sna

Summary

Gene Symbol: sna
Description: snail
Alias: BG:DS01845.1, CG3956, Dmel\CG3956, SNA, SNAIL, Sco, Sna, br28, br29, l(2)35Db, l(2)br28, l(2)br29, l(3)br28, l35Db, CG3956 gene product from transcript CG3956-RA, CG3956-PA, scutoid, sna-PA
Species: fruit fly

Top Publications

  1. ncbi The snail gene required for mesoderm formation in Drosophila is expressed dynamically in derivatives of all three germ layers
    A Alberga
    Laboratoire de Génétique Moléculaire des Eucaryotes du Centre National de la Recherche Scientifique, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medicine, Strasbourg, France
    Development 111:983-92. 1991
  2. pmc zfh-1, the Drosophila homologue of ZEB, is a transcriptional repressor that regulates somatic myogenesis
    A A Postigo
    Division of Molecular Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 19:7255-63. 1999
  3. ncbi Localized repressors delineate the neurogenic ectoderm in the early Drosophila embryo
    Angelike Stathopoulos
    Division of Genetics and Development, Department of Molecular Cell Biology, Center for Integrative Genomics, University of California, Berkeley, 94720, USA
    Dev Biol 280:482-93. 2005
  4. pmc Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growth
    Nicholas S Sokol
    Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Genes Dev 19:2343-54. 2005
  5. ncbi Computational models for neurogenic gene expression in the Drosophila embryo
    Robert P Zinzen
    Center for Integrative Genomics, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720 3204, USA
    Curr Biol 16:1358-65. 2006
  6. pmc Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed
    G Jimenez
    Imperial Cancer Research Fund ICRF, London WC2A 3PX, England
    Genes Dev 11:3072-82. 1997
  7. pmc Quantitative analysis of binding motifs mediating diverse spatial readouts of the Dorsal gradient in the Drosophila embryo
    Dmitri Papatsenko
    Department of Molecular and Cell Biology, Division of Genetics, Genomics, and Development, Center for Integrative Genomics, University of California, 16 Barker Hall No 3204, Berkeley, CA 94720 3204, USA
    Proc Natl Acad Sci U S A 102:4966-71. 2005
  8. ncbi Molecular recognition of transcriptional repressor motifs by the WD domain of the Groucho/TLE corepressor
    Barbara H Jennings
    Developmental Genetics Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Mol Cell 22:645-55. 2006
  9. pmc Evolution acts on enhancer organization to fine-tune gradient threshold readouts
    Justin Crocker
    Department of Biological Sciences, Dartmouth College, Hanover, NH, USA
    PLoS Biol 6:e263. 2008
  10. doi Drosophila alpha-1,4-glycosyltransferase (alpha-4GT1) inhibits reaper-mediated apoptosis in the eye
    C E Protzer
    Universitat Hohenheim, Institut für Genetik 240, Garbenstrasse 30, 70599, Stuttgart, Germany
    Cell Tissue Res 336:149-58. 2009

Research Grants

  1. CONFOCAL MICROSCOPE FOR LIVE CELL & MULTIWAVELENGTH WORK
    Mark Peifer; Fiscal Year: 2001
  2. Evolution of insect gastrulation
    Matthew Ronshaugen; Fiscal Year: 2006
  3. Apoptosis Signaling: BH3 to BH123 Proteins
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2008
  4. SPECIFICITY OF FIBROBLAST GROWTH FACTOR SIGNALING IN DROSOPHILA
    ANGELIKE M STATHOPOULOS; Fiscal Year: 2010
  5. L1-MEDIATED RECRUITMENT OF THE MEMBRANE SKELETON
    Michael Hortsch; Fiscal Year: 2002
  6. High-Volume Confocal Imaging System
    Stephen Crews; Fiscal Year: 2005
  7. BH3-only protein BNIP3 in tumor progression
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2006
  8. SUMO conjugation in cell biology and Development
    Albert J Courey; Fiscal Year: 2010
  9. Molecular Genetics of Midline Glial Development
    Stephen T Crews; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications127 found, 100 shown here

  1. ncbi The snail gene required for mesoderm formation in Drosophila is expressed dynamically in derivatives of all three germ layers
    A Alberga
    Laboratoire de Génétique Moléculaire des Eucaryotes du Centre National de la Recherche Scientifique, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medicine, Strasbourg, France
    Development 111:983-92. 1991
    The zygotic effect gene snail (sna) encodes a zinc-finger protein required for mesoderm formation in Drosophila embryos...
  2. pmc zfh-1, the Drosophila homologue of ZEB, is a transcriptional repressor that regulates somatic myogenesis
    A A Postigo
    Division of Molecular Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 19:7255-63. 1999
    ....
  3. ncbi Localized repressors delineate the neurogenic ectoderm in the early Drosophila embryo
    Angelike Stathopoulos
    Division of Genetics and Development, Department of Molecular Cell Biology, Center for Integrative Genomics, University of California, Berkeley, 94720, USA
    Dev Biol 280:482-93. 2005
    ..Spatially localized repressors such as Snail and Vnd exclude the expression of neurogenic genes in the mesoderm and ventral neuroectoderm, respectively...
  4. pmc Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growth
    Nicholas S Sokol
    Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Genes Dev 19:2343-54. 2005
    ..Thus, DmiR-1 is not required for the formation or physiological function of the larval musculature, but is required for the dramatic post-mitotic growth of larval muscle...
  5. ncbi Computational models for neurogenic gene expression in the Drosophila embryo
    Robert P Zinzen
    Center for Integrative Genomics, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720 3204, USA
    Curr Biol 16:1358-65. 2006
    ..Quantitative models based on the fractional occupancy of Dorsal, Twist, and Snail binding sites raise the possibility that cooperative interactions among these regulatory proteins mediate subtle ..
  6. pmc Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed
    G Jimenez
    Imperial Cancer Research Fund ICRF, London WC2A 3PX, England
    Genes Dev 11:3072-82. 1997
    ..In contrast, repressor regions from the Even-skipped, Snail, Krüppel, and Knirps transcription factors are effective in the absence of Gro...
  7. pmc Quantitative analysis of binding motifs mediating diverse spatial readouts of the Dorsal gradient in the Drosophila embryo
    Dmitri Papatsenko
    Department of Molecular and Cell Biology, Division of Genetics, Genomics, and Development, Center for Integrative Genomics, University of California, 16 Barker Hall No 3204, Berkeley, CA 94720 3204, USA
    Proc Natl Acad Sci U S A 102:4966-71. 2005
    ..Similar motif arrangements were identified in orthologous loci in the distant mosquito genome, Anopheles gambiae. We discuss how Dorsal and Twist work either additively or synergistically to activate different target enhancers...
  8. ncbi Molecular recognition of transcriptional repressor motifs by the WD domain of the Groucho/TLE corepressor
    Barbara H Jennings
    Developmental Genetics Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Mol Cell 22:645-55. 2006
    ..Our structural and functional analysis explains the rigid conservation of the WRPW motif, the sequence flexibility of eh1 motifs, and other aspects of repressor recognition by Gro in vivo...
  9. pmc Evolution acts on enhancer organization to fine-tune gradient threshold readouts
    Justin Crocker
    Department of Biological Sciences, Dartmouth College, Hanover, NH, USA
    PLoS Biol 6:e263. 2008
    ..Our study demonstrates that equivalence classes of CRMs are powerful tools for detecting lineage-specific adaptations by gene regulatory sequences...
  10. doi Drosophila alpha-1,4-glycosyltransferase (alpha-4GT1) inhibits reaper-mediated apoptosis in the eye
    C E Protzer
    Universitat Hohenheim, Institut für Genetik 240, Garbenstrasse 30, 70599, Stuttgart, Germany
    Cell Tissue Res 336:149-58. 2009
    ..alpha-4GT1 does not enhance Hairless-mediated cell death; instead, Hairless enhancement is caused by an allele of Scutoid present on the alpha-4GT1 chromosome...
  11. ncbi Ventral dominance governs sequential patterns of gene expression across the dorsal-ventral axis of the neuroectoderm in the Drosophila embryo
    John Cowden
    Department of Molecular and Cell Biology, Division of Genetics and Development, 401 Barker Hall, University of California, Berkeley, CA 94720, USA
    Dev Biol 262:335-49. 2003
    ....
  12. ncbi The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo
    Y T Ip
    Biology Department, University of California, San Diego, La Jolla 92093 0322
    Genes Dev 6:1728-39. 1992
    ..Expression is blocked in ventral regions (the presumptive mesoderm) by snail (sna), which is also a direct target of the dl morphogen...
  13. ncbi dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo
    Y T Ip
    Biology Department, University of California, San Diego, La Jolla 92093 0322
    Genes Dev 6:1518-30. 1992
    ..step in the differentiation of the Drosophila mesoderm is the activation of two regulatory genes, twist (twi) and snail (sna), in ventral regions of early embryos...
  14. ncbi The control of cell fate along the dorsal-ventral axis of the Drosophila embryo
    R P Ray
    Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138
    Development 113:35-54. 1991
    ..expression patterns of four zygotic patterning genes: decapentaplegic (dpp), zerknüllt (zen), twist (twi), and snail (sna)...
  15. ncbi twist and snail as positive and negative regulators during Drosophila mesoderm development
    M Leptin
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Genes Dev 5:1568-76. 1991
    twist and snail are members of the helix-loop-helix and zinc-finger protein families, respectively, and determine the development of the mesoderm in Drosophila...
  16. ncbi Establishment of the mesoderm-neuroectoderm boundary in the Drosophila embryo
    D Kosman
    Biology Department, University of California, San Diego, La Jolla 92093
    Science 254:118-22. 1991
    ..of gene expression along the dorsal-ventral axis of early embryos and activates the regulatory genes twist and snail, which are responsible for the differentiation of the ventral mesoderm...
  17. ncbi Cell shape changes during gastrulation in Drosophila
    M Leptin
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, West Germany
    Development 110:73-84. 1990
    ..Two known zygotic genes that are required for the formation of the mesoderm, twist and snail, are expressed in ventral furrow cells, and the correct execution of cell shape changes in the mesoderm depends on ..
  18. ncbi The Drosophila developmental gene snail encodes a protein with nucleic acid binding fingers
    J L Boulay
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Faculte de Medecine, Strasbourg, France
    Nature 330:395-8. 1987
    ..We have cloned snail (sna), a zygotic gene, whose expression is essential for the correct specification of dorsal-ventral pattern...
  19. ncbi Dorsal-ventral patterning genes restrict NK-2 homeobox gene expression to the ventral half of the central nervous system of Drosophila embryos
    D M Mellerick
    Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Dev Biol 171:306-16. 1995
    ..The NK-2 gene is not expressed in the mesodermal anlage due to repression by snail, in mesectodermal cells due to repression by single-minded, or in the lateral neuroectodermal and/or dorsal ..
  20. pmc Multiple modes of dorsal-bHLH transcriptional synergy in the Drosophila embryo
    P Szymanski
    Department of Biology, University of California at San Diego, La Jolla 92093 0347, USA
    EMBO J 14:2229-38. 1995
    ..We propose that this linkage requirement provides the basis for the evolution of modular promoters composed of discrete, non-overlapping enhancers...
  21. ncbi Short-range repression permits multiple enhancers to function autonomously within a complex promoter
    S Gray
    Department of Biology, University of California at San Diego, La Jolla 92093 0322
    Genes Dev 8:1829-38. 1994
    ..This study centers on a zinc finger repressor, snail (sna), which represses the expression of neuroectodermal regulatory genes in the presumptive mesoderm...
  22. ncbi Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene
    V Francois
    Department of Biology, University of California San Diego, La Jolla 92093
    Genes Dev 8:2602-16. 1994
    ..These putative soluble Sog peptides may then diffuse into the dorsal region to antagonize the activity of Dpp, leading to the subdivision of the dorsal territory into amnioserosa and dorsal ectoderm...
  23. ncbi Interacting functions of snail, twist and huckebein during the early development of germ layers in Drosophila
    R Reuter
    Max Planck Institut fur Entwicklungsbiologie, Abteilung V, Tubingen, FR Germany
    Development 120:1137-50. 1994
    Two zygotic genes, snail (sna) and twist (twi), are required for mesoderm development, which begins with the formation of the ventral furrow...
  24. pmc D-mef2: a Drosophila mesoderm-specific MADS box-containing gene with a biphasic expression profile during embryogenesis
    H T Nguyen
    Department of Cardiology, Children s Hospital, Boston, MA 02115
    Proc Natl Acad Sci U S A 91:7520-4. 1994
    ..twi activity is required for D-mef2 expression, while sna function may be needed for the maintenance of D-mef2 expression but not its initiation...
  25. ncbi A putative cell signal encoded by the folded gastrulation gene coordinates cell shape changes during Drosophila gastrulation
    M Costa
    Department of Molecular Biology, Princeton University, New Jersey 08544
    Cell 76:1075-89. 1994
    ..Our analyses indicate that cell-cell communication ensures the rapid, orderly progression of constriction initiations from the middle of invagination primordia out toward the margins...
  26. pmc D-MEF2: a MADS box transcription factor expressed in differentiating mesoderm and muscle cell lineages during Drosophila embryogenesis
    B Lilly
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Proc Natl Acad Sci U S A 91:5662-6. 1994
    ..Expression of D-mef2 is dependent on the mesodermal determinants twist and snail but independent of the homeobox-containing gene tinman, which is required for visceral muscle and heart ..
  27. pmc Definition of the DNA-binding site repertoire for the Drosophila transcription factor SNAIL
    V Mauhin
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medecine, Strasbourg, France
    Nucleic Acids Res 21:3951-7. 1993
    The Drosophila gene snail (sna) which encodes a zinc finger protein is essential for dorsal-ventral pattern formation in the developing embryo...
  28. ncbi Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen
    J Jiang
    Department of Biology, University of California, San Diego, La Jolla 92093 0322
    Cell 72:741-52. 1993
    ..The snail repressor blocks this interaction and restricts expression to the neuroectoderm...
  29. pmc The gap protein knirps mediates both quenching and direct repression in the Drosophila embryo
    D N Arnosti
    Department of Biology, UCSD, La Jolla 92093 0347, USA
    EMBO J 15:3659-66. 1996
    ..Our studies suggest that short-range repression represents a flexible form of gene regulation, exhibiting enhancer- or promoter-specific effects depending on the location of repressor binding sites...
  30. ncbi Regulation and function of the terminal gap gene huckebein in the Drosophila blastoderm
    G Bronner
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Int J Dev Biol 40:157-65. 1996
    ..Conversely, ectopic expression of hkb inhibits the formation of the major gastrulation fold which gives rise to the mesoderm and prevents normal segmentation in the ectoderm of the trunk region...
  31. ncbi Orthodenticle regulation during embryonic head development in Drosophila
    Q Gao
    University of Pennsylvania School of Medicine, Department of Neuroscience, Philadelphia, PA 19104, USA
    Mech Dev 56:3-15. 1996
    ..Finally, we identify a novel pathway mediated by the gap gene huckebein through which three maternal systems cooperate to repress otd expression at the anterior terminus of the embryo...
  32. ncbi The role of the msh homeobox gene during Drosophila neurogenesis: implication for the dorsoventral specification of the neuroectoderm
    T Isshiki
    National Institute for Basic Biology, Okazaki, Japan
    Development 124:3099-109. 1997
    ....
  33. pmc Conversion of dorsal from an activator to a repressor by the global corepressor Groucho
    T Dubnicoff
    Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 11:2952-7. 1997
    ..Groucho is therefore a critical component of the dorsal/ventral patterning system...
  34. ncbi Regulation of zygotic gene expression in Drosophila primordial germ cells
    M Van Doren
    Skirball Institute, NYU Medical Center, New York 10016, USA
    Curr Biol 8:243-6. 1998
    ..This expression does not require proper patterning of the soma, indicating that it is likely to be controlled by the germ plasm...
  35. pmc dCtBP mediates transcriptional repression by Knirps, Krüppel and Snail in the Drosophila embryo
    Y Nibu
    Department of Molecular and Cellular Biology, Division of Genetics, 401 Barker Hall, University of California, Berkeley, CA 94720, USA
    EMBO J 17:7009-20. 1998
    ..Here we present evidence that three different repressors, Knirps, Krüppel and Snail, recruit a different co-repressor, dCtBP...
  36. pmc Gastrulation in Drosophila: the logic and the cellular mechanisms
    M Leptin
    Institut fur Genetik, Universitat zu Koln, Weyertal 121, D 50931 Köln, Germany
    EMBO J 18:3187-92. 1999
    ....
  37. ncbi A genetic link between morphogenesis and cell division during formation of the ventral furrow in Drosophila
    J Grosshans
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, New Jersey 08540, USA
    Cell 101:523-31. 2000
    ..Effective inhibition of mitosis in the cells of the ventral furrow depends on the transcription factor Snail that triggers the ventral cell shape changes...
  38. ncbi Transcriptional repression: the long and the short of it
    A J Courey
    Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 15:2786-96. 2001
  39. ncbi The Snail protein family regulates neuroblast expression of inscuteable and string, genes involved in asymmetry and cell division in Drosophila
    S I Ashraf
    Program in Molecular Medicine and Department of Cell Biology, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Development 128:4757-67. 2001
    ..b>Snail, a zinc-finger transcriptional repressor, is a pan-neural protein, based on its extensive expression in ..
  40. pmc Genome-wide analysis of clustered Dorsal binding sites identifies putative target genes in the Drosophila embryo
    Michele Markstein
    Department of Molecular and Cell Biology, Division of Genetics and Development, 401 Barker Hall, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 99:763-8. 2002
    ..These results suggest that bioinformatics can be used to identify novel target genes and associated regulatory DNAs in a gene network...
  41. ncbi A Twist in fate: evolutionary comparison of Twist structure and function
    Irinka Castanon
    Program in Molecular Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Gene 287:11-22. 2002
    ..Conserved principles and the molecular mechanisms underlying them are discussed...
  42. pmc The Dorsal Rel homology domain plays an active role in transcriptional regulation
    Songtao Jia
    Department of Chemistry and Biochemistry, University of California Los Angeles, 405 Hilgard Street, Los Angeles, CA 90095 1569, USA
    Mol Cell Biol 22:5089-99. 2002
    ..These results provide some of the first evidence that the RHD plays an active role in transcriptional regulation in intact multicellular organisms...
  43. ncbi Linear signaling in the Toll-Dorsal pathway of Drosophila: activated Pelle kinase specifies all threshold outputs of gene expression while the bHLH protein Twist specifies a subset
    Angelike Stathopoulos
    Department of Molecular and Cell Biology, Division of Genetics and Development, 401 Barker Hall, University of California, Berkeley, CA 94720, USA
    Development 129:3411-9. 2002
    ..We discuss how the Dorsal gradient system can be modified during metazoan evolution and conclude that Dorsal-Twist interactions are distinct from the interplay between Bicoid and Hunchback, which pattern the anteroposterior axis...
  44. ncbi Mechanical induction of Twist in the Drosophila foregut/stomodeal primordium
    Emmanuel Farge
    Mechanics and Genetics of Developmental Embryogenesis Group, Unité Mixte de Recherche 168 Physico Chimie Curie, Curie Institute, 11 rue Pierre et Marie Curie, 75005 Paris, France
    Curr Biol 13:1365-77. 2003
    ..At embryogenesis gastrulation (stage 7), Twist is also expressed in the anterior foregut and stomodeal primordia...
  45. pmc Spatial regulation of microRNA gene expression in the Drosophila embryo
    Frederic Biemar
    Division of Genetics and Development, Department of Molecular Cell Biology, Center for Integrative Genomics, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 102:15907-11. 2005
    ..These results provide evidence that restricted activities of the 8-miR and miR-1 miRNAs are mediated by classical tissue-specific enhancers...
  46. ncbi Dorsal-ventral pattern of Delta trafficking is established by a Snail-Tom-Neuralized pathway
    Stefano de Renzis
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Dev Cell 10:257-64. 2006
    ..We have addressed the snail-dependent regulation of Delta trafficking during the plasma membrane growth of the mesoderm in the Drosophila ..
  47. ncbi The TAGteam DNA motif controls the timing of Drosophila pre-blastoderm transcription
    John R ten Bosch
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3204, USA
    Development 133:1967-77. 2006
    ....
  48. ncbi Conservation patterns in different functional sequence categories of divergent Drosophila species
    Dmitri Papatsenko
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA
    Genomics 88:431-42. 2006
    ..We discuss how restraining conservation patterns may help in mapping functional sequence categories and improve genome annotation...
  49. pmc Comprehensive identification of Drosophila dorsal-ventral patterning genes using a whole-genome tiling array
    Frederic Biemar
    Division of Genetics and Development, Department of Molecular Cell Biology, Center for Integrative Genomics, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 103:12763-8. 2006
    ..We discuss the potential functions of these recently identified genes and suggest that intronic enhancers are a common feature of the DV gene network...
  50. ncbi Uncoupling dorsal-mediated activation from dorsal-mediated repression in the Drosophila embryo
    Girish S Ratnaparkhi
    Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095 1569, USA
    Development 133:4409-14. 2006
    ..factor Dorsal patterns the dorsoventral axis of the Drosophila embryo by activating genes such as twist and snail and repressing genes such as decapentaplegic and zerknüllt...
  51. ncbi Control of Drosophila gastrulation by apical localization of adherens junctions and RhoGEF2
    Verena Kölsch
    Institute of Genetics, University of Cologne, Zulpicher Strasse 47, 50674 Cologne, Germany
    Science 315:384-6. 2007
    ..Together with G protein signaling, T48 recruits adherens junctions and the cytoskeletal regulator RhoGEF2 to the sites of apical constriction, ensuring rapid and intense changes in cell shape...
  52. ncbi Analysis and reconstitution of the genetic cascade controlling early mesoderm morphogenesis in the Drosophila embryo
    Thomas C Seher
    Institute of Genetics, University of Cologne, Weyertal 121, D 50931 Cologne, Germany
    Mech Dev 124:167-79. 2007
    ..activator Twist, which acts at the top of the mesodermal developmental cascade in Drosophila, two targets, Snail and Fog, are known to be necessary for the first morphogenetic event, the orderly invagination of the mesoderm...
  53. pmc Enhancer responses to similarly distributed antagonistic gradients in development
    Robert P Zinzen
    Department of Molecular and Cell Biology, Center for Integrative Genomics, University of California, Berkeley, California, United States of America
    PLoS Comput Biol 3:e84. 2007
    ....
  54. pmc Functional conservation of Rel binding sites in drosophilid genomes
    Richard R Copley
    Wellcome Trust Centre for Human Genetics, Oxford University, Oxford OX3 7BN, United Kingdom
    Genome Res 17:1327-35. 2007
    ..We discuss how two types of conservation may contribute to the stabilization and optimization of a functional gene regulatory code in evolution...
  55. pmc RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo
    Julia Zeitlinger
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Genet 39:1512-6. 2007
    ..We propose that Pol II stalling facilitates rapid temporal and spatial changes in gene activity during development...
  56. pmc Differential in vivo requirements for oligomerization during Groucho-mediated repression
    Barbara H Jennings
    Developmental Genetics Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London, UK
    EMBO Rep 9:76-83. 2008
    ..Our results show that homo-oligomerization of Gro is not obligatory for its action in vivo, and that Gro represses transcription through more than one molecular mechanism...
  57. pmc Transcription factors bind thousands of active and inactive regions in the Drosophila blastoderm
    Xiao Yong Li
    Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS Biol 6:e27. 2008
    ....
  58. pmc Dorsal interacting protein 3 potentiates activation by Drosophila Rel homology domain proteins
    Girish S Ratnaparkhi
    Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA, USA
    Dev Comp Immunol 32:1290-300. 2008
    ..Chromatin immunoprecipitation experiments in S2 cells indicate the presence of Dip3 at the promoters of these genes, and this binding requires the presence of Rel proteins at these promoters...
  59. doi Mechanical signals trigger Myosin II redistribution and mesoderm invagination in Drosophila embryos
    Philippe Alexandre Pouille
    UMR 168, CNRS, Institut Curie, 11 rue Pierre et Marie Curie, 75005 Paris, France
    Sci Signal 2:ra16. 2009
    ..by the constriction of 40% of randomly positioned mesodermal cells and is controlled by the transcription factor Snail. The second constriction wave immediately follows and involves the other 60% of the mesodermal cells...
  60. doi The Ca2+-dependent protease Calpain A regulates Cactus/I kappaB levels during Drosophila development in response to maternal Dpp signals
    M Fontenele
    Institute for Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro 21941 902, Brazil
    Mech Dev 126:737-51. 2009
    ..This mechanism may allow coordination of Toll, BMP and Ca(2+) signals, conferring precision to Dorsal-target expression domains...
  61. pmc Developmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regions
    Stewart MacArthur
    Genomics Division, Lawrence Berkeley National Laboratory, Cyclotron Road MS 84 181, Berkeley, CA 94720, USA
    Genome Biol 10:R80. 2009
    ....
  62. pmc Myosin II dynamics are regulated by tension in intercalating cells
    Rodrigo Fernandez-Gonzalez
    Howard Hughes Medical Institute, Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065 USA
    Dev Cell 17:736-43. 2009
    ..These results demonstrate that myosin II dynamics are regulated by tension in a positive feedback loop that leads to multicellular actomyosin cable formation and efficient tissue elongation...
  63. pmc Quantitative imaging of the Dorsal nuclear gradient reveals limitations to threshold-dependent patterning in Drosophila
    Louisa M Liberman
    Division of Biology, California Institute of Technology, 1200 East California Boulevard, MC114 96, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 106:22317-22. 2009
    ....
  64. pmc Deciphering a transcriptional regulatory code: modeling short-range repression in the Drosophila embryo
    Walid D Fakhouri
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824 1319, USA
    Mol Syst Biol 6:341. 2010
    ..of these proteins' activity that allow accurate predictions of regulation by the Giant, Knirps, Krüppel, and Snail repressors, including modeling of an endogenous enhancer...
  65. pmc Integration of contractile forces during tissue invagination
    Adam C Martin
    Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA
    J Cell Biol 188:735-49. 2010
    ..Thus, pulsed actomyosin contractions require a supracellular, tensile meshwork to transmit cellular forces to the tissue level during morphogenesis...
  66. pmc Oscillatory behaviors and hierarchical assembly of contractile structures in intercalating cells
    Rodrigo Fernandez-Gonzalez
    Howard Hughes Medical Institute, Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA
    Phys Biol 8:045005. 2011
    ..We discuss models to explain how the architecture of cytoskeletal networks regulates their contractile behavior and the mechanisms that give rise to oscillatory cell behaviors in intercalating cells...
  67. pmc Role for Traf4 in polarizing adherens junctions as a prerequisite for efficient cell shape changes
    Sam J Mathew
    Institute of Genetics, University of Cologne, Zulpicher Strasse 47, 50674 Cologne, Germany
    Mol Cell Biol 31:4978-93. 2011
    ..Traf4 acts in a TNF receptor- and Jun N-terminal protein kinase (JNK)-independent manner to fine-tune the assembly of adherens junctions in the invaginating mesodermal cells...
  68. pmc Dorsal-ventral gene expression in the Drosophila embryo reflects the dynamics and precision of the dorsal nuclear gradient
    Gregory T Reeves
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Dev Cell 22:544-57. 2012
    ..We propose that mRNA levels remain plastic during transient signaling events, allowing tissues to refine patterns in the face of genetic or environmental variation...
  69. ncbi Mesodermal repression of single-minded in Drosophila embryo is mediated by a cluster of Snail-binding sites proximal to the early promoter
    Kye Won Park
    Department of Food Science and Biotechnology, Sungkyunkwan University, Suwon, Korea
    BMB Rep 45:577-82. 2012
    ..Recent identification of the mesectoderm enhancer (MSE) of sim has led to the hypothesis that two Snail (Sna)-binding sites in the MSE may repress sim expression in the presumptive mesoderm...
  70. pmc Variation in the dorsal gradient distribution is a source for modified scaling of germ layers in Drosophila
    Juan Sebastian Chahda
    Department of Biology, Case Western Reserve University, Cleveland, OH 44106, USA
    Curr Biol 23:710-6. 2013
    ..We propose that variation in mesodermal size occurs at a fast evolutionary rate and is an important mechanism to define the ventral boundary of the neuroectoderm...
  71. pmc Size-dependent regulation of dorsal-ventral patterning in the early Drosophila embryo
    Mayra García
    Division of Biology, California Institute of Technology, Pasadena, CA, USA
    Dev Biol 381:286-99. 2013
    ..In particular, the patterns of snail (sna) and ventral nervous system defective (vnd) correlate with nuclear Dorsal levels and exhibit scaling to DV ..
  72. pmc Mutations in eukaryotic release factors 1 and 3 act as general nonsense suppressors in Drosophila
    Anna T Chao
    Department of Biology, Duke University, Durham, North Carolina 27708 1000, USA
    Genetics 165:601-12. 2003
    ..Our findings have important implications for assigning null mutant phenotypes and for selecting appropriate alleles to use in suppressor screens...
  73. pmc Organization of developmental enhancers in the Drosophila embryo
    Dmitri Papatsenko
    Department of Molecular Cell Biology, Division of Genetics, Genomics and Development, Center for Integrative Genomics, University of California, Berkeley, CA 94720 200, USA
    Nucleic Acids Res 37:5665-77. 2009
    ..We conclude that grammar of gene control regions is pervasively used in the patterning of the Drosophila embryo...
  74. ncbi The embryonic expression patterns of zfh-1 and zfh-2, two Drosophila genes encoding novel zinc-finger homeodomain proteins
    Z C Lai
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Mech Dev 34:123-34. 1991
    ..The mesodermal zfh-1 expression requires the products of the twist and snail genes. The zfh-2 gene displays a more limited expression pattern, largely restricted to the CNS of late embryos...
  75. pmc HLH54F is required for the specification and migration of longitudinal gut muscle founders from the caudal mesoderm of Drosophila
    Afshan Ismat
    Mount Sinai School of Medicine, Department of Molecular, Cell and Developmental Biology currently Developmental and Regenerative Biology, Box 1020, Mount Sinai School of Medicine, New York, NY 10029, USA
    Development 137:3107-17. 2010
    ..We show that HLH54F expression in the CVM is regulated by a combination of terminal patterning genes and snail. We generated HLH54F mutations and show that this gene is crucial for the specification, migration and survival of ..
  76. ncbi Dorsoventral development of the Drosophila embryo is controlled by a cascade of transcriptional regulators
    C Thisse
    LGME du CNRS, U184 de l INSERM, Institut de Chimie Biologique, Faculte de Medecine, Strasbourg, France
    Dev Suppl . 1992
    ..In addition, in cultured cells twist has been shown to be a transcriptional activator. Thus, the first events of embryonic development along the D/V axis are controlled at the transcriptional level...
  77. ncbi The Drosophila gene escargot encodes a zinc finger motif found in snail-related genes
    M Whiteley
    Laboratory of Cellular and Molecular Biology, Food and Drug Administration, Bethesda, MD 20892
    Mech Dev 36:117-27. 1992
    ..of a cDNA clone from the region reveals that this gene has a high degree of similarity with the Drosophila snail gene (Boulay et al., 1987)...
  78. ncbi Generating lineage-specific markers to study Drosophila development
    N Perrimon
    Department of Genetics, Harvard Medical School, Boston, MA 02115
    Dev Genet 12:238-52. 1991
    ..Insertion strains generated with P-elements that carry various sequences upstream of the lacZ gene exhibit an increased variety of expression patterns that can be used to study Drosophila development...
  79. ncbi Interaction between torso and dorsal, two elements of different transduction pathways in the Drosophila embryo
    J Casanova
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Spain
    Mech Dev 36:41-5. 1991
    ..analyze the effect of the terminal system on the expression of two zygotic genes involved in dorsoventral pattern, snail and decapentaplegic, and I show that this effect is mediated by a reduction on dorsal activity by the terminal ..
  80. ncbi Beta 3 tubulin expression characterizes the differentiating mesodermal germ layer during Drosophila embryogenesis
    D Leiss
    Gentechnologische Arbeitsgruppe, Max Planck Institut fur Biochemie, Martinsried, FRG
    Development 104:525-31. 1988
    ..In dorsalizing mutants dorsal, snail and twist, which do not form a ventral furrow during gastrulation, beta 3 expression is greatly reduced but not ..
  81. ncbi Genes that control dorsoventral polarity affect gene expression along the anteroposterior axis of the Drosophila embryo
    S B Carroll
    Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder 80309 0347
    Development 99:327-32. 1987
    ....
  82. ncbi Drosophila development pulls the strings of the cell cycle
    B H Reed
    Whitehead Institute for Biomedical Research, Cambridge, MA, USA
    Bioessays 17:553-6. 1995
    ....
  83. ncbi The role of the cell cycle and cytokinesis in regulating neuroblast sublineage gene expression in the Drosophila CNS
    X Cui
    Howard Hughes Medical Institute, Department of Cell and Structural Biology, University of Illinois, Urbana 61801, USA
    Development 121:3233-43. 1995
    ..These results suggest that neuroblasts have an intrinsic gene regulatory hierarchy controlling unplugged and achaete expression, but that cell cycle- or cytokinesis-dependent mechanisms are required for ming and eve CNS expression...
  84. ncbi Regulation of muscle differentiation by the MEF2 family of MADS box transcription factors
    E N Olson
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Dev Biol 172:2-14. 1995
  85. ncbi Neurogenic and proneural genes control cell fate specification in the Drosophila endoderm
    U Tepass
    Department of Biology, University of California at Los Angeles 90024 1606, USA
    Development 121:393-405. 1995
    ..Our data also suggest that the neurogenic/proneural genes are involved in the choice between epithelial versus mesenchymal cell morphologies...
  86. pmc A novel basic helix-loop-helix protein is expressed in muscle attachment sites of the Drosophila epidermis
    P Armand
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014
    Mol Cell Biol 14:4145-54. 1994
    ..delilah expression persists in snail mutant embryos which lack mesoderm, indicating that expression of the gene was not induced by attachment of the ..
  87. ncbi Molecular and genetic characterization of the Drosophila tartan gene
    Z Chang
    Laboratory of Genetics, University of Wisconsin, Madison 53706
    Dev Biol 160:315-32. 1993
    ..Mutants are also defective in muscle organization. These results suggest that tartan is required for cell surface interactions important for normal organization of epidermal and subepidermal structures...
  88. ncbi Trans- and cis-acting requirements for blastodermal expression of the head gap gene buttonhead
    E A Wimmer
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Mech Dev 53:235-45. 1995
    ..Finally, the terminal system takes part in the regulation of btd head stripe expression by enhancing activation at low levels of activity and repression at high levels of activity...
  89. ncbi Specificity of CNS and PNS regulatory subelements comprising pan-neural enhancers of the deadpan and scratch genes is achieved by repression
    J F Emery
    Department of Biology, University of California, San Diego, La Jolla 92093, USA
    Development 121:3549-60. 1995
    ..We discuss the implications of the striking organizational similarities of the dpn, scrt, and sna pan-neural enhancers.
  90. ncbi Determination of wing cell fate by the escargot and snail genes in Drosophila
    N Fuse
    Genetic Stock Research Center, National Institute of Genetics, Shizuoka ken, Japan
    Development 122:1059-67. 1996
    ..We here report that two related transcription factors, Escargot and Snail that are expressed in the embryonic wing disc, function as intrinsic determinants of the wing cell fate...
  91. pmc Identification of immune system and response genes, and novel mutations causing melanotic tumor formation in Drosophila melanogaster
    A Rodriguez
    Department of Biology, University of Houston, Texas 77204, USA
    Genetics 143:929-40. 1996
    ..All are associated with reporter gene expression in at least one immune system tissue. Thor has increased expression upon infection. Mutations of wizard and dappled have a melanotic tumor phenotype...
  92. ncbi A myogenic switch. Muscle development
    M V Taylor
    Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, UK
    Curr Biol 6:924-6. 1996
    ..Experiments manipulating the level of the basic helix-loop-helix transcription factor Twist in the Drosophila embryo have revealed a novel role for this protein in a 'myogenic switch' during early development...
  93. pmc Identification of novel genes in Drosophila reveals the complex regulation of early gene activity in the mesoderm
    J Casal
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Proc Natl Acad Sci U S A 93:10327-32. 1996
    Two zygotic genes, twist and snail, are indispensable for the correct establishment of the mesoderm primordium in the early Drosophila embryo. They are also needed for morphogenesis and differentiation of the mesoderm...
  94. ncbi The Drosophila embryonic midline is the site of Spitz processing, and induces activation of the EGF receptor in the ventral ectoderm
    M Golembo
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Development 122:3363-70. 1996
    ..The production of secreted Spitz in the midline, may provide a stable source for graded DER activation in the ventral ectoderm...
  95. ncbi The Drosophila dCREB-A gene is required for dorsal/ventral patterning of the larval cuticle
    D J Andrew
    Department of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    Development 124:181-93. 1997
    ..The lateralizing phenotype of dCREB-A mutants reveals a much broader function for CREB proteins than previously thought...
  96. ncbi Anti-neural-inhibition: a conserved mechanism for neural induction
    E Bier
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla 92093 0349, USA
    Cell 89:681-4. 1997
  97. ncbi Control of cell lineage-specific development and transcription by bHLH-PAS proteins
    S T Crews
    Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7260 USA
    Genes Dev 12:607-20. 1998
  98. ncbi The function of hairy-related bHLH repressor proteins in cell fate decisions
    A Fisher
    Department of Cell Biology and Anatomy, Cornell University Medical College, New York, New York, USA
    Bioessays 20:298-306. 1998
    ..This general function in cell fate specification has been conserved from Drosophila to vertebrates and has implications for human disease pathogenesis...
  99. ncbi Dynamic behavior of the cadherin-based cell-cell adhesion system during Drosophila gastrulation
    H Oda
    Exploratory Research for Advanced Technology, Japan Science and Technology Corporation, Kyoto Research Park, Kyoto, Chudoji Minami machi, Shimogyo ku, 600 8813, Japan
    Dev Biol 203:435-50. 1998
    ..DE- to the DN-type in the mesodermal germ layer occurred downstream of the mesoderm-determination genes twist and snail. However, examination of their protein expression patterns showed that considerable amounts of DE-cadherin ..
  100. ncbi Development of larval body wall muscles
    M Bate
    Department of Zoology, University of Cambridge, United Kingdom
    Int Rev Neurobiol 43:25-44. 1999
  101. ncbi Huckebein repressor activity in Drosophila terminal patterning is mediated by Groucho
    R E Goldstein
    Department of Biochemistry, Hadassah Medical School, The Hebrew University, PO Box 12272, Jerusalem 91120, Israel
    Development 126:3747-55. 1999
    ..Taken together with our earlier results, these findings show that Groucho-repression regulates sequential aspects of terminal patterning in Drosophila...

Research Grants9

  1. CONFOCAL MICROSCOPE FOR LIVE CELL & MULTIWAVELENGTH WORK
    Mark Peifer; Fiscal Year: 2001
    ..Our proposal seeks to meet these new needs, by the creation of a multi-user facility that will provide a state-of-the art confocal microscope to a large group of NIH funded investigators. ..
  2. Evolution of insect gastrulation
    Matthew Ronshaugen; Fiscal Year: 2006
    ..It is our hope that this will lead to a specific understanding of the evolution of transcriptional regulation and to events that underlie transition of cells toward a migratory state. ..
  3. Apoptosis Signaling: BH3 to BH123 Proteins
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2008
    ..The knowledge gained would be valuable in modulating the activity of BAX in cancer and in degenerative diseases. ..
  4. SPECIFICITY OF FIBROBLAST GROWTH FACTOR SIGNALING IN DROSOPHILA
    ANGELIKE M STATHOPOULOS; Fiscal Year: 2010
    ..2) Contribution of location and timing of ligand expression to specificity. 3) Characterization of different ways in which ligands signal through the FGFR. 4) Dissection of how Htl FGFR activation by Pyr and Ths controls cell movement. ..
  5. L1-MEDIATED RECRUITMENT OF THE MEMBRANE SKELETON
    Michael Hortsch; Fiscal Year: 2002
    ..Finally, he will use this assay system to test whether mutant L1-CAM molecules from human patients will function in his assay. ..
  6. High-Volume Confocal Imaging System
    Stephen Crews; Fiscal Year: 2005
    ..The Pascal will allow the labs to expeditiously and comprehensively study the cellular basis of embryonic development in combination with existing bright-field and spinning disk microscopes. ..
  7. BH3-only protein BNIP3 in tumor progression
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2006
    ..Our results may also provide the experimental support to suggest that BNIP3 may be a new prognostic marker for human cancer. [unreadable] [unreadable]..
  8. SUMO conjugation in cell biology and Development
    Albert J Courey; Fiscal Year: 2010
    ..Consequently, the research proposed here will advance our understanding of human disease. ..
  9. Molecular Genetics of Midline Glial Development
    Stephen T Crews; Fiscal Year: 2010
    ..abstract_text> ..