wg

Summary

Gene Symbol: wg
Description: wingless
Alias: CG4889, DWint-1, DWnt-1, Dint-1, Dm Wg, Dm-1, Dmel\CG4889, Gla, WNT, Wnt, Wnt-1, Wnt/Wg, Wnt1, beta-catenin, dWnt, int-1, l(2)02657, l(2)SH1281, l(2)SH2 1281, l(2)rO727, l(2)wg, spd, wgl, wnt, wnt1, CG4889 gene product from transcript CG4889-RA, CG4889-PA, Wnt-1, bristled, complementation group I, flag, glazed, lethal (2) SH1281, spade, sternopleural, wg-PA
Species: fruit fly

Top Publications

  1. ncbi Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    A H Brand
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Development 118:401-15. 1993
  2. ncbi Drosophila dumbfounded: a myoblast attractant essential for fusion
    M Ruiz-Gomez
    Department of Zoology, University of Cambridge, United Kingdom
    Cell 102:189-98. 2000
  3. ncbi The sterol-sensing domain: multiple families, a unique role?
    Patricia E Kuwabara
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Trends Genet 18:193-201. 2002
  4. ncbi Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase Dronc in a nonapoptotic role
    Jun R Huh
    Division of Biology, MC156 29, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Curr Biol 14:1262-6. 2004
  5. ncbi Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling
    Eunjoo Cho
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 131:4489-500. 2004
  6. ncbi Mutations affecting segment number and polarity in Drosophila
    C Nusslein-Volhard
    Nature 287:795-801. 1980
  7. ncbi Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing
    J F de Celis
    Department of Genetics, University of Cambridge, UK
    Development 124:3241-51. 1997
  8. ncbi Secretion of Wnt ligands requires Evi, a conserved transmembrane protein
    Kerstin Bartscherer
    German Cancer Research Center, Boveri Group Signaling and Functional Genomics, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Cell 125:523-33. 2006
  9. ncbi Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing
    T Adachi-Yamada
    Division of Biological Science, Graduate School of Science, Nagoya University, Japan Science and Technology Corporation
    Nature 400:166-9. 1999
  10. ncbi Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors
    M S Halfon
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Cell 103:63-74. 2000

Research Grants

  1. TISSUE SPECIFICITY OF WINGLESS SIGNALING IN DROSOPHILA
    Kenneth Cadigan; Fiscal Year: 2005
  2. Wnt and beta-Catenin Signaling in Development/Disease
    Mariann Bienz; Fiscal Year: 2006
  3. GENETIC CONTROL OF CELL FATE DIVERSITY IN DROSOPHILA
    Amy Bejsovec; Fiscal Year: 2003
  4. Identification of new Wnt signaling components
    Kenneth Cadigan; Fiscal Year: 2006
  5. Analysis of fringe-dependent cell-signaling
    Kenneth Irvine; Fiscal Year: 2004
  6. CONFOCAL MICROSCOPE FOR LIVE CELL & MULTIWAVELENGTH WORK
    Mark Peifer; Fiscal Year: 2001
  7. Identification of extrinsic signals in blood formation
    Jan Christian; Fiscal Year: 2006
  8. BH3-only protein BNIP3 in tumor progression
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2006
  9. Viral Immunity in Drosophila
    Norbert Perrimon; Fiscal Year: 2007
  10. Organogenesis Screen Using Tissue-Specific Zebrafish
    Jau Nian Chen; Fiscal Year: 2005

Detail Information

Publications199 found, 100 shown here

  1. ncbi Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    A H Brand
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Development 118:401-15. 1993
    ..We have directed expression of an activated form of the Dras2 protein, resulting in dominant eye and wing defects that can be used in screens to identify other members of the Dras2 signal transduction pathway...
  2. ncbi Drosophila dumbfounded: a myoblast attractant essential for fusion
    M Ruiz-Gomez
    Department of Zoology, University of Cambridge, United Kingdom
    Cell 102:189-98. 2000
    ..duf encodes a member of the immunoglobulin superfamily of proteins that is an attractant for fusion-competent myoblasts. It is expressed by founder cells and serves to attract clusters of myoblasts from which myotubes form by fusion...
  3. ncbi The sterol-sensing domain: multiple families, a unique role?
    Patricia E Kuwabara
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Trends Genet 18:193-201. 2002
    ..This article discusses how the SSD appears to function as a regulatory domain involved in linking vesicle trafficking and protein localization with such varied processes as cholesterol homeostasis, cell signalling and cytokinesis...
  4. ncbi Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase Dronc in a nonapoptotic role
    Jun R Huh
    Division of Biology, MC156 29, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Curr Biol 14:1262-6. 2004
    ..We speculate that dying cells may communicate cell fate or behavior instructions to their neighbors in other contexts as well...
  5. ncbi Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling
    Eunjoo Cho
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 131:4489-500. 2004
    ....
  6. ncbi Mutations affecting segment number and polarity in Drosophila
    C Nusslein-Volhard
    Nature 287:795-801. 1980
    ....
  7. ncbi Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing
    J F de Celis
    Department of Genetics, University of Cambridge, UK
    Development 124:3241-51. 1997
    ..Thus the combined effects of Notch and its target genes cut and wingless regulate the expression of Notch ligands which restrict Notch activity to the dorsoventral boundary...
  8. ncbi Secretion of Wnt ligands requires Evi, a conserved transmembrane protein
    Kerstin Bartscherer
    German Cancer Research Center, Boveri Group Signaling and Functional Genomics, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Cell 125:523-33. 2006
    b>Wnt signaling pathways are important for multiple biological processes during development and disease. Wnt proteins are secreted factors that activate target-gene expression in both a short- and long-range manner...
  9. ncbi Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing
    T Adachi-Yamada
    Division of Biological Science, Graduate School of Science, Nagoya University, Japan Science and Technology Corporation
    Nature 400:166-9. 1999
    ..In Drosophila, Decapentaplegic (Dpp; a homologue of transforming growth factor-beta) and Wingless (Wg; a Wnt homologue) proteins are secretory morphogens that act cooperatively to induce formation of the proximodistal axis ..
  10. ncbi Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors
    M S Halfon
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Cell 103:63-74. 2000
    ..We demonstrate that Wingless (Wg) and Decapentaplegic (Dpp) confer competence for receptor tyrosine kinase-mediated induction of a subset of ..
  11. ncbi Components of wingless signalling in Drosophila
    E Siegfried
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115
    Nature 367:76-80. 1994
    ..One of these, wingless (wg), encodes a secreted protein that is homologous to the mammalian proto-oncogene Wnt-1 (refs 4, 5)...
  12. ncbi Notch signaling: cell fate control and signal integration in development
    S Artavanis-Tsakonas
    Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Science 284:770-6. 1999
    ..Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis...
  13. pmc Early even-skipped stripes act as morphogenetic gradients at the single cell level to establish engrailed expression
    M Fujioka
    Jefferson Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Development 121:4371-82. 1995
    ..In addition, we show that the early eve gradient is sufficient, at its posterior edge, for subdividing the ftz domain into engrailed expressing and non-expressing cells...
  14. ncbi wingless is required for the formation of a subset of muscle founder cells during Drosophila embryogenesis
    M K Baylies
    Development 121:3829-37. 1995
    ..Mutations in only one member of this class, wingless (wg), lead to the complete loss of a subset of muscle founder cells characterised by the expression of S59...
  15. ncbi Interaction between Wingless and Notch signaling pathways mediated by dishevelled
    J D Axelrod
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 271:1826-32. 1996
    ..It is proposed that Dishevelled, in addition to transducing the Wingless signal, blocks Notch signaling directly, thus providing a molecular mechanism for the inhibitory cross talk observed between these pathways...
  16. pmc Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes
    Maxim Nekrasov
    Gene Expression Programme, EMBL, Heidelberg, Germany
    EMBO J 26:4078-88. 2007
    ..Pcl-PRC2 is thus the HMTase that generates the high levels of H3-K27 trimethylation in Polycomb target genes that are needed to maintain a Polycomb-repressed chromatin state...
  17. pmc Zfh-1 controls somatic stem cell self-renewal in the Drosophila testis and nonautonomously influences germline stem cell self-renewal
    Judith L Leatherman
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Stem Cell 3:44-54. 2008
    ..In contrast, germline-intrinsic STAT activation was insufficient for GSC renewal. These data reveal unexpected complexity in cell interactions in the niche, implicating CPCs in GSC self-renewal...
  18. doi EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem cells
    Na Xu
    Department of Pediatrics Neonatology, Duke University, Durham, NC 27710, USA
    Dev Biol 354:31-43. 2011
    ..Drosophila midgut, the surrounding visceral muscle maintains intestinal stem cells (ISCs) by stimulating Wingless (Wg) and JAK/STAT pathway activities, whereas cytokine production in mature enterocytes also induces ISC division and ..
  19. ncbi wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate
    E Siegfried
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Cell 71:1167-79. 1992
    ..throughout the segment is mediated by the wingless (wg) protein, which is the homolog of the proto-oncogene Wnt-1...
  20. ncbi Evolution and role of Pax genes
    M Noll
    Institute for Molecular Biology II, University of Zurich, Switzerland
    Curr Opin Genet Dev 3:595-605. 1993
    ..Their developmental roles are assessed in terms of their participation in conserved gene networks and mechanisms that establish positional information...
  21. ncbi Expression and function of clift in the development of somatic gonadal precursors within the Drosophila mesoderm
    M Boyle
    The Rockefeller University, NYC, NY 10021 6399, USA
    Development 124:971-82. 1997
    ..position of the somatic gonadal precursor cells within a parasegment are established by the secreted growth factor Wg, coupled with a gene regulatory hierarchy within the mesoderm...
  22. ncbi PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling
    T Q Sun
    Cardiovascular Research Institute, University of California, San Francisco, California, USA
    Nat Cell Biol 3:628-36. 2001
    b>Wnt signalling regulates beta-catenin-dependent developmental processes through the Dishevelled protein (Dsh). Dsh regulates two distinct pathways, one mediated by beta-catenin and the other by Jun kinase (JNK)...
  23. ncbi The topology of the regulatory interactions predicts the expression pattern of the segment polarity genes in Drosophila melanogaster
    Reka Albert
    School of Mathematics, University of Minnesota, 127 Vincent Hall, Minneapolis, MN 55455, USA
    J Theor Biol 223:1-18. 2003
    ..The model gives important insights into the functioning of the segment polarity gene network, such as the crucial role of the wingless and sloppy paired genes, and the network's ability to correct errors in the pre-pattern...
  24. ncbi Puckered, a Drosophila MAPK phosphatase, ensures cell viability by antagonizing JNK-induced apoptosis
    Donald G McEwen
    Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Development 132:3935-46. 2005
    ..However, if cell death is prevented, JNK activation can trigger tissue overgrowth. Thus, MKPs are key regulators of the delicate balance between proliferation, differentiation and apoptosis during development...
  25. ncbi Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction
    Gary Davidson
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Nature 438:867-72. 2005
    Signalling by Wnt proteins (Wingless in Drosophila) has diverse roles during embryonic development and in adults, and is implicated in human diseases, including cancer...
  26. ncbi Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila
    Yaopan Mao
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 133:2539-51. 2006
    ..Our results implicate Dachs as a crucial downstream component of a Fat signaling pathway that influences growth, affinity and gene expression during development...
  27. pmc Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila
    Vladimir L Katanaev
    Department of Biology, TransRegio SFB11, University of Konstanz, Konstanz, Germany
    EMBO J 27:509-21. 2008
    The lipid-modified morphogens Wnt and Hedgehog diffuse poorly in isolation yet can spread over long distances in vivo, predicting existence of two distinct forms of these morphogens...
  28. ncbi Mechanisms of Wnt signaling in development
    A Wodarz
    Institut fur Genetik, Universitat Dusseldorf, Germany
    Annu Rev Cell Dev Biol 14:59-88. 1998
    b>Wnt genes encode a large family of secreted, cysteine-rich proteins that play key roles as intercellular signaling molecules in development...
  29. ncbi Developmental functions of the Distal-less/Dlx homeobox genes
    Grace Panganiban
    Department of Anatomy, University of Wisconsin, Madison, WI 53706, USA
    Development 129:4371-86. 2002
    ..We review what is known about the invertebrate and vertebrate Dll/Dlx genes and their varied roles during development. We propose revising the vertebrate nomenclature to reflect phylogenetic relationships among the Dlx genes...
  30. ncbi Wingless signaling regulates the maintenance of ovarian somatic stem cells in Drosophila
    Xiaoqing Song
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Development 130:3259-68. 2003
    ..Here we report that Wingless (Wg) signaling is also essential for SSC maintenance in the Drosophila ovary...
  31. ncbi Subcellular localization of the segment polarity protein patched suggests an interaction with the wingless reception complex in Drosophila embryos
    J Capdevila
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, Spain
    Development 120:987-98. 1994
    ..These data suggest the interaction of patched protein with elements of the reception complex of wingless, as a way to control the wingless expression...
  32. ncbi wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo
    M Peifer
    Department of Biology, University of North Carolina, Chapel Hill 27599 3280
    Development 120:369-80. 1994
    wingless/wnt-1 signaling directs cell fate during development. Genetic analysis in Drosophila identified genes that may encode components of the wingless signal transduction system...
  33. ncbi Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation
    D Doherty
    Howard Hughes Medical Institute, University of California, San Francisco, 94143 0724, USA
    Genes Dev 10:421-34. 1996
    ..We propose that Delta and Serrate function as compartment-specific signals in the wing disc, to activate Notch and induce downstream genes required for wing formation...
  34. ncbi Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF
    M van de Wetering
    Department of Immunology, University Hospital, Utrecht, The Netherlands
    Cell 88:789-99. 1997
    ..and LEF (lymphocyte enhancer binding factor) interact with beta-catenin and are hypothesized to mediate Wingless/Wnt signaling. We have cloned a maternally expressed Drosophila TCF family member, dTCF...
  35. ncbi Linking colorectal cancer to Wnt signaling
    M Bienz
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 103:311-20. 2000
  36. ncbi Dissecting the mechanisms of suppressor of hairless function
    M Furriols
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY, United Kingdom
    Dev Biol 227:520-32. 2000
    ..The wing-overgrowth phenotype is sensitive to the dose of Hairless and the phenotypes produced by coexpressing Su(H) and Hairless suggest that Hairless could form a component of this repressive complex...
  37. pmc The Drosophila Wnt, wingless, provides an essential signal for pre- and postsynaptic differentiation
    Mary Packard
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    Cell 111:319-30. 2002
    ..Members of the Wnt family are well established as morphogens, yet recently they have also been implicated in synapse maturation...
  38. ncbi Armadillo/beta-catenin-dependent Wnt signalling is required for the polarisation of epidermal cells during dorsal closure in Drosophila
    Veronique Morel
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
    Development 131:3273-83. 2004
    ..g. Flamingo, PCP Wingless signalling is not involved in DC...
  39. ncbi Drosophila glypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc
    Chun Han
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Development 132:667-79. 2005
    Drosophila Wingless (Wg) is the founding member of the Wnt family of secreted proteins. During the wing development, Wg acts as a morphogen whose concentration gradient provides positional cues for wing patterning...
  40. ncbi Evolutionarily conserved domains required for activation and repression functions of the Drosophila Hox protein Ultrabithorax
    Ella Tour
    Section in Cell and Developmental Biology, Division of Biology, University of California, San Diego, La Jolla, CA 92093, USA
    Development 132:5271-81. 2005
    ..These results suggest that the N-terminal region containing the SSYF motif has been conserved in many Hox proteins for its role in transcriptional activation...
  41. ncbi Intestinal stem cell, muscular niche and Wingless signaling
    Guonan Lin
    National Institute of Biological Sciences, Beijing, China
    Fly (Austin) 2:310-2. 2008
    ..muscles and is able to traverse through the basement membrane and reach ISCs, where it activates a canonical Wnt signaling pathway to promote ISC self-renewal...
  42. pmc Processing and phosphorylation of the Fat receptor
    Yongqiang Feng
    Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway NJ 08854, USA
    Proc Natl Acad Sci U S A 106:11989-94. 2009
    ....
  43. pmc The core protein of glypican Dally-like determines its biphasic activity in wingless morphogen signaling
    Dong Yan
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Dev Cell 17:470-81. 2009
    ..In Drosophila wing discs, Dlp represses short-range Wingless (Wg) signaling, but activates long-range Wg signaling...
  44. ncbi Wingless effects mesoderm patterning and ectoderm segmentation events via induction of its downstream target sloppy paired
    H H Lee
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Development 127:5497-508. 2000
    Inactivation of either the secreted protein Wingless (Wg) or the forkhead domain transcription factor Sloppy Paired (Slp) has been shown to produce similar effects in the developing Drosophila embryo...
  45. ncbi The patterns of wingless, decapentaplegic, and tinman position the Drosophila heart
    Wendy K Lockwood
    Department of Cell, Developmental and Neural Biology, University of Michigan, 830 N University, Ann Arbor, MI 48109 1048, USA
    Mech Dev 114:13-26. 2002
    Two secreted signaling molecules, wingless (wg) and decapentaplegic (dpp), are required to specify the heart in Drosophila...
  46. doi Growth regulation by Dpp: an essential role for Brinker and a non-essential role for graded signaling levels
    Gerald Schwank
    Institut fur Molekularbiologie, Winterthurerstr 190, CH 8057 Zurich, Switzerland
    Development 135:4003-13. 2008
    ..The Dpp-Brk system converts an inherently uneven growth program, with excessive cell proliferation in lateral regions and low proliferation in medial regions, into a spatially homogeneous profile of cell divisions throughout the disc...
  47. ncbi Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity
    M Peifer
    Department of Biology, Princeton University, New Jersey 08544 1003
    Genes Dev 4:1209-23. 1990
    ..Complete removal of extradenticle, maternally and zygotically, leads to specific alterations in segmentation, many of which result from failure to maintain the expression of the homeo domain protein engrailed...
  48. ncbi Spatial expression of the Drosophila segment polarity gene armadillo is posttranscriptionally regulated by wingless
    B Riggleman
    Department of Molecular Biology, Princeton University, New Jersey 08544
    Cell 63:549-60. 1990
    ..Two other segment polarity genes, porcupine and dishevelled, are required for this effect. We also show that arm protein is closely associated with the plasma membrane in virtually all cell types and often colocalizes with F-actin...
  49. ncbi The role of segment polarity genes during Drosophila neurogenesis
    N H Patel
    Howard Hughes Medical Institute, Department of Biochemistry, University of California Berkeley 94720
    Genes Dev 3:890-904. 1989
    ..Thus, in addition to their functions in epidermal pattern formation, at least four of the segment polarity genes (gooseberry, patched, Cell, and wingless) appear to have specific roles in the control of cell fates during neurogenesis...
  50. ncbi The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila
    M Tsuda
    Department of Biology, Tokyo Metropolitan University, Japan
    Nature 400:276-80. 1999
    Wingless (Wg) is a member of the Wnt family of growth factors, secreted proteins that control proliferation and differentiation during development...
  51. ncbi Dfrizzled-3, a new Drosophila Wnt receptor, acting as an attenuator of Wingless signaling in wingless hypomorphic mutants
    A Sato
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Development 126:4421-30. 1999
    ..Wingless signaling may thus be attenuated by Dfrizzled-3 at least in wingless hypomorphic mutants...
  52. ncbi Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity
    Nicholas S Tolwinski
    Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA
    Dev Cell 4:407-18. 2003
    Activation of the Wnt signaling cascade provides key signals during development and in disease...
  53. ncbi The hexapeptide and linker regions of the AbdA Hox protein regulate its activating and repressive functions
    Samir Merabet
    Laboratoire de Genetique et Physiologie du Developpement, IBDM, CNRS, Universite de la Mediterranee, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Dev Cell 4:761-8. 2003
    ..Our in vivo data thus reveal functions not previously anticipated from in vitro analyses for the hexapeptide motif in the regulation of Hox activity...
  54. ncbi Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells
    Carla Bänziger
    Institut fur Molekularbiologie, Universitat Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Cell 125:509-22. 2006
    Cell-cell communication via Wnt signals represents a fundamental means by which animal development and homeostasis are controlled...
  55. doi The behaviour of Drosophila adult hindgut stem cells is controlled by Wnt and Hh signalling
    Shigeo Takashima
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, California 90095, USA
    Nature 454:651-5. 2008
    ..self renewal, amplification and differentiation take place along the crypt-villus axis, and are controlled by the Wnt and hedgehog (Hh) signalling pathways...
  56. ncbi ladybird, a new component of the cardiogenic pathway in Drosophila required for diversification of heart precursors
    K Jagla
    Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, College de France, CU de Strasbourg
    Development 124:3471-9. 1997
    ..These events result in a diversification of heart cell identities within each segment...
  57. ncbi Molecular integration of inductive and mesoderm-intrinsic inputs governs even-skipped enhancer activity in a subset of pericardial and dorsal muscle progenitors
    S Knirr
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Dev Biol 238:13-26. 2001
    ..restricted signaling activities that are largely derived from the ectoderm, particularly those encoded by wingless (wg) and decapentaplegic (dpp)...
  58. ncbi Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing
    F J Diaz-Benjumea
    Differentiation Program, European Molecular Biology Laboratory, Heidelberg, Germany
    Development 121:4215-25. 1995
    ..Serrate serves as a spatially localized ligand which directs Wg expression through activation of Notch...
  59. ncbi Distinct mitogenic and cell fate specification functions of wingless in different regions of the wing
    C J Neumann
    European Molecular Biology Laboratory, Heidelberg, Germany
    Development 122:1781-9. 1996
    ..Localized expression of decapentaplegic (dpp) at the anterior-posterior and wingless (wg) at the dorsal-ventral compartment boundaries controls growth of the wing with respect to the A/P and D/V axes...
  60. ncbi Wingless repression of Drosophila frizzled 2 expression shapes the Wingless morphogen gradient in the wing
    K M Cadigan
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University Medical Center, California 94305, USA
    Cell 93:767-77. 1998
    In Drosophila wing imaginal discs, the Wingless (Wg) protein acts as a morphogen, emanating from the dorsal/ventral (D/V) boundary of the disc to directly define cell identities along the D/V axis at short and long range...
  61. pmc Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway
    Oscar Puig
    Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Genes Dev 17:2006-20. 2003
    ..Our results establish dFOXO as a key transcriptional regulator of the insulin pathway that modulates growth and proliferation...
  62. ncbi Delineation of a Fat tumor suppressor pathway
    Eunjoo Cho
    Howard Hughes Medical Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Nat Genet 38:1142-50. 2006
    ..melanogaster tumor suppressors, establish a basic framework for Fat signaling from receptor to transcription factor and implicate Warts as an integrator of multiple growth control signals...
  63. pmc Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin
    Marc Fiedler
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom
    Proc Natl Acad Sci U S A 108:1937-42. 2011
    b>Wnt/β-catenin signaling controls numerous steps in normal animal development and can also cause cancer if inappropriately activated...
  64. ncbi Organization of wing formation and induction of a wing-patterning gene at the dorsal/ventral compartment boundary
    J A Williams
    Howard Hughes Medical Institute, University of Wisconsin Madison 53706
    Nature 368:299-305. 1994
    ..The link between dorsal/ventral compartmentalization and wing formation distinguishes the development of this sheet-like appendage from that of legs and antennae...
  65. ncbi The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking
    V Martin
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, E 28049, Madrid, Spain
    Curr Biol 11:601-7. 2001
    ..In addition, we show that Ptc(SSD) preferentially accumulates in endosomes of the endocytic compartment. All these results suggest a role of the SSD of Ptc in mediating the vesicular trafficking of Ptc to regulate Smo activity...
  66. ncbi Wnt-mediated axon guidance via the Drosophila Derailed receptor
    Shingo Yoshikawa
    Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, PO Box 85800, San Diego, California 92186, USA
    Nature 422:583-8. 2003
    ..that Derailed keeps these axons out of the posterior commissure by acting as a receptor for Wnt5, a member of the Wnt family of secreted signalling molecules...
  67. ncbi Signaling by wingless in Drosophila
    J Klingensmith
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University School of Medicine, California 94305
    Dev Biol 166:396-414. 1994
    Wingless, a member of the Wnt gene family, is an essential gene for segmentation in Drosophila, and is also involved in many other patterning events. The gene encodes a secreted protein that can regulate gene expression in adjacent cells...
  68. ncbi Segmentation and specification of the Drosophila mesoderm
    N Azpiazu
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Genes Dev 10:3183-94. 1996
    ..We also show that hedgehog (hh) and wingless (wg) mediate pair-rule gene functions in the mesoderm, probably partly by acting within the mesoderm and partly by ..
  69. ncbi Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic
    J Kim
    Howard Hughes Medical Institute, University of Wisconsin, Madison 53706, USA
    Nature 388:304-8. 1997
    ..Mad also binds to Dpp-response elements in other genes. These results suggest that Dpp signalling regulates gene expression by activating Mad binding to target gene enhancers...
  70. pmc The C-terminal domain of armadillo binds to hypophosphorylated teashirt to modulate wingless signalling in Drosophila
    A Gallet
    Labororatoire de Génétique et Physiologie du Développement, UMR 9943 CNRS Université, IBDM CNRS INSERM Université de la Méditerranée, Campus de Luminy Case 907, F 13288 Marseille, Cedex 09, France
    EMBO J 18:2208-17. 1999
    b>Wnt signalling is a key pathway for tissue patterning during animal development...
  71. ncbi The combgap locus encodes a zinc-finger protein that regulates cubitus interruptus during limb development in Drosophila melanogaster
    P C Svendsen
    Department of Biochemistry and Molecular Biology, and Genes and Development Research Group, Faculty of Medicine, University of Calgary, Calgary Alberta, T2N 4N1, Canada
    Development 127:4083-93. 2000
    ..Finally, we find that the combgap protein binds to polytene chromosomes at many sites including the cubitus interruptus locus, suggesting that it could be a direct regulator of cubitus interruptus transcription...
  72. ncbi Divide and conquer: pattern formation in Drosophila embryonic epidermis
    V Hatini
    Dept Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Trends Genet 17:574-9. 2001
    ..Here, we review several recent reports that help to elucidate the regulatory principles used to control this pattern. Because organizers are conserved, the same fundamental principles might operate in other organizers...
  73. ncbi Heparan sulfate fine structure and specificity of proteoglycan functions
    Hiroshi Nakato
    Department of Molecular and Cellular Biology, and Arizona Cancer Center, University of Arizona, Tucson 85724, USA
    Biochim Biophys Acta 1573:312-8. 2002
    ..In this review, we focus on the molecular basis of growth factor control by the sulfation status of heparan sulfate...
  74. pmc Mutations in Su(var)205 and Su(var)3-7 suppress P-element-dependent silencing in Drosophila melanogaster
    Daniel Bushey
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada
    Genetics 168:1395-411. 2004
    ..Studying w(+) variegation from P[lacW]ci(Dplac) provides a model for the interactions that can enhance heterochromatic silencing at single P-element inserts...
  75. ncbi Serrate-Notch signaling defines the scope of the initial denticle field by modulating EGFR activation
    James W Walters
    Weill Graduate School of Medical Sciences, New York, NY 10021, USA
    Dev Biol 286:415-26. 2005
    ..This establishes one important role for the Serrate signaling territory, which is to define the extent of denticle field specification...
  76. ncbi The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless
    F Rijsewijk
    Cell 50:649-57. 1987
    ..We show that Dint-1 and the segment polarity gene wingless are identical and map to the same location. The sequence of the gene suggests that the Dint-1/wingless protein functions in morphogenesis as a signal in cell-cell communication...
  77. ncbi The development of crustacean limbs and the evolution of arthropods
    G Panganiban
    Laboratory of Molecular Biology, University of Wisconsin, Madison 53706, USA
    Science 270:1363-6. 1995
    ..However, differences between crustacean and insect body plans were found to correlate with differences in the deployment of particular homeotic genes and in the ways that these genes regulate limb development...
  78. ncbi Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing
    C J Neumann
    European Molecular Biology Laboratory, Heidelberg, Germany
    Development 124:871-80. 1997
    ..The secreted signaling molecule Wingless (Wg) is expressed by cells at the DV compartment boundary and has been implicated in mediating its long-range patterning ..
  79. ncbi A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling
    K Hofmann
    Bioinformatics and Gene Discovery Group, MEMOREC Stoffel GmbH, Stöckheimer Weg 1, D 50829 Köln, Germany
    Trends Biochem Sci 25:111-2. 2000
  80. ncbi Regulation of cell proliferation by a morphogen gradient
    Dragana Rogulja
    Howard Hughes Medical Institute, USA
    Cell 123:449-61. 2005
    ..Conversely, uniform activation of the DPP pathway inhibits cell proliferation in medial wing cells. Our observations provide a direct demonstration that the slope of a morphogen gradient regulates growth during development...
  81. ncbi The role of the Distal-less gene in the development and evolution of insect limbs
    G Panganiban
    Howard Hughes Medical Institute, University of Wisconsin Madison 53706
    Curr Biol 4:671-5. 1994
    ..Comparative studies of the expression and regulation during development of limb-patterning genes, such as Distal-less (Dll), may provide insights into arthropod evolution...
  82. ncbi Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos
    A Bejsovec
    Department of Molecular Biology, Princeton University, New Jersey 08544
    Development 119:501-17. 1993
    ....
  83. ncbi Segmental patterning of heart precursors in Drosophila
    P A Lawrence
    Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK
    Development 121:4303-8. 1995
    ..We conclude that the mesoderm is segmented in some way not dependent on the distribution of Wingless, suggesting a more permissive and less instructive role for the protein in this instance...
  84. ncbi A new member of the frizzled family from Drosophila functions as a Wingless receptor
    P Bhanot
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 382:225-30. 1996
    Receptors for Wingless and other signalling molecules of the Wnt gene family have yet to be identified...
  85. ncbi Compartment boundaries: where, why and how?
    J P Vincent
    National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom
    Int J Dev Biol 42:311-5. 1998
    ..Here, I review the work that demonstrated the existence of compartments. I then conjecture on why compartments exist and review the roles of various gene products in the maintenance of compartment boundaries...
  86. ncbi Regeneration in insects
    J L Marsh
    Developmental Biology Center and Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA
    Semin Cell Dev Biol 10:365-75. 1999
    ..Each of the regulatory networks could themselves serve as the subject of a detailed review and that is beyond the scope of this discussion. Here we will focus on the interplay between the regulatory networks in patterning the tissue...
  87. ncbi Regulated endocytic routing modulates wingless signaling in Drosophila embryos
    L Dubois
    National Institute for Medical Research, The Ridgeway, Mill Hill, NW7 1AA London, United Kingdom
    Cell 105:613-24. 2001
    ....
  88. ncbi The JAK/STAT pathway and Drosophila development
    H Luo
    The Cardiovascular Research Institute, Division of Molecular Cardiology, The Texas A and M University System Health Science Center, College of Medicine, Temple, Texas 76504, USA
    Bioessays 23:1138-47. 2001
    ..Hence, the JAK/STAT pathway in Drosophila serves as an attractive model for in vivo functional analyses of JAK/STAT signaling...
  89. ncbi Targeted increase in shaggy activity levels blocks wingless signaling
    Marc Bourouis
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Strasbourg, France
    Genesis 34:99-102. 2002
  90. pmc A nuclear function for armadillo/beta-catenin
    Nicholas S Tolwinski
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
    PLoS Biol 2:E95. 2004
    The Wnt signaling pathway provides key information during development of vertebrates and invertebrates, and mutations in this pathway lead to various forms of cancer...
  91. ncbi Influence of Notch on dorsoventral compartmentalization and actin organization in the Drosophila wing
    Robert J Major
    Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 132:3823-33. 2005
    ....
  92. ncbi Association of tracheal placodes with leg primordia in Drosophila and implications for the origin of insect tracheal systems
    Xavier Franch-Marro
    Institut de Biologia Molecular de Barcelona, CSIC, Barcelona, C Josep Samitier 1 5, 08028 Barcelona, Spain
    Development 133:785-90. 2006
    ..We propose an evolutionary scenario that accommodates the available data...
  93. ncbi The segment polarity gene armadillo interacts with the wingless signaling pathway in both embryonic and adult pattern formation
    M Peifer
    Department of Molecular Biology, Princeton University, New Jersey 08544 1014
    Development 111:1029-43. 1991
    ..We present a description of the patterns of arm protein accumulation in imaginal discs. Finally, we discuss the implications of these results for the role of arm and wingless in pattern formation...
  94. pmc Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila
    J Mohler
    Department of Biological Sciences, Barnard College, New York, New York 10027
    Genetics 120:1061-72. 1988
    ..Because the defects are associated with homozygous clones, but are not co-extensive, a type of "domineering" nonautonomy is proposed for the activity of the hedgehog gene...
  95. ncbi Wingless and patched are negative regulators of the morphogenetic furrow and can affect tissue polarity in the developing Drosophila compound eye
    C Ma
    Department of Biological Sciences, University of Southern California, Los Angeles 90089 1340, USA
    Development 121:2279-89. 1995
    ..We use such patched induced furrows to test the two-vector model for cluster rotation and tissue polarity...
  96. ncbi Cell interaction between compartments establishes the proximal-distal axis of Drosophila legs
    F J Diaz-Benjumea
    Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Nature 372:175-9. 1994
    ..expression of hedgehog (hh) in the posterior compartment of the leg imaginal disc directs expression of wingless (wg) in ventral-anterior cells and decapentaplegic (dpp) in dorsal-anterior cells near the anterior-posterior ..
  97. ncbi Autoproteolysis in hedgehog protein biogenesis
    J J Lee
    Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, Baltimore, MD 21205
    Science 266:1528-37. 1994
    ..The two HH protein species exhibited distinctive biochemical properties and tissue distribution, and these differences suggest a mechanism that could account for the long- and short-range signaling activities of HH in vivo...
  98. ncbi Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells
    F van Leeuwen
    Howard Hughes Medical Institute, Beckman Center, Stanford University, School of Medicine, California 94305
    Nature 368:342-4. 1994
    The phenotypes caused by mutations in Wnt genes suggest that their gene products are involved in cell-to-cell communication. Wnt genes indeed encode secreted molecules, but soluble active Wnt protein has not been found...
  99. ncbi Pattern formation in a secondary field: a hierarchy of regulatory genes subdivides the developing Drosophila wing disc into discrete subregions
    J A Williams
    Howard Hughes Medical Institute, University of Wisconsin Madison 53706
    Development 117:571-84. 1993
    ....
  100. ncbi In vivo requirement for the paired domain and homeodomain of the paired segmentation gene product
    C Bertuccioli
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Development 122:2673-85. 1996
    ....
  101. ncbi A hierarchy of cross-regulation involving Notch, wingless, vestigial and cut organizes the dorsal/ventral axis of the Drosophila wing
    C J Neumann
    European Molecular Biology Laboratory, Heidelberg, Germany
    Development 122:3477-85. 1996
    ..These results suggest that secreted Wingless protein mediates both long-range and short-range patterning activities of the dorsal/ventral boundary...

Research Grants60

  1. TISSUE SPECIFICITY OF WINGLESS SIGNALING IN DROSOPHILA
    Kenneth Cadigan; Fiscal Year: 2005
    ..In addition, Wnt signaling has been implicated in tumorigenesis in mice and humans...
  2. Wnt and beta-Catenin Signaling in Development/Disease
    Mariann Bienz; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): The Wnt/[unreadable]-catenin pathway is a highly conserved signaling cascade that plays key roles during animal development...
  3. GENETIC CONTROL OF CELL FATE DIVERSITY IN DROSOPHILA
    Amy Bejsovec; Fiscal Year: 2003
    ..Wg and its vertebrate Wnt homologues are essential for generating pattern in both invertebrate and vertebrate embryos...
  4. Identification of new Wnt signaling components
    Kenneth Cadigan; Fiscal Year: 2006
    ..An important example of this is found in the Wnt signaling pathway...
  5. Analysis of fringe-dependent cell-signaling
    Kenneth Irvine; Fiscal Year: 2004
    ....
  6. CONFOCAL MICROSCOPE FOR LIVE CELL & MULTIWAVELENGTH WORK
    Mark Peifer; Fiscal Year: 2001
    ..Our proposal seeks to meet these new needs, by the creation of a multi-user facility that will provide a state-of-the art confocal microscope to a large group of NIH funded investigators. ..
  7. Identification of extrinsic signals in blood formation
    Jan Christian; Fiscal Year: 2006
    ..Understanding how normal blood development occurs is crucial to understanding and preventing disease resulting from misregulation of these pathways. ..
  8. BH3-only protein BNIP3 in tumor progression
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2006
    ..Our results may also provide the experimental support to suggest that BNIP3 may be a new prognostic marker for human cancer. [unreadable] [unreadable]..
  9. Viral Immunity in Drosophila
    Norbert Perrimon; Fiscal Year: 2007
    ..Because our insect virus system is sensitive to drugs that are used against human viruses, our studies may lead to the identification of novel antiviral compounds that may prove effective in mammalian cells. ..
  10. Organogenesis Screen Using Tissue-Specific Zebrafish
    Jau Nian Chen; Fiscal Year: 2005
    ..Mutations identified from this screen will provide entry points to dissect genetic and molecular pathways involved in vertebrate organogenesis. ..
  11. Molecular Genetics of Drosophila MAGUK's
    Peter Bryant; Fiscal Year: 2005
    ..The work will provide a genetic approach to understanding the functions of Dlg and its mammalian homologs, some of which are strongly implicated in a variety of human cancers. ..
  12. Cytoskeleton Coordination in Neuronal Morphogenesis
    W Nelson; Fiscal Year: 2005
    ..for degradation thereby regulating another function of beta-catenin in controlling gene expression in response to Wnt signaling...
  13. Apoptosis Signaling: BH3 to BH123 Proteins
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2008
    ..The knowledge gained would be valuable in modulating the activity of BAX in cancer and in degenerative diseases. ..
  14. GORDON RESEARCH CONFERENCE ON PROTEOGLYCANS
    ARTHUR LANDER; Fiscal Year: 2002
    ....
  15. The Role of Beta-catenin/Tcf Pathway Defects in Cancer
    Eric Fearon; Fiscal Year: 2009
    ..The "canonical" Wnt pathway is arguably the best characterized of the Wnt-dependent pathways uncovered, and mutations in key factors in ..
  16. Regulation of Cell Migration by the APC-Microtubule Complex
    William Nelson; Fiscal Year: 2009
    ..abstract_text> ..
  17. TRANSCRIPTIONAL COACTIVATORS IN ENDOCRINE REGULATION
    Richard Goodman; Fiscal Year: 2003
    ..Finally, we will characterize the ability of the "CREB binding domain" of CBP to interact with other transcription factors activated or inhibited by Ser/Thr phosphorylation. ..
  18. TRAINING PROGRAM IN CELLULAR AND MOLECULAR NEUROSCIENCE
    ARTHUR LANDER; Fiscal Year: 2007
    ..Following completion of this program, trainees will be qualified for careers in Neuroscience research and/or teaching in basic science departments and medical schools, or for research careers in non-academic research laboratories. ..
  19. Mechanisms Regulating Myoblast Fusion in Drosophila
    Mary K Baylies; Fiscal Year: 2010
    ....
  20. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    GERARD L CAMPBELL; Fiscal Year: 2010
    ..Consequently, the proposed studies should provide insights into diseases such as these, potentially leading to improved diagnosis and treatment. ..
  21. Molecular and genetic analysis of sanpodo
    James B Skeath; Fiscal Year: 2010
    ..Such insight should help us understand the etiology of diseases in which this process is de-regulated and design new methods to treat these diseases. ..
  22. Patterning of the Primitive Heart Tube in Zebrafish
    Jau Nian Chen; Fiscal Year: 2010
    ..The combination of cellular, molecular and genetic studies proposed in this project will provide new and in-depth insight into mechanisms of primitive heart tube morphogenesis. ..
  23. High-throughput screening assay development for axonopathic neurodegeration
    Norbert Perrimon; Fiscal Year: 2006
    ..The long term goal of this work is thus to understand better the causes of axonal destruction in neurodegenerative diseases, and to find drugs that can slow or prevent axonal degeneration from occurring. ..
  24. Regulation of MeCP2 by CREB-induced microRNAs
    Richard H Goodman; Fiscal Year: 2010
    ..The studies described in this proposal address a completely novel mechanism of gene regulation that has implications for the understanding of MeCP2 biology and neural development in general. ..
  25. Analysis of BMP-4 activity in Cleavage mutant mice
    Jan Christian; Fiscal Year: 2007
    ..Understanding the molecular mechanisms by which BMP activity is regulated is key to understanding, treating and preventing congenital anomalies and diseases. [unreadable] [unreadable]..
  26. Identification of gene targets for morphine and other drugs of abuse
    Richard Goodman; Fiscal Year: 2009
    ..The concept that CREB signaling induces mediators of translational arrest has profound implications for the understanding of drug action. ..
  27. Feedback Regulation of Wnt signaling
    KEITH WHARTON; Fiscal Year: 2007
    ..Secreted Wnt proteins initiate intercellular signal transduction cascades that regulate cell morphology, execute cell fate ..
  28. A novel Dlg isoform and identification of its interacting proteins
    Kyung Ok Cho; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  29. Mechanism of Hedgehog signal transduction
    JOAN HOOPER; Fiscal Year: 2007
    ..Their successful completion would significantly advance our understanding of this fundamental signal transduction pathway and may pinpoint therapeutic targets for Hh-based pathologies. [unreadable] [unreadable] [unreadable]..
  30. CELL FATE DETERMINATION IN THE MESODERM OF DROSOPHILA
    Mary Baylies; Fiscal Year: 2008
    ..Our work in Drosophila on the mechanisms and targets of these regulators' action will provide insight as to the underlying causes of these diseases and will help to reveal potential therapies. ..
  31. Mechanisms of Wound Healing in Drosphila
    Susan Parkhurst; Fiscal Year: 2009
    ..Controlling repair and inflammation will also be a fundamental consideration in tissue engineering where artificial and/or cell based constructs are implanted to reconstruct tissues. ..
  32. Regulatory Genomics: BAC-GFP Library of Control Genes
    Eric Davidson; Fiscal Year: 2008
    ..Numerous letters from outside investigators attesting interest in this facility are included as an Appendix to this application. ..
  33. Network Topology in Cell Signaling
    Norbert Perrimon; Fiscal Year: 2008
    ..Altogether, these studies will greatly advance our knowledge of signaling networks and their organization during signal transduction. [unreadable] [unreadable] [unreadable]..
  34. Transcriptional Repression and Cofactor Recruitment
    Susan Parkhurst; Fiscal Year: 2008
    ..Results obtained from these projects are expected to have wide implications as HES family proteins and mechanisms of transcriptional repression are conserved throughout organisms. ..
  35. Host factors involved in bacterial pathogenesis
    Norbert Perrimon; Fiscal Year: 2009
    ..tuberculosis and its human host. ..
  36. CONTROL OF TGF-BETA SIGNALING IN DROSOPHILA BY BRINKER
    Gerard Campbell; Fiscal Year: 2004
    ..Consequently, the present research should have direct relevance to our understanding of how defects in TGF-B signaling can lead to disease. ..
  37. IN VIVO ROLE OF PROTEOGLYCANS IN GROWTH FACTOR SIGNALING
    J Marsh; Fiscal Year: 2001
    ..The involvement of proteoglycans in Wnt and possibly other growth factor signaling pathways adds a new dimension to the mechanism of signal transmission ..
  38. SYNAPSE STRUCTURE AND DEVELOPMENT
    W Nelson; Fiscal Year: 2001
    ..This research will aid in the prevention of psychiatric illness and the development of therapies for afflicted individuals. ..
  39. Conference on Wnt and Beta Catenin Signaling
    Randall Moon; Fiscal Year: 2002
    ..The Wnt signaling pathway that activates B-catenin exemplifies this principle...
  40. SPECTRAL CONFOCAL MICROSCOPE
    Peter Bryant; Fiscal Year: 2002
    ..abstract_text> ..
  41. MOLECULAR MECHANISM OF WINGLESS SIGNALING
    Susan Cumberledge; Fiscal Year: 2002
    ..The proteins encoded by the Drosophila gene wingless (wg) and its vertebrate ortholog Wnt-1 are two such signals. The wg/Wnt-1 pathway regulates both differentiation and cell proliferation...
  42. Signaling Mechanisms of the Drosophila JAK/STAT Pathway
    Hong Luo; Fiscal Year: 2003
    ..abstract_text> ..
  43. 2003 Gordon Research Conference - Biology of Aging
    John Tower; Fiscal Year: 2003
    ..Significant funding is also provided by the Gordon Research Conference Organization, and additional funds are being solicited from private foundations and industry. ..
  44. DROSOPHILA LONGEVITY ASSURANCE GENES
    John Tower; Fiscal Year: 2003
    ..PdL creates dominant conditional mutations, which should greatly facilitate the identification, characterization and cloning of novel Drosophila LAGs. ..
  45. ROLES OF HEPARAN SULFATE PROTEOGLYCANS IN SIGNALING
    Norbert Perrimon; Fiscal Year: 2003
    ..mutations in enzymes that generate or modify the GAG chains, exhibit phenotypes reminiscent of loss of Wingless (Wg), Fibroblast Growth Factor (FGF) and/or Hedgehog (Hh) activities...
  46. Computational and Functional Analysis of Gene Networks
    MARC HALFON; Fiscal Year: 2006
    ..abstract_text> ..
  47. PROTEOGLYCANS AND BRAIN DEVELOPMENT
    ARTHUR LANDER; Fiscal Year: 2004
    ..These studies should provide insights into how an important and poorly understood class of molecules regulates basic developmental processes, particularly in the nervous system. ..
  48. REGULATORS OF MUSCLE DIFFERENTIATION
    Hanh Nguyen; Fiscal Year: 2004
    ..Some of the principles arising from studies in the muscle system may also be applicable to other developmental systems, and thus will potentially contribute to our understanding of other developmental defects in humans. ..
  49. Transport and Complexity in Biological Systems
    ARTHUR LANDER; Fiscal Year: 2004
    ..abstract_text> ..
  50. Drosophila DNA Replication Origins
    John Tower; Fiscal Year: 2005
    ..The experiments will test a number of specific hypotheses as to the organization and regulation of the chorion locus DNA replication origins. ..
  51. High-throughput screen:Listeria infection (RMI)
    Norbert Perrimon; Fiscal Year: 2004
    ....
  52. Conference on Cell Polarity & Asymmetric Cell Divisions
    Norbert Perrimon; Fiscal Year: 2004
    ..The goal of the meeting is to bring together the leading experts that study the mechanism of cell polarization and cell asymmetry to discuss emerging concepts. ..
  53. MOLECULAR BASIS OF DEVELOPMENTAL CELL INTERACTIONS
    J Marsh; Fiscal Year: 2005
    ..Studies during the last period of this project reveal that two key morphogens, wg and dpp, form a self organizing system by suppressing each other's expression and perhaps by autoactivating their ..
  54. Mechanisms of Rho GTPase Function in Drosophila
    Susan Parkhurst; Fiscal Year: 2006
    ..Our results are expected to have wide implications as Rho GTPases and the diverse cellular mechanisms they mediate are conserved across a wide range of organisms. ..
  55. RECEPTORS AND SIGNALING IN NEUROENDOCRINE SYSTEMS
    Richard Goodman; Fiscal Year: 2006
    ..Core laboratories for cell culture, protein chemistry, and administration are designed to allow the proposed studies to be performed in an efficient and cost-effective manner. ..
  56. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    Susan Parkhurst; Fiscal Year: 2002
    ..Results obtained from these projects are expected to have wide implications as Hairy/E(spl) proteins and mechanisms of transcriptional repression are conserved throughout organisms. ..