wrapper

Summary

Gene Symbol: wrapper
Description: CG10382 gene product from transcript CG10382-RA
Alias: CG10382, CT19059, Dmel\CG10382, Wrapper, CG10382 gene product from transcript CG10382-RA, CG10382-PA, wrapper-PA
Species: fruit fly

Top Publications

  1. pmc Drosophila hedgehog signaling and engrailed-runt mutual repression direct midline glia to alternative ensheathing and non-ensheathing fates
    JOSEPH D WATSON
    Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Development 138:1285-95. 2011
  2. pmc Identification of motifs that are conserved in 12 Drosophila species and regulate midline glia vs. neuron expression
    Patricia Estes
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695 7614, USA
    Genetics 178:787-99. 2008
  3. ncbi Slit is the midline repellent for the robo receptor in Drosophila
    T Kidd
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 96:785-94. 1999
  4. ncbi Wrapper, a novel member of the Ig superfamily, is expressed by midline glia and is required for them to ensheath commissural axons in Drosophila
    J N Noordermeer
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Neuron 21:991-1001. 1998
  5. pmc Overlapping functions of microRNAs in control of apoptosis during Drosophila embryogenesis
    W Ge
    Institute of Molecular Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore
    Cell Death Differ 19:839-46. 2012
  6. pmc Time-lapse imaging reveals stereotypical patterns of Drosophila midline glial migration
    Scott R Wheeler
    Department of Biochemistry and Biophysics, Program in Molecular Biology and Biotechnology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Dev Biol 361:232-44. 2012
  7. pmc Mastermind mutations generate a unique constellation of midline cells within the Drosophila CNS
    Yi Zhang
    Department of Genetics, North Carolina State University, Raleigh, North Carolina, United States of America
    PLoS ONE 6:e26197. 2011
  8. doi Drosophila morgue influences cell numbers and positions in the embryonic nervous system
    Barbara A Schreader
    Biology Department, University of Massachusetts, Amherst MA, USA
    Int J Dev Biol 54:1425-33. 2010
  9. doi The guanine exchange factor vav controls axon growth and guidance during Drosophila development
    Marianne Malartre
    Centro Andaluz de Biologia del Desarrollo, Consejo Superior de Investigaciones Cientificas, Universidad Pablo de Olavide, 41013 Sevilla, Spain
    J Neurosci 30:2257-67. 2010
  10. ncbi Gliatrophic and gliatropic roles of PVF/PVR signaling during axon guidance
    A R Learte
    NeuroDevelopment Group, School of Biosciences, University of Birmingham, Birmingham, United Kingdom
    Glia 56:164-76. 2008

Research Grants

Scientific Experts

  • GREG BASHAW
  • Lee G Fradkin
  • Patricia Estes
  • Margaret J Sonnenfeld
  • Scott R Wheeler
  • Stephen T Crews
  • Anita Hsouna
  • Mark F A VanBerkum
  • Tobias Stork
  • W Ge
  • Yi Zhang
  • Jana Slováková
  • JOSEPH D WATSON
  • Barbara A Schreader
  • Marianne Malartre
  • You Seung Kim
  • A R Learte
  • Janice L Fritz
  • Crystal M Miller
  • Rene R Wouda
  • Christian Klämbt
  • Kristina Schimmelpfeng
  • Marco Gallio
  • Heather C Sears
  • Kristin White
  • Daniel Crowner
  • Torsten Bossing
  • Zachary Wills
  • S F Lim
  • R Weng
  • S M Cohen
  • M Buescher
  • Joseph C Pearson
  • Y W Chen
  • R Zhang
  • Amanda Tapp
  • Ana Carmena
  • Randi Wheatley
  • Stephanie B Stagg
  • Eric Fulkerson
  • Derya Ayaz
  • Maria Dolores Martín-Bermudo
  • J L Fritz
  • Q Sun
  • Yiqin Wang
  • Joanna Grigas
  • Fatima Fernandez Amador
  • Stephanie Carter
  • John R Nambu
  • Kevin Blauth
  • Elke Naffin
  • Stephanie Wenderdel
  • Manzoor A Bhat
  • Stephen L Rogers
  • Floriano Rodrigues
  • Marion Silies
  • Silke Thomas
  • Swati Banerjee
  • Heather T Broihier
  • Andrea Page-McCaw
  • Monique R K S Bansraj
  • Anja W M de Jong
  • T Kidd
  • Jasprina N Noordermeer
  • M G Forero
  • A Hidalgo
  • K S Bland
  • C S Goodman
  • Mareike Strunk
  • J N Noordermeer
  • Christos Samakovlis
  • Camilla Englund
  • Per Kylsten
  • Paul A Garrity
  • Caleb J Kennedy
  • Jannette Rusch
  • Buzz Baum
  • David Van Vactor
  • Ananda K Seneviratne
  • Mark Emerson
  • Scott Goeke
  • Andrea H Brand
  • Jay Bikoff
  • Norbert Perrimon
  • Edward Giniger
  • Knut Madden
  • S Bahri
  • M F VanBerkum
  • K Zinn
  • W Chia

Detail Information

Publications31

  1. pmc Drosophila hedgehog signaling and engrailed-runt mutual repression direct midline glia to alternative ensheathing and non-ensheathing fates
    JOSEPH D WATSON
    Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Development 138:1285-95. 2011
    ....
  2. pmc Identification of motifs that are conserved in 12 Drosophila species and regulate midline glia vs. neuron expression
    Patricia Estes
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695 7614, USA
    Genetics 178:787-99. 2008
    ..Here, we examine regulation of the midline gene, wrapper, required for both neuron-glia interactions and viability of midline glia...
  3. ncbi Slit is the midline repellent for the robo receptor in Drosophila
    T Kidd
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 96:785-94. 1999
    ..Slit appears to function as a short-range repellent controlling axon crossing of the midline and as a long-range chemorepellent controlling mesoderm migration away from the midline...
  4. ncbi Wrapper, a novel member of the Ig superfamily, is expressed by midline glia and is required for them to ensheath commissural axons in Drosophila
    J N Noordermeer
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Neuron 21:991-1001. 1998
    ..In many segments, a few of the glia do not enwrap the axons, and these cells die. The wrapper gene encodes a novel member of the immunoglobulin (Ig) superfamily...
  5. pmc Overlapping functions of microRNAs in control of apoptosis during Drosophila embryogenesis
    W Ge
    Institute of Molecular Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore
    Cell Death Differ 19:839-46. 2012
    ..These findings demonstrate that the activity of the proapoptotic genes is kept in check by miR-6/11 to ensure normal development...
  6. pmc Time-lapse imaging reveals stereotypical patterns of Drosophila midline glial migration
    Scott R Wheeler
    Department of Biochemistry and Biophysics, Program in Molecular Biology and Biotechnology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Dev Biol 361:232-44. 2012
    ..Drosophila MG are homologous in structure and function to the glial-like cells that populate the vertebrate CNS floorplate, and study of Drosophila MG will provide useful insights into floorplate development and function...
  7. pmc Mastermind mutations generate a unique constellation of midline cells within the Drosophila CNS
    Yi Zhang
    Department of Genetics, North Carolina State University, Raleigh, North Carolina, United States of America
    PLoS ONE 6:e26197. 2011
    ..Within the Drosophila midline cell lineage, which bisects the two symmetrical halves of the central nervous system, Notch is required for initial cell specification and subsequent differentiation of many midline lineages...
  8. doi Drosophila morgue influences cell numbers and positions in the embryonic nervous system
    Barbara A Schreader
    Biology Department, University of Massachusetts, Amherst MA, USA
    Int J Dev Biol 54:1425-33. 2010
    ..Taken together, these diverse phenotypes and distribution patterns suggest pleiotropic functions for Morgue...
  9. doi The guanine exchange factor vav controls axon growth and guidance during Drosophila development
    Marianne Malartre
    Centro Andaluz de Biologia del Desarrollo, Consejo Superior de Investigaciones Cientificas, Universidad Pablo de Olavide, 41013 Sevilla, Spain
    J Neurosci 30:2257-67. 2010
    ..Thus, we propose that vav acts in coordination with other GEFs to regulate axon growth and guidance during development by linking guidance signals to the cytoskeleton via the modulation of Rac activity...
  10. ncbi Gliatrophic and gliatropic roles of PVF/PVR signaling during axon guidance
    A R Learte
    NeuroDevelopment Group, School of Biosciences, University of Birmingham, Birmingham, United Kingdom
    Glia 56:164-76. 2008
    ..PVR signaling promotes midline glia survival through AKT and ERK pathways. This work shows that the PVR/PDGFR pathway plays conserved gliatrophic and gliatropic roles in subsets of glial cells in flies and vertebrates...
  11. ncbi Constitutively active myosin light chain kinase alters axon guidance decisions in Drosophila embryos
    You Seung Kim
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
    Dev Biol 249:367-81. 2002
    ..These results confirm that proper pathway formation requires careful regulation of MLCK and/or myosin II activity and suggest that regulation occurs in direct response to attractive and repulsive cues...
  12. ncbi Receptor tyrosine phosphatases regulate axon guidance across the midline of the Drosophila embryo
    Q Sun
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Development 127:801-12. 2000
    ....
  13. ncbi Calmodulin and son of sevenless dependent signaling pathways regulate midline crossing of axons in the Drosophila CNS
    J L Fritz
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    Development 127:1991-2000. 2000
    ..These data suggest that Calmodulin and Son of sevenless signaling pathways function to interpret midline repulsive cues which prevent axons crossing the midline...
  14. pmc A novel Dbl family RhoGEF promotes Rho-dependent axon attraction to the central nervous system midline in Drosophila and overcomes Robo repulsion
    G J Bashaw
    Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 155:1117-22. 2001
    ..Surprisingly, evidence from genetic, biochemical, and cell culture experiments suggests that the promotion of axon attraction by GEF64C is dependent on the activation of Rho, but not Rac or Cdc42...
  15. doi Canoe functions at the CNS midline glia in a complex with Shotgun and Wrapper-Nrx-IV during neuron-glia interactions
    Jana Slováková
    Instituto de Neurociencias de Alicante, CSIC UMH, Sant Joan d Alacant, Alicante, Spain
    Development 138:1563-71. 2011
    ..assays unveil Cno function as a novel regulator of neuron-glia interactions, forming a complex with Shg, Wrapper and Neurexin IV, the homolog of vertebrate Caspr/paranodin...
  16. ncbi Signaling survival: how axons rescue their glia
    Kristin White
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Dev Cell 2:128-30. 2002
    ..Work published in this issue of Developmental Cell confirms that neurons can provide trophic support for glia in Drosophila, and fills in important molecular details of this interaction...
  17. ncbi Lola regulates midline crossing of CNS axons in Drosophila
    Daniel Crowner
    Division of Basic Sciences, Program in Developmental Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, N, Seattle, WA 98109, USA
    Development 129:1317-25. 2002
    ....
  18. ncbi Dephrin, a transmembrane ephrin with a unique structure, prevents interneuronal axons from exiting the Drosophila embryonic CNS
    Torsten Bossing
    Wellcome Trust Cancer Research UK Institute and Department of Genetics, Cambridge University, Tennis Court Road, Cambridge, CB2 1QR, UK
    Development 129:4205-18. 2002
    ..We propose that the longitudinal tracts in the Drosophila CNS are moulded by a repulsive outer border of Dephrin expression...
  19. pmc Neurexin IV and Wrapper interactions mediate Drosophila midline glial migration and axonal ensheathment
    Scott R Wheeler
    Department of Biochemistry and Biophysics, The University of North Carolina, Chapel Hill, NC 27599, USA
    Development 136:1147-57. 2009
    ..The membrane-anchored protein Wrapper is present in Drosophila midline glia and is required for ensheathment of commissural axons...
  20. doi Drosophila Neurexin IV stabilizes neuron-glia interactions at the CNS midline by binding to Wrapper
    Tobias Stork
    Institut fur Neurobiologie, Universitat Munster, Badestrasse 9, D 48149 Munster, Germany
    Development 136:1251-61. 2009
    ..depends on the interaction of the neuronal transmembrane protein Neurexin IV with the glial Ig-domain protein Wrapper. Although Neurexin IV has been previously described to be an essential component of epithelial septate junctions (..
  21. doi Src family kinases are required for WNT5 signaling through the Derailed/RYK receptor in the Drosophila embryonic central nervous system
    Rene R Wouda
    Laboratory of Developmental Neurobiology, Department of Molecular and Cell Biology, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Development 135:2277-87. 2008
    ..Together, these findings indicate that the Src family kinases play novel roles in WNT5/Derailed-mediated signaling...
  22. ncbi Regulation of rho family GTPases is required to prevent axons from crossing the midline
    Janice L Fritz
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
    Dev Biol 252:46-58. 2002
    ..Midline repulsion appears to require down-regulation of Drac1 and Dcdc42 and activation of Rho...
  23. doi Abelson tyrosine kinase and Calmodulin interact synergistically to transduce midline guidance cues in the Drosophila embryonic CNS
    Anita Hsouna
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    Int J Dev Neurosci 26:345-54. 2008
    ....
  24. ncbi Matrix metalloproteinases promote motor axon fasciculation in the Drosophila embryo
    Crystal M Miller
    Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Development 135:95-109. 2008
    ..These data demonstrate that MMP activity is essential for embryonic motor axon fasciculation...
  25. ncbi A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding
    Zachary Wills
    Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Neuron 36:611-22. 2002
    ..These studies identify Capulet as part of an emerging pathway linking guidance signals to regulation of cytoskeletal dynamics and suggest that the Abl pathway mediates signals downstream of multiple Roundabout receptors...
  26. ncbi Mummy encodes an UDP-N-acetylglucosamine-dipohosphorylase and is required during Drosophila dorsal closure and nervous system development
    Kristina Schimmelpfeng
    Institut fur Neurobiologie, Universitat Munster, Badestr 9, 48149 Munster, Germany
    Mech Dev 123:487-99. 2006
    ..These phenotypes correlate well with specific glycosylation and GPI-anchorage defects in mummy mutants...
  27. ncbi The jing and ras1 pathways are functionally related during CNS midline and tracheal development
    Margaret J Sonnenfeld
    Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ont, Canada
    Mech Dev 121:1531-47. 2004
    ..Egfr pathway genes and jing show dominant genetic interactions in the trachea and CNS midline. Together, these results show that jing regulates signal transduction in developing midline and tracheal cells...
  28. ncbi The Drosophila Wnt5 protein mediates selective axon fasciculation in the embryonic central nervous system
    Lee G Fradkin
    Department of Molecular and Cell Biology, Leiden University Medical Center, 2333 AL Leiden, The Netherlands
    Dev Biol 272:362-75. 2004
    ..Finally, we demonstrate that transcriptional repression of wnt5 in AC neurons by the recently described Wnt5 receptor, Derailed, contributes to this largely posterior commissural localization of Wnt5 protein...
  29. ncbi Rhomboid 3 orchestrates Slit-independent repulsion of tracheal branches at the CNS midline
    Marco Gallio
    Department of Developmental Biology, Wenner Gren Institute, Stockholm University, S 106 96 Stockholm, Sweden
    Development 131:3605-14. 2004
    ..We propose that Egfr activation provides a necessary switch for the interpretation of a yet unknown repellent function of the midline...
  30. ncbi Abelson tyrosine kinase is required to transduce midline repulsive cues
    Anita Hsouna
    Department of Biological Sciences, Wayne State University, 5047 Gullen Mall, Detroit, Michigan 48202, USA
    J Neurobiol 57:15-30. 2003
    ..How Abl functions in this role is not yet clear, but we suggest that Abl may help regulate cytoskeletal dynamics underlying a growth cone's response to midline cues...
  31. ncbi Macrophage-mediated corpse engulfment is required for normal Drosophila CNS morphogenesis
    Heather C Sears
    Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue 68 230B, Cambridge, MA 02139, USA
    Development 130:3557-65. 2003
    ..These data indicate that macrophage-mediated clearance of cell corpses is required for proper morphogenesis of the Drosophila CNS...

Research Grants1

  1. Mechanisms of Slit-Roundabout Mediated Axon Repulsion
    GREG BASHAW; Fiscal Year: 2008
    ..abstract_text> ..