srp

Summary

Gene Symbol: srp
Description: serpent
Alias: A7.1, ABF, Abf, CG3992, DmGATAb, Dmel\CG3992, GATA, GATAb, SRP, Srp, abf, dGATAb, l(3)01549, l(3)89B2, l(3)neo45, spt, srpD, CG3992 gene product from transcript CG3992-RE, A-box-binding factor, CG3992-PA, CG3992-PB, CG3992-PD, CG3992-PE, CG3992-PF, CG3992-PG, serpentD, srp-PA, srp-PB, srp-PD, srp-PE, srp-PF, srp-PG
Species: fruit fly

Top Publications

  1. ncbi The role of fs(1)K10 in the localization of the mRNA of the TGF alpha homolog gurken within the Drosophila oocyte
    T L Serano
    Department of Biochemistry, University of Kansas, Lawrence 66045, USA
    Mech Dev 51:183-92. 1995
  2. pmc Down-regulation of NF-kappaB target genes by the AP-1 and STAT complex during the innate immune response in Drosophila
    Lark Kyun Kim
    Department of Biochemistry, National Creative Research Initiative Center for Genome Regulation, Yonsei University, Seoul, Korea
    PLoS Biol 5:e238. 2007
  3. ncbi Expression of a Drosophila GATA transcription factor in multiple tissues in the developing embryos. Identification of homozygous lethal mutants with P-element insertion at the promoter region
    W H Lin
    Institute of Genetics, National Yang Ming University, Taipei, Taiwan, Republic of China
    J Biol Chem 270:25150-8. 1995
  4. ncbi A Drosophila GATA family member that binds to Adh regulatory sequences is expressed in the developing fat body
    T Abel
    Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138
    Development 119:623-33. 1993
  5. ncbi A group of genes required for maintenance of the amnioserosa tissue in Drosophila
    L H Frank
    Department of Biology, New York University, NY 10003, USA
    Development 122:1343-52. 1996
  6. ncbi A molecular aspect of hematopoiesis and endoderm development common to vertebrates and Drosophila
    K P Rehorn
    Institut fur Genetik, Universitat zu Koln, Germany
    Development 122:4023-31. 1996
  7. ncbi The serpent gene is necessary for progression through the early stages of fat-body development
    S Sam
    Department of Biological Sciences, University of Nevada at Las Vegas 89154 4004, USA
    Mech Dev 60:197-205. 1996
  8. ncbi The genetic control of the distinction between fat body and gonadal mesoderm in Drosophila
    V Riechmann
    Institut fur Genetik, Universitat zu Koln, D 50931 Köln, Germany
    Development 125:713-23. 1998
  9. ncbi Gonadal mesoderm and fat body initially follow a common developmental path in Drosophila
    L A Moore
    Skirball Institute, New York University Medical Center, NY, NY 10016, USA
    Development 125:837-44. 1998
  10. pmc Serpent regulates Drosophila immunity genes in the larval fat body through an essential GATA motif
    U M Petersen
    Department of Molecular Biology, Arrhenius Laboratories for Natural Sciences, Stockholm University, S 106 91 Stockholm, Sweden
    EMBO J 18:4013-22. 1999

Scientific Experts

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Detail Information

Publications101 found, 100 shown here

  1. ncbi The role of fs(1)K10 in the localization of the mRNA of the TGF alpha homolog gurken within the Drosophila oocyte
    T L Serano
    Department of Biochemistry, University of Kansas, Lawrence 66045, USA
    Mech Dev 51:183-92. 1995
    ..From this and other data, we propose a more direct role for fs(1)K10 in the gurken mRNA localization process...
  2. pmc Down-regulation of NF-kappaB target genes by the AP-1 and STAT complex during the innate immune response in Drosophila
    Lark Kyun Kim
    Department of Biochemistry, National Creative Research Initiative Center for Genome Regulation, Yonsei University, Seoul, Korea
    PLoS Biol 5:e238. 2007
    ..We conclude that an inhibitory effect of AP-1 and STAT on NF-kappaB is required for properly balanced immune responses and appears to be evolutionarily conserved...
  3. ncbi Expression of a Drosophila GATA transcription factor in multiple tissues in the developing embryos. Identification of homozygous lethal mutants with P-element insertion at the promoter region
    W H Lin
    Institute of Genetics, National Yang Ming University, Taipei, Taiwan, Republic of China
    J Biol Chem 270:25150-8. 1995
    b>GATA transcription factors are DNA-binding proteins that recognize the core consensus sequence, WGATAR. Previous studies indicated that GATA factors play ann important role in the development of tissue-specific functions in vertebrates...
  4. ncbi A Drosophila GATA family member that binds to Adh regulatory sequences is expressed in the developing fat body
    T Abel
    Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138
    Development 119:623-33. 1993
    ..analysis of cDNA clones encoding this protein, box A-binding factor (ABF), reveals that it is a member of the GATA family of transcriptional regulatory factors. ABF-binding sites within the D. mulleri and D...
  5. ncbi A group of genes required for maintenance of the amnioserosa tissue in Drosophila
    L H Frank
    Department of Biology, New York University, NY 10003, USA
    Development 122:1343-52. 1996
    ..markers, we examined amnioserosa development in the ush-group mutants: u-shaped (ush), hindsight (hnt), serpent (srp) and tail-up (tup)...
  6. ncbi A molecular aspect of hematopoiesis and endoderm development common to vertebrates and Drosophila
    K P Rehorn
    Institut fur Genetik, Universitat zu Koln, Germany
    Development 122:4023-31. 1996
    In vertebrates, transcriptional regulators of the GATA family appear to have a conserved function in differentiation and organ development...
  7. ncbi The serpent gene is necessary for progression through the early stages of fat-body development
    S Sam
    Department of Biological Sciences, University of Nevada at Las Vegas 89154 4004, USA
    Mech Dev 60:197-205. 1996
    The serpent (srp) gene, also known as ABF, codes for a GATA-like transcription factor and is involved in the transcription activation of Adh in the larval fat body or adipose tissue...
  8. ncbi The genetic control of the distinction between fat body and gonadal mesoderm in Drosophila
    V Riechmann
    Institut fur Genetik, Universitat zu Koln, D 50931 Köln, Germany
    Development 125:713-23. 1998
    ..The homeotic gene abdominalA limits the region of serpent activity by interfering in a mutually repressive feed back loop between gonadal and fat body development...
  9. ncbi Gonadal mesoderm and fat body initially follow a common developmental path in Drosophila
    L A Moore
    Skirball Institute, New York University Medical Center, NY, NY 10016, USA
    Development 125:837-44. 1998
    ..mesoderm along the anteroposterior axis is determined by the combined actions of genes including abdA, AbdB and srp; while srp promotes fat body development, abdA allows gonadal mesoderm to develop by repressing srp function...
  10. pmc Serpent regulates Drosophila immunity genes in the larval fat body through an essential GATA motif
    U M Petersen
    Department of Molecular Biology, Arrhenius Laboratories for Natural Sciences, Stockholm University, S 106 91 Stockholm, Sweden
    EMBO J 18:4013-22. 1999
    ..The regulatory regions of many immunity genes contain a GATA motif in proximity to a kappaB motif...
  11. ncbi Functions for Drosophila brachyenteron and forkhead in mesoderm specification and cell signalling
    T Kusch
    Institut fur Genetik, Universitat zu Koln, Weyertal 121, D 50931 Köln, Germany
    Development 126:3991-4003. 1999
    ..We propose that the functions of brachyenteron in mesodermal development of Drosophila are comparable to the roles of the vertebrate Brachyury genes during gastrulation...
  12. ncbi Specification of Drosophila hematopoietic lineage by conserved transcription factors
    T Lebestky
    Molecular Biology Institute, Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Science 288:146-9. 2000
    ..Misexpression of Gcm causes crystal cells to be transformed into plasmatocytes. The Drosophila GATA protein Srp (Serpent) is required for both Lz and Gcm expression and is necessary for the development of both ..
  13. ncbi serpent, a GATA-like transcription factor gene, induces fat-cell development in Drosophila melanogaster
    S A Hayes
    Department of Biological Sciences, University of Nevada, Las Vegas, Box 454004, Las Vegas, Nevada 89154 4004, USA
    Development 128:1193-200. 2001
    The GATA-like transcription factor gene serpent is necessary for embryonic fat-cell differentiation in Drosophila (Sam, S., Leise, W. and Hoshizaki, D. K. (1996) Mech. Dev...
  14. pmc The GATA factor Serpent is required for the onset of the humoral immune response in Drosophila embryos
    T O Tingvall
    Department of Molecular Biology and Functional Genomics, Arrhenius Laboratories for Natural Sciences, Stockholm University, S 106 91 Stockholm, Sweden
    Proc Natl Acad Sci U S A 98:3884-8. 2001
    ..of a GATA site in the promoter as well as the involvement of the GATA-binding transcription factor Serpent (dGATAb). In contrast, neither the GATA site nor Serpent were necessary for Cecropin expression in the epidermis...
  15. pmc The Friend of GATA proteins U-shaped, FOG-1, and FOG-2 function as negative regulators of blood, heart, and eye development in Drosophila
    N Fossett
    Department of Biochemistry and Molecular Biology, Graduate Program in Genes and Development, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 98:7342-7. 2001
    Friend of GATA (FOG) proteins regulate GATA factor-activated gene transcription. During vertebrate hematopoiesis, FOG and GATA proteins cooperate to promote erythrocyte and megakaryocyte differentiation...
  16. pmc Specific tracheal migration is mediated by complementary expression of cell surface proteins
    M Boube
    Institut de Biologia de Biologia Molecular de Barcelona CSIC, 08034 Barcelona, Spain
    Genes Dev 15:1554-62. 2001
    ....
  17. ncbi Functional conservation of hematopoietic factors in Drosophila and vertebrates
    N Fossett
    Department of Biochemistry and Molecular Biology, Graduate Program in Genes and Development, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Differentiation 69:83-90. 2001
    The GATA, Friend of GATA, and Runt homology domain protein families function during hematopoiesis to promote progenitor cell development and regulate lineage commitment and differentiation...
  18. ncbi Developmental control of blood cell migration by the Drosophila VEGF pathway
    Nam K Cho
    Howard Hughes Medical Institute, Department of Biochemistry, Stanford University, Stanford, CA 94305, USA
    Cell 108:865-76. 2002
    ..The results suggest that the Drosophila VEGF pathway guides developmental migrations of blood cells, and we speculate that the ancestral function of VEGF pathways was to guide blood cell movement...
  19. pmc Two isoforms of Serpent containing either one or two GATA zinc fingers have different roles in Drosophila haematopoiesis
    Lucas Waltzer
    Centre de Biologie du Développement CNRS, 31062 Toulouse, France
    EMBO J 21:5477-86. 2002
    serpent (srp) encodes a GATA transcription factor essential for haematopoiesis in Drosophila. Previously, Srp was shown to contain a single GATA zinc finger of C-terminal type...
  20. ncbi Notch signaling controls lineage specification during Drosophila larval hematopoiesis
    Bernard Duvic
    Unité Propre de Recherche 9022, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, 67084, Strasbourg, France
    Curr Biol 12:1923-7. 2002
    ..Finally, Notch does not appear to play a role in the differentiation of the plasmatocyte lineage. This study underlines the existence of parallels in the genetic control of hematopoiesis in Drosophila and in mammals...
  21. pmc A Serrate-expressing signaling center controls Drosophila hematopoiesis
    Tim Lebestky
    Molecular Biology Institute, University of California Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 17:348-53. 2003
    The differentiation of Drosophila blood cells relies on a functional hierarchy between the GATA protein, Serpent (Srp), and multiple lineage-specific transcription factors, such as the AML1-like protein, Lozenge (Lz)...
  22. ncbi Drosophila asrij is expressed in pole cells, trachea and hemocytes
    Maneesha S Inamdar
    Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, 560 064, Bangalore, India
    Dev Genes Evol 213:134-7. 2003
    ..Expression in the blood-cell lineage precedes that of known hematopoietic transcription factors. These results suggest that Drosophila asrij functions in the hematopoietic lineage...
  23. pmc Combinatorial interactions of serpent, lozenge, and U-shaped regulate crystal cell lineage commitment during Drosophila hematopoiesis
    Nancy Fossett
    Department of Biochemistry and Molecular Biology, Graduate Program in Genes and Development, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:11451-6. 2003
    The GATA factor Serpent (Srp) is required for hemocyte precursor formation during Drosophila hematopoiesis. These blood cell progenitors give rise to two distinct lineages within the developing embryo...
  24. pmc Cooperation between the GATA and RUNX factors Serpent and Lozenge during Drosophila hematopoiesis
    Lucas Waltzer
    Centre de Biologie du Developpement, CNRS UMR 5547, 118 route de Narbonne, 31062 Toulouse, France
    EMBO J 22:6516-25. 2003
    Members of the GATA and RUNX families of genes appear to have conserved functions during hematopoiesis from Drosophila to mammals...
  25. ncbi Immunity regulatory DNAs share common organizational features in Drosophila
    Kate Senger
    Department of Molecular and Cellular Biology, Division of Genetics and Development, University of California, Berkeley, Berkeley, CA 94720, USA
    Mol Cell 13:19-32. 2004
    ..factors have been implicated in this process: the REL-containing proteins, Dorsal, Dif, and Relish, and the GATA factor Serpent. Here we present evidence that REL-GATA synergy plays a pervasive role in the immune response...
  26. pmc Cellular immune response to parasitization in Drosophila requires the EBF orthologue collier
    Michele Crozatier
    Centre de Biologie du Developpement, Centre National de la Recherche Scientifique and Université Paul Sabatier, Toulouse, France
    PLoS Biol 2:E196. 2004
    ..Further investigations on Col/EBF expression and function in other phyla should provide fresh insight into the evolutionary origin of lymphoid cells...
  27. pmc Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration
    Brian Stramer
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK
    J Cell Biol 168:567-73. 2005
    ..Cdc42 is necessary for maintaining cellular polarity and yet, despite in vitro evidence, is dispensable for sensing and crawling toward wound cues...
  28. ncbi The Drosophila lymph gland as a developmental model of hematopoiesis
    Seung Hye Jung
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Development 132:2521-33. 2005
    ..The cellular events identified in this analysis further establish Drosophila as a model system for hematopoiesis...
  29. ncbi D-six4 plays a key role in patterning cell identities deriving from the Drosophila mesoderm
    Ivan B N Clark
    Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
    Dev Biol 294:220-31. 2006
    ..At stage 9, however, D-six4 and tin are both expressed pan-mesodermally. At this stage, tin function is required for full D-six4 expression. This may explain the known requirement for tin in some non-dorsal cell types...
  30. pmc Distinct mechanisms regulate hemocyte chemotaxis during development and wound healing in Drosophila melanogaster
    Will Wood
    Instituto Gulbenkian de Ciencia, 2780 156 Oeiras, Portugal
    J Cell Biol 173:405-16. 2006
    ....
  31. ncbi Regulation of Drosophila friend of GATA gene, u-shaped, during hematopoiesis: a direct role for serpent and lozenge
    Selen Muratoglu
    Center for Vascular and Inflammatory Diseases and the Department of Pathology, University of Maryland School of Medicine, 800 W Baltimore Street, Baltimore, MD 21201, USA
    Dev Biol 296:561-79. 2006
    Friend of GATA proteins interact with GATA factors to regulate development in a variety of tissues...
  32. ncbi Zfrp8, the Drosophila ortholog of PDCD2, functions in lymph gland development and controls cell proliferation
    Svetlana Minakhina
    Waksman Institute, Department of Molecular Biology and Biochemistry, Cancer Institute of New Jersey, Rutgers University, 190 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Development 134:2387-96. 2007
    ..The overproliferation of cells in the lymph gland results in abnormal hemocyte differentiation...
  33. pmc The GATA factor Serpent cross-regulates lozenge and u-shaped expression during Drosophila blood cell development
    Selen Muratoglu
    Center for Vascular and Inflammatory Diseases, Department of Pathology, University of Maryland, School of Medicine, 800 W Baltimore Street, Room 215, Baltimore, MD 21201, USA
    Dev Biol 311:636-49. 2007
    The Drosophila GATA factor Serpent interacts with the RUNX factor Lozenge to activate the crystal cell program, whereas SerpentNC binds the Friend of GATA protein U-shaped to limit crystal cell production...
  34. ncbi The Friend of GATA protein U-shaped functions as a hematopoietic tumor suppressor in Drosophila
    Richard Paul Sorrentino
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Dev Biol 311:311-23. 2007
    ..Here we show that the Friend of GATA (FOG) protein U-shaped (Ush) is expressed in circulating and lymph gland hemocytes, where it plays a critical role ..
  35. ncbi Gene expression analysis in post-embryonic pericardial cells of Drosophila
    Debjani Das
    Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur PO, Bangalore 560064, India
    Gene Expr Patterns 8:199-205. 2008
    ..Tin is not expressed in any post-embryonic PC. Additionally larval PCs also express the GATA factor, Serpent (Srp) and the extracellular matrix protein, Pericardin (Prc)...
  36. pmc Salmonella pathogenesis reveals that BMP signaling regulates blood cell homeostasis and immune responses in Drosophila
    Joel L Frandsen
    School of Life Sciences, Arizona State University, Tempe, AZ 85287 4501, USA
    Proc Natl Acad Sci U S A 105:14952-7. 2008
    ..The cascade begins with Dpp repression of Zfh1, continues with Zfh1 activation of Serpent (Srp; a GATA factor), and terminates with Srp activation of U-shaped (Ush) in hematopoietic cells...
  37. pmc An innate immune response of blood cells to tumors and tissue damage in Drosophila
    Jose Carlos Pastor-Pareja
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06519, USA
    Dis Model Mech 1:144-54; discussion 153. 2008
    ..Our findings reveal common mechanisms in the response to tumors and wounds in flies. A similar innate reaction may underlie the response to tumors and tissue damage in vertebrates and humans...
  38. doi Fusion of circular and longitudinal muscles in Drosophila is independent of the endoderm but further visceral muscle differentiation requires a close contact between mesoderm and endoderm
    Georg Wolfstetter
    Institut für Allgemeine und Spezielle Zoologie, Allgemeine Zoologie und Entwicklungsbiologie, Justus Liebig Universitat Giessen, Stephanstrasse 24, D 35390 Giessen, Germany
    Mech Dev 126:721-36. 2009
    ....
  39. pmc Elimination of plasmatocytes by targeted apoptosis reveals their role in multiple aspects of the Drosophila immune response
    Bernard Charroux
    Institut de Biologie du Developpement de Marseille Luminy, Unite Mixte de Recherche 6216, Centre National de la Recherche Scientifique, Université de la Méditerrannée Aix Marseille II, 13288 Marseille Cedex 9, France
    Proc Natl Acad Sci U S A 106:9797-802. 2009
    ..Finally, we show that plasmatocytes are involved in immune surveillance during pupal development, because they prevent bacterial infection that causes pupal lethality...
  40. pmc Drosophila laminins act as key regulators of basement membrane assembly and morphogenesis
    Jose M Urbano
    Centro Andaluz de Biología de Desarrollo CABD, Univ Pablo de Olavide CSIC, 41013 Sevilla, Spain
    Development 136:4165-76. 2009
    ..We propose that while an early function of laminins in gastrulation is not conserved in Drosophila and mammals, their function in basement membrane assembly and organogenesis seems to be maintained throughout evolution...
  41. pmc Serpent, suppressor of hairless and U-shaped are crucial regulators of hedgehog niche expression and prohemocyte maintenance during Drosophila larval hematopoiesis
    Yumiko Tokusumi
    Department of Biological Sciences, University of Notre Dame, 147 Galvin Life Sciences Hall, Notre Dame, IN 46556, USA
    Development 137:3561-8. 2010
    ..The GATA factor Serpent (Srp) is essential for hh activation in niche cells, whereas the Suppressor of Hairless [Su(H)] and ..
  42. doi Specific GATA factors act as conserved inducers of an endodermal-EMT
    Kyra Campbell
    Institut de Biologia Molecular de Barcelona CSIC, Parc Cientific de Barcelona, 08028 Barcelona, Spain
    Dev Cell 21:1051-61. 2011
    ..Here, we demonstrate that EMT in the Drosophila endoderm is dependent on the GATA-factor Serpent (Srp), and that Srp acts as a potent trigger for this transition when activated ectopically...
  43. pmc Drosophila E-cadherin functions in hematopoietic progenitors to maintain multipotency and block differentiation
    Hongjuan Gao
    Center for Vascular and Inflammatory Diseases and the Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 8:e74684. 2013
    ..Furthermore, our studies indicate that the Drosophila GATA transcriptional co-factor, U-shaped, is required for E-cadherin expression...
  44. ncbi zfh-1 is required for germ cell migration and gonadal mesoderm development in Drosophila
    H T Broihier
    Skirball Institute, New York University Medical Center, NY, NY 10016, USA
    Development 125:655-66. 1998
    ..Finally, through analysis of a tinman zfh-1 double mutant, we show that zfh-1 acts in conjunction with tinman, another homeodomain protein, in the specification of lateral mesodermal derivatives, including the gonadal mesoderm...
  45. ncbi Macrophage-mediated corpse engulfment is required for normal Drosophila CNS morphogenesis
    Heather C Sears
    Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue 68 230B, Cambridge, MA 02139, USA
    Development 130:3557-65. 2003
    ..These data indicate that macrophage-mediated clearance of cell corpses is required for proper morphogenesis of the Drosophila CNS...
  46. ncbi Evidence for a fruit fly hemangioblast and similarities between lymph-gland hematopoiesis in fruit fly and mammal aorta-gonadal-mesonephros mesoderm
    Lolitika Mandal
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
    Nat Genet 36:1019-23. 2004
    ..In addition, the GATA factor gene pannier (pnr) and the homeobox gene tinman (tin), which are controlled by the convergence of ..
  47. ncbi The gene serpent has homeotic properties and specifies endoderm versus ectoderm within the Drosophila gut
    R Reuter
    Max Planck Institut fur Entwicklungsbiologie, Abteilung V, Tubingen, FR Germany
    Development 120:1123-35. 1994
    ..The fate shifts in both the anterior and the posterior part of the srp embryo can be described in terms of homeotic transformations of anterior midgut to foregut and of posterior midgut ..
  48. ncbi Blood cells of Drosophila: cell lineages and role in host defence
    Marie Meister
    Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, 67084 Strasbourg, France
    Curr Opin Immunol 16:10-5. 2004
    ..Crystal cells and lamellocytes have no clear mammalian homologues. Research into the molecular mechanisms that underlie the various immune functions of Drosophila blood cells, such as non-self recognition, is now taking wing...
  49. ncbi The evolutionary ecology of resistance to parasitoids by Drosophila
    M D Fellowes
    NERC Centre for Population Biology, Imperial College at Silwood Park, Ascot, Berkshire SL5 7PY, UK
    Heredity (Edinb) 84:1-8. 2000
    ..Finally, the possible population and community ecological consequences of evolution in the levels of host resistance are examined...
  50. pmc Patterning of the cardiac outflow region in Drosophila
    Martina Zikova
    Institut National de la Sante et de la Recherche Medicale, Unité 384, Faculte de Medecine, 28 Place Henri Dunant, 63001 Clermont Ferrand, France
    Proc Natl Acad Sci U S A 100:12189-94. 2003
    ....
  51. pmc Ecdysone triggered PGRP-LC expression controls Drosophila innate immunity
    Florentina Rus
    Department of Medicine, Division of Infectious Disease, University of Massachusetts Medical School, Worcester, MA, USA
    EMBO J 32:1626-38. 2013
    ..We identify a group of steroid-regulated transcription factors as well as two GATA transcription factors that act as repressors and activators of the immune response and are required for the proper ..
  52. doi cis-regulatory requirements for tissue-specific programs of the circadian clock
    Antonio C A Meireles-Filho
    Research Institute of Molecular Pathology IMP, 1030 Vienna, Austria
    Curr Biol 24:1-10. 2014
    ..Yet, how CLK and CYC determine tissue-specific clock programs has remained unclear...
  53. pmc Identification of methylmercury tolerance gene candidates in Drosophila
    Cecon T Mahapatra
    Department of Anatomy and Neurobiology, College of Medicine, University of Vermont, Burlington, Vermont 05405, USA
    Toxicol Sci 116:225-38. 2010
    ..Identification of TotA and CYP genes as MeHg tolerance genes is an inroad to investigating the conserved function of immune signaling and phase I metabolism pathways in MeHg toxicity and tolerance in higher organisms...
  54. pmc Lack of an antibacterial response defect in Drosophila Toll-9 mutant
    Karine Narbonne-Reveau
    Institut de Biologie du Developpement de Marseille Luminy, CNRS UMR 6216 Aix Marseille II University, Campus de Luminy, Marseille, France
    PLoS ONE 6:e17470. 2011
    ..Our results suggest that Toll-9 is neither required to maintain a basal anti-microbial response nor to mount an efficient immune response to bacterial infection...
  55. ncbi Cytogenetic analysis of chromosome region 89A of Drosophila melanogaster: isolation of deficiencies and mapping of Po, Aldox-1 and transposon insertions
    C R Nelson
    Department of Biological Chemistry, Milton S Hershey Medical Center, Pennsylvania State University, Hershey 17033
    Mol Gen Genet 235:11-21. 1992
    ..the indirect flight muscle genes Tm2 and act88F, the morphological mutations jvl, sbd2 and Sb, the vital loci srp, pnr and mor, and a newly described vital locus l(3)89Aa...
  56. pmc Expanding the Mot1 subfamily: 89B helicase encodes a new Drosophila melanogaster SNF2-related protein which binds to multiple sites on polytene chromosomes
    R Goldman-Levi
    Hubert H Humphrey Center for Experimental Medicine and Cancer Research, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Nucleic Acids Res 24:3121-8. 1996
    ....
  57. pmc A genetic analysis of pannier, a gene necessary for viability of dorsal tissues and bristle positioning in Drosophila
    P Heitzler
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    Genetics 143:1271-86. 1996
    ..A large number of alleles have been studied and reveal that pannier may have opposing effects on the expression of achaete and scute leading to a loss or a gain of bristles...
  58. ncbi Control of germ-band retraction in Drosophila by the zinc-finger protein HINDSIGHT
    M L Yip
    Division of Biology, California Institute of Technology, Pasadena, USA
    Development 124:2129-41. 1997
    ..Second, hindsight might function both to maintain the amnioserosa and to regulate chemical signaling from the amnioserosa to the epidermal ectoderm, thus coordinating the cell shape changes and movements that drive germ-band retraction...
  59. ncbi Regulation of the twist target gene tinman by modular cis-regulatory elements during early mesoderm development
    Z Yin
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Development 124:4971-82. 1997
    ....
  60. ncbi Differential regulation of gastrulation and neuroectodermal gene expression by Snail in the Drosophila embryo
    K Hemavathy
    Program in Molecular Medicine, Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01605, USA
    Development 124:3683-91. 1997
    ..Together with the data showing that the expression of some ventral genes disappear in snail mutants, we propose that Snail may repress or activate another set of target genes that are required specifically for gastrulation...
  61. ncbi Dual role for the zeste-white3/shaggy-encoded kinase in mesoderm and heart development of Drosophila
    M Park
    Department of Biology, University of Michigan, Ann Arbor 48109 1048, USA
    Dev Genet 22:201-11. 1998
    ....
  62. ncbi Dissection of chromosome region 89A of Drosophila melanogaster by local transposition of P elements
    H Matsubayashi
    Department of Applied Biology, Kyoto Institute of Technology, Japan
    Genes Genet Syst 73:95-103. 1998
    ..These analyses delimited the rec gene to within 21 kb of the cloned DNA, although the c3G gene could not be located on the molecular map...
  63. pmc The trithorax group gene moira encodes a brahma-associated putative chromatin-remodeling factor in Drosophila melanogaster
    M A Crosby
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Mol Cell Biol 19:1159-70. 1999
    ..These observations provide a molecular explanation for the phenotypic and genetic relationships among several of the trxG genes by suggesting that they encode evolutionarily conserved components of a chromatin-remodeling complex...
  64. pmc Dual requirement for the EcR/USP nuclear receptor and the dGATAb factor in an ecdysone response in Drosophila melanogaster
    V Brodu
    Institut Jacques Monod, Laboratoire de Biologie du Developpement, CNRS UMR 7592, Universite Paris 7 Denis Diderot, Université Paris 6 P et M Curie, 75251 Paris Cedex 05, France
    Mol Cell Biol 19:5732-42. 1999
    ..We show here that the dGATAb factor binds to three target sites flanking an EcR/USP binding site in a 70-bp enhancer that controls the tissue ..
  65. ncbi The zinc finger proteins Pannier and GATA4 function as cardiogenic factors in Drosophila
    K Gajewski
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Development 126:5679-88. 1999
    The regulation of cardiac gene expression by GATA zinc finger transcription factors is well documented in vertebrates...
  66. ncbi Endoderm development: from patterning to organogenesis
    A Grapin-Botton
    Department of Molecular and Cellular Biology, and Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Trends Genet 16:124-30. 2000
    ..Some of the classical embryology of the endoderm is discussed and the progress and deficiencies in cellular and molecular studies are noted...
  67. ncbi The alternative migratory pathways of the Drosophila tracheal cells are associated with distinct subsets of mesodermal cells
    X Franch-Marro
    Institut de Biologia Molecular de Barcelona, C Jordi Girona 18 26, Barcelona, 08034, Spain
    Dev Biol 227:80-90. 2000
    ..These results show how adjacent tissues influence morphogenesis of the tracheal system and offer a model for understanding how organ formation is determined by its genetic program and by the surrounding topological constraints...
  68. ncbi Identification of fat-cell enhancer regions in Drosophila melanogaster
    J M Miller
    Department of Biological Sciences, University of Nevada, Las Vegas, 4505 Maryland Parkway, Box 454004, Las Vegas, Nevada 89154 4004, USA
    Insect Mol Biol 11:67-77. 2002
    ..We have identified a 2.1 kb enhancer region from serpent (srp), a GATA transcription factor gene that is sufficient to induce fat-cell formation...
  69. ncbi Walking the walk: migration and other common themes in blood and vascular development
    David Traver
    Children s Hospital, Howard Hughes Medical Institute, Harvard University Medical School, Boston, MA 02115, USA
    Cell 108:731-4. 2002
    ..Their work suggests that an ancestral function of VEGF was to guide blood cell migration and highlights the conservation of at least one aspect of VEGF signaling during evolution...
  70. ncbi Insect hemocytes and their role in immunity
    M D Lavine
    Department of Entomology, University of Georgia, Athens, GA 30602, USA
    Insect Biochem Mol Biol 32:1295-309. 2002
    ..Cross-talk between the immune and nervous system may also play a role in regulating inflammation-like responses in insects during infection...
  71. ncbi The repressor function of snail is required for Drosophila gastrulation and is not replaceable by Escargot or Worniu
    Kirugaval Hemavathy
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Dev Biol 269:411-20. 2004
    ..Together, the results show that the repressor function of Snail is essential for gastrulation. The repression of target genes by Snail may permit other factors in the ventral cells to positively promote mesoderm invagination...
  72. ncbi Use of regression methods to identify motifs that modulate germline transcription in Drosophila melanogaster
    Emily Honeycutt
    Bioinformatics Research Center, North Carolina State University, Raleigh, NC 27695 7566, USA
    Genet Res 83:177-88. 2004
    ..We obtained a strong result for motif TCGATA, part of the larger, characterized binding site of dGATAb protein...
  73. ncbi An endoderm-specific GATA factor gene, dGATAe, is required for the terminal differentiation of the Drosophila endoderm
    Takashi Okumura
    Department of Physics, Biology, and Informatics, Yamaguchi University, Yamaguchi 753 8512, Japan
    Dev Biol 278:576-86. 2005
    b>GATA factors play an essential role in endodermal specification in both protostomes and deuterostomes. In Drosophila, the GATA factor gene serpent (srp) is critical for differentiation of the endoderm...
  74. ncbi Hand is a direct target of Tinman and GATA factors during Drosophila cardiogenesis and hematopoiesis
    Zhe Han
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Development 132:3525-36. 2005
    ..The homeodomain protein Tinman and the GATA factors Pannier and Serpent directly activate Hand in these cell types through a minimal enhancer, which is ..
  75. ncbi Resolving embryonic blood cell fate choice in Drosophila: interplay of GCM and RUNX factors
    Laetitia Bataillé
    Centre de Biologie du Developpement, CNRS UMR 5547, 118 route de Narbonne, 31062 Toulouse, France
    Development 132:4635-44. 2005
    ..These results provide new insight into the mechanisms controlling Drosophila hematopoiesis and establish the basis for an original model for the resolution of the choice of blood cell fate...
  76. pmc GATA factors participate in tissue-specific immune responses in Drosophila larvae
    Kate Senger
    Department of Molecular and Cell Biology, Division of Genetics, Genomics, and Development, Center for Integrative Genomics, University of California, Berkeley, CA 94720 3204, USA
    Proc Natl Acad Sci U S A 103:15957-62. 2006
    ..The regulation of antimicrobial genes in larval fat depends on linked Rel/NF-kappaB and GATA binding sites. Serpent functions as the major GATA transcription factor in the larval fat body...
  77. ncbi A GATA/RUNX cis-regulatory module couples Drosophila blood cell commitment and differentiation into crystal cells
    Geraldine Ferjoux
    Centre de Biologie du Developpement, UMR 5547, CNRS Université Paul Sabatier Toulouse III, 118 route de Narbonne, 31062 Toulouse, France
    Dev Biol 305:726-34. 2007
    Members of the RUNX and GATA transcription factor families play critical roles during hematopoiesis from Drosophila to mammals...
  78. pmc Gene induction following wounding of wild-type versus macrophage-deficient Drosophila embryos
    Brian Stramer
    Department of Physiology, School of Medical Sciences, University of Bristol, UK
    EMBO Rep 9:465-71. 2008
    ....
  79. pmc The evolution of protostome GATA factors: molecular phylogenetics, synteny, and intron/exon structure reveal orthologous relationships
    William Q Gillis
    Institute of Molecular Biology, University of Oregon, 1229 University of Oregon, Eugene, OR 97403, USA
    BMC Evol Biol 8:112. 2008
    Invertebrate and vertebrate GATA transcription factors play important roles in ectoderm and mesendoderm development, as well as in cardiovascular and blood cell fate specification...
  80. pmc Repression of RNA polymerase II transcription by a Drosophila oligopeptide
    Gyula Timinszky
    Gene Expression Unit, European Molecular Biology Laboratory, Heidelberg, Germany
    PLoS ONE 3:e2506. 2008
    ..This occurs through the transient repression in primordial germ cells of RNA polymerase II, specifically by disrupting Ser2 phosphorylation on its C-terminal domain...
  81. pmc Motif-blind, genome-wide discovery of cis-regulatory modules in Drosophila and mouse
    Miriam R Kantorovitz
    Department of Mathematics, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Dev Cell 17:568-79. 2009
    ..Overall, 7/7 predictions were validated successfully in vivo, demonstrating the effectiveness of our approach for insect and mammalian genomes...
  82. pmc The establishment of sexual identity in the Drosophila germline
    Abbie L Casper
    Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA
    Development 136:3821-30. 2009
    ..This is consistent with our findings that signals from the soma are dominant over germline autonomous cues at the initial stage of germline sex determination...
  83. pmc Toll-dependent antimicrobial responses in Drosophila larval fat body require Spätzle secreted by haemocytes
    Alice K H Shia
    Department of Biochemistry, University of Oxford, Oxford, UK
    J Cell Sci 122:4505-15. 2009
    ..These results show that in larvae, integration of the two responses in a systemic reaction depend on the production of a cytokine (spz), a process that strongly parallels the mammalian immune response...
  84. pmc A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in Drosophila
    Vanessa Gobert
    Université de Toulouse UPS, CBD Centre de Biologie du Développement, Bâtiment 4R3, 118 route de Narbonne, 31062 Toulouse, France
    Mol Cell Biol 30:2837-48. 2010
    Transcription factors of the RUNX and GATA families play key roles in the control of cell fate choice and differentiation, notably in the hematopoietic system...
  85. pmc RhoL controls invasion and Rap1 localization during immune cell transmigration in Drosophila
    Daria Siekhaus
    HHMI and Kimmel Center for Biology and Medicine of the Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York, New York 10016 6481, USA
    Nat Cell Biol 12:605-10. 2010
    ..Our work establishes the utility of Drosophila for identifying novel components of immune cell transmigration and for understanding the in vivo interplay of immune cells with the barriers they penetrate...
  86. pmc Regulation of Drosophila yolk protein genes by an ovary-specific GATA factor
    M Lossky
    Rosenstiel Center, Brandeis University, Waltham, Massachusetts 02254 9110, USA
    Mol Cell Biol 15:6943-52. 1995
    ..We show that among the Drosophila genes known to encode GATA factors, only dGATAb is expressed in ovaries...
  87. ncbi Control of gut development by fork head and cell signaling molecules in Drosophila
    M Hoch
    Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Gottingen, Germany
    Mech Dev 58:3-14. 1996
    ..These results provide strong evidence that similar principles underlie Drosophila fore- and hindgut development, and that the genetic hierarchy of gut development might be conserved between Drosophila and vertebrates...
  88. ncbi Cellular pathways acting along the germband and in the amnioserosa may participate in germband retraction of the Drosophila melanogaster embryo
    R Goldman-Levi
    Hubert H Humphrey Center for Experimental Medicine and Cancer Research, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Int J Dev Biol 40:1043-51. 1996
    ..While the role of the amnioserosa during germband retraction appears to be permissive, the action of DER in the germband may be mediated by the cytoskeleton...
  89. ncbi Segmentation and specification of the Drosophila mesoderm
    N Azpiazu
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Genes Dev 10:3183-94. 1996
    ..mesodermal genes: bagpipe (bap), which defines the anlagen of the visceral musculature of the midgut, and serpent (srp), which marks the anlagen of the fat body...
  90. ncbi Mammalian and Drosophila blood: JAK of all trades?
    B Mathey-Prevot
    Pediatric Oncology, The Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 92:697-700. 1998
  91. ncbi Germ plasm assembly and germ cell migration in Drosophila
    C Rongo
    Skirball Institute, New York University Medical Center, New York 10016, USA
    Cold Spring Harb Symp Quant Biol 62:1-11. 1997
    ..Further genetic studies will reveal the extent to which molecular aspects of germ cell migration and gonad formation are conserved...
  92. ncbi Organogenesis: Drosophila goes gonadal
    K Howard
    MRC Laboratory for Molecular Cell Biology, University College London, UK
    Curr Biol 8:R415-7. 1998
    ..Recent work in Drosophila has built a picture of the gene activities that specify the gonad and allow it to attract germ cells, and has led to the identification of a gene, columbus, that may encode the attractive factor...
  93. pmc Coordinating cell fate and morphogenesis in Drosophila renal tubules
    C Ainsworth
    Department of Human Anatomy and Genetics, University of Oxford, UK
    Philos Trans R Soc Lond B Biol Sci 355:931-7. 2000
    ..We show that the regulator of Rac, Myoblast city is essential for this second morphogenetic process...
  94. ncbi A glimpse into the molecular entrails of endoderm formation
    Didier Y R Stainier
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, University of California, San Francisco, San Francisco, California 94143 0448, USA
    Genes Dev 16:893-907. 2002
  95. pmc piggyBac-based insertional mutagenesis in the presence of stably integrated P elements in Drosophila
    Udo Hacker
    Department of Cell and Molecular Biology, BMC B13, Lund University, 22184 Lund, Sweden
    Proc Natl Acad Sci U S A 100:7720-5. 2003
    ..Our data demonstrate the potential of this technique to facilitate the quest for saturation mutagenesis of the Drosophila genome. The system is Drosophila nonspecific and potentially applicable in a broad spectrum of nonmodel organisms...
  96. ncbi Establishing A-P polarity in the embryonic heart tube: a conserved function of Hox genes in Drosophila and vertebrates?
    Patrick C H Lo
    Brookdale Center for Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    Trends Cardiovasc Med 13:182-7. 2003
    ..These results suggest that the Hox genes may also play some role in the positioning of the embryonic heart field and the determination of A-P polarity in the vertebrate embryonic heart tube...
  97. ncbi Organ positioning in Drosophila requires complex tissue-tissue interactions
    Melissa S Vining
    The Johns Hopkins University School of Medicine, Department of Cell Biology, Baltimore, MD 21205, USA
    Dev Biol 287:19-34. 2005
    ..These data further the understanding of how organ morphology and position are determined by three-dimensional constraints and guidance cues provided by neighboring tissues...
  98. ncbi Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila
    Christine Kocks
    Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cell 123:335-46. 2005
    ..Our results suggest that Eater is a major phagocytic receptor for a broad range of bacterial pathogens in Drosophila and provide a powerful model to address the role of phagocytosis in vivo...
  99. ncbi GATAe-dependent and -independent expressions of genes in the differentiated endodermal midgut of Drosophila
    Takashi Okumura
    Department of Biology and Chemistry, Yamaguchi University, Yoshida 1677 1, Yamaguchi 753 8512, Japan
    Gene Expr Patterns 7:178-86. 2007
    Two sequentially-expressed GATA factor genes, serpent (srp) and GATAe, are essential for development of the Drosophila endoderm...
  100. ncbi Serpent and a hibris reporter are co-expressed in migrating cells during Drosophila hematopoiesis and Malpighian tubule formation
    Ruben D Artero
    Laboratory of Developmental Genetics, Dept of Genetics, University of Valencia, Dr Moliner 50, ES 46100 Burjasot, Spain
    Hereditas 143:117-22. 2006
    ..blood cell precursors or prohemocytes, are first detected in the procephalic mesoderm by the expression of the GATA transcription factor Serpent...
  101. ncbi Identification of a crystal cell-specific enhancer of the black cells prophenoloxidase gene in Drosophila
    Kathleen M Gajewski
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genesis 45:200-7. 2007
    ..Expression of this fragment is altered by mutations in the GATA family serpent (srp) and RUNX family lozenge (lz) genes; Srp and Lz are required for crystal cell specification...