wupA

Summary

Gene Symbol: wupA
Description: wings up A
Alias: CG7178, DROTROPONI, DmTpnI, Dmel\CG7178, HDP, HL-I, HL08042, HLI, Tn I, TnI, TpnI, WupA, chrX:17947374..17947524, fliH, hdp, hdp-a, hdp2, wup-A, CG7178 gene product from transcript CG7178-RD, CG7178-PA, CG7178-PB, CG7178-PC, CG7178-PD, CG7178-PE, CG7178-PF, CG7178-PG, CG7178-PH, CG7178-PI, CG7178-PJ, CG7178-PK, CG7178-PL, CG7178-PM, flightless H, flightless-H, haplo-lethal region I, held up, held-up, held-up2, heldup, heldup-a, troponin, troponin I, troponin-I, wings up, wings-up A, wupA-PA, wupA-PB, wupA-PC, wupA-PD, wupA-PE, wupA-PF, wupA-PG, wupA-PH, wupA-PI, wupA-PJ, wupA-PK, wupA-PL, wupA-PM
Species: fruit fly

Top Publications

  1. pmc Affecting Rhomboid-3 function causes a dilated heart in adult Drosophila
    Lin Yu
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS Genet 6:e1000969. 2010
  2. pmc Transcription of Drosophila troponin I gene is regulated by two conserved, functionally identical, synergistic elements
    María Cruz Marín
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002, Spain
    Mol Biol Cell 15:1185-96. 2004
  3. pmc Flightin is essential for thick filament assembly and sarcomere stability in Drosophila flight muscles
    M C Reedy
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Cell Biol 151:1483-500. 2000
  4. pmc Specific myosin heavy chain mutations suppress troponin I defects in Drosophila muscles
    W A Kronert
    Department of Biology and Molecular Biology Institute, San Diego State University, San Diego, California 92182 4614, USA
    J Cell Biol 144:989-1000. 1999
  5. ncbi Troponin I is required for myofibrillogenesis and sarcomere formation in Drosophila flight muscle
    Upendra Nongthomba
    Department of Biology, University of York, York, YO10 5DD, UK
    J Cell Sci 117:1795-805. 2004
  6. pmc Overexpression of troponin T in Drosophila muscles causes a decrease in the levels of thin-filament proteins
    Raquel Marco-Ferreres
    Departamento de Bioquímica and Instituto Investigaciones Biomédicas, UAM CSIC, Facultad de Medicina, Universidad Autonoma de Madrid, Arzobispo Morcillo 4, 28029 Madrid, Spain
    Biochem J 386:145-52. 2005
  7. ncbi Calcineurin function is required for myofilament formation and troponin I isoform transition in Drosophila indirect flight muscle
    Kathleen M Gajewski
    Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Dev Biol 289:17-29. 2006
  8. pmc Drosophila as a model for the identification of genes causing adult human heart disease
    Matthew J Wolf
    Department of Medicine, Duke University, Durham, NC 27110, USA
    Proc Natl Acad Sci U S A 103:1394-9. 2006
  9. pmc A method to measure myocardial calcium handling in adult Drosophila
    Na Lin
    Institute of Molecular Medicine, Peking University, Beijing, China
    Circ Res 108:1306-15. 2011
  10. pmc Myocyte enhancer factor 2 and chorion factor 2 collaborate in activation of the myogenic program in Drosophila
    Kathleen K Kelly Tanaka
    Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    Mol Cell Biol 28:1616-29. 2008

Patents

  1. ANTISENSE-OLIGONUCLEOTIDES FOR THE TREATMENT OF IMMUNOSUPPRESSIVE EFFECTS OF TRANSFORMING GROWTH FACTOR--g(b) (TGF--g(b))

Scientific Experts

  • Nallur B Ramachandra
  • Yanning Rui
  • Anton L Bryantsev
  • Michael A Choma
  • Uwe Irion
  • J O Vigoreaux
  • Robert A Schulz
  • C J Elliott
  • Kathleen M Gajewski
  • Abhay Sharma
  • Roberto Marco
  • Upendra Nongthomba
  • Matthew J Wolf
  • Lin Yu
  • Raul Herranz
  • John C Sparrow
  • Maria Sevdali
  • Elena García-Zaragoza
  • Margarita Cervera
  • Na Lin
  • Jesus Mateos
  • Howard A Rockman
  • A Ferrus
  • Anthony Cammarato
  • John Sparrow
  • Wee Choo Puah
  • Arunita Chatterjee
  • Meg Stark
  • Rekha Gautam
  • Hena Firdaus
  • Salam Herojeet Singh
  • Teresa E Lee
  • Sandy T Oas
  • Isabelle Fernandes
  • Ying Che Chang
  • Jose Antonio Mas
  • Dennis M Abraham
  • Richard M Cripps
  • Marieke J Bloemink
  • Sarah E Haigh
  • P G Vikhorev
  • J C Sparrow
  • Virender Kumar Sahota
  • Kathleen K Kelly Tanaka
  • T K Rajendra
  • Juan J Arredondo
  • Alberto Ferrús
  • A Prado
  • Maqsood Ansari
  • J A Barbas
  • Thien Phong Vu Manh
  • Raquel Marco-Ferreres
  • Roger Craig
  • William Lehman
  • María Cruz Marín
  • Enrico S Montana
  • Mark Cummins
  • I Canal
  • Debasish Roy
  • Esha Patnaik
  • Martin Wasser
  • Sarwat Naz
  • Sandeep Vanga
  • Aditi Madan
  • Jayaram Mohan
  • Narayanappa Gayathri
  • Siva Umapathy
  • Prabhashankar Arathi
  • Saraf R Ramesh
  • Frieder Schock
  • Prabodh Kumar
  • Suh Yuen Liang
  • Hong Wen Tang
  • Michelle Peckham
  • Tzu Ching Meng
  • Kay Hooi Khoo
  • Vikash Kumar
  • Guang Chao Chen
  • Tsung Hsien Pu
  • B Naimi
  • Nima Badie
  • Dennis Abraham
  • Nenad Bursac
  • Corey M Dambacher
  • Heping Cheng
  • Girish C Melkani
  • Michael A Geeves
  • Sanford I Bernstein
  • M Aguilera
  • M C Reedy

Detail Information

Publications67

  1. pmc Affecting Rhomboid-3 function causes a dilated heart in adult Drosophila
    Lin Yu
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS Genet 6:e1000969. 2010
    ....
  2. pmc Transcription of Drosophila troponin I gene is regulated by two conserved, functionally identical, synergistic elements
    María Cruz Marín
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002, Spain
    Mol Biol Cell 15:1185-96. 2004
    The Drosophila wings-up A gene encodes Troponin I. Two regions, located upstream of the transcription initiation site (upstream regulatory element) and in the first intron (intron regulatory element), regulate gene expression in specific ..
  3. pmc Flightin is essential for thick filament assembly and sarcomere stability in Drosophila flight muscles
    M C Reedy
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Cell Biol 151:1483-500. 2000
    ..Our results indicate that flightin is required for the establishment of normal thick filament length during late pupal development and thick filament stability in adult after initiation of contractile activity...
  4. pmc Specific myosin heavy chain mutations suppress troponin I defects in Drosophila muscles
    W A Kronert
    Department of Biology and Molecular Biology Institute, San Diego State University, San Diego, California 92182 4614, USA
    J Cell Biol 144:989-1000. 1999
    ..heavy chain prevent a degenerative muscle syndrome resulting from the hdp2 mutation in the thin filament protein troponin I. One mutation deletes eight residues from the actin binding loop of myosin, while a second affects a residue at ..
  5. ncbi Troponin I is required for myofibrillogenesis and sarcomere formation in Drosophila flight muscle
    Upendra Nongthomba
    Department of Biology, University of York, York, YO10 5DD, UK
    J Cell Sci 117:1795-805. 2004
    ..A troponin I (TnI) mutation, hdp(3), leads to an absence of TnI in the IFMs and tergal depressor of trochanter (TDT) muscles ..
  6. pmc Overexpression of troponin T in Drosophila muscles causes a decrease in the levels of thin-filament proteins
    Raquel Marco-Ferreres
    Departamento de Bioquímica and Instituto Investigaciones Biomédicas, UAM CSIC, Facultad de Medicina, Universidad Autonoma de Madrid, Arzobispo Morcillo 4, 28029 Madrid, Spain
    Biochem J 386:145-52. 2005
    ..decrease in the amount of this protein as well as that of other thin-filament proteins such as tropomyosin, troponin I and actin...
  7. ncbi Calcineurin function is required for myofilament formation and troponin I isoform transition in Drosophila indirect flight muscle
    Kathleen M Gajewski
    Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Dev Biol 289:17-29. 2006
    ..Calcineurin B2 also plays a role in the transition to an adult-specific isoform of troponin I during the late pupal stages, although the incompleteness of this transition in calcineurin B2 mutants does not ..
  8. pmc Drosophila as a model for the identification of genes causing adult human heart disease
    Matthew J Wolf
    Department of Medicine, Duke University, Durham, NC 27110, USA
    Proc Natl Acad Sci U S A 103:1394-9. 2006
    ..Drosophila have a fractional shortening of 87 +/- 4%, whereas cardiomyopathic flies that contain a mutation in troponin I or tropomyosin show severe impairment of systolic function...
  9. pmc A method to measure myocardial calcium handling in adult Drosophila
    Na Lin
    Institute of Molecular Medicine, Peking University, Beijing, China
    Circ Res 108:1306-15. 2011
    ..However, a genetically robust system for unbiased screens of mutations that affect Ca(2+) handling remains a challenge...
  10. pmc Myocyte enhancer factor 2 and chorion factor 2 collaborate in activation of the myogenic program in Drosophila
    Kathleen K Kelly Tanaka
    Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    Mol Cell Biol 28:1616-29. 2008
    ....
  11. ncbi Monitoring development and pathology of Drosophila indirect flight muscles using green fluorescent protein
    P Barthmaier
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Dev Biol 169:770-4. 1995
    ..GFP fluorescence can be used to visualize all stages of flight muscle development subsequent to myoblast fusion nad facilitates the detection of morphological changes in fibers caused by particular mutations...
  12. pmc Abnormal muscle development in the heldup3 mutant of Drosophila melanogaster is caused by a splicing defect affecting selected troponin I isoforms
    J A Barbas
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Mol Cell Biol 13:1433-9. 1993
    The troponin I (TnI) gene of Drosophila melanogaster encodes a family of 10 isoforms resulting from the differential splicing of 13 exons. Four of these exons (6a1, 6a2, 6b1, and 6b2) are mutually exclusive and very similar in sequence...
  13. doi CF2 activity and enhancer integration are required for proper muscle gene expression in Drosophila
    Elena García-Zaragoza
    Instituto Investigaciones Biomédicas Alberto Sols, Departamento de Bioquimica, Facultad de Medicina, UAM CSIC, Arzobispo Morcillo 4, 28029 Madrid, Spain
    Mech Dev 125:617-30. 2008
    ..However, it may also be a more general mechanism to control the correct levels of gene expression during development in each cell type...
  14. ncbi Mutations affecting the indirect flight muscles of Drosophila melanogaster
    I I Deak
    J Embryol Exp Morphol 69:61-81. 1982
    ..The absence of reduction of the 54 K protein was strongly correlated with aberrant Z-bands...
  15. pmc Functional interactions between unlinked muscle genes within haploinsufficient regions of the Drosophila genome
    T Homyk
    Department of Biology, University of Virginia, Charlottesville 22901
    Genetics 119:105-21. 1988
    ....
  16. doi In vitro motility of native thin filaments from Drosophila indirect flight muscles reveals that the held-up 2 TnI mutation affects calcium activation
    P G Vikhorev
    Department of Biology, University of York, York YO10 5DD, UK
    J Muscle Res Cell Motil 31:171-9. 2010
    ..Regulated native thin filaments from wild type and a troponin I mutant, held-up-2, were compared by in vitro motility assays that showed that the mutant troponin I caused ..
  17. pmc Muscle abnormalities in Drosophila melanogaster heldup mutants are caused by missing or aberrant troponin-I isoforms
    C J Beall
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218
    J Cell Biol 114:941-51. 1991
    ..We find that the heldup gene encodes troponin-I, one of the principal regulatory proteins associated with skeletal muscle thin filaments...
  18. ncbi Genetics of the Drosophila flight muscle myofibril: a window into the biology of complex systems
    J O Vigoreaux
    Department of Biology, University of Vermont, Burlington, VT 05405 USA
    Bioessays 23:1047-63. 2001
    ....
  19. pmc Suppression of muscle hypercontraction by mutations in the myosin heavy chain gene of Drosophila melanogaster
    Upendra Nongthomba
    Department of Biology, University of York, York YO10 5YW, United Kingdom
    Genetics 164:209-22. 2003
    ..Flight muscle contraction is regulated by both stretch and Ca(2+)-induced thin filament (actin + tropomyosin + troponin complex) activation...
  20. pmc Functional recovery of troponin I in a Drosophila heldup mutant after a second site mutation
    A Prado
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Mol Biol Cell 6:1433-41. 1995
    ..We have applied this system to the case of troponin I (TnI) in Drosophila and its mutant allele heldup2 (hdp2)...
  21. pmc Genetic analysis of the Shaker gene complex of Drosophila melanogaster
    A Ferrus
    Instituto Cajal, CSIC, Madrid, Spain
    Genetics 125:383-98. 1990
    ..We discuss the relationship between the genetic organization of ShC and the functional coupling of potassium currents with the other functions encoded in the complex...
  22. ncbi Troponin I is encoded in the haplolethal region of the Shaker gene complex of Drosophila
    J A Barbas
    Instituto Cajal, CSIC, Madrid, Spain
    Genes Dev 5:132-40. 1991
    ..HL I encodes a family of proteins with extensive homology to invertebrate troponin I (TnI)...
  23. pmc A tropomyosin-2 mutation suppresses a troponin I myopathy in Drosophila
    B Naimi
    Department of Biology, University of York, York YO10 5YW, United Kingdom
    Mol Biol Cell 12:1529-39. 2001
    A suppressor mutation, D53, of the held-up(2) allele of the Drosophila melanogaster Troponin I (wupA) gene is described...
  24. doi Human congenital myopathy actin mutants cause myopathy and alter Z-disc structure in Drosophila flight muscle
    Maria Sevdali
    Department of Biology Area 10, University of York, York YO10 5DD, UK
    Neuromuscul Disord 23:243-55. 2013
    ..A single copy of D292V mutant actin rescued the hypercontractile phenotypes caused by TnI and TnT mutants, suggesting that the D292V mutation interferes with thin filament regulation...
  25. doi Evaluation of Drosophila metabolic labeling strategies for in vivo quantitative proteomic analyses with applications to early pupa formation and amino acid starvation
    Ying Che Chang
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    J Proteome Res 12:2138-50. 2013
    ....
  26. pmc Muscles provide protection during microbial infection by activating innate immune response pathways in Drosophila and zebrafish
    Arunita Chatterjee
    Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore 560012, India
    Dis Model Mech 9:697-705. 2016
    ..Our results suggest that physiologically fit muscles might boost the innate immune response of an individual. ..
  27. pmc Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins
    M Aguilera
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002J, Spain
    Genetics 155:1231-44. 2000
    ..In addition to ARI homologues, the RBR signature is also found in the Parkinson-disease-related protein Parkin adjacent to an ubiquitin-like domain, suggesting that the study of this mechanism could be relevant for human pathology...
  28. doi Live imaging of muscles in Drosophila metamorphosis: Towards high-throughput gene identification and function analysis
    Wee Choo Puah
    Imaging Informatics Division, Bioinformatics Institute BII, Agency for Science, Technology and Research A STAR, 30 Biopolis Street, 07 01 Matrix, Singapore 138671, Republic of Singapore Electronic address
    Methods 96:103-17. 2016
    ..We describe mKO2 tagged Cysteine proteinase 1 (Cp1) and Troponin-I (TnI) as examples of proteins showing developmental changes in subcellular localization...
  29. pmc A cis-regulatory mutation in troponin-I of Drosophila reveals the importance of proper stoichiometry of structural proteins during muscle assembly
    Hena Firdaus
    Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore 560 012, India Centre for Life Sciences, Central University of Jharkhand, Ranchi 835 205, India
    Genetics 200:149-65. 2015
    ..We show that fliH is a cis-regulatory mutation of the wings up A (wupA) gene, which codes for the troponin-I protein, one of the troponin complex proteins, involved in ..
  30. doi Raman spectroscopic studies on screening of myopathies
    Rekha Gautam
    Department of Inorganic and Physical Chemistry, Department of Molecular Reproduction, Development and Genetics, and Department of Instrumentation and Applied Physics, Indian Institute of Science, Bangalore, 560012, India
    Anal Chem 87:2187-94. 2015
    ..Raman spectra were collected from indirect flight muscles of mutants, upheld(1) (up(1)), heldup(2) (hdp(2)), myosin heavy chain(7) (Mhc(7)), actin88F(KM88) (Act88F(KM88)), upheld(101) (up(101)), and Canton-S (..
  31. pmc Arrest is a regulator of fiber-specific alternative splicing in the indirect flight muscles of Drosophila
    Sandy T Oas
    Department of Biology, University of New Mexico, Albuquerque, NM 87131
    J Cell Biol 206:895-908. 2014
    ..Our observations provide insight into a transcriptional and splicing regulatory network for muscle fiber specification. ..
  32. ncbi Roles of the troponin isoforms during indirect flight muscle development in Drosophila
    Salam Herojeet Singh
    Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore 560 012, India
    J Genet 93:379-88. 2014
    b>Troponin proteins in cooperative interaction with tropomyosin are responsible for controlling the contraction of the striated muscles in response to changes in the intracellular calcium concentration...
  33. pmc Overexpression Beadex mutations and loss-of-function heldup-a mutations in Drosophila affect the 3' regulatory and coding components, respectively, of the Dlmo gene
    M Shoresh
    Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel
    Genetics 150:283-99. 1998
    ..Dlmo resides in polytene band 17C1-2, where Beadex (Bx) and heldup-a (hdp-a) mutations map...
  34. pmc The nebulin repeat protein Lasp regulates I-band architecture and filament spacing in myofibrils
    Isabelle Fernandes
    Department of Biology, McGill University, Montreal, Quebec, Canada H3A 1B1
    J Cell Biol 206:559-72. 2014
    ..Furthermore, introducing a single amino acid change into the two nebulin repeats of Lasp demonstrated different roles for each domain and established Lasp as a suitable system for studying nebulin repeat function. ..
  35. pmc Galactokinase is a novel modifier of calcineurin-induced cardiomyopathy in Drosophila
    Teresa E Lee
    Department of Cell Biology, Duke University, Durham, North Carolina 27710
    Genetics 198:591-603. 2014
    ....
  36. pmc Disruption of sarcoendoplasmic reticulum calcium ATPase function in Drosophila leads to cardiac dysfunction
    Dennis M Abraham
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 8:e77785. 2013
    ..Thus, we present a cardiac phenotype associated with Drosophila SERCA dysfunction that would serve as additional phenotyping for further large-scale genetic screens for novel modifiers of SERCA function. ..
  37. pmc Purification of cardiac cells from Drosophila embryos
    Anton L Bryantsev
    Department of Biology, University of New Mexico, Albuquerque, NM 87108, USA
    Methods 56:44-9. 2012
    ..In the future, this approach can be used to describe the cardiac transcriptome of Drosophila at distinct stages of embryonic development...
  38. pmc Drosophila muscleblind codes for proteins with one and two tandem zinc finger motifs
    Uwe Irion
    Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS ONE 7:e34248. 2012
    ..1), are not muscle-specific but expressed mainly in epidermal cells, indicating a function for mbl not only in muscles and the nervous system...
  39. ncbi E93K charge reversal on actin perturbs steric regulation of thin filaments
    Anthony Cammarato
    Department of Physiology and Biophysics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    J Mol Biol 347:889-94. 2005
    Contraction in striated muscles is regulated by Ca2+-dependent movement of tropomyosin-troponin on thin filaments...
  40. ncbi Expression of cardiac myosin-binding protein-C (cMyBP-C) in Drosophila as a model for the study of human cardiomyopathies
    Thien Phong Vu Manh
    CNRS, UMR6545, LGPD IBDM, Universite de la Mediterranee, Marseille, France
    Hum Mol Genet 14:7-17. 2005
    ....
  41. pmc Two Drosophila myosin transducer mutants with distinct cardiomyopathies have divergent ADP and actin affinities
    Marieke J Bloemink
    Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
    J Biol Chem 286:28435-43. 2011
    ..This may account for the suppression (A261T) or enhancement (G200D) of the skeletal muscle hypercontraction phenotype induced by the troponin I held-up(2) mutation in Drosophila.
  42. pmc Physiological homology between Drosophila melanogaster and vertebrate cardiovascular systems
    Michael A Choma
    Children s Hospital Boston, Boston, MA 02115, USA
    Dis Model Mech 4:411-20. 2011
    ..To demonstrate homology in heart dysfunction, we showed that, at the pre-pupal stage, a troponin I mutant, held-up2 (hdp2), has impaired systolic and diastolic heart wall velocities...
  43. pmc Drosophila muscle regulation characterized by electron microscopy and three-dimensional reconstruction of thin filament mutants
    Anthony Cammarato
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts 02118 2526, USA
    Biophys J 86:1618-24. 2004
    ..Thin filaments from the Drosophila mutant heldup(2), which possesses a single amino acid conversion in troponin I, were similarly analyzed to assess the Drosophila model genetically...
  44. pmc Sarcomere formation occurs by the assembly of multiple latent protein complexes
    Yanning Rui
    Department of Genetics, Harvard Medical School, Boston, MA, USA
    PLoS Genet 6:e1001208. 2010
    ..Thus, sarcomere formation occurs by the coordinated assembly of multiple latent protein complexes, as opposed to sequential assembly...
  45. doi Drosophila indirect flight muscle specific Act88F actin mutants as a model system for studying congenital myopathies of the human ACTA1 skeletal muscle actin gene
    Sarah E Haigh
    Department of Biology, University of York, York YO10 5DD, UK
    Neuromuscul Disord 20:363-74. 2010
    ..We conclude that the Drosophila indirect flight muscles provide a good model system for studying ACTA1 mutations...
  46. ncbi Diversification and independent evolution of troponin C genes in insects
    Raul Herranz
    Departamento de Bioquímica UAM e Instituto de Investigaciones Biomédicas Alberto Sols UAM CSIC, Facultad de Medicina de la Universidad Autonoma, C Arzobispo Morcillo 4, 28029 Madrid, Spain
    J Mol Evol 60:31-44. 2005
    b>Troponin C (TpnC), the calcium-binding subunit of the troponin regulatory complex in the muscle thin filament, is encoded by multiple genes in insects...
  47. ncbi Calcineurin signaling and NFAT activation in cardiovascular and skeletal muscle development
    Robert A Schulz
    Department of Biochemistry and Molecular Biology, Graduate Program in Genes and Development, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Dev Biol 266:1-16. 2004
    ....
  48. ncbi Genetic approaches to understanding muscle development
    H F Epstein
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030
    Dev Biol 154:231-44. 1992
    ..We discuss examples of each of these genetic approaches as well as the developmental and evolutionary implications of the results...
  49. ncbi Some mutations affecting neural or muscular tissues alter the physiological components of the electroretinogram in Drosophila
    T Homyk
    Department of Biological Sciences, Purdue University, W Lafayette, Indiana 47906
    J Neurogenet 5:37-48. 1989
    ..Mutations bas, rex and sesD delay recovery from the prolonged depolarization afterpotential. The visual defects of mutations elavjl and nbAEE171 are not complemented by lethal mutations, which, presumably, affect other tissues...
  50. pmc Microsatellite variation in North American populations of Drosophila melanogaster
    D B Goldstein
    Department of Biology, Pennsylvania State University, University Park 16802, USA
    Nucleic Acids Res 23:3882-6. 1995
    ....
  51. ncbi Functional relationships between genes of the Shaker gene complex of Drosophila
    J L de la Pompa
    Instituto Cajal, CSIC, Madrid, Spain
    Mol Gen Genet 244:197-204. 1994
    ..The HLI complementation group encodes troponin I. HLII lack-of-function mutations [l(1)174 and l(1)4058] affect nervous system development...
  52. pmc Isolation of RRM-type RNA-binding protein genes and the analysis of their relatedness by using a numerical approach
    Y J Kim
    Department of Biological Sciences, Stanford University, California 94305
    Mol Cell Biol 13:174-83. 1993
    ..This result suggests that we have isolated good candidates for both housekeeping and developmentally important genes involved in RNA metabolism...
  53. pmc scully, an essential gene of Drosophila, is homologous to mammalian mitochondrial type II L-3-hydroxyacyl-CoA dehydrogenase/amyloid-beta peptide-binding protein
    L Torroja
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    J Cell Biol 141:1009-17. 1998
    ..Some of these phenotypes are very similar to those present in human pathologies caused by beta-oxidation disorders...
  54. pmc The haplolethal region at the 16F gene cluster of Drosophila melanogaster: structure and function
    A Prado
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    Genetics 151:163-75. 1999
    ..4-kb window of mostly noncoding sequences within the wupA transcription unit that encodes the muscle protein troponin I (TNI)...
  55. ncbi Actin residue glu(93) is identified as an amino acid affecting myosin binding
    A Razzaq
    Department of Biology, University of York, P O Box 373, York YO10 5YW, United Kingdom
    J Biol Chem 274:28321-8. 1999
    ..C. (1995) Biophys J. 68, (suppl.) 2-7) that actin residue Glu(93) is part of the secondary myosin binding site and suggest that myosin binding occurs first at the primary myosin binding site and then at the secondary site...
  56. pmc Two functionally identical modular enhancers in Drosophila troponin T gene establish the correct protein levels in different muscle types
    Jose Antonio Mas
    Departamento de Bioquímica and Instituto de Investigaciones Biomédicas, Facultad de Medicina, Universidad Autonoma de Madrid, UAM CSIC, 28029 Madrid, Spain
    Mol Biol Cell 15:1931-45. 2004
    ..This mechanism is not exclusive to the Troponin T gene, but is also relevant to the muscle-specific Troponin I gene...
  57. pmc CF2 represses Actin 88F gene expression and maintains filament balance during indirect flight muscle development in Drosophila
    Kathleen M Gajewski
    Department of Systems Biology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    PLoS ONE 5:e10713. 2010
    ....
  58. pmc Characterization of a hypercontraction-induced myopathy in Drosophila caused by mutations in Mhc
    Enrico S Montana
    Picower Center for Learning and Memory, MIT, 50 Ames St, Bldg E18 672, Cambridge, MA 02139, USA
    J Cell Biol 164:1045-54. 2004
    ..Characterization of these new Mhc alleles suggests that hypercontraction occurs via a mechanism, which is molecularly distinct from mutants identified previously in troponin I and troponin T.
  59. ncbi Mutations of Drosophila melanogaster that affect muscles
    I I Deak
    J Embryol Exp Morphol 40:35-63. 1977
    ..flight muscle fibres, a third (upheld) is required for the gross organization of muscle structure, another (heldup) is involved in the maintenance of muscle structure once formed, and the fifth seems to be necessary for the ..
  60. ncbi The coevolution of insect muscle TpnT and TpnI gene isoforms
    Raul Herranz
    Departamento de Bioquimica, Instituto de Investigaciones Biomédicas Alberto Sols UAM CSIC, Facultad de Medicina, Universidad Autonoma de Madrid, C Arzobispo Morcillo 4, 28029 Madrid, Spain
    Mol Biol Evol 22:2231-42. 2005
    In bilaterians, the main regulator of muscle contraction is the troponin (Tpn) complex, comprising three closely interacting subunits (C, T, and I)...
  61. ncbi The structural role of high molecular weight tropomyosins in dipteran indirect flight muscle and the effect of phosphorylation
    Jesus Mateos
    Departamento de Bioquímica UAM e Instituto Alberto Sols UAM CSIC, Universidad Autonoma de Madrid, Madrid, Spain
    J Muscle Res Cell Motil 27:189-201. 2006
    ..Instead these sequences are found at the 3' end of the troponin I gene...
  62. pmc A Drosophila melanogaster model of spinal muscular atrophy reveals a function for SMN in striated muscle
    T K Rajendra
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    J Cell Biol 176:831-41. 2007
    ..The sarcomeric localization of Smn is conserved in mouse myofibrils. These observations suggest a muscle-specific function for SMN and underline the importance of this tissue in modulating SMA severity...
  63. pmc Aberrant splicing of an alternative exon in the Drosophila troponin-T gene affects flight muscle development
    Upendra Nongthomba
    Department of Biology, University of York, York, YO10 5DD, United Kingdom
    Genetics 177:295-306. 2007
    ..The absence of TnT mRNA in up1 IFM reduces mRNA levels of an IFM-specific troponin I (TnI) isoform, but not actin, tropomyosin, or troponin C, suggesting a mechanism controlling expression of TnT ..
  64. ncbi Direct measurement of the performance of the Drosophila jump muscle in whole flies
    Christopher J H Elliott
    Department of Biology, University of York, York, United Kingdom
    Fly (Austin) 1:68-74. 2007
    ..Developing an ergometer for Drosophila offers novel opportunities to assess the functional consequences of mutations in muscle proteins, synaptic physiology, neuromuscular development and aging...
  65. pmc Detection of transgenerational spermatogenic inheritance of adult male acquired CNS gene expression characteristics using a Drosophila systems model
    Abhay Sharma
    Institute of Genomics and Integrative Biology, Council of Scientific and Industrial Research, Delhi, India
    PLoS ONE 4:e5763. 2009
    ..The finding that adult acquired transcriptomic alteration in soma is spermatogenically inherited across generations has potential implications in human health and evolution...
  66. doi Troponin I and Tropomyosin regulate chromosomal stability and cell polarity
    Virender Kumar Sahota
    Cajal Institute, CSIC, Dr Arce 37, Madrid 28002, Spain
    J Cell Sci 122:2623-31. 2009
    ..Members of this complex in Drosophila include the actin-binding protein Troponin I (TnI), and two Tropomyosins (Tm1 and Tm2), which are thought to form heterodimers...

Patents1

  1. ANTISENSE-OLIGONUCLEOTIDES FOR THE TREATMENT OF IMMUNOSUPPRESSIVE EFFECTS OF TRANSFORMING GROWTH FACTOR--g(b) (TGF--g(b))
    Patent Number: WO9425578-A1; Date:1994-11-10