release
    Yuika Ikeda
    Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    Biochem Biophys Res Commun 311:313-8. 2003
    b>ABCA7 is expressed predominantly in myelo-lymphatic tissues or reticuloendothelial cells. Physiological role and function of this protein are not fully understood...
  68. ncbi Korean mothers' psychosocial adjustment to their children's cancer
    Hae Ra Han
    School of Nursing, The Johns Hopkins University, Baltimore, Maryland 21205 2110, USA
    J Adv Nurs 44:499-506. 2003
    ..Although parental adjustment has been a research topic for many years, little research has been conducted among families in different cultures and countries...
  69. ncbi Finding meaning in parenting a child with Asperger syndrome: correlates of sense making and benefit finding
    Kenneth I Pakenham
    Behaviour Research and Therapy Centre, School of Psychology, The University of Queensland, Brisbane, QLD 4072, Australia
    Res Dev Disabil 25:245-64. 2004
    ..in parents of a child with Asperger syndrome, and examined relations between both meaning constructs and the Double ABCX family stress model variables (initial stressor and pile-up of demands, appraisal, social support, coping ..
  70. ncbi Predictors of the stage of residential planning among aging families of adults with severe mental illness
    Gregory C Smith
    School of Family and Consumer Studies, Kent State University, 144 Nixson Hall, Kent, OH 44242, USA
    Psychiatr Serv 55:804-10. 2004
    This study identified predictors of the extent of residential planning carried out by aging families of adults with severe mental illness according to the conceptual framework of the Double ABCX model of family coping and adaptation.
  71. ncbi ATP-binding cassette transporter A1 contains a novel C-terminal VFVNFA motif that is required for its cholesterol efflux and ApoA-I binding activities
    Michael L Fitzgerald
    Lipid Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 279:48477-85. 2004
    ..Chimeric transporters, generated by substituting the C termini of either ABCA4 or ABCA7 for the endogenous terminus, demonstrated that ABCA1 could stimulate cholesterol efflux without its PDZ-binding ..
  72. ncbi Potential role of ABCA7 in cellular lipid efflux to apoA-I
    Patrick Linsel-Nitschke
    Division of Molecular Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Lipid Res 46:86-92. 2005
    b>ABCA7 is homologous to ABCA1 and has recently been shown in cell culture to bind apolipoprotein A-I (apoA-I) and to promote the efflux of phospholipids. However, it is not known if ABCA7 promotes lipid efflux in vivo...
  73. ncbi Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels
    Woojin Scott Kim
    Lipid Metabolism Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 280:3989-95. 2005
    ..Although the functions of the other 10 ABCA class transporters identified in the human genome remain obscure, ABCA7-transfected cells have been shown to efflux lipids in response to stimulation by apolipoprotein A-I...
  74. ncbi Homozygosity for the 168His variant of the minor histocompatibility antigen HA-1 is associated with reduced risk of primary Sjögren's syndrome
    Mariann Harangi
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, D 93042 Regensburg, Germany
    Eur J Immunol 35:305-17. 2005
    The genes for the human ATP-binding cassette (ABC) transporter ABCA7 and the minor histocompatibility antigen HA-1 are juxtaposed in close proximity on chromosome 19p13.3...
  75. ncbi Empowerment in parents of school-aged children with and without developmental disabilities
    J S Nachshen
    Queen s University, Department of Psychology, Kingston, Ontario, Canada
    J Intellect Disabil Res 49:889-904. 2005
    ..This study examined the factors that contribute to empowerment in parents of school-aged children with and without developmental disabilities (DD) using the Double ABCX model of family adaptation contrasted with the linear ACBX model.
  76. ncbi Left ventricular remodeling after primary coronary angioplasty in patients treated with abciximab or intracoronary adenosine
    Anna S Petronio
    Cardiothoracic Department, University of Pisa, Pisa, Italy
    Am Heart J 150:1015. 2005
    ..Our aim was to evaluate the impact of abciximab and adenosine on immediate angiographic results and on 6-month left ventricular remodeling...
  77. ncbi ABCA7, a molecule with unknown function
    Sumiko Abe-Dohmae
    Biochemistry, Molecular Biology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Nagoya, Aichi 467 8601, Japan
    FEBS Lett 580:1178-82. 2006
    Many ABC proteins are functional in cellular lipid transport in various different manners. ABCA7 is a full-size ABC transporter, the physiological function of which is unknown to date...
  78. ncbi Acute digoxin loading reduces ABCA8A mRNA expression in the mouse liver
    Michi Wakaumi
    Department of Pharmacology, Division of Clinical Pharmacology, Jichi Medical School, Kawachi, Tochigi, Japan
    Clin Exp Pharmacol Physiol 32:1034-41. 2005
    ..Similar reductions in ABCA5, ABCA7, ABCA8b and ABCA9 mRNA were also observed...
  79. ncbi Quantitation of ATP-binding cassette subfamily-A transporter gene expression in primary human brain cells
    Woojin S Kim
    Prince of Wales Medical Research Institute, Randwick, New South Wales, Australia
    Neuroreport 17:891-6. 2006
    Five ATP-binding cassette (ABC) subfamily-A transporters (ABCA1, ABCA2, ABCA3, ABCA7 and ABCA8) are expressed in the brain...
  80. ncbi ABCA7 expression is regulated by cellular cholesterol through the SREBP2 pathway and associated with phagocytosis
    Noriyuki Iwamoto
    Biochemistry, Cell Biology, and Metabolism 1, Nagoya City University, Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Lipid Res 47:1915-27. 2006
    b>ABCA7 is highly homologous to ABCA1 and mediates cellular cholesterol and phospholipid release by apolipoproteins when transfected in vitro...
  81. ncbi Individual and marital adaptation in men with autism spectrum disorder and their spouses: the role of social support and coping strategies
    Jo Renty
    Research Group Developmental Disorders, Department of Experimental Clinical and Health Psychology, Ghent University, Henri Dunantlaan 2, B 9000, Ghent, Belgium
    J Autism Dev Disord 37:1247-55. 2007
    ..and marital adaptation in adult men with autism spectrum disorder (ASD) and their spouses, based on the double ABCX model of adaptation...
  82. ncbi The ABCA2 transporter: intracellular roles in trafficking and metabolism of LDL-derived cholesterol and sterol-related compounds
    Jody T Mack
    Department of Cell and Molecular Pharmacology, Medical University of South Carolina, 173 Ashley Avenue, BSB303, P O Box 250505 Charleston, SC 29425 0001, USA
    Curr Drug Metab 8:47-57. 2007
    ..This transporter, along with other proteins that have a high degree of homology to ABCA2, including ABCA1 and ABCA7, are up-regulated in human macrophages during cholesterol import...
  83. ncbi [Stress in mothers of individuals with autistic spectrum disorders]
    Pilar Pozo Cabanillas
    Universidad Nacional de Educacion a Distancia, Madrid, Spain
    Psicothema 18:342-7. 2006
    ..We proposed a multi-factorial and global model based on the Double ABCX model of family stress (McCubbin & Patterson, 1983) in which, the factor aA (stressor) interacts with bB (..
  84. ncbi Correlation of induction of ATP binding cassette transporter A5 (ABCA5) and ABCB1 mRNAs with differentiation state of human colon tumor
    Sumio Ohtsuki
    Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Biol Pharm Bull 30:1144-6. 2007
    ..ABCA6 mRNA was detected in lung and liver, and ABCA8 was detected in lung. ABCA6, ABCA7 and ABCA8 mRNAs were not detected in any tumors, but weak mRNA expression of ABCA10 was detected in all tumors ..
  85. ncbi Mapping ATP-binding cassette transporter gene expression profiles in melanocytes and melanoma cells
    Susanne Heimerl
    Institute of Clinical Chemistry, University of Regensburg, Regensburg, Germany
    Melanoma Res 17:265-73. 2007
    ..ABCB3, ABCB6, ABCC2, ABCC4, ABCE1 and ABCF2 were significantly increased in melanoma cell lines, whereas ABCA7, ABCA12, ABCB2, ABCB4, ABCB5 and ABCD1 showed lower expression levels...
  86. pmc A novel method to quantify sphingosine 1-phosphate by immobilized metal affinity chromatography (IMAC)
    Yong Moon Lee
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030 3505, USA
    Prostaglandins Other Lipid Mediat 84:154-62. 2007
    ..also used to demonstrate that plasma S1P levels were not altered in mice deficient for ABC transporters, Abca1, Abca7 and Abcc1/Mrp1...
  87. doi ATP-binding cassette transporter A7 regulates processing of amyloid precursor protein in vitro
    Sharon L Chan
    Prince of Wales Medical Research Institute, Randwick, New South Wales, Australia
    J Neurochem 106:793-804. 2008
    ATP-binding cassette transporter A7 (ABCA7) is expressed in the brain and, like its closest homolog ABCA1, belongs to the ABCA subfamily of full-length ABC transporters...
  88. doi Differential expression of ABC transporters and their regulatory genes during lactation and dry period in bovine mammary tissue
    Carolin Farke
    Physiology Weihenstephan, Technical University Munich, 85354 Freising, Germany
    J Dairy Res 75:406-14. 2008
    ..Five ABC transporter genes, namely ABCA1, ABCA7, ABCG1, ABCG2 and ABCG5, their regulating genes LXRalpha, PPARgamma, SREBP1 and the milk proteins lactoferrin and ..
  89. pmc ATP-binding cassette transporters ABCA1, ABCA7, and ABCG1 in mouse spermatozoa
    Carlos R Morales
    Department of Anatomy and Cell Biology, McGill University, Montreal, Que, Canada H3A2B2
    Biochem Biophys Res Commun 376:472-7. 2008
    ..Candidate transporters are members of the ATP-binding cassette (ABC) transporter superfamily including ABCA1, ABCA7, ABCG1 and ABCG4, which have all been implicated in the transport of sterols and phospholipids to apolipoproteins ..
  90. pmc Defective CFTR increases synthesis and mass of sphingolipids that modulate membrane composition and lipid signaling
    Hiroko Hamai
    Department of Pathology, Columbia University, New York, NY 10032, USA
    J Lipid Res 50:1101-8. 2009
    ..synthesis and mass, whereas overexpression of wild-type CFTR, but not of an unrelated ABC transporter, ABCA7, decreases sphingolipid synthesis and mass...
  91. doi Characterization of the ATP-binding cassette transporter gene expression profile in Y79: a retinoblastoma cell line
    Doris Hendig
    Institut fur Laboratoriums und Transfusionsmedizin, Herz und Diabeteszentrum Nordrhein Westfalen, Universitatsklinik der Ruhr Universitat Bochum, Bad Oeynhausen, Germany
    Mol Cell Biochem 328:85-92. 2009
    ..Y79 cells demonstrate high gene expression of ABCA7, ABCA12, ABCB7, ABCB10, ABCC1, ABCC4, ABCD3, ABCE1, ABCF1, ABCF2, and ABCF3 (more than twofold compared to pooled ..
  92. doi Differential expression and localization of lipid transporters in the bovine mammary gland during the pregnancy-lactation cycle
    O Mani
    Institute of Biochemistry and Molecular Medicine, University of Bern, CH 3012 Bern, Switzerland
    J Dairy Sci 92:3744-56. 2009
    ..Blood serum metabolites were determined by common enzymatic chemistries. Elevated mRNA profiles of ABCA1 and ABCA7 were found during DP as compared with lactation and were inversely associated with blood cholesterol levels...
  93. pmc Apoptotic engulfment pathway and schizophrenia
    Xiangning Chen
    Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
    PLoS ONE 4:e6875. 2009
    ..In this study, we followed the apoptotic engulfment pathway involving the MEGF10, GULP1, ABCA1 and ABCA7 genes and tested their association with the disease.
  94. doi Knowledge for the good of the individual and society: linking philosophy, disciplinary goals, theory, and practice
    Mary K McCurry
    Department of Adult and Child Nursing, University of Massachusetts Dartmouth, North Dartmouth, MA 02747, USA
    Nurs Philos 11:42-52. 2010
    ..McCubbin and Patterson's Double ABCX Model of Family Adaptation was used as an example of a theory that can guide practice at the community and global ..
  95. ncbi Maternal coping and adaptation: A case study examination of chronic sorrow in caring for an adolescent with a progressive neurodegenerative disease
    Amanda M E Bettle
    IWK Health Centre, Halifax, NS
    Can J Neurosci Nurs 31:15-21. 2009
    ..McCubbin and Patterson's (1983) Double ABCX model of Adjustment and Adaptation was used to explore ongoing maternal coping and adaptation...
  96. doi Expression of ABC-type transport proteins in human platelets
    Juliane Niessen
    Department of Pharmacology, Research Center of Pharmacology and Experimental Therapeutics, Ernst Moritz Arndt University, Greifswald, Germany
    Pharmacogenet Genomics 20:396-400. 2010
    ..On the protein level ABCA7, ABCB4, ABCC1, ABCC3 and ABCC4 were identified by liquid chromatography/MS/MS and localized by immunofluorescence ..
  97. doi Expression, localization, and functional model of cholesterol transporters in lactating and nonlactating mammary tissues of murine, bovine, and human origin
    Orlando Mani
    Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland
    Am J Physiol Regul Integr Comp Physiol 299:R642-54. 2010
    ..lipid homeostasis and mammary gland (MG) physiology, we compared expression and localization of ABCA1, ABCG1, and ABCA7 and their regulatory genes in mammary tissues of different species during the pregnancy-lactation cycle...
  98. pmc Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7
    Nobukiyo Tanaka
    Department of Biochemistry, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Lipid Res 51:2591-9. 2010
    ..Therefore we investigated the molecular basis of this reaction in association with the function of ABCA7. Similar to ABCA1, ABCA7 was degraded, likely by calpain, and apoA-I and apoA-II stabilize ABCA7 against ..
  99. doi The double ABCX model of adaptation in racially diverse families with a school-age child with autism
    Margaret M Manning
    Department of Psychology, University of Massachusetts Boston, Boston, MA 02452, USA
    J Autism Dev Disord 41:320-31. 2011
    In this study, the Double ABCX model of family adaptation was used to explore the impact of severity of autism symptoms, behavior problems, social support, religious coping, and reframing, on outcomes related to family functioning and ..
  100. doi Postflood disaster management and the home health nurse: using theory to guide practice
    Susan M Hunter Revell
    Department of Adult and Child Nursing, College of Nursing, University of Massachusetts Dartmouth, North Dartmouth, Massachusetts 02747, USA
    J Community Health Nurs 27:126-36. 2010
    ..The Double ABCX Model of Family Adaptation is offered as an example of a guiding framework for nurses in postflood management...

Research Grants11

  1. CRAIG STEPHEN ATWOOD; Fiscal Year: 2014
    ..Importantly, APOE ?4, the major risk factor for AD, and ABCA7, recently associated with AD from GWAS, alter the neuronal transport of cholesterol, the precursor from which all ..
  2. Heba Nowyhed; Fiscal Year: 2015
    ..b>ABCA7, an adenosine triphosphate binding cassette transporter, has been shown to be upregulated in immune cells in ..
  3. Richard P Mayeux; Fiscal Year: 2016
    ..of these newly identified genetic risk factors, namely SNPs in PICALM, CLU, BIN1, MS4A gene clusters, CD33, CD2AP, ABCA7 and EPHA1 using the multiplex families recruited through the National Institute on Aging-Late Onset Alzheimer'..
  4. M Ilyas Kamboh; Fiscal Year: 2016
    ..studies (GWAS) have identified significant associations of LOAD with SNPs in nine additional loci, including, ABCA7, MS4A4, EPHA1, CLU, CR1, PICALM, BIN1, CD2AP and CD33 and all, but CR1 and CD2AP, have been replicated in our GWAS ..
  5. ABCA7: Cellular Functions and Role in Atherosclerosis
    Alan Tall; Fiscal Year: 2009
    b>ABCA7 and ABCA1 are related ABC transporters that have been proposed to function in cellular lipid efflux and in phagocytosis of apoptotic cells...
  6. GENOMIC ANALYSIS OF ALZHEIMERS DISEASE GENES
    Gerard Schellenberg; Fiscal Year: 2002
    ..A fifth goal is to refine the location of additional AD loci using Monte Carlo simulation methods for analysis of family data. ..
  7. Cloning of Late-onset Alzheimer's Disease Genes
    Gerard Schellenberg; Fiscal Year: 2007
    ..For type specifications, see instructions on pages.) RESEARCHGRANT TABLE OF CONTENTS Page Numbers Face Page _ .-. '. _....'. _ 1 Description, ..
  8. 4/5-Elucidating the Genetic Architecture of Autism by Deep Genomic Sequencing
    GERARD DAVID SCHELLENBERG; Fiscal Year: 2010
    ..abstract_text> ..
  9. Stress, Coping, and Well-Being of Custodial Grandparents
    Gregory Smith; Fiscal Year: 2003
    ..Aim 5 is to archive the data for eventual use by other researchers; The findings of this study will inform the development of interventions tailored to assist custodial grandparents and their families. ..
  10. Better Breast Health for Korean American Women
    Hae Ra Han; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  11. Online Intervention to Improve Stroke Care From Spouses
    Gregory Smith; Fiscal Year: 2007
    ..Prior psychosocial intervention research with informal stroke CGs has been scarce, equivocal in findings, methodologically flawed, and without theoretical foundation. [unreadable] [unreadable] [unreadable]..