ABCA1

Summary

Gene Symbol: ABCA1
Description: ATP binding cassette subfamily A member 1
Alias: ABC-1, ABC1, CERP, HDLDT1, TGD, ATP-binding cassette sub-family A member 1, ATP-binding cassette transporter A1, ATP-binding cassette, sub-family A (ABC1), member 1, cholesterol efflux regulatory protein, membrane-bound
Species: human

Top Publications

  1. pmc HIV-1 Nef mobilizes lipid rafts in macrophages through a pathway that competes with ABCA1-dependent cholesterol efflux
    Huanhuan L Cui
    Baker Heart and Diabetes Institute, Melbourne, Vic, Australia
    J Lipid Res 53:696-708. 2012
  2. ncbi Genetic variation in ABCA1 predicts ischemic heart disease in the general population
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Arterioscler Thromb Vasc Biol 28:180-6. 2008
  3. ncbi Interleukin-10 inhibits the down-regulation of ATP binding cassette transporter A1 by tumour necrosis factor-alpha in THP-1 macrophage-derived foam cells
    Chun li Mei
    Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jie Fang Avenue, Wuhan, Hubei Province 430022, China
    Cell Biol Int 31:1456-61. 2007
  4. pmc ATP-binding cassette A1-mediated lipidation of apolipoprotein A-I occurs at the plasma membrane and not in the endocytic compartments
    Maxime Denis
    Ottawa Health Research Institute, and Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ontario K1Y 4E9, Canada
    J Biol Chem 283:16178-86. 2008
  5. pmc Niacin increases HDL biogenesis by enhancing DR4-dependent transcription of ABCA1 and lipidation of apolipoprotein A-I in HepG2 cells
    Lin Hua Zhang
    Atherosclerosis Research Center, Veterans Affairs Healthcare System, Long Beach, CA, USA
    J Lipid Res 53:941-50. 2012
  6. ncbi Molecular and cellular physiology of apolipoprotein A-I lipidation by the ATP-binding cassette transporter A1 (ABCA1)
    Maxime Denis
    Cardiovascular Genetics Laboratory, Cardiology Division, McGill University Health Center, Royal Victoria Hospital, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 279:7384-94. 2004
  7. doi Relationships between common polymorphisms of adenosine triphosphate-binding cassette transporter A1 and high-density lipoprotein cholesterol and coronary heart disease in a population with type 2 diabetes mellitus
    Isabelle Porchay-Baldérelli
    INSERM U695, Genetic Determinants for Type 2 Diabetes and Its Vascular Complications, Xavier Bichat Medical School, 16 rue Henri Huchard, 75018 Paris, France
    Metabolism 58:74-9. 2009
  8. pmc Cardioprotective role of the mitochondrial ATP-binding cassette protein 1
    Hossein Ardehali
    Division of Cardiology, Feinberg Cardiovascular Institute, Northwestern University, Chicago, Ill, USA
    Circ Res 97:740-2. 2005
  9. doi The influence of two variants in the adenosine triphosphate-binding cassette transporter 1 gene on plasma lipids and carotid atherosclerosis
    Anton Sandhofer
    Department of Internal Medicine I, Innsbruck Medical University, Innsbruck, Austria
    Metabolism 57:1398-404. 2008
  10. ncbi Advanced glycation end product precursors impair ABCA1-dependent cholesterol removal from cells
    Marisa Passarelli
    Department of Medicine, Box 356426, University of Washington, Seattle, WA 98195 6426, USA
    Diabetes 54:2198-205. 2005

Research Grants

  1. Anti-inflammatory, cholesterol export, and cardioprotective functions of ABCA1
    Renee C LeBoeuf; Fiscal Year: 2013
  2. Membrane biophysics of enterotoxin mediated immunomodulation
    Arnd Pralle; Fiscal Year: 2013
  3. MATTHEW LAWRENCE WILLIAMS; Fiscal Year: 2014
  4. Subtype Specific LXR Activity Limits Atherosclerosis
    Ira G Schulman; Fiscal Year: 2013
  5. Multicolor Cell Membrane Profiling For Development And Disease
    BRIAN DAVID GRAY; Fiscal Year: 2013
  6. A Novel Approach to Identify HIV Suppression Factor from CD8 Cells
    Phalguni Gupta; Fiscal Year: 2010
  7. ALAN RICHARD TALL; Fiscal Year: 2016
  8. Mei Hong; Fiscal Year: 2016
  9. Anjali Ganda; Fiscal Year: 2016
  10. Microfluidic Processors for Directed Evolution and Synthetic Biology
    Brian M Paegel; Fiscal Year: 2011

Detail Information

Publications331 found, 100 shown here

  1. pmc HIV-1 Nef mobilizes lipid rafts in macrophages through a pathway that competes with ABCA1-dependent cholesterol efflux
    Huanhuan L Cui
    Baker Heart and Diabetes Institute, Melbourne, Vic, Australia
    J Lipid Res 53:696-708. 2012
    HIV infection, through the actions of viral accessory protein Nef, impairs activity of cholesterol transporter ABCA1, inhibiting cholesterol efflux from macrophages and elevating the risk of atherosclerosis...
  2. ncbi Genetic variation in ABCA1 predicts ischemic heart disease in the general population
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Arterioscler Thromb Vasc Biol 28:180-6. 2008
    We tested the hypothesis that 6 nonsynonymous single nucleotide polymorphisms (SNPs) in ATP-Binding-Cassette transporter A1 (ABCA1) affect risk of ischemic heart disease (IHD) in the general population.
  3. ncbi Interleukin-10 inhibits the down-regulation of ATP binding cassette transporter A1 by tumour necrosis factor-alpha in THP-1 macrophage-derived foam cells
    Chun li Mei
    Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jie Fang Avenue, Wuhan, Hubei Province 430022, China
    Cell Biol Int 31:1456-61. 2007
    It is suggested that cholesterol efflux mediated by ATP binding cassette transporter A1 (ABCA1) plays an important role in anti-atherogenesis...
  4. pmc ATP-binding cassette A1-mediated lipidation of apolipoprotein A-I occurs at the plasma membrane and not in the endocytic compartments
    Maxime Denis
    Ottawa Health Research Institute, and Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ontario K1Y 4E9, Canada
    J Biol Chem 283:16178-86. 2008
    ..This process is proposed to occur through a retro-endocytosis pathway in which apoA-I internalizes with ABCA1 and generates HDL from the endosomal compartments before resecretion...
  5. pmc Niacin increases HDL biogenesis by enhancing DR4-dependent transcription of ABCA1 and lipidation of apolipoprotein A-I in HepG2 cells
    Lin Hua Zhang
    Atherosclerosis Research Center, Veterans Affairs Healthcare System, Long Beach, CA, USA
    J Lipid Res 53:941-50. 2012
    ..Niacin dose-dependently stimulated the cell efflux of phospholipid and cholesterol and increased transcription of ABCA1 gene and ABCA1 protein...
  6. ncbi Molecular and cellular physiology of apolipoprotein A-I lipidation by the ATP-binding cassette transporter A1 (ABCA1)
    Maxime Denis
    Cardiovascular Genetics Laboratory, Cardiology Division, McGill University Health Center, Royal Victoria Hospital, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 279:7384-94. 2004
    The dynamics of ABCA1-mediated apoA-I lipidation were investigated in intact human fibroblasts induced with 22(R)-hydroxycholesterol and 9-cis-retinoic acid (stimulated cells)...
  7. doi Relationships between common polymorphisms of adenosine triphosphate-binding cassette transporter A1 and high-density lipoprotein cholesterol and coronary heart disease in a population with type 2 diabetes mellitus
    Isabelle Porchay-Baldérelli
    INSERM U695, Genetic Determinants for Type 2 Diabetes and Its Vascular Complications, Xavier Bichat Medical School, 16 rue Henri Huchard, 75018 Paris, France
    Metabolism 58:74-9. 2009
    ..The adenosine triphosphate-binding cassette transporter A1 (ABCA1) plays a key role in HDL metabolism...
  8. pmc Cardioprotective role of the mitochondrial ATP-binding cassette protein 1
    Hossein Ardehali
    Division of Cardiology, Feinberg Cardiovascular Institute, Northwestern University, Chicago, Ill, USA
    Circ Res 97:740-2. 2005
    ..These results support the notion that mABC1 protein plays a major role in cellular protection against oxidant stress, identifying mABC1 as a novel target for cardioprotective therapeutics...
  9. doi The influence of two variants in the adenosine triphosphate-binding cassette transporter 1 gene on plasma lipids and carotid atherosclerosis
    Anton Sandhofer
    Department of Internal Medicine I, Innsbruck Medical University, Innsbruck, Austria
    Metabolism 57:1398-404. 2008
    Variants in the adenosine triphosphate-binding-cassette transporter 1 (ABCA1) gene are known to affect high-density lipoprotein cholesterol and plasma triglycerides and the development of atherosclerosis...
  10. ncbi Advanced glycation end product precursors impair ABCA1-dependent cholesterol removal from cells
    Marisa Passarelli
    Department of Medicine, Box 356426, University of Washington, Seattle, WA 98195 6426, USA
    Diabetes 54:2198-205. 2005
    ..The ATP-binding cassette transporter A1 (ABCA1) is an atheroprotective cell protein that mediates cholesterol transport from cells to apolipoprotein (apo) A-I, ..
  11. doi Effects of ABCA1 variants on rosiglitazone monotherapy in newly diagnosed type 2 diabetes patients
    Jie Wang
    Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai 200233, China
    Acta Pharmacol Sin 29:252-8. 2008
    ..to investigate the relationship between R219K, M883I, and R1587K variants of the ATP-binding cassette transporter subfamily A number 1 (ABCA1) gene and response to rosiglitazone treatment in newly diagnosed patients with type 2 diabetes.
  12. ncbi Phosphorylation of a pest sequence in ABCA1 promotes calpain degradation and is reversed by ApoA-I
    Laurent O Martinez
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 278:37368-74. 2003
    ATP-binding cassette transporter A1 (ABCA1), the defective molecule in Tangier disease, mediates the apoAI-dependent efflux of excess cholesterol from cells...
  13. ncbi ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL
    Ashley M Vaughan
    Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, WA 98195 6426, USA
    J Lipid Res 47:2433-43. 2006
    ..b>ABCA1 mediates the transport of cholesterol and phospholipids from cells to lipid-poor apolipoprotein A-I (apoA-I), ..
  14. ncbi Glycosphingolipid accumulation inhibits cholesterol efflux via the ABCA1/apolipoprotein A-I pathway: 1-phenyl-2-decanoylamino-3-morpholino-1-propanol is a novel cholesterol efflux accelerator
    Elias N Glaros
    Centre for Vascular Research, University of New South Wales, Sydney, New South Wales 2052, Australia
    J Biol Chem 280:24515-23. 2005
    ..ApoA-I-mediated cholesterol efflux via ABCA1 (ATP-binding cassette transporter A1) is a key regulator of cellular cholesterol balance...
  15. pmc Mutation of the ATP cassette binding transporter A1 (ABCA1) C-terminus disrupts HIV-1 Nef binding but does not block the Nef enhancement of ABCA1 protein degradation
    Zahedi Mujawar
    Lipid Metabolism Unit, Center for Computational and Integrative Biology, Richard B Simches Research Center, Massachusetts General Hospital, 185 Cambridge Street, 7th Floor 7150, Boston, Massachusetts 02114, USA
    Biochemistry 49:8338-49. 2010
    ..The HIV-1 Nef protein can impair ATP cassette binding transporter A1 (ABCA1) cholesterol efflux from macrophages, a potentially pro-atherosclerotic effect...
  16. ncbi Phosphorylation by protein kinase CK2 modulates the activity of the ATP binding cassette A1 transporter
    Stein Roosbeek
    Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, B 9000 Ghent, Belgium
    J Biol Chem 279:37779-88. 2004
    ..To study the possible regulation of the ABCA1 transporter by CK2, we expressed the recombinant cytoplasmic domains of ABCA1, NBD1+R1 and NBD2+R2...
  17. doi Functional implications of the influence of ABCA1 on lipid microenvironment at the plasma membrane: a biophysical study
    Ana Zarubica
    Centre d immunologie de Marseille Luminy, Institut National de la Sante et de la Recherche Medicale, Centre National de la Recherche Scientifique, Universite de la Mediterranee, Parc Scientifique de Luminy Case 906, 13288 Marseille, Cedex 09 France
    FASEB J 23:1775-85. 2009
    The ABCA1 transporter orchestrates cellular lipid homeostasis by promoting the release of cholesterol to plasmatic acceptors. The molecular mechanism is, however, unknown...
  18. ncbi Dominant expression of ATP-binding cassette transporter-1 on basolateral surface of Caco-2 cells stimulated by LXR/RXR ligands
    Tohru Ohama
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 296:625-30. 2002
    ATP-binding cassette transporter-1 (ABCA1) is a cause of Tangier disease, which is a familial deficiency of plasma high density lipoproteins (HDL)...
  19. ncbi The association of the R219K polymorphism in the ATP-binding cassette transporter 1 ( ABCA1) gene with coronary heart disease and hyperlipidaemia
    David Evans
    Klinik und Poliklinik für Innere Medizin, Medizinische Klinik I, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    J Mol Med (Berl) 81:264-70. 2003
    The R219K polymorphism in the ATP-binding cassette transporter 1 gene ( ABCA1) has been associated with reduced severity of atherosclerosis, fewer coronary events, decreased triglycerides and a trend to increased HDL in men with coronary ..
  20. ncbi Expression, regulation, and activity of ABCA1 in human cell lines
    Maxime Denis
    Cardiovascular Genetics Laboratory, McGill University Health Center, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    Mol Genet Metab 78:265-74. 2003
    Mutations in the ATP-binding cassette transporter A1 (ABCA1) gene cause familial high-density lipoprotein deficiency and Tangier disease...
  21. ncbi A common Ile 823 Met variant of ATP-binding cassette transporter A1 gene (ABCA1) alters high density lipoprotein cholesterol level in Japanese population
    Tomohiro Harada
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Atherosclerosis 169:105-12. 2003
    Recently, variants in ATP-binding cassette transporter A1 (ABCA1) were demonstrated to be associated with increased level of high density lipoprotein cholesterol (HDL-C) and decreased risk of coronary artery disease (CAD) in Caucasians...
  22. ncbi The type III inositol 1,4,5-trisphosphate receptor preferentially transmits apoptotic Ca2+ signals into mitochondria
    Carolina C P Mendes
    Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, MG, 31270 901, Brazil
    J Biol Chem 280:40892-900. 2005
    ..These findings provide evidence that the type III isoform of the InsP(3)R plays a special role in induction of apoptosis by preferentially transmitting Ca(2+) signals into mitochondria...
  23. ncbi Common coding polymorphisms in the ABCA1 gene and risk of early-onset coronary heart disease in northern Germany
    Almut Nebel
    Atherosclerosis 193:458-60. 2007
  24. ncbi ATP-binding cassette transporter A1 gene I823M polymorphism affects plasma high-density lipoprotein cholesterol level and modifies the effect of low high-density lipoprotein cholesterol on the risk of coronary artery disease
    Chia Ti Tsai
    Division of Cardiology, Department of Internal Medicine, National Taiwan University, Taipei, Taiwan
    Cardiology 107:321-8. 2007
    The I823M polymorphism of the ATP-binding cassette transporter A1 (ABCA1) gene has been reported to affect plasma high-density lipoprotein cholesterol (HDL-C) level...
  25. pmc The macrophage cholesterol exporter ABCA1 functions as an anti-inflammatory receptor
    Chongren Tang
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 284:32336-43. 2009
    ATP-binding cassette transporter A1 (ABCA1) is a cell membrane protein that exports excess cholesterol from cells to apolipoprotein (apo) A-I, the major protein in high density lipoproteins...
  26. doi The polymorphism of the ATP-binding cassette transporter 1 gene modulates Alzheimer disease risk in Chinese Han ethnic population
    Yi Min Sun
    Department of Neurology and Institute of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai, China
    Am J Geriatr Psychiatry 20:603-11. 2012
    ..The adenosine triphosphate (ATP)-binding cassette transporter 1 (ABCA1) gene resides within proximity of linkage peaks on chromosome 9q influence AD and plays a key role in cellular ..
  27. doi Homocysteine-mediated cholesterol efflux via ABCA1 and ACAT1 DNA methylation in THP-1 monocyte-derived foam cells
    Yu Liang
    Department of Laboratory Medicine, Ningxia Medical University, Yinchuan 750004, China
    Acta Biochim Biophys Sin (Shanghai) 45:220-8. 2013
    ..ATP-binding cassette transporter A1 (ABCA1), which mediates the efflux of cellular cholesterol and phospholipids, is the rate-limiting step in lipid ..
  28. ncbi TGF-beta1 up-regulates expression of ABCA1, ABCG1 and SR-BI through liver X receptor alpha signaling pathway in THP-1 macrophage-derived foam cells
    Yan wei Hu
    Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Life Science Research Center, University of South China, Hengyang, Hunan, China
    J Atheroscler Thromb 17:493-502. 2010
    ..can promote cholesterol efflux from macrophage foam cells via the ATP-binding cassette transporter A1 (ABCA1), ABCG1, and scavenger receptor class B type I (SR-BI)...
  29. ncbi A splice form of polycystin-2, lacking exon 7, does not interact with polycystin-1
    Karl Hackmann
    Institut fur Humangenetik, Universitatsklinikum Munster, Germany
    Hum Mol Genet 14:3249-62. 2005
    ..The predominant expression in brain indicates a function in this organ. The inability to interact with polycystin-1 expands further the PKD1-independent functions of polycystin-2 forms...
  30. ncbi Decreased frequencies of ABCA1 polymorphisms R219K and V771M in Hungarian patients with cerebrovascular and cardiovascular diseases
    Hajnalka Andrikovics
    Department of Molecular Genetics, National Medical Center, Budapest, Hungary
    Cerebrovasc Dis 21:254-9. 2006
    Genetic polymorphisms in ABC transporter A1 (ABCA1) may alter the regulation of plasma high-density lipoprotein (HDL), promoting or protecting from vascular diseases.
  31. ncbi [Correlation of cholesterol 24-hydroxylase and ATP-binding cassette transporter A1 polymorphisms with Alzheimer's disease]
    Fen Wang
    Department of Neurology, Xuanwu Hospital of Capital University of Medical Sciences, Beijing 100053, China
    Zhonghua Yi Xue Za Zhi 87:614-8. 2007
    ..SNPs) A-->G in the intron 2 of cholesterol 24-hydroxylase (CYP46) gene and G-->A (R219K) in the exon 6 of ATP-binding cassette transporter A1 (ABCA1) gene with sporadic Alzheimer's disease (SAD) in the Han Chinese population.
  32. ncbi Human aldehyde oxidase 1 interacts with ATP-binding cassette transporter-1 and modulates its activity in hepatocytes
    A Sigruener
    Institute of Clinical Chemistry and Laboratory Medicine, Regensburg University Medical Center, Regensburg, Germany
    Horm Metab Res 39:781-9. 2007
    AOX1, a member of the cytosolic molybdenum hydroxylase family, has been identified by us earlier as an ABCA1-interacting protein...
  33. ncbi Impaired insulin secretion in four Tangier disease patients with ABCA1 mutations
    Masahiro Koseki
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Atheroscler Thromb 16:292-6. 2009
    ..Recently, it has been reported that ABCA1 is expressed in pancreatic beta cells and mice with specific inactivation of ABCA1 in beta cells showed markedly ..
  34. ncbi Transition from dimers to higher oligomeric forms occurs during the ATPase cycle of the ABCA1 transporter
    Doriane Trompier
    Centre d immunologie de Marseille Luminy, INSERM, CNRS, UniversitédelaMéditerranée, Parc Scientifique de Luminy, 13288 Marseille Cedex 09, France
    J Biol Chem 281:20283-90. 2006
    ..energy transfer and native PAGE analytical techniques were employed to assess the quaternary structure of ABCA1, an ATP binding cassette transporter playing a crucial role in cellular lipid handling...
  35. pmc ABCA1, ABCG1 and SR-BI: hormonal regulation in primary rat hepatocytes and human cell lines
    Marita Sporstøl
    Programme for Cell Biology, Department of Molecular Biosciences, University of Oslo, Norway
    BMC Mol Biol 8:5. 2007
    Scavenger receptor type B class I (SR-BI), ABC transporter A1 (ABCA1) -and G1 (ABCG1) all play important roles in the reverse cholesterol transport...
  36. doi Hyperglycemia suppresses ABCA1 expression in vascular smooth muscle cells
    X Yu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Ikenobe Miki cho, Kita gun, Kagawa, Japan
    Horm Metab Res 42:241-6. 2010
    Hyperglycemia is a major risk factor for atherosclerotic disease. The ATP-binding cassette transporter A1 (ABCA1) functions as a pivotal regulator of lipid efflux from cells to apolipoproteins and is thus involved in lowering the risk of ..
  37. doi Association of loss-of-function mutations in the ABCA1 gene with high-density lipoprotein cholesterol levels and risk of ischemic heart disease
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry, Rigshospitalet, Herlev Hospital
    JAMA 299:2524-32. 2008
    ..Low levels of high-density lipoprotein (HDL) cholesterol are inversely related to cardiovascular risk. Whether this is a causal effect is unclear...
  38. ncbi Apolipoprotein A-I activates protein kinase C alpha signaling to phosphorylate and stabilize ATP binding cassette transporter A1 for the high density lipoprotein assembly
    Yoshio Yamauchi
    Department of Biochemistry, Cell Biology, and Metabolism, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    J Biol Chem 278:47890-7. 2003
    ATP-binding cassette transporter A1 (ABCA1) plays an essential role in the helical apolipoprotein-mediated assembly of high density lipoprotein, and the apolipoporteins stabilize ABCA1 against calpain-mediated degradation during the ..
  39. pmc Anticancer activity of the cholesterol exporter ABCA1 gene
    Bradley Smith
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cell Rep 2:580-90. 2012
    The ABCA1 protein mediates the transfer of cellular cholesterol across the plasma membrane to apolipoprotein A-I...
  40. ncbi Association of the ATP-binding cassette transporter A1 R230C variant with early-onset type 2 diabetes in a Mexican population
    M Teresa Villarreal-Molina
    Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga 15 Colonia Sección 16, Tlalpan 14000, Mexico D F
    Diabetes 57:509-13. 2008
    The ATP-binding cassette transporter A1 (ABCA1) R230C variant is associated with low HDL cholesterol levels, obesity, and the metabolic syndrome in Mexican-Mestizos...
  41. ncbi Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1
    Aya Kobayashi
    Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Kyoto University Graduate School of Agriculture, Kyoto 606 8502, Japan
    J Lipid Res 47:1791-802. 2006
    ..Mass and TLC analyses revealed that ABCG1 and ABCA1 secrete several species of sphingomyelin (SM) and phosphatidylcholine (PC), and SMs were preferentially secreted ..
  42. doi Carbohydrate intake modulates the effect of the ABCA1-R230C variant on HDL cholesterol concentrations in premenopausal women
    Sandra Romero-Hidalgo
    Computational Genomics Department, Instituto Nacional de Medicina Genomica, Mexico City, Mexico
    J Nutr 142:278-83. 2012
    The R230C variant of the ATP-binding cassette transporter A1 (ABCA1) gene has been consistently associated with decreased HDL-cholesterol (HDL-C) concentrations in several studies in the Mexican mestizo population...
  43. ncbi Interleukin-18 and interleukin-12 together downregulate ATP-binding cassette transporter A1 expression through the interleukin-18R/nuclear factor-κB signaling pathway in THP-1 macrophage-derived foam cells
    Xiao hua Yu
    Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Life Science Research Center, University of South China, Hengyang, Hunan, China
    Circ J 76:1780-91. 2012
    ..synergize for the production of interferon (IFN)-γ, which can downregulate ATP-binding cassette transporter A1 (ABCA1) expression. The aim of the present study was to investigate the effect of IL-18 and/or IL-12 on ABCA1 expression.
  44. ncbi Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
    A Brooks-Wilson
    Xenon Bioresearch Inc, NRC Innovation Centre, Vancouver, British Columbia, Canada
    Nat Genet 22:336-45. 1999
    ..This indicates that the protein encoded by ABC1 is a key gatekeeper influencing intracellular cholesterol transport, hence we have named it cholesterol efflux regulatory protein (CERP).
  45. ncbi Effects of apolipoprotein A-I on ATP-binding cassette transporter A1-mediated efflux of macrophage phospholipid and cholesterol: formation of nascent high density lipoprotein particles
    Lijuan Liu
    Gastrointestinal Nutrition Division, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
    J Biol Chem 278:42976-84. 2003
    ..of formation of high density lipoprotein (HDL) particles by the action of ATP-binding cassette transporter A1 (ABCA1) is not defined completely...
  46. ncbi Multiple rare alleles contribute to low plasma levels of HDL cholesterol
    Jonathan C Cohen
    Donald W Reynolds Cardiovascular Clinical Research Center and McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA
    Science 305:869-72. 2004
    ..We sequenced three candidate genes (ABCA1, APOA1, and LCAT) that cause Mendelian forms of low HDL-C levels in individuals from a population-based study...
  47. ncbi The C-terminal lipid-binding domain of apolipoprotein E is a highly efficient mediator of ABCA1-dependent cholesterol efflux that promotes the assembly of high-density lipoproteins
    Charulatha Vedhachalam
    GI Nutrition Division, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
    Biochemistry 46:2583-93. 2007
    ..of human apoE that mediate cellular cholesterol efflux and HDL assembly via ATP-binding cassette transporter A1 (ABCA1)...
  48. ncbi Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): evidence for sterol-dependent regulation in macrophages
    T Langmann
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, 93042, Germany
    Biochem Biophys Res Commun 257:29-33. 1999
    ..Our data, demonstrating sterol-dependent regulation of hABC1 in human monocytes/macrophages, suggest a novel role for this transporter molecule in membrane lipid transport...
  49. ncbi The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease
    M Bodzioch
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Germany
    Nat Genet 22:347-51. 1999
    ..The TD locus has been mapped to chromosome 9q31. Here we present evidence that TD is caused by mutations in ABC1, encoding a member of the ATP-binding cassette (ABC) transporter family, located on chromosome 9q22-31...
  50. pmc A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I
    Nan Wang
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Clin Invest 111:99-107. 2003
    Cholesterol-loaded macrophage foam cells are a central component of atherosclerotic lesions. ABCA1, the defective molecule in Tangier disease, mediates the efflux of phospholipids and cholesterol from cells to apoA-I, reversing foam cell ..
  51. ncbi ABCA1 expression in carotid atherosclerotic plaques
    C Albrecht
    MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital, Du Cane Road, London, UK
    Stroke 35:2801-6. 2004
    The ATP-binding cassette transporter A1 (ABCA1) facilitates cholesterol efflux from cells, a key process in reverse cholesterol transport...
  52. ncbi Functional polymorphism in ABCA1 influences age of symptom onset in coronary artery disease patients
    Theodosios Kyriakou
    Human Genetics Division, School of Medicine, University of Southampton, UK
    Hum Mol Genet 16:1412-22. 2007
    ATP-binding-cassette-transporter-A1 (ABCA1) plays a pivotal role in intracellular cholesterol removal, exerting a protective effect against atherosclerosis...
  53. pmc High glucose, unsaturated and saturated fatty acids differentially regulate expression of ATP-binding cassette transporters ABCA1 and ABCG1 in human macrophages
    Richard Mauerer
    Synlab Medical Care Service, Medical Care Centre Weiden, Zur Kesselschmiede 4, 92637 Weiden, Germany
    Exp Mol Med 41:126-32. 2009
    The ATP-binding cassette transporters ABCA1 and ABCG1 are highly expressed in macrophage-derived foam cells and promote reverse cholesterol efflux via biogenesis of high-density lipoproteins...
  54. ncbi Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1
    S Rust
    Institut für Arterioskleroseforschung an der Westfälischen Wilhelms Universität Münster, Germany
    Nat Genet 22:352-5. 1999
    ..and D9S1866 on chromosome 9q31, in which we found the gene encoding human ATP cassette-binding transporter 1 (ABC1)...
  55. pmc Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells
    Salim Maa Bared
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, 93040 Regensburg, Germany
    Mol Biol Cell 15:5399-407. 2004
    The ATP-binding cassette transporter A1 (ABCA1) facilitates the cellular release of cholesterol and choline-phospholipids to apolipoprotein A-I (apoA-I) and several studies indicate that vesicular transport is associated with ABCA1 ..
  56. ncbi Common polymorphisms of ATP binding cassette transporter A1, including a functional promoter polymorphism, associated with plasma high density lipoprotein cholesterol levels in Turks
    Ugur Hodoglugil
    Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, CA 94158, USA
    Atherosclerosis 183:199-212. 2005
    ..of atherosclerosis is generally attributed to its role in reverse cholesterol transport, and the ATP binding cassette transporter A1 (ABCA1) is a key element of this process...
  57. ncbi Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice
    Radosveta Koldamova
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 280:43224-35. 2005
    b>ABCA1 (ATP-binding cassette transporter A1) is a major regulator of cholesterol efflux and high density lipoprotein (HDL) metabolism...
  58. ncbi Associations between two common polymorphisms in the ABCA1 gene and subclinical atherosclerosis: Multi-Ethnic Study of Atherosclerosis (MESA)
    Jeana L Benton
    The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Atherosclerosis 193:352-60. 2007
    b>ABCA1 controls the first step in reverse cholesterol transport...
  59. ncbi Correction of apolipoprotein A-I-mediated lipid efflux and high density lipoprotein particle formation in human Niemann-Pick type C disease fibroblasts
    Emmanuel Boadu
    Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Biol Chem 281:37081-90. 2006
    ..disease results in the first known instance of impaired regulation of the ATP-binding cassette transporter A1 (ABCA1), a lipid transporter mediating the rate-limiting step in high density lipoprotein (HDL) formation, as a cause of ..
  60. ncbi ABCA1 expression in humans is associated with physical activity and alcohol consumption
    Anh Hoang
    Baker Heart Research Institute, Commercial Road, PO Box 6492, St Kilda Road Central, Melbourne, VIC 8008, Australia
    Atherosclerosis 197:197-203. 2008
    Genetic variation in ABCA1 significantly affects HDL levels and atherosclerotic risk. The aim of this study was to examine lifestyle factors influencing ABCA1 expression in human leukocytes and skeletal muscle...
  61. doi Eicosapentaenoic acid reduces ABCA1 serine phosphorylation and impairs ABCA1-dependent cholesterol efflux through cyclic AMP/protein kinase A signaling pathway in THP-1 macrophage-derived foam cells
    Yan wei Hu
    Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Life Science Research Center, University of South China, Hengyang, Hunan 421001 China
    Atherosclerosis 204:e35-43. 2009
    b>ABCA1 is a key mediator of cholesterol efflux to apoA-I in cholesterol loaded macrophages, a first step of RCT in vivo. Unsaturated fatty acids can inhibit cholesterol efflux from macrophages by increasing degradation of ABCA1...
  62. pmc Carriers of loss-of-function mutations in ABCA1 display pancreatic beta-cell dysfunction
    Menno Vergeer
    Department of Vascular Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands
    Diabetes Care 33:869-74. 2010
    ..beta-Cell deficiency for the ATP binding cassette transporter A1 (ABCA1), which mediates the efflux of cellular cholesterol, leads to altered intracellular ..
  63. ncbi Common and rare ABCA1 variants affecting plasma HDL cholesterol
    J Wang
    John P Robarts Research Institute, London, Ontario, Canada
    Arterioscler Thromb Vasc Biol 20:1983-9. 2000
    Mutations in ABCA1, a member of the ATP-binding cassette family, have been shown to underlie Tangier disease (TD) and familial hypoalphalipoproteinemia (FHA), which are genetic disorders that are characterized by depressed concentrations ..
  64. ncbi ABCA1(Alabama): a novel variant associated with HDL deficiency and premature coronary artery disease
    Seung Ho Hong
    Section of Cardiology, Department of Medicine, University of Maryland and Veterans Administration Medical Center, 22 S Greene St, S3B06, Baltimore, MD 21201, USA
    Atherosclerosis 164:245-50. 2002
    The ATP-binding cassette transporter, ABCA1, is a member of the ABC superfamily of proteins involved in the active transport of substrates across cellular membranes...
  65. ncbi ATP-binding cassette transporter 1 participates in LDL oxidation by artery wall cells
    Srinivasa T Reddy
    Atherosclerosis Research Unit, Division of Cardiology, Department of Medicine, University of California, Los Angeles 90095, USA
    Arterioscler Thromb Vasc Biol 22:1877-83. 2002
    ..ATP-binding cassette transporter 1 (ABCA1) is known to facilitate the release of cellular phospholipids and cholesterol from the plasma membrane to apoA-I ..
  66. ncbi Apolipoprotein A-1 interaction with plasma membrane lipid rafts controls cholesterol export from macrophages
    Katharina Gaus
    Macrophage Biology Group, Centre for Vascular Research, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia
    FASEB J 18:574-6. 2004
    ..We propose that cholesterol exported to apoA-1 from this major slow efflux pool derives from nonraft regions of the plasma membrane but that the interaction of apoA-1 with lipid rafts is necessary to stimulate this efflux...
  67. ncbi In-depth haplotype analysis of ABCA1 gene polymorphisms in relation to plasma ApoA1 levels and myocardial infarction
    David Alexandre Tregouet
    INSERM U525, Faculté de Médecine de la Pitié Salpétrière, Paris, France
    Arterioscler Thromb Vasc Biol 24:775-81. 2004
    By regulating the cellular cholesterol efflux from peripheral cells to high-density lipoprotein, the ABCA1 protein is suspected to play a key role in lipid homeostasis and atherosclerosis...
  68. ncbi Headgroup-specific exposure of phospholipids in ABCA1-expressing cells
    Nele Alder-Baerens
    Humboldt University of Berlin, Institute of Biology, Center of Biophysics and Bioinformatics, Invalidenstrasse 42, 10115 Berlin, Germany
    J Biol Chem 280:26321-9. 2005
    b>ABCA1 has been established to be required for the efflux of cholesterol and phospholipids to apolipoproteins such as apoA-I...
  69. pmc Cooperation between engulfment receptors: the case of ABCA1 and MEGF10
    Yannick Hamon
    Centre d immunologie de Marseille Luminy, Institut National de la Sante et de la Recherche Medicale, Universite de la Mediterranee, Marseille, France
    PLoS ONE 1:e120. 2006
    ..of forced expression by transfection, MEGF10 function can be modulated by the ATP binding cassette transporter ABCA1, ortholog to CED-7...
  70. ncbi A novel intronic polymorphism of ABCA1 gene reveals risk for sporadic Alzheimer's disease in Chinese
    Leung Wing Chu
    Department of Medicine, The University of Hong Kong, Hong Kong
    Am J Med Genet B Neuropsychiatr Genet 144:1007-13. 2007
    Recent genetic studies have shown that variants of the ATP-binding cassette transporter A1, ABCA1, may be implicated in the pathogenesis of Alzheimer's disease (AD)...
  71. pmc Human ATP-binding cassette transporter 1 (ABC1): genomic organization and identification of the genetic defect in the original Tangier disease kindred
    A T Remaley
    National Institutes of Health, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:12685-90. 1999
    ..b>ABC1, a member of the ATP-binding cassette family, recently has been identified as the defective gene in Tangier disease...
  72. ncbi Novel mutations in the gene encoding ATP-binding cassette 1 in four tangier disease kindreds
    M E Brousseau
    Lipid Metabolism Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University and Department of Medicine, New England Medical Center, Boston, MA 02111, USA
    J Lipid Res 41:433-41. 2000
    ..These results establish a causal role for mutations in hABC-1 in TD and indicate that this transporter has a critical function in the regulation of intracellular lipid trafficking that dramatically affects plasma HDL cholesterol levels...
  73. pmc Complete genomic sequence of the human ABCA1 gene: analysis of the human and mouse ATP-binding cassette A promoter
    S Santamarina-Fojo
    National Heart, Lung, and Blood Institute, and Clinical Center, Clinical Pathology Department, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:7987-92. 2000
    The ABCA1 gene, a member of the ATP-binding cassette A (ABCA1) transporter superfamily, encodes a membrane protein that facilitates the cellular efflux of cholesterol and phospholipids...
  74. pmc Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes
    S M Clee
    Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada
    J Clin Invest 106:1263-70. 2000
    We and others have recently identified mutations in the ABCA1 gene as the underlying cause of Tangier disease (TD) and of a dominantly inherited form of familial hypoalphalipoproteinemia (FHA) associated with reduced cholesterol efflux...
  75. ncbi Common variants in the gene encoding ATP-binding cassette transporter 1 in men with low HDL cholesterol levels and coronary heart disease
    M E Brousseau
    The Lipid Metabolism Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts, Boston, MA, USA
    Atherosclerosis 154:607-11. 2001
    ..Recently, our laboratory and others demonstrated that mutations in the ATP-binding cassette transporter 1 (ABCA1) gene are responsible for Tangier disease, a rare genetic disorder characterized by severely diminished plasma HDL-..
  76. ncbi Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: an observational study
    Marjel J van Dam
    Departments of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Lancet 359:37-42. 2002
    ..Cholesterol efflux is mediated by the ATP-binding cassette A1 transporter (ABCA1), the rate-limiting step in the production of HDL...
  77. ncbi Novel ABCA1 compound variant associated with HDL cholesterol deficiency
    Seung Ho Hong
    Department of Medicine, University of Maryland and Veterans Administration Medical Center, 22 S Greene St, S3B06 Baltimore 21201, USA
    Biochim Biophys Acta 1587:60-4. 2002
    The recent discovery of an ATP-binding cassette transporter, ABCA1, as an important regulator of high density lipoprotein (HDL) metabolism and reverse cholesterol transport has facilitated the identification of novel variants associated ..
  78. ncbi ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, August Forel Street 1, 8008, Zurich, Switzerland
    Neurobiol Aging 24:421-6. 2003
    ..High cellular cholesterol load promotes Abeta formation. The ATP-binding cassette transporter A1 (ABCA1) mediates cholesterol efflux from cells...
  79. ncbi ABCA1 gene polymorphisms and their associations with coronary artery disease and plasma lipids in males from three ethnic populations in Singapore
    Jenny Hui Hui Tan
    Department of Pediatrics, National University of Singapore, 5 Lower Kent Ridge Road, 119074, Singapore
    Hum Genet 113:106-17. 2003
    Mutations in the ATP-binding cassette transporter ABCA1 underlie Tangier disease and familial hypoalphaliproteinemia (FHA), disorders that are characterised by reduced high-density lipoprotein-cholesterol (HDL-C) concentration and ..
  80. ncbi Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpression of human ABCA1
    Cheryl L Wellington
    Centre for Molecular Medicine and Therapeutics, British Columbia Children s and Women s Hospital, University of British Columbia, Vancouver, BC, Canada
    J Lipid Res 44:1470-80. 2003
    b>ATP binding cassette transporter A1 (ABCA1) is a widely expressed lipid transporter essential for the generation of HDL. ABCA1 is particularly abundant in the liver, suggesting that the liver may play a major role in HDL homeostasis...
  81. ncbi Efflux and atherosclerosis: the clinical and biochemical impact of variations in the ABCA1 gene
    Roshni R Singaraja
    Centre for Molecular Medicine and Therapeutics, University of British Columbia, and Children s and Women s Hospital, Vancouver, BC, Canada
    Arterioscler Thromb Vasc Biol 23:1322-32. 2003
    Approximately 50 mutations and many single nucleotide polymorphisms have been described in the ABCA1 gene, with mutations leading to Tangier disease and familial hypoalphalipoproteinemia...
  82. ncbi Novel polypyrimidine variation (IVS46: del T -39...-46) in ABCA1 causes exon skipping and contributes to HDL cholesterol deficiency in a family with premature coronary disease
    Seung Ho Hong
    Department of Medicine, University of Maryland and Veterans Administration Medical Center, Baltimore, MD, USA
    Circ Res 93:1006-12. 2003
    Recent studies have implicated mutations in the ATP-binding cassette transporter A1, ABCA1, as a cause of Tangier disease (TD) and familial hypoalphalipoproteinemia (FHA)...
  83. ncbi Janus kinase 2 modulates the apolipoprotein interactions with ABCA1 required for removing cellular cholesterol
    Chongren Tang
    Department of Medicine, University of Washington, Seattle, Washington 98195 6426, USA
    J Biol Chem 279:7622-8. 2004
    ATP-binding cassette transporter A1 (ABCA1) mediates transport of cellular cholesterol and phospholipids to high density lipoprotein (HDL) apolipoproteins, such as apoA-I...
  84. ncbi Leukocyte ABCA1 gene expression is associated with fasting glucose concentration in normoglycemic men
    C Albrecht
    Medical Research Council Clinical Sciences Center, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK
    Metabolism 53:17-21. 2004
    Adenosine triphosphate (ATP)-binding cassette transporter A1 (ABCA1) mediates the efflux of cholesterol to apolipoprotein A1, a process necessary for high-density lipoprotein (HDL) formation and reverse cholesterol transport...
  85. ncbi The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease
    Edward B Neufeld
    Molecular Disease Branch, NHLBI, NHLBI Light Microscopy Core Facility, and Laboratory for Cellular Biology and Biochemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:15571-8. 2004
    We have previously established that the ABCA1 transporter, which plays a critical role in the lipidation of extracellular apolipoprotein acceptors, traffics between late endocytic vesicles and the cell surface (Neufeld, E. B., Remaley, A...
  86. ncbi Genetic polymorphisms affecting the phenotypic expression of familial hypercholesterolemia
    Stefano Bertolini
    Department of Internal Medicine, University of Genoa, Viale Benedetto XV 6, I 16132 Genoa, Italy
    Atherosclerosis 174:57-65. 2004
    ..Apo B (-516C/T), Apo A-V (-1131T/C), HL (-514C/T and -250G/A), FABP-2 (A54T), LPL (D9N, N291S, S447X) and ABCA1 (R219K) polymorphisms in 221 unrelated FH index cases and 349 FH relatives with defined LDL-R gene mutations...
  87. ncbi Screening for functional sequence variations and mutations in ABCA1
    Mario C O Probst
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, Regensburg DE 93053, Germany
    Atherosclerosis 175:269-79. 2004
    Mutations in the ATP-binding cassette 1 transporter gene (ABCA1) are responsible for the genetic HDL-deficiency syndromes, which are characterized by severely diminished plasma HDL-C levels and a predisposition to cardiovascular disease ..
  88. ncbi A PEST deletion mutant of ABCA1 shows impaired internalization and defective cholesterol efflux from late endosomes
    Wengen Chen
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    J Biol Chem 280:29277-81. 2005
    ATP-binding cassette transporter A1 (ABCA1) promotes the efflux of cellular cholesterol and phospholipids to apoA-I...
  89. ncbi R1615P: a novel mutation in ABCA1 associated with low levels of HDL and type II diabetes mellitus
    Danish Saleheen
    Int J Cardiol 110:259-60. 2006
  90. ncbi Candidate gene susceptibility variants predict intermediate end points but not angiographic coronary artery disease
    Bryant M Whiting
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    Am Heart J 150:243-50. 2005
    ..Moderate-sized studies have suggested that variants of candidate genes can influence laboratory markers of coronary artery disease (CAD), but whether they predict parallel changes in clinical CAD risk is unknown...
  91. ncbi Specific mutations in ABCA1 have discrete effects on ABCA1 function and lipid phenotypes both in vivo and in vitro
    Roshni R Singaraja
    Center for Molecular Medicine and Therapeutics, University of British Columbia and Child and Family Research Institute, Vancouver, British Columbia, Canada
    Circ Res 99:389-97. 2006
    Mutations in ATP-binding cassette transporter A1 (ABCA1) cause Tangier disease and familial hypoalphalipoproteinemia, resulting in low to absent plasma high-density lipoprotein cholesterol levels...
  92. ncbi The ATP-binding cassette transporter A1 R230C variant affects HDL cholesterol levels and BMI in the Mexican population: association with obesity and obesity-related comorbidities
    M Teresa Villarreal-Molina
    Unit of Molecular Biology and Genomic Medicine, Salvador Zubiran National Institute of Medical Sciences and Nutrition INCMNSZ, National Autonomous University of Mexico, Mexico City, Mexico
    Diabetes 56:1881-7. 2007
    Although ATP-binding cassette transporter A1 (ABCA1) is well known for its role in cholesterol efflux and HDL formation, it is expressed in various tissues, where it may have different functions...
  93. ncbi Genotypic variation in ATP-binding cassette transporter-1 (ABCA1) as contributors to the high and low high-density lipoprotein-cholesterol (HDL-C) phenotype
    Myrna Mantaring
    Department of Medicine, University of Maryland Medical Center and VA Maryland Health Care System, Baltimore, MD, USA
    Transl Res 149:205-10. 2007
    The ATP-binding cassette transporter-1 (ABCA1) mediates cholesterol efflux and genotypic variation in ABCA1 and may impact reverse cholesterol transport and influence cardiovascular disease (CVD) risk...
  94. ncbi R219K polymorphism of ATP binding cassette transporter A1 related with low HDL in overweight/obese Thai males
    Anong Kitjaroentham
    Department of Tropical Nutrition and Food Science, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Arch Med Res 38:834-8. 2007
    b>ATP binding cassette transporter A1 (ABCA1) plays a role in the initial stage of removing cholesterol from the body via cholesterol efflux...
  95. pmc Reduced expression of ATP-binding cassette transporter G1 increases cholesterol accumulation in macrophages of patients with type 2 diabetes mellitus
    Jeremy P Mauldin
    Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    Circulation 117:2785-92. 2008
    ..The ATP-binding cassette (ABC) transporters ABCA1 and ABCG1 regulate macrophage cholesterol efflux and hence play a vital role in macrophage foam cell formation...
  96. pmc Direct interaction of nuclear liver X receptor-beta with ABCA1 modulates cholesterol efflux
    Masako Hozoji
    Laboratory of Cellular Biochemistry, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    J Biol Chem 283:30057-63. 2008
    ..Therefore, the ABCA1 gene, the product of which mediates secretion of cholesterol, is highly regulated at both the transcriptional and ..
  97. doi Associations of genetic variants in ATP-binding cassette A1 and cholesteryl ester transfer protein and differences in lipoprotein subclasses in the multi-ethnic study of atherosclerosis
    Michael Y Tsai
    Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455 0392, USA
    Clin Chem 55:481-8. 2009
    ATP-binding cassette A1 (ABCA1) and cholesteryl ester transfer protein (CETP) play important roles in the reverse cholesterol transport pathway...
  98. doi Genetic variation in the ABCA1 gene, HDL cholesterol, and risk of ischemic heart disease in the general population
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen Ø DK 2100, Denmark
    Atherosclerosis 208:305-16. 2010
    ..This review focuses on whether both rare and common genetic variation in ABCA1 contributes to plasma levels of HDL cholesterol and to risk of IHD in the general population, and further seeks to ..
  99. doi Effect of R219K polymorphism of the ABCA1 gene on the lipid-lowering effect of pravastatin in Chinese patients with coronary heart disease
    Jia Li
    Department of Cardiac Care Unit, The First Affiliated Hospital of Harbin Medical University, Harbin, China
    Clin Exp Pharmacol Physiol 36:567-70. 2009
    ..present study, we investigated the effects of the R219K polymorphism of the ATP-binding cassette transporter A1 (ABCA1) gene on serum lipid levels and the response to statin therapy in Chinese patients with coronary heart disease (..
  100. pmc ABCA1 gene variants regulate postprandial lipid metabolism in healthy men
    Javier Delgado-Lista
    Lipids and Atherosclerosis Unit, Instituto Maimonides de Investigacion Biomedica de Cordoba, Cordoba, Spain
    Arterioscler Thromb Vasc Biol 30:1051-7. 2010
    Genetic variants of ABCA1, an ATP-binding cassette (ABC) transporter, have been linked to altered atherosclerosis progression and fasting lipid concentration, mainly high-density lipoproteins and apolipoprotein A1; however, results from ..
  101. doi Association of R230C ABCA1 gene variant with low HDL-C levels and abnormal HDL subclass distribution in Mexican school-aged children
    Teresa Flores-Dorantes
    Unit of Molecular Biology and Genomic Medicine, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    Clin Chim Acta 411:1214-7. 2010
    The effect of ABCA1 genetic variation on HDL-C levels has been widely documented, although studies in children are scarce...

Research Grants83

  1. Anti-inflammatory, cholesterol export, and cardioprotective functions of ABCA1
    Renee C LeBoeuf; Fiscal Year: 2013
    ..A major cardioprotective factor associated with HDL metabolism is ATP-binding cassette transporter A1 (ABCA1), a cell membrane protein that exports cholesterol and phospholipids from cells to lipid-depleted HDL ..
  2. Membrane biophysics of enterotoxin mediated immunomodulation
    Arnd Pralle; Fiscal Year: 2013
    ..proteins with lipid- and protein-membrane domains, and the membrane cytoskeleton;and by indentifying which membrane bound immune signaling processes are influenced by Enterotoxin binding...
  3. MATTHEW LAWRENCE WILLIAMS; Fiscal Year: 2014
    ..are recognized: Ffh, a protein with GTP hydrolysis (GTPase) activity that binds nascent polypeptides;FtsY, a membrane bound receptor that binds Ffh and helps target nascent peptides to the translocon channel;and a small cytoplasmic ..
  4. Subtype Specific LXR Activity Limits Atherosclerosis
    Ira G Schulman; Fiscal Year: 2013
    ..cholesterol transport (RCT), by increasing expression of the genes encoding the ATP binding cassette transporters ABCA1 and ABCG1 and the apolipoprotein apoE...
  5. Multicolor Cell Membrane Profiling For Development And Disease
    BRIAN DAVID GRAY; Fiscal Year: 2013
    ..lipophilic dyes we propose to develop fixable carbocyanine dyes that can be bonded to lysine groups in membrane bound proteins thereby retaining the dyes in the membranes even after the lipid bilayers has been removed with ..
  6. A Novel Approach to Identify HIV Suppression Factor from CD8 Cells
    Phalguni Gupta; Fiscal Year: 2010
    ..The objective of the proposed study is to use a combined biochemical and proteomic approach to conclusively identify the HIV-1 suppressive factor from the exosome-derived soluble factor. ..
  7. ALAN RICHARD TALL; Fiscal Year: 2016
    ..macrophage foam cells to HDL or apoA-1, a process mediated in part by the ATP binding cassette transporters ABCA1 and ABCG1...
  8. Mei Hong; Fiscal Year: 2016
    ....
  9. Anjali Ganda; Fiscal Year: 2016
    ..Two ATP-binding cassette transporters, ABCA1 and ABCG1, play key roles in promoting HDL-mediated cholesterol efflux. Murine studies in Dr...
  10. Microfluidic Processors for Directed Evolution and Synthetic Biology
    Brian M Paegel; Fiscal Year: 2011
    ..abstract_text> ..
  11. Frederick R Maxfield; Fiscal Year: 2014
    ..Although proteins such as ABCA1 and ABCG4 are essential for export of cholesterol to HDLs, the precise role of these proteins remains unclear...
  12. Macrophage, ABCA1, Inflammation, and Atherosclerosis
    John S Parks; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): ATP binding cassette transporter A1 (ABCA1) is a membrane protein that is required to remove excess lipid from macrophages...
  13. Imaging supported lipid bilayers and actual cell membrane fragments by NanoSIMS
    MONICA LOZANO; Fiscal Year: 2011
    ..In these studies, secondary ion mass spectrometry (nanoSIMS) imaging will be used to obtain quantitative compositional information with nanometer scale resolution of model and actual cell membranes. ..
  14. Atherogenic Effects of Oxidized High Density Lipoproteins
    Jay W Heinecke; Fiscal Year: 2010
    The interaction of the HDL protein apoA-l with the cell membrane transporter ABCA1 removes excess cellular cholesterol and protects against atherogenesis...
  15. Nanopore Biosensor for Kinetics of Reparative Antibodies on Plasma Membranes
    Sang Hyun Oh; Fiscal Year: 2013
    ....
  16. Quantitative Analysis of RET Receptor Activation and Signaling
    Adrian Whitty; Fiscal Year: 2013
    ..abstract_text> ..
  17. Makio Iwashima; Fiscal Year: 2014
    ....
  18. JOHN DAVID CASTLE; Fiscal Year: 2015
    ..proposal have shown that deficiencies in pancreatic [unreadable] cells in the ATP-binding cassette transporters ABCA1 and ABCG1, which have been implicated to promote cellular export of cholesterol to plasma lipoproteins by most ..
  19. ALAN RICHARD TALL; Fiscal Year: 2014
    ..to promote efflux of cholesterol and toxic oxysterols from cells via the ATP binding cassette transporters, ABCA1 and ABCG1...
  20. ABCs of Cholesterol Regulation in the Insulin Secretory Pathway
    JOHN DAVID CASTLE; Fiscal Year: 2011
    ..of this proposal have shown that deficiencies in pancreatic beta cells in the ATP-binding cassette transporters ABCA1 and ABCG1, which have been implicated to promote cellular export of cholesterol to plasma lipoproteins by most ..
  21. Cellular Cholesterol Movement and Homeostasis
    Yvonne Lange; Fiscal Year: 2012
    ..of plasma membrane cholesterol to circulating high density lipoproteins by the scavenger receptor SR-BI and the ABCA1 transporter. A novel hypothesis for the mysterious molecular mechanism of general anesthesia is also proposed...
  22. Neuropeptide regulation of neurohypophyseal function
    Francis W Flynn; Fiscal Year: 2012
    ..The nuclear translocation of the neurokinin receptor to the nucleus is novel and has implications for a large number of pathologies, such as epilepsy, that are linked to this receptor system in the brain. ..
  23. Thomas J Meade; Fiscal Year: 2015
    ..designed and synthesized with varying polarities, charges, and water solubilities that will selectively probe membrane bound receptors or receptors located inside the cells and tumors. AIM 2...
  24. Yehia Daaka; Fiscal Year: 2014
    ..We identified NOS/NO and dynamin2 as regulators of E. coli invasion into bladder cells. The targeting of eNOS and dynamin2 may provide a window of opportunity to interfere with currently untreatable recurrent UTIs. ..
  25. RICHARD HSINSHIN HO; Fiscal Year: 2016
    ....
  26. Fan Yuan; Fiscal Year: 2016
    ....
  27. White Matter Protection in Acute Ischemic Stroke
    Chia Yi Kuan; Fiscal Year: 2012
    ..By quantitative analysis and outcome comparison among various treatment-groups, these experiments will suggest strategies of WM protection and shed new insights into the mechanisms of WM injury in acute ischemic stroke. ..
  28. ALFONSO MONDRAGON; Fiscal Year: 2014
    ..is accomplished through an adaptor protein, ankyrin, which bridges the interaction between 2-spectrin and the membrane bound anion- exchange transporter band 3...
  29. Membranes in the Initiation of Chromsomal Replication
    Elliott Crooke; Fiscal Year: 2010
    ..Furthermore, advances in understanding of how membrane lipids influence DnaA may help direct future investigations in the emerging field of phospholipid-mediated regulation of enzymaticactivities. ..
  30. Jun Liu; Fiscal Year: 2016
    ....
  31. Lei Zheng; Fiscal Year: 2015
    ..In addition, many proteins, both globular and membrane bound, require specific phospholipids to fulfill their functions...
  32. Sandeep Jain; Fiscal Year: 2016
    ....
  33. Giorgio Cavigiolio; Fiscal Year: 2016
    ..Including ABCA1, which is the primary mechanism underlying the anti-atherogenic function of apoA-I. a...
  34. A novel computational model of B cell signaling and activation
    Craig J Benham; Fiscal Year: 2011
    ..Our computer model will help elucidate the fundamental regulation mechanisms underlying the B cell immune response and could potentially be applied to investigate B cell mediated diseases. ..
  35. Histone deacetylases and atherosclerosis
    Nilamadhab Mishra; Fiscal Year: 2010
    ..marrow derived macrophages to study the effect of different levels of expression of HDAC9 on cholesterol efflux (ABCA1, ABCG1, and SR-B1 mediated), cholesterol esterification, and lipoprotein binding and degradation...
  36. Ann Marie Schmidt; Fiscal Year: 2016
    ..In parallel, mRNA levels for the two key cholesterol transporters, Abca1 and Abcg1, were H2-fold and >250-fold higher in RAGE null BMDMs vs. wild- type BMDMs, respectively...
  37. Macrophage Produced Phospholipid Transfer Protein (PLTP)
    Linda K Curtiss; Fiscal Year: 2012
    ..We will determine if wild-type (WT) or mutant PLTP (which binds ABCA1 but lacks lipid transfer activity) disrupts lipid rafts and/or inhibits TLR2/1 dimerization in vivo and in vitro...
  38. Inflammatory Mechanisms and Treatment Strategies for Atherosclerosis in HIV
    STEVEN KYLE GRINSPOON; Fiscal Year: 2013
    ..HIV-1 Nef protein impairs efflux of cholesterol from macrophages by downregulation of ATP binding cassette transporter A1 (ABCA1), and thus, promotes foam cell formation...
  39. ELEXSYS E500 CW EPR SPECTROMETER
    Jack H Freed; Fiscal Year: 2010
    ..f) We are constructing phase diagrams for multi-component lipid mixtures. Some of the phase boundaries, as well as the thermodynamic tielines, are best determined by use of ESR spectroscopy of spin-labeled lipid probes. ..
  40. Angel Baldán; Fiscal Year: 2016
    ..Our published and preliminary studies show that physiological targets of miR-33 include ABCA1, a transporter critical for HDL lipidation and reverse cholesterol transport, and ATP8B1, a phospholipid flippase ..
  41. PAUL THOMAS HENDERSON; Fiscal Year: 2015
    ....
  42. RYAN EUGENE TEMEL; Fiscal Year: 2016
    ..A major target of miR-33a/b is the ATP binding cassette transporter A1 (ABCA1), a protein essential for cholesterol efflux from foam cells and the formation of HDL...
  43. Macrophage Foam Cells, Cathepsins and Cholesterol Efflux
    ALAN RICHARD TALL; Fiscal Year: 2010
    ..The ATP binding cassette transporter ABCA1 mediates cholesterol efflux from macrophage foam cells to apoA-1...
  44. Eicke Latz; Fiscal Year: 2016
    ..cholesterol crystals in atherosclerotic lesions of LDLR-/- mice and test if these effects of HDL depend on ABCA1 cholesterol efflux transporter;4) Determine the HDL particle proteomic and lipid content from a cohort of normal ..
  45. Human ApoE4 and Foam Cell Formation
    EMMANUEL UGOCHUKWU OKORO; Fiscal Year: 2011
    ..lipoproteins to induce the expression of the cholesterol efflux transporter, ATP-binding cassette transporter A1 (ABCA1), in macrophages...
  46. Liwu Li; Fiscal Year: 2016
    ..In particular, reduced cholesterol export due to decreased ABCA1/ABCG1 expression in macrophages leads to the foam cell formation...
  47. Jay W Heinecke; Fiscal Year: 2016
    ..MPO impairs apoA-I's ability to remove cholesterol from macrophages by the ABCA1 pathway...
  48. Ehrlichiacidal Mechanism in Leukocytes
    Yasuko Rikihisa; Fiscal Year: 2011
    ..abstract_text> ..
  49. Physiological Role of NPC1L1 in Lipid Transport and Metabolism
    David Y Hui; Fiscal Year: 2010
    ..However, whether NPC1L1 is a membrane bound protein serving as a transporter for cholesterol uptake by enterocytes or an intracellular protein responsible ..
  50. Cell Biology of ABCA1
    MASON FREEMAN; Fiscal Year: 2006
    ..in Tangier disease maps to a locus encoding a member of the ABCA family of ATP- binding cassette transporters (ABCA1) and that this transporter is required for normal, apolipoprotein-stimulated cholesterol efflux...
  51. Daniel A Starr; Fiscal Year: 2016
    ....
  52. Conformations and interactions of insect olfactory receptor proteins
    ROBERT D RENTHAL; Fiscal Year: 2010
    ..Also, one component of the insect pheromone receptor is similar to human proteins involved in atherosclerosis, inflammatory response, metabolic syndrome, cardiomyopathies, high frequency hearing loss, and Gaucher's disease. ..
  53. BIOSYNTHESIS OF MEMBRANE PROTEIN GLYCOLIPID ANCHORS
    Anant K Menon; Fiscal Year: 2010
    ....
  54. Elucidating the molecular function of Hph1 in regulating metal ion homeostasis
    Francisco Pina; Fiscal Year: 2009
    ..of iron transport, Fet3 and Fet5, and a known regulator of Nramp-type metal ion transporters, Bsd2, in a membrane bound yeast two-hybrid assay...
  55. Jin Ye; Fiscal Year: 2014
    ..If these specific aims are achieved, we will have contributed novel information that will significantly enhance our understanding of the innate immune response. This new knowledge may reveal novel drug targets to treat HCV infection. ..
  56. 2010 Ligand Recognition and Molecular Gating Gordon Research Conference
    NANCY RYAN GRAY; Fiscal Year: 2010
    ..Understanding the structure and function of these membrane bound molecules is one of the most important goals of the 21st century, both for science and for development of new ..
  57. David L Stokes; Fiscal Year: 2014
    ..abstract_text> ..
  58. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  59. PATRICIA JEAN JOHNSON; Fiscal Year: 2016
    ....
  60. BIOGENESIS AND MOLECULAR PATHOGENESIS OF CFTR
    William R Skach; Fiscal Year: 2012
    ..abstract_text> ..
  61. Lucy A Waskell; Fiscal Year: 2014
    ....
  62. Role of MicroRNA mi R-33 in Controlling Cholesterol/Lipid Homeostasis
    Anders M Naar; Fiscal Year: 2010
    ..Our results show that miR-33 miRNAs target the ABCA1 cholesterol transporter for translational repression, resulting in lowered ABCA1 protein levels and decreased ..
  63. Biochemical Characterization of Cytochrome b5 Reductase in Candida albicans
    MARY JOLENE PATRICIA HOLLOWAY; Fiscal Year: 2010
    ..I will also learn new techniques used in biochemistry and proteomics, such as mass spectrometry, protein pull-down assays, and other methods involved in the characterization of proteins. ..
  64. Peter Walter; Fiscal Year: 2016
    ....
  65. Gary A Lorigan; Fiscal Year: 2016
    ..KCNE1 bind to the cytoplasmic domain of the KCNQ1 K+ channel? Which proposed structural model is correct for the E1/Q1 complex? Do disease-causing E1 or Q1 LQTS mutations alter the structure or binding mechanism of the E1/Q1 complex?! ..
  66. Structural Dynamics of Cardiac Calcium Transport Regulation
    NAA ADJELEY DROMOH ABLORH; Fiscal Year: 2013
    ..The findings of this research will provide the kind of detailed molecular information that is needed for the rational design of drugs, gene therapies, and other means of treating the failing heart. ..
  67. Gang Ren; Fiscal Year: 2016
    ..ApoA-I mediates cholesterol efflux via the cellular ATP-binding cassette transporter A1 (ABCA1), and produces nascent discoidal HDL particles that are then converted to spherical HDL by lecithin- cholesterol ..
  68. Structure of apolipoprotein A-I on defined states of HDL
    MICHAEL NOBUAKI ODA; Fiscal Year: 2010
    ..As a principal facilitator of RCT, HDL initiates cholesterol removal from peripheral tissues via the ABCA1 transporter cholesterol efflux pathway...
  69. ABCA1-mediated biogenesis of nascent HDL particles
    NICHOLAS LYSSENKO; Fiscal Year: 2013
    ..and extracellular apolipoprotein AI (apoAI) through a process mediated by ATP-binding cassette transporter A1 (ABCA1)...
  70. Unraveling the Genetic Architecture of Very High HDL cholesterol though Transcrip
    Michael Miller; Fiscal Year: 2010
    ..pedigrees with functional mutations elucidated in 3 genes: apolipoprotein A-1 (APOA1), ATP-binding cassette AI (ABCA1) and lecithin-cholesterol acyltransferase (LCAT)...
  71. John S Parks; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): ATP binding cassette transporter A1 (ABCA1) effluxes phospholipid (PL) and free cholesterol (FC) from cells, forming nascent high density lipoproteins (nHDL)...
  72. JESSICA OTIS; Fiscal Year: 2014
    ..Interestingly, in mice, CAV1 interacts with the ABC binding cassette transporter member 1 (ABCA1), which mediates cellular cholesterol efflux to high-density lipoproteins (HDL);mice lacking CAV1 have altered ..
  73. AIBP-Mediated Cholesterol Efflux and Angiogenesis
    Longhou Fang; Fiscal Year: 2013
    ..that the phenotype caused by the loss of AIBP was phenocopied by knockdown of cellular cholesterol transporters ABCA1 and ABCG1...
  74. Mechanisms of ethanol-induced neurodevelopmental effects
    Marina Guizzetti; Fiscal Year: 2011
    ..Specific Aims of the proposal are: 1) The investigation of the role of ABCA1 and ABCG1 in ethanol-induced cholesterol efflux...
  75. Mary G Sorci-Thomas; Fiscal Year: 2015
    ..MPO] and xanthine oxidase [XO]) to prevent LDL oxidation;2) or ATP binding cassette (ABC) transporter 1 (ABCA1)/ABCG1, lecithin cholesteryl acyl transferase (LCAT), cholesteryl ester transfer protein (CETP) and scavenger ..
  76. ABCG1 Function in Diabetes
    Catherine C Hedrick; Fiscal Year: 2012
    ..Aortic EC express ABCG1 and ABCA1, two key cholesterol transporters...
  77. NEW PATHWAY LIMITS CELLULAR CHOLESTEROL CONTENT
    Phoebe Fielding; Fiscal Year: 2004
    ..Caveolin forms a scaffold whose association with signal transduction proteins is regulated by FC. ABC 1 catalyses the transport of cellular PL to apolipoprotein A-1 (apo A-1) the major high density lipoprotein (HDL) ..
  78. Triazole hypersensitivity in Candida albicans
    Neeraj Chauhan; Fiscal Year: 2009
    ..6 billion, and the average per-patient attributable cost was $31,200 (5). The present study is aimed at the development and identification of newer antifungal drug targets which may be exploited in anti-fungal drug discovery. ..
  79. ApoA-I Helical Domains and Cardiovascular Aging
    JOHN BIELICKI; Fiscal Year: 2005
    ..Cellular cholesterol efflux mediated by apoA-I is dependent on the ATP-binding cassette transporter A1 (ABCA1) which is down regulated via a degradation pathway...
  80. Therapeutic potential-LXR ligands in Alzheimer's Disease
    Iliya Lefterov; Fiscal Year: 2005
    ..The ABCA1 transporter which is under the transcriptional control of LXRs, mediates CL efflux and secretion of excess CL from ..
  81. Novel Pathways of Cellular Cholesterol Efflux
    Alan Tall; Fiscal Year: 2005
    ..However, the mechanisms of the protective effect of HDL are incompletely understood. Mutations in ABCA1 result in low HDL and impaired efflux of cholesterol from macrophage foam cells to lipid-poor apoA-I...
  82. ABCA1 knock-in mouse model to study molecular pathology of Alzheimer's Disease
    Iliya Lefterov; Fiscal Year: 2007
    ..CL efflux and generation of HDL are mediated by ABCA1 membrane transporter which is transcriptionally controlled by Liver X nuclear Receptors (LXR)...
  83. Adenoviral Induced Acute Lung Injury and Surfactant
    Rama K Mallampalli; Fiscal Year: 2010
    ..The ATP-binding cassette transporter 1, ABCA1, has emerged as a key protein that directs basolateral trafficking of lipids to suitable acceptor proteins within ..