Genomes and Genes
Gene Symbol: unc-5
Description: CG8166 gene product from transcript CG8166-RB
Alias: AAF7419, CG8166, CG8168, CT20824, Dmel\CG8166, Dunc5, UNC-5, UNC5, UNC5D, Unc-5, Unc5, Unc5d, dUnc5, unc5, CG8166 gene product from transcript CG8166-RB, CG8166-PA, CG8166-PB, UNC5 protein, Uncoordinated5, unc-5-PA, unc-5-PB, unc-5-like, uncoordinated 5
Species: fruit fly
- The homeobox transcription factor even-skipped regulates netrin-receptor expression to control dorsal motor-axon projections in DrosophilaJuan Pablo Labrador
Department of Neuroscience, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
Curr Biol 15:1413-9. 2005..Our results support a functional link between the expression of distinct Netrin receptor combinations and the transcriptional control of dorsal motor-axon guidance...
- The transmembrane receptor Uncoordinated5 (Unc5) is essential for heart lumen formation in Drosophila melanogasterStefanie Albrecht
Universitat Osnabruck, Fachbereich Biologie Chemie Zoologie Entwicklungsbiologie, Barbarastraße 11, 49069 Osnabruck, Germany
Dev Biol 350:89-100. 2011..In this study we show the requirement for the repulsively active Unc5 transmembrane receptor to facilitate tubulogenesis in the dorsal vessel of Drosophila...
- Golden Goal collaborates with Flamingo in conferring synaptic-layer specificity in the visual systemSatoko Hakeda-Suzuki
Max Planck Institute of Neurobiology, Martinsried, Germany
Nat Neurosci 14:314-23. 2011..We propose that Gogo acts as a functional partner of Fmi for R8 photoreceptor axon targeting and that the dynamic regulation of their interaction specifies synaptic-layer selection of photoreceptors...
- Short- and long-range repulsion by the Drosophila Unc5 netrin receptorK Keleman
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Neuron 32:605-17. 2001..They act through receptors of the DCC and UNC5 families. DCC receptors have been implicated in both attraction and repulsion by Netrins...
- Crossing the border: molecular control of motor axon exitArlene Bravo-Ambrosio
Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Int J Mol Sci 12:8539-61. 2011..Here, we describe the small set of studies that have addressed motor axon exit in Drosophila and vertebrates, and discuss our fragmentary knowledge of the mechanisms, which guide motor axons out of the CNS...
- Equivalent Activities of Repulsive Axon Guidance ReceptorsHong Long
Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037
J Neurosci 36:1140-50. 2016..chimeras using the extracellular and intracellular domains of three different Drosophila repulsive receptors, Unc5, Roundabout (Robo), and Derailed (Drl) and expressing them in defined cells within the embryonic nervous system, we ..
- A subset of interneurons required for Drosophila larval locomotionShingo Yoshikawa
Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, United States
Mol Cell Neurosci 70:22-9. 2016..Identification of the LLNs represents the first step toward elucidating the circuit generating larval locomotion. ..
- The Unc-5 Receptor Is Directly Regulated by Tinman in the Developing Drosophila Dorsal VesselJamshid Asadzadeh
Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
PLoS ONE 10:e0137688. 2015..We show that Tin can bind to evolutionary conserved sites within an Unc-5 DV enhancer and that these sites are required for Tin-dependent transactivation both in vitro and in vivo. ..
- A migrating ciliary gate compartmentalizes the site of axoneme assembly in Drosophila spermatidsMarcus L Basiri
Department of Biological Sciences, University of Toledo, 3050 W Towerview Boulevard, Toledo, OH 43606, USA
Curr Biol 24:2622-31. 2014..The transition zone is closely associated with multiple structures of the ciliary base, including the centriole, axoneme, and ciliary membrane. However, the contribution of these structures to the ciliary gate remains unclear...
- Cdc42 and formin activity control non-muscle myosin dynamics during Drosophila heart morphogenesisGeorg Vogler
Development, Aging and Regeneration Program, Sanford Burnham Medical Research Institute, La Jolla, CA 92037
J Cell Biol 206:909-22. 2014..Placement of Slit at the lumen surface depends on Cdc42 and formin function. Thus, Cdc42 and formins play pivotal roles in heart lumen formation through the spatiotemporal regulation of the actomyosin network. ..
- Enhancer loops appear stable during development and are associated with paused polymeraseYad Ghavi-Helm
European Molecular Biology Laboratory, Genome Biology Unit, D 69117 Heidelberg, Germany
Nature 512:96-100. 2014..Our results indicate that the general topology governing enhancer contacts is conserved from flies to humans and suggest that transcription initiates from preformed enhancer-promoter loops through release of paused polymerase. ..
- Collective cell migration: "all for one and one for all"Tripti Gupta
Institut de Genetique et de Biologie Moleculaire et Cellulaire, IGBMC CNRS INSERM UDS, Illkirch Graffenstaden, France
J Neurogenet 28:190-8. 2014..This review impinges upon the cellular and molecular interactions underlying collective cell migration in animal models, and highlights the recent advances made through in vivo analyses of the Drosophila wing glia...
- A transcription factor network coordinates attraction, repulsion, and adhesion combinatorially to control motor axon pathway selectionAref Arzan Zarin
Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
Neuron 81:1297-311. 2014..Finally, we show that a network of TFs, comprised of eve, zfh1, and grain, induces the expression of the Unc5 and Beaten-path guidance receptors and the Fasciclin 2 and Neuroglian adhesion molecules to guide individual dMN ..
- Assessing the role of cell-surface molecules in central synaptogenesis in the Drosophila visual systemSandra Berger-Müller
Research Group Axon Guidance and Neuronal Connectivity, Max Planck Institute of Neurobiology, Martinsried, Germany CNRS 5273, Unité mixte de recherche STROMALab, Toulouse, France
PLoS ONE 8:e83732. 2013....
- Interactions between a receptor tyrosine phosphatase and a cell surface ligand regulate axon guidance and glial-neuronal communicationHyung Kook Peter Lee
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Neuron 78:813-26. 2013..We find that neuronal Ptp10D restrains signaling by overexpressed glial Sas, which would otherwise produce strong glial and axonal phenotypes...
- Frazzled/DCC facilitates cardiac cell outgrowth and attachment during Drosophila dorsal vessel formationFrank D Macabenta
Department of Pathology and Laboratory Medicine Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854, USA
Dev Biol 380:233-42. 2013..Previous studies have shown that the Slit/Roundabout and Netrin/Unc5 repulsive signaling pathways facilitate site-specific loss of adhesion between contralateral CBs in order to form a ..
- Src inhibits midline axon crossing independent of Frazzled/Deleted in Colorectal Carcinoma (DCC) receptor tyrosine phosphorylationMichael P O'Donnell
Cell and Molecular Biology Graduate Group and Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Neurosci 33:305-14. 2013..We propose that distinct signaling outputs must exist for midline axon crossing independent of Src kinases in commissural neurons...
- A GATA/homeodomain transcriptional code regulates axon guidance through the Unc-5 receptorAref Arzan Zarin
Smurfit Institute of Genetics, Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
Development 139:1798-805. 2012..Taken together, our data strongly suggests that the eve-grn transcriptional code controls axon guidance, in part, by regulating the level of unc-5 expression...
- Netrins guide migration of distinct glial cells in the Drosophila embryoChristian M von Hilchen
Institute of Genetics, University of Mainz, Saarstrasse 21, Mainz, Germany
Development 137:1251-62. 2010..Later in development, most ePG transiently express uncoordinated 5 (unc5) during their migratory phase...
- Netrins guide Drosophila commissural axons at short rangeMarko Brankatschk
Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5, A 1030 Vienna, Austria
Nat Neurosci 9:188-94. 2006..We therefore propose that netrins act in commissural axon guidance as short-range cues that promote midline crossing, not as long-range chemoattractants...
- Positional cues in the Drosophila nerve cord: semaphorins pattern the dorso-ventral axisMarta Zlatic
Department of Zoology, University of Cambridge, Cambridge, United Kingdom
PLoS Biol 7:e1000135. 2009..Together our findings support the idea that axons are delivered to particular regions of the neuropile by their responses to systems of positional cues in each dimension...
- Cytoplasmic domain requirements for Frazzled-mediated attractive axon turning at the Drosophila midlineDavid S Garbe
Department of Neuroscience, University of Pennsylvania School of Medicine, 1113 BRB2 3, 421 Curie Blvd, Philadelphia, PA 19104, USA
Development 134:4325-34. 2007....
- A sensory feedback circuit coordinates muscle activity in DrosophilaCynthia L Hughes
Molecular Neurobiology Laboratory, The Salk Institute, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
Mol Cell Neurosci 35:383-96. 2007....
- NETRIN and SLIT guide salivary gland migrationTereza Kolesnikov
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
Dev Biol 284:102-11. 2005..We propose that analogous to axon guidance, a balance between chemo-attractants and chemo-repellents is required for the proper migratory path of the developing salivary glands...
- Neurons and glia: team players in axon guidanceCarole Chotard
National Institute for Medical Research, Division of Molecular Neurobiology, The Ridgeway, London NW7 1AA, UK
Trends Neurosci 27:655-61. 2004..Equally, neurons provide crucial information to glia, supporting their migration and correct positioning...
- robo2 and robo3 interact with eagle to regulate serotonergic neuron differentiationJessica A Couch
Department of Biology, 071 Gilmer Hall, University of Virginia, Charlottesville, VA 22903, USA
Development 131:997-1006. 2004..We propose that post-midline expression of Robo2/3 is part of a signal that regulates serotonergic neuron differentiation and is transduced by the transcription factor Eg...
- Specification of neuropeptide cell identity by the integration of retrograde BMP signaling and a combinatorial transcription factor codeDouglas W Allan
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
Cell 113:73-86. 2003..Thus, an intrinsic transcription factor code integrates with an extrinsic retrograde signal to select a specific neuropeptide identity within peptidergic cells...
- MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsionJonathan R Terman
Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
Cell 109:887-900. 2002..These results suggest a novel role for oxidoreductases in repulsive neuronal guidance...