tau

Summary

Gene Symbol: tau
Description: CG45110 gene product from transcript CG45110-RH
Alias: BcDNA:RE16764, CG12881, CG31057, CG31058, CG34294, CG45110, CG5606, Dmel\CG45110, Dmel_CG31057, Dmel_CG31058, Dmel_CG34294, Tau, d-tau, dTau, dtau, CG45110 gene product from transcript CG45110-RH, CG45110-PA, CG45110-PB, CG45110-PC, CG45110-PE, CG45110-PF, CG45110-PG, CG45110-PH, CG45110-PI, CG45110-PJ, CG45110-PK, CG45110-PL, CG45110-PM, CG45110-PN, tau-PA, tau-PB, tau-PC, tau-PE, tau-PF, tau-PG, tau-PH, tau-PI, tau-PJ, tau-PK, tau-PL, tau-PM, tau-PN
Species: fruit fly

Top Publications

  1. ncbi Biochemical investigation of Tau protein phosphorylation status and its solubility properties in Drosophila
    Katy Wing Kam Chau
    Department of Biochemistry and Molecular Biotechnology Programme, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Biochem Biophys Res Commun 346:150-9. 2006
  2. ncbi TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model
    Vikram Khurana
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Harvard New Research Building Room 652, 77 Louis Pasteur Avenue, Boston, Massachusetts 02115, USA
    Curr Biol 16:230-41. 2006
  3. doi Drosophila models of human tauopathies indicate that Tau protein toxicity in vivo is mediated by soluble cytosolic phosphorylated forms of the protein
    Sébastien Feuillette
    INSERM U614, Rouen Institute for Medical Research, Faculty of Medicine, University of Rouen, Rouen Cedex, France
    J Neurochem 113:895-903. 2010
  4. pmc Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease
    Oyinkan Sofola
    Department of Genetics, Evolution, and Environment, Institute of Healthy Ageing and Research, University College London, London, United Kingdom
    PLoS Genet 6:e1001087. 2010
  5. pmc Tau phosphorylation sites work in concert to promote neurotoxicity in vivo
    Michelle L Steinhilb
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mol Biol Cell 18:5060-8. 2007
  6. ncbi A comparison of the neuronal dysfunction caused by Drosophila tau and human tau in a Drosophila model of tauopathies
    Kiren K Ubhi
    Department of Neuroscience, University of Southampton, School of Biological Sciences, Bassett Crescent East, Southampton, SO16 7PX, UK
    Invert Neurosci 7:165-71. 2007
  7. ncbi Study of tauopathies by comparing Drosophila and human tau in Drosophila
    Xinping Chen
    State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Cell Tissue Res 329:169-78. 2007
  8. ncbi Activation of PAR-1 kinase and stimulation of tau phosphorylation by diverse signals require the tumor suppressor protein LKB1
    Ji Wu Wang
    Department of Pathology, Stanford University School of Medicine, and Geriatric Research, Education, and Clinical Center Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    J Neurosci 27:574-81. 2007
  9. pmc DAPK activates MARK1/2 to regulate microtubule assembly, neuronal differentiation, and tau toxicity
    P R Wu
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    Cell Death Differ 18:1507-20. 2011
  10. ncbi Identification and characterization of the Drosophila tau homolog
    G Heidary
    Department of Genetics, University of Pennsylvania School of Medicine, Stellar Chance Laboratories 709C, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Mech Dev 108:171-8. 2001

Scientific Experts

  • Pedro Fernandez-Funez
  • Diego E Rincon-Limas
  • P GONCZY
  • Bingwei Lu
  • Po An Yeh
  • Wee Choo Puah
  • Michelle C Stone
  • Michelle L Steinhilb
  • Melissa M Rolls
  • Ji Wu Wang
  • Sylvie Burnouf
  • Erik G Gentry
  • Anne Laure Bouge
  • Dmitry Nashchekin
  • A L Lavanya Devi
  • Martin Wasser
  • Yadav Kuleesha
  • John C Means
  • Yan Ning Rui
  • Yunpeng Huang
  • Sven Vilain
  • Giulia Povellato
  • Gregory J Hoeprich
  • Kyu Sun Lee
  • Bonnie J Bolkan
  • Linda Partridge
  • Hong Ling Huang
  • Fiona Kerr
  • Jerrah K Holth
  • Hrvoje Augustin
  • Ying Xiong
  • Yousuf O Ali
  • Kanae Iijima-Ando
  • Diana Zitserman
  • Seongsoo Lee
  • Adam Haberman
  • Sujoy Ganguly
  • P R Wu
  • James B Reinecke
  • Michelle M Nguyen
  • Fabrice Roegiers
  • Sébastien Feuillette
  • Stylianos Kosmidis
  • Oyinkan Sofola
  • Chin Hsien Lin
  • Ju Yi Chien
  • Catherine M Cowan
  • Chiou Yang Tang
  • Floyd J Mattie
  • Ming Tsan Su
  • Doris Kretzschmar
  • Daniel St Johnston
  • Ai Guo Tian
  • David Shepherd
  • Amritpal Mudher
  • Hsin Ho Sung
  • Xinping Chen
  • Kiren K Ubhi
  • Efthimios M C Skoulakis
  • Mel B Feany
  • Zdenek Berger
  • Vikram Khurana
  • Katy Wing Kam Chau
  • Ivana Delalle
  • Froylan Calderon de Anda
  • Alexandre Bettencourt Da Cruz
  • Joshua M Shulman
  • Andreas Mershin
  • Isao Nishimura
  • M S Bobji
  • Marie Laure Parmentier
  • Artur Ribeiro Fernandes
  • Nicole C Riddle
  • Marianna Karina Gorsky
  • Nazif Alic
  • Jeremy H Herskowitz
  • Yangbo Feng
  • Hélène Doerflinger
  • Upendra Nongthomba
  • Pedro Martinez
  • Jennifer Werner
  • Jacqueline Dols
  • Andrew E Arrant
  • Benjamin W Henderson
  • Sebastian Gronke
  • Marla Gearing
  • Ana Maria Cuervo
  • Edward S Bjes
  • Anandakrishnan Venkatesan
  • Zhen Xu

Detail Information

Publications58

  1. ncbi Biochemical investigation of Tau protein phosphorylation status and its solubility properties in Drosophila
    Katy Wing Kam Chau
    Department of Biochemistry and Molecular Biotechnology Programme, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Biochem Biophys Res Commun 346:150-9. 2006
    b>Tau hyperphosphorylation and insoluble aggregate formation are two cellular features of tauopathies. However, the contribution of Tau protein hyperphosphorylation and its aggregation to Tau pathology still remain controversial...
  2. ncbi TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model
    Vikram Khurana
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Harvard New Research Building Room 652, 77 Louis Pasteur Avenue, Boston, Massachusetts 02115, USA
    Curr Biol 16:230-41. 2006
    ..However, the critical questions of whether cell-cycle activation is causal or epiphenomenal to tau-induced neurodegeneration and which signaling pathways mediate cell-cycle activation in tauopathy remain unresolved.
  3. doi Drosophila models of human tauopathies indicate that Tau protein toxicity in vivo is mediated by soluble cytosolic phosphorylated forms of the protein
    Sébastien Feuillette
    INSERM U614, Rouen Institute for Medical Research, Faculty of Medicine, University of Rouen, Rouen Cedex, France
    J Neurochem 113:895-903. 2010
    b>Tau is a neuronal microtubule-associated protein involved in microtubules assembly and stabilization...
  4. pmc Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease
    Oyinkan Sofola
    Department of Genetics, Evolution, and Environment, Institute of Healthy Ageing and Research, University College London, London, United Kingdom
    PLoS Genet 6:e1001087. 2010
    ..pathogenesis of Alzheimer's disease (AD), with downstream neurotoxic effects including the hyperphosphorylation of tau protein...
  5. pmc Tau phosphorylation sites work in concert to promote neurotoxicity in vivo
    Michelle L Steinhilb
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mol Biol Cell 18:5060-8. 2007
    b>Tau is a microtubule binding protein implicated in a number of human neurodegenerative disorders, including Alzheimer's disease...
  6. ncbi A comparison of the neuronal dysfunction caused by Drosophila tau and human tau in a Drosophila model of tauopathies
    Kiren K Ubhi
    Department of Neuroscience, University of Southampton, School of Biological Sciences, Bassett Crescent East, Southampton, SO16 7PX, UK
    Invert Neurosci 7:165-71. 2007
    Hyperphosphorylation and aggregation of tau into tangles is a feature of disorders such as Alzheimer's disease and other Tauopathies...
  7. ncbi Study of tauopathies by comparing Drosophila and human tau in Drosophila
    Xinping Chen
    State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Cell Tissue Res 329:169-78. 2007
    The microtubule-binding protein tau has been investigated for its contribution to various neurodegenerative disorders. However, the findings from transgenic studies, using the same tau transgene, vary widely among different laboratories...
  8. ncbi Activation of PAR-1 kinase and stimulation of tau phosphorylation by diverse signals require the tumor suppressor protein LKB1
    Ji Wu Wang
    Department of Pathology, Stanford University School of Medicine, and Geriatric Research, Education, and Clinical Center Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    J Neurosci 27:574-81. 2007
    Aberrant phosphorylation of tau is associated with a number of neurodegenerative diseases, including Alzheimer's disease (AD)...
  9. pmc DAPK activates MARK1/2 to regulate microtubule assembly, neuronal differentiation, and tau toxicity
    P R Wu
    Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
    Cell Death Differ 18:1507-20. 2011
    ..microtubule (MT) assembly by activating MARK/PAR-1 family kinases MARK1/2, which destabilize MT by phosphorylating tau and related MAP2/4...
  10. ncbi Identification and characterization of the Drosophila tau homolog
    G Heidary
    Department of Genetics, University of Pennsylvania School of Medicine, Stellar Chance Laboratories 709C, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Mech Dev 108:171-8. 2001
    ..The principal component of these structures is the microtubule-associated protein tau. Although tau is normally a highly soluble protein enriched in axons, in these deposits, it is abnormally ..
  11. pmc Learning and memory deficits upon TAU accumulation in Drosophila mushroom body neurons
    Andreas Mershin
    Department of Physics and Department of Biology, Texas A and M University, College Station, Texas 77843, USA
    Learn Mem 11:277-87. 2004
    Mutations in the neuronal-specific microtubule-binding protein TAU are associated with several dementias and neurodegenerative diseases. However, the effects of elevated TAU accumulation on behavioral plasticity are unknown...
  12. ncbi PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila
    Isao Nishimura
    Laboratory of Developmental Neurobiology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Cell 116:671-82. 2004
    Multisite hyperphosphorylation of tau has been implicated in the pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD)...
  13. ncbi The role of PAR-1 in regulating the polarised microtubule cytoskeleton in the Drosophila follicular epithelium
    Hélène Doerflinger
    The Wellcome Trust Cancer Research UK Institute and the Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Development 130:3965-75. 2003
    ..The MARKs have been proposed to destabilize microtubules by inhibiting the stabilizing activity of the Tau family of microtubule-associated proteins...
  14. pmc Modification of the Drosophila model of in vivo Tau toxicity reveals protective phosphorylation by GSK3β
    Giulia Povellato
    MRC Centre for Developmental Neurobiology, King s College London, New Hunt s House, Guy s Hospital Campus, London SE1 1UL, UK
    Biol Open 3:1-11. 2014
    Hyperphosphorylation of the microtubule associated protein, Tau, is the hallmark of a group of neurodegenerative disorders known as the tauopathies which includes Alzheimer's disease...
  15. pmc Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association
    Hong Ling Huang
    State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P R China
    PLoS Biol 11:e1001620. 2013
    ..Furthermore, we provided evidence that Par-1-induced Hpo regulation is conserved in mammalian cells. Taken together, our findings identified Par-1 as a novel component of the Hpo signaling network. ..
  16. pmc Huntingtin functions as a scaffold for selective macroautophagy
    Yan Ning Rui
    The Brown Foundation Institute of Molecular Medicine, The University of Texas Medical School at Houston, The University of Texas Health Science Center at Houston UTHealth, 1825 Pressler Street Houston, Texas 77030, USA
    Nat Cell Biol 17:262-75. 2015
    ..Our data uncover an important physiological function of Huntingtin and provide a missing link in the activation of selective macroautophagy in metazoans. ..
  17. pmc Drosophila models of proteinopathies: the little fly that could
    Diego E Rincon-Limas
    Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, FL 32610 0236, USA
    Curr Pharm Des 18:1108-22. 2012
    ..To remain relevant in this competitive environment, Drosophila models will need to expand their flexible, innovative, and multidisciplinary approaches to find new discoveries and translational applications...
  18. pmc Cytoplasmic streaming in Drosophila oocytes varies with kinesin activity and correlates with the microtubule cytoskeleton architecture
    Sujoy Ganguly
    Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, United Kingdom
    Proc Natl Acad Sci U S A 109:15109-14. 2012
    ....
  19. pmc Kinesin's neck-linker determines its ability to navigate obstacles on the microtubule surface
    Gregory J Hoeprich
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont
    Biophys J 106:1691-700. 2014
    ..kinesin-1 and kinesin-2 neck-linker chimeras stepping along microtubules in the absence or presence of two Tau isoforms, 3RS-Tau and 4RL-Tau, both of which are MAPs that are known to differentially affect kinesin-1 motility...
  20. pmc Loss of Tau results in defects in photoreceptor development and progressive neuronal degeneration in Drosophila
    Bonnie J Bolkan
    Oregon Institute of Occupational Health Sciences, Oregon Health and Science University, Portland, Oregon, 97239
    Dev Neurobiol 74:1210-25. 2014
    ..Reducing the levels of fly Tau (dTau) ubiquitously resulted in developmental lethality, whereas deleting Tau specifically in neurons or the eye caused ..
  21. pmc Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy
    Jerrah K Holth
    Developmental Neurogenetics Laboratory, Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 33:1651-9. 2013
    ..Recently, the microtubule-binding protein tau has been implicated in the regulation of network synchronization...
  22. pmc Zinc binding directly regulates tau toxicity independent of tau hyperphosphorylation
    Yunpeng Huang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China
    Cell Rep 8:831-42. 2014
    b>Tau hyperphosphorylation is thought to underlie tauopathy...
  23. pmc Fast and efficient Drosophila melanogaster gene knock-ins using MiMIC transposons
    Sven Vilain
    Department of Human Genetics and Leuven Research Institute for Neuroscience and Disease LIND, KU Leuven, 3000 Leuven, Belgium VIB Center for the Biology of disease, 3000 Leuven, Belgium
    G3 (Bethesda) 4:2381-7. 2014
    ..As a proof-of-principle, we mutated LRRK, tau, and sky by using different MiMIC elements...
  24. pmc The TSC1/2 complex controls Drosophila pigmentation through TORC1-dependent regulation of catecholamine biosynthesis
    Diana Zitserman
    Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e48720. 2012
    ....
  25. doi Differential effects of Tau on the integrity and function of neurons essential for learning in Drosophila
    Stylianos Kosmidis
    Institute of Molecular Biology and Genetics, Biomedical Sciences Research Centre Alexander Fleming, Vari 16672, Greece
    J Neurosci 30:464-77. 2010
    ..dementias involving perturbations in the levels, phosphorylation, or mutations of the microtubule-binding protein Tau. The heterogeneous pathology in humans and model organisms suggests differential susceptibility of neuronal types ..
  26. pmc The myriad roles of Miro in the nervous system: axonal transport of mitochondria and beyond
    Kyu Sun Lee
    Department of Pathology, Stanford University School of Medicine Stanford, CA, USA
    Front Cell Neurosci 8:330. 2014
    ....
  27. pmc Drosophila spaghetti and doubletime link the circadian clock and light to caspases, apoptosis and tauopathy
    John C Means
    Division of Molecular Biology and Biochemistry, School of Biological Sciences, University of Missouri Kansas City, Kansas City, Missouri, United States of America
    PLoS Genet 11:e1005171. 2015
    ..Furthermore, reduction of Dbt or Spag activity leads to Dronc-dependent Drosophila Tau cleavage and enhanced neurodegeneration produced by human Tau in a fly eye model for tauopathy...
  28. pmc Modeling the complex pathology of Alzheimer's disease in Drosophila
    Pedro Fernandez-Funez
    McKnight Brain Institute, Department of Neurology, University of Florida, Gainesville, FL 32611, USA Department of Neuroscience and Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32611, USA Genetics Institute, University of Florida, Gainesville, FL 32611, USA Electronic address
    Exp Neurol 274:58-71. 2015
    ..Neurofibrillary tangles enriched in tau are the other pathological hallmark of AD, but the lack of causative tau mutations still puzzles researchers...
  29. doi Quantitative characterization of adhesion and stiffness of corneal lens of Drosophila melanogaster using atomic force microscopy
    A L Lavanya Devi
    Centre for Nanoscience and Engineering, Indian Institute of Science, Bangalore, Karnataka 560012, India Department of Mechanical Engineering, Indian Institute of Science, Bangalore, Karnataka 560012, India
    J Mech Behav Biomed Mater 53:161-73. 2016
    ..These properties are found to be different in corneal lens of eye expressing human mutant tau gene (mutant). The adhesion force, stiffness and elastic modulus are decreased in the mutant...
  30. doi Live imaging of muscles in Drosophila metamorphosis: Towards high-throughput gene identification and function analysis
    Wee Choo Puah
    Imaging Informatics Division, Bioinformatics Institute BII, Agency for Science, Technology and Research A STAR, 30 Biopolis Street, 07 01 Matrix, Singapore 138671, Republic of Singapore Electronic address
    Methods 96:103-17. 2016
    ..Finally, we discuss strategies to improve throughput of our pipeline to permit genome-wide screens in the future...
  31. pmc Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration
    Erik G Gentry
    Center for Neurodegeneration and Experimental Therapeutics and Departments of Neurology
    J Neurosci 36:1316-23. 2016
    ..Mitigating pathogenic tau levels is a rational strategy for tauopathy treatment, but therapeutic targets with clinically available drugs are ..
  32. pmc Tau excess impairs mitosis and kinesin-5 function, leading to aneuploidy and cell death
    Anne Laure Bouge
    Department of Neurosciences, Institut de Genomique Fonctionnelle, CNRS UMR5203, Inserm U1191, Universite Montpellier, 141 rue de la Cardonille, Montpellier F 34094, Cedex 5, France
    Dis Model Mech 9:307-19. 2016
    ..mechanistic processes are largely unknown, in particular with respect to the microtubule (MT)-binding protein Tau, which is found in excess in the brain and cerebrospinal fluid of affected individuals...
  33. pmc Deletion of endogenous Tau proteins is not detrimental in Drosophila
    Sylvie Burnouf
    Max Planck Institute for Biology of Ageing, Joseph Stelzmann Strasse 9b, 50931 Cologne, Germany
    Sci Rep 6:23102. 2016
    ..As the fruit fly Drosophila melanogaster expresses Tau proteins (dTau) that are homologous to hTau, we aimed to better comprehend dTau functions by generating a specific tau knock-out (..
  34. pmc Live imaging of muscle histolysis in Drosophila metamorphosis
    Yadav Kuleesha
    Imaging Informatics Division, Bioinformatics Institute BII, Agency for Science, Technology and Research A STAR, 30 Biopolis Street, 07 01 Matrix, Singapore, 138671, Republic of Singapore
    BMC Dev Biol 16:12. 2016
    ..Using live cell imaging of the abdomen, two groups of larval muscles can be observed, doomed muscles that undergo histolysis and persistent muscles that are remodelled and survive into adulthood...
  35. pmc Patronin/Shot Cortical Foci Assemble the Noncentrosomal Microtubule Array that Specifies the Drosophila Anterior-Posterior Axis
    Dmitry Nashchekin
    The Gurdon Institute and the Department of Genetics, The University of Cambridge, Cambridge CB2 1QN, UK
    Dev Cell 38:61-72. 2016
    ..Thus, Shot/Patronin ncMTOCs may provide a general mechanism for organizing noncentrosomal microtubules in differentiated cells. ..
  36. pmc Implicating calpain in tau-mediated toxicity in vivo
    James B Reinecke
    Department of Biology, Central Michigan University, Mount Pleasant, Michigan, United States of America
    PLoS ONE 6:e23865. 2011
    ..by the accumulation of abnormally phosphorylated and aggregated forms of the microtubule-associated protein tau. Several laboratories have identified a 17 kD proteolytic fragment of tau in degenerating neurons and in numerous ..
  37. pmc HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila
    Ying Xiong
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Proc Natl Acad Sci U S A 110:4604-9. 2013
    ..disease (AD) and related tauopathy patients contain neurofibrillary tangles composed of hyperphosphorylated tau protein...
  38. pmc Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1
    Kanae Iijima-Ando
    Laboratory of Neurogenetics and Pathobiology, Department of Neuroscience, Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 8:e1002918. 2012
    Abnormal phosphorylation and toxicity of a microtubule-associated protein tau are involved in the pathogenesis of Alzheimer's disease (AD); however, what pathological conditions trigger tau abnormality in AD is not fully understood...
  39. pmc The synaptic vesicle SNARE neuronal Synaptobrevin promotes endolysosomal degradation and prevents neurodegeneration
    Adam Haberman
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Cell Biol 196:261-76. 2012
    ..Our findings further shed light on which intraneuronal compartments exhibit increased or decreased neurotoxicity...
  40. pmc Directed microtubule growth, +TIPs, and kinesin-2 are required for uniform microtubule polarity in dendrites
    Floyd J Mattie
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA
    Curr Biol 20:2169-77. 2010
    ..Because undirected microtubule growth through dendrite branch points jeopardizes uniform microtubule polarity, we have used this system to understand how cells can maintain dynamic arrays of polarized microtubules...
  41. doi Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo
    Catherine M Cowan
    University of Southampton, UK
    Acta Neuropathol 120:593-604. 2010
    It has been hypothesised that tau protein, when hyper-phosphorylated as in Alzheimer's disease (AD), does not bind effectively to microtubules and is no longer able to stabilise them; thus microtubules break down, and axonal transport ..
  42. doi Drosophila notal bristle as a novel assessment tool for pathogenic study of Tau toxicity and screening of therapeutic compounds
    Po An Yeh
    Department of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan, ROC
    Biochem Biophys Res Commun 391:510-6. 2010
    To elucidate the Tau gain-of-toxicity functional mechanism and to search for potential treatments, we overexpressed human Tau variants (hTau) in the dorsal mesothorax (notum) of Drosophila...
  43. pmc Microtubules are organized independently of the centrosome in Drosophila neurons
    Michelle M Nguyen
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA
    Neural Dev 6:38. 2011
    ..We use Drosophila as a model system to determine whether centrosomal microtubule nucleation is important in mature neurons...
  44. pmc Phospho-dependent ubiquitination and degradation of PAR-1 regulates synaptic morphology and tau-mediated Aβ toxicity in Drosophila
    Seongsoo Lee
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Commun 3:1312. 2012
    ..This newly identified PAR-1-modifying module critically regulates synaptic morphology and tau-mediated postsynaptic toxicity of amyloid precursor protein (APP)/Aβ-42, the causative agents of Alzheimer's ..
  45. pmc Bazooka is required for localization of determinants and controlling proliferation in the sensory organ precursor cell lineage in Drosophila
    F Roegiers
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, CA 94143 0725, USA
    Proc Natl Acad Sci U S A 98:14469-74. 2001
    ..Bazooka also regulates cell proliferation in the SOP lineage; loss of bazooka function results in supernumerary cell divisions and apoptotic cell death...
  46. ncbi Asymmetric cell division: microtubule dynamics and spindle asymmetry
    Julia A Kaltschmidt
    Wellcome Cancer Research UK Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    J Cell Sci 115:2257-64. 2002
    ..In this commentary we discuss recent findings on how the mitotic spindle is positioned and on cleavage site induction and place them in the context of cell size asymmetry in different model organisms...
  47. ncbi Mechanisms of spindle positioning: focus on flies and worms
    PIERRE GONCZY
    Swiss Institute for Experimental Cancer Research ISREC, 155 ch des Boveresses, CH 1066 Epalinges Lausanne, Switzerland
    Trends Cell Biol 12:332-9. 2002
    ..This article discusses recent findings that indicate how this mechanism might be used for spindle positioning during Drosophila and Caenorhabditis elegans development...
  48. pmc Disruption of the MAP1B-related protein FUTSCH leads to changes in the neuronal cytoskeleton, axonal transport defects, and progressive neurodegeneration in Drosophila
    Alexandre Bettencourt Da Cruz
    CROET Oregon Health and Science University, Portland, OR 97239, USA
    Mol Biol Cell 16:2433-42. 2005
    ..A similar effect is obtained by expression of either fly or bovine tau, suggesting a certain degree of functional redundancy of MAPs...
  49. ncbi Centrosome localization determines neuronal polarity
    Froylan Calderon de Anda
    Cavalieri Ottolenghi Scientific Institute, Universita degli Studi di Torino, 10043 Orbassano, Torino, Italy
    Nature 436:704-8. 2005
    ..We conclude that asymmetric centrosome-mediated dynamics in the early post-mitotic stage instruct neuronal polarity, implying that pre-mitotic mechanisms with a role in division orientation may in turn participate in this event...
  50. pmc Mutations in the Drosophila orthologs of the F-actin capping protein alpha- and beta-subunits cause actin accumulation and subsequent retinal degeneration
    Ivana Delalle
    Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
    Genetics 171:1757-65. 2005
    ..In its absence, cells progressively accumulate actin filaments and eventually die. A possible role for their human orthologs in neurodegenerative disease merits further investigation...
  51. ncbi Rapamycin alleviates toxicity of different aggregate-prone proteins
    Zdenek Berger
    Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome MRC Building, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, UK
    Hum Mol Genet 15:433-42. 2006
    ..aggregate-prone proteins, including polyglutamine-expanded huntingtin in Huntington's disease (HD) and mutant tau in fronto-temporal dementia/tauopathy...
  52. pmc Microtubules have opposite orientation in axons and dendrites of Drosophila neurons
    Michelle C Stone
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA
    Mol Biol Cell 19:4122-9. 2008
    ..As predicted by our map, endosomes travel smoothly between the cell body and axon, but they cannot move directly between the cell body and dendrites...
  53. doi Drosophila ensconsin promotes productive recruitment of Kinesin-1 to microtubules
    Hsin Ho Sung
    Temasek Life Sciences Laboratory, 1 Research Link, The National University of Singapore, Singapore
    Dev Cell 15:866-76. 2008
    ..Furthermore, spatial control of motor recruitment can provide additional regulatory control in Par-1 and microtubule-dependent cell polarity...
  54. pmc Par-1 and Tau regulate the anterior-posterior gradient of microtubules in Drosophila oocytes
    Ai Guo Tian
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4370, USA
    Dev Biol 327:458-64. 2009
    ..A phosphorylation target of Par-1, the microtubule-associated protein Tau, is also involved in oocyte polarity formation, and overexpression of Tau alleviates the phenotypes caused by ..
  55. doi Phosphorylation alters tau distribution and elongates life span in Drosophila
    Po An Yeh
    Institute of Biomedical Sciences, Academia Sinica, Nankang, Taipei, Taiwan
    J Alzheimers Dis 21:543-56. 2010
    The microtubule-associated tau protein has long been considered an axon-specific protein...
  56. doi LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ß
    Chin Hsien Lin
    Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
    J Neurosci 30:13138-49. 2010
    Intraneuronal tau aggregations are distinctive pathological features of Parkinson's disease (PD) with autosomal-dominant mutations in leucine-rich repeat kinase 2 (LRRK2)...
  57. pmc NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy
    Yousuf O Ali
    Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Hum Mol Genet 21:237-50. 2012
    Tauopathies, including Alzheimer's disease, are a group of neurodegenerative diseases characterized by abnormal tau hyperphosphorylation that leads to formation of neurofibrillary tangles...