Uba1

Summary

Gene Symbol: Uba1
Description: Ubiquitin activating enzyme 1
Alias: 2/31, CG1782, DmUba1, Dmel\CG1782, FBtr0088499, UBA-1, Uba 1, l(2)03405, l(2)05642, l(2)s3484, uba-1, uba1, CG1782 gene product from transcript CG1782-RA, CG1782-PA, CG1782-PC, E1 ligase, Uba1-PA, Uba1-PC, ubiquitin activating enzyme, ubiquitin activating enzyme 1, ubiquitin-activating enzyme (E1)
Species: fruit fly

Top Publications

  1. ncbi Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis
    John P Wing
    Biology Department, University of Massachusetts at Amherst, Amherst, MA 01003, USA
    Nat Cell Biol 4:451-6. 2002
  2. pmc Impairment of ubiquitylation by mutation in Drosophila E1 promotes both cell-autonomous and non-cell-autonomous Ras-ERK activation in vivo
    Hua Yan
    Department of Oncological Sciences, The Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Sci 122:1461-70. 2009
  3. pmc The E1 ubiquitin-activating enzyme Uba1 in Drosophila controls apoptosis autonomously and tissue growth non-autonomously
    Tom V Lee
    The University of Texas M D Anderson Cancer Center, Department of Biochemistry and Molecular Biology, Houston, TX 77030, USA
    Development 135:43-52. 2008
  4. ncbi Axon pruning during Drosophila metamorphosis: evidence for local degeneration and requirement of the ubiquitin-proteasome system
    Ryan J Watts
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Neuron 38:871-85. 2003
  5. ncbi The ubiquitin proteasome system acutely regulates presynaptic protein turnover and synaptic efficacy
    Sean D Speese
    Department of Biology, 257 South 1400 East, University of Utah, Salt Lake City, UT 84112 0840, USA
    Curr Biol 13:899-910. 2003
  6. ncbi Mutation of the gene encoding the ubiquitin activating enzyme ubal causes tissue overgrowth in Drosophila
    Cathie M Pfleger
    Massachusetts General Hospital Canter Center, Massachusetts General Hospital, Chrlestown, Massachusetts, USA
    Fly (Austin) 1:95-105. 2007
  7. pmc Screening of suppressors of bax-induced cell death identifies glycerophosphate oxidase-1 as a mediator of debcl-induced apoptosis in Drosophila
    Jessie Colin
    Universite Versailles St Quentin, Laboratoire de Genetique et Biologie Cellulaire, Montigny le Bretonneux, France École Pratique des Hautes Études, Laboratoire de génétique moléculaire et physiologique, Montigny le Bretonneux, France
    Genes Cancer 6:241-53. 2015
  8. doi The drosophila Bcl-2 family protein Debcl is targeted to the proteasome by the β-TrCP homologue slimb
    Jessie Colin
    Laboratoire de Genetique et Biologie Cellulaire, EA4589, Universite de Versailles Saint Quentin en Yvelines, Ecole Pratique des Hautes Etudes, Bâtiment Simone Veil, 2 avenue de la Source de la Bièvre, 78180, Montigny le Bretonneux, France
    Apoptosis 19:1444-56. 2014
  9. pmc Synergistic effects on dopamine cell death in a Drosophila model of chronic toxin exposure
    Ciara A Martin
    UCLA Interdepartmental Program in Molecular Toxicology, Los Angeles, CA 90095, United States Electronic address
    Neurotoxicology 44:344-51. 2014
  10. pmc Multiple mechanisms modulate distinct cellular susceptibilities toward apoptosis in the developing Drosophila eye
    Yun Fan
    Department of Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA Electronic address
    Dev Cell 30:48-60. 2014

Scientific Experts

  • Yun Fan
  • David B Kantor
  • Andrea Page-McCaw
  • Jessie Colin
  • Tom V Lee
  • Cathie M Pfleger
  • Andreas Bergmann
  • Hua Yan
  • Amandine Clavier
  • Julie Garibal
  • Isabelle Guenal
  • Bernard Mignotte
  • Sebastien Gaumer
  • Ciara A Martin
  • Song Li
  • Hsiu Yu Liu
  • Tsun Kai Chang
  • A E Christiansen
  • Peter Smibert
  • Fan Li
  • Kiriaki Kanakousaki
  • Shuang Li
  • Cristinel Sandu
  • Dongbin Xu
  • Oren Schuldiner
  • Morwena Latouche
  • Liqun Luo
  • Kenji Nakahara
  • Chay T Kuo
  • Laura Korhonen
  • Sean D Speese
  • Su Wan Oh
  • Ryan J Watts
  • Yanick Risler
  • Cécile Milet
  • Sébastien Szuplewski
  • Cheng Wang
  • David E Krantz
  • Carol Tang
  • John P Wing
  • Hongyan Wang
  • Yosephine P Lumintang
  • Khadij Assani
  • Angel Barajas
  • Beng T Ang
  • Sherry S Y Aw
  • Jack J L Wong
  • Aurore Rincheval-Arnold
  • Edwin Sandanaraj
  • Hakeem O Lawal
  • Vanessa Núñez
  • Fengwei Yu
  • Chwee T Koe
  • Hsin Pei Shih
  • George Lawless
  • H K Graves
  • Jr Shiuan Yang
  • Ji Long Liu
  • Bhupendra V Shravage
  • Ghows Azzam
  • Rachel T Simin
  • Eric C Lai
  • J Wade Harper
  • Sebastian D Hayes
  • T Ding
  • Christine M Powers
  • J L Lindblad
  • Eric H Baehrecke
  • H M Herz
  • A Bergmann
  • Tao Yue
  • Subhadra Aiyer
  • Jamie Yang
  • Paul Ryvkin
  • Jin Jiang
  • Bing Wang
  • Todd Lamitina
  • Li San Wang
  • Qing Shi
  • Otto Valladares
  • Arjun Raj
  • Leah R Sabin
  • John I Murray
  • Sara Cherry
  • Qi Zheng
  • Shelly Bambina
  • Yaanik Desai
  • Isabelle Dragomir
  • Yongbin Chen
  • Brian D Gregory

Detail Information

Publications30

  1. ncbi Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis
    John P Wing
    Biology Department, University of Massachusetts at Amherst, Amherst, MA 01003, USA
    Nat Cell Biol 4:451-6. 2002
    ..Morgue may thus have a key function in apoptosis by targeting DIAP1 for ubiquitination and turnover...
  2. pmc Impairment of ubiquitylation by mutation in Drosophila E1 promotes both cell-autonomous and non-cell-autonomous Ras-ERK activation in vivo
    Hua Yan
    Department of Oncological Sciences, The Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Sci 122:1461-70. 2009
    ....
  3. pmc The E1 ubiquitin-activating enzyme Uba1 in Drosophila controls apoptosis autonomously and tissue growth non-autonomously
    Tom V Lee
    The University of Texas M D Anderson Cancer Center, Department of Biochemistry and Molecular Biology, Houston, TX 77030, USA
    Development 135:43-52. 2008
    ..Here, we report the characterization of Uba1, the only E1 in Drosophila...
  4. ncbi Axon pruning during Drosophila metamorphosis: evidence for local degeneration and requirement of the ubiquitin-proteasome system
    Ryan J Watts
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Neuron 38:871-85. 2003
    ..role of the ubiquitin-proteasome system in axon pruning; for example, loss-of-function mutations of the ubiquitin activating enzyme (E1) or proteasome subunits in MB neurons block axon pruning...
  5. ncbi The ubiquitin proteasome system acutely regulates presynaptic protein turnover and synaptic efficacy
    Sean D Speese
    Department of Biology, 257 South 1400 East, University of Utah, Salt Lake City, UT 84112 0840, USA
    Curr Biol 13:899-910. 2003
    ..We hypothesized that the UPS may acutely determine the local concentration of key regulatory proteins at neuronal synapses as a means for locally modulating synaptic efficacy and the strength of neurotransmission communication...
  6. ncbi Mutation of the gene encoding the ubiquitin activating enzyme ubal causes tissue overgrowth in Drosophila
    Cathie M Pfleger
    Massachusetts General Hospital Canter Center, Massachusetts General Hospital, Chrlestown, Massachusetts, USA
    Fly (Austin) 1:95-105. 2007
    ..In a screen for mutations that cause tissue overgrowth, we recovered multiple mutations in the Drosophila Uba1 gene that encodes the E1 enzyme that is required for the first step of most, if not all, ubiquitination reactions...
  7. pmc Screening of suppressors of bax-induced cell death identifies glycerophosphate oxidase-1 as a mediator of debcl-induced apoptosis in Drosophila
    Jessie Colin
    Universite Versailles St Quentin, Laboratoire de Genetique et Biologie Cellulaire, Montigny le Bretonneux, France École Pratique des Hautes Études, Laboratoire de génétique moléculaire et physiologique, Montigny le Bretonneux, France
    Genes Cancer 6:241-53. 2015
    ..Among these suppressors, Glycerophosphate oxidase-1 is found to participate in debcl-induced apoptosis by increasing mitochondrial reactive oxygen species accumulation. ..
  8. doi The drosophila Bcl-2 family protein Debcl is targeted to the proteasome by the β-TrCP homologue slimb
    Jessie Colin
    Laboratoire de Genetique et Biologie Cellulaire, EA4589, Universite de Versailles Saint Quentin en Yvelines, Ecole Pratique des Hautes Etudes, Bâtiment Simone Veil, 2 avenue de la Source de la Bièvre, 78180, Montigny le Bretonneux, France
    Apoptosis 19:1444-56. 2014
    ..designed to identify regulators of mammalian bax-induced apoptosis in Drosophila, we identified the ubiquitin activating enzyme Uba1 as a suppressor of bax-induced cell death...
  9. pmc Synergistic effects on dopamine cell death in a Drosophila model of chronic toxin exposure
    Ciara A Martin
    UCLA Interdepartmental Program in Molecular Toxicology, Los Angeles, CA 90095, United States Electronic address
    Neurotoxicology 44:344-51. 2014
    ..These studies establish a model for long-term exposure to multiple pesticides, and support the idea that pesticide interactions relevant to PD may involve inhibition of protein ubiquitination. ..
  10. pmc Multiple mechanisms modulate distinct cellular susceptibilities toward apoptosis in the developing Drosophila eye
    Yun Fan
    Department of Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA Electronic address
    Dev Cell 30:48-60. 2014
    ..Similar complexities may regulate apoptosis susceptibilities in mammalian development, and tumor cells may take advantage of it. ..
  11. pmc The SCFSlimb E3 ligase complex regulates asymmetric division to inhibit neuroblast overgrowth
    Song Li
    Neuroscience and Behavioral Disorders Program, Duke National University of Singapore Graduate Medical School Singapore, Singapore City, Singapore
    EMBO Rep 15:165-74. 2014
    ..Moreover, Beta-transducin repeat containing, the human ortholog of Slimb, is frequently deleted in highly aggressive gliomas, suggesting a conserved tumor suppressor-like function. ..
  12. ncbi A conditional pan-neuronal Drosophila model of spinocerebellar ataxia 7 with a reversible adult phenotype suitable for identifying modifier genes
    Morwena Latouche
    Institut National de la Sante et de la Recherche Medicale, Unité 679, Paris F 75013, France
    J Neurosci 27:2483-92. 2007
    ..Sodium butyrate, a histone deacetylase inhibitor, improved the survival time of the neurons. This model is therefore a powerful tool for studying SCA7 and for the development of potential therapies for polyQ diseases...
  13. pmc Uba1 functions in Atg7- and Atg3-independent autophagy
    Tsun Kai Chang
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Cell Biol 15:1067-78. 2013
    ..Rather, Uba1, the E1 enzyme used in ubiquitylation, is required for autophagy and reduction of cell size...
  14. pmc Homeostatic control of Argonaute stability by microRNA availability
    Peter Smibert
    Department of Developmental Biology, Sloan Kettering Institute, New York, New York, USA
    Nat Struct Mol Biol 20:789-95. 2013
    ..We conclude that Argonaute levels are finely tuned by cellular availability of mature miRNAs and the ubiquitin-proteasome system. ..
  15. pmc Genetic control of programmed cell death (apoptosis) in Drosophila
    Dongbin Xu
    The University of Texas MD Anderson Cancer Center, The Genes and Development Graduate Program, Department of Biochemistry and Molecular Biology, Houston, Texas 77030, USA
    Fly (Austin) 3:78-90. 2009
    ..Here, we review the key players of the cell death pathway in Drosophila and discuss their roles in apoptotic and non-apoptotic processes...
  16. pmc Non-cell autonomous control of apoptosis by ligand-independent Hedgehog signaling in Drosophila
    A E Christiansen
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Genes and Development Graduate Program, 1515 Holcombe Boulevard Unit 1000, Houston, TX 77030, USA
    Cell Death Differ 20:302-11. 2013
    ..This non-cell autonomous control of apoptosis highlights an underappreciated function of deregulated Hh signaling, which may help to generate a supportive micro-environment for tumor development...
  17. pmc Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila
    Shuang Li
    Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
    PLoS Biol 10:e1001239. 2012
    ..Inactivation of the ubiquitin activating enzyme Uba1 or perturbation of multiple components of the endocytic machinery leads to Smo accumulation and Hh ..
  18. doi Global analysis of RNA secondary structure in two metazoans
    Fan Li
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Rep 1:69-82. 2012
    ..Overall, our findings provide a global assessment of RNA folding in animals...
  19. pmc Drosophila IAP1-mediated ubiquitylation controls activation of the initiator caspase DRONC independent of protein degradation
    Tom V Lee
    Department of Biochemistry and Molecular Biology, Genes and Development Graduate Program, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS Genet 7:e1002261. 2011
    ..Finally, we show that DRONC protein accumulates in "undead" cells due to increased transcription of dronc in these cells. These data refine current models of caspase regulation by IAPs...
  20. pmc Mutation in E1, the ubiquitin activating enzyme, reduces Drosophila lifespan and results in motor impairment
    Hsiu Yu Liu
    Department of Oncological Sciences, The Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 8:e32835. 2013
    ..the role of the Ubiquitin Pathway in vivo, we studied loss-of-function mutations in the Drosophila Ubiquitin Activating Enzyme, Uba1 or E1, the most upstream enzyme in the Ubiquitin Pathway...
  21. doi A differential requirement for SUMOylation in proliferating and non-proliferating cells during Drosophila development
    Kiriaki Kanakousaki
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Development 139:2751-62. 2012
    ..Supporting this view, knockdown of SUMO or its E1 and E2 enzymes robustly disrupts proliferating cells in the developing eye, without any detectable effects on the development or differentiation of neighboring post-mitotic cells...
  22. pmc Drosophila IAP antagonists form multimeric complexes to promote cell death
    Cristinel Sandu
    Howard Hughes Medical Institute, Strang Laboratory of Apoptosis and Cancer Biology, The Rockefeller University, New York, NY 10065, USA
    J Cell Biol 190:1039-52. 2010
    ..Both targeting of Rpr to mitochondria and forced dimerization strongly promotes apoptosis. Our results reveal the functional importance of a previously unrecognized multimeric IAP antagonist complex for the induction of apoptosis...
  23. ncbi Identification of septin-interacting proteins and characterization of the Smt3/SUMO-conjugation system in Drosophila
    Hsin Pei Shih
    Department of Biology, University of North Carolina, Chapel Hill, NC 27599 USA
    J Cell Sci 115:1259-71. 2002
    ....
  24. pmc piggyBac-based mosaic screen identifies a postmitotic function for cohesin in regulating developmental axon pruning
    Oren Schuldiner
    Howard Hughes Medical Institute, Department of Biological Sciences and Neurosciences Program, Stanford University, Stanford, CA 94305, USA
    Dev Cell 14:227-38. 2008
    ..We also demonstrate a postmitotic role for SMC1 in dendrite targeting of olfactory projection neurons. We suggest that cohesin regulates diverse aspects of neuronal morphogenesis...
  25. ncbi Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development
    Andrea Page-McCaw
    Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Dev Cell 4:95-106. 2003
    ..Thus, MMPs are not required for Drosophila embryonic development, but, rather, for tissue remodeling...
  26. pmc Dendrite-specific remodeling of Drosophila sensory neurons requires matrix metalloproteases, ubiquitin-proteasome, and ecdysone signaling
    Chay T Kuo
    Howard Hughes Medical Institute and Department of Physiology, University of California, 1550 Fourth Street, Room GD484E, San Francisco, CA 94143 0725, USA
    Proc Natl Acad Sci U S A 102:15230-5. 2005
    ..These results demonstrate that, in response to environmental changes, certain neurons have cell-intrinsic abilities to completely lose their dendrites but keep their axons and subsequently regrow their dendritic arbors...
  27. pmc The ubiquitin proteasome system in synaptic and axonal degeneration: a new twist to an old cycle
    Laura Korhonen
    Dept of Neuroscience, Unit of Neurobiology, Biomedical Centre, Box 587, Uppsala University, S 75123 Uppsala, Sweden
    J Cell Biol 165:27-30. 2004
    ..Increased knowledge of the UPS in synaptic and axonal reactions may provide novel drug targets for treatments of neuronal injuries and neurodegenerative disorders...
  28. pmc A P-element insertion screen identified mutations in 455 novel essential genes in Drosophila
    Su Wan Oh
    The Laboratory of Immunobiology, National Institutes of Health, National Cancer Institute, Frederick, Maryland 21702 1201, USA
    Genetics 163:195-201. 2003
    ..Our mutation collection represents approximately 56% of the second chromosome vital genes and approximately 24% of the total vital Drosophila genes...
  29. ncbi Curbing the excesses of youth: molecular insights into axonal pruning
    David B Kantor
    Department of Neuroscience, The Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Neuron 38:849-52. 2003
    ..Recent studies provide new insights into the molecular events that underlie axon pruning and underscore the diversity of refinement processes employed by the nervous system during development...
  30. pmc Targets of microRNA regulation in the Drosophila oocyte proteome
    Kenji Nakahara
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 102:12023-8. 2005
    ..The preponderance of genes that control global protein abundance suggests this process is under tight control by miRNAs at the onset of fertilization...