tsl

Summary

Gene Symbol: tsl
Description: torso-like
Alias: CG6705, Dm-tsl, Dmel\CG6705, Tsl, fs(3)00617, CG6705 gene product from transcript CG6705-RB, CG6705-PA, CG6705-PB, CG6705-PC, Torso-like, fs(3)torso-like, torso like, torsolike, tsl-PA, tsl-PB, tsl-PC
Species: fruit fly

Top Publications

  1. pmc Two distinct but convergent groups of cells trigger Torso receptor tyrosine kinase activation by independently expressing torso-like
    Marc Furriols
    Institut de Biologia Molecular de Barcelona Consejo Superior de Investigaciones Científicas, Institut de Recerca Biomedica de Barcelona, C Josep Samitier 1 5, 08028 Barcelona, Spain
    Proc Natl Acad Sci U S A 104:11660-5. 2007
  2. ncbi Control of Drosophila body pattern by the hunchback morphogen gradient
    G Struhl
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Cell 69:237-249. 1992
  3. ncbi The spatial control of Torso RTK activation: a C-terminal fragment of the Trunk protein acts as a signal for Torso receptor in the Drosophila embryo
    A Casali
    Institut de Biologia Molecular de Barcelona, CSIC, C Jordi Girona 18 26, Spain
    Development 128:1709-15. 2001
  4. ncbi Dissecting the mechanism of torso receptor activation
    M Furriols
    Centre d Investigació i Desenvolupament CSIC, Barcelona, Spain
    Mech Dev 70:111-8. 1998
  5. pmc Cell surface proteins Nasrat and Polehole stabilize the Torso-like extracellular determinant in Drosophila oogenesis
    Gerardo Jiménez
    Instituto de Biologia Molecular de Barcelona CSIC, 08034 Barcelona, Spain
    Genes Dev 16:913-8. 2002
  6. pmc In and out of Torso RTK signalling
    Marc Furriols
    Institut de Biologia Molecular de Barcelona CSIC, C Jordi Girona 18 26, E 08034 Barcelona, Spain
    EMBO J 22:1947-52. 2003
  7. ncbi The Drosophila embryonic patterning determinant torsolike is a component of the eggshell
    Leslie M Stevens
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Curr Biol 13:1058-63. 2003
  8. pmc A new Drosophila Ca2+/calmodulin-dependent protein kinase (Caki) is localized in the central nervous system and implicated in walking speed
    J R Martin
    Institut Pasteur, Paris, France
    EMBO J 15:1865-76. 1996
  9. ncbi torso-like encodes the localized determinant of Drosophila terminal pattern formation
    S Savant-Bhonsale
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Genes Dev 7:2548-55. 1993
  10. ncbi Terminal pattern elements in Drosophila embryo induced by the torso-like protein
    J R Martin
    Institut Pasteur, Laboratoire de Biologie Moléculaire de la Drosophile, Paris, France
    Nature 367:741-5. 1994

Research Grants

Scientific Experts

  • Elizabeth J Duncan
  • G W Brodland
  • Z Paroush
  • Jennifer A Zallen
  • E Bier
  • Girish Deshpande
  • D J Montell
  • R Rivera-Pomar
  • Marc Furriols
  • Emmanuel Farge
  • Jordi Casanova
  • Christiane N Nüsslein-Volhard
  • G Jimenez
  • ELLEN LEMOSY
  • Rodrigo Fernandez-Gonzalez
  • Einat Cinnamon
  • Aharon Helman
  • Neta Rahimi
  • Johannes Stegmaier
  • Claire M Lye
  • Michelle A Henstridge
  • Eleni Panousopoulou
  • Yu Chiun Wang
  • Marco Grillo
  • Vito Conte
  • Eric F Wieschaus
  • Maria Elena Fernandez-Sanchez
  • Adam C Martin
  • Gemma Ventura
  • Amir Orian
  • Alexander M Berezhkovskii
  • Karen L Pope
  • Sara Morais da Silva
  • Ava E Brent
  • J Todd Blankenship
  • José Manuel de Las Heras
  • N Perrimon
  • Sean E McGuire
  • William C Lemon
  • Neta Degani
  • Yinan Wan
  • Inna Averbukh
  • Katie McDole
  • George Teodoro
  • Naama Barkai
  • Fernando Amat
  • Ben Zion Shilo
  • Eyal D Schejter
  • Leslie M Stevens
  • Michal Haskel-Ittah
  • Philipp J Keller
  • Ralf Mikut
  • Guy B Blanchard
  • Huw W Naylor
  • Jan Huisken
  • Leila Muresan
  • Richard J Adams
  • Benedicte Sanson
  • Samir Merabet
  • Travis K Johnson
  • James C Whisstock
  • Sheng Zhang
  • Coral G Warr
  • Jeremy B A Green
  • Zia Khan
  • A Casali
  • Jose Munoz
  • Xavier Franch-Marro
  • Cristina de Miguel
  • Wayne Brodland
  • J T Blankenship
  • Buzz Baum
  • Mark Miodownik
  • Jim Veldhuis
  • Florian Ulrich
  • Zvi Hayouka
  • J R Martin
  • Sharon Mezuman
  • Tonia Von Ohlen
  • Padra Ahmadi
  • Vitor Barbosa
  • Fanny Serman
  • Michael Gelbart
  • Nicolas Martin
  • C Desplan
  • V Schaeffer
  • Matthias Kaschube
  • Sérgio de Matos Simões
  • Mathieu Coppey
  • Jens Christian Röper

Detail Information

Publications85

  1. pmc Two distinct but convergent groups of cells trigger Torso receptor tyrosine kinase activation by independently expressing torso-like
    Marc Furriols
    Institut de Biologia Molecular de Barcelona Consejo Superior de Investigaciones Científicas, Institut de Recerca Biomedica de Barcelona, C Josep Samitier 1 5, 08028 Barcelona, Spain
    Proc Natl Acad Sci U S A 104:11660-5. 2007
    ..Our results illustrate how independently acquired expression of a signaling molecule can constitute a mechanism by which distinct groups of cells act together in the activation of a signaling pathway...
  2. ncbi Control of Drosophila body pattern by the hunchback morphogen gradient
    G Struhl
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Cell 69:237-249. 1992
    ..Thus, hb protein functions as a classical morphogen, triggering several distinct responses as a function of its graded distribution...
  3. ncbi The spatial control of Torso RTK activation: a C-terminal fragment of the Trunk protein acts as a signal for Torso receptor in the Drosophila embryo
    A Casali
    Institut de Biologia Molecular de Barcelona, CSIC, C Jordi Girona 18 26, Spain
    Development 128:1709-15. 2001
    ..We therefore propose that the restricted activation of the torso receptor is defined by the spatial control of the proteolytic processing of the trunk protein...
  4. ncbi Dissecting the mechanism of torso receptor activation
    M Furriols
    Centre d Investigació i Desenvolupament CSIC, Barcelona, Spain
    Mech Dev 70:111-8. 1998
    ..how this signal is generated, although it is known to depend on the activity of many genes such as torso-like (tsl) and trunk (trk)...
  5. pmc Cell surface proteins Nasrat and Polehole stabilize the Torso-like extracellular determinant in Drosophila oogenesis
    Gerardo Jiménez
    Instituto de Biologia Molecular de Barcelona CSIC, 08034 Barcelona, Spain
    Genes Dev 16:913-8. 2002
    ..Stabilization of secreted factors by specialized pericellular proteins may be a general mechanism during signaling and developmental patterning...
  6. pmc In and out of Torso RTK signalling
    Marc Furriols
    Institut de Biologia Molecular de Barcelona CSIC, C Jordi Girona 18 26, E 08034 Barcelona, Spain
    EMBO J 22:1947-52. 2003
  7. ncbi The Drosophila embryonic patterning determinant torsolike is a component of the eggshell
    Leslie M Stevens
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Curr Biol 13:1058-63. 2003
    ..The spatial regulation of Trk processing is thought to be mediated by the secreted product of the torsolike (tsl) gene, which is expressed during oogenesis by a specialized population of follicle cells present at the two ..
  8. pmc A new Drosophila Ca2+/calmodulin-dependent protein kinase (Caki) is localized in the central nervous system and implicated in walking speed
    J R Martin
    Institut Pasteur, Paris, France
    EMBO J 15:1865-76. 1996
    ..In the adult head, immunohistochemistry reveals Caki protein in the lamina, the neuropil of the medulla, lobula, lobula plate and in the central brain. Mutant caki flies show reduced walking speed in 'Buridan's paradigm'...
  9. ncbi torso-like encodes the localized determinant of Drosophila terminal pattern formation
    S Savant-Bhonsale
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Genes Dev 7:2548-55. 1993
    ..and posterior poles of the Drosophila embryo requires seven maternally expressed genes including torso-like (tsl) and torso (tor)...
  10. ncbi Terminal pattern elements in Drosophila embryo induced by the torso-like protein
    J R Martin
    Institut Pasteur, Laboratoire de Biologie Moléculaire de la Drosophile, Paris, France
    Nature 367:741-5. 1994
    The genes torso (tor) and torso-like (tsl) are two of the Drosophila maternal group genes implicated in a receptor tyrosine kinase signalling pathway that specifies terminal cell fate (reviewed in ref. 3)...
  11. ncbi Multicellular rosette formation links planar cell polarity to tissue morphogenesis
    J Todd Blankenship
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Dev Cell 11:459-70. 2006
    ..We propose that the generation of higher-order rosette structures links local cell interactions to global tissue reorganization during morphogenesis...
  12. pmc Myosin II dynamics are regulated by tension in intercalating cells
    Rodrigo Fernandez-Gonzalez
    Howard Hughes Medical Institute, Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065 USA
    Dev Cell 17:736-43. 2009
    ..These results demonstrate that myosin II dynamics are regulated by tension in a positive feedback loop that leads to multicellular actomyosin cable formation and efficient tissue elongation...
  13. doi closca, a new gene required for both Torso RTK activation and vitelline membrane integrity. Germline proteins contribute to Drosophila eggshell composition
    Gemma Ventura
    Institut de Biologia Molecular de Barcelona CSIC and Institut de Recerca de Biomèdica, Barcelona, Spain
    Dev Biol 344:224-32. 2010
    ..This observation also provides a new scenario that accounts for the long known contribution of germline products to vitelline membrane biogenesis and to the follicle cell-dependent activation of the Torso receptor...
  14. doi A WntD-Dependent Integral Feedback Loop Attenuates Variability in Drosophila Toll Signaling
    Neta Rahimi
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Dev Cell 36:401-14. 2016
    ..This circuit exemplifies a broadly applicable induction-contraction mechanism, which reduces patterning variability through a restricted morphogen-dependent expression of a secreted diffusible inhibitor. ..
  15. doi Real-Time Three-Dimensional Cell Segmentation in Large-Scale Microscopy Data of Developing Embryos
    Johannes Stegmaier
    Howard Hughes Medical Institute, Janelia Research Campus, 19700 Helix Drive, Ashburn, VA 20147, USA Karlsruhe Institute of Technology, Institute for Applied Computer Science, Hermann von Helmholtz Platz 1, 76344 Eggenstein Leopoldshafen, Germany Electronic address
    Dev Cell 36:225-40. 2016
    ..4 days. RACE is easy to use, as it requires adjustment of only three parameters, takes full advantage of state-of-the-art multi-core processors and graphics cards, and is available as open-source software for Windows, Linux, and Mac OS...
  16. pmc Mechanical Coupling between Endoderm Invagination and Axis Extension in Drosophila
    Claire M Lye
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom
    PLoS Biol 13:e1002292. 2015
    ..We propose that apical constriction leading to endoderm invagination is the source of the extrinsic force contributing to germband extension. This highlights the importance of physical interactions between tissues during morphogenesis. ..
  17. doi Spindle orientation processes in epithelial growth and organisation
    Eleni Panousopoulou
    Department of Craniofacial Development and Stem Cell Biology, King s College London, Floor 27, Guy s Tower, London SE1 9RT, UK
    Semin Cell Dev Biol 34:124-32. 2014
    ..Coupling between growth perpendicular to and within epithelial planes is recognised, but so are exceptions, as is the often passive role of spindle orientation sometimes hitherto considered to be an active driver of directional growth. ..
  18. doi Trunk cleavage is essential for Drosophila terminal patterning and can occur independently of Torso-like
    Michelle A Henstridge
    1 School of Biological Sciences, Monash University, Clayton, Victoria 3800, Australia 2
    Nat Commun 5:3419. 2014
    ..must be cleaved in order to bind Tor, and that these proteolytic events are controlled by secretion of Torso-like (Tsl) only at the embryo poles...
  19. pmc Distinct Rap1 activity states control the extent of epithelial invagination via α-catenin
    Yu Chiun Wang
    Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA
    Dev Cell 25:299-309. 2013
    ..We propose a model whereby distinct activity states of Rap1 modulate α-catenin-dependent coupling between junctions and actin to control the extent of epithelial invagination...
  20. doi Canonical terminal patterning is an evolutionary novelty
    Elizabeth J Duncan
    Laboratory for Evolution and Development, Genetics Otago, Gravida, National Centre for Growth and Development, Department of Biochemistry, University of Otago, P O Box 56, Dunedin, Aotearoa, New Zealand
    Dev Biol 377:245-61. 2013
    ....
  21. pmc Conserved and divergent elements in Torso RTK activation in Drosophila development
    Marco Grillo
    Institut de Biologia Molecular CSIC and Institut de Recerca Biomèdica de Barcelona, C Baldiri Reixac 10, 08028 Barcelona, Catalonia, Spain
    Sci Rep 2:762. 2012
    ..A combination of these mechanisms is likely to allow the repeated activation of a single receptor in different contexts...
  22. pmc A biomechanical analysis of ventral furrow formation in the Drosophila melanogaster embryo
    Vito Conte
    Institute for Bioengineering of Catalonia, Barcelona, Spain
    PLoS ONE 7:e34473. 2012
    ....
  23. pmc Video force microscopy reveals the mechanics of ventral furrow invagination in Drosophila
    G Wayne Brodland
    Department of Civil and Environmental Engineering, University of Waterloo, Waterloo, ON, Canada
    Proc Natl Acad Sci U S A 107:22111-6. 2010
    ..VFM shows that in mutants with reduced junction integrity and myosin II activity, the driving forces are reduced, thus accounting for ventral furrow failure...
  24. doi Mechanical induction in embryonic development and tumor growth integrative cues through molecular to multicellular interplay and evolutionary perspectives
    Maria Elena Fernandez-Sanchez
    Mechanics and Genetics of Embryonic and Tumoral Development Group, UMR168 CNRS, Institut Curie, 11 rue Pierre et Marie Curie, F 75005, Paris, France
    Methods Cell Biol 98:295-321. 2010
    ..We discuss mechanical induction incidence in tumor development and perspective in evolution...
  25. pmc Integration of contractile forces during tissue invagination
    Adam C Martin
    Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA
    J Cell Biol 188:735-49. 2010
    ..Thus, pulsed actomyosin contractions require a supracellular, tensile meshwork to transmit cellular forces to the tissue level during morphogenesis...
  26. doi Phosphorylation of Groucho mediates RTK feedback inhibition and prolonged pathway target gene expression
    Aharon Helman
    Department of Developmental Biology and Cancer Research, Institute of Medical Research Israel Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    Curr Biol 21:1102-10. 2011
    ..Here we address this question using the Drosophila embryo, a model system that has been instrumental in elucidating the developmental functions of RTK signal transduction...
  27. pmc Oscillatory behaviors and hierarchical assembly of contractile structures in intercalating cells
    Rodrigo Fernandez-Gonzalez
    Howard Hughes Medical Institute, Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA
    Phys Biol 8:045005. 2011
    ..We discuss models to explain how the architecture of cytoskeletal networks regulates their contractile behavior and the mechanisms that give rise to oscillatory cell behaviors in intercalating cells...
  28. ncbi Mechanical induction of Twist in the Drosophila foregut/stomodeal primordium
    Emmanuel Farge
    Mechanics and Genetics of Developmental Embryogenesis Group, Unité Mixte de Recherche 168 Physico Chimie Curie, Curie Institute, 11 rue Pierre et Marie Curie, 75005 Paris, France
    Curr Biol 13:1365-77. 2003
    ..At embryogenesis gastrulation (stage 7), Twist is also expressed in the anterior foregut and stomodeal primordia...
  29. ncbi Command and control: regulatory pathways controlling invasive behavior of the border cells
    D J Montell
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, 21205 2185, Baltimore, MD, USA
    Mech Dev 105:19-25. 2001
    ..This may contribute to the metastatic effects of steroid hormones on certain cancers and the inhibition of metastasis by steroid hormone antagonists such as tamoxifen...
  30. ncbi Drosophila atrophin homolog functions as a transcriptional corepressor in multiple developmental processes
    Sheng Zhang
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06535, USA
    Cell 108:45-56. 2002
    ..We propose that Atrophin proteins function as versatile transcriptional corepressors and discuss a model that deregulation of transcription may contribute to the pathogenesis of neurodegeneration...
  31. pmc Signaling gradients in cascades of two-state reaction-diffusion systems
    Alexander M Berezhkovskii
    Mathematical and Statistical Computing Laboratory, Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:1087-92. 2009
    ..We derive analytical expressions for the steady-state concentration profiles of mobile and immobile particles and analyze how the output of a cascade is controlled by properties of the constituent stages...
  32. pmc A green fluorescent protein reporter genetic screen that identifies modifiers of Hox gene function in the Drosophila embryo
    Samir Merabet
    Laboratoire de Génétique et Physiologie du Développement IBDM, CNRS, Universite de la Mediterranee, 13288 Marseille Cedex 09, France
    Genetics 162:189-202. 2002
    ..Five of them encode products acting in or in connection with signal transduction pathways, which suggests an extensive use of signaling in the control of Hox gene function...
  33. doi Control of cell flattening and junctional remodeling during squamous epithelial morphogenesis in Drosophila
    Karen L Pope
    Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, ON, M5S 3G5, Canada
    Development 135:2227-38. 2008
    ..Genetic analysis revealed that Myosin II and Bazooka cooperate to properly position adherens junctions. These results identify a specific cellular mechanism of squamous tissue morphogenesis and molecular interactions involved...
  34. doi Multiple RTK pathways downregulate Groucho-mediated repression in Drosophila embryogenesis
    Einat Cinnamon
    Department of Biochemistry, Faculty of Medicine, The Hebrew University, Jerusalem, Israel
    Development 135:829-37. 2008
    ..We propose that phosphorylation of Groucho provides a widespread, long-term mechanism by which RTK signals control target gene expression...
  35. ncbi Overlapping mechanisms function to establish transcriptional quiescence in the embryonic Drosophila germline
    Girish Deshpande
    Department of Molecular Biology, Princeton University, Princeton, NJ 0854, USA
    Development 131:1247-57. 2004
    ..Furthermore, pgc is required to establish a repressive chromatin architecture in pole cells...
  36. ncbi Patterned gene expression directs bipolar planar polarity in Drosophila
    Jennifer A Zallen
    Department of Molecular Biology, Princeton University, Lewis Thomas Lab, Washington Road, Princeton, NJ 08544, USA
    Dev Cell 6:343-55. 2004
    ..These results indicate that spatial patterns of gene expression coordinate planar polarity across a multicellular population through the localized distribution of proteins required for cell movement...
  37. ncbi Oriented cell divisions in the extending germband of Drosophila
    Sara Morais da Silva
    Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
    Development 134:3049-54. 2007
    ..An alternative means of planar polarisation must therefore be at work in the embryonic epidermis...
  38. ncbi The bicoid morphogen papers (I): account from CNV
    Christiane N Nüsslein-Volhard
    Max Planck Institut fur Entwicklungsbiologie, Spemannstrasse 35, D 7400 Tubingen, West Germany
    Cell 116:S1-5, 2 p following S9. 2004
  39. ncbi Gene expression systems in Drosophila: a synthesis of time and space
    Sean E McGuire
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Trends Genet 20:384-91. 2004
    ....
  40. pmc Capicua integrates input from two maternal systems in Drosophila terminal patterning
    Einat Cinnamon
    Department of Biochemistry, Faculty of Medicine, Hadassah Medical School, The Hebrew University, Jerusalem, Israel
    EMBO J 23:4571-82. 2004
    ....
  41. ncbi Localized activation of RTK/MAPK pathways during Drosophila development
    E Bier
    Department of Biology, University of California, San Diego, La Jolla 92093 0349, USA
    Bioessays 20:189-94. 1998
    ..The ability to visualize the output of RTK signaling also permits detailed establishment of epistatic relationships between signaling components of RTK cascades...
  42. ncbi Permissive and instructive anterior patterning rely on mRNA localization in the wasp embryo
    Ava E Brent
    New York University, Department of Biology, Center for Developmental Genetics, 100 Washington Square East, New York, NY 10003, USA
    Science 315:1841-3. 2007
    ....
  43. ncbi Spatially distinct downregulation of Capicua repression and tailless activation by the Torso RTK pathway in the Drosophila embryo
    José Manuel de Las Heras
    Institut de Biologia Molecular de Barcelona CSIC and Institut de Recerca Biomedica, Parc Cientific de Barcelona, C Josep Samitier 1 5, 08028 Barcelona, Spain
    Mech Dev 123:481-6. 2006
    ..These data provide new insights into the mode of action of the Torso signalling pathway and on the events patterning the early Drosophila embryo...
  44. ncbi Determination of anteroposterior polarity in Drosophila
    C Nusslein-Volhard
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Federal Republic of Germany
    Science 238:1675-81. 1987
    ..Mutants in these genes lack either the anterior or posterior part of the segmented pattern. The unsegmented terminal embryonic regions require a third class of genes and form independently of the anterior and posterior centers...
  45. ncbi Interacting functions of snail, twist and huckebein during the early development of germ layers in Drosophila
    R Reuter
    Max Planck Institut fur Entwicklungsbiologie, Abteilung V, Tubingen, FR Germany
    Development 120:1137-50. 1994
    ..We suggest that mesodermal fate is determined where sna and twi but not hkb are expressed. Anteriorly hkb together with sna determines endodermal fate, and hkb together with sna and twi are required for foregut development...
  46. ncbi Signalling pathways initiated by receptor protein tyrosine kinases in Drosophila
    N Perrimon
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115
    Curr Opin Cell Biol 6:260-6. 1994
    ..e. Grb2, Sos, Ras-Gap, p21ras, Raf, MEK and MAPK, genetic studies have suggested that two novel proteins, the protein tyrosine phosphatase (PTPase) Csw and the transmembrane protein Rho, are involved in RPTK signalling...
  47. pmc A role of polycomb group genes in the regulation of gap gene expression in Drosophila
    F Pelegri
    Whitehead Institute, Howard Hughes Medical Institute, Cambridge, Massachusetts
    Genetics 136:1341-53. 1994
    ..Because Pc-G genes are thought to control gene expression by regulating chromatin, we propose that imprinting at the chromatin level underlies the determination of anteroposterior polarity in the early embryo...
  48. ncbi Receptor tyrosine kinases: genetic evidence for their role in Drosophila and mouse development
    T Pawson
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Trends Genet 6:350-6. 1990
    ....
  49. ncbi Signal transduction in the early Drosophila embryo: when genetics meets biochemistry
    N Perrimon
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115
    Trends Biochem Sci 19:509-13. 1994
    ..This pathway involves a membrane-bound receptor tyrosine kinase (RTK) that is similar to other Drosophila RTKs, such as sevenless, and the mammalian RTKs, such as the epidermal growth factor or platelet-derived growth factor receptors...
  50. ncbi Zygotic caudal regulation by hunchback and its role in abdominal segment formation of the Drosophila embryo
    C Schulz
    Zoologisches Institut, Universitat, Munchen, Germany
    Development 121:1023-8. 1995
    ..We conclude that cad is the so far missing region-specific activator of abdominal segmentation genes...
  51. ncbi Autonomous concentration-dependent activation and repression of Krüppel by hunchback in the Drosophila embryo
    C Schulz
    Zoologisches Institut, Universitat Munchen, Germany
    Development 120:3043-9. 1994
    ..In addition, we show that the artificially created hunchback gradient can organize a large part of the segment pattern, although it is expressed at a different position and in a different shape than the wild-type gradient of hunchback...
  52. ncbi Similarities between trunk and spätzle, putative extracellular ligands specifying body pattern in Drosophila
    J Casanova
    Centre d Investigació i Desenvolupament CSIC, Barcelona, Spain
    Genes Dev 9:2539-44. 1995
    ..We propose that trk encodes an extracellular ligand involved in specifying terminal body pattern and suggest by analogy with spz that a cleaved form of trk constitutes the ligand for the tor receptor...
  53. ncbi The torso pathway in Drosophila: a model system to study receptor tyrosine kinase signal transduction
    X Lu
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115
    Dev Suppl . 1993
    ..Also involved in tor signaling is the non-receptor protein tyrosine phosphatase corkscrew (csw). Here, we review the current model and discuss future research directions in this field...
  54. ncbi The egg came first, of course! Anterior-posterior pattern formation in Drosophila embryogenesis and oogenesis
    L J Manseau
    Trends Genet 5:400-5. 1989
    ..The initial spatial localizations of the maternal organizing activities are established during oogenesis. After fertilization these activities regulate zygotic gene activity along the anterior-posterior axis of the egg...
  55. ncbi Role of gap genes in early Drosophila development
    U Gaul
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Federal Republic of Germany
    Adv Genet 27:239-75. 1990
  56. ncbi Localized surface activity of torso, a receptor tyrosine kinase, specifies terminal body pattern in Drosophila
    J Casanova
    Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Genes Dev 3:2025-38. 1989
    ....
  57. ncbi l(1)pole hole is required maternally for pattern formation in the terminal regions of the embryo
    L Ambrosio
    Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115
    Development 106:145-58. 1989
    ..Thus, the maternal l(1)ph+ gene product is required for the establishment of cell identities at the anterior and posterior poles of the Drosophila embryo...
  58. ncbi Localized requirement for torso-like expression in follicle cells for development of terminal anlagen of the Drosophila embryo
    L M Stevens
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, FRG
    Nature 346:660-3. 1990
    ..Here we describe torso-like (tsl), the sixth member of the terminal gene class, and show that it is unique among these genes in that its expression ..
  59. pmc Establishment of the Deformed expression stripe requires the combinatorial action of coordinate, gap and pair-rule proteins
    T Jack
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511
    EMBO J 9:1187-98. 1990
    ..In addition, the activation code for Deformed is redundant; other pair-rule genes in addition to even-skipped can apparently act in combination with bicoid and hunchback to activate Deformed...
  60. ncbi [Oncogene research using Drosophila as a model system]
    Y Nishida
    Department of Experimental Radiology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Jpn J Genet 65:121-34. 1990
  61. ncbi Serine/threonine protein kinases in Drosophila
    E Siegfried
    Department of Genetics, Harvard Medical School, Boston, MA 02115
    Trends Genet 6:357-62. 1990
    ..This review discusses these recent findings and describes the potential for genetic analyses of kinase activity and signal transduction...
  62. ncbi From gradients to stripes in Drosophila embryogenesis: filling in the gaps
    R Rivera-Pomar
    Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Trends Genet 12:478-83. 1996
    ..Recent progress has begun to reveal the mechanisms by which coherent positional information of maternal origin becomes transferred into serially repeated zygotic gene expression domains reflecting the metameric body plan of the larva...
  63. ncbi Pair-rule gene runt restricts orthodenticle expression to the presumptive head of the Drosophila embryo
    C C Tsai
    Department of Biochemistry and Cell Biology, State University of New York, Stony Brook 11794 5215, USA
    Dev Genet 23:35-44. 1998
    ....
  64. ncbi Identifying loci required for follicular patterning using directed mosaics
    J B Duffy
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, MA 02115, USA
    Development 125:2263-71. 1998
    ..Finally, using different UAS-FLP, GAL4 and existing FRT lines, we have built stocks that permit the analysis of approximately 95% of the genome in follicular mosaics...
  65. ncbi Regulation of zygotic gene expression in Drosophila primordial germ cells
    M Van Doren
    Skirball Institute, NYU Medical Center, New York 10016, USA
    Curr Biol 8:243-6. 1998
    ..This expression does not require proper patterning of the soma, indicating that it is likely to be controlled by the germ plasm...
  66. ncbi Establishment of dorsal-ventral and terminal pattern in the Drosophila embryo
    D S Stein
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Curr Opin Genet Dev 1:247-54. 1991
    ....
  67. ncbi Different levels of Ras activity can specify distinct transcriptional and morphological consequences in early Drosophila embryos
    S Greenwood
    Howard Hughes Medical Institute, and Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Development 124:4879-86. 1997
    ....
  68. ncbi Torso signalling regulates terminal patterning in Drosophila by antagonising Groucho-mediated repression
    Z Paroush
    Imperial Cancer Research Fund, London, UK
    Development 124:3827-34. 1997
    ..We show that torso signalling permits terminal gap gene expression by antagonising Gro-mediated repression. Thus, the corepressor Gro is employed in diverse developmental contexts and, probably, by a variety of DNA-binding repressors...
  69. ncbi MAP kinase in situ activation atlas during Drosophila embryogenesis
    L Gabay
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Development 124:3535-41. 1997
    ..Since the antibody was raised against the phosphorylated form of a conserved ERK peptide containing the TEY motif, this approach is applicable to a wide spectrum of multicellular organisms...
  70. ncbi The Raf/MAP kinase cascade in cell cycle regulation and differentiation in Drosophila
    Y Nishida
    Department of Biology, School of Science, Nagoya University, Japan
    Cell Struct Funct 21:437-44. 1996
  71. ncbi Control and function of terminal gap gene activity in the posterior pole region of the Drosophila embryo
    G Bronner
    Institut fur Genetik und Mikrobiologie, Universitat Munchen, F R G
    Mech Dev 35:205-11. 1991
    ..This, in turn, suggests that the terminal gap gene activities prevent metamerization by repression of central gap genes, thereby distinguishing the segmented trunk from the nonsegmented tail region of the embryo...
  72. ncbi Neither the homeodomain nor the activation domain of Bicoid is specifically required for its down-regulation by the Torso receptor tyrosine kinase cascade
    Y Bellaiche
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Development 122:3499-508. 1996
    ..We propose that Torso does not affect the ability of Bcd to bind DNA, but instead directs modification of Bcd or of a potential Bcd co-factor, which renders the Bcd protein unable to activate transcription...
  73. ncbi Gene regulation in the Drosophila embryo
    F Sauer
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley 94720, USA
    Philos Trans R Soc Lond B Biol Sci 351:579-87. 1996
    ....
  74. ncbi Regulation of two pair-rule stripes by a single enhancer in the Drosophila embryo
    S Small
    Department of Biology, New York University, New York 10003, USA
    Dev Biol 175:314-24. 1996
    ..These findings suggest a general model for the regulation of segmentation stripes, whereby enhancers integrate positional information provided by broadly distributed activators and spatially restricted repressors...
  75. ncbi The torso receptor localizes as well as transduces the spatial signal specifying terminal body pattern in Drosophila
    J Casanova
    Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Nature 362:152-5. 1993
    ..Ligand trapping by receptor may also localize spatial signals in other patterning systems, including specification of the dorsal-ventral axis in Drosophila and of vulval cell fates in Caenorhabditis elegans...
  76. pmc Biochemical analysis of torso and D-raf during Drosophila embryogenesis: implications for terminal signal transduction
    F Sprenger
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Mol Cell Biol 13:1163-72. 1993
    ..This report provides the first biochemical analysis of the terminal signal transduction pathway in Drosophila embryos...
  77. ncbi A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in Drosophila
    L Tsuda
    Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cell 72:407-14. 1993
    ..Our genetic results demonstrate the connection between raf and the highly conserved protein kinase cascade involving MAP kinase in vivo...
  78. ncbi bicoid and the terminal system activate tailless expression in the early Drosophila embryo
    F Pignoni
    Department of Biology, University of California, Los Angeles 90024 1606
    Development 115:239-51. 1992
    ..This is the first described example of how, by jointly controlling expression of the same gene, two systems of positional information function together to set unique positional values...
  79. pmc Analysis of Krüppel control elements reveals that localized expression results from the interaction of multiple subelements
    Y Jacob
    Departement de Biologie Moleculaire, Institut Pasteur, Paris, France
    Proc Natl Acad Sci U S A 88:5912-6. 1991
    ..Finally, a protein instability motif encoded in the second exon appears to be important for resetting the dynamic Kr pattern...
  80. ncbi Segmental polarity and identity in the abdomen of Drosophila is controlled by the relative position of gap gene expression
    R Lehmann
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, West Germany
    Development 107:21-9. 1989
    ..The function of the maternal gene products becomes dispensable once the position of the zygotically expressed gap genes is determined. Subsequently the gap genes will control the pattern of the pair-rule and segment polarity genes...
  81. ncbi Regulation of the dorsal morphogen by the Toll and torso signaling pathways: a receptor tyrosine kinase selectively masks transcriptional repression
    J Rusch
    Department of Biology, University of California San Diego, La Jolla 92093 0322
    Genes Dev 8:1247-57. 1994
    ..These results suggest that RTK signaling pathways can control gene expression by antirepression, and that multiple pathways can fine-tune the activities of a single transcription factor...
  82. ncbi Developmental evolution: torso--a story with different ends?
    Jordi Casanova
    Institut de Biologia Molecular de Barcelona CSIC, Spain
    Curr Biol 15:R968-70. 2005
    ..Now, it has been found to control axis elongation in the short germ insect Tribolium. This result raises the issue of the ancestral function of the Torso pathway and its evolution...
  83. ncbi Two new roles for the Drosophila AP patterning system in early morphogenesis
    J T Blankenship
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Development 128:5129-38. 2001
    ..Our results therefore suggest a link between cytoskeletal organization during cellularization and subsequent morphogenetic processes of gastrulation...
  84. ncbi High bicoid levels render the terminal system dispensable for Drosophila head development
    V Schaeffer
    Department of Biology, New York University, New York NY 10003 USA
    Development 127:3993-9. 2000
    ..This observation is consistent with a recent evolution of an anterior morphogenetic center consisting of Bcd and anterior Tor function...
  85. ncbi Pattern formation: the eggshell holds the cue
    Ellen K LeMosy
    Department of Cellular Biology and Anatomy, Medical College of Georgia, 1459 Laney Walker Boulevard, CB2915, Augusta, GE 30901, USA
    Curr Biol 13:R508-10. 2003
    Recent data indicate that Torsolike, a spatial cue for patterning terminal structures of a Drosophila embryo, is stably anchored in the fruitfly eggshell; an as yet unidentified factor is required for the high activity of Torsolike at ..

Research Grants1

  1. Spatial Control of Proteolysis in Dorsoventral Polarity
    ELLEN LEMOSY; Fiscal Year: 2009
    ..abstract_text> ..