A20

Summary

Gene Symbol: A20
Description: TNF alpha induced protein 3
Alias: A20, AISBL, OTUD7C, TNFA1P2, tumor necrosis factor alpha-induced protein 3, OTU domain-containing protein 7C, tumor necrosis factor inducible protein A20, tumor necrosis factor, alpha induced protein 3, zinc finger protein A20
Species: human

Top Publications

  1. doi The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    Nat Immunol 9:254-62. 2008
  2. pmc Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice
    E G Lee
    Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, MC 6084, Chicago, IL 60637, USA
    Science 289:2350-4. 2000
  3. doi T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20
    Beatrice Coornaert
    Department of Molecular Biology, Ghent University, B 9052 Ghent, Belgium
    Nat Immunol 9:263-71. 2008
  4. ncbi A20 blocks endothelial cell activation through a NF-kappaB-dependent mechanism
    J T Cooper
    Sandoz Center for Immunobiology, Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 271:18068-73. 1996
  5. ncbi Neuroprotective effect of A20 on TNF-induced postischemic apoptosis
    Luyang Yu
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Room 901, Cell Biology Building, No 320 Yueyang Road, Shanghai 200031, China
    Neurochem Res 31:21-32. 2006
  6. pmc A20 (TNFAIP3) genetic alterations in EBV-associated AIDS-related lymphoma
    Lisa Giulino
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Blood 117:4852-4. 2011
  7. pmc The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN
    K Heyninck
    Department of Molecular Biology, Flanders Interuniversity Institute for Biotechnology, University of Ghent, B 9000 Ghent, Belgium
    J Cell Biol 145:1471-82. 1999
  8. ncbi De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling
    Ingrid E Wertz
    Department of Molecular Oncology, School of Medicine, University of California, Davis, Davis, California 95616, USA
    Nature 430:694-9. 2004
  9. ncbi Structure of the A20 OTU domain and mechanistic insights into deubiquitination
    David Komander
    Section of Structural Biology, The Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK
    Biochem J 409:77-85. 2008
  10. ncbi The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein
    A W Opipari
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109
    J Biol Chem 265:14705-8. 1990

Research Grants

  1. IDENTIFICATION OF NATURALLY PROCESSED SMANSONI PEPTIDES
    Philip Loverde; Fiscal Year: 2001
  2. Negative regulation of NF-kB and inflammation by TAX1BP1
    Edward W Harhaj; Fiscal Year: 2012
  3. Sherie L Morrison; Fiscal Year: 2015
  4. MEDIATORS AND MODIFIERS OF NF-kappaB IN INSULIN RESISTANCE
    Steven E Shoelson; Fiscal Year: 2010
  5. Immature intestinal NF-kB regulation, probiotics, and necrotizing enterocolitis
    Erika C Claud; Fiscal Year: 2013
  6. Asrar B Malik; Fiscal Year: 2016
  7. JAMES TILFORD ELDER; Fiscal Year: 2016
  8. Patrick M Gaffney; Fiscal Year: 2016
  9. Molecular mechanisms of TRAIL resistance in glioblastoma
    CHUNHAI CHARLIE HAO; Fiscal Year: 2013
  10. Lionel B Ivashkiv; Fiscal Year: 2016

Detail Information

Publications224 found, 100 shown here

  1. doi The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    Nat Immunol 9:254-62. 2008
    The ubiquitin-editing enzyme A20 is a critical negative regulator of inflammation and cytokine-mediated activation of the transcription factor NF-kappaB; however, little is known about the mechanisms of A20-mediated inactivation of ..
  2. pmc Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice
    E G Lee
    Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, MC 6084, Chicago, IL 60637, USA
    Science 289:2350-4. 2000
    b>A20 is a cytoplasmic zinc finger protein that inhibits nuclear factor kappaB (NF-kappaB) activity and tumor necrosis factor (TNF)-mediated programmed cell death (PCD)...
  3. doi T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20
    Beatrice Coornaert
    Department of Molecular Biology, Ghent University, B 9052 Ghent, Belgium
    Nat Immunol 9:263-71. 2008
    ..Here we show that T cell antigen receptor stimulation induced recruitment of the NF-kappaB inhibitor A20 into a complex of MALT1 and the adaptor protein Bcl-10, leading to MALT1-mediated processing of A20...
  4. ncbi A20 blocks endothelial cell activation through a NF-kappaB-dependent mechanism
    J T Cooper
    Sandoz Center for Immunobiology, Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 271:18068-73. 1996
    The A20 gene product is a novel zinc finger protein originally described as a tumor necrosis factor alpha (TNF)-inducible early response gene in human umbilical vein endothelial cells (HUVEC)...
  5. ncbi Neuroprotective effect of A20 on TNF-induced postischemic apoptosis
    Luyang Yu
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Room 901, Cell Biology Building, No 320 Yueyang Road, Shanghai 200031, China
    Neurochem Res 31:21-32. 2006
    ..TNF is critically involved in such neuronal apoptosis mediated by caspase pathways. A20 can inhibit TNF-induced apoptosis in many cell types...
  6. pmc A20 (TNFAIP3) genetic alterations in EBV-associated AIDS-related lymphoma
    Lisa Giulino
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Blood 117:4852-4. 2011
    b>A20, a negative regulator of NF-κB, has been implicated as a tumor suppressor gene in multiple types of B-cell lymphoma. AIDS-related lymphomas (ARLs) are high-grade B-cell lymphomas that are frequently associated with EBV infection...
  7. pmc The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN
    K Heyninck
    Department of Molecular Biology, Flanders Interuniversity Institute for Biotechnology, University of Ghent, B 9000 Ghent, Belgium
    J Cell Biol 145:1471-82. 1999
    The zinc finger protein A20 is a tumor necrosis factor (TNF)- and interleukin 1 (IL-1)-inducible protein that negatively regulates nuclear factor-kappa B (NF-kappaB)-dependent gene expression...
  8. ncbi De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling
    Ingrid E Wertz
    Department of Molecular Oncology, School of Medicine, University of California, Davis, Davis, California 95616, USA
    Nature 430:694-9. 2004
    ..to downregulate NF-kappaB transcriptional activity results in chronic inflammation and cell death, as observed in A20-deficient mice. A20 is a potent inhibitor of NF-kappaB signalling, but its mechanism of action is unknown...
  9. ncbi Structure of the A20 OTU domain and mechanistic insights into deubiquitination
    David Komander
    Section of Structural Biology, The Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK
    Biochem J 409:77-85. 2008
    The NF-kappaB (nuclear factor kappaB) regulator A20 antagonises IKK [IkappaB (inhibitor of kappaB) kinase] activation by modulating Lys63-linked polyubiquitination of cytokine-receptor-associated factors including TRAF2/6 (tumour-..
  10. ncbi The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein
    A W Opipari
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109
    J Biol Chem 265:14705-8. 1990
    We have previously identified in endothelial cells a gene product designated A20, that is rapidly and profoundly induced by tumor necrosis factor alpha (Dixit, V. M., Green, S., Sarma, V., Holzman, L. B., Wolf, F. W., O'Rourke, K...
  11. pmc A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation
    N Oshima
    Department of Internal Medicine II, Shimane University School of Medicine, Izumo, Shimane, Japan
    Clin Exp Immunol 159:185-98. 2010
    ..receptor (TLR)-mediated inflammatory responses and restore immune system balance, including the zinc-finger protein A20, a negative regulator of TLR signalling that inhibits nuclear factor kappa B (NF-kappaB) activity...
  12. pmc TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinases
    Kislay Parvatiyar
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 285:14999-5009. 2010
    ..Recent studies have described the ubiquitin-editing enzyme A20 as a negative regulator of IRF3 signaling by associating with TBK1-IKKi; however, the regulatory mechanism of A20 ..
  13. pmc African-derived genetic polymorphisms in TNFAIP3 mediate risk for autoimmunity
    James P Lodolce
    Department of Medicine, University of Chicago, Chicago, IL 60612, USA
    J Immunol 184:7001-9. 2010
    ..This is the first report of an association between TNFAIP3 polymorphisms and autoimmunity in African-Americans...
  14. doi Association of the TNFAIP3 rs5029939 variant with systemic sclerosis in the European Caucasian population
    P Dieude
    Universite Paris, Hopital Bichat Claude Bernard, APHP, France
    Ann Rheum Dis 69:1958-64. 2010
    ..TNFAIP3 encodes the ubiquitin-modifying enzyme, a key regulator of inflammatory signalling pathways. Convincing associations between TNFAIP3 variants and autoimmune diseases have been reported...
  15. pmc Functional evaluation of TNFAIP3 (A20) in rheumatoid arthritis
    L M Elsby
    Arthritis Research Campaign s Epidemiology Unit arc EU, Manchester Academic Health Sciences Centre, University of Manchester, United Kingdom
    Clin Exp Rheumatol 28:708-14. 2010
    ..To determine the protein expression of TNFAIP3 in synovium and to show the capability of 6q23 intergenic SNPs, associated with rheumatoid arthritis (RA) susceptibility, to influence TNFAIP3 gene transcription...
  16. pmc Role of the A20-TRAF6 axis in lipopolysaccharide-mediated osteoclastogenesis
    Guillaume Mabilleau
    Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, OX3 7LD Oxford, United Kingdom
    J Biol Chem 286:3242-9. 2011
    ..Recently, the role of the deubiquitinating protease A20 in regulating the LPS response in various organs was reported...
  17. doi Tumor suppressor TNFAIP3 (A20) is frequently deleted in Sézary syndrome
    F C M Braun
    Clinic for Internal Medicine C, University Greifswald, Greifswald, Germany
    Leukemia 25:1494-501. 2011
    ..We identified bi- and monoallelic deletions of the tumor necrosis factor-α-induced protein 3 gene (TNFAIP3; A20) in a high proportion of SS patients as well as biallelic A20 deletion in the SS-derived cell line SeAx...
  18. pmc A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells
    Kai Li He
    Immunobiology Center, Mount Sinai School of Medicine, New York, New York 10029, USA
    Mol Cell Biol 22:6034-45. 2002
    ..We show here that the zinc finger protein A20 is an NF-kappaB-inducible gene that can protect the IKKgamma-deficient cells from TNF-induced apoptosis ..
  19. doi TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas
    Keiichiro Honma
    Aichi Cancer Center Research Institute, Nagoya, Japan
    Blood 114:2467-75. 2009
    ..shown that chromosome 6q was frequently deleted in ocular marginal zone B-cell lymphoma and identified TNFAIP3/A20, a negative regulator of NF-kappaB pathways, as the primary target for 6q deletion...
  20. doi The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population
    Kenichi Shimane
    Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Arthritis Rheum 62:574-9. 2010
    ..The aim of this study was to assess the role of TNFAIP3 in the development of SLE and RA in Japanese subjects...
  21. ncbi Attenuated expression of A20 markedly increases the efficacy of double-stranded RNA-activated dendritic cells as an anti-cancer vaccine
    Karine Breckpot
    Laboratory of Molecular and Cellular Therapy, Department of Physiology Immunology, Medical School of the Vrije Universiteit Brussel, Brussels, Belgium
    J Immunol 182:860-70. 2009
    b>A20 is a zinc finger protein with ubiquitin-modifying activity...
  22. pmc Genome-wide association scan yields new insights into the immunopathogenesis of psoriasis
    J T Elder
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109 0932, USA
    Genes Immun 10:201-9. 2009
    ....
  23. doi A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility
    Yuta Kochi
    Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    Nat Genet 42:515-9. 2010
    ..Moreover, CCR6DNP was associated with susceptibility to Graves' and Crohn's diseases. These results suggest that CCR6 is critically involved in IL-17-driven autoimmunity in human diseases...
  24. pmc Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study
    Aya Kawasaki
    Molecular and Genetic Epidemiology Laboratory, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Arthritis Res Ther 12:R174. 2010
    ..involved in inhibition of nuclear factor-κB (NF-κB) activation by interacting with TNF alpha-induced protein 3, A20 (TNFAIP3), an established susceptibility gene to systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA)...
  25. pmc Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity
    Paul C Evans
    Molecular Immunology Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Biochem J 378:727-34. 2004
    ..The zinc-finger protein A20 has dual functions in inhibiting NF-kappaB activation and suppressing apoptosis...
  26. ncbi ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB
    Claudio Mauro
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Federico II, University of Naples, Via S Pansini, 5, 80131 Naples, Italy
    J Biol Chem 281:18482-8. 2006
    ..Here we identified ABIN-1 (A20 binding inhibitor of NF-kappaB) as a NEMO/IKKgamma-interacting protein...
  27. pmc ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development
    Shigeru Oshima
    Department of Medicine, University of California at San Francisco, 513 Parnassus Avenue, S 1057, San Francisco, California 94143 0451, USA
    Nature 457:906-9. 2009
    ..ABIN-1 (A20 binding and inhibitor of NF-kappaB) is a novel protein that is thought to inhibit NF-kappaB signalling...
  28. pmc Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus
    Robert R Graham
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Nat Genet 40:1059-61. 2008
    ..These results establish that variants near TNFAIP3 contribute to differential risk of SLE and RA...
  29. pmc A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
    Amy Strange
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Nat Genet 42:985-90. 2010
    ..Our findings implicate pathways that integrate epidermal barrier dysfunction with innate and adaptive immune dysregulation in psoriasis pathogenesis...
  30. pmc Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus
    Indra Adrianto
    Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    Nat Genet 43:253-8. 2011
    ..TNFAIP3, encoding the ubiquitin-modifying enzyme A20, is an established susceptibility locus for SLE...
  31. ncbi Combined expression of A1 and A20 achieves optimal protection of renal proximal tubular epithelial cells
    Uta Kunter
    Division of Vascular Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Kidney Int 68:1520-32. 2005
    ..In endothelial cells, the Bcl family member A1 and the zinc finger protein A20 have redundant and dual antiapoptotic and anti-inflammatory effects...
  32. doi A single-nucleotide polymorphism of the TNFAIP3 gene is associated with systemic lupus erythematosus in Chinese Han population
    Li Qiong Cai
    Department of Dermatology, Institute of Dermatology, The First Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, People s Republic of China
    Mol Biol Rep 37:389-94. 2010
    ..Our findings suggest that SNP rs2230926 in the TNFAIP3 might be a common genetic factor for SLE within different populations in terms of Chinese Han and European population...
  33. ncbi The A20 protein interacts with the Epstein-Barr virus latent membrane protein 1 (LMP1) and alters the LMP1/TRAF1/TRADD complex
    K L Fries
    Department of Microbiology and Immunology and the Lineberger Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
    Virology 264:159-66. 1999
    ..b>A20, which is induced by LMP1 through NF-kB, can block NF-kB activation from both domains of LMP1 and inhibit JNK ..
  34. ncbi Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin
    V M Dixit
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109
    J Biol Chem 265:2973-8. 1990
    ..Interleukin-1 beta and lipopolysaccharide are also potent inducers. Nuclear run-on studies revealed that in most cases induction by TNF is mediated largely at the transcriptional level...
  35. pmc The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation
    H Y Song
    Tularik, Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 93:6721-5. 1996
    ..Here we show that TRAF1 and TRAF2 interact with A20, a zinc finger protein, whose expression is induced by agents that activate NF-kappaB...
  36. ncbi 14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules
    C Vincenz
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 271:20029-34. 1996
    b>A20, a novel zinc finger protein, is an inhibitor of tumor necrosis factor-induced apoptosis. The mechanism by which A20 exerts its protective effect is currently unknown...
  37. ncbi A20, an inhibitor of cell death, self-associates by its zinc finger domain
    D De Valck
    Laboratory of Molecular Biology, University of Gent, Belgium
    FEBS Lett 384:61-4. 1996
    b>A20 is a primary response gene which is induced after monocyte adherence or cytokine stimulation of a variety of cells...
  38. ncbi A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins
    D De Valck
    Laboratory of Molecular Biology, Flanders Interuniversity Institute for Biotechnology, University of Ghent, K L Ledeganckstraat 35, Ghent, B 9000, Belgium
    Biochem Biophys Res Commun 238:590-4. 1997
    The A20 protein, which belongs to a class of Cys2/Cys2 zinc finger proteins, has been characterized as an inhibitor of NF-kappaB activation...
  39. ncbi The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6
    K Heyninck
    Department of Molecular Biology, Flanders Interuniversity Institute for Biotechnology and University of Ghent, Belgium
    FEBS Lett 442:147-50. 1999
    The zinc finger protein A20 is encoded by an immediate early response gene whose expression is induced by different inflammatory stimuli, including interleukin-1 (IL-1)...
  40. ncbi The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases
    D De Valck
    Department of Molecular Biology, Flanders Interuniversity Institute for Biotechnology and University of Gent, Belgium
    Oncogene 18:4182-90. 1999
    b>A20 is a Cys2/Cys2 zinc finger protein which is induced by a variety of inflammatory stimuli and which has been characterized as an inhibitor of cell death by a yet unknown mechanism...
  41. ncbi Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation
    S Q Zhang
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel
    Immunity 12:301-11. 2000
    ..It also induces binding of NEMO to the signaling inhibitor A20, and recruitment of A20 to the receptor...
  42. ncbi Structure-function analysis of the A20-binding inhibitor of NF-kappa B activation, ABIN-1
    Karen Heyninck
    Department of Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, Flanders Interuniversity Institute for Biotechnology, Ghent University, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    FEBS Lett 536:135-40. 2003
    ..Among others, the NF-kappa B-dependent zinc finger protein A20 is involved in the negative feedback regulation of NF-kappa B activation in response to tumor necrosis ..
  43. ncbi A20 inhibits toll-like receptor 2- and 4-mediated interleukin-8 synthesis in airway epithelial cells
    Yasuhiro Gon
    First Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
    Am J Respir Cell Mol Biol 31:330-6. 2004
    The zinc finger protein A20 is encoded by an immediate early response gene and acts as an inhibitor of nuclear factor (NF)-kappaB-dependent gene expression induced by different stimuli, including tumor necrosis factor-alpha (TNF-alpha) ..
  44. ncbi A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation
    Soizic Daniel
    Department of Surgery and Medicine, 99 Brookline Ave, Boston MA 02215, USA
    Blood 104:2376-84. 2004
    b>A20 is a stress response gene in endothelial cells (ECs)...
  45. ncbi The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
    David L Boone
    Department of Medicine, University of California at San Francisco, San Francisco, California 94143 0451, USA
    Nat Immunol 5:1052-60. 2004
    b>A20 is a cytoplasmic protein required for the termination of tumor necrosis factor (TNF)-induced signals...
  46. ncbi Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20
    Rongtuan Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, and Department of Microbiology, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 281:2095-103. 2006
    ..In the present study, we demonstrate that the NF-kappaB-inducible, anti-apoptotic protein A20 efficiently blocks RIG-I-mediated activation of NF-kappaB-, IRF-3-, and IRF-7-dependent promoters but only weakly ..
  47. ncbi A new role for the anti-apoptotic gene A20 in angiogenesis
    Hsiao W Chng
    Department of Oncology, King s College London School of Medicine, The Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
    Exp Cell Res 312:2897-907. 2006
    b>A20 is a negative regulator of NF-kappaB activation and thus a potential therapeutic tool for the treatment of diseases where apoptosis and/or inflammatory responses are part of the pathogenic process...
  48. ncbi Tag polymorphisms at the A20 (TNFAIP3) locus are associated with lower gene expression and increased risk of coronary artery disease in type 2 diabetes
    Watip Boonyasrisawat
    Section on Genetics and Epidemiology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 56:499-505. 2007
    b>A20 or tumor necrosis factor (TNF)-induced protein 3 (TNFAIP3) is a negative regulator of nuclear factor-kappaB (NF-kappaB)...
  49. ncbi TNFAIP3 is the target gene of chromosome band 6q23.3-q24.1 loss in ocular adnexal marginal zone B cell lymphoma
    Keiichiro Honma
    Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan
    Genes Chromosomes Cancer 47:1-7. 2008
    ..TNFAIP3 is an inhibitor of NF-kB signaling so that loss of this gene may play an important role in lymphomagenesis and suggests that TNFAIP3 may act as a tumor suppressor gene in ocular adnexal marginal zone B cell lymphoma...
  50. pmc Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
    Robert M Plenge
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 39:1477-82. 2007
    ..We show that these two SNP associations are statistically independent, are each reproducible in the comparison of our data and WTCCC data, and define risk and protective haplotypes for rheumatoid arthritis at 6q23...
  51. pmc Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20
    Su Chang Lin
    Department of Biochemistry, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Mol Biol 376:526-40. 2008
    ..b>A20 is a specific feedback inhibitor of NF-kappaB activation in these pathways that possesses dual ubiquitin-editing ..
  52. pmc Common variants at CD40 and other loci confer risk of rheumatoid arthritis
    Soumya Raychaudhuri
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:1216-23. 2008
    ..1 x 10(-7) overall), CDK6 (rs42041, P = 0.010 replication, P = 4.0 x 10(-6) overall), PRKCQ (rs4750316, P = 0.0078 replication, P = 4.4 x 10(-6) overall), and KIF5A-PIP4K2C (rs1678542, P = 0.0026 replication, P = 8.8 x 10(-8) overall)...
  53. doi Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus
    E Y M G Fung
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Genes Immun 10:188-91. 2009
    ..70 x 10(-3) to 3.20 x 10(-5). These findings extend our knowledge of susceptibility locus sharing across different autoimmune diseases, and provide convincing evidence that the RA/SLE locus 6q23/TNFAIP3 is a newly identified T1D locus...
  54. pmc The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, Miller School of Medicine, The University of Miami, Miami, FL 33136, USA
    EMBO J 28:513-22. 2009
    ..RNF11 interacted with the NF-kappaB inhibitor A20 and its regulatory protein TAX1BP1 in a stimulus-dependent manner...
  55. pmc Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus
    Stacy L Musone
    Cardiovascular Research Institute, Department of Medicine, University of California San Francisco, San Francisco, California 94143, USA
    Nat Genet 40:1062-4. 2008
    The TNFAIP3 (tumor necrosis factor alpha-induced protein 3) gene encodes a ubiquitin editing enzyme, A20, that restricts NF-kappaB-dependent signaling and prevents inflammation...
  56. pmc Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways
    Rajan P Nair
    Department of Dermatology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Genet 41:199-204. 2009
    ..Our results expand the catalog of genetic loci implicated in psoriasis susceptibility and suggest priority targets for study in other auto-immune disorders...
  57. pmc The NF-{kappa}B negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas
    Urban Novak
    Institute for Cancer Genetics, Departments of Pathology and Genetics and Development, and The Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
    Blood 113:4918-21. 2009
    ..deletions of the chromosomal band 6q23, involving the tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) gene, a negative regulator of NF-kappaB, were described in ocular adnexal MZL, suggesting a role for A20 as a ..
  58. pmc Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-kappaB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility
    Rebeca Dieguez-Gonzalez
    Laboratorio de Investigacion 2 and Rheumatology Unit, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain
    Arthritis Res Ther 11:R42. 2009
    ..We hypothesized that there is a similar association with RA, including polymorphisms in TNFAIP3 and the intergenic region...
  59. pmc Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains
    David Komander
    Division of Protein and Nucleic Acid Chemistry, Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    EMBO Rep 10:466-73. 2009
    ..Our results highlight remarkable specificity determinants within the ubiquitin system...
  60. pmc A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme
    Barbara A Malynn
    Program in Biomedical Sciences, Program in Biological Sciences, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 206:977-80. 2009
    ..A new study identifies somatic mutations in TNFAIP3, the gene encoding the NF-kappaB inhibitor A20, in Hodgkin lymphomas and primary mediastinal lymphomas...
  61. pmc TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma
    Roland Schmitz
    Institute of Cell Biology Cancer Research, Medical School, University of Duisburg Essen, 45122 Essen, Germany
    J Exp Med 206:981-9. 2009
    ..NF-kappaB activation through various stimuli is negatively regulated by the zinc finger protein A20. To determine whether A20 contributes to the pathogenesis of cHL, we sequenced TNFAIP3, encoding A20, in ..
  62. pmc Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations
    J S Bates
    Oklahoma Medical Research Foundation, Arthritis and Immunology Research Program, Oklahoma City, OK 73104, USA
    Genes Immun 10:470-7. 2009
    TNFAIP3 encodes the ubiquitin-modifying enzyme, A20, a key regulator of inflammatory signaling pathways. We previously reported association between TNFAIP3 variants and systemic lupus erythematosus (SLE)...
  63. doi Frequent inactivation of A20 in B-cell lymphomas
    Motohiro Kato
    Cancer Genomics Project, Department of Pediatrics, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Nature 459:712-6. 2009
    b>A20 is a negative regulator of the NF-kappaB pathway and was initially identified as being rapidly induced after tumour-necrosis factor-alpha stimulation...
  64. doi A20 is overexpressed in glioma cells and may serve as a potential therapeutic target
    Qingdong Guo
    The Fourth Military Medical University, Xijing Hospital, Department of Neurosurgery, Xi an 710032, China
    Expert Opin Ther Targets 13:733-41. 2009
    b>A20 is a TNF-inducible primary response gene, which has been found to have antiapoptotic function in several cancer cells...
  65. doi A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains
    Michael Duwel
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Toxicology, Neuherberg, Germany
    J Immunol 182:7718-28. 2009
    ..Further, the ubiquitin-editing enzyme A20 was recently suggested to suppress T cell activation, but molecular targets for A20 remain elusive...
  66. pmc Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis
    Sampath Prahalad
    Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Arthritis Rheum 60:2124-30. 2009
    ....
  67. doi The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology
    Lars Vereecke
    Department for Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent B 9052, Belgium
    Trends Immunol 30:383-91. 2009
    ..In this context, the intracellular ubiquitin-editing protein A20 (also known as Tumor Necrosis Factor Alpha-Induced Protein 3 or TNFAIP3) is a key player in the negative feedback ..
  68. pmc Mutations in the genes coding for the NF-κB regulating factors IκBα and A20 are uncommon in nodular lymphocyte-predominant Hodgkin's lymphoma
    Martin A Schumacher
    Institute of Cell Biology Cancer Research, Medical School, University of Duisburg Essen, Essen, Germany
    Haematologica 95:153-7. 2010
    ..mutations in the NFKBIA and TNFAIP3 genes, coding for the negative NF-kappaB regulators IkappaBalpha and A20, respectively, contribute to NF-kappaB activation...
  69. pmc Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects
    Kai Wang
    Center for Applied Genomics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Hum Mol Genet 19:2059-67. 2010
    ....
  70. pmc Association of TNFAIP3 polymorphism with susceptibility to systemic lupus erythematosus in a Japanese population
    Aya Kawasaki
    Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305 8575, Japan
    J Biomed Biotechnol 2010:207578. 2010
    ..013). These results indicated that TNFAIP3 is a susceptibility gene to SLE both in the Caucasian and Asian populations...
  71. pmc Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne
    Anja Bremm
    Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
    Nat Struct Mol Biol 17:939-47. 2010
    ..Our data highlight the intrinsic specificity of the ubiquitin system that extends to Lys11-linked chains and emphasize that differentially linked polyubiquitin chains must be regarded as independent post-translational modifications...
  72. doi Cleavage by MALT1 induces cytosolic release of A20
    Claire Malinverni
    Novartis Institutes for BioMedical Research, Forum 1, Novartis Campus, CH 4056 Basle, Switzerland
    Biochem Biophys Res Commun 400:543-7. 2010
    The MALT1 paracaspase has arginine-directed proteolytic activity. A20 is a dual ubiquitin-editing enzyme involved in termination of NF-κB signaling...
  73. pmc Rare variation at the TNFAIP3 locus and susceptibility to rheumatoid arthritis
    John Bowes
    Arthritis Research UK, Epidemiology Unit, University of Manchester, Manchester, UK
    Hum Genet 128:627-33. 2010
    ....
  74. pmc Regulation of inflammatory and antiviral signaling by A20
    Kislay Parvatiyar
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, 1550 NW 10 Avenue, Miami, FL 33136, USA
    Microbes Infect 13:209-15. 2011
    The deubiquitinating enzyme A20 (also known as TNFAIP3) is essential for maintaining immune homeostasis. A20 is a key regulator of inflammatory, antiviral and apoptotic signaling pathways...
  75. pmc Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression
    Yanbao Xiong
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 286:7905-16. 2011
    ..Deficiencies in these signaling events in LPS-tolerant cells coincided with increased expression of A20, an essential deubiquitination enzyme, and sustained A20-IRAK1 associations...
  76. doi A20, ABIN-1/2, and CARD11 mutations and their prognostic value in gastrointestinal diffuse large B-cell lymphoma
    Gehong Dong
    Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    Clin Cancer Res 17:1440-51. 2011
    ..Activating mutations of CARD11 and inactivating mutations of A20 are frequent events in DLBCL...
  77. pmc Sequencing of TNFAIP3 and association of variants with multiple autoimmune diseases
    S L Musone
    Cardiovascular Research Institute and Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA
    Genes Immun 12:176-82. 2011
    The TNFAIP3 locus at 6q23, encoding A20, has been associated with multiple autoimmune diseases (AIDs)...
  78. doi Genetic relationships between A20/TNFAIP3, chronic inflammation and autoimmune disease
    Lars Vereecke
    Department for Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, VIB, B 9052 Ghent, Belgium
    Biochem Soc Trans 39:1086-91. 2011
    b>A20 [also known as TNFAIP3 (tumour necrosis factor α-induced protein 3)] restricts and terminates inflammatory responses through modulation of the ubiquitination status of central components in NF-κB (nuclear factor κB), IRF3 (..
  79. pmc Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis
    Gianna Elena Hammer
    Department of Medicine, University of California at San Francisco, San Francisco, California, USA
    Nat Immunol 12:1184-93. 2011
    ..Here we show that mice lacking the ubiquitin-editing molecule A20 specifically in DCs spontaneously showed DC activation and population expansion of activated T cells...
  80. pmc TNFAIP3 maintains intestinal barrier function and supports epithelial cell tight junctions
    Lauren E Kolodziej
    Department of Medicine, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 6:e26352. 2011
    ..These in vivo and in vitro studies support the role of TNFAIP3 in promoting intestinal epithelial barrier integrity and demonstrate its novel ability to maintain intestinal homeostasis through tight junction protein regulation...
  81. pmc Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population
    Hua Zhong
    State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China
    Arthritis Res Ther 13:R186. 2011
    ..To better understand the genetic risk factors of SLE, we investigated the associations of seven SLE susceptibility genes in a Chinese population, including FCGR3A, FCGR2A, TNFAIP3, TLR9, TREX1, ETS1 and TNIP1...
  82. pmc Direct, noncatalytic mechanism of IKK inhibition by A20
    Brian Skaug
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Mol Cell 44:559-71. 2011
    b>A20 is a potent anti-inflammatory protein that inhibits NF-κB, and A20 dysfunction is associated with autoimmunity and B cell lymphoma...
  83. pmc A20 inactivation in ocular adnexal MALT lymphoma
    Yingwen Bi
    Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Haematologica 97:926-30. 2012
    Recent studies showed A20 inactivation by deletion, mutation and promoter methylation in ocular adnexal mucosa-associated lymphoid tissue lymphoma...
  84. doi Targeting A20 enhances TRAIL-induced apoptosis in hepatocellular carcinoma cells
    Bingfei Dong
    Department of Hepatopancreatobiliary Surgery, First Hospital of Jilin University, Jilin University, 71 Xinmin Street, Changchun 130021, China
    Biochem Biophys Res Commun 418:433-8. 2012
    b>A20 was initially identified as a primary gene product following TNF α treatment in human umbilical vein endothelial cells...
  85. doi Expression of A20 is reduced in pancreatic cancer tissues
    Qing Wang
    Department of General Surgery, Tangdu Hospital of the Fourth Military Medical University, Xi an 710038, Shaanxi, China
    J Mol Histol 43:319-25. 2012
    b>A20 protein plays essential roles in tumorigenesis, but its value for diagnosis of pancreatic cancer remains unclear. Our aim was to determine whether A20 is a potential biomarker for the diagnosis of pancreatic cancer...
  86. doi Brief report: candidate gene study in systemic sclerosis identifies a rare and functional variant of the TNFAIP3 locus as a risk factor for polyautoimmunity
    Eugénie Koumakis
    Paris Descartes University, Inserm U1016, Institut Cochin, and Cochin Hospital, AP HP, Paris, France
    Arthritis Rheum 64:2746-52. 2012
    ..The present study was undertaken to investigate whether rare variants of TNFAIP3 and TREX1 are also associated with SSc...
  87. doi Probiotics promote endocytic allergen degradation in gut epithelial cells
    Chun Hua Song
    Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China
    Biochem Biophys Res Commun 426:135-40. 2012
    ..The ubiquitin E3 ligase A20 (A20) plays a role in the endocytic protein degradation in the cells...
  88. pmc A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7
    Kelly Verhelst
    Department for Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, VIB, Ghent, Belgium
    EMBO J 31:3845-55. 2012
    ..However, the mechanisms that regulate linear ubiquitination are still unknown. Here, we show that A20 is rapidly recruited to NEMO and LUBAC upon TNF stimulation and that A20 inhibits LUBAC-induced NF-κB activation ..
  89. pmc Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation
    Fuminori Tokunaga
    Laboratory of Molecular Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan
    EMBO J 31:3856-70. 2012
    ..However, the regulatory mechanism of LUBAC-mediated NF-κB activation remains elusive. Here, we show that A20 suppresses LUBAC-mediated NF-κB activation by binding linear polyubiquitin via the C-terminal seventh zinc finger (..
  90. pmc Deletion of the TNFAIP3/A20 gene detected by FICTION analysis in classical Hodgkin lymphoma
    Junko Nomoto
    Hematology Division, National Cancer Center Hospital, Tokyo, Japan
    BMC Cancer 12:457. 2012
    The TNFAIP3 gene, which encodes a ubiquitin-modifying enzyme (A20) involved in the negative regulation of NF-κB signaling, is frequently inactivated by gene deletions/mutations in a variety of B-cell malignancies...
  91. doi TNFAIP3 gene polymorphisms confer risk for Behcet's disease in a Chinese Han population
    Hong Li
    The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, and Chongqing Eye Institute, Chongqing 400016, People s Republic of China
    Hum Genet 132:293-300. 2013
    ..53-0.87]) and A allele (p (c) = 0.025, OR [95% CI] 0.72 [0.57-0.91]) were observed in BD patients. This study identified one strong risk SNP rs9494885 and two weak risk SNPs rs10499194 and rs7753873 of TNFAIP3 in Chinese Han BD patients...
  92. pmc Involvement of A20 in the molecular switch that activates the non-canonical NF-кB pathway
    Noritaka Yamaguchi
    Division of Cellular and Molecular Biology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato ku, Tokyo, Japan
    Sci Rep 3:2568. 2013
    ..Here, we show that A20, a ubiquitin-editing enzyme, promotes efficient activation of the non-canonical pathway independent of its ..
  93. ncbi Identification of Naf1/ABIN-1 among TNF-alpha-induced expressed genes in human synoviocytes using oligonucleotide microarrays
    Joanne Gallagher
    The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    FEBS Lett 551:8-12. 2003
    ..The regulation of Nef-associated factor-1 (Naf1), an A20-binding, nuclear factor kappa B (NFkappaB) inhibitory protein was probed further given its putative role as an ..
  94. ncbi A20/TNFAIP3, a new estrogen-regulated gene that confers tamoxifen resistance in breast cancer cells
    J A Vendrell
    CNRS UMR 5160, Centre de Pharmacologie et Biotechnologie pour la Santé, Faculte de Pharmacie, Montpellier, France
    Oncogene 26:4656-67. 2007
    The zinc-finger protein A20/TNFAIP3, an inhibitor of nuclear factor-kappaB (NF-kappaB) activation, has been shown to protect MCF-7 breast carcinoma cells from TNFalpha-induced apoptosis...
  95. pmc Strain-ecotype specificity in Sinorhizobium meliloti-Medicago truncatula symbiosis is correlated to succinoglycan oligosaccharide structure
    Senay Simsek
    Whistler Center for Carbohydrate Research, Purdue University, 745 Agriculture Mall Drive, West Lafayette, IN 47907 2009, USA
    J Bacteriol 189:7733-40. 2007
    ..meliloti Rm41 and NRG247 are Fix+ (compatible) on M. truncatula A20 and Fix- (incompatible) on M. truncatula A17, the Fix phenotypes are reversed with S...
  96. ncbi Fas-mediated activation of phospholipase D is coupled to the stimulation of phosphatidylcholine-specific phospholipase C in A20 cells
    J S Han
    College of Medicine, Hanyang University, Seoul, 133 791, Korea
    Arch Biochem Biophys 367:233-9. 1999
    The activation of phospholipase D in murine B cell lymphoma A20 cells treated with anti-Fas monoclonal antibody has been investigated. Fas cross-linking resulted in a both dose- and time-dependent increases in phospholipase D activity...
  97. pmc Myosin light chain-activating phosphorylation sites are required for oogenesis in Drosophila
    P Jordan
    Centre de Genetique Moleculaire, 91198 Gif sur Yvette, France
    J Cell Biol 139:1805-19. 1997
    ..In addition, numerous aggregates of myosin heavy chain accumulate in the sqh null cells. Mutant sqh transgene sqh-A20, A21 in which both serine-21 and threonine-20 have been replaced by alanines behaves in most respects identically ..
  98. ncbi Associations among serum lipoprotein(a) levels, apolipoprotein(a) phenotypes, and myocardial infarction in patients with extremely low and high levels of serum lipoprotein(a)
    K Saku
    Department of Internal Medicine, Fukuoka University School of Medicine, Japan
    Jpn Circ J 63:659-65. 1999
    ..higher percentages of smaller isoforms (A1-A4, A5-A9) and decreasingly lower percentages of large isoforms (A10-A20, A21-A25) compared to Group I. An apparent inverse relationship existed between Lp(a) and the apo(a) phenotype...
  99. pmc Mengovirus and encephalomyocarditis virus poly(C) tract lengths can affect virus growth in murine cell culture
    L R Martin
    Institute for Molecular Virology and Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Virol 74:3074-81. 2000
    ..Replication and cytopathic studies with four hematopoietically derived cell lines (CH2B, RAW 264.7, A20.J, and P815) and two murine fibroblast cell lines [L929 and L(Y)] demonstrated that several of these cell types ..
  100. ncbi An essential role of antigen-presenting cell/T-helper type 1 cell-cell interactions in draining lymph node during complete eradication of class II-negative tumor tissue by T-helper type 1 cell therapy
    Kenji Chamoto
    Division of Immunoregulation, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan
    Cancer Res 66:1809-17. 2006
    ..of ovalbumin (OVA)-specific T helper type 1 (Th1) cells into mice bearing MHC class II+ OVA-expressing tumor cells (A20-OVA) causes complete tumor rejection...

Research Grants70

  1. IDENTIFICATION OF NATURALLY PROCESSED SMANSONI PEPTIDES
    Philip Loverde; Fiscal Year: 2001
    ..We had previously presented data showing that peptides eluted from MHC class II molecules of A20 cell line pulsed with NP40 extract of schistosomule stimulate a proliferative response in bulk lymph node cells ..
  2. Negative regulation of NF-kB and inflammation by TAX1BP1
    Edward W Harhaj; Fiscal Year: 2012
    ..LPS) is normally transient due to the upregulation of multiple negative feedback inhibitors, including IkBa and A20 (also known as TNFAIP3)...
  3. Sherie L Morrison; Fiscal Year: 2015
    ..the in vivo efficacy of anti-CD20-mIFNa and anti-CD20-mIFN[unreadable] against 38C13-huCD20 in C3H mice and A20-huCD20 in BALB/c huCD20-transgenic mice...
  4. MEDIATORS AND MODIFIERS OF NF-kappaB IN INSULIN RESISTANCE
    Steven E Shoelson; Fiscal Year: 2010
    ..As the subject of this proposal we also see constitutive, NF-kappaB dependent expression of A20, IKKi/epsilon, and IkappaBzeta, in fat and liver of obese/HFD rodent models...
  5. Immature intestinal NF-kB regulation, probiotics, and necrotizing enterocolitis
    Erika C Claud; Fiscal Year: 2013
    ..that compared to mature IEC, immature IEC have differences in regulation of both inhibitory kappaB alpha and A20 - key NF-kB down-regulatory proteins...
  6. Asrar B Malik; Fiscal Year: 2016
    ..repressor protein, Dream, as a negative master regulator of the dual function deubiquitinating/E3 ligase enzyme A20, which has a central role in preventing NF-kappaB activation. In Project 4, Dr. Y. Y. Zhao, P.I...
  7. JAMES TILFORD ELDER; Fiscal Year: 2016
    ..The results of this research are also likely to be relevant to other autoimmune diseases. ..
  8. Patrick M Gaffney; Fiscal Year: 2016
    ..published work from our laboratory has identified and confirmed a convincing novel association with TNFAIP3 (A20), a critical negative regulator of NF-kB signaling...
  9. Molecular mechanisms of TRAIL resistance in glioblastoma
    CHUNHAI CHARLIE HAO; Fiscal Year: 2013
    ..Specifically, the Preliminary Studies identify RIP (receptor-interacting protein) and A20, a RIP ubiquitin enzyme in the PLAC and show that TRAIL treatment leads to the RIP ubiquitination and caspase-8 ..
  10. Lionel B Ivashkiv; Fiscal Year: 2016
    ..include linkage of ITGAM that encodes the 1M component of the 1M22 integrin, FCGR2A (Fc3RIIA), and TNFAIP3 (A20) with SLE and/or RA...
  11. Therapeutics that target processivity complex proteins of pox and other viruses
    ROBERT PAUL RICCIARDI; Fiscal Year: 2013
    ..that processive DMA synthesis of vaccinia virus (W) requires three proteins, an E9 DMA polymerase and the A20, D4R processivity factors...
  12. Paula Traktman; Fiscal Year: 2016
    ..elucidate the replication of vaccinia virus by focusing on the following three aims: AIM I: Analysis of the E9/A20/UDG polymerase holoenzyme in replication and repair...
  13. Improved idiotype immunotherapy for lymphoma by RNA vaccine delivery
    ALISON ANNE MCCORMICK; Fiscal Year: 2010
    ..RNA constructs to determine the efficacy of RNA based idiotype vaccines in two murine models of NHL (38C13 and A20)...
  14. RICARDO C AGUIAR; Fiscal Year: 2016
    ..Finally, as the potential of inhibiting and restoring miRNA levels with therapeutic intent is becoming a reality, our studies may provide a blueprint for testing this concept in cancer. ..
  15. Developing novel adjuvants for HIV vaccination
    Si Yi Chen; Fiscal Year: 2013
    ..found that the negative regulators of proinflammatory signaling, such as the zinc-finger ubiquitin-modifying enzyme A20 and suppressor of cytokine signaling 1 (SOCS1), play critical roles in limiting the immunostimulatory potency of ..
  16. Innate immune regulation of inflammation and adaptive immunity
    Anthony L DeFranco; Fiscal Year: 2012
    ..In Project #2, Dr. Ma will analyze the role of the ubiquitin-modifying regulator A20 in dendritic cells for restraining TLR responses and preventing inflammatory disease. In Project #3, Dr...
  17. Improved liver function and regeneration with A20
    Christiane Ferran; Fiscal Year: 2013
    ..We have identified the 7-Zinc finger protein A20 as a critical component of the protective and regenerative responses of hepatocytes in that it protects ..
  18. A20 Gene Polymorphisms in LDLT
    Christiane Ferran; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Our longstanding work demonstrates that A20 (tnfaip3) enhances the liver's combined anti-inflammatory, anti- apoptotic, and anti-oxidant response to injury, and promotes hepatocyte proliferation ..
  19. Elizabeth A Pomfret; Fiscal Year: 2014
    ..In animal models, the A20 gene complex has been shown to be involved in hepatic regeneration after lethal hepatectomy, and in humans, ..
  20. Identification of Psoriatic Arthritis Genes
    JAMES TILFORD ELDER; Fiscal Year: 2013
    ..Its cause is not well understood. Identification of genes that increase risk of psoriatic arthritis will help us unlock the secrets of this troubling disease, and identify targets for more specific and effective therapy. ..
  21. CD20 DNA VACCINATION FOR B-CELL LYMPHOMA
    Maria Lia Palomba; Fiscal Year: 2010
    ..form of the human CD20 cDNA, administered to mice via particle bombardment and followed by a lethal challenge of A20 murine lymphoma cells, resulted in cellular immune responses against the human and mouse CD20 (therefore breaking ..
  22. Bioinformatics and Population Genetics to Identify Rheumatoid Arthritis Genes
    Soumya Raychaudhuri; Fiscal Year: 2012
    ..abstract_text> ..
  23. Edward W Harhaj; Fiscal Year: 2016
    ..of cytokine-mediated NF-kB signaling by functioning as an essential subunit for the ubiquitin-editing enzyme A20. We hypothesize that Tax targets TAX1BP1 as part of a mechanism to promote persistent NF-kB activation...
  24. JAMES TILFORD ELDER; Fiscal Year: 2016
    ..Its cause is not well understood. Identification of genes that increase risk of psoriasis will help us unlock the secrets of this troubling disease, and identify targets for more specific and effective therapy. ..
  25. Dissection of two rheumatoid arthritis risk loci from genome-wide studies
    Michael B Brenner; Fiscal Year: 2013
    ..Moreover, this approach will be applicable to other RA susceptibility genes as they are identified. ..
  26. AVERIL I MA; Fiscal Year: 2016
    ..b>A20 is an enzyme that potently restricts signals from microbial sensing pathways, including Toll-like receptor (TLR), ..
  27. A20 (TNFAIP3) Regulation of Intestinal Immune Homeostasis
    TIMOTHY THEN CHIOH LU; Fiscal Year: 2012
    ..The ubiquitin-modifying protein A20 (also known as TNFa induced protein 3, TNFAIP3) is a critical regulator of NF-kB signaling as demonstrated by A20-..
  28. Tolerance to TLR Ligands in the Intestinal Epithelium
    Anatoly V Grishin; Fiscal Year: 2010
    ..We have found that bacterial lipopolysaccharide (LPS)-induced expression of the A20 deubiquitinase is necessary and sufficient for the development of tolerance to LPS, the TLR4 ligand, in enterocytes...
  29. Genotyping the NPF Biobank for Psoriasis Susceptibility Genes
    JAMES TILFORD ELDER; Fiscal Year: 2010
    ..Its cause is not well understood. Identification of genes that increase risk of psoriasis will help us unlock the secrets of this troubling disease, and identify targets for more specific and effective therapy. ..
  30. AVERIL I MA; Fiscal Year: 2014
    ..We have recently found that A20 is a ubiquitin modifying enzyme that restricts toll-like receptor (TLR) induced signals...
  31. Patrick M Gaffney; Fiscal Year: 2016
    ..We are confident that these rich datasets and our cumulative experience uniquely position our group to lead the effort in causal variant discovery in SLE. ..
  32. Andrei E Medvedev; Fiscal Year: 2014
    ..of IRAK1 and TRAF-6;suppressed interactions of ubiquitinated IRAK1 with TRAF6 and IKK3;and increased expression of A20, a key deubiquitinating enzyme...
  33. Discovering Gastrokine-1: A Novel Peptide Regulator of Intestinal Permeability
    Shirley C Paski; Fiscal Year: 2011
    ..The proposed research will test the effect of gastrokine-1 at improving gastrointestinal barrier function and treating inflammatory diarrheal diseases. ..
  34. ANITA HJELMELAND; Fiscal Year: 2014
    ..We now demonstrate that the cell survival regulator A20/Tumor Necrosis Factor a Inducible Protein 3 is a glioma stem cell target which contributes to glioma growth...
  35. Overcoming Immune Suppression to Enhance Tumor Vaccine Efficacy
    Si Yi Chen; Fiscal Year: 2013
    ..In our recent studies supported by the current grant (1R01CA090427;7/2002-6/2007), we found that A20, a negative regulator of the TLR and TNFR signaling pathways, critically restricts the maturation, cytokine ..
  36. ALEXANDER KEITH STEWART; Fiscal Year: 2016
    ....
  37. Wilson Liao; Fiscal Year: 2014
    ..This will provide an ideal setting for the candidate's maturation into an independent investigator. ..
  38. The Role of Toll-Like Receptors in Cancer Immunotherapy
    Yiping Yang; Fiscal Year: 2009
    ..In a murine model of A20 lymphoma, we have demonstrated that tumor-specific CDS tolerance is mediated by CD4+CD25+ regulatory T (TReg) cells ..
  39. Xiao Tong Song; Fiscal Year: 2015
    ..will take advantage of our preliminary studies in which we have demonstrated that silencing the negative regulator A20 in DC can overcome Treg mediated immune suppression resulting in potent antitumor responses in the B16 model...
  40. DESIGN AND EFFICACY OF ANTI LYMPHOMA DNA VACCINE
    SWAPAN GHOSH; Fiscal Year: 2000
    ..of the above scFv variants after in vitro transfection into two different antigen-presenting cells: P815, and A20; and (3) Determine the in vivo effects of these scFv variants on the nature, magnitude and specificity of humoral ..
  41. NEW GENES AND PATHWAYS INVOLVED IN ATHEROSCLEROSIS
    ALAN RICHARD TALL; Fiscal Year: 2010
    ..Breslow will explore the hypothesis that the modulation of TNF signaling by different genetic variants of the A20 gene results in altered vascular cell apoptosis and atherosclerosis, and will seek to identify additional ..
  42. MEMBRANE RECEPTOR TRAFFICKING AND ANTIGEN PROCESSING
    Richard Mitchell; Fiscal Year: 1999
    ..to mIg's which rapidly intend upon antigen ligation, but do not access the antigen processing compartment in murine A20 cells, even if the mIg's interact with Ig-alpha and Ig-beta sheath molecules...
  43. Vascular Remodeling in Transplant Arteriosclerosis
    Christiane Ferran; Fiscal Year: 2009
    ..We have shown that A20 is part of the regulatory cytoprotective response of EC to injury...
  44. A new approach to xenotransplantation in primate
    Juan Contreras; Fiscal Year: 2005
    ..Expression in the graft of anti-apoptotic or "protective genes", such as Bcl-2, A20 BcI-xL and heme oxygenase-1 (HO-1), make the graft resistant to rejection...
  45. Gene transfer with A20 to improve islet transplantation
    Christiane Ferran; Fiscal Year: 2003
    ..Our preliminary data reveals that A20 is part of the physiological response of islets to injury...
  46. Urine mRNA Profiling for Renal Allograft Surveillance
    Manikkam Suthanthiran; Fiscal Year: 2006
    ..In addition to mRNAs listed under Specific Aim 1, we will measure level of expression of mRNA for Bcl-2, A20, hemeoxygenase-1 (HO1), Bax, and transforming growth factor-beta1 (TGF-beta1) in urinary cells and test the ..
  47. IMMUNE RESPONSE TO HIV-1 ENCODED ANTIGENS IN MICE
    Man Sun Sy; Fiscal Year: 1991
    ..We transfected the tatIII gene of HIV- l into a murine B cell lymphoma (A20), a murine antigen specific T cell hybridoma (7E2) and a murine monocyte tumor line (P388D1)...
  48. Biochemical Mechanism of Poxvirus Replication
    MICHAEL O DONNELL; Fiscal Year: 2009
    ..Among these are the E9 DNA polymerase, A20 polymerase accessory protein, and the D4 uracyl deglycosylase (UDG) polymerase accessory proteins...
  49. MODULATION OF ENDOTHELIAL CELL RESPONSES BY A20
    Christiane Ferran; Fiscal Year: 2001
    DESCRIPTION (Adapted from Investigator's Abstract): A20, a novel Zn-finger protein, was first described as a TNF-inducible early response gene cloned from human umbilical vein endothelial cells (HUVEC)...
  50. Feedback regulation of innate immune signaling at mucosal surfaces
    Derek Abbott; Fiscal Year: 2009
    ..We have found that a key anti-inflammatory protein, A20, is phosphorylated and activated by the central kinase in the NF-?B signaling pathway (IKK2)...
  51. CYTOKINE MODULATION OF ENDOTHELIAL GENE EXPRESSION
    Vishva Dixit; Fiscal Year: 1992
    ..Importantly, one of these (A20) contains seven zinc fingers which is characteristic of a certain class of transcriptional factors...
  52. Functional analysis of polymorphisms in the anti-inflammatory protein A20
    James Lodolce; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): A20 is an anti-inflammatory protein that is required for terminating responses upstream of NF-kB activation...
  53. Induction of allograft tolerance in non-human primates
    Anthony Monaco; Fiscal Year: 2006
    ..Aim 2 will use RT -PCR and immunohistochemistry to identify anti-apoptotic genes A20, HO-l and Eck and correlate their presence with tolerance...
  54. Cloning Negative Regulators of TNF Signaling
    Adrian Ting; Fiscal Year: 2005
    ..TNFR1 signaling to the apoptosis pathway can be shut down by the NF-kappaB pathway, focusing on that mediated by A20. In addition, one of our aims was to identify other novel genes that can inhibit TNF signaling to the apoptosis ..
  55. Organ Culture of Basal Cell Carcinoma
    James Elder; Fiscal Year: 2002
    ....
  56. Amphiregulin in Psoriatic Epidermal Hyperplasia
    JAMES TILFORD ELDER; Fiscal Year: 2010
    ..If successful, this research will have important public health consequences not only in psoriasis but also in a wide variety of dermatoses characterized by epidermal hyperplasia. ..
  57. Purinergic signaling in endothelial cells.
    Elzbieta Kaczmarek; Fiscal Year: 2005
    ..abstract_text> ..
  58. ACTIVATION OF IKB KINASE BY HTLV-I TAX
    Shao Cong Sun; Fiscal Year: 2003
    ..abstract_text> ..
  59. UVEITIS GENE-EXPRESSION PROFILING
    James Rosenbaum; Fiscal Year: 2008
    ..The creation of a gene expression data base for patients with uveitis has the potential to clarify the pathogenesis of disease, establish new diagnostic tools, and provide a means for predicting prognosis. ..
  60. Meta-analysis of GWAS data to identify novel rheumatoid arthritis risk loci
    Robert M Plenge; Fiscal Year: 2010
    ..In addition, genetics should provide insight into important steps of the disease pathway, allowing for the development of new therapies that target these pathways in at-risk individuals. ..
  61. Dissecting the HLA contribution to Rheumatoid Arthritis
    LINDSEY ANN CRISWELL; Fiscal Year: 2010
    ..Finally, due to the clinical and apparent genetic heterogeneity of RA, we will study specific RA phenotypes as secondary outcomes. ..
  62. 2007 Viruses & Cells Gordon Conference
    Diane Griffin; Fiscal Year: 2007
    ..abstract_text> ..
  63. CHEMOTACTIC FACTORS IN ANIMAL MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 2008
    ..We believe that these aims are novel, innovative, especially suited to the skills and achievements demonstrated by our laboratory, and highly relevant to clarifying the pathogenesis of anterior uveitis. ..
  64. Regulation of TLR Signals and IBD by A20
    David Boone; Fiscal Year: 2008
    ..We have previously demonstrated that A20 is essential for the termination of TNF-induced NF-kB and that A20-/- mice develop IBD...
  65. Cb1-b in T Cell Activation and Tolerance
    Yun Cai Liu; Fiscal Year: 2006
    ....
  66. Immune Regulation by A20
    Averil Ma; Fiscal Year: 2006
    ..the mechanisms by which TNF signals are regulated and how such processes affect inflammation, we are studying A20, a novel molecule thought to regulate cellular responses to TNF...
  67. Immune Responses During Measles Virus Infection
    Diane Griffin; Fiscal Year: 2007
    ..3. To determine the roles of different CD4 and CD8 T cell populations in production of cytokines at various times during measles and the effect of concurrent HIV infection on these roles. ..
  68. Mapping HIV/AIDS genes with haplotype-based strategies
    Robert Plenge; Fiscal Year: 2008
    ..These studies hope to identify novel genes that influence susceptibility to HIV/AIDS, thereby providing insight into HIV/AIDS pathogenesis and, ultimately, improving patient care. ..
  69. Endotoxin-induced Uveitis Revisited
    James T Rosenbaum; Fiscal Year: 2010
    ..Future studies can buil d on these observations to test anti-inflammtory molecules induced by endotoxin as these molecules are potentially useful in the treatment of uveitis and other inflammations. ..