14 3 3 protein beta alpha

Summary

Gene Symbol: 14 3 3 protein beta alpha
Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Alias: GW128, HEL-S-1, HS1, KCIP-1, YWHAA, 14-3-3 protein beta/alpha, 14-3-3 alpha, brain protein 14-3-3, beta isoform, epididymis secretory protein Li 1, protein 1054, protein kinase C inhibitor protein-1, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
Species: human

Top Publications

  1. ncbi Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein
    S H Zhang
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Biol Chem 272:27281-7. 1997
  2. ncbi 14-3-3beta protein associates with insulin receptor substrate 1 and decreases insulin-stimulated phosphatidylinositol 3'-kinase activity in 3T3L1 adipocytes
    A Kosaki
    Clinical Research Unit, Diabetes Center, Kyoto National Hospital, Fushimi ku, Kyoto 612, Japan
    J Biol Chem 273:940-4. 1998
  3. ncbi Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population
    Y Wang
    Department of Molecular Biology, Parke Davis Pharmaceutical Research, Ann Arbor, Michigan, USA
    Cell Growth Differ 11:211-9. 2000
  4. pmc 14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation
    P C van der Hoeven
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Biochem J 345:297-306. 2000
  5. ncbi JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage
    Kiyotsugu Yoshida
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    Nat Cell Biol 7:278-85. 2005
  6. doi FoxO transcription factors; Regulation by AKT and 14-3-3 proteins
    Guri Tzivion
    Cancer Institute and Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Biochim Biophys Acta 1813:1938-45. 2011
  7. ncbi Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3
    Vivek Bhalla
    Division of Nephrology, Department of Medicine, University of California San Francisco, San Francisco, CA 94143 0532, USA
    Mol Endocrinol 19:3073-84. 2005
  8. ncbi 14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity
    T Benzing
    Department of Medicine, University Hospital of Freiburg, Hugstetterstr 55, 79106 Freiburg, Germany
    J Biol Chem 275:28167-72. 2000
  9. ncbi The subcellular localization of the ChoRE-binding protein, encoded by the Williams-Beuren syndrome critical region gene 14, is regulated by 14-3-3
    Giuseppe Merla
    Department of Genetic Medicine and Development, University of Geneva Medical School, Switzerland
    Hum Mol Genet 13:1505-14. 2004
  10. pmc Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein
    Tilman Brummer
    Cancer Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    EMBO J 27:2305-16. 2008

Research Grants

  1. PHAGOCYTOSIS IN PULMONARY ALVEOLAR MACROPHAGES
    Raphael Clynes; Fiscal Year: 2009
  2. GENETIC ANALYSIS OF THE CHICKEN BETA-GLOBIN LOCUS
    Elliot Epner; Fiscal Year: 2004
  3. Role of HS1 in Actin Regulation During T Cell Activation
    Timothy Gomez; Fiscal Year: 2006
  4. Actin Assembly Regulation in Lytic Synapse Formation
    William Butler; Fiscal Year: 2009
  5. HS1 Function in Dendritic Cells
    Deborah A Klos Dehring; Fiscal Year: 2010
  6. Functional G Protein pathways in platelet activation
    Satya P Kunapuli; Fiscal Year: 2010
  7. HS1 Function in Dendritic Cells
    Janis K Burkhardt; Fiscal Year: 2011
  8. ROLAND E BARON; Fiscal Year: 2016
  9. Benjamin D Ortiz; Fiscal Year: 2014
  10. HAX-1: a Multifaceted Family of Apoptotic Regulators
    Aikaterini Kontrogianni-Konstantopoulos; Fiscal Year: 2012

Detail Information

Publications233 found, 100 shown here

  1. ncbi Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein
    S H Zhang
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Biol Chem 272:27281-7. 1997
    ..These results raise the possibility that 14-3-3beta may function as an adaptor molecule in the regulation of PTPH1 and may provide a link between serine/threonine and tyrosine phosphorylation-dependent signaling pathways...
  2. ncbi 14-3-3beta protein associates with insulin receptor substrate 1 and decreases insulin-stimulated phosphatidylinositol 3'-kinase activity in 3T3L1 adipocytes
    A Kosaki
    Clinical Research Unit, Diabetes Center, Kyoto National Hospital, Fushimi ku, Kyoto 612, Japan
    J Biol Chem 273:940-4. 1998
    ..The specific activity of the PI3K in the former was approximately half of that in the latter, suggesting that 14-3-3beta protein bound to IRS-1 inhibits insulin-stimulated lipid kinase activity of PI3K in 3T3L1 adipocytes...
  3. ncbi Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population
    Y Wang
    Department of Molecular Biology, Parke Davis Pharmaceutical Research, Ann Arbor, Michigan, USA
    Cell Growth Differ 11:211-9. 2000
    ..The finding reveals a novel mechanism by which 14-3-3 regulates G2-M arrest and suggests that the NH2-terminal domain of Wee1 contains a negative regulatory sequence that determines Wee1 stability...
  4. pmc 14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation
    P C van der Hoeven
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Biochem J 345:297-306. 2000
    ..We conclude that 14-3-3 facilitates coupling of PKC-zeta to Raf-1 in an isotype-specific and phosphorylation-dependent manner. We suggest that 14-3-3 is a transient mediator of Raf-1 phosphorylation and activation by PKC-zeta...
  5. ncbi JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage
    Kiyotsugu Yoshida
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    Nat Cell Biol 7:278-85. 2005
    ..These findings indicate that 14-3-3 proteins are pivotal regulators of intracellular c-Abl localization and of the apoptotic response to genotoxic stress...
  6. doi FoxO transcription factors; Regulation by AKT and 14-3-3 proteins
    Guri Tzivion
    Cancer Institute and Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Biochim Biophys Acta 1813:1938-45. 2011
    ..This article is part of a Special Issue entitled: PI3K-AKT-FoxO axis in cancer and aging...
  7. ncbi Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3
    Vivek Bhalla
    Division of Nephrology, Department of Medicine, University of California San Francisco, San Francisco, CA 94143 0532, USA
    Mol Endocrinol 19:3073-84. 2005
    ..These results demonstrate a novel, physiologically significant role for 14-3-3 proteins in modulating ubiquitin ligase-dependent pathways in the control of epithelial ion transport...
  8. ncbi 14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity
    T Benzing
    Department of Medicine, University Hospital of Freiburg, Hugstetterstr 55, 79106 Freiburg, Germany
    J Biol Chem 275:28167-72. 2000
    ..Collectively, these data indicate that phosphorylation-dependent binding of 14-3-3 may act as molecular switch that controls the GAP activity keeping a substantial fraction of RGS proteins in a dormant state...
  9. ncbi The subcellular localization of the ChoRE-binding protein, encoded by the Williams-Beuren syndrome critical region gene 14, is regulated by 14-3-3
    Giuseppe Merla
    Department of Genetic Medicine and Development, University of Geneva Medical School, Switzerland
    Hum Mol Genet 13:1505-14. 2004
    ..This translocation is contingent upon the ability to bind 14-3-3. Through this mechanism the 14-3-3 isotypes directly affect the WBSCR14:Mlx complexes, which activate the transcription of lipogenic genes...
  10. pmc Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein
    Tilman Brummer
    Cancer Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    EMBO J 27:2305-16. 2008
    ..This represents a novel regulatory mechanism with implications for diverse tyrosine kinase signalling systems...
  11. pmc HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy
    Yan Xu
    Dorrance H Hamilton Laboratories, Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Thomas Jefferson University, 1020 Locust Street, Suite 329, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 101:7070-5. 2004
    ..These analyses suggest molecular mechanisms for the induction of apoptosis relating to the exposure of viral and host cell factors and rationally designed approaches toward neuroprotection...
  12. ncbi Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1583, USA
    Ann N Y Acad Sci 1024:153-67. 2004
    ....
  13. pmc An analysis of CAF-1-interacting proteins reveals dynamic and direct interactions with the KU complex and 14-3-3 proteins
    Maarten Hoek
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Biol Chem 286:10876-87. 2011
    ..These results highlight that CAF-1 has prominent interactions with the DNA repair machinery but that the N terminus is dispensable for the role of CAF-1 in DNA replication- and repair-coupled chromatin assembly...
  14. pmc A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex
    Alanna L Eilers
    Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 84112 5550, USA
    Mol Cell Biol 22:8514-26. 2002
    ..Second, an extracellular signal(s) must overcome the cytoplasmic localization function imparted by CRM1 and 14-3-3 binding to the N terminus of MondoA...
  15. ncbi Interaction of 14-3-3 proteins with the insulin-like growth factor I receptor (IGFIR): evidence for a role of 14-3-3 proteins in IGFIR signaling
    Susan L Spence
    Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 312:1060-6. 2003
    ..These findings suggest that 14-3-3 proteins interact with the IGFIR in vivo and that this interaction may play a role in a transformation pathway signaled by the IGFIR...
  16. doi Identification of 14-3-3β in human gastric cancer cells and its potency as a diagnostic and prognostic biomarker
    Chien Wei Tseng
    Department of Life Science, Institute of Molecular and Cellular Biology, National Taiwan University, Taipei, Taiwan
    Proteomics 11:2423-39. 2011
    ..Overall, these results highlight the significance of 14-3-3β in gastric cancer cell progression and suggest that it has the potential to be used as a diagnostic and prognostic biomarker in gastric cancer...
  17. pmc 14-3-3 proteins associate with cdc25 phosphatases
    D S Conklin
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, NY 11724, USA
    Proc Natl Acad Sci U S A 92:7892-6. 1995
    ..Instead, 14-3-3 may facilitate the association of cdc25 with Raf-1 in vivo, participating in the linkage between mitogenic signaling and the cell cycle machinery...
  18. ncbi C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding
    C Y Peng
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell Growth Differ 9:197-208. 1998
    ..Taken together, these results suggest that one function of C-TAK1 may be to regulate the interactions between Cdc25C and 14-3-3 in vivo by phosphorylating Cdc25C on serine 216...
  19. ncbi Cell type-specific regulation of B-Raf kinase by cAMP and 14-3-3 proteins
    W Qiu
    Department of Medicine and Cancer Center, University of California, San Diego, La Jolla, California 92093 0652, USA
    J Biol Chem 275:31921-9. 2000
    ..Our data suggest that 14-3-3 bound to B-Raf protects the enzyme from protein kinase A-mediated inhibition; the amount of 14-3-3 associated with B-Raf may explain the tissue-specific effects of cAMP on B-Raf kinase activity...
  20. pmc RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domain
    Jiaxin Niu
    Department of Pharmacology, University of Illinois at Chicago College of Medicine, Chicago, IL 60612, U S A
    Biochem J 365:677-84. 2002
    ..This study describes a new level in the regulation of G-protein signalling, in which the inhibitors of G-proteins, RGS proteins, can themselves be regulated by phosphorylation and binding 14-3-3...
  21. ncbi Role of the 14-3-3 C-terminal loop in ligand interaction
    Amy B Truong
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Proteins 49:321-5. 2002
    ..Taken together, these data support a role for the C-terminal loop as a general inhibitor of 14-3-3/ligand interactions. This may provide a mechanism by which inappropriate associations with 14-3-3 are prevented...
  22. ncbi Protein kinase A phosphorylation of human phosphodiesterase 3B promotes 14-3-3 protein binding and inhibits phosphatase-catalyzed inactivation
    Daniel Palmer
    Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 282:9411-9. 2007
    ..Moreover, we propose that this mechanism may allow cells to distinguish between PKA- and PKB-activated HSPDE3B...
  23. pmc Endothelin-1 inhibits the epithelial Na+ channel through betaPix/14-3-3/Nedd4-2
    Tengis S Pavlov
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Am Soc Nephrol 21:833-43. 2010
    ..Taken together, these results suggest that the inhibitory effects of chronic ET-1 on ENaC result from betaPix interacting with the 14-3-3/Nedd4-2 pathway...
  24. ncbi The complexity of Raf-1 regulation
    D K Morrison
    Molecular Basis of Carcinogenesis Laboratory, ABL Basic Research Program, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    Curr Opin Cell Biol 9:174-9. 1997
    ..The picture clearly emerging is that Raf-1 activity can be regulated by multiple mechanisms...
  25. ncbi 14-3-3 Binding to Na+/H+ exchanger isoform-1 is associated with serum-dependent activation of Na+/H+ exchange
    S Lehoux
    Center for Cardiovascular Research and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 276:15794-800. 2001
    ..13 +/- 0.02 versus 0.48 +/- 0.06 mmol of H(+)/min/liter, p < 0.01). These data suggest that 14-3-3 binding to NHE1 participates in serum-stimulated exchanger activation, a new function for 14-3-3...
  26. ncbi 14-3-3beta binds to big mitogen-activated protein kinase 1 (BMK1/ERK5) and regulates BMK1 function
    Qinlei Zheng
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Aab Institute of Biomedical Sciences, Rochester, New York 14642, USA
    J Biol Chem 279:8787-91. 2004
    ..These data demonstrate an inhibitory function for 14-3-3beta binding to BMK1 and show that serine 486 phosphorylation represents a novel regulatory mechanism for BMK1...
  27. pmc Vpr protein of human immunodeficiency virus type 1 binds to 14-3-3 proteins and facilitates complex formation with Cdc25C: implications for cell cycle arrest
    Tomoshige Kino
    Human Retrovirus Section, Center for Cancer Research, National Cancer Institute Frederick, Bldg 535, Rm 210, Frederick, MD 21702 1201, USA
    J Virol 79:2780-7. 2005
    ..These results indicate that Vpr promotes cell cycle arrest at the G(2)/M phase by facilitating association of 14-3-3 and Cdc25C independently of the latter's phosphorylation status...
  28. ncbi New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium
    Venice Calinisan
    Life Sciences Division, Department of Genome Biology, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Front Biosci 11:1646-66. 2006
    ..We also discuss the functional relevance of another member of the protein 4.1 superfamily, ezrin, in kidney physio-pathology...
  29. ncbi Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3
    Neil MacDonald
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, SK10 4TJ, United Kingdom
    Mol Cell 20:199-211. 2005
    ..14-3-3 isoforms thus represent a class of proteins that mediate the effect of histone phosphorylation at inducible genes...
  30. ncbi 14-3-3 alpha and delta are the phosphorylated forms of raf-activating 14-3-3 beta and zeta. In vivo stoichiometric phosphorylation in brain at a Ser-Pro-Glu-Lys MOTIF
    A Aitken
    Laboratory of Protein Structure, National Institute for Medical Research, Mill Hill, London, United Kingdom
    J Biol Chem 270:5706-9. 1995
    ....
  31. pmc Characterization of 14-3-3 proteins in adrenal chromaffin cells and demonstration of isoform-specific phospholipid binding
    D Roth
    Physiological Laboratory, University of Liverpool, U K
    Biochem J 301:305-10. 1994
    ..The Xenopus proteins lacks part of the extreme N-terminus, indicating that this domain is not essential for function in exocytosis...
  32. ncbi Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11
    S Y Hsu
    Department of Gynecology and Obstetrics, Stanford University Medical School, California 94305 5317, USA
    Mol Endocrinol 11:1858-67. 1997
    ....
  33. pmc Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins
    N O Ku
    VA Palo Alto Health Care System, 3801 Miranda Avenue, 154J, Palo Alto, CA 94304, USA
    EMBO J 17:1892-906. 1998
    ..Physiological Ser52 or Ser33 phosphorylation on distinct K18 molecules suggests functional compartmentalization of these modifications...
  34. ncbi A novel sphingosine-dependent protein kinase (SDK1) specifically phosphorylates certain isoforms of 14-3-3 protein
    T Megidish
    Pacific Northwest Research Institute, Seattle, Washington 98122 and Department of Pathobiology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 273:21834-45. 1998
    ....
  35. ncbi The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family
    C Dorner
    Medical Clinic IV, University of Tubingen, Tubingen, 72076 Germany
    J Biol Chem 274:33654-60. 1999
    ..Our data thus suggest that KIF1C can form dimers and is associated with proteins of the 14-3-3 family...
  36. ncbi 14-3-3zeta is an effector of tau protein phosphorylation
    M Hashiguchi
    Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    J Biol Chem 275:25247-54. 2000
    ..Our data suggest that 14-3-3zeta is a tau protein effector and may be involved in the abnormal tau phosphorylation occurring during Alzheimer's disease ontogeny...
  37. ncbi Identification of a novel interaction between integrin beta1 and 14-3-3beta
    D C Han
    Cancer Biology Laboratories, Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, New York, NY 14853, USA
    Oncogene 20:346-57. 2001
    ..Taken together, these results identify an interaction between integrin and 14-3-3 proteins and suggest a potentially novel cellular function for 14-3-3 proteins in the regulation of integrin-mediated cell adhesion and signaling events...
  38. pmc The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins
    Ying Wang
    Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, California 90095, USA
    Mol Cell Biol 22:916-26. 2002
    ..These data suggest that the normal localization and function of RIN1, as well as its ability to compete with RAF, are regulated in part by 14-3-3 binding, which in turn is controlled by PKD phosphorylation...
  39. ncbi Identification and characterization of the interaction between tuberin and 14-3-3zeta
    Mark Nellist
    Department of Clinical Genetics, Erasmus Medisch Centrum, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    J Biol Chem 277:39417-24. 2002
    ..Finally, it was shown that the tuberin/14-3-3zeta interaction is regulated by Akt-mediated phosphorylation of tuberin, providing insight into how tuberin may regulate phosphorylation of S6...
  40. ncbi Identification of the insulin-regulated interaction of phosphodiesterase 3B with 14-3-3 beta protein
    Hiroshi Onuma
    Department of Laboratory Medicine, Ehime University School of Medicine, Shigenobu, Ehime 791 0295, Japan
    Diabetes 51:3362-7. 2002
    ..Because insulin receptor substrate-1 also associates with 14-3-3, the dimeric 14-3-3 beta could function as a scaffolding protein in the activation of PDE3B by insulin...
  41. ncbi 14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity
    Megan E Cavet
    Center for Cardiovascular Research and Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 278:18376-83. 2003
    ..These data suggest that 14-3-3beta binding negatively regulates RSK1 activity to maintain signal specificity and that association/dissociation of the 14-3-3beta-RSK1 complex is likely to be important for mitogen-mediated RSK1 activation...
  42. ncbi Immunoexpression of 14-3-3 proteins in glial cytoplasmic inclusions of multiple system atrophy
    Takashi Komori
    Department of Clinical Neuropathology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu City, 183 8526 Tokyo, Japan
    Acta Neuropathol 106:66-70. 2003
    ..Our study suggests that 14-3-3 proteins are closely associated with alpha-synuclein in GCIs and 14-3-3 proteins may be candidate cofactors of alpha-synuclein in GCI formation...
  43. ncbi The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration
    Massimo M Santoro
    Department of Medical Sciences, University of Piemonte Orientale A Avogadro, 28100, Novara, Italy
    Dev Cell 5:257-71. 2003
    ....
  44. ncbi Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins
    Rose Boutros
    Molecular Oncology Laboratory, Oncology Research Unit, The Children s Hospital at Westmead, Locked Bag 4001, Westmead, NSW, 2145, Australia
    J Mol Biol 332:675-87. 2003
    ..These results identify 14-3-3 proteins as partners for hD53, and alternative splicing as a mechanism for regulating 14-3-3 binding...
  45. pmc 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1)
    Toshihiro Sekimoto
    Department of Cell Biology and Neuroscience, Graduate School of Medicine, Osaka University, Yamada oka, Suita, Osaka, Japan
    EMBO J 23:1934-42. 2004
    ..These findings indicate that 14-3-3 suppresses importin alpha/beta-dependent nuclear localization of Thr157-phosphorylated p27, suggesting implications for cell cycle disorder in Akt-activated cancer cells...
  46. ncbi 14-3-3 regulation of cell spreading and migration requires a functional amphipathic groove
    Luis G Rodriguez
    Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    J Cell Physiol 202:285-94. 2005
    ....
  47. ncbi Altered expression of 14-3-3 genes in the prefrontal cortex of subjects with schizophrenia
    Frank A Middleton
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 30:974-83. 2005
    ....
  48. pmc Convergent actions of I kappa B kinase beta and protein kinase C delta modulate mRNA stability through phosphorylation of 14-3-3 beta complexed with tristetraprolin
    Sonja I Gringhuis
    Department of Molecular Cell Biology and Immunology, VU Medical Center, P O Box 7057, 1007 MC Amsterdam, The Netherlands
    Mol Cell Biol 25:6454-63. 2005
    ..Thus, a key mechanism regulating mRNA binding and function of the destabilizing AUBP TTP involves the phosphorylation status of 14-3-3beta...
  49. pmc Subcellular targeting of p33ING1b by phosphorylation-dependent 14-3-3 binding regulates p21WAF1 expression
    Wei Gong
    Southern Alberta Cancer Research Institute, Dept of Biochemistry, University of Calgary, 370 Heritage Medical Research Building, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Mol Cell Biol 26:2947-54. 2006
    ..These data support the idea that the 14-3-3 proteins play a crucial role in regulating the activity of p33(ING1b) by directing its subcellular localization...
  50. ncbi Inhibitory interaction of the plasma membrane Na+/Ca2+ exchangers with the 14-3-3 proteins
    Maria V Pulina
    Venetian Institute of Molecular Medicine, and Department of Biochemistry, University of Padova, 35100 Padova, Italy
    J Biol Chem 281:19645-54. 2006
    ..In vitro binding experiments revealed that all three NCX isoforms interacted with multiple 14-3-3 isoforms. 14-3-3 was bound by both phosphorylated and nonphosphorylated NCX, but the phosphorylated form had much higher binding affinity...
  51. ncbi HIV-1 Vpr induces G2 cell cycle arrest in fission yeast associated with Rad24/14-3-3-dependent, Chk1/Cds1-independent Wee1 upregulation
    Naoto Matsuda
    Department of Microbiology, Dokkyo Medical University School of Medicine, Kita kobayashi 880, Mibu, Tochigi 321 0293, Japan
    Microbes Infect 8:2736-44. 2006
    ..The results may provide useful insights into the mechanism by which HIV-1 Vpr causes the G2 arrest in eukaryotic cells. Vpr may also serve as a useful molecular tool for exploring novel cell cycle control mechanisms...
  52. pmc DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 binding
    Monica Alvarez
    Genes and Disease Program, Centre de Regulacio Genomica, Parc de Recerca Biomedica de Barcelona, 08003 Barcelona, Spain
    Mol Biol Cell 18:1167-78. 2007
    ..These findings provide evidence for a novel mechanism for the regulation of DYRK1A kinase activity...
  53. ncbi Papillomavirus binding factor (PBF)-mediated inhibition of cell growth is regulated by 14-3-3beta
    Nadine Sichtig
    Institute of Virology, University of Cologne, Fürst Pückler Strasse 56, 50935 Cologne, Germany
    Arch Biochem Biophys 464:90-9. 2007
    ..Thus, our experiments characterized PBF as a new cellular factor mediating the effects of PI3K/Akt signaling and 14-3-3 on cell growth...
  54. ncbi Homodimerization of Ror2 tyrosine kinase receptor induces 14-3-3(beta) phosphorylation and promotes osteoblast differentiation and bone formation
    Yan Liu
    Women s Health and Musculoskeletal Biology, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    Mol Endocrinol 21:3050-61. 2007
    ..Our research forms a foundation for several new areas of investigation, including the molecular regulation of 14-3-3 by tyrosine phosphorylation and the role of this scaffold in osteogenesis...
  55. doi Isoform-specific cleavage of 14-3-3 proteins in apoptotic JURL-MK1 cells
    Katerina Kuzelova
    Department of Cellular Biochemistry, Institute of Hematology and Blood Transfusion, Prague 2, Czech Republic
    J Cell Biochem 106:673-81. 2009
    ..We suggest that the processing of 14-3-3 proteins could form an integral part of the programmed cell death or at least of some apoptotic pathways...
  56. doi Cytosolic RNA recognition pathway activates 14-3-3 protein mediated signaling and caspase-dependent disruption of cytokeratin network in human keratinocytes
    Tiina Ohman
    Protein Chemistry Research Group, Institute of Biotechnology, University of Helsinki, Finland
    J Proteome Res 9:1549-64. 2010
    ..In addition, we show that viral infection activates 14-3-3 protein mediated signaling pathways in human keratinocytes which suggest an important role of 14-3-3 proteins in antiviral innate immune response...
  57. ncbi The structural basis for 14-3-3:phosphopeptide binding specificity
    M B Yaffe
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Cell 91:961-71. 1997
    ..Finally, we show that the 14-3-3 dimer binds tightly to single molecules containing tandem repeats of phosphoserine motifs, implicating bidentate association as a signaling mechanism with molecules such as Raf, BAD, and Cbl...
  58. ncbi alpha-Synuclein shares physical and functional homology with 14-3-3 proteins
    N Ostrerova
    Department of Pharmacology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    J Neurosci 19:5782-91. 1999
    ..The activity and binding profile of alpha-synuclein suggests that it might act as a protein chaperone and that accumulation of alpha-synuclein could contribute to cell death in neurodegenerative diseases...
  59. pmc Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization
    C M Grozinger
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 97:7835-40. 2000
    ..Regulation of the cellular localization of HDAC4 and HDAC5 by 14-3-3 represents a mechanism for controlling the transcriptional activity of these class II HDAC proteins...
  60. pmc Regulation of histone deacetylase 4 by binding of 14-3-3 proteins
    A H Wang
    Molecular Oncology Group, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada
    Mol Cell Biol 20:6904-12. 2000
    ..These results indicate that 14-3-3 proteins negatively regulate HDAC4 by preventing its nuclear localization and thereby uncover a novel regulatory mechanism for HDACs...
  61. ncbi Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1
    J Y Toshima
    Department of Biomolecular Sciences, Graduate School of Life Sciences, Tohoku University, Sendai 980 8578, Japan
    J Biol Chem 276:43471-81. 2001
    ..We propose that 14-3-3beta plays important roles in regulating the kinase activity of TESK1 and localizing TESK1 to cell adhesion sites following integrin stimulation...
  62. ncbi Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms
    Barbra A Johnson
    Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:18029-36. 2002
    ..They also suggest that 14-3-3 binding is part of a complex network of stimuli and interactions that regulate TTP function...
  63. ncbi Regulation of TSC2 by 14-3-3 binding
    Yong Li
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 277:44593-6. 2002
    ..Phosphorylation of Ser(1210) in TSC2 is required for its association with 14-3-3. Our data indicate that 14-3-3 association may inhibit the function of TSC2 and represents a possible mechanism of TSC2 regulation...
  64. pmc Interaction with 14-3-3 proteins promotes functional expression of the potassium channels TASK-1 and TASK-3
    Sindhu Rajan
    Institute of Physiology, Marburg University, Deutschhausstrasse 2, 35037 Marburg, Germany
    J Physiol 545:13-26. 2002
    ..Our findings suggest that interaction of 14-3-3 with TASK-1 or TASK-3 may promote the trafficking of the channels to the surface membrane...
  65. ncbi Mammalian and yeast 14-3-3 isoforms form distinct patterns of dimers in vivo
    Maliha Chaudhri
    National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Biochem Biophys Res Commun 300:679-85. 2003
    ..The epsilon isoform formed heterodimers with 14-3-3 beta, gamma, zeta, and eta, but no homodimers were detected. The two 14-3-3 homologues, BMH1 and BMH2 from Saccharomyces cerevisiae, were mainly heterodimers...
  66. ncbi The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3
    Yong Li
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109, USA
    J Biol Chem 278:13663-71. 2003
    ..Phosphorylation of TSC2 by MK2 creates a 14-3-3 binding site and thus regulates the cellular function of the TSC2 tumor suppressor protein...
  67. ncbi MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding
    Carol A Chrestensen
    Department of Pharmacology, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Biol Chem 279:10176-84. 2004
    ..Thus, Ser(52) and Ser(178) are putative MK2 sites in vivo. Identified phosphosite(s) may be biologic switches controlling mRNA stability and translation...
  68. pmc A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia
    Kyoko Nagata-Ohashi
    Dept of Biomolecular Sciences, Graduate School of Life Sciences, Tohoku University, Aoba ku, Sendai, Miyagi 980 8578, Japan
    J Cell Biol 165:465-71. 2004
    ....
  69. pmc Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning
    Sheng Li Cai
    Department of Carcinogenesis, University of Texas MD Anderson Cancer Center, Smithville, 78957, USA
    J Cell Biol 173:279-89. 2006
    ..Thus, tuberin bound by 14-3-3 in response to AKT phosphorylation is sequestered away from its membrane-bound activation partner (hamartin) and its target GTPase (Rheb) to relieve the growth inhibitory effects of this tumor suppressor...
  70. doi A novel binding factor of 14-3-3beta functions as a transcriptional repressor and promotes anchorage-independent growth, tumorigenicity, and metastasis
    Yuko Komiya
    Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Yamazaki 2641, Noda shi, Chiba 278 8510, Japan
    J Biol Chem 283:18753-64. 2008
    ..These results indicate that FBI1 promotes sustained ERK1/2 activation through repression of MKP-1 transcription, resulting in promotion of tumorigenicity and metastasis...
  71. doi The expression of seven 14-3-3 isoforms in human meningioma
    Yang Liu
    Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi an, 710032, China
    Brain Res 1336:98-102. 2010
    ..In conclusion, The 14-3-3 epsilon, zeta and theta may be involved in tumorigenesis of meningioma and be efficient markers for predicting the degree of malignancy in meningioma...
  72. ncbi Assignment of the human genes encoding 14,3-3 Eta (YWHAH) to 22q12, 14-3-3 zeta (YWHAZ) to 2p25.1-p25.2, and 14-3-3 beta (YWHAB) to 20q13.1 by in situ hybridization
    N Tommerup
    Danish Center for Human Genome Research, John F Kennedy Institute, Glostrup, Denmark
    Genomics 33:149-50. 1996
  73. pmc Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1
    H Aoki
    Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    J Virol 74:1736-41. 2000
    ..These results suggest that HCV core protein may represent a novel type of Raf-1 kinase-activating protein through its interaction with 14-3-3 protein and may contribute to hepatocyte growth regulation...
  74. ncbi Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals
    Ita O'Kelly
    Yale University School of Medicine, Department of Pediatrics, Department of Cellular and Molecular Physiology, Boyer Center for Molecular Medicine, New Haven, CT 06536, USA
    Cell 111:577-88. 2002
    ..Other retained proteins are demonstrated to carry functional 14-3-3beta release motifs...
  75. ncbi 14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s)
    Matt Y Liu
    Department of Carcinogenesis, Science Park Research Division, The University of Texas M D Anderson Cancer Center, Smithville, Texas 78957, USA
    Cancer Res 62:6475-80. 2002
    ..Tuberin also coimmunoprecipitated with 14-3-3, confirming the interaction between endogenous 14-3-3 and tuberin. These data establish the presence of functional and overlapping 14-3-3 and Akt recognition site(s) in tuberin...
  76. pmc Protein phosphatase 1 binds to phospho-Ser-1394 of the macrophage-stimulating protein receptor
    Massimo M Santoro
    Department of Medical Sciences, University of Piemonte Orientale A Avogadro, Novara, Italy
    Biochem J 376:587-94. 2003
    ..These results suggest that PP1 can modulate the downstream Ron signalling generated by MSP via Akt/PKB and 14-3-3 binding. This is the first report on ligand-regulated association of PP1 with a growth factor receptor...
  77. ncbi Computational and experimental studies on human misshapen/NIK-related kinase MINK-1
    Kunbin Qu
    Rigel, Inc, 1180 Veterans Boulevard, South San Francisco, CA 94080, USA
    Curr Med Chem 11:569-82. 2004
    ..Further medicinal chemistry compound structure optimization and kinase assays are underway...
  78. ncbi Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1
    Tomoshige Kino
    Human Retrovirus Section, Center for Basic Research, National Cancer Institute Frederick, Frederick, Maryland 21702 1201, USA
    DNA Cell Biol 23:193-205. 2004
    ..Further studies on Vpr function are needed to fully assess the function of this important early regulatory molecule of HIV and other lentiviruses...
  79. pmc The 4.1/ezrin/radixin/moesin domain of the DAL-1/Protein 4.1B tumour suppressor interacts with 14-3-3 proteins
    Tingxi Yu
    David and Doreen Hermelin Laboratory of Molecular Oncogenetics, Department of Neurosurgery and Hermelin Brain Tumor Center, Henry Ford Hospital, E and R Bldg Rm 3096, 2799 W Grand Blvd Detroit, MI 48202, U S A
    Biochem J 365:783-9. 2002
    ..1/ezrin/radixin/moesin domain. The identification of this novel DAL-1/Protein 4.1B-interacting protein represents the first step towards elucidating its potentially unique mechanism of action...
  80. pmc An evolutionarily conserved family of virion tail needles related to bacteriophage P22 gp26: correlation between structural stability and length of the alpha-helical trimeric coiled coil
    Anshul Bhardwaj
    Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, 750 E Adams Street, Syracuse, NY 13210, USA
    J Mol Biol 391:227-45. 2009
    ..this idea experimentally and to explore their diversity, we cloned the gp26-like gene from phages HK620, Sf6 and HS1, and characterized these gene products in solution...
  81. ncbi A comparative study of the phosphotyrosyl phosphatase specificity of protein phosphatase type 2A and phosphotyrosyl phosphatase type 1B using phosphopeptides and the phosphoproteins p50/HS1, c-Fgr and Lyn
    P Agostinis
    Afdeling Biochemie, Faculteit der Geneeskunde, Katholieke Universiteit Leuven, Belgium
    Eur J Biochem 236:548-57. 1996
    ..examined in vitro using phosphotyrosine-containing peptides, derived from the phosphorylation sites of p34cdc2, p50/HS1 protein, Abl, c-Src and c-Fgr, as well as the intact phosphoprotein p50/HS1 and the Src-related tyrosine kinases, ..
  82. pmc Population structure of the relapsing fever spirochete Borrelia hermsii as indicated by polymorphism of two multigene families that encode immunogenic outer surface lipoproteins
    B J Hinnebusch
    Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 66:432-40. 1998
    ..The type strain, B. hermsii HS1, has at least 40 complete genes and pseudogenes that participate in this multiphasic antigenic variation...
  83. ncbi HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells
    E Ingley
    Laboratory for Cancer Medicine, Department of Biochemistry, The University of Western Australia and Royal Perth Hospital, WA 6001, Western Australia, Australia
    J Biol Chem 275:7887-93. 2000
    ..Here we show that the hemopoietic-specific protein HS1 interacted directly with the SH3 domain of Lyn, via its proline-rich region...
  84. ncbi Prevalence, numbers, and subtypes of Campylobacter jejuni and Campylobacter coli in uncooked retail meat samples
    Teck Lok Wong
    Food Safety Programme, Christchurch Science Centre, Institute of Environmental Science and Research, P O Box 29 181, Christchurch, New Zealand
    J Food Prot 70:566-73. 2007
    ..Seven Penner serotypes (HS1 complex, 2, 4 complex, 6, 11, 27, and 42) were represented by 10 or more isolates from chicken...
  85. ncbi Metabolites of hirsuteine and hirsutine, the major indole alkaloids of Uncaria rhynchophylla, in rats
    Takahiro Nakazawa
    Department of Natural Products Chemistry, Tohoku Pharmaceutical University, Japan
    Biol Pharm Bull 29:1671-7. 2006
    ..Similarly HS also was metabolized to two compounds (HS1 and HS2)...
  86. doi Isolation and characterization of Helicobacter suis sp. nov. from pig stomachs
    M Baele
    Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Int J Syst Evol Microbiol 58:1350-8. 2008
    ..Three isolates, HS1(T), HS2 and HS3, were subcultured from the stomach mucosa of three pigs after slaughter and were analysed using a ..
  87. doi Expression of BvGLP-1 encoding a germin-like protein from sugar beet in Arabidopsis thaliana leads to resistance against phytopathogenic fungi
    Katrin Knecht
    Department of Molecular Phytopathology, Institute of Phytopathology Chrstian Albrechts University of Kiel, Hermann Rodewald Str 9, Kiel, Germany
    Mol Plant Microbe Interact 23:446-57. 2010
    ..Heterodera schachtii) resistance in sugar beet (Beta vulgaris) is controlled by a single dominant resistance gene, Hs1(pro-1). BvGLP-1 was cloned from resistant sugar beet...
  88. pmc The HoxC4 homeodomain protein mediates activation of the immunoglobulin heavy chain 3' hs1,2 enhancer in human B cells. Relevance to class switch DNA recombination
    Edmund C Kim
    Center for Immunology, College of Medicine and School of Biological Sciences, University of California, Irvine, California 92697 4120, USA
    J Biol Chem 279:42258-69. 2004
    ..CSR and SHM are central to the maturation of the antibody response. In contrast to the single 5'-hs3a-hs1,2-hs3b-hs4-3 ' mouse IgH 3 ' regulatory region, the human IgH 3 ' regulatory region exists as a 5'-hs3-hs1,2-hs4-3' ..
  89. pmc Antigen-receptor induced clonal expansion and deletion of lymphocytes are impaired in mice lacking HS1 protein, a substrate of the antigen-receptor-coupled tyrosine kinases
    I Taniuchi
    Department of Molecular Immunology, Kyushu University, Fukuoka, Japan
    EMBO J 14:3664-78. 1995
    b>HS1, an intracellular protein expressed specifically in hematopoietic cells, is rapidly tyrosine phosphorylated after cross-linking of antigen receptors on B and T lymphocytes, implicating involvement of this molecule in the signal ..
  90. ncbi Temporal expression of a V(H) promoter-Cmu transgene linked to the IgH HS1,2 enhancer
    T Andersson
    Center for Genomics Research, Karolinska Institutet, Stockholm, Sweden
    Mol Immunol 36:19-29. 1999
    ..One of these cis-acting elements is the IgH HS1,2 enhancer and previous studies in transgenic mice have revealed a temporally restricted activity of an HS1,2 ..
  91. ncbi Syk-mediated tyrosine phosphorylation is required for the association of hematopoietic lineage cell-specific protein 1 with lipid rafts and B cell antigen receptor signalosome complex
    Jian Jiang Hao
    Departments of Experimental Pathology and Immunology, Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA
    J Biol Chem 279:33413-20. 2004
    Hematopoietic lineage cell-specific protein 1 (HS1) is an F-actin- and actin-related proteins 2 and 3 (Arp2/3)-binding protein that undergoes a rapid tyrosine phosphorylation upon B cell antigen receptor (BCR) activation...
  92. ncbi HS1-BP3 gene variant is common in familial essential tremor
    Joseph J Higgins
    Center for Human Genetics and Child Neurology, Mid Hudson Family Health Institute, New Paltz, New York, USA
    Mov Disord 21:306-9. 2006
    ..A variant (828C-->G) in exon 7 of the hematopoietic-specific protein 1 binding protein 3 gene (HS1-BP3) on chromosome 2p recently has been found to segregate with ET in 2 families...
  93. ncbi Evaluation of the role of the 3'alpha heavy chain enhancer [3'alpha E(hs1,2)] in Vh gene somatic hypermutation
    K M Tumas Brundage
    Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson Medical College, Philadelphia, PA 19107
    Mol Immunol 34:367-78. 1997
    ..To examine whether the 3'alpha heavy chain enhancer [3'alpha E(hs1,2)] is required for somatic hypermutation of VH genes, we generated two types of transgenic mice...
  94. ncbi A family with Parkinson disease, essential tremor, bell palsy, and parkin mutations
    Hao Deng
    Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Arch Neurol 64:421-4. 2007
    Mutations in the parkin gene cause autosomal recessive early-onset Parkinson disease (EOPD). The A265G variant in the HS1 binding protein 3 gene (HS1BP3) is common in essential tremor (ET).
  95. pmc Polymorphism of immunoglobulin enhancer element HS1,2A: allele *2 associates with systemic sclerosis. Comparison with HLA-DR and DQ allele frequency
    D Frezza
    Department of Biology Enrico Calef, University of Tor Vergata, Rome, Italy
    Ann Rheum Dis 66:1210-5. 2007
    To investigate the relationship of the polymorphic enhancer HS1,2 central to the 3' enhancer complex regulatory region (IgH3'EC) of the immunoglobulin heavy chain genes with systemic sclerosis (SSc) disease and compare it with HLA-DR and ..
  96. doi Molecular analysis of gamma-globin promoters, HS-111 and 3'HS1, in beta-thalassemia intermedia patients associated with high levels of Hb F
    Mohammad Hamid
    Department of Clinical Genetics, National Institute of Genetic Engineering and Biotechnology NIGEB, Tehran, Iran
    Hemoglobin 33:428-38. 2009
    The nucleotide (nt) variations in the promoter region of the gamma-globin genes, HS-111 and 3'HS1 regions, were studied in Iranian patients with beta-thalassemia intermedia (beta-TI), beta-thalassemia major (beta-TM) and healthy ..
  97. pmc DNase I hypersensitivity and epsilon-globin transcriptional enhancement are separable in locus control region (LCR) HS1 mutant human beta-globin YAC transgenic mice
    Motoshi Shimotsuma
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan
    J Biol Chem 285:14495-503. 2010
    ..locus depends on enhancement by the locus control region, which consists of five DNase I hypersensitive sites (5'HS1 through 5'HS5)...
  98. ncbi Pathophysiology of a sickle cell trait mouse model: human alpha(beta)(S) transgenes with one mouse beta-globin allele
    C T Noguchi
    Laboratory of Chemical Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 1822, USA
    Blood Cells Mol Dis 27:971-7. 2001
    ..The mice segregated into two subpopulations containing low and high proportions of hemoglobin S (m(beta)/hS1 and m(beta)/hS2, respectively) that was associated with one or two human h(alpha)beta(S) transgenes...
  99. ncbi Differential regulation of chromatin structure of the murine 3' IgH enhancer and IgG2b germline promoter in response to lipopolysaccharide and CD40 signaling
    Xincheng Qin
    The Center for Molecular Microbiology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China
    Mol Immunol 43:1211-20. 2006
    ..two essential subunits of murine SWI/SNF complex, differentially associate with the DNase I hypersensitive region HS1/2 of 3'E and the IgG2b germline promoter in response to LPS activation or CD40 engagement...
  100. pmc Transcription of a productively rearranged Ig VDJC alpha does not require the presence of HS4 in the IgH 3' regulatory region
    Buyi Zhang
    Department of Biological Sciences, Hunter College and Graduate Center of the City University of New York, New York, NY 10021, USA
    J Immunol 178:6297-306. 2007
    ..These include the intronic enhancer (Emu) and several elements at the 3' end of the locus (hs1,2, hs3a, hs3b, and hs4) known collectively as the 3' regulatory region...
  101. pmc Nucleosome and transcription activator antagonism at human beta-globin locus control region DNase I hypersensitive sites
    AeRi Kim
    Department of Molecular Biology, College of Natural Sciences, Pusan National University, Pusan 609 735, Korea
    Nucleic Acids Res 35:5831-8. 2007
    ..Nucleosomes were variably depleted at hypersensitive sites HS1-HS4 and at HS5 which flanks the 5' of the locus...

Research Grants28

  1. PHAGOCYTOSIS IN PULMONARY ALVEOLAR MACROPHAGES
    Raphael Clynes; Fiscal Year: 2009
    ..In Specific Aim II, we will determine whether Abpl and/or its family members, cortactin and HS1, coordinate the delivery of cytoskeletal components with endo-/exocytic machinery (dynamin)...
  2. GENETIC ANALYSIS OF THE CHICKEN BETA-GLOBIN LOCUS
    Elliot Epner; Fiscal Year: 2004
    ..2. The role of the upstream hypersensitive sites (HSS) (5'HS1-4) in the chicken beta-globin locus will be investigated including the insulator boundary region (5'HS4)...
  3. Role of HS1 in Actin Regulation During T Cell Activation
    Timothy Gomez; Fiscal Year: 2006
    ..This application focuses on the leukocyte-specific homologue of Cortactin, HS1, a multi-domain signaling molecule that binds actin and the Arp2/3 Complex...
  4. Actin Assembly Regulation in Lytic Synapse Formation
    William Butler; Fiscal Year: 2009
    ..Arp2/3 and formins are two distinct actin nucleators and HS1 is a known activator of Arp2/3, yet their roles in immune cell functions and in particular NK cells remains ..
  5. HS1 Function in Dendritic Cells
    Deborah A Klos Dehring; Fiscal Year: 2010
    ..One of these proteins is HS1, for which a function in DCs has not been investigated...
  6. Functional G Protein pathways in platelet activation
    Satya P Kunapuli; Fiscal Year: 2010
    ..Finally, we will evaluate the functional role of HS1 in platelets using mice-deficient in HS1 in ex vivo platelet functional studies and in vivo thrombosis models...
  7. HS1 Function in Dendritic Cells
    Janis K Burkhardt; Fiscal Year: 2011
    ..In T cells, we showed previously that WASp works together with another actin regulatory protein, HS1. HS1 is also expressed in dendritic cells, and our preliminary data show that HS1 is required for efficient antigen ..
  8. ROLAND E BARON; Fiscal Year: 2016
    ..2- Determine the role of cortactin (and its close homolog HS1) and its interaction with EB1 in the link between MTs and actin dynamics in podosomes...
  9. Benjamin D Ortiz; Fiscal Year: 2014
    ..A hurdle to achieving this goal is the lack of essential molecular knowledge of two key LCR elements (named HS1'and HS4)...
  10. HAX-1: a Multifaceted Family of Apoptotic Regulators
    Aikaterini Kontrogianni-Konstantopoulos; Fiscal Year: 2012
    HAX-1 was identified ~10 years ago as a binding partner of HS1, a protein involved in the maturation of T-cells...
  11. 3'alpha enhancer regulation by AhR and NF-kappaB/Rel proteins
    COURTNEY ELIZABETH WILLIAMS SULENTIC; Fiscal Year: 2011
    ..We have detected binding of AhR to ORE sites within two enhancers of the 3'lgH RR, hs1,2 and hs4, and find that these ORE sites are closely associated with NF-icB binding motifs...
  12. Yanping Huang; Fiscal Year: 2014
    ..the hypothesis that c-Abl regulates T cell activation by regulating the function of the actin-associated proteins HS1 and WAVE2...
  13. Gene therapy for Cooley's anemia in a new mouse model
    Stefano Rivella; Fiscal Year: 2010
    ..from TNS9 by extending the beta-globin promoter by 1 Kb and inserting a 1 Kb genomic region corresponding to the HS1 of the LCR...
  14. Daniel A Hammer; Fiscal Year: 2016
    ..gradients of single chemokines on multiple adhesive ligands;2) to measure the effects of regulatory proteins HS1 and WASp on DC migration in single chemokine gradients;and 3) to measure the forces of DC migration during turning ..
  15. Cytoskeletal control of Leishmania infection
    DAWN MARIE WETZEL; Fiscal Year: 2012
    ..These kinases are known to activate cortactin, which triggers actin-based cell edge protrusions. HS1 (hematopoietic lineage cell-specific protein 1) is a protein related to cortactin that is found in macrophages...
  16. ACTIN AND MICROTUBULE-BASED MECHANISMS FOR FUNCTIONS OF NK LYMPHOID CELLS
    John A Cooper; Fiscal Year: 2013
    ..In previous studies, we discovered that the cortactin homologue HS1 is essential for many actin-based functions and signaling pathways...
  17. A quantative understanding of the regulation of actin dynamics in live T cells
    Christoph Wuelfing; Fiscal Year: 2010
    ..we will investigate the Arp2/3 complex, its three activators WASP, WAVE2, and the hematopoietic cortactin homolog HS1, capping protein, the actin filament severing protein cofilin, and actin itself...
  18. Anna Huttenlocher; Fiscal Year: 2014
    ..cell polarization and directed cell migration in multicelluar environments In Aim 3, we propose to study how Hax1/HS1/G113 signaling modulates neutrophil motility and recruitment in more complex 3D and cell sourced gradients to mimic ..
  19. Locus control region function on inactive x-chromosomes
    JORG BUNGERT; Fiscal Year: 2003
    ..of five subregions that reveal strong sensitivity to deoxyribonuclease I in erythroid cells (hypersensitive sites HS1 to HS5)...
  20. Regulation of Distinc Actin Nucleation Mechanisms in Immune Cell Functions
    WILLIAM BOYD BUTLER; Fiscal Year: 2011
    ..Arp2/3 and formins are two distinct actin nucleators and HS1 is a known activator of Arp2/3, yet their roles in immune cell functions and in particular natural killer (NK) ..
  21. HIGHER SPEED, FIELD & SPATIAL RESOLUTION BRAIN 3D 1H MRS
    Oded Gonen; Fiscal Year: 2001
    ..of two non-echo, multivoxel 1H MRS techniques: Chemical Shift Imaging (CSl) with Hadamard Spectroscopic Imaging (HS1). Three significant benefits could be realized...
  22. Regulation of Distinc Actin Nucleation Mechanisms in Immune Cell Functions
    William Butler; Fiscal Year: 2009
    ..Arp2/3 and formins are two distinct actin nucleators and HS1 is a known activator of Arp2/3, yet their roles in immune cell functions and in particular natural killer (NK) ..
  23. The Role of HS1 in T Cell Activation
    Esteban Carrizosa; Fiscal Year: 2008
    ..Though the regulation of T cell actin responses are poorly understood, one key player is HS1, an actin regulatory protein with genetic links to Lupus...
  24. Normal and aberrant switch recombination to the murine alpha heavy chain gene
    Wesley Dunnick; Fiscal Year: 2008
    ..The information is also likely to be relevant to normal switch recombination, with implications for better vaccine design. [unreadable] [unreadable] [unreadable]..
  25. Quantitating chromatin dynamics during erythropoiesis
    M Bender; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  26. DNA SEQUENCES INVOLVED IN THE HEAVY CHAIN SWITCH
    Wesley Dunnick; Fiscal Year: 2006
    ..We will examine the role of the orientation of switch sequences, and hence the role of the unusual complexes between germline transcripts and switch region DNA, in Aim 4. ..
  27. Movement of Ezrin and CD43 During T Cell Signaling
    JANIS BURKHARDT; Fiscal Year: 2005
    ..Taken together, these studies will address the mechanism by which ezrin, CD43 and other proteins are removed from the T cell: APC contact site, and the consequences of this molecular rearrangement for T cell function. ..
  28. REGULATION OF MICROTUBLE BASED T CELL EFFECTOR FUNCTION
    JANIS BURKHARDT; Fiscal Year: 2003
    ..Since therapeutic strategies based upon stimulating these cells are currently in clinical trials, gaining a better understanding of these fundamental processes will be critical for their optimal clinical deployment. ..