Genomes and Genes
Gene Symbol: spin
Alias: 25/11, CG8428, Dmel\CG8428, Spin, bnch, l(2)10403, l(2)W5, l(2)k02511, l(2)k09905, l(2R)W5, CG8428 gene product from transcript CG8428-RB, CG8428-PA, CG8428-PB, CG8428-PC, CG8428-PD, CG8428-PE, Spinster/Benchwarmer, benchwarmer, diphthong, lethal (2) W5, spin-PA, spin-PB, spin-PC, spin-PD, spin-PE
Species: fruit fly
- The mating of a flyJ C Hall
Department of Biology, Brandeis University, Waltham, MA 02254 9110
Science 264:1702-14. 1994..Further behavioral mutations seemed originally to be courtship-specific, turned out not to have that property, and have led to a broadened perspective on the nature and action of Drosophila's sex-determination genes...
- Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvationYueguang Rong
State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Science, Tsinghua University, Beijing 100084, China
Proc Natl Acad Sci U S A 108:7826-31. 2011..Spinster (Spin) encodes a putative lysosomal efflux permease with the hallmarks of a sugar transporter...
- A dual function of V0-ATPase a1 provides an endolysosomal degradation mechanism in Drosophila melanogaster photoreceptorsW Ryan Williamson
Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
J Cell Biol 189:885-99. 2010..We propose that V100 exerts a temporally integrated dual function that increases neuronal degradative capacity...
- The coiled-coil protein shrub controls neuronal morphogenesis in DrosophilaNeal T Sweeney
Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, California 94158, USA
Curr Biol 16:1006-11. 2006..Our findings demonstrate that the novel coiled-coil protein Shrub functions in the endosomal pathway and plays an essential role in neuronal morphogenesis...
- Zebrafish yolk-specific not really started (nrs) gene is a vertebrate homolog of the Drosophila spinster gene and is essential for embryogenesisRodrigo M Young
Millennium Nucleus in Developmental Biology and Departamento de Biologia, Facultad de Ciencias, Universidad de Chile Santiago, Chile
Dev Dyn 223:298-305. 2002..These results suggest that the nrs mutation affects an essential gene encoding a putative membrane-bound protein expressed specifically in the yolk cell during zebrafish embryogenesis...
- Internalization is required for proper Wingless signaling in Drosophila melanogasterElaine S Seto
Department of Molecular and Human Genetics, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
J Cell Biol 173:95-106. 2006..As these data indicate that endosomal transport promotes Wg signaling, our findings suggest that the regulation of endocytosis is a novel mechanism through which Wg signaling levels are determined...
- Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmerBart Dermaut
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
J Cell Biol 170:127-39. 2005..Here, we report that loss of Drosophila benchwarmer (bnch), a predicted lysosomal sugar carrier, leads to carbohydrate storage in yolk spheres during oogenesis and ..
- Drosophila spichthyin inhibits BMP signaling and regulates synaptic growth and axonal microtubulesXinnan Wang
Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK
Nat Neurosci 10:177-85. 2007....
- Lis1, the Drosophila homolog of a human lissencephaly disease gene, is required for germline cell division and oocyte differentiationZ Liu
The Waksman Institute, Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854 8020, USA
Development 126:4477-88. 1999..They support the notion that LIS1 functions with the dynein complex to regulate nuclear migration or cell migration...
- Mutations in the novel membrane protein spinster interfere with programmed cell death and cause neural degeneration in Drosophila melanogasterY Nakano
ERATO Yamamoto Behavior Genes Project, Japan Science and Technology Corporation at Mitsubishi Kasei Institute of Life Sciences, Machida, Tokyo 194 8511, Japan
Mol Cell Biol 21:3775-88. 2001Mutations in the spin gene are characterized by an extraordinarily strong rejection behavior of female flies in response to male courtship...
- Unrestricted synaptic growth in spinster-a late endosomal protein implicated in TGF-beta-mediated synaptic growth regulationSean T Sweeney
Department of Biochemistry, 513 Parnassus Avenue, HSE 901, University of California, San Francisco, San Francisco, CA 94143, USA
Neuron 36:403-16. 2002In a genetic screen for genes that control synapse development, we have identified spinster (spin), which encodes a multipass transmembrane protein...
- Spinsters, synaptic defects, and amaurotic idiocySubhabrata Sanyal
Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA
Neuron 36:335-8. 2002..This study provides important new information at an intersection of several disciplines, including membrane traffic, lipid organization, synaptic signaling, and neurodegenerative lysosomal storage disease...
- Select interneuron clusters determine female sexual receptivity in DrosophilaAkira Sakurai
Division of Neurogenetics, Tohoku University Graduate School of Life Sciences, Sendai 980 8577, Japan
Nat Commun 4:1825. 2013..we show that the non-copulating phenotype can be recapitulated by the elimination of spinster functions from either spin-A or spin-D neuronal clusters, in the otherwise wild-type (spinster heterozygous) female brain...
- Drosophila Rab14 mediates phagocytosis in the immune response to Staphylococcus aureusAprajita Garg
Institute for Bioscience and Biotechnology Research, Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, 20742, USA
Cell Microbiol 16:296-310. 2014..aureus phagosomes. The defect in phagocytosis is associated with higher bacterial load and increased susceptibility to S. aureus in the animal. ..
- Spartin regulates synaptic growth and neuronal survival by inhibiting BMP-mediated microtubule stabilizationMinyeop Nahm
Department of Cell and Developmental Biology, Dental Research Institute, Seoul National University, Seoul 110 749, Republic of Korea
Neuron 77:680-95. 2013....
- Dmon1 controls recruitment of Rab7 to maturing endosomes in DrosophilaJahan Yousefian
Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstrasse 1, 40225 Dusseldorf, Germany
J Cell Sci 126:1583-94. 2013..This was the case even when receptor uptake into intraluminal vesicles was suppressed...
- Genome-wide quantitative enhancer activity maps identified by STARR-seqCosmas D Arnold
Research Institute of Molecular Pathology IMP, Vienna, Austria
Science 339:1074-7. 2013..STARR-seq can be used to identify and quantify enhancer activity in other eukaryotes, including humans...
- Mutation of a NCKX eliminates glial microdomain calcium oscillations and enhances seizure susceptibilityJan E Melom
Picower Institute for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Neurosci 33:1169-78. 2013..These studies demonstrate that microdomain glial Ca(2+) oscillations require NCKX-mediated plasma membrane Ca(2+) flux, and that acute dysregulation of glial Ca(2+) signaling triggers seizures...
- Fine-scale genetic analysis of species-specific female preference in Drosophila simulansM Laturney
Department of Biology, The University of Western Ontario, London, ON, Canada
J Evol Biol 25:1718-31. 2012....
- Genetic elevation of sphingosine 1-phosphate suppresses dystrophic muscle phenotypes in DrosophilaMario Pantoja
Department of Biochemistry, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA
Development 140:136-46. 2013..Our data suggest that localized intracellular S1P elevation promotes the suppression of muscle wasting in flies...
- Commissureless regulation of axon outgrowth across the midline is independent of Rab functionDaan M van den Brink
Medical Research Council Centre for Developmental Neurobiology, King s College London, London, United Kingdom
PLoS ONE 8:e64427. 2013..In addition we reveal that axon outgrowth of many populations of neurons within the Drosophila central nervous system is also independent of Rab activity...
- Epsin 1 Promotes Synaptic Growth by Enhancing BMP Signal Levels in Motoneuron NucleiPhillip A Vanlandingham
Department of Biology, University of Oklahoma, Norman, Oklahoma
PLoS ONE 8:e65997. 2013..fails to accumulate inside the motoneuron nuclei in lqf mutants and lqf suppresses synaptic overgrowth in spinster (spin) mutants with enhanced BMP signaling by reducing accumulation of nuclear pMad...
- Charcot-Marie-Tooth 2B mutations in rab7 cause dosage-dependent neurodegeneration due to partial loss of functionSmita Cherry
Department of Physiology, University of Texas Southwestern Medical Center, Dallas, United States
elife 2:e01064. 2013..Our results suggest a therapeutic approach opposite to the currently proposed reduction of mutant protein function. DOI: http://dx.doi.org/10.7554/eLife.01064.001. ..
- dAcsl, the Drosophila ortholog of acyl-CoA synthetase long-chain family member 3 and 4, inhibits synapse growth by attenuating bone morphogenetic protein signaling via endocytic recyclingZhihua Liu
Key Laboratory for Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China, and Institute of Life Science and the Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China
J Neurosci 34:2785-96. 2014..Together, our results reveal a novel mechanism whereby dAcsl facilitates Rab11-dependent receptor recycling and provide insights into the pathogenesis of ACSL4-related mental retardation. ..
- Genome-wide association analysis of tolerance to methylmercury toxicity in Drosophila implicates myogenic and neuromuscular developmental pathwaysSara L Montgomery
Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America
PLoS ONE 9:e110375. 2014..Furthermore, our observations that caffeine can ameliorate the toxic effects of MeHg show that nutritional factors and dietary manipulations may offer protection against the deleterious effects of MeHg exposure. ..
- Rab8, POSH, and TAK1 regulate synaptic growth in a Drosophila model of frontotemporal dementiaRyan J H West
Department of Biology and Hull York Medical School, University of York, Heslington, York YO10 5DD, England, UK Department of Biology and Hull York Medical School, University of York, Heslington, York YO10 5DD, England, UK
J Cell Biol 208:931-47. 2015..Our data uncover Rab8, POSH, and TAK1 as regulators of synaptic growth responses and point to recycling endosome as a key compartment for synaptic growth regulation during neurodegenerative processes. ..
- VCP-dependent muscle degeneration is linked to defects in a dynamic tubular lysosomal network in vivoAlyssa E Johnson
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, United States
elife 4:. 2015..We propose that VCP sustains sarcoplasmic proteostasis, in part, by controlling the integrity of a dynamic tubular lysosomal network. ..
- Diminished MTORC1-Dependent JNK Activation Underlies the Neurodevelopmental Defects Associated with Lysosomal DysfunctionChing On Wong
Department of Integrative Biology and Pharmacology, University of Texas School of Medicine, Houston, TX 77030, USA
Cell Rep 12:2009-20. 2015..Our findings provide an explanation for the neurodevelopmental deficits in LSDs and suggest an actionable target for treatment. ..
- Electron Transport Chain Remodeling by GSK3 during Oogenesis Connects Nutrient State to ReproductionMatthew H Sieber
Department of Embryology, Carnegie Institution of Washington, 3520 San Martin Drive, Baltimore, MD 21218, USA
Cell 164:420-32. 2016..Our studies reveal an important link between metabolism and oocyte maturation. ..
- Multivariate profiling of neurodegeneration-associated changes in a subcellular compartment of neurons via image processingSaravana K Kumarasamy
Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, 04 01, 138669, Singapore
BioData Min 1:10. 2008..However, the subtle morphological changes in compartments of affected neurons are difficult to quantify quickly and reliably, making this phenotype inaccessible as either an early diagnostic marker, or as a read-out for drug screening...
- The novel endosomal membrane protein Ema interacts with the class C Vps-HOPS complex to promote endosomal maturationSungsu Kim
Department of Developmental Biology, Washington University in St Louis, St Louis, MO 63110, USA
J Cell Biol 188:717-34. 2010..Characterizing this novel gene family identifies a new component of the endosomal pathway and provides insights into class C Vps-HOPS complex function...
- The nuclear protein Waharan is required for endosomal-lysosomal trafficking in DrosophilaMohiddin Lone
Faculty of Life Sciences, The University of Manchester, Oxford Road, M13 9PT Manchester, UK
J Cell Sci 123:2369-74. 2010..This finding suggests the existence of a relationship between nuclear functions and endolysosomal trafficking. Future studies of Wah function will give us insights into this interesting phenomenon...
- Oxidative stress induces overgrowth of the Drosophila neuromuscular junctionValerie J Milton
Department of Biology and Hull York Medical School, University of York, York YO10 5DD, United Kingdom
Proc Natl Acad Sci U S A 108:17521-6. 2011..In previous work, we identified a Drosophila model of lysosomal storage disease (LSD), spinster (spin), with larval neuromuscular synapse overgrowth...
- The tumour suppressor Lethal (2) giant discs is required for the function of the ESCRT-III component Shrub/CHMP4Tobias Troost
Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitätsstrasse1, 40225, Dusseldorf, Germany
J Cell Sci 125:763-76. 2012....
- Phenotypic interactions of spinster with the genes encoding proteins for cell death control in Drosophila melanogasterAkira Sakurai
Division of Neurogenetics, Tohoku University Graduate School of Life Sciences, Sendai, Miyagi, Japan
Arch Insect Biochem Physiol 73:119-27. 2010The spin gene was first identified by its mutant phenotype, which is characterized by extremely strong mate refusal by females in response to male courtship in Drosophila...
- Spinster controls Dpp signaling during glial migration in the Drosophila eyeYeliz Yuva-Aydemir
Institut fur Neurobiologie, Universitat Munster, D 48149 Munster, Germany
J Neurosci 31:7005-15. 2011..In addition, Spinster affects the growth of the carpet cell, which indirectly modulates glial migration...
- Cell-autonomous requirement for DNaseII in nonapoptotic cell deathB P Bass
Department of Biology, Boston University, Boston, MA 02215, USA
Cell Death Differ 16:1362-71. 2009..Furthermore, we provide evidence that developmental nurse cell PCD in late oogenesis shows hallmarks of necrosis. These findings indicate that DNaseII can act cell autonomously to degrade DNA during nonapoptotic cell death...
- The Drosophila BEACH family protein, blue cheese, links lysosomal axon transport with motor neuron degenerationAngeline Lim
Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, California 95064, USA
J Neurosci 29:951-63. 2009..We suggest therefore that anterograde transport of lysosomes toward synaptic termini is a key factor in preventing motor neuron degeneration and that Bchs reveals a functional link between the lysosomal degradative pathway and transport...
- Dynein is required for polarized dendritic transport and uniform microtubule orientation in axonsYi Zheng
Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
Nat Cell Biol 10:1172-80. 2008..These data suggest that dynein is required for the distinguishing properties of the axon and dendrites: without dynein, dendritic organelles and proteins enter the axon and the axonal microtubules are no longer uniform in polarity...
- The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in DrosophilaGabor Juhasz
Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
J Cell Biol 181:655-66. 2008..Our results suggest that Vps34 is regulated by TOR-dependent nutrient signals directly at sites of autophagosome formation...
- Neuromuscular control of a single twitch muscle in wild type and mutant Drosophila, measured with an ergometerJennifer Harvey
Department of Biology, University of York, PO Box 373, York, UK
Invert Neurosci 8:63-70. 2008..However, responses in highwire mutations gradually decline following repeated stimuli, suggesting physiological as well as anatomical abnormalities. We conclude that the assay is robust, sensitive and reliable with a good throughput...
- Genetic and chemical modifiers of a CUG toxicity model in DrosophilaAmparo Garcia-Lopez
Department of Genetics, University of Valencia, Burjasot, Spain
PLoS ONE 3:e1595. 2008..These findings provide new insights into the DM1 phenotype, and suggest novel candidates for DM1 treatments...
- Orchestrating development and function: retrograde BMP signaling in the Drosophila nervous systemHaig Keshishian
Department of Molecular, Cellular and Developmental Biology, Yale University, PO Box 208103, New Haven, CT 06520 8103, USA
Trends Neurosci 27:143-7. 2004..Together, the results suggest that retrograde growth factor signaling by BMPs integrates neuromuscular development and function at both local and global levels in the animal...
- Pathology of the adult central nervous system induced by genetic inhibition of programmed cell death in Drosophila pupaeKazue Usui-Aoki
ERATO Yamamoto Behavior Genes Project, JST, University of Hawaii at Marõa, Honolulu, Hawaii, USA
Arch Insect Biochem Physiol 49:94-101. 2002In the spinster (spin) mutant of Drosophila melanogaster, the extent of programmed cell death (PCD) in the abdominal ganglion 6 h after puparium formation (APF) is significantly reduced...
- Sexual behavior mutants revisited: molecular and cellular basis of Drosophila matingD Yamamoto
ERATO Yamamoto Behavior Genes Project, Mitsubishi Kasei Institute of Life Sciences, Machida, Tokyo, Japan
Cell Mol Life Sci 56:634-46. 1999..The issue as to how the mutations that reduce female sexual receptiveness, e.g. dissatisfaction (dsf), spinster (spin) and chaste (cht), affect the structure and/or function of this neural center deserves to be addressed urgently.
- The Drosophila shark tyrosine kinase is required for embryonic dorsal closureR Fernandez
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, The Bronx, New York 10461, USA
Genes Dev 14:604-14. 2000..Furthermore, constitutive activation of the Dpp pathway throughout the epidermis fails to rescue the shark(1) DC defect, suggesting that Shark may function in additional pathways in the LE and/or lateral epithelium...
- From behavior to development: genes for sexual behavior define the neuronal sexual switch in DrosophilaD Yamamoto
ERATO Yamamoto Behavior Genes Project, JST, Mitsubishi Kasei Institute of Life Sciences, Machida, Tokyo 194 8511, Japan
Mech Dev 73:135-46. 1998....
- Genes for sexual behaviorD Yamamoto
ERATO Yamamoto Behavior Genes Project, JST, Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
Biochem Biophys Res Commun 246:1-6. 1998..This strategy of artificial control of fly behavior opens up an avenue for studies to identify the neural center for individual behavioral actions...
- Drosophila immunity: analysis of larval hemocytes by P-element-mediated enhancer trapA Braun
Unité Propre de Recherche 9022 du CNRS, Institut de Biologie Moleculaire et Cellulaire, Strasbourg, France
Genetics 147:623-34. 1997..We anticipate that this mutation, which we named domino, will prove a useful tool in the analysis of the role of hemocytes during the various aspects of immune response and melanotic tumor formation...
- Novel Molecular Tools for Transsynaptic Circuit AnalysisHaig Keshishian; Fiscal Year: 2007..unreadable] [unreadable]..