tkv

Summary

Gene Symbol: tkv
Description: thickveins
Alias: Atkv, Atr25D, Brk25D, Brk25D1, Brk25D2, CG14026, Dmel\CG14026, Dtfr, STK-A, TKV, TKV1, Tkv, dtfr, l(2)04415, l(2)25Da, str, tkv1, tkva, CG14026 gene product from transcript CG14026-RA, Activin-A-receptor-25D, BMP receptor kinase 25D, CG14026-PA, CG14026-PB, CG14026-PC, CG14026-PD, DPP receptor, Thick-vein, Thick-veins, slater, thick veins, thickvein, tkv-PA, tkv-PB, tkv-PC, tkv-PD
Species: fruit fly

Top Publications

  1. ncbi Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing
    T Adachi-Yamada
    Division of Biological Science, Graduate School of Science, Nagoya University, Japan Science and Technology Corporation
    Nature 400:166-9. 1999
  2. doi Dpp signaling promotes the cuboidal-to-columnar shape transition of Drosophila wing disc epithelia by regulating Rho1
    Thomas J Widmann
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany
    J Cell Sci 122:1362-73. 2009
  3. ncbi Dpp signalling orchestrates dorsal closure by regulating cell shape changes both in the amnioserosa and in the epidermis
    Beatriz García Fernández
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
    Mech Dev 124:884-97. 2007
  4. ncbi Highwire restrains synaptic growth by attenuating a MAP kinase signal
    Catherine A Collins
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Washington University, St Louis, Missouri 63110, USA
    Neuron 51:57-69. 2006
  5. pmc Retinal determination genes as targets and possible effectors of extracellular signals
    Lucy C Firth
    Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Dev Biol 327:366-75. 2009
  6. ncbi Cell proliferation, survival, and death in the Drosophila eye
    N E Baker
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Semin Cell Dev Biol 12:499-507. 2001
  7. ncbi Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure
    J R Riesgo-Escovar
    Zoologisches Institut, Universitat Zurich, Switzerland
    Genes Dev 11:1717-27. 1997
  8. ncbi Facilitated transport of a Dpp/Scw heterodimer by Sog/Tsg leads to robust patterning of the Drosophila blastoderm embryo
    Osamu Shimmi
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cell 120:873-86. 2005
  9. ncbi Regulation of cell proliferation by a morphogen gradient
    Dragana Rogulja
    Howard Hughes Medical Institute, USA
    Cell 123:449-61. 2005
  10. pmc Nervous wreck interacts with thickveins and the endocytic machinery to attenuate retrograde BMP signaling during synaptic growth
    Kate M O'Connor-Giles
    Laboratory of Genetics, University of Wisconsin Madison, Madison, WI 53706, USA
    Neuron 58:507-18. 2008

Patents

  1. High-affinity oligonucleotide ligands to the tachykinin substance P

Detail Information

Publications165 found, 100 shown here

  1. ncbi Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing
    T Adachi-Yamada
    Division of Biological Science, Graduate School of Science, Nagoya University, Japan Science and Technology Corporation
    Nature 400:166-9. 1999
    ....
  2. doi Dpp signaling promotes the cuboidal-to-columnar shape transition of Drosophila wing disc epithelia by regulating Rho1
    Thomas J Widmann
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany
    J Cell Sci 122:1362-73. 2009
    ..Our results identify a cell-autonomous role for Dpp signaling in promoting and maintaining the elongated columnar shape of wing disc cells and suggest that Dpp signaling acts by regulating Rho1 and MRLC...
  3. ncbi Dpp signalling orchestrates dorsal closure by regulating cell shape changes both in the amnioserosa and in the epidermis
    Beatriz García Fernández
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
    Mech Dev 124:884-97. 2007
    ..In summary, we show that Dpp plays a crucial role in coordinating the activity of the AS and its interactions with the LE cells during dorsal closure...
  4. ncbi Highwire restrains synaptic growth by attenuating a MAP kinase signal
    Catherine A Collins
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Washington University, St Louis, Missouri 63110, USA
    Neuron 51:57-69. 2006
    ..In addition to controlling synaptic growth, Highwire promotes synaptic function through a separate pathway that does not require wallenda...
  5. pmc Retinal determination genes as targets and possible effectors of extracellular signals
    Lucy C Firth
    Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Dev Biol 327:366-75. 2009
    ....
  6. ncbi Cell proliferation, survival, and death in the Drosophila eye
    N E Baker
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Semin Cell Dev Biol 12:499-507. 2001
    ..Reiterated episodes of cell death also contribute to precise regulation of retinal cell number. The EGF receptor homolog has multiple roles in retinal proliferation and survival...
  7. ncbi Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure
    J R Riesgo-Escovar
    Zoologisches Institut, Universitat Zurich, Switzerland
    Genes Dev 11:1717-27. 1997
    ..Interestingly, in vertebrates, transforming growth factor-beta and c-Jun regulate collagenase gene expression during wound healing, a process that also involves the closing of an epithelial sheath...
  8. ncbi Facilitated transport of a Dpp/Scw heterodimer by Sog/Tsg leads to robust patterning of the Drosophila blastoderm embryo
    Osamu Shimmi
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cell 120:873-86. 2005
    ..primary transported ligand and that the heterodimer signals synergistically through the two type I BMP receptors Tkv and Sax...
  9. ncbi Regulation of cell proliferation by a morphogen gradient
    Dragana Rogulja
    Howard Hughes Medical Institute, USA
    Cell 123:449-61. 2005
    ..Conversely, uniform activation of the DPP pathway inhibits cell proliferation in medial wing cells. Our observations provide a direct demonstration that the slope of a morphogen gradient regulates growth during development...
  10. pmc Nervous wreck interacts with thickveins and the endocytic machinery to attenuate retrograde BMP signaling during synaptic growth
    Kate M O'Connor-Giles
    Laboratory of Genetics, University of Wisconsin Madison, Madison, WI 53706, USA
    Neuron 58:507-18. 2008
    ..We propose that Nwk functions at the interface of endocytosis and BMP signaling to ensure proper synaptic growth by negatively regulating Tkv to set limits on this positive growth signal.
  11. ncbi Dependence of Drosophila wing imaginal disc cytonemes on Decapentaplegic
    Frank Hsiung
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, USA
    Nature 437:560-3. 2005
    ..We also show that the Dpp receptor, Thickveins (Tkv), is present in punctae that move along cytonemes...
  12. ncbi Myosin II regulates complex cellular arrangement and epithelial architecture in Drosophila
    Luis M Escudero
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Dev Cell 13:717-29. 2007
    ..Our work implies that regulation of the actomyosin cytoskeleton can control morphogenesis by regulating both individual cell shapes and their complex two-dimensional arrangement within epithelia...
  13. ncbi Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic
    D Nellen
    Zoologisches Institut Universität Zürich, Switzerland
    Cell 78:225-37. 1994
    ..the type I receptor family in Drosophila and demonstrate that they are encoded by the genes saxophone (sax) and thick veins (tkv)...
  14. ncbi Dpp and Notch specify the fusion cell fate in the dorsal branches of the Drosophila trachea
    P Steneberg
    Umeå Center for Molecular Pathogenesis, Umea University, S 90187, Umea, Sweden
    Mech Dev 87:153-63. 1999
    ..Ectopic expression of Dpp or the activated form of the Dpp receptor Tkv in all tracheal cells induces ectopic fusions of the tracheal lumen and ectopic expression of fusion gene ..
  15. ncbi Extrusion and death of DPP/BMP-compromised epithelial cells in the developing Drosophila wing
    Matthew C Gibson
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 307:1785-9. 2005
    ..We propose that in addition to assigning cell fates, a crucial developmental function of DPP/BMP signaling is the position-specific control of epithelial architecture...
  16. doi Growth regulation by Dpp: an essential role for Brinker and a non-essential role for graded signaling levels
    Gerald Schwank
    Institut fur Molekularbiologie, Winterthurerstr 190, CH 8057 Zurich, Switzerland
    Development 135:4003-13. 2008
    ..The Dpp-Brk system converts an inherently uneven growth program, with excessive cell proliferation in lateral regions and low proliferation in medial regions, into a spatially homogeneous profile of cell divisions throughout the disc...
  17. ncbi TGF-beta/BMP superfamily members, Gbb-60A and Dpp, cooperate to provide pattern information and establish cell identity in the Drosophila wing
    O Khalsa
    Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA
    Development 125:2723-34. 1998
    ..Furthermore, the critical ratio of Gbb-60A to Dpp signaling appears to be mediated by both Tkv and Sax type I receptors.
  18. ncbi Morphogen gradients: new insights from DPP
    S D Podos
    Department of Molecular Genetics and Cell Biology, University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA
    Trends Genet 15:396-402. 1999
    ..These reports identity additional genes and genetic circuitry necessary for this patterning system, and they highlight variations that might reflect developmental constraints within individual target cell fields...
  19. ncbi Repression of dpp targets by binding of brinker to mad sites
    H Kirkpatrick
    Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 276:18216-22. 2001
    ..Finally, we provide evidence that Brk is capable of functioning as an active repressor. Thus, whereas Brk and Mad compete for regulation of Ubx and vg, Brk may regulate other Dpp targets without direct involvement of Mad...
  20. ncbi The transcription factor Schnurri plays a dual role in mediating Dpp signaling during embryogenesis
    J Torres-Vazquez
    Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA 92697, USA
    Development 128:1657-70. 2001
    ..We find that Shn-mediated relief of brk repression establishes broad domains of gene activation, while the brk-independent input from Shn is crucial for defining the precise limits and levels of Dpp target gene expression in the embryo...
  21. ncbi Morphogen gradient interpretation
    J B Gurdon
    Wellcome CRC Institute, Cambridge, UK
    Nature 413:797-803. 2001
    ....
  22. ncbi Morphogenetic apoptosis: a mechanism for correcting discontinuities in morphogen gradients
    Takashi Adachi-Yamada
    Department of Sciences for Natural Environment, Faculty of Human Development, Kobe University, Japan
    Dev Biol 251:74-90. 2002
    ..This phenomenon is likely related to the process of cell competition, and we suggest that it is an evolutionarily important mechanism that helps prevent abnormal tissue specification and growth during development...
  23. ncbi Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient
    Bruno Muller
    Institut fur Molekularbiologie, Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Cell 113:221-33. 2003
    ..Together, our results provide the molecular framework for a mechanism by which the extracellular Dpp/BMP morphogen establishes a finely tuned, graded read-out of transcriptional repression...
  24. pmc Hox control of organ size by regulation of morphogen production and mobility
    Michael A Crickmore
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Science 313:63-8. 2006
    ..Ubx restricts Dpp's distribution in the haltere by increasing the amounts of the Dpp receptor, thickveins...
  25. ncbi Sara endosomes and the maintenance of Dpp signaling levels across mitosis
    Christian Bökel
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Science 314:1135-9. 2006
    ..Daughter cells thereby inherited equal amounts of signaling molecules and thus retained the Dpp signaling levels of the mother cell...
  26. ncbi Specifying positional information in the embryo: looking beyond morphogens
    Michel Kerszberg
    Universite Pierre et Marie Curie Paris 6, UMR7138 CNRS, 75005 Paris, France
    Cell 130:205-9. 2007
    ..It is now becoming clear that additional or alternative mechanisms involving interactions among cells are also crucial for positional specification...
  27. doi optomotor-blind suppresses instability at the A/P compartment boundary of the Drosophila wing
    Jie Shen
    Institute of Genetics, Johannes Gutenberg Universitat, Becherweg 32, 55128 Mainz, Germany
    Mech Dev 125:233-46. 2008
    ..In the larval A/P fold, DE-cadherin-based adherens junctions appeared intact but the apical microtubule web was strongly reduced...
  28. pmc Lissencephaly-1 controls germline stem cell self-renewal through modulating bone morphogenetic protein signaling and niche adhesion
    Shuyi Chen
    The Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Proc Natl Acad Sci U S A 107:19939-44. 2010
    ..Germline-specific expression of an activated BMP receptor thickveins (Tkv) or E-cadherin can partially rescue the loss phenotype of Lis1 mutant GSCs...
  29. ncbi An absolute requirement for both the type II and type I receptors, punt and thick veins, for dpp signaling in vivo
    E Ruberte
    Biozentrum Universität Basel Switzerland
    Cell 80:889-97. 1995
    ..Previous studies have indicated that the product of the Drosophila thick veins (tkv) gene is a type I receptor for decapentaplegic (dpp)...
  30. ncbi Direct and long-range action of a DPP morphogen gradient
    D Nellen
    Zoologisches Institut, Universitat Zurich, Switerland
    Cell 85:357-68. 1996
    ..Using clones of cells that express DPP, or in which DPP receptor activity has been constitutively activated or abolished, we show that DPP acts directly and at long range on ..
  31. ncbi decapentaplegic overexpression affects Drosophila wing and leg imaginal disc development and wingless expression
    S Morimura
    McArdle Laboratory for Cancer Research and Laboratory of Genetics, University of Wisconsin Medical School, Madison, Wisconsin, 53706, USA
    Dev Biol 177:136-51. 1996
    ..is detected in imaginal discs where dpp signaling is compromised by lowering the activity of one of its receptors, tkv. This antagonism between dpp and wg expression may be critical to assigning only one disc region as the distal ..
  32. ncbi Regulation of cell cycle synchronization by decapentaplegic during Drosophila eye development
    A Penton
    McArdle Laboratory for Cancer Research and Laboratory of Genetics, University of Wisconsin Medical School, Madison, WI 53706, USA
    Science 275:203-6. 1997
    ..DPP may affect cell cycle synchronization by promoting cell cycle progression through the G2-M phases. This synchronization is critical for the precise assembly of the eye...
  33. ncbi Developmental territories created by mutual antagonism between Wingless and Decapentaplegic
    H Theisen
    Developmental Biology Center and Department of Developmental and Cell Biology, University of California Irvine, 92697, USA
    Development 122:3939-48. 1996
    ..We propose that the anterior compartment of the leg disc is divided into dorsal and ventral territories by the mutual antagonism between WG and DPP signaling...
  34. pmc A novel homeobox gene mediates the Dpp signal to establish functional specificity within target cells
    H Nakagoshi
    Department of Molecular Genetics, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187 8502, Japan
    Genes Dev 12:2724-34. 1998
    ..Thus, the dve gene acts under the two distinct extracellular signals at distant parts of the midgut primordia...
  35. ncbi decapentaplegic is required for arrest in G1 phase during Drosophila eye development
    J Horsfield
    Department of Genetics, Adelaide University, South Australia, Australia
    Development 125:5069-78. 1998
    ..In addition, our results provide evidence for a Dpp-independent mechanism that acts in the posterior part of the morphogenetic furrow to maintain G1 arrest...
  36. ncbi TGF-beta family signal transduction in Drosophila development: from Mad to Smads
    L A Raftery
    Cutaneous Biology Research Center, Massachusetts General Hospital Harvard Medical School, Building 149 13th Street, Charlestown, Massachusetts, 02129, USA
    Dev Biol 210:251-68. 1999
    ..Identification of more ligand sequences and demonstration of a functional Drosophila activin-like signal transduction pathway suggest that all TGF-beta signal transduction pathways are present in flies...
  37. pmc Nuclear interpretation of Dpp signaling in Drosophila
    M Affolter
    Abteilung Zellbiologie, Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4026 Basel, Switzerland
    EMBO J 20:3298-305. 2001
    ..It remains to be seen whether similar molecular mechanisms operate in the nucleus in vertebrate systems...
  38. ncbi A HOX complex, a repressor element and a 50 bp sequence confer regional specificity to a DPP-responsive enhancer
    T Marty
    Abteilung Zellbiologie, Biozentrum, Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Development 128:2833-45. 2001
    ....
  39. ncbi Is synaptic homeostasis just wishful thinking?
    Haig Keshishian
    Molecular, Cellular, and Developmental Biology Department, Yale University, POB 208103, New Haven, CT 06520, USA
    Neuron 33:491-2. 2002
    ..2002) and Marqués et al. present evidence that BMP receptors may also influence the development of synapses. The results suggest a novel mechanism for regulating neuronal growth and synaptic homeostasis during development...
  40. ncbi PP1 binds Sara and negatively regulates Dpp signaling in Drosophila melanogaster
    Daimark Bennett
    Department of Zoology, Oxford University, South Parks Road, Oxford OX1 3PS, UK
    Nat Genet 31:419-23. 2002
    ..Together these data suggest that PP1c is targeted to Dpp receptor complexes by Sara, where it acts as a negative regulator of Dpp signaling by affecting the phosphorylation ..
  41. pmc Ectopic expression of inhibitors of protein phosphatase type 1 (PP1) can be used to analyze roles of PP1 in Drosophila development
    Daimark Bennett
    Department of Zoology, Oxford University, Oxford OX1 3PS, United Kingdom
    Genetics 164:235-45. 2003
    ..for wing overgrowth and that the interaction between PP1 and Punt requires the type I receptor Thick-veins (Tkv) but is not strongly sensitive to the level of the ligand, Decapentaplegic (Dpp), nor to that of the other type I ..
  42. ncbi Deciphering synergistic and redundant roles of Hedgehog, Decapentaplegic and Delta that drive the wave of differentiation in Drosophila eye development
    Weimin Fu
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Development 130:5229-39. 2003
    ..Notch acted in part through downregulation of Hairy; Hh signaling downregulated Hairy independently of Notch. One feature of this signaling network is to limit Dpp signaling spatially to a range coincident with Hh...
  43. ncbi Interactions between the Notch, EGFR, and decapentaplegic signaling pathways regulate vein differentiation during Drosophila pupal wing development
    Sol Sotillos
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    Dev Dyn 232:738-52. 2005
    ..Once dpp expression is initiated, Dpp and EGFR activities in the provein maintain each other and, in cooperation, determine vein cell differentiation...
  44. ncbi Spatial bistability of Dpp-receptor interactions during Drosophila dorsal-ventral patterning
    Yu Chiun Wang
    Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois 60637, USA
    Nature 434:229-34. 2005
    ....
  45. ncbi Smoothened, thickveins and the genetic control of cell cycle and cell fate in the developing Drosophila eye
    Alysia D Vrailas
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mech Dev 123:151-65. 2006
    ..We conclude that both pathways have several, but differing roles in furrow induction and cell fate and survival, but that neither directly affects cell type specification...
  46. pmc Identification of phosphatases for Smad in the BMP/DPP pathway
    Hong B Chen
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genes Dev 20:648-53. 2006
    ..We show that the mammalian PDPs are important in dephosphorylation of BMP-activated Smad1 but not TGF-beta-activated Smad2 or Smad3. Thus, PDPs specifically inactivate Smads in the BMP/DPP pathway...
  47. pmc smoothened and thickveins regulate Moleskin/Importin 7-mediated MAP kinase signaling in the developing Drosophila eye
    Alysia D Vrailas
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Development 133:1485-94. 2006
    ..Ectopic expression of Msk overcomes this block and disrupts patterning. Additionally, the MAPK cytoplasmic hold is genetically dependent on the presence of Decapentaplegic (Dpp) and Hedgehog receptors...
  48. ncbi Postsynaptic mad signaling at the Drosophila neuromuscular junction
    Veronica Dudu
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Curr Biol 16:625-35. 2006
    ..There is evidence that a retrograde, presynaptic transforming growth factor-beta (TGF-beta) signaling event regulates synapse development and function in Drosophila...
  49. pmc Molecular integration of wingless, decapentaplegic, and autoregulatory inputs into Distalless during Drosophila leg development
    Carlos Estella
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Dev Cell 14:86-96. 2008
    ..The "trigger-maintenance" model describes a mechanism by which secreted morphogens act combinatorially to induce the stable expression of target genes...
  50. pmc The BMP-binding protein Crossveinless 2 is a short-range, concentration-dependent, biphasic modulator of BMP signaling in Drosophila
    Mihaela Serpe
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Dev Cell 14:940-53. 2008
    ..Cv-2 binds the type I BMP receptor Thickveins (Tkv), and we demonstrate how the exchange of BMPs between Cv-2 and receptor can produce the observed biphasic response ..
  51. ncbi Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor
    A Penton
    McArdle Laboratory for Cancer Research, Medical School, University of Wisconsin, Madison 53706
    Cell 78:239-50. 1994
    ..Mutations affecting Brk25D map to the gene thick veins and block the expression of two decapentaplegic-responsive (dpp-responsive) genes, dpp and labial, in the ..
  52. ncbi Characterization and relationship of Dpp receptors encoded by the saxophone and thick veins genes in Drosophila
    T J Brummel
    Department of Molecular Biology and Biochemistry, University of California, Irvine 92717
    Cell 78:251-61. 1994
    ..We combine molecular and genetic approaches to establish that the Drosophila saxophone (sax) gene encodes a dpp receptor. We compare the structural properties and expression patterns of sax with a second dpp receptor encoded by the ..
  53. ncbi MADR1, a MAD-related protein that functions in BMP2 signaling pathways
    P A Hoodless
    Program in Developmental Biology, Hospital for Sick Children Toronto, Ontario, Canada
    Cell 85:489-500. 1996
    ..BMP2 treatment results in accumulation of MADR1 in the nucleus. MAD proteins may thus define a novel class of signaling molecules with nuclear function in Ser/Thr kinase receptor signaling pathways...
  54. ncbi Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye
    V Wiersdorff
    Developmental Biology Programme, EMBL, Heidelberg, Germany
    Development 122:2153-62. 1996
    ..We also present evidence for the repression of wingless transcription by dpp signaling...
  55. ncbi Dpp receptors are autonomously required for cell proliferation in the entire developing Drosophila wing
    R Burke
    Zoologisches Institut, Universitat Zurich, Switzerland
    Development 122:2261-9. 1996
    ..In the developing wing blade, somatic clones lacking the Dpp receptors Punt or Thick veins (Tkv), or lacking Schnurri, a transcription factor involved in Dpp signal interpretation, fail to grow when ..
  56. ncbi Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene
    J Kim
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison, 53706, USA
    Nature 382:133-8. 1996
    ..Signal integration must be a general feature of genes like vestigial, that regulate growth or patterning along more than one axis...
  57. ncbi The Drosophila decapentaplegic and short gastrulation genes function antagonistically during adult wing vein development
    K Yu
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla 92093, USA
    Development 122:4033-44. 1996
    ..These data support the view that Sog is a dedicated Dpp antagonist...
  58. ncbi Expression and function of decapentaplegic and thick veins during the differentiation of the veins in the Drosophila wing
    J F de Celis
    Department of Genetics, University of Cambridge, UK
    Development 124:1007-18. 1997
    ..Decapentaplegic, acting through its receptor Thick veins, activates vein differentiation and restricts expression of both veinlet and the Notch-ligand Delta to the ..
  59. ncbi Daughters against dpp modulates dpp organizing activity in Drosophila wing development
    K Tsuneizumi
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Nature 389:627-31. 1997
    ..In contrast to Mad or the activated Dpp receptor, whose overexpression hyperactivates the Dpp signalling pathway, overexpression of Dad blocks Dpp activity...
  60. ncbi Synergistic signaling by two BMP ligands through the SAX and TKV receptors controls wing growth and patterning in Drosophila
    T E Haerry
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Development 125:3977-87. 1998
    ..We present evidence that the concentration of the type I receptor TKV must be low to allow long-range DPP diffusion...
  61. ncbi The transcription factors KNIRPS and KNIRPS RELATED control cell migration and branch morphogenesis during Drosophila tracheal development
    C K Chen
    Max Planck Institut fur biophysikalische Chemie, Abt Molekulare Entwicklungsbiologie, Am Fassberg, D 37077 Gottingen, Germany
    Development 125:4959-68. 1998
    ..Furthermore, we provide evidence that the border between cells acquiring dorsal branch and dorsal trunk identity is established by the direct interaction of KNIRPS with a spalt cis-regulatory element...
  62. ncbi Cell fate specification in the Drosophila salivary gland: the integration of homeotic gene function with the DPP signaling cascade
    K D Henderson
    Department of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 2196, USA
    Dev Biol 205:10-21. 1999
    ..These components include two known receptors, the type I receptor encoded by the thick veins (tkv) gene and the type II receptor encoded by the punt (put) gene; two of the four known Drosophila members of ..
  63. ncbi Transducing the Dpp morphogen gradient in the wing of Drosophila: regulation of Dpp targets by brinker
    G Campbell
    Department of Genetics and Development, Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cell 96:553-62. 1999
    ....
  64. ncbi Dcdc42 acts in TGF-beta signaling during Drosophila morphogenesis: distinct roles for the Drac1/JNK and Dcdc42/TGF-beta cascades in cytoskeletal regulation
    M G Ricos
    Drosophila Neurobiology Laboratory and Glaxo IMCB Group, Institute of Molecular and Cell Biology, Singapore 117609, Republic of Singapore
    J Cell Sci 112:1225-35. 1999
    ..Signaling in the transforming-growth-factor-beta-like pathway is mediated by Dcdc42, and acts during the closure process to control the mechanics of the migration process, most likely via its putative effector kinase DPAK...
  65. ncbi Progression of the morphogenetic furrow in the Drosophila eye: the roles of Hedgehog, Decapentaplegic and the Raf pathway
    S Greenwood
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Development 126:5795-808. 1999
    ....
  66. ncbi Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs
    H Tanimoto
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    Mol Cell 5:59-71. 2000
    ..HH induces dpp in these cells; it also attenuates their response to DPP by downregulating expression of the DPP receptor thick veins (tkv)...
  67. ncbi Measuring dimensions: the regulation of size and shape
    S J Day
    28 St Oswalds Road, York, YO10 4PF, UK
    Development 127:2977-87. 2000
    ..We discuss a hypothesis that the local steepness of a morphogen gradient is a measure of length in one axis, a measure that is used to determine whether there will be net growth or not...
  68. ncbi Crossveinless 2 contains cysteine-rich domains and is required for high levels of BMP-like activity during the formation of the cross veins in Drosophila
    C A Conley
    Department of Zoology, University of Wisconsin, Madison, WI 53706, USA
    Development 127:3947-59. 2000
    ..These features strongly suggest that Crossveinless 2 acts extracelluarly or in the secretory pathway to directly potentiate Dpp or Gbb signaling...
  69. ncbi Dpp gradient formation in the Drosophila wing imaginal disc
    A A Teleman
    European Molecular Biology Laboratory Meyerhofstr 1 69117, Heidelberg, Germany
    Cell 103:971-80. 2000
    ..The pMAD gradient adjusted to compartment size when this was experimentally altered. These observations suggest that the Dpp activity gradient may be shaped at the level of receptor activation...
  70. ncbi Lumenal transmission of decapentaplegic in Drosophila imaginal discs
    Matthew C Gibson
    Department of Zoology, University of Washington, Seattle, WA 98195, USA
    Dev Cell 3:451-60. 2002
    ..These results are consistent with lumenal transmission of the DPP survival signal during imaginal disc development...
  71. ncbi Unrestricted synaptic growth in spinster-a late endosomal protein implicated in TGF-beta-mediated synaptic growth regulation
    Sean T Sweeney
    Department of Biochemistry, 513 Parnassus Avenue, HSE 901, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 36:403-16. 2002
    ..Furthermore, mutations in Dad, an inhibitory Smad, cause synapse overgrowth. We present a model for synaptic growth control with implications for the etiology of lysosomal storage and neurodegenerative disease...
  72. ncbi Morphogen transport along epithelia, an integrated trafficking problem
    Jean Paul Vincent
    National Institute for Medical Research, The Ridgeway Mill Hill, NW7 1AA, London, United Kingdom
    Dev Cell 3:615-23. 2002
    ..The question of how this is achieved has aroused the interest of many cell biologically minded developmental biologists...
  73. pmc Transcriptional integration of competence modulated by mutual repression generates cell-type specificity within the cardiogenic mesoderm
    Zhe Han
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Dev Biol 252:225-40. 2002
    ....
  74. ncbi Dally regulates Dpp morphogen gradient formation in the Drosophila wing
    Momoko Fujise
    Department of Biology, Tokyo Metropolitan University, Hachioji shi, Tokyo 192 0397, Japan
    Development 130:1515-22. 2003
    ..dally expression in the wing disc is controlled by the same molecular pathways that regulate expression of thick veins, which encodes a Dpp type I receptor...
  75. ncbi Specification of neuropeptide cell identity by the integration of retrograde BMP signaling and a combinatorial transcription factor code
    Douglas W Allan
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Cell 113:73-86. 2003
    ..Thus, an intrinsic transcription factor code integrates with an extrinsic retrograde signal to select a specific neuropeptide identity within peptidergic cells...
  76. ncbi dSmurf selectively degrades decapentaplegic-activated MAD, and its overexpression disrupts imaginal disc development
    Yao Yun Liang
    Michael E DeBakey Department of Surgery, Department of Molecular and Cellular Biology, Ophthalmology, Program of Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:26307-10. 2003
    ..We conclude that dSmurf specifically targets phosphorylated MAD to proteasome-dependent degradation and regulates DPP signaling during development...
  77. ncbi Physical properties of Tld, Sog, Tsg and Dpp protein interactions are predicted to help create a sharp boundary in Bmp signals during dorsoventral patterning of the Drosophila embryo
    Osamu Shimmi
    Department of Genetics, Cell Biology and Development, Howard Hughes Medical Institute, University of Minnesota, Minneapolis, MN 55455, USA
    Development 130:4673-82. 2003
    ..Such a mechanism also explains how a sharp rather than smooth signaling boundary is formed...
  78. ncbi Retrograde Gbb signaling through the Bmp type 2 receptor wishful thinking regulates systemic FMRFa expression in Drosophila
    Guillermo Marques
    Department of Genetics, Cell Biology and Development, Howard Hughes Medical Institute, University of Minnesota, Minneapolis, MN55455, USA
    Development 130:5457-70. 2003
    ..We propose that Wit and Gbb globally regulate NMJ function by controlling both the growth and transmitter release properties of the synapse as well as the expression of systemic modulators of NMJ synaptic activity...
  79. pmc Hrs mediates downregulation of multiple signalling receptors in Drosophila
    Gaspar Jekely
    European Molecular Biology Laboratory, Developmental Biology Program, Heidelberg, Germany
    EMBO Rep 4:1163-8. 2003
    ..Instead, loss of Hrs increases Dpp signalling and the level of the type-I receptor Thickveins (Tkv). Finally, most hrs-dependent receptor turnover appears to be ligand independent...
  80. ncbi Gbb/Bmp signaling is essential for maintaining germline stem cells and for repressing bam transcription in the Drosophila testis
    Eihachiro Kawase
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Development 131:1365-75. 2004
    ..dpp signaling is known to be essential for maintaining GSCs in the Drosophila ovary. This study further suggests that both Drosophila male and female GSCs use Bmp signals to maintain GSCs...
  81. ncbi Orchestrating development and function: retrograde BMP signaling in the Drosophila nervous system
    Haig Keshishian
    Department of Molecular, Cellular and Developmental Biology, Yale University, PO Box 208103, New Haven, CT 06520 8103, USA
    Trends Neurosci 27:143-7. 2004
    ..Together, the results suggest that retrograde growth factor signaling by BMPs integrates neuromuscular development and function at both local and global levels in the animal...
  82. ncbi Highwire regulates presynaptic BMP signaling essential for synaptic growth
    Brian D McCabe
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Neuron 41:891-905. 2004
    ..of a presynaptic bone morphogenetic protein (BMP) signaling cascade consisting of three receptor subunits, Wit, Tkv, and Sax, in addition to the Smad transcription factor Mad...
  83. ncbi Synaptic strengthening mediated by bone morphogenetic protein-dependent retrograde signaling in the Drosophila CNS
    Richard A Baines
    Neuroscience Group, Department of Biological Sciences, University of Warwick, Coventry, CV4 7AL, United Kingdom
    J Neurosci 24:6904-11. 2004
    ..Thus, presynaptic expression of an activated TGF-beta receptor, thickvien (tkv), or postsynaptic expression of a TGF-beta ligand, glass-bottom boat (gbb), is sufficient to phenocopy ..
  84. ncbi Independent roles of the dachshund and eyes absent genes in BMP signaling, axon pathfinding and neuronal specification
    Irene Miguel-Aliaga
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Development 131:5837-48. 2004
    ..Thus, we show that dac and eya perform entirely different functions in a single cell type to ultimately regulate a single phenotypic outcome...
  85. ncbi Genetic control of cell intercalation during tracheal morphogenesis in Drosophila
    Carlos Ribeiro
    Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Curr Biol 14:2197-207. 2004
    ..Branching is controlled by several signaling pathways, but the molecular consequences of these pathways in the responding cells are poorly understood...
  86. ncbi Extrusion of cells with inappropriate Dpp signaling from Drosophila wing disc epithelia
    Jie Shen
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Science 307:1789-90. 2005
    ..This loss correlates with extensive cytoskeletal changes followed by basal epithelial extrusion. We propose that Dpp promotes cell survival within disc epithelia by affecting cytoskeletal organization...
  87. ncbi Control of cell proliferation in the Drosophila eye by Notch signaling
    Antonio Baonza
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Dev Cell 8:529-39. 2005
    ..Delta to Notch signaling derepresses the inhibition of dE2F1 by RBF, and Delta expression depends on the secreted proteins Hedgehog and Dpp. Notch is also required for the expression of Cyclin A in the SMW...
  88. ncbi Dpp-responsive silencers are bound by a trimeric Mad-Medea complex
    Sheng Gao
    Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 280:36158-64. 2005
    ..The slight alteration of the Dpp silencers caused them to activate transcription in response to Dpp signaling, indicating that the potential for Smad complexes to recognize specific targets need not be limited to repression...
  89. ncbi Shaping BMP morphogen gradients in the Drosophila embryo and pupal wing
    MICHAEL B O'CONNOR
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Development 133:183-93. 2006
    ..Because these signaling pathway components are all conserved, these observations should shed light on how BMP signaling is modulated in vertebrate development...
  90. pmc Mechanism of G1 arrest in the Drosophila eye imaginal disc
    Luis M Escudero
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    BMC Dev Biol 7:13. 2007
    ....
  91. ncbi Drosophila Nemo antagonizes BMP signaling by phosphorylation of Mad and inhibition of its nuclear accumulation
    Yi Arial Zeng
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, V5A 1S6, Canada
    Development 134:2061-71. 2007
    ..This is the first example of the inhibition of Drosophila BMP signaling by a MAPK and represents a novel mechanism of Smad inhibition through the phosphorylation of a conserved serine residue within the MH1 domain of Mad...
  92. ncbi Drosophila T-box transcription factor Optomotor-blind prevents pathological folding and local overgrowth in wing epithelium through confining Hh signal
    Makoto Umemori
    Graduate School of Science, Kobe University, Kobe 657 8501, Japan
    Dev Biol 308:68-81. 2007
    ..In the case of the local overgrowth, it was never seen in mutants for thick veins (tkv) encoding a Dpp receptor, suggesting that the Dpp signaling pathway is divided into two antagonistic branches, one of which contains Omb...
  93. pmc Msk is required for nuclear import of TGF-{beta}/BMP-activated Smads
    Lan Xu
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 178:981-94. 2007
    ..We have thus identified new evolutionarily conserved proteins that are important in the signal transduction of TGF-beta and BMP into the nucleus...
  94. pmc Dally regulates Dpp morphogen gradient formation by stabilizing Dpp on the cell surface
    Takuya Akiyama
    Department of Genetics, Cell Biology and Development, The University of Minnesota, Minneapolis, MN 55455, USA
    Dev Biol 313:408-19. 2008
    ..Furthermore, genetic interaction experiments revealed that Dally antagonizes the effect of Thickveins (Tkv; a Dpp type I receptor) on Dpp signaling...
  95. pmc Multiple modular promoter elements drive graded brinker expression in response to the Dpp morphogen gradient
    Li Chin Yao
    Department of Developmental and Cell Biology and the Developmental Biology Center, University of California Irvine, Irvine, CA 92612, USA
    Development 135:2183-92. 2008
    ..This unusual promoter organization may be necessary for brk to respond to the Dpp gradient in a precise and robust fashion...
  96. pmc Morphogen control of wing growth through the Fat signaling pathway
    Dragana Rogulja
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Dev Cell 15:309-21. 2008
    ..These observations identify Fat as a signaling pathway that links the morphogen-mediated establishment of gradients of positional values across developing organs to the regulation of organ growth...
  97. doi Leading edge-secreted Dpp cooperates with ACK-dependent signaling from the amnioserosa to regulate myosin levels during dorsal closure
    Baharak Zahedi
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada
    Dev Dyn 237:2936-46. 2008
    ..ACK function in the amnioserosa may generate a signal cooperating with Dpp secreted from the epidermis in driving zip expression in these two tissues, ensuring that cell shape changes in dorsal closure occur in a coordinated manner...
  98. ncbi Distinct signaling of Drosophila Activin/TGF-beta family members
    Scott C Gesualdi
    Department of Biological Sciences, Center for Molecular Biology and Biotechnology, Florida Atlantic University, Boca Raton, Florida 33431, USA
    Fly (Austin) 1:212-21. 2007
    ..The distinct signaling of dACT, DAW and MYO through BABO suggests the existence of co-receptors that modulate the canonical SMAD pathway...
  99. pmc Nemo kinase interacts with Mad to coordinate synaptic growth at the Drosophila neuromuscular junction
    Carlos Merino
    Department of Physiology, McGill University, Montreal, Quebec, Canada H3G 1Y6
    J Cell Biol 185:713-25. 2009
    ..Based on our findings, we propose a model in which phosphorylation of Mad by Nmo ensures normal accumulation and distribution of Mad and thereby fine tunes BMP signaling in motor neurons...
  100. doi miR-184 has multiple roles in Drosophila female germline development
    Nicola Iovino
    Laboratory of Developmental Neurogenetics, Rockefeller University, New York, NY 10065, USA
    Dev Cell 17:123-33. 2009
    ..miR-184 controls germline stem cell differentiation by tuning the DPP receptor Saxophone, dorsoventral patterning of the egg shell by regulating the gurken transport factor K10, and ..
  101. doi The interaction between two TGF-beta type I receptors plays important roles in ligand binding, SMAD activation, and gradient formation
    Theodor E Haerry
    Florida Atlantic University, Center for Molecular Biology and Biotechnology, Boca Raton, FL 33431, USA
    Mech Dev 127:358-70. 2010
    The goal of this report is to elucidate the contributions of the Drosophila TGF-beta type I receptors TKV and SAX to the activity gradient formed by the two BMP family members DPP and GBB that play important roles in growth and ..

Research Grants20

  1. Nucleocytoplasmic Trafficking of Smads
    Lan Xu; Fiscal Year: 2008
    ..These regulators of subcellular localization potential targets for therapeutic interventions aimed at modulating TGF-beta signaling diseases such as cancer. ..
  2. MOLECULAR GENETICS OF EARLY NEUROGENESIS
    Ethan Bier; Fiscal Year: 2010
    ..These studies may provide the framework for our future studies relevant to human disease and drug abuse. ..
  3. Patterning of the Primitive Heart Tube in Zebrafish
    Jau Nian Chen; Fiscal Year: 2010
    ..The combination of cellular, molecular and genetic studies proposed in this project will provide new and in-depth insight into mechanisms of primitive heart tube morphogenesis. ..
  4. MOLECULAR BASIS OF DEVELOPMENTAL CELL INTERACTIONS
    J Marsh; Fiscal Year: 2005
    ..Finally, we have identified a collection of mutants affecting disc growth patterns that serve as an enriched collection of new candidate genes to participate in these events. ..
  5. Genetic Analysis of Bacterial Toxins in Drosophia
    Ethan Bier; Fiscal Year: 2005
    ..DN alleles 2-2: Characterize molecular lesion in DN-toxin NOVA alleles 2-3: Confirm that DN-toxin alleles interfere with wild-type toxin gene function 2-4: Determine whether DN-toxin alleles function in mammalian cells ..
  6. Identification of extrinsic signals in blood formation
    Jan Christian; Fiscal Year: 2006
    ..Understanding how normal blood development occurs is crucial to understanding and preventing disease resulting from misregulation of these pathways. ..
  7. Transgenic analysis of Smad tumor suppressor genes
    Stuart Newfeld; Fiscal Year: 2006
    ..This knowledge can be used to determine if Smad proteins should be exploited as anti-cancer drug discovery targets. ..
  8. Analysis of Early Wing Vein Development in Drosophila
    Ethan Bier; Fiscal Year: 2007
    ..Thus, knowledge gained from these studies should have broad applications to understanding vertebrate development as well as offering possible insights into mechanisms of human disease. ..
  9. Analysis of anti-growth properties of processed Follistatin proteins
    THEODOR HAERRY; Fiscal Year: 2007
    ..The final goal of the proposed work is to engineering modified FS proteins with greater anti-growth properties that could be used to combat cancers caused by mutations in TGF-b signaling components. [unreadable] [unreadable] [unreadable]..
  10. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    GERARD L CAMPBELL; Fiscal Year: 2010
    ..Consequently, the proposed studies should provide insights into diseases such as these, potentially leading to improved diagnosis and treatment. ..
  11. The molecular basis of morphological evolution
    David L Stern; Fiscal Year: 2010
    ..This detailed analysis of gene regulation promises to provide new insights into how gene regulation functions and evolves in natural species to cause possibly adaptive changes in morphology. ..
  12. Regulation of synaptic growth and plasticity in Drosophila
    KATHALEEN O CONNOR GILES; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  13. Novel Molecular Tools for Transsynaptic Circuit Analysis
    Haig Keshishian; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  14. Analysis of BMP-4 activity in Cleavage mutant mice
    Jan Christian; Fiscal Year: 2007
    ..Understanding the molecular mechanisms by which BMP activity is regulated is key to understanding, treating and preventing congenital anomalies and diseases. [unreadable] [unreadable]..
  15. Organogenesis Screen Using Tissue-Specific Zebrafish
    Jau Nian Chen; Fiscal Year: 2005
    ..Mutations identified from this screen will provide entry points to dissect genetic and molecular pathways involved in vertebrate organogenesis. ..
  16. Characterization of a novel TGF-beta signaling component
    THEODOR HAERRY; Fiscal Year: 2004
    ..This project has great potential to contribute new insights into the mechanism of TGF-Beta signaling and our understanding of the development of certain cancers. It may also provide a new target to combat these diseases. ..
  17. CONTROL OF TGF-BETA SIGNALING IN DROSOPHILA BY BRINKER
    Gerard Campbell; Fiscal Year: 2004
    ..Consequently, the present research should have direct relevance to our understanding of how defects in TGF-B signaling can lead to disease. ..
  18. IN VIVO ROLE OF PROTEOGLYCANS IN GROWTH FACTOR SIGNALING
    J Marsh; Fiscal Year: 2001
    ..Further, these in vivo studies may help in understanding the basis of some dysmorphologies in humans. ..

Patents1

  1. High-affinity oligonucleotide ligands to the tachykinin substance P
    Patent Number: US5637682-A; Date:1997-06-10