Genomes and Genes
Gene Symbol: tau
Description: CG45110 gene product from transcript CG45110-RH
Alias: BcDNA:RE16764, CG12881, CG31057, CG31058, CG34294, CG45110, CG5606, Dmel\CG45110, Dmel_CG31057, Dmel_CG31058, Dmel_CG34294, Tau, d-tau, dTau, dtau, CG45110 gene product from transcript CG45110-RH, CG45110-PA, CG45110-PB, CG45110-PC, CG45110-PE, CG45110-PF, CG45110-PG, CG45110-PH, CG45110-PI, CG45110-PJ, CG45110-PK, CG45110-PL, CG45110-PM, CG45110-PN, tau-PA, tau-PB, tau-PC, tau-PE, tau-PF, tau-PG, tau-PH, tau-PI, tau-PJ, tau-PK, tau-PL, tau-PM, tau-PN
Species: fruit fly
- Biochemical investigation of Tau protein phosphorylation status and its solubility properties in DrosophilaKaty Wing Kam Chau
Department of Biochemistry and Molecular Biotechnology Programme, The Chinese University of Hong Kong, Shatin, Hong Kong, China
Biochem Biophys Res Commun 346:150-9. 2006b>Tau hyperphosphorylation and insoluble aggregate formation are two cellular features of tauopathies. However, the contribution of Tau protein hyperphosphorylation and its aggregation to Tau pathology still remain controversial...
- TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy modelVikram Khurana
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Harvard New Research Building Room 652, 77 Louis Pasteur Avenue, Boston, Massachusetts 02115, USA
Curr Biol 16:230-41. 2006..However, the critical questions of whether cell-cycle activation is causal or epiphenomenal to tau-induced neurodegeneration and which signaling pathways mediate cell-cycle activation in tauopathy remain unresolved.
- Drosophila models of human tauopathies indicate that Tau protein toxicity in vivo is mediated by soluble cytosolic phosphorylated forms of the proteinSébastien Feuillette
INSERM U614, Rouen Institute for Medical Research, Faculty of Medicine, University of Rouen, Rouen Cedex, France
J Neurochem 113:895-903. 2010b>Tau is a neuronal microtubule-associated protein involved in microtubules assembly and stabilization...
- Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's diseaseOyinkan Sofola
Department of Genetics, Evolution, and Environment, Institute of Healthy Ageing and Research, University College London, London, United Kingdom
PLoS Genet 6:e1001087. 2010..pathogenesis of Alzheimer's disease (AD), with downstream neurotoxic effects including the hyperphosphorylation of tau protein...
- Tau phosphorylation sites work in concert to promote neurotoxicity in vivoMichelle L Steinhilb
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Mol Biol Cell 18:5060-8. 2007b>Tau is a microtubule binding protein implicated in a number of human neurodegenerative disorders, including Alzheimer's disease...
- A comparison of the neuronal dysfunction caused by Drosophila tau and human tau in a Drosophila model of tauopathiesKiren K Ubhi
Department of Neuroscience, University of Southampton, School of Biological Sciences, Bassett Crescent East, Southampton, SO16 7PX, UK
Invert Neurosci 7:165-71. 2007Hyperphosphorylation and aggregation of tau into tangles is a feature of disorders such as Alzheimer's disease and other Tauopathies...
- Study of tauopathies by comparing Drosophila and human tau in DrosophilaXinping Chen
State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
Cell Tissue Res 329:169-78. 2007The microtubule-binding protein tau has been investigated for its contribution to various neurodegenerative disorders. However, the findings from transgenic studies, using the same tau transgene, vary widely among different laboratories...
- Activation of PAR-1 kinase and stimulation of tau phosphorylation by diverse signals require the tumor suppressor protein LKB1Ji Wu Wang
Department of Pathology, Stanford University School of Medicine, and Geriatric Research, Education, and Clinical Center Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
J Neurosci 27:574-81. 2007Aberrant phosphorylation of tau is associated with a number of neurodegenerative diseases, including Alzheimer's disease (AD)...
- DAPK activates MARK1/2 to regulate microtubule assembly, neuronal differentiation, and tau toxicityP R Wu
Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
Cell Death Differ 18:1507-20. 2011..microtubule (MT) assembly by activating MARK/PAR-1 family kinases MARK1/2, which destabilize MT by phosphorylating tau and related MAP2/4...
- Identification and characterization of the Drosophila tau homologG Heidary
Department of Genetics, University of Pennsylvania School of Medicine, Stellar Chance Laboratories 709C, 422 Curie Boulevard, Philadelphia, PA 19104, USA
Mech Dev 108:171-8. 2001..The principal component of these structures is the microtubule-associated protein tau. Although tau is normally a highly soluble protein enriched in axons, in these deposits, it is abnormally ..
- Learning and memory deficits upon TAU accumulation in Drosophila mushroom body neuronsAndreas Mershin
Department of Physics and Department of Biology, Texas A and M University, College Station, Texas 77843, USA
Learn Mem 11:277-87. 2004Mutations in the neuronal-specific microtubule-binding protein TAU are associated with several dementias and neurodegenerative diseases. However, the effects of elevated TAU accumulation on behavioral plasticity are unknown...
- PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in DrosophilaIsao Nishimura
Laboratory of Developmental Neurobiology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Cell 116:671-82. 2004Multisite hyperphosphorylation of tau has been implicated in the pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD)...
- The role of PAR-1 in regulating the polarised microtubule cytoskeleton in the Drosophila follicular epitheliumHélène Doerflinger
The Wellcome Trust Cancer Research UK Institute and the Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
Development 130:3965-75. 2003..The MARKs have been proposed to destabilize microtubules by inhibiting the stabilizing activity of the Tau family of microtubule-associated proteins...
- Modification of the Drosophila model of in vivo Tau toxicity reveals protective phosphorylation by GSK3βGiulia Povellato
MRC Centre for Developmental Neurobiology, King s College London, New Hunt s House, Guy s Hospital Campus, London SE1 1UL, UK
Biol Open 3:1-11. 2014Hyperphosphorylation of the microtubule associated protein, Tau, is the hallmark of a group of neurodegenerative disorders known as the tauopathies which includes Alzheimer's disease...
- Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador associationHong Ling Huang
State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P R China
PLoS Biol 11:e1001620. 2013..Furthermore, we provided evidence that Par-1-induced Hpo regulation is conserved in mammalian cells. Taken together, our findings identified Par-1 as a novel component of the Hpo signaling network. ..
- Huntingtin functions as a scaffold for selective macroautophagyYan Ning Rui
The Brown Foundation Institute of Molecular Medicine, The University of Texas Medical School at Houston, The University of Texas Health Science Center at Houston UTHealth, 1825 Pressler Street Houston, Texas 77030, USA
Nat Cell Biol 17:262-75. 2015..Our data uncover an important physiological function of Huntingtin and provide a missing link in the activation of selective macroautophagy in metazoans. ..
- Drosophila models of proteinopathies: the little fly that couldDiego E Rincon-Limas
Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, FL 32610 0236, USA
Curr Pharm Des 18:1108-22. 2012..To remain relevant in this competitive environment, Drosophila models will need to expand their flexible, innovative, and multidisciplinary approaches to find new discoveries and translational applications...
- Cytoplasmic streaming in Drosophila oocytes varies with kinesin activity and correlates with the microtubule cytoskeleton architectureSujoy Ganguly
Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, United Kingdom
Proc Natl Acad Sci U S A 109:15109-14. 2012....
- Kinesin's neck-linker determines its ability to navigate obstacles on the microtubule surfaceGregory J Hoeprich
Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont
Biophys J 106:1691-700. 2014..kinesin-1 and kinesin-2 neck-linker chimeras stepping along microtubules in the absence or presence of two Tau isoforms, 3RS-Tau and 4RL-Tau, both of which are MAPs that are known to differentially affect kinesin-1 motility...
- Loss of Tau results in defects in photoreceptor development and progressive neuronal degeneration in DrosophilaBonnie J Bolkan
Oregon Institute of Occupational Health Sciences, Oregon Health and Science University, Portland, Oregon, 97239
Dev Neurobiol 74:1210-25. 2014..Reducing the levels of fly Tau (dTau) ubiquitously resulted in developmental lethality, whereas deleting Tau specifically in neurons or the eye caused ..
- Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsyJerrah K Holth
Developmental Neurogenetics Laboratory, Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 33:1651-9. 2013..Recently, the microtubule-binding protein tau has been implicated in the regulation of network synchronization...
- Zinc binding directly regulates tau toxicity independent of tau hyperphosphorylationYunpeng Huang
State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China
Cell Rep 8:831-42. 2014b>Tau hyperphosphorylation is thought to underlie tauopathy...
- Fast and efficient Drosophila melanogaster gene knock-ins using MiMIC transposonsSven Vilain
Department of Human Genetics and Leuven Research Institute for Neuroscience and Disease LIND, KU Leuven, 3000 Leuven, Belgium VIB Center for the Biology of disease, 3000 Leuven, Belgium
G3 (Bethesda) 4:2381-7. 2014..As a proof-of-principle, we mutated LRRK, tau, and sky by using different MiMIC elements...
- The TSC1/2 complex controls Drosophila pigmentation through TORC1-dependent regulation of catecholamine biosynthesisDiana Zitserman
Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
PLoS ONE 7:e48720. 2012....
- Differential effects of Tau on the integrity and function of neurons essential for learning in DrosophilaStylianos Kosmidis
Institute of Molecular Biology and Genetics, Biomedical Sciences Research Centre Alexander Fleming, Vari 16672, Greece
J Neurosci 30:464-77. 2010..dementias involving perturbations in the levels, phosphorylation, or mutations of the microtubule-binding protein Tau. The heterogeneous pathology in humans and model organisms suggests differential susceptibility of neuronal types ..
- The myriad roles of Miro in the nervous system: axonal transport of mitochondria and beyondKyu Sun Lee
Department of Pathology, Stanford University School of Medicine Stanford, CA, USA
Front Cell Neurosci 8:330. 2014....
- Drosophila spaghetti and doubletime link the circadian clock and light to caspases, apoptosis and tauopathyJohn C Means
Division of Molecular Biology and Biochemistry, School of Biological Sciences, University of Missouri Kansas City, Kansas City, Missouri, United States of America
PLoS Genet 11:e1005171. 2015..Furthermore, reduction of Dbt or Spag activity leads to Dronc-dependent Drosophila Tau cleavage and enhanced neurodegeneration produced by human Tau in a fly eye model for tauopathy...
- Modeling the complex pathology of Alzheimer's disease in DrosophilaPedro Fernandez-Funez
McKnight Brain Institute, Department of Neurology, University of Florida, Gainesville, FL 32611, USA Department of Neuroscience and Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32611, USA Genetics Institute, University of Florida, Gainesville, FL 32611, USA Electronic address
Exp Neurol 274:58-71. 2015..Neurofibrillary tangles enriched in tau are the other pathological hallmark of AD, but the lack of causative tau mutations still puzzles researchers...
- Quantitative characterization of adhesion and stiffness of corneal lens of Drosophila melanogaster using atomic force microscopyA L Lavanya Devi
Centre for Nanoscience and Engineering, Indian Institute of Science, Bangalore, Karnataka 560012, India Department of Mechanical Engineering, Indian Institute of Science, Bangalore, Karnataka 560012, India
J Mech Behav Biomed Mater 53:161-73. 2016..These properties are found to be different in corneal lens of eye expressing human mutant tau gene (mutant). The adhesion force, stiffness and elastic modulus are decreased in the mutant...
- Live imaging of muscles in Drosophila metamorphosis: Towards high-throughput gene identification and function analysisWee Choo Puah
Imaging Informatics Division, Bioinformatics Institute BII, Agency for Science, Technology and Research A STAR, 30 Biopolis Street, 07 01 Matrix, Singapore 138671, Republic of Singapore Electronic address
Methods 96:103-17. 2016..Finally, we discuss strategies to improve throughput of our pipeline to permit genome-wide screens in the future...
- Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal DegenerationErik G Gentry
Center for Neurodegeneration and Experimental Therapeutics and Departments of Neurology
J Neurosci 36:1316-23. 2016..Mitigating pathogenic tau levels is a rational strategy for tauopathy treatment, but therapeutic targets with clinically available drugs are ..
- Tau excess impairs mitosis and kinesin-5 function, leading to aneuploidy and cell deathAnne Laure Bouge
Department of Neurosciences, Institut de Genomique Fonctionnelle, CNRS UMR5203, Inserm U1191, Universite Montpellier, 141 rue de la Cardonille, Montpellier F 34094, Cedex 5, France
Dis Model Mech 9:307-19. 2016..mechanistic processes are largely unknown, in particular with respect to the microtubule (MT)-binding protein Tau, which is found in excess in the brain and cerebrospinal fluid of affected individuals...
- Deletion of endogenous Tau proteins is not detrimental in DrosophilaSylvie Burnouf
Max Planck Institute for Biology of Ageing, Joseph Stelzmann Strasse 9b, 50931 Cologne, Germany
Sci Rep 6:23102. 2016..As the fruit fly Drosophila melanogaster expresses Tau proteins (dTau) that are homologous to hTau, we aimed to better comprehend dTau functions by generating a specific tau knock-out (..
- Live imaging of muscle histolysis in Drosophila metamorphosisYadav Kuleesha
Imaging Informatics Division, Bioinformatics Institute BII, Agency for Science, Technology and Research A STAR, 30 Biopolis Street, 07 01 Matrix, Singapore, 138671, Republic of Singapore
BMC Dev Biol 16:12. 2016..Using live cell imaging of the abdomen, two groups of larval muscles can be observed, doomed muscles that undergo histolysis and persistent muscles that are remodelled and survive into adulthood...
- Patronin/Shot Cortical Foci Assemble the Noncentrosomal Microtubule Array that Specifies the Drosophila Anterior-Posterior AxisDmitry Nashchekin
The Gurdon Institute and the Department of Genetics, The University of Cambridge, Cambridge CB2 1QN, UK
Dev Cell 38:61-72. 2016..Thus, Shot/Patronin ncMTOCs may provide a general mechanism for organizing noncentrosomal microtubules in differentiated cells. ..
- Implicating calpain in tau-mediated toxicity in vivoJames B Reinecke
Department of Biology, Central Michigan University, Mount Pleasant, Michigan, United States of America
PLoS ONE 6:e23865. 2011..by the accumulation of abnormally phosphorylated and aggregated forms of the microtubule-associated protein tau. Several laboratories have identified a 17 kD proteolytic fragment of tau in degenerating neurons and in numerous ..
- HDAC6 mutations rescue human tau-induced microtubule defects in DrosophilaYing Xiong
Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
Proc Natl Acad Sci U S A 110:4604-9. 2013..disease (AD) and related tauopathy patients contain neurofibrillary tangles composed of hyperphosphorylated tau protein...
- Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1Kanae Iijima-Ando
Laboratory of Neurogenetics and Pathobiology, Department of Neuroscience, Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
PLoS Genet 8:e1002918. 2012Abnormal phosphorylation and toxicity of a microtubule-associated protein tau are involved in the pathogenesis of Alzheimer's disease (AD); however, what pathological conditions trigger tau abnormality in AD is not fully understood...
- The synaptic vesicle SNARE neuronal Synaptobrevin promotes endolysosomal degradation and prevents neurodegenerationAdam Haberman
Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
J Cell Biol 196:261-76. 2012..Our findings further shed light on which intraneuronal compartments exhibit increased or decreased neurotoxicity...
- Directed microtubule growth, +TIPs, and kinesin-2 are required for uniform microtubule polarity in dendritesFloyd J Mattie
Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA
Curr Biol 20:2169-77. 2010..Because undirected microtubule growth through dendrite branch points jeopardizes uniform microtubule polarity, we have used this system to understand how cells can maintain dynamic arrays of polarized microtubules...
- Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivoCatherine M Cowan
University of Southampton, UK
Acta Neuropathol 120:593-604. 2010It has been hypothesised that tau protein, when hyper-phosphorylated as in Alzheimer's disease (AD), does not bind effectively to microtubules and is no longer able to stabilise them; thus microtubules break down, and axonal transport ..
- Drosophila notal bristle as a novel assessment tool for pathogenic study of Tau toxicity and screening of therapeutic compoundsPo An Yeh
Department of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan, ROC
Biochem Biophys Res Commun 391:510-6. 2010To elucidate the Tau gain-of-toxicity functional mechanism and to search for potential treatments, we overexpressed human Tau variants (hTau) in the dorsal mesothorax (notum) of Drosophila...
- Microtubules are organized independently of the centrosome in Drosophila neuronsMichelle M Nguyen
Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA
Neural Dev 6:38. 2011..We use Drosophila as a model system to determine whether centrosomal microtubule nucleation is important in mature neurons...
- Phospho-dependent ubiquitination and degradation of PAR-1 regulates synaptic morphology and tau-mediated Aβ toxicity in DrosophilaSeongsoo Lee
Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
Nat Commun 3:1312. 2012..This newly identified PAR-1-modifying module critically regulates synaptic morphology and tau-mediated postsynaptic toxicity of amyloid precursor protein (APP)/Aβ-42, the causative agents of Alzheimer's ..
- Bazooka is required for localization of determinants and controlling proliferation in the sensory organ precursor cell lineage in DrosophilaF Roegiers
Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, CA 94143 0725, USA
Proc Natl Acad Sci U S A 98:14469-74. 2001..Bazooka also regulates cell proliferation in the SOP lineage; loss of bazooka function results in supernumerary cell divisions and apoptotic cell death...
- Asymmetric cell division: microtubule dynamics and spindle asymmetryJulia A Kaltschmidt
Wellcome Cancer Research UK Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
J Cell Sci 115:2257-64. 2002..In this commentary we discuss recent findings on how the mitotic spindle is positioned and on cleavage site induction and place them in the context of cell size asymmetry in different model organisms...
- Mechanisms of spindle positioning: focus on flies and wormsPIERRE GONCZY
Swiss Institute for Experimental Cancer Research ISREC, 155 ch des Boveresses, CH 1066 Epalinges Lausanne, Switzerland
Trends Cell Biol 12:332-9. 2002..This article discusses recent findings that indicate how this mechanism might be used for spindle positioning during Drosophila and Caenorhabditis elegans development...
- Disruption of the MAP1B-related protein FUTSCH leads to changes in the neuronal cytoskeleton, axonal transport defects, and progressive neurodegeneration in DrosophilaAlexandre Bettencourt Da Cruz
CROET Oregon Health and Science University, Portland, OR 97239, USA
Mol Biol Cell 16:2433-42. 2005..A similar effect is obtained by expression of either fly or bovine tau, suggesting a certain degree of functional redundancy of MAPs...
- Centrosome localization determines neuronal polarityFroylan Calderon de Anda
Cavalieri Ottolenghi Scientific Institute, Universita degli Studi di Torino, 10043 Orbassano, Torino, Italy
Nature 436:704-8. 2005..We conclude that asymmetric centrosome-mediated dynamics in the early post-mitotic stage instruct neuronal polarity, implying that pre-mitotic mechanisms with a role in division orientation may in turn participate in this event...
- Mutations in the Drosophila orthologs of the F-actin capping protein alpha- and beta-subunits cause actin accumulation and subsequent retinal degenerationIvana Delalle
Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
Genetics 171:1757-65. 2005..In its absence, cells progressively accumulate actin filaments and eventually die. A possible role for their human orthologs in neurodegenerative disease merits further investigation...
- Rapamycin alleviates toxicity of different aggregate-prone proteinsZdenek Berger
Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome MRC Building, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, UK
Hum Mol Genet 15:433-42. 2006..aggregate-prone proteins, including polyglutamine-expanded huntingtin in Huntington's disease (HD) and mutant tau in fronto-temporal dementia/tauopathy...
- Microtubules have opposite orientation in axons and dendrites of Drosophila neuronsMichelle C Stone
Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA
Mol Biol Cell 19:4122-9. 2008..As predicted by our map, endosomes travel smoothly between the cell body and axon, but they cannot move directly between the cell body and dendrites...
- Drosophila ensconsin promotes productive recruitment of Kinesin-1 to microtubulesHsin Ho Sung
Temasek Life Sciences Laboratory, 1 Research Link, The National University of Singapore, Singapore
Dev Cell 15:866-76. 2008..Furthermore, spatial control of motor recruitment can provide additional regulatory control in Par-1 and microtubule-dependent cell polarity...
- Par-1 and Tau regulate the anterior-posterior gradient of microtubules in Drosophila oocytesAi Guo Tian
Department of Biological Science, Florida State University, Tallahassee, FL 32306 4370, USA
Dev Biol 327:458-64. 2009..A phosphorylation target of Par-1, the microtubule-associated protein Tau, is also involved in oocyte polarity formation, and overexpression of Tau alleviates the phenotypes caused by ..
- Phosphorylation alters tau distribution and elongates life span in DrosophilaPo An Yeh
Institute of Biomedical Sciences, Academia Sinica, Nankang, Taipei, Taiwan
J Alzheimers Dis 21:543-56. 2010The microtubule-associated tau protein has long been considered an axon-specific protein...
- LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ßChin Hsien Lin
Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
J Neurosci 30:13138-49. 2010Intraneuronal tau aggregations are distinctive pathological features of Parkinson's disease (PD) with autosomal-dominant mutations in leucine-rich repeat kinase 2 (LRRK2)...
- NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathyYousuf O Ali
Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
Hum Mol Genet 21:237-50. 2012Tauopathies, including Alzheimer's disease, are a group of neurodegenerative diseases characterized by abnormal tau hyperphosphorylation that leads to formation of neurofibrillary tangles...