Genomes and Genes
Gene Symbol: twi
Alias: CG2956, DTwist, Dmel\CG2956, EC9, TWI, Twi, Twist, bHLHb17, dip5, CG2956 gene product from transcript CG2956-RC, CG2956-PA, CG2956-PB, CG2956-PC, twi-PA, twi-PB, twi-PC
Species: fruit fly
Publications162 found, 100 shown here
- Sequence-specific transactivation of the Drosophila twist gene by the dorsal gene productC Thisse
Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medecine, Strasbourg, France
Cell 65:1191-201. 1991..biochemical studies it was hypothesized that dorsal might be responsible for the activation of the zygotic gene twist. In this report, regulatory sequences required for correct spatial and quantitative expression of twist are ..
- Muscle development is independent of innervation during Drosophila embryogenesisK Broadie
Department of Zoology, University of Cambridge, UK
Development 119:533-43. 1993..Likewise, the twist-expressing myoblasts that prefigure the adult musculature segregate normally in the absence of motor nerves, ..
- Quantitative analysis of binding motifs mediating diverse spatial readouts of the Dorsal gradient in the Drosophila embryoDmitri Papatsenko
Department of Molecular and Cell Biology, Division of Genetics, Genomics, and Development, Center for Integrative Genomics, University of California, 16 Barker Hall No 3204, Berkeley, CA 94720 3204, USA
Proc Natl Acad Sci U S A 102:4966-71. 2005..In particular, the quality of Dorsal and Twist recognition sequences correlates with the DV coordinates of gene expression relative to the Dorsal gradient...
- Pulsed contractions of an actin-myosin network drive apical constrictionAdam C Martin
Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
Nature 457:495-9. 2009..The transcription factors Twist and Snail differentially regulate pulsed constriction...
- Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factorsM S Halfon
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
Cell 103:63-74. 2000..Mad, and Pointed-functioning in the Wg, Dpp, and Ras/MAPK pathways, respectively) and two tissue-restricted (Twist and Tinman) transcription factors on a progenitor identity gene enhancer...
- Drosophila mef2 expression during mesoderm development is controlled by a complex array of cis-acting regulatory modulesH T Nguyen
Department of Medicine, Division of Cardiology, Forchheimer G42, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, 10461, USA
Dev Biol 204:550-66. 1998..region of the mef2 gene showed that the initial widespread mesodermal expression is achieved through a 280-bp twist-dependent enhancer...
- Cell shape changes during gastrulation in DrosophilaM Leptin
Max Planck Institut fur Entwicklungsbiologie, Tubingen, West Germany
Development 110:73-84. 1990..Two known zygotic genes that are required for the formation of the mesoderm, twist and snail, are expressed in ventral furrow cells, and the correct execution of cell shape changes in the mesoderm ..
- folded gastrulation, cell shape change and the control of myosin localizationRachel E Dawes-Hoang
Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, NJ 08544, USA
Development 132:4165-78. 2005..this paper, we analyze the function of the folded gastrulation gene (fog), a known target of the patterning gene twist. Our analysis of fog function therefore illuminates a molecular pathway spanning all the way from patterning gene ..
- Regulation of zygotic gene expression in Drosophila primordial germ cellsM Van Doren
Skirball Institute, NYU Medical Center, New York 10016, USA
Curr Biol 8:243-6. 1998..This expression does not require proper patterning of the soma, indicating that it is likely to be controlled by the germ plasm...
- Specification of individual Slouch muscle progenitors in Drosophila requires sequential Wingless signalingVirginia T Cox
Program in Developmental Biology, Weill Graduate School of Medical Sciences at Cornell University and Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
Development 132:713-24. 2005..Slouch cluster I, Wg signaling is required to maintain high levels of the myogenic transcriptional regulator Twist. However, to specify cluster II, Wg not only maintains high Twist levels, but also provides a second contribution ..
- Parcas, a regulator of non-receptor tyrosine kinase signaling, acts during anterior-posterior patterning and somatic muscle development in Drosophila melanogasterKaren Beckett
Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Weill Graduate School of Medical Science at Cornell University, New York, NY 10021, USA
Dev Biol 299:176-92. 2006..We propose that Pcs fulfils its distinct roles during development by the regulation of multiple NRTKs...
- Uncoupling dorsal-mediated activation from dorsal-mediated repression in the Drosophila embryoGirish S Ratnaparkhi
Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095 1569, USA
Development 133:4409-14. 2006..transcription factor Dorsal patterns the dorsoventral axis of the Drosophila embryo by activating genes such as twist and snail and repressing genes such as decapentaplegic and zerknüllt...
- Developmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regionsStewart MacArthur
Genomics Division, Lawrence Berkeley National Laboratory, Cyclotron Road MS 84 181, Berkeley, CA 94720, USA
Genome Biol 10:R80. 2009....
- Org-1, the Drosophila ortholog of Tbx1, is a direct activator of known identity genes during muscle specificationChristoph Schaub
Friedrich Alexander University of Erlangen Nuremberg, Department of Biology, Division of Developmental Biology, Staudtstrasse 5, Erlangen, Germany
Development 139:1001-12. 2012..These findings provide new insights into the regulatory circuits that control the proper pattering of the larval somatic musculature in Drosophila...
- The Drosophila protein Dof is specifically required for FGF signalingS Vincent
Biozentrum, Universität Basel Abt Zellbiologie, Switzerland
Mol Cell 2:515-25. 1998..Dof is needed in these cells for activation of the MAPK cascade via FGF signaling, but not for activation via other RTK ligands. Dof therefore appears to be committed exclusively to FGFR-mediated signal transduction...
- D-mef2: a Drosophila mesoderm-specific MADS box-containing gene with a biphasic expression profile during embryogenesisH T Nguyen
Department of Cardiology, Children s Hospital, Boston, MA 02115
Proc Natl Acad Sci U S A 91:7520-4. 1994..b>twi activity is required for D-mef2 expression, while sna function may be needed for the maintenance of D-mef2 ..
- eyelid antagonizes wingless signaling during Drosophila development and has homology to the Bright family of DNA-binding proteinsJ E Treisman
Skirball Institute of Biomolecular Medicine, NYU Medical Center, New York, New York 10016, USA
Genes Dev 11:1949-62. 1997..Based on this homology and on the phenotypic analysis, we suggest that Eld could act as a transcription factor antagonistic to the Wg pathway...
- Control of Drosophila gastrulation by apical localization of adherens junctions and RhoGEF2Verena Kölsch
Institute of Genetics, University of Cologne, Zulpicher Strasse 47, 50674 Cologne, Germany
Science 315:384-6. 2007..During Drosophila gastrulation, apical constrictions under the control of the transcription factor Twist lead to the invagination of the mesoderm...
- The control of cell fate along the dorsal-ventral axis of the Drosophila embryoR P Ray
Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138
Development 113:35-54. 1991..of the expression patterns of four zygotic patterning genes: decapentaplegic (dpp), zerknüllt (zen), twist (twi), and snail (sna)...
- twist and snail as positive and negative regulators during Drosophila mesoderm developmentM Leptin
Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
Genes Dev 5:1568-76. 1991b>twist and snail are members of the helix-loop-helix and zinc-finger protein families, respectively, and determine the development of the mesoderm in Drosophila...
- Establishment of the mesoderm-neuroectoderm boundary in the Drosophila embryoD Kosman
Biology Department, University of California, San Diego, La Jolla 92093
Science 254:118-22. 1991..patterns of gene expression along the dorsal-ventral axis of early embryos and activates the regulatory genes twist and snail, which are responsible for the differentiation of the ventral mesoderm...
- Lethal of scute, a proneural gene, participates in the specification of muscle progenitors during Drosophila embryogenesisA Carmena
Centro de Biología Molecular Severo Ochoa C S I C U A M, Universidad Autonoma, Madrid, Spain
Genes Dev 9:2373-83. 1995..Loss-of-function and overexpression phenotypes indicate a role for l'sc in the segregation of muscle progenitors and the formation of the muscle pattern...
- The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulationK Barrett
Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown 02129, USA
Cell 91:905-15. 1997..Together, these results establish a Rho-mediated signaling pathway that is essential for the major morphogenetic events in Drosophila gastrulation...
- A role for Groucho tetramerization in transcriptional repressionG Chen
Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095 1569, USA
Mol Cell Biol 18:7259-68. 1998..These findings suggest that oligomerization is essential for Gro-mediated repression and that the primary function of the conserved N-terminal domain is to mediate this oligomerization...
- The transmembrane molecule kekkon 1 acts in a feedback loop to negatively regulate the activity of the Drosophila EGF receptor during oogenesisC Ghiglione
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Cell 96:847-56. 1999..We show that the extracellular and transmembrane domains of Kek1 can inhibit and physically associate with the EGFR, suggesting potential models for this inhibitory mechanism...
- zfh-1, the Drosophila homologue of ZEB, is a transcriptional repressor that regulates somatic myogenesisA A Postigo
Division of Molecular Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Mol Cell Biol 19:7255-63. 1999..mef2 is known to be regulated by the transcription factor twist, and we show here that zfh-1 binds to sites in the mef2 upstream regulatory region and inhibits twist ..
- Dimerization partners determine the activity of the Twist bHLH protein during Drosophila mesoderm developmentI Castanon
Program in Molecular Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Development 128:3145-59. 2001The basic helix-loop-helix transcription factor Twist regulates a series of distinct cell fate decisions within the Drosophila mesodermal lineage...
- Computational models for neurogenic gene expression in the Drosophila embryoRobert P Zinzen
Center for Integrative Genomics, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720 3204, USA
Curr Biol 16:1358-65. 2006..Quantitative models based on the fractional occupancy of Dorsal, Twist, and Snail binding sites raise the possibility that cooperative interactions among these regulatory proteins ..
- Daughterless dictates Twist activity in a context-dependent manner during somatic myogenesisMing Ching Wong
Weill Graduate School of Medical Sciences, Cornell University, New York, NY, USA
Dev Biol 317:417-29. 2008..in Drosophila relies on the reiterative activity of the basic helix-loop-helix transcriptional regulator, Twist (Twi). How Twi directs multiple cell fate decisions over the course of mesoderm and muscle development is unclear...
- dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryoY T Ip
Biology Department, University of California, San Diego, La Jolla 92093 0322
Genes Dev 6:1518-30. 1992The first step in the differentiation of the Drosophila mesoderm is the activation of two regulatory genes, twist (twi) and snail (sna), in ventral regions of early embryos...
- The snail gene required for mesoderm formation in Drosophila is expressed dynamically in derivatives of all three germ layersA Alberga
Laboratoire de Génétique Moléculaire des Eucaryotes du Centre National de la Recherche Scientifique, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medicine, Strasbourg, France
Development 111:983-92. 1991..Its regional distribution generally correlates with that of sna transcripts. The complex pattern of sna expression strongly suggests that the function of the gene is not restricted to mesoderm formation...
- Beta 3 tubulin expression characterizes the differentiating mesodermal germ layer during Drosophila embryogenesisD Leiss
Gentechnologische Arbeitsgruppe, Max Planck Institut fur Biochemie, Martinsried, FRG
Development 104:525-31. 1988..In dorsalizing mutants dorsal, snail and twist, which do not form a ventral furrow during gastrulation, beta 3 expression is greatly reduced but not completely ..
- Dorsal-ventral patterning genes restrict NK-2 homeobox gene expression to the ventral half of the central nervous system of Drosophila embryosD M Mellerick
Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Dev Biol 171:306-16. 1995..b>Twist activates the NK-2 gene in the posterior portion of the embryo or is a coactivator with dorsal...
- Muscle development. Making Drosophila muscleM V Taylor
Department of Zoology, University of Cambridge, UK
Curr Biol 5:740-2. 1995..Analysis of flies with mutations in the gene encoding the D-mef2 transcription factor identifies it as a controller of differentiation in multiple muscle cell types; it is the first such gene to be described...
- Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathwayI Rebay
Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
Cell 81:857-66. 1995....
- Muscle development in the four-winged Drosophila and the role of the Ultrabithorax geneJ Fernandes
Molecular Biology Unit, Tata Institute of Fundamental Research, Bombay, India
Curr Biol 4:957-64. 1994..Many aspects of homeotic selector gene function in this process remain to be understood...
- Interacting functions of snail, twist and huckebein during the early development of germ layers in DrosophilaR Reuter
Max Planck Institut fur Entwicklungsbiologie, Abteilung V, Tubingen, FR Germany
Development 120:1137-50. 1994Two zygotic genes, snail (sna) and twist (twi), are required for mesoderm development, which begins with the formation of the ventral furrow...
- Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogenJ Jiang
Department of Biology, University of California, San Diego, La Jolla 92093 0322
Cell 72:741-52. 1993..We discuss how enhancers serve as templates to bring weakly interacting regulatory factors into close proximity so that they can function combinatorially to activate and repress transcription...
- Regulation and function of the terminal gap gene huckebein in the Drosophila blastodermG Bronner
Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
Int J Dev Biol 40:157-65. 1996..Conversely, ectopic expression of hkb inhibits the formation of the major gastrulation fold which gives rise to the mesoderm and prevents normal segmentation in the ectoderm of the trunk region...
- Patterning the dorsal longitudinal flight muscles (DLM) of Drosophila: insights from the ablation of larval scaffoldsJ J Fernandes
Biology Department, Yale University, New Haven, CT 06520 8103, USA
Development 122:3755-63. 1996..Our results show that the role of the persistent larval muscles in muscle patterning involves the partitioning of DLM myoblasts, and in doing so, they regulate formation of the correct number of DLM fibers...
- Nerve-muscle interactions during flight muscle development in DrosophilaJ J Fernandes
Dept of Biology, Yale University, New Haven, CT 06520, USA
Development 125:1769-79. 1998....
- The Rap1 GTPase functions as a regulator of morphogenesis in vivoH Asha
Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
EMBO J 18:605-15. 1999..Rap1 mutations also disrupt cell migrations and cause abnormalities in cell shape. These findings indicate a role for Rap proteins as regulators of morphogenesis in vivo...
- Invertebrate myogenesis: looking back to the future of muscle developmentM K Baylies
Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, 10021, New York, NY, USA
Curr Opin Genet Dev 11:431-9. 2001..Drosophila myogenesis has become a highly informative model for understanding the interplay between the signaling and transcriptional networks that underlie cell-fate specification during embryonic development...
- The Dorsal Rel homology domain plays an active role in transcriptional regulationSongtao Jia
Department of Chemistry and Biochemistry, University of California Los Angeles, 405 Hilgard Street, Los Angeles, CA 90095 1569, USA
Mol Cell Biol 22:5089-99. 2002..These results provide some of the first evidence that the RHD plays an active role in transcriptional regulation in intact multicellular organisms...
- The MADF-BESS domain factor Dip3 potentiates synergistic activation by Dorsal and TwistVinay Bhaskar
Department of Chemistry and Biochemistry, University of California Los Angeles, 607 Charles E Young Drive East, Los Angeles, CA 90095 1569, USA
Gene 299:173-84. 2002The transcription factors Dorsal and Twist regulate dorsoventral axis formation during Drosophila embryogenesis. Dorsal and Twist bind to closely linked DNA elements in a number of promoters and synergistically activate transcription...
- Recruitment of the proneural gene scute to the Drosophila sex-determination pathwayLisa A Wrischnik
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3204, USA
Genetics 165:2007-27. 2003..Lack of synergistic lethality among mutations in sc, twist, and dorsal argue against a proposed role for sc in mesoderm formation that had seemed potentially relevant to sex-..
- Spatial regulation of microRNA gene expression in the Drosophila embryoFrederic Biemar
Division of Genetics and Development, Department of Molecular Cell Biology, Center for Integrative Genomics, University of California, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 102:15907-11. 2005..the 8-miR enhancer is regulated by the localized Huckebein repressor, whereas miR-1 is activated by Dorsal and Twist. These results provide evidence that restricted activities of the 8-miR and miR-1 miRNAs are mediated by classical ..
- Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryoLi ying Chen
Department of Life Science, Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan 30034, Republic of China
Curr Biol 16:1183-93. 2006..weckle (wek) was previously identified as a new dorsal group gene that encodes a putative zinc finger transcription factor. However, its role in the Toll pathway was unknown...
- The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryoY T Ip
Biology Department, University of California, San Diego, La Jolla 92093 0322
Genes Dev 6:1728-39. 1992..maternal morphogen dorsal (dl) acts in concert with basic helix-loop-helix (b-HLH) proteins, possibly including twist (twi), to activate rho in both lateral and ventral regions...
- Development of the indirect flight muscles of DrosophilaJ Fernandes
Molecular Biology Unit, Tata Institute of Fundamental Research, Colaba, Bombay, India
Development 113:67-77. 1991..By morphological criteria and by patterns of specific gene expression, our experiments define events in IFM development...
- Cells with persistent twist expression are the embryonic precursors of adult muscles in DrosophilaM Bate
Department of Zoology, Cambridge, UK
Development 113:79-89. 1991b>twist expression in the embryonic mesoderm of Drosophila declines during germ band retraction to leave a residual population of twist-expressing cells in the late embryo...
- The twist gene: isolation of a Drosophila zygotic gene necessary for the establishment of dorsoventral patternB Thisse
Nucleic Acids Res 15:3439-53. 1987The twist zygotic gene appears to be involved in the establishment of the dorso-ventral pattern in Drosophila embryos...
- Drosophila MEF2 is regulated by twist and is expressed in both the primordia and differentiated cells of the embryonic somatic, visceral and heart musculatureM V Taylor
Department of Zoology, University of Cambridge, England
Mech Dev 50:29-41. 1995..DMEF2 may play a role in this important event because our experiments show that it is a downstream target for twist and that its early expression pattern modulates as the mesoderm is organising into cell groupings with distinct ..
- A putative cell signal encoded by the folded gastrulation gene coordinates cell shape changes during Drosophila gastrulationM Costa
Department of Molecular Biology, Princeton University, New Jersey 08544
Cell 76:1075-89. 1994..Our analyses indicate that cell-cell communication ensures the rapid, orderly progression of constriction initiations from the middle of invagination primordia out toward the margins...
- Broad-complex transcription factors regulate thoracic muscle attachment in DrosophilaD J Sandstrom
ARL Division of Neurobiology, University of Arizona, Tucson 85721 0077, USA
Dev Biol 181:168-85. 1997..We conclude that 20-hydroxyecdysone acts through the Broad-Complex to control the development of thoracic myotendinous junctions...
- Drosophila CBP is required for dorsal-dependent twist gene expressionH Akimaru
Laboratory of Molecular Genetics, Tsukuba Life Science Center, RIKEN, Ibaraki, Japan
Nat Genet 17:211-4. 1997..To initiate the differentiation of the mesoderm in Drosophila, multiple zygotic genes such as twist (twi) and snail (sna), which encode a basic-helix-loop-helix and a zinc finger transcription factor, respectively, ..
- Conversion of dorsal from an activator to a repressor by the global corepressor GrouchoT Dubnicoff
Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, California 90095, USA
Genes Dev 11:2952-7. 1997..Groucho is therefore a critical component of the dorsal/ventral patterning system...
- A basic-helix-loop-helix protein expressed in precursors of Drosophila longitudinal visceral musclesC Georgias
Institut fur Entwicklungsbiologie, Universitat zu Koln, Germany
Mech Dev 69:115-24. 1997..Characterisation of this expression pattern demonstrates that precursors of the outer, longitudinal muscles of the midgut are distinct in origin and morphology from precursors of the inner, circular muscles...
- ladybird determines cell fate decisions during diversification of Drosophila somatic musclesT Jagla
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, CU de Strasbourg, France
Development 125:3699-708. 1998..Altogether our results provide new insights into the genetic control of diversification of muscle precursors and indicate a further similarity between the myogenic and neurogenic pathways...
- Heartbroken is a specific downstream mediator of FGF receptor signalling in DrosophilaA M Michelson
Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA
Development 125:4379-89. 1998..A strong heartbroken allele also suppresses the effects of hyperactivated FGF but not EGF receptors. Thus, heartbroken may contribute to the specificity of developmental responses elicited by FGF receptor signalling...
- Relief of gene repression by torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterningG Jimenez
Institut de Biologia Molecular de Barcelona CSIC, 08034 Barcelona, Spain
Genes Dev 14:224-31. 2000..cic has been evolutionarily conserved, suggesting that Cic-like proteins may act as repressors regulated by RTK signaling in other organisms...
- A novel Drosophila, mef2-regulated muscle gene isolated in a subtractive hybridization-based molecular screen using small amounts of zygotic mutant RNAM V Taylor
Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, United Kingdom
Dev Biol 220:37-52. 2000..In a one-step procedure, the subtraction was 6.5- to 7.25-h wild-type embryos minus 6.5- to 7.25-h twist (twi) zygotic mutant embryos...
- Apterous mediates development of direct flight muscles autonomously and indirect flight muscles through epidermal cuesA Ghazi
National Centre for Biological Sciences, TIFR, Bangalore 560065, India
Development 127:5309-18. 2000..Our results, which may have broad implications, suggest novel mechanisms of muscle patterning in the adult, in contrast to embryonic myogenesis...
- Developmental biology. Control by combinatorial codesA Ghazi
Nature 408:419-20. 2000
- Myoblast diversification and ectodermal signaling in DrosophilaV Sudarsan
Centre for Developmental Genetics, Department of Biomedical Science, Western Bank, University of Sheffield Sheffield S10 2TN, United Kingdom
Dev Cell 1:829-39. 2001..Thus, myoblasts are divided into identifiable populations, consistent with their allocation to different muscles, and ectodermal signals act to maintain these differences...
- Genome-wide analysis of clustered Dorsal binding sites identifies putative target genes in the Drosophila embryoMichele Markstein
Department of Molecular and Cell Biology, Division of Genetics and Development, 401 Barker Hall, University of California, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 99:763-8. 2002..These results suggest that bioinformatics can be used to identify novel target genes and associated regulatory DNAs in a gene network...
- Mechanical induction of Twist in the Drosophila foregut/stomodeal primordiumEmmanuel Farge
Mechanics and Genetics of Developmental Embryogenesis Group, Unité Mixte de Recherche 168 Physico Chimie Curie, Curie Institute, 11 rue Pierre et Marie Curie, 75005 Paris, France
Curr Biol 13:1365-77. 2003..I have analyzed the effects of mechanical stress on the expression of Twist, which is normally expressed only in the most ventral cells of the cellular blastoderm embryo under the control of ..
- FGF8-like1 and FGF8-like2 encode putative ligands of the FGF receptor Htl and are required for mesoderm migration in the Drosophila gastrulaTanja Gryzik
Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
Curr Biol 14:659-67. 2004..After gastrulation Htl is essential for the differentiation of dorsal mesodermal derivatives. It is not known how Htl is activated, because its ligand has not yet been identified...
- Founder myoblasts and fibre number during adult myogenesis in DrosophilaDevkanya Dutta
National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bellary Road, Bangalore 560065, India
Development 131:3761-72. 2004..In contrast to the embryo, the selection of individual adult founder cells during myogenesis does not depend on Notch-mediated lateral inhibition. Our results suggest a general mechanism by which multi-fibre muscles can be patterned...
- Coordinated development of muscles and tendons of the Drosophila legCédric Soler
INSERM U 384, Faculte de Medecine, 28 Place Henri Dunant, 63001 Clermont Ferrand, France
Development 131:6041-51. 2004..In the third instars discs, in the vicinity of tendon progenitors, some Twist-positive myoblasts start to express the muscle founder cell marker dumbfounded (duf)...
- Cell divisions in the drosophila embryonic mesoderm are repressed via posttranscriptional regulation of string/cdc25 by HOWHelit Nabel-Rosen
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
Curr Biol 15:295-302. 2005..embryos despite a positive transcriptional string/cdc25 activation provided by the mesoderm-specific action of Twist. Whereas String/Cdc25 is negatively regulated by Tribbles in the mesoderm at these embryonic stages, the factor(s) ..
- Functional conservation of Rel binding sites in drosophilid genomesRichard R Copley
Wellcome Trust Centre for Human Genetics, Oxford University, Oxford OX3 7BN, United Kingdom
Genome Res 17:1327-35. 2007..We discuss how two types of conservation may contribute to the stabilization and optimization of a functional gene regulatory code in evolution...
- Dorsal interacting protein 3 potentiates activation by Drosophila Rel homology domain proteinsGirish S Ratnaparkhi
Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA, USA
Dev Comp Immunol 32:1290-300. 2008..Chromatin immunoprecipitation experiments in S2 cells indicate the presence of Dip3 at the promoters of these genes, and this binding requires the presence of Rel proteins at these promoters...
- Evolution acts on enhancer organization to fine-tune gradient threshold readoutsJustin Crocker
Department of Biological Sciences, Dartmouth College, Hanover, NH, USA
PLoS Biol 6:e263. 2008..Our study demonstrates that equivalence classes of CRMs are powerful tools for detecting lineage-specific adaptations by gene regulatory sequences...
- The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constrictionJessica K Sawyer
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Cell Biol 186:57-73. 2009..Instead, Cno localizes to AJs by a Rap1- and actin-dependent mechanism. These data suggest that Cno regulates linkage between AJs and the actin cytoskeleton during morphogenesis...
- Combinatorial binding predicts spatio-temporal cis-regulatory activityRobert P Zinzen
European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
Nature 462:65-70. 2009..This data-driven approach does not require previous knowledge of transcription factor sequence affinity, function or expression, making it widely applicable...
- Specificity of Notch pathway activation: twist controls the transcriptional output in adult muscle progenitorsFred Bernard
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK
Development 137:2633-42. 2010..Our analysis identifies Twist (Twi) as a crucial co-operating factor...
- Preferential genome targeting of the CBP co-activator by Rel and Smad proteins in early Drosophila melanogaster embryosPer Henrik Holmqvist
The Wenner Gren Institute, Developmental Biology, Stockholm University, Stockholm, Sweden
PLoS Genet 8:e1002769. 2012..We conclude that CBP occupancy in Drosophila embryos preferentially overlaps factors controlling dorso-ventral patterning and that CBP binds silent genes without causing histone hyperacetylation...
- The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryosJ Jiang
Department of Biological Sciences, Columbia University, New York, New York 10027
Genes Dev 5:1881-91. 1991..To determine how dl functions as an activator we have examined the promoter of the mesoderm determinant gene twist (twi)...
- Sequence of the twist gene and nuclear localization of its protein in endomesodermal cells of early Drosophila embryosB Thisse
Unité 184 de Biologie Moléculaire, Institut de Chimie Biologique, Faculte de Medecine, Strasbourg, France
EMBO J 7:2175-83. 1988The twist gene is involved in the establishment of germ layers in Drosophila embryos: twist homozygous mutant embryos fail to form the ventral furrow at gastrulation and lack mesoderm and all internal organs...
- D-MEF2: a MADS box transcription factor expressed in differentiating mesoderm and muscle cell lineages during Drosophila embryogenesisB Lilly
Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
Proc Natl Acad Sci U S A 91:5662-6. 1994..Expression of D-mef2 is dependent on the mesodermal determinants twist and snail but independent of the homeobox-containing gene tinman, which is required for visceral muscle and heart ..
- Interactions between dorsal and helix-loop-helix proteins initiate the differentiation of the embryonic mesoderm and neuroectoderm in DrosophilaS González-Crespo
Department of Biology, University of California at San Diego, La Jolla 92093 0322
Genes Dev 7:1703-13. 1993..Evidence is also presented that dl-HLH interactions involve the direct physical association of these proteins in solution mediated by the rel and HLH domains. We discuss the striking parallels in mesoderm formation and sex determination...
- heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryoS Gisselbrecht
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Dev 10:3003-17. 1996..These studies establish that Htl signaling provides a vital connection between initial formation of the embryonic mesoderm in Drosophila and subsequent cell-fate specification within this germ layer...
- A gradient of cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in DrosophilaA Bergmann
Max Planck Institut fur Entwicklungsbiologie, Abt für Genetik, Tubingen, Germany
Mech Dev 60:109-23. 1996..Genetic evidence indicates that degradation of Cactus is required, but not sufficient to translocates Dorsal completely into the nucleus...
- A direct contact between the dorsal rel homology domain and Twist may mediate transcriptional synergyJ M Shirokawa
Department of Chemistry and Biochemistry, University of California, Los Angeles 90095 1569, USA
Mol Cell Biol 17:3345-55. 1997..Here we show that Dorsal and the bHLH activator Twist synergistically activate transcription in cell culture and in vitro from a promoter containing binding sites for ..
- Requirements of DFR1/Heartless, a mesoderm-specific Drosophila FGF-receptor, for the formation of heart, visceral and somatic muscles, and ensheathing of longitudinal axon tracts in CNSE Shishido
Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Bunkyo ku, Japan
Development 124:2119-28. 1997..DFR1 mutant phenotypes were partially mimicked by the targeted expression of activated Yan, thus demonstrating the MAP kinase pathway to be involved in differentiation of mesoderm...
- Regulation of the twist target gene tinman by modular cis-regulatory elements during early mesoderm developmentZ Yin
Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
Development 124:4971-82. 1997..We provide evidence that the early-active enhancer element is a direct target of twist, a gene encoding a basic helix-loop-helix (bHLH) protein, which is necessary for tinman activation...
- Segregation of myogenic lineages in Drosophila requires numbM Ruiz Gomez
Department of Zoology, Cambridge, UK
Development 124:4857-66. 1997..Numb acts to block Notch-mediated repression of genes expressed in muscle progenitor cells. Thus asymmetric cell divisions are essential determinants of muscle fates during myogenesis in Drosophila..
- DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in DrosophilaU Hacker
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115 USA
Genes Dev 12:274-84. 1998....
- Twist and Notch negatively regulate adult muscle differentiation in DrosophilaS Anant
National Centre for Biological Sciences, Bangalore, India
Development 125:1361-9. 1998b>Twist is required in Drosophila embryogenesis for mesodermal specification and cell-fate choice. We have examined the role of Twist and Notch during adult indirect flight muscle development...
- Dual functions of the heartless fibroblast growth factor receptor in development of the Drosophila embryonic mesodermA M Michelson
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Dev Genet 22:212-29. 1998..Finally, parallels between requirements for FGFR signaling in Drosophila and vertebrate mesoderm development are considered...
- Transcriptional repression by the Drosophila giant protein: cis element positioning provides an alternative means of interpreting an effector gradientG F Hewitt
Department of Biochemistry, Michigan State University, East Lansing, MI 48823, USA
Development 126:1201-10. 1999..We also demonstrate that a chimeric Gal4-Giant protein lacking the basic/zipper domain can specifically repress reporter genes, suggesting that the Giant effector domain is an autonomous repression domain...
- A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila developmentG Chen
Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095 USA
Genes Dev 13:2218-30. 1999..They also provide evidence for a specific role of Rpd3 in early development...
- A Twist in fate: evolutionary comparison of Twist structure and functionIrinka Castanon
Program in Molecular Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Gene 287:11-22. 2002..Since the discovery of the twist gene, there has been great progress toward unraveling the molecular mechanisms that control mesoderm specification ..
- Krapfen/dMyd88 is required for the establishment of dorsoventral pattern in the Drosophila embryoIphigenie Charatsi
Abteilung Genetik, Max Planck Institut fur Entwicklungsbiologie, Spemannstrasse 35, 72076 Tubingen, Germany
Mech Dev 120:219-26. 2003..Tube in turn interacts with its downstream effector Pelle through death domain association. We therefore suggest that upon Toll activation, Kra associates with Pelle and Tube, in an heterotrimeric complex...
- Control of apterous by vestigial drives indirect flight muscle development in DrosophilaF Bernard
Institut Jacques Monod, UMR 7592 CNRS, Universite Paris 7, Tour 43, 2, place Jussieu, 75251 Paris Cedex 05, France
Dev Biol 260:391-403. 2003..In addition, in vg(null) adult flies, degenerating DLMs express twist (twi) ectopically...
- Evolution of the ventral midline in insect embryosRobert P Zinzen
Department of Molecular and Cell Biology, Division of Genetics, Genomics, and Development, Center for Integrative Genomics, University of California, Berkeley, California 94720, USA
Dev Cell 11:895-902. 2006..sim is regulated by a combination of Notch signaling and a Twist (Twi) activator gradient in D. mel., but it is activated solely by Twi in A. mel...
- Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in DrosophilaDonald T Fox
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
Development 134:567-78. 2007..These observations identify an important morphogenetic role for Abl and suggest a conserved mechanism for this kinase during apical cell constriction...
- Shaping leg muscles in Drosophila: role of ladybird, a conserved regulator of appendicular myogenesisTariq Maqbool
Institut National de la Santé et de la Recherche Médicale U384, Faculte de Medecine, Clermont Ferrand, France
PLoS ONE 1:e122. 2006..The ladybird/Lbx1 gene family appears as a part of an ancient genetic circuitry determining leg-specific properties of myoblasts and making an appendage adapted for locomotion...
- Transcription factors bind thousands of active and inactive regions in the Drosophila blastodermXiao Yong Li
Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
PLoS Biol 6:e27. 2008....
- Hydrodynamic simulation of multicellular embryo invaginationPhilippe Alexandre Pouille
Institut Curie, Centre de Recherche, Paris, F 75248 France
Phys Biol 5:015005. 2008....
- Regulation of MeCP2 by CREB-induced microRNAsRichard H Goodman; Fiscal Year: 2010..The studies described in this proposal address a completely novel mechanism of gene regulation that has implications for the understanding of MeCP2 biology and neural development in general. ..
- Pancreas-specific primary regulatory targets of Nkx2.2DERVLA MELLERICK DRESSLER; Fiscal Year: 2004..2 target genes. This knowledge may be highly instructive in defining those regulatory networks required for beta islet specification. ..
- High-Volume Confocal Imaging SystemStephen Crews; Fiscal Year: 2005..The Pascal will allow the labs to expeditiously and comprehensively study the cellular basis of embryonic development in combination with existing bright-field and spinning disk microscopes. ..
- RECEPTORS AND SIGNALING IN NEUROENDOCRINE SYSTEMSRichard Goodman; Fiscal Year: 2006..Core laboratories for cell culture, protein chemistry, and administration are designed to allow the proposed studies to be performed in an efficient and cost-effective manner. ..
- Computational and Functional Analysis of Gene NetworksMARC HALFON; Fiscal Year: 2006..abstract_text> ..
- Axon stabilization: A role for glia in patterning adult innervation in DrosophilaJoyce Fernandes; Fiscal Year: 2006..unreadable] [unreadable]..
- Biology of Serine Proteases and SerpinsCarl Hashimoto; Fiscal Year: 2010..abstract_text> ..
- L1-MEDIATED RECRUITMENT OF THE MEMBRANE SKELETONMichael Hortsch; Fiscal Year: 2002..Finally, he will use this assay system to test whether mutant L1-CAM molecules from human patients will function in his assay. ..
- Molecular Genetics of Midline Glial DevelopmentStephen T Crews; Fiscal Year: 2010..abstract_text> ..
- Mechanisms Regulating Myoblast Fusion in DrosophilaMary K Baylies; Fiscal Year: 2010....
- Molecular and genetic analysis of sanpodoJames B Skeath; Fiscal Year: 2010..Such insight should help us understand the etiology of diseases in which this process is de-regulated and design new methods to treat these diseases. ..
- TRANSCRIPTIONAL COACTIVATORS IN ENDOCRINE REGULATIONRichard Goodman; Fiscal Year: 2003..Finally, we will characterize the ability of the "CREB binding domain" of CBP to interact with other transcription factors activated or inhibited by Ser/Thr phosphorylation. ..
- HOW DOES VND INTEGRATE POSITIONAL INFORMATION?DERVLA MELLERICK DRESSLER; Fiscal Year: 2003..These studies address the structure and function of vnd, a critical regulator of early neuronal development, and may serve as a prototype for vertebrate vnd-like genes. ..
- Pruning of Motor Neuronal ArborsJoyce Fernandes; Fiscal Year: 2003..These studies will have implications for better understanding the neurodevelopmental basis of diseases such as epilepsy, schizophrenia and Rett's syndrome, where pruning is thought to be defective. ..
- CELL FATE DETERMINATION IN THE MESODERM OF DROSOPHILAMary Baylies; Fiscal Year: 2008..published and preliminary data, we propose that the combined activities of 5 transcriptional regulators, Kruppel, Twist, Apterous, Caupolican, and Muscle Segment Homeobox, control the morphogenesis of the lateral muscles...
- Identification of gene targets for morphine and other drugs of abuseRichard Goodman; Fiscal Year: 2009..The concept that CREB signaling induces mediators of translational arrest has profound implications for the understanding of drug action. ..
- SUMO conjugation in cell biology and DevelopmentAlbert J Courey; Fiscal Year: 2010..Consequently, the research proposed here will advance our understanding of human disease. ..
- REGULATORS OF MUSCLE DIFFERENTIATIONHanh Nguyen; Fiscal Year: 2004..Some of the principles arising from studies in the muscle system may also be applicable to other developmental systems, and thus will potentially contribute to our understanding of other developmental defects in humans. ..