wisp

Summary

Gene Symbol: wisp
Description: wispy
Alias: CG15737, DmCG15737, Dmel\CG15737, TAMP, Wisp, fs(1)M19, CG15737 gene product from transcript CG15737-RC, CG15737-PA, CG15737-PB, CG15737-PC, WISPY, female sterile(1)M19, temprano, toll pathway activation mediating protein, wisp-PA, wisp-PB, wisp-PC
Species: fruit fly

Top Publications

  1. pmc subito encodes a kinesin-like protein required for meiotic spindle pole formation in Drosophila melanogaster
    Kelly L Giunta
    Waksman Institute and Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA
    Genetics 160:1489-501. 2002
  2. pmc Wispy, the Drosophila homolog of GLD-2, is required during oogenesis and egg activation
    Jun Cui
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Genetics 178:2017-29. 2008
  3. doi PAP- and GLD-2-type poly(A) polymerases are required sequentially in cytoplasmic polyadenylation and oogenesis in Drosophila
    Perrine Benoit
    mRNA Regulation and Development, Institut de Genetique Humaine, CNRS UPR 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Development 135:1969-79. 2008
  4. pmc Cytoplasmic polyadenylation is a major mRNA regulator during oogenesis and egg activation in Drosophila
    Jun Cui
    Department of Molecular Biology and Genetics, Biotechnology Bldg, Cornell University, Ithaca, NY 14853, United States
    Dev Biol 383:121-31. 2013
  5. doi Cytoplasmic polyadenylation element binding proteins in development, health, and disease
    Maria Ivshina
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605 email
    Annu Rev Cell Dev Biol 30:393-415. 2014
  6. pmc Adenylation of maternally inherited microRNAs by Wispy
    Mihye Lee
    Center for RNA Research, Institute for Basic Science, Seoul 151 742, Korea School of Biological Sciences, Seoul National University, Seoul 151 742, Korea
    Mol Cell 56:696-707. 2014
  7. doi Wispy and Orb cooperate in the cytoplasmic polyadenylation of localized gurken mRNA
    Amanda Norvell
    Department of Biology, The College of New Jersey, Ewing, New Jersey
    Dev Dyn 244:1276-85. 2015
  8. pmc Genome-wide analysis of mRNA decay patterns during early Drosophila development
    Stefan Thomsen
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Genome Biol 11:R93. 2010
  9. pmc The functioning of the Drosophila CPEB protein Orb is regulated by phosphorylation and requires casein kinase 2 activity
    Li Chin Wong
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
    PLoS ONE 6:e24355. 2011
  10. pmc The Drosophila melanogaster seminal fluid protease "seminase" regulates proteolytic and post-mating reproductive processes
    Brooke A LaFlamme
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA
    PLoS Genet 8:e1002435. 2012

Research Grants

  1. TRANSLATIONAL CONTROL IN EARLY MAMMALIAN DEVELOPMENT
    Joel Richter; Fiscal Year: 2001
  2. RNA Localization 2006
    Joel Richter; Fiscal Year: 2007
  3. RNA and the Etiology of Disease
    Joel Richter; Fiscal Year: 2008

Scientific Experts

  • Joel Richter
  • Stefan Thomsen
  • Jun Cui
  • Mariana F Wolfner
  • Amanda Norvell
  • Maria Ivshina
  • Mihye Lee
  • Brooke A LaFlamme
  • Li Chin Wong
  • Perrine Benoit
  • Marvin Wickens
  • Wael Tadros
  • Letitia Thompson
  • Jason Wong
  • Kristen Randolph
  • Yeon Choi
  • Paul Lasko
  • Antonio J Giraldez
  • Kelly L Giunta
  • Dinshaw J Patel
  • Minsun Jeong
  • Jihye Yang
  • Kijun Kim
  • Hui Yang
  • Jaechul Lim
  • V Narry Kim
  • Tuan Anh Nguyen
  • Hua Jin
  • Liaoteng Wang
  • Jeffrey A Pleiss
  • Caroline V Sartain
  • K Ravi Ram
  • Alexandre Costa
  • Saw Kyin
  • Ali Sarkeshik
  • Paul Schedl
  • John Yates
  • David Perlman
  • Ian McLeod
  • A E Brent
  • Jae Eun Kwak
  • Martine Simonelig
  • Kritika E Kumar
  • Vanessa L Horner
  • Katharine L Sackton
  • Catherine Papin
  • Arash Bashirullah
  • Simon A Houston
  • Howard D Lipshitz
  • Bruce H Reed
  • Ramona L Cooperstock
  • Jennifer L Semotok
  • Gayathri Subramanian
  • Judith Kimble
  • Elizabeth A Manheim
  • Janet K Jang
  • Lisa C Kadyk
  • Christian R Eckmann
  • Kim S McKim
  • A MacQueen
  • T Hazelrigg
  • J D Mohler

Detail Information

Publications14

  1. pmc subito encodes a kinesin-like protein required for meiotic spindle pole formation in Drosophila melanogaster
    Kelly L Giunta
    Waksman Institute and Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA
    Genetics 160:1489-501. 2002
    ..sub is also required for the early embryonic divisions but is otherwise dispensable for most mitotic divisions...
  2. pmc Wispy, the Drosophila homolog of GLD-2, is required during oogenesis and egg activation
    Jun Cui
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Genetics 178:2017-29. 2008
    ..b>wispy (wisp) maternal-effect mutations in Drosophila block development during the egg-to-embryo transition...
  3. doi PAP- and GLD-2-type poly(A) polymerases are required sequentially in cytoplasmic polyadenylation and oogenesis in Drosophila
    Perrine Benoit
    mRNA Regulation and Development, Institut de Genetique Humaine, CNRS UPR 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Development 135:1969-79. 2008
    ..We show that the female germline GLD-2 is encoded by wispy. Wispy acts as a poly(A) polymerase in a tethering assay and in vivo for cytoplasmic polyadenylation of specific ..
  4. pmc Cytoplasmic polyadenylation is a major mRNA regulator during oogenesis and egg activation in Drosophila
    Jun Cui
    Department of Molecular Biology and Genetics, Biotechnology Bldg, Cornell University, Ithaca, NY 14853, United States
    Dev Biol 383:121-31. 2013
    ..b>WISPY is a GLD-2 enzyme that acts in the Drosophila female germline and is required for the completion of the egg-to-..
  5. doi Cytoplasmic polyadenylation element binding proteins in development, health, and disease
    Maria Ivshina
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605 email
    Annu Rev Cell Dev Biol 30:393-415. 2014
    ..We review the biochemical features of the CPEB proteins, discuss their activities in several biological systems, and illustrate how understanding CPEB activity in model organisms has an important impact on neurological disease. ..
  6. pmc Adenylation of maternally inherited microRNAs by Wispy
    Mihye Lee
    Center for RNA Research, Institute for Basic Science, Seoul 151 742, Korea School of Biological Sciences, Seoul National University, Seoul 151 742, Korea
    Mol Cell 56:696-707. 2014
    ..Maternal microRNA adenylation is widely conserved in fly, sea urchin, and mouse. We identify Wispy, a noncanonical poly(A) polymerase, as the enzyme responsible for microRNA adenylation in flies...
  7. doi Wispy and Orb cooperate in the cytoplasmic polyadenylation of localized gurken mRNA
    Amanda Norvell
    Department of Biology, The College of New Jersey, Ewing, New Jersey
    Dev Dyn 244:1276-85. 2015
    ....
  8. pmc Genome-wide analysis of mRNA decay patterns during early Drosophila development
    Stefan Thomsen
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Genome Biol 11:R93. 2010
    ....
  9. pmc The functioning of the Drosophila CPEB protein Orb is regulated by phosphorylation and requires casein kinase 2 activity
    Li Chin Wong
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
    PLoS ONE 6:e24355. 2011
    ..isoforms are in slowly sedimenting complexes that contain the translational repressor Bruno, while the hyperphosphorylated isoforms assemble into large complexes that co-sediment with polysomes and contain the Wisp poly(A) polymerase.
  10. pmc The Drosophila melanogaster seminal fluid protease "seminase" regulates proteolytic and post-mating reproductive processes
    Brooke A LaFlamme
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA
    PLoS Genet 8:e1002435. 2012
    ..These results point to an important role for proteolysis among insect SFPs and suggest that protease cascades may be a mechanism for precise temporal regulation of multiple post-mating responses in females...
  11. pmc Developmental genetics of the Drosophila egg. I. Identification of 59 sex-linked cistrons with maternal effects on embryonic development
    J D Mohler
    Genetics 85:259-72. 1977
    ..The mutant strains are potentially important material for the study of developing egg envelopes and for furthering the analysis of causation in embryogenesis and its origins in oogenesis...
  12. pmc The Drosophila wispy gene is required for RNA localization and other microtubule-based events of meiosis and early embryogenesis
    A E Brent
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Genetics 154:1649-62. 2000
    ..We describe a new gene, wispy, required for localization of mRNAs to both poles of the egg...
  13. ncbi A regulatory cytoplasmic poly(A) polymerase in Caenorhabditis elegans
    Liaoteng Wang
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Nature 419:312-6. 2002
    ..We suggest that GLD-2 is the prototype for a class of regulatory cytoplasmic PAPs that are recruited to specific mRNAs by a binding partner, thereby targeting those mRNAs for polyadenylation and increased expression...
  14. pmc Regulation of maternal transcript destabilization during egg activation in Drosophila
    Wael Tadros
    Program in Developmental Biology, Research Institute, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Genetics 164:989-1001. 2003
    ....

Research Grants3

  1. TRANSLATIONAL CONTROL IN EARLY MAMMALIAN DEVELOPMENT
    Joel Richter; Fiscal Year: 2001
    ..Finally, an mRNA that is deadenylated and stored in a dormant form in mouse oocytes undergoes prior CPE-mediated deadenylation. The possible role of mCPEB in the process will be assessed. ..
  2. RNA Localization 2006
    Joel Richter; Fiscal Year: 2007
    ..The cross-disciplinary nature of this meeting will be attractive to molecular, cellular, developmental, and neurobiological scientists. [unreadable] [unreadable] [unreadable] [unreadable]..
  3. RNA and the Etiology of Disease
    Joel Richter; Fiscal Year: 2008
    ..The meeting is cross-disciplinary in its approach, which is essential for combating human disease. [unreadable] [unreadable] [unreadable] [unreadable]..