sli

Summary

Gene Symbol: sli
Description: slit
Alias: CG33464, CG43758, CG8355, CT21700, CT37068, Dmel\CG43758, Dmel_CG33464, Dmel_CG8355, Sli, Slit, dSlit, fus3, l(2)05248, wdh, CG43758 gene product from transcript CG43758-RD, CG43758-PA, CG43758-PB, CG43758-PC, CG43758-PD, CG43758-PE, CG43758-PF, SGP cluster fusion defects 3, lethal (2) 05248, sli-PA, sli-PB, sli-PC, sli-PD, sli-PE, sli-PF
Species: fruit fly

Top Publications

  1. pmc A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway
    Jill J Weyers
    Department of Biology, Johns Hopkins University, 3400 N Charles St, Baltimore, MD, USA
    Dev Biol 353:217-28. 2011
  2. ncbi Neurobiology. The come-hither, don't-touch-me proteins
    G Vogel
    Science 290:2243-4. 2000
  3. ncbi Determination of cell fate along the anteroposterior axis of the Drosophila ventral midline
    Torsten Bossing
    The Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Development 133:1001-12. 2006
  4. ncbi Integrins regulate responsiveness to slit repellent signals
    Adrienne Stevens
    Department of Biology, McMaster University, Hamilton, Ontario, L8S 4K1, Canada
    J Neurosci 22:4448-55. 2002
  5. ncbi Slit and Robo control cardiac cell polarity and morphogenesis
    Li Qian
    The Burnham Institute, Center for Neuroscienes and Aging, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Curr Biol 15:2271-8. 2005
  6. pmc Structural and functional analysis of slit and heparin binding to immunoglobulin-like domains 1 and 2 of Drosophila Robo
    Noemi Fukuhara
    Department of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom
    J Biol Chem 283:16226-34. 2008
  7. ncbi The midline of the Drosophila central nervous system: a model for the genetic analysis of cell fate, cell migration, and growth cone guidance
    C Klämbt
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Cell 64:801-15. 1991
  8. ncbi slit: an EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system
    J M Rothberg
    Department of Biology, Yale University, New Haven, Connecticut 06520
    Cell 55:1047-59. 1988
  9. ncbi Control of CNS midline transcription by asymmetric E-box-like elements: similarity to xenobiotic responsive regulation
    K A Wharton
    Department of Biology, University of California, Los Angeles 90024 1570
    Development 120:3563-9. 1994
  10. ncbi Genetic analysis of Netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons
    K J Mitchell
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley California 94720, USA
    Neuron 17:203-15. 1996

Research Grants

  1. SYNAPSE STRUCTURE AND DEVELOPMENT
    W Nelson; Fiscal Year: 2001
  2. REGULATION OF NEUROGENESIS IN THE DROSOPHILA CNS
    Krishna Bhat; Fiscal Year: 2002
  3. Niemann Pick C disease in Drosophila
    Krishna Bhat; Fiscal Year: 2007
  4. Transcriptional Repression and Cofactor Recruitment
    Susan Parkhurst; Fiscal Year: 2008
  5. Mechanisms of Wound Healing in Drosphila
    Susan Parkhurst; Fiscal Year: 2009
  6. Mechanisms of Slit-Roundabout Mediated Axon Repulsion
    GREG BASHAW; Fiscal Year: 2008
  7. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    Susan Parkhurst; Fiscal Year: 2002
  8. HOW DOES VND INTEGRATE POSITIONAL INFORMATION?
    DERVLA MELLERICK DRESSLER; Fiscal Year: 2003
  9. Pancreas-specific primary regulatory targets of Nkx2.2
    DERVLA MELLERICK DRESSLER; Fiscal Year: 2004
  10. Cytoskeleton Coordination in Neuronal Morphogenesis
    W Nelson; Fiscal Year: 2005

Scientific Experts

Detail Information

Publications112 found, 100 shown here

  1. pmc A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway
    Jill J Weyers
    Department of Biology, Johns Hopkins University, 3400 N Charles St, Baltimore, MD, USA
    Dev Biol 353:217-28. 2011
    ..In addition, we discover that the Slit/Roundabout pathway, best known for its role in regulating axonal guidance, is essential for proper gonad formation...
  2. ncbi Neurobiology. The come-hither, don't-touch-me proteins
    G Vogel
    Science 290:2243-4. 2000
    Two newly discovered receptors, Slit and Roundabout (Robo), help determine how far axons in developing fruit flies travel after they cross the line between the fly's left and right sides...
  3. ncbi Determination of cell fate along the anteroposterior axis of the Drosophila ventral midline
    Torsten Bossing
    The Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Development 133:1001-12. 2006
    ..Engrailed-positive midline cells develop into ventral unpaired median (VUM) neurons and the median neuroblast (MNB). Engrailed-negative midline cells develop into unpaired median interneurons (UMI), MP1 interneurons and midline glia...
  4. ncbi Integrins regulate responsiveness to slit repellent signals
    Adrienne Stevens
    Department of Biology, McMaster University, Hamilton, Ontario, L8S 4K1, Canada
    J Neurosci 22:4448-55. 2002
    ..phenotypic interaction between genes for the integrins, their ligands, and the midline growth cone repellent, Slit, but not for the midline attractant, Netrin...
  5. ncbi Slit and Robo control cardiac cell polarity and morphogenesis
    Li Qian
    The Burnham Institute, Center for Neuroscienes and Aging, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Curr Biol 15:2271-8. 2005
    ..The extracellular-matrix molecule Slit and its Robo-family receptors are conserved regulators of axonal guidance...
  6. pmc Structural and functional analysis of slit and heparin binding to immunoglobulin-like domains 1 and 2 of Drosophila Robo
    Noemi Fukuhara
    Department of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom
    J Biol Chem 283:16226-34. 2008
    Recognition of the secreted protein Slit by transmembrane receptors of the Robo family provides important signals in the development of the nervous system and other organs, as well as in tumor metastasis and angiogenesis...
  7. ncbi The midline of the Drosophila central nervous system: a model for the genetic analysis of cell fate, cell migration, and growth cone guidance
    C Klämbt
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Cell 64:801-15. 1991
    ..A genetic test of this model has utilized a number of mutations that, by either eliminating or altering the differentiation of various midline cells, perturb the development of the axon commissures in a predictable fashion...
  8. ncbi slit: an EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system
    J M Rothberg
    Department of Biology, Yale University, New Haven, Connecticut 06520
    Cell 55:1047-59. 1988
    ..Cytological, immunocytochemical, genetic, and molecular data show that this gene corresponds to the slit locus...
  9. ncbi Control of CNS midline transcription by asymmetric E-box-like elements: similarity to xenobiotic responsive regulation
    K A Wharton
    Department of Biology, University of California, Los Angeles 90024 1570
    Development 120:3563-9. 1994
    ..These data suggest a model whereby related basic-helix-loop-helix-PAS proteins interact with asymmetric E-box-like target sequences to control these disparate processes...
  10. ncbi Genetic analysis of Netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons
    K J Mitchell
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley California 94720, USA
    Neuron 17:203-15. 1996
    ..Expression of either Netrin gene in all muscles also results in aberrant motor projections. Thus, Drosophila Netrins are required for the guidance of commissural axons at the midline, and of motor axons to their target muscles...
  11. ncbi The Drosophila SOX-domain protein Dichaete is required for the development of the central nervous system midline
    N S Soriano
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Development 125:3989-96. 1998
    ..The midline phenotypes of Dichaete mutations are rescued by expression of mouse SOX2. Our data suggest that SOX gene structure, function and interactions have been conserved during evolution...
  12. ncbi Commissure formation in the embryonic CNS of Drosophila
    T Hummel
    Institut fur Neurobiologie, Universitat Munster, Badestrasse 9, D 48149 Munster, Germany
    Development 126:771-9. 1999
    ..The results lead to a detailed model relating different cellular functions to axonal patterning at the midline...
  13. ncbi Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance
    K Brose
    Department of Anatomy, Howard Hughes Medical Institute, University of California, San Francisco 94143 0452, USA
    Cell 96:795-806. 1999
    ..Genetic analysis in Drosophila, reported in a companion to this paper, identifies the Slit protein as a candidate ligand for the repulsive guidance receptor Roundabout (Robo)...
  14. ncbi Calmodulin and son of sevenless dependent signaling pathways regulate midline crossing of axons in the Drosophila CNS
    J L Fritz
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    Development 127:1991-2000. 2000
    ..signaling pathway leads to abnormal projection of axons across the midline and these increase with roundabout or slit mutations...
  15. ncbi Functional interactions between Drosophila bHLH/PAS, Sox, and POU transcription factors regulate CNS midline expression of the slit gene
    Y Ma
    Department of Biology, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Neurosci 20:4596-605. 2000
    ..The corresponding proteins bind to DNA sites present in a 1 kb midline enhancer from the slit gene and regulate the activity of this enhancer in cultured Drosophila Schneider line 2 cells...
  16. ncbi Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor
    G J Bashaw
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 101:703-15. 2000
    ..Robo) is the founding member of a conserved family of repulsive axon guidance receptors that respond to secreted Slit proteins. Little is known about the signaling mechanisms which function downstream of Robo to mediate repulsion...
  17. ncbi Selecting a longitudinal pathway: Robo receptors specify the lateral position of axons in the Drosophila CNS
    S Rajagopalan
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Cell 103:1033-45. 2000
    ..Here we show that the midline repellent Slit, previously identified as a short-range signal that regulates midline crossing, also functions at long range to ..
  18. ncbi Short-range and long-range guidance by slit and its Robo receptors. Robo and Robo2 play distinct roles in midline guidance
    J H Simpson
    Howard Hughes Medical Institute, Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Neuron 28:753-66. 2000
    Previous studies showed that Roundabout (Robo) in Drosophila is a repulsive axon guidance receptor that binds to Slit, a repellent secreted by midline glia...
  19. ncbi Crossing the midline: roles and regulation of Robo receptors
    S Rajagopalan
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Neuron 28:767-77. 2000
    In the Drosophila CNS, the midline repellent Slit acts at short range through its receptor Robo to control midline crossing...
  20. ncbi Switching repulsion to attraction: changing responses to slit during transition in mesoderm migration
    S G Kramer
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, 519 Life Sciences Addition, University of California, Berkeley, CA 94720, USA
    Science 292:737-40. 2001
    b>Slit is secreted by cells at the midline of the central nervous system, where it binds to Roundabout (Robo) receptors and functions as a potent repellent...
  21. ncbi Short- and long-range repulsion by the Drosophila Unc5 netrin receptor
    K Keleman
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Neuron 32:605-17. 2001
    ..Ectopic expression of Unc5 on CNS axons can elicit either short- or long-range repulsion from the midline. Both short- and long-range repulsion require Netrin function, but only long-range repulsion requires Frazzled...
  22. ncbi Ectopic expression in the giant fiber system of Drosophila reveals distinct roles for roundabout (Robo), Robo2, and Robo3 in dendritic guidance and synaptic connectivity
    Tanja A Godenschwege
    Department of Biology, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Neurosci 22:3117-29. 2002
    ..We conclude that axon guidance, dendritic guidance, and synaptogenesis are separable processes and that the different Robo family members affect them distinctly...
  23. ncbi Drosophila Nedd4, a ubiquitin ligase, is recruited by Commissureless to control cell surface levels of the roundabout receptor
    Anna Myat
    Molecular Neurobiology Group, MRC Centre for Developmental Neurobiology, King s College London, New Hunt s House, Guy s Campus, London SE1 1UL, United Kingdom
    Neuron 35:447-59. 2002
    ..Our results show that changes in axonal sensitivity to external cues during pathfinding across the midline makes use of ubiquitin-dependent mechanisms to regulate transmembrane protein levels...
  24. ncbi Dephrin, a transmembrane ephrin with a unique structure, prevents interneuronal axons from exiting the Drosophila embryonic CNS
    Torsten Bossing
    Wellcome Trust Cancer Research UK Institute and Department of Genetics, Cambridge University, Tennis Court Road, Cambridge, CB2 1QR, UK
    Development 129:4205-18. 2002
    ..We propose that the longitudinal tracts in the Drosophila CNS are moulded by a repulsive outer border of Dephrin expression...
  25. ncbi Activation of the repulsive receptor Roundabout inhibits N-cadherin-mediated cell adhesion
    Jinseol Rhee
    Department of Biological Sciences, The University of Iowa, Iowa City, IA 52242, USA
    Nat Cell Biol 4:798-805. 2002
    ..activation of the transmembrane receptor Roundabout (Robo) by its ligand, the secreted repulsive guidance cue Slit, inactivates N-cadherin-mediated adhesion...
  26. ncbi Attractive and repulsive functions of Slit are mediated by different receptors in the Drosophila trachea
    Camilla Englund
    Umea Centre for Molecular Pathogenesis, Umea University, Sweden
    Development 129:4941-51. 2002
    ..b>Slit, a phylogenetically conserved axonal guidance signal, is expressed in several tracheal targets and is required both ..
  27. ncbi Genetic specification of axonal arbors: atonal regulates robo3 to position terminal branches in the Drosophila nervous system
    Marta Zlatic
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, United Kingdom
    Neuron 37:41-51. 2003
    ..chordotonal neurons) or nonexpression (multidendritic neurons) of the Robo3 receptor for the midline repellent Slit. Robo3 expression is one of a suite of chordotonal neuron properties that depend on expression of the proneural ..
  28. ncbi Heparan sulfate proteoglycan syndecan promotes axonal and myotube guidance by slit/robo signaling
    Patrick Steigemann
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Am Fassberg 11, 37077 Goettingen, Germany
    Curr Biol 14:225-30. 2004
    b>Slit, the ligand for the Roundabout (Robo) receptors, is secreted from midline cells of the Drosophila central nervous system (CNS)...
  29. ncbi Axonal heparan sulfate proteoglycans regulate the distribution and efficiency of the repellent slit during midline axon guidance
    Karl G Johnson
    Harvard Medical School, Department of Cell Biology, Program in Neuroscience, 240 Longwood Avenue, Boston, MA 02115, USA
    Curr Biol 14:499-504. 2004
    ..Here we demonstrate through genetic analysis in vivo that the HSPG Syndecan (Sdc) is critical for the fidelity of Slit repellent signaling at the midline of the Drosophila CNS, consistent with the localization of Sdc to CNS axons...
  30. pmc Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons
    Annika Lundström
    Department of Developmental Biology, Wenner Gren Institute, Stockholm University, S 106 96 Stockholm, Sweden
    Genes Dev 18:2161-71. 2004
    b>Slit proteins steer the migration of many cell types through their binding to Robo receptors, but how Robo controls cell motility is not clear...
  31. ncbi Comm function in commissural axon guidance: cell-autonomous sorting of Robo in vivo
    Krystyna Keleman
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5, A 1030 Vienna, Austria
    Nat Neurosci 8:156-63. 2005
    ..the Drosophila melanogaster midline by regulating surface levels of Robo, the receptor for the midline repellent Slit. Two different models have been proposed for how Comm regulates Robo: a 'sorting' model and a 'clearance' model, ..
  32. ncbi Patched regulation of axon guidance is by specifying neural identity in the Drosophila nerve cord
    Tanuja T Merianda
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Dev Genes Evol 215:285-96. 2005
    ..Interestingly, the medial tracts cross the midline ignoring the axon-repellant Slit on the midline and Roundabout on growth cones. The medial tract is pioneered by neurons pCC and vMP2...
  33. ncbi Slit coordinates cardiac morphogenesis in Drosophila
    Allison MacMullin
    Department of Biology, McMaster University, LSB 429, 1280 Main St W, Hamilton, ON, Canada L8S 4K1
    Dev Biol 293:154-64. 2006
    b>Slit is a secreted guidance cue that conveys repellent or attractive signals from target and guidepost cells. In Drosophila, responsive cells express one or more of three Robo receptors...
  34. pmc Lateral positioning at the dorsal midline: Slit and Roundabout receptors guide Drosophila heart cell migration
    EDGARDO SANTIAGO-MARTINEZ
    Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 675 Hoes Lane West, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 103:12441-6. 2006
    ..In this study, we analyzed the role of Slit, an extracellular matrix protein and its transmembrane receptors Roundabout (Robo) and Roundabout2 (Robo2) during ..
  35. ncbi Son of sevenless directly links the Robo receptor to rac activation to control axon repulsion at the midline
    Long Yang
    Department of Neuroscience, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Neuron 52:595-607. 2006
    ..SH3-SH2 adaptor protein Dreadlocks (Dock) to regulate Rac-dependent cytoskeletal rearrangement in response to the Slit ligand...
  36. pmc Regulation of axon guidance by slit and netrin signaling in the Drosophila ventral nerve cord
    Krishna Moorthi Bhat
    Department of Neuroscience and Cell Biology, School of Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA
    Genetics 176:2235-46. 2007
    Netrin and Slit signaling systems play opposing roles during the positioning of longitudinal tracts along the midline in the ventral nerve cord of Drosophila embryo...
  37. ncbi Cables links Robo-bound Abl kinase to N-cadherin-bound beta-catenin to mediate Slit-induced modulation of adhesion and transcription
    Jinseol Rhee
    Department of Biological Sciences, The University of Iowa, Iowa City, Iowa 52242 1324, USA
    Nat Cell Biol 9:883-92. 2007
    Binding of the secreted axon guidance cue Slit to its Robo receptor results in inactivation of the neural, calcium-dependent cell-cell adhesion molecule N-cadherin, providing a rapid epigenetic mechanism for integrating guidance and ..
  38. ncbi Slit and Robo control the development of dendrites in Drosophila CNS
    Marie Pierre Furrer
    Department of Cell and Developmental Biology, University of Illinois, Urbana, IL 61801, USA
    Development 134:3795-804. 2007
    The molecular mechanisms that generate dendrites in the CNS are poorly understood. The diffusible signal molecule Slit and the neuronally expressed receptor Robo mediate growth cone collapse in vivo...
  39. pmc Genetic control of cell morphogenesis during Drosophila melanogaster cardiac tube formation
    Caroline Medioni
    Institut de Biologie du Developpement de Marseille Luminy, Centre National de la Recherche Scientifique UMR 6216, Universite de la Mediterranee, 13288 Marseille, Cedex 9, France
    J Cell Biol 182:249-61. 2008
    ..Furthermore, we identify a genetic pathway in which roundabout, slit, held out wings, and dystroglycan control cardiac lumen formation by establishing nonadherent luminal membranes and ..
  40. doi Slit and Robo regulate dendrite branching and elongation of space-filling neurons in Drosophila
    Svetla Dimitrova
    Dendrite Differentiation, Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Munich, Germany
    Dev Biol 324:18-30. 2008
    ..In this study we show that a member of the conserved Robo receptor family, Robo, and its ligand Slit regulate the dendritic differentiation of space-filling neurons...
  41. pmc Midline governs axon pathfinding by coordinating expression of two major guidance systems
    Qing Xin Liu
    Department of Developmental Genetics, National Institute of Genetics, Mishima, Shizuoka 411 8540, Japan
    Genes Dev 23:1165-70. 2009
    ..protein Midline controls expression of genes encoding components of two major guidance systems: Frazzled, ROBO, and Slit. In midline mutant, expression of all these molecules are reduced, resulting in severe axon guidance defects, ..
  42. pmc Role of serotonergic neurons in the Drosophila larval response to light
    Verónica G Rodriguez Moncalvo
    Department of Biology, McMaster University, 1280 Main St, West, Hamilton, ON, L8S 4K1, Canada
    BMC Neurosci 10:66. 2009
    ..Thus, Drosophila larval photobehavior can be used to study control of locomotion...
  43. pmc Reception of Slit requires only the chondroitin-sulphate-modified extracellular domain of Syndecan at the target cell surface
    Bhavna Chanana
    Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Am Fassberg 11, 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 106:11984-8. 2009
    ..In Drosophila, Sdc has been shown to be necessary for Slit signaling-dependent axon and myotube guidance during CNS development and muscle pattern formation...
  44. pmc Functional diversity of Robo receptor immunoglobulin domains promotes distinct axon guidance decisions
    Timothy A Evans
    Department of Neuroscience, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Curr Biol 20:567-72. 2010
    ..In Drosophila, three Roundabout (Robo) Ig superfamily receptors respond to their common Slit ligand to regulate axon guidance at the midline: Robo and Robo2 mediate midline repulsion, Robo2 and Robo3 control ..
  45. pmc Interdependence of macrophage migration and ventral nerve cord development in Drosophila embryos
    Iwan R Evans
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, UK
    Development 137:1625-33. 2010
    ..Using live imaging, we demonstrate that the axonal guidance cue Slit and its receptor Robo are both required for haemocyte migration, but signalling is not autonomously required in ..
  46. doi The transmembrane receptor Uncoordinated5 (Unc5) is essential for heart lumen formation in Drosophila melanogaster
    Stefanie Albrecht
    Universitat Osnabruck, Fachbereich Biologie Chemie Zoologie Entwicklungsbiologie, Barbarastraße 11, 49069 Osnabruck, Germany
    Dev Biol 350:89-100. 2011
    ..Our findings support the idea that Unc5 is crucial for lumen formation and thereby represents a repulsive cue acting during Drosophila heart tube formation...
  47. doi Syndecan contributes to heart cell specification and lumen formation during Drosophila cardiogenesis
    Jessica Knox
    Department of Biology, McMaster University, 1280 Main St W, Hamilton, Ontario, Canada
    Dev Biol 356:279-90. 2011
    ..surface signaling of diverse ligands in mammals, yet in Drosophila, genetic evidence links Syndecan only to the Slit receptor Roundabout and to the receptor tyrosine phosphatase LAR...
  48. pmc Integrins are required for cardioblast polarisation in Drosophila
    Jessica Vanderploeg
    Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada
    BMC Dev Biol 12:8. 2012
    ..Here we characterise the requirement of Integrins in a genetic model of vasculogenesis, the formation of the heart in Drosophila...
  49. ncbi slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains
    J M Rothberg
    Howard Hughes Medical Institute, Departments of Cell Biology and Biology, Yale University, New Haven, Connecticut
    Genes Dev 4:2169-87. 1990
    The Drosophila slit locus encodes a protein with four regions containing tandem arrays of a 24-amino-acid leucine-rich repeat (LRR) with conserved flanking sequences (flank-LRR-flank surrounding these arrays), followed by two regions with ..
  50. ncbi Slit is the midline repellent for the robo receptor in Drosophila
    T Kidd
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 96:785-94. 1999
    ..Here we present genetic evidence that Slit is the midline Robo ligand; a companion paper presents biochemical evidence that Slit binds Robo...
  51. ncbi Chimeric axon guidance receptors: the cytoplasmic domains of slit and netrin receptors specify attraction versus repulsion
    G J Bashaw
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 97:917-26. 1999
    Frazzled (Fra) is the DCC-like Netrin receptor in Drosophila that mediates attraction; Roundabout (Robo) is a Slit receptor that mediates repulsion...
  52. ncbi Abelson tyrosine kinase is required to transduce midline repulsive cues
    Anita Hsouna
    Department of Biological Sciences, Wayne State University, 5047 Gullen Mall, Detroit, Michigan 48202, USA
    J Neurobiol 57:15-30. 2003
    ..The frequency of abnormal crossovers is enhanced by mutations in the genes encoding the midline repellent, Slit, or its receptor, Roundabout...
  53. ncbi Muscle-dependent maturation of tendon cells is induced by post-transcriptional regulation of stripeA
    Gloria Volohonsky
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Development 134:347-56. 2007
    ..Thus, we demonstrate a mechanism by which tendon cell terminal differentiation is maintained and reinforced by the approaching muscle...
  54. pmc Repulsion by Slit and Roundabout prevents Shotgun/E-cadherin-mediated cell adhesion during Drosophila heart tube lumen formation
    EDGARDO SANTIAGO-MARTINEZ
    Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
    J Cell Biol 182:241-8. 2008
    ..We show that Slit and its receptor Roundabout (Robo) are required at CB apical domains for lumen formation...
  55. ncbi Mesectodermal cell fate analysis in Drosophila midline mutants
    M J Sonnenfeld
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Mech Dev 46:3-13. 1994
    ..of commissures, leading to longitudinal tract collapse, was seen in embryos mutant for the genes single-minded and slit. MEC lineages did not survive in single-minded mutant embryos, in contrast to the survival of all MEC lineages in ..
  56. ncbi Axon repulsion from the midline of the Drosophila CNS requires slit function
    R Battye
    Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    Development 126:2475-81. 1999
    ..Here we demonstrate that Slit, a protein secreted by the midline glial cells provides a repulsive cue for the growth cones of axons and muscle ..
  57. ncbi Differential expression and function of the Drosophila Pax6 genes eyeless and twin of eyeless in embryonic central nervous system development
    L Kammermeier
    Institute of Zoology, Biocenter Pharmacenter, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Mech Dev 103:71-8. 2001
    ..In contrast, targeted misexpression of ey, but not of toy, resulted in profound axonal abnormalities in the embryonic ventral nerve cord and brain...
  58. ncbi Movement through Slits: cellular migration via the Slit family
    Michael Piper
    Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
    Bioessays 25:32-8. 2003
    First isolated in the fly and now characterised in vertebrates, the Slit proteins have emerged as pivotal components controlling the guidance of axonal growth cones and the directional migration of neuronal precursors...
  59. pmc Tube morphogenesis: closure, but many openings remain
    W James Nelson
    Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305 5435, USA
    Trends Cell Biol 13:615-21. 2003
    ..This review provides a summary of these pathways based upon articles published in the Tube Morphogenesis Series in Trends in Cell Biology...
  60. ncbi The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance
    Haeryun Lee
    Department of Cell Biology, Program in Neuroscience, Dana Farber Cancer Institute Harvard Cancer Center and Harvard Center of Neurodegeneration and Repair, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Neuron 42:913-26. 2004
    ..We find identical axon guidance phenotypes in orbit/MAST and Abl mutants at the midline, where the repellent Slit restricts axon crossing...
  61. pmc Binding site for Robo receptors revealed by dissection of the leucine-rich repeat region of Slit
    Jason A Howitt
    Department of Biological Sciences, Imperial College London, London, UK
    EMBO J 23:4406-12. 2004
    Recognition of the large secreted protein Slit by receptors of the Robo family provides fundamental signals in axon guidance and other developmental processes...
  62. pmc Control of lateral migration and germ cell elimination by the Drosophila melanogaster lipid phosphate phosphatases Wunen and Wunen 2
    Hiroko Sano
    Department of Cell Biology, Developmental Genetics Program, Skirball Institute of Biomolecular Medicine and Howard Hughes Medical Institute, New York University Medical Center, New York, NY 10016
    J Cell Biol 171:675-83. 2005
    ..Our results suggest that expression of wun/wun-2 repellents along the migratory paths provides faithful control over the sorting of PGCs into two gonads and eliminates PGCs left in the middle of the embryo...
  63. pmc The phosphoinositide phosphatase Sac1 is required for midline axon guidance
    Seongsoo Lee
    Department of Cell and Developmental Biology, Dental Research Institute, School of Dentistry, Seoul National University, Seoul 110 749, Korea
    Mol Cells 32:477-82. 2011
    ..sac1 displays dosage-sensitive genetic interactions with mutations in the genes that encode the midline repellent Slit and its axonal receptor Robo...
  64. pmc The DOCK protein sponge binds to ELMO and functions in Drosophila embryonic CNS development
    Bridget Biersmith
    Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri, Kansas City, Missouri, United States of America
    PLoS ONE 6:e16120. 2011
    ..Our findings not only characterize the role of a new DOCK family member, but help to further understand the role of signaling downstream of N-cadherin in neuronal development...
  65. ncbi Drosophila extracellular matrix
    L I Fessler
    Department of Biology, University of California at Los Angeles 90024, USA
    Methods Enzymol 245:271-94. 1994
  66. ncbi Perturbed glial scaffold formation precedes axon tract malformation in Drosophila mutants
    J R Jacobs
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    J Neurobiol 24:611-26. 1993
    ..The longitudinal tracts in embryos mutant for slit fused at the VNC midline and scaffold formation was normal, except that it was medially displaced...
  67. ncbi CNS midline enhancers of the Drosophila slit and Toll genes
    K A Wharton
    Molecular Biology Institute, University of California, Los Angeles 90024
    Mech Dev 40:141-54. 1993
    ..Using germ-line transformation of lacZ fusion constructs, we have dissected putative regulatory regions of the slit and Toll genes to identify CNS midline-restricted transcriptional enhancers...
  68. ncbi CNS midline to mesoderm signaling in Drosophila
    L Zhou
    Program for Neuroscience and Behavior, University of Massachusetts at Amherst, 01003, USA
    Mech Dev 67:59-68. 1997
    ..Thus, dorsal median cells fail to form in single-minded mutants and do not persist in slit mutants...
  69. ncbi Control of cell lineage-specific development and transcription by bHLH-PAS proteins
    S T Crews
    Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7260 USA
    Genes Dev 12:607-20. 1998
  70. pmc Genes regulating dendritic outgrowth, branching, and routing in Drosophila
    F B Gao
    Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California at San Francisco, San Francisco, California 94143 0725, USA
    Genes Dev 13:2549-61. 1999
    ..These findings begin to reveal the molecular mechanisms controlling dendritic morphogenesis...
  71. ncbi Slit proteins: key regulators of axon guidance, axonal branching, and cell migration
    K Brose
    Departments of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 0452, USA
    Curr Opin Neurobiol 10:95-102. 2000
    In the past year, Slit proteins have been identified as important regulators of axon guidance and cell migration in Drosophila and vertebrates...
  72. ncbi Putting on the brakes: a negative regulatory function for Ena/VASP proteins in cell migration
    L M Machesky
    School of Biosciences, Division of Molecular and Cell Biology, University of Birmingham, United Kingdom
    Cell 101:685-8. 2000
  73. ncbi Repellent signaling by Slit requires the leucine-rich repeats
    R Battye
    Department of Biology, McMaster University, Hamilton Ontario, L8S 4K1 Canada
    J Neurosci 21:4290-8. 2001
    b>Slit is a repellent axon guidance cue produced by the midline glia in Drosophila that is required to regulate the formation of contralateral projections and the lateral position of longitudinal tracts...
  74. ncbi Slit signaling promotes the terminal asymmetric division of neural precursor cells in the Drosophila CNS
    B Mehta
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Development 128:3161-8. 2001
    ..Here, we show that the midline repellent Slit (Sli), via its receptor Roundabout (Robo), promotes the terminal asymmetric division of GMCs...
  75. ncbi Regulation of cell number by MAPK-dependent control of apoptosis: a mechanism for trophic survival signaling
    Andreas Bergmann
    Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Dev Cell 2:159-70. 2002
    ..Therefore, a direct pathway linking a specific extracellular survival factor with a caspase-based death program has been established...
  76. ncbi Lola regulates midline crossing of CNS axons in Drosophila
    Daniel Crowner
    Division of Basic Sciences, Program in Developmental Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, N, Seattle, WA 98109, USA
    Development 129:1317-25. 2002
    ..axons away from the midline, and that it acts, in part, by augmenting the expression both of the midline repellant, Slit, and of its axonal receptor, Robo...
  77. ncbi Axon guidance: the cytoplasmic tail
    Bharatkumar N Patel
    Program in Neuroscience, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Cell Biol 14:221-9. 2002
    ..Recent studies demonstrate a critical role for the cytoplasmic tails of guidance receptors in signalling and also reveal the potential for a great deal of crosstalk between the various receptor-signalling pathways...
  78. ncbi The jing Zn-finger transcription factor is a mediator of cellular differentiation in the Drosophila CNS midline and trachea
    Yalda Sedaghat
    Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ontario K1H 8M5, Canada
    Development 129:2591-606. 2002
    ..and trachea, with mutations in the bHLH-PAS genes single-minded and trachealess, and their downstream target genes (slit and breathless)...
  79. ncbi Constitutively active myosin light chain kinase alters axon guidance decisions in Drosophila embryos
    You Seung Kim
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
    Dev Biol 249:367-81. 2002
    ..Mutations in the midline repulsive ligand Slit, or its receptor Roundabout, enhance the number of ctMLCK-induced crossovers, but ctMLCK expression also partially ..
  80. ncbi Axon targeting meets protein trafficking: Comm takes Robo to the cleaners
    Mark Rosenzweig
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Dev Cell 3:301-2. 2002
    ..Recent findings demonstrate that Comm collaborates with the ubiquitin-protein ligase DNedd4 to inhibit Robo signaling by promoting the sorting of Robo into the endocytic pathway...
  81. ncbi Axon guidance: Comm hither, Robo
    Jessica Couch
    Department of Biology, 071 Gilmer Hall, University of Virginia, Charlottesville, VA 22903, USA
    Curr Biol 12:R741-2. 2002
    ..Recent studies have shed new light on the mechanism by which commissural axons change their sensitivity to guidance cues after crossing the midline...
  82. ncbi A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding
    Zachary Wills
    Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Neuron 36:611-22. 2002
    ..and specific genetic interaction between capt and Abl at the midline choice point where the growth cone repellent Slit functions to restrict axon crossing...
  83. ncbi Embryo morphogenesis: getting down to cells and molecules
    Lila Solnica-Krezel
    Vanderbilt University, VU Station B 351634, Nashville, TN 37235 1634, USA
    Development 130:4229-33. 2003
  84. ncbi Rhomboid 3 orchestrates Slit-independent repulsion of tracheal branches at the CNS midline
    Marco Gallio
    Department of Developmental Biology, Wenner Gren Institute, Stockholm University, S 106 96 Stockholm, Sweden
    Development 131:3605-14. 2004
    ..rho3 acts independently from the main midline repellent Slit, and originates from a different sub-population of midline cells: the VUM neurons...
  85. ncbi Neurons and glia: team players in axon guidance
    Carole Chotard
    National Institute for Medical Research, Division of Molecular Neurobiology, The Ridgeway, London NW7 1AA, UK
    Trends Neurosci 27:655-61. 2004
    ..Equally, neurons provide crucial information to glia, supporting their migration and correct positioning...
  86. ncbi The apical caspase dronc governs programmed and unprogrammed cell death in Drosophila
    Su Kit Chew
    Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Dev Cell 7:897-907. 2004
    ..These findings establish dronc as an essential regulator of cell number in development and illustrate broad requirements for this apical caspase in adaptive responses during stress-induced apoptosis...
  87. pmc Slit-roundabout signaling neutralizes netrin-Frazzled-mediated attractant cue to specify the lateral positioning of longitudinal axon pathways
    Krishna Moorthi Bhat
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322
    Genetics 170:149-59. 2005
    ..However, the midline Slit neutralizes this pathway in a Robo-dependent manner and prevents Netrin-Frazzled-mediated attraction of ..
  88. pmc A molecular mechanism for the heparan sulfate dependence of slit-robo signaling
    Sadaf Ahmahni Hussain
    Division of Cell and Molecular Biology, Imperial College London, London, UK
    J Biol Chem 281:39693-8. 2006
    b>Slit is a large secreted protein that provides important guidance cues in the developing nervous system and in other organs. Signaling by Slit requires two receptors, Robo transmembrane proteins and heparan sulfate (HS) proteoglycans...
  89. ncbi Different Wnt signals act through the Frizzled and RYK receptors during Drosophila salivary gland migration
    Katherine E Harris
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Development 134:2017-25. 2007
    ..Our results suggest that both the Wnt4-frizzled pathway and a separate Wnt5-derailed pathway are needed for proper salivary gland migration...
  90. doi Induction of cellular growth by the axon guidance regulators netrin A and semaphorin-1a
    Ellen Flannery
    Department of Biological Sciences, Walther Cancer Institute, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Dev Neurobiol 70:473-84. 2010
    ..The abilities of NetA and Sema1a to regulate cellular growth are likely critical to their functions in both nervous system development and oncogenesis...
  91. pmc Mechanosensilla in the adult abdomen of Drosophila: engrailed and slit help to corral the peripheral sensory axons into segmental bundles
    Caroline C G Fabre
    Department of Zoology, University of Cambridge, Cambridge, UK
    Development 137:2885-94. 2010
    ..We then searched for the engrailed-dependent agent responsible for these repellent properties. We found slit to be expressed in the P compartment and, using genetic mosaics, present evidence that Slit is the responsible ..
  92. ncbi The paired box gene pox neuro: a determinant of poly-innervated sense organs in Drosophila
    C Dambly-Chaudiere
    Laboratoire de Genetique, Universite Libre de Bruxelles, Rhode Saint Genese, Belgium
    Cell 69:159-72. 1992
    ..Expression of poxn in the wing disc is restricted to the SMCs of the poly-innervated sense organs, suggesting that poxn also determines the lineage of poly-innervated adult sense organs...
  93. ncbi Drosophila single-minded gene and the molecular genetics of CNS midline development
    S Crews
    Department of Biology, University of California, Los Angeles 90024
    J Exp Zool 261:234-44. 1992
    ..This should permit elucidation of the genetic hierarchy which acts in the specification, differentiation, and function of these CNS midline cells...
  94. ncbi Use of high coverage reference libraries of Drosophila melanogaster for relational data analysis. A step towards mapping and sequencing of the genome
    J D Hoheisel
    Imperial Cancer Research Fund, Lincoln s Inn Fields, London, U K
    J Mol Biol 220:903-14. 1991
    ..cDNA clones are further examined by a partial sequencing analysis by oligomer hybridization...
  95. ncbi The single-minded gene of Drosophila is required for the expression of genes important for the development of CNS midline cells
    J R Nambu
    Department of Biology, University of California, Los Angeles 90024
    Cell 63:63-75. 1990
    ..We further present evidence that sim is required for midline expression of a group of genes including slit, Toll, rhomboid, engrailed, and a gene at 91F; that the sim mutant CNS defect may be largely due to loss of midline ..
  96. ncbi Function of ets genes is conserved between vertebrates and Drosophila
    O Albagli
    INSERM U124, IRCL, Lille, France
    Mech Dev 59:29-40. 1996
    ....
  97. ncbi Axon guidance: starting and stopping with slit
    S Guthrie
    Department of Developmental Neurobiology, Hodgkin Building King s College, Guy s Campus, London, SE1 9RT, UK
    Curr Biol 9:R432-5. 1999
    ..Now, the Slit protein has been discovered to have striking positive and negative effects on axon growth and guidance.
  98. ncbi Axon guidance at the central nervous system midline
    G Tear
    Molecular Neurobiology Group, Guy s Hospital Campus, King s College, London
    Cell Mol Life Sci 55:1365-76. 1999
    ..In this way, axons extend toward or away from the midline and those that do cross change their behaviour to respond to longitudinal signals on the contralateral side...
  99. ncbi Rhomboid function in the midline of the Drosophila CNS
    B R Lanoue
    Department of Biology, McMaster University, Hamilton, Canada
    Dev Genet 25:321-30. 1999
    ..Although rho misexpression can increase MG number through a non-cell autonomous mechanism, the pattern of normal rho expression suggests that it functions by enhancing autocrine or paracrine signaling among MG cells...
  100. ncbi Receptor tyrosine phosphatases regulate axon guidance across the midline of the Drosophila embryo
    Q Sun
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Development 127:801-12. 2000
    ..Repulsion is thought to be triggered by binding of the secreted protein Slit, which is expressed by midline glia, to Roundabout (Robo) receptors on growth cones...
  101. ncbi Protein-protein interactions define specificity in signal transduction
    T Pawson
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    Genes Dev 14:1027-47. 2000

Research Grants15

  1. SYNAPSE STRUCTURE AND DEVELOPMENT
    W Nelson; Fiscal Year: 2001
    ..This research will aid in the prevention of psychiatric illness and the development of therapies for afflicted individuals. ..
  2. REGULATION OF NEUROGENESIS IN THE DROSOPHILA CNS
    Krishna Bhat; Fiscal Year: 2002
    ..These studies will help understand pathways that govern the lineage elaboration in the Drosophila CNS as well as in other eukaryotic organisms including humans. ..
  3. Niemann Pick C disease in Drosophila
    Krishna Bhat; Fiscal Year: 2007
    ..This work will provide insight into the role of these proteins in neurodegenerative diseases and development. ..
  4. Transcriptional Repression and Cofactor Recruitment
    Susan Parkhurst; Fiscal Year: 2008
    ..Results obtained from these projects are expected to have wide implications as HES family proteins and mechanisms of transcriptional repression are conserved throughout organisms. ..
  5. Mechanisms of Wound Healing in Drosphila
    Susan Parkhurst; Fiscal Year: 2009
    ..Controlling repair and inflammation will also be a fundamental consideration in tissue engineering where artificial and/or cell based constructs are implanted to reconstruct tissues. ..
  6. Mechanisms of Slit-Roundabout Mediated Axon Repulsion
    GREG BASHAW; Fiscal Year: 2008
    ..In the Drosophila CNS, the conserved guidance cue Slit and its neuronal receptors the Roundabouts (Robo), play multiple roles in patterning axonal connections at the ..
  7. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    Susan Parkhurst; Fiscal Year: 2002
    ..Results obtained from these projects are expected to have wide implications as Hairy/E(spl) proteins and mechanisms of transcriptional repression are conserved throughout organisms. ..
  8. HOW DOES VND INTEGRATE POSITIONAL INFORMATION?
    DERVLA MELLERICK DRESSLER; Fiscal Year: 2003
    ..These studies address the structure and function of vnd, a critical regulator of early neuronal development, and may serve as a prototype for vertebrate vnd-like genes. ..
  9. Pancreas-specific primary regulatory targets of Nkx2.2
    DERVLA MELLERICK DRESSLER; Fiscal Year: 2004
    ..2 target genes. This knowledge may be highly instructive in defining those regulatory networks required for beta islet specification. ..
  10. Cytoskeleton Coordination in Neuronal Morphogenesis
    W Nelson; Fiscal Year: 2005
    ....
  11. High-Volume Confocal Imaging System
    Stephen Crews; Fiscal Year: 2005
    ..The Pascal will allow the labs to expeditiously and comprehensively study the cellular basis of embryonic development in combination with existing bright-field and spinning disk microscopes. ..
  12. Mechanisms of Rho GTPase Function in Drosophila
    Susan Parkhurst; Fiscal Year: 2006
    ..Our results are expected to have wide implications as Rho GTPases and the diverse cellular mechanisms they mediate are conserved across a wide range of organisms. ..
  13. Genes Essential To Motor Axon Guidance in Drosophila
    David Van Vactor; Fiscal Year: 2009
    ..Analysis of the effector protein CLASP has defined a pathway from the repellent factor Slit and its Roundabout receptors, to the Abelson tyrosine kinase, to CLASP, as a means of impeding microtubule and ..
  14. Regulation of Cell Migration by the APC-Microtubule Complex
    William Nelson; Fiscal Year: 2009
    ..abstract_text> ..
  15. Molecular Genetics of Midline Glial Development
    Stephen T Crews; Fiscal Year: 2010
    ..abstract_text> ..