shg

Summary

Gene Symbol: shg
Description: shotgun
Alias: CADH, CG3722, CT12481, Cad, CadE, Cadh, D E-cad, D-CAD2, D-cad, DCAD, DCAD2, DCad, DCad2, DE Cad, DE Cadh, DE-CAD, DE-CAD2, DE-Cad, DE-Cad2, DE-Cadh, DE-Cadherin, DE-cad, DE-cadh, DE-cadherin, DEC, DECAD, DECad, DECadh, DE[cyto], DEcad, De-Cad, Dmel\CG3722, E-CAD, E-Ca, E-Cad, E-Cadherin, E-cad, E-cadherin, ECAD, ECad, ECad2, ECadh, Ecad, N-cad, Shg, cad, cadh, com5, dEcad, de-cad, e-cad, ecad, gp150, l(2)10469, l(2)k03401, l(2)k10220, shg/DE-Cad, CG3722 gene product from transcript CG3722-RA, (DE)-cadherin, CG3722-PA, Cadherin-E, D-Ecadherin, D-cadherin, DCAD2, DE cadherin, DE-cad, DE-cadherin/Shotgun, DEcad, DEcadherin, De-cadherin, ECadherin, Shotgun/E-cadherin, cadherin, compaction defects 5, drosophila E-cadherin, drosophila epithelial cadherin, drosophila melanogaster epithelial (DE)-cadherin, e-cadherin, epithelial cadherin, eta-catenin, shg-PA
Species: fruit fly

Top Publications

  1. ncbi Localization of apical epithelial determinants by the basolateral PDZ protein Scribble
    D Bilder
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 403:676-80. 2000
  2. pmc Pulsed contractions of an actin-myosin network drive apical constriction
    Adam C Martin
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nature 457:495-9. 2009
  3. pmc Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration
    Brian Stramer
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK
    J Cell Biol 168:567-73. 2005
  4. pmc Myosin II dynamics are regulated by tension in intercalating cells
    Rodrigo Fernandez-Gonzalez
    Howard Hughes Medical Institute, Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065 USA
    Dev Cell 17:736-43. 2009
  5. pmc Rho-kinase directs Bazooka/Par-3 planar polarity during Drosophila axis elongation
    Sérgio de Matos Simões
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA
    Dev Cell 19:377-88. 2010
  6. pmc PAR-1 kinase regulates epithelial detachment and directional protrusion of migrating border cells
    Jocelyn A McDonald
    Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Curr Biol 18:1659-67. 2008
  7. pmc Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway
    Julian C Boggiano
    Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA
    Dev Cell 21:888-95. 2011
  8. ncbi Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation
    Claire Bertet
    Laboratoire de Genetique et de Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, CNRS Inserm Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 9, France
    Nature 429:667-71. 2004
  9. doi Nature and anisotropy of cortical forces orienting Drosophila tissue morphogenesis
    Matteo Rauzi
    Institut Fresnel, Université Aix Marseille III, CNRS, Ecole Centrale Marseille, UMR 6133, Domaine universitaire de St Jerome, 13397 Marseille Cedex 20, France
    Nat Cell Biol 10:1401-10. 2008
  10. doi Dpp signaling promotes the cuboidal-to-columnar shape transition of Drosophila wing disc epithelia by regulating Rho1
    Thomas J Widmann
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany
    J Cell Sci 122:1362-73. 2009

Research Grants

Detail Information

Publications191 found, 100 shown here

  1. ncbi Localization of apical epithelial determinants by the basolateral PDZ protein Scribble
    D Bilder
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 403:676-80. 2000
    ..Our results show that the lateral domain of epithelia, particularly the septate junction, functions in restricting apical membrane identity and correctly placing adherens junctions...
  2. pmc Pulsed contractions of an actin-myosin network drive apical constriction
    Adam C Martin
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nature 457:495-9. 2009
    ..Our results suggest a new model for apical constriction in which a cortical actin-myosin cytoskeleton functions as a developmentally controlled subcellular ratchet to reduce apical area incrementally...
  3. pmc Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration
    Brian Stramer
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK
    J Cell Biol 168:567-73. 2005
    ..Cdc42 is necessary for maintaining cellular polarity and yet, despite in vitro evidence, is dispensable for sensing and crawling toward wound cues...
  4. pmc Myosin II dynamics are regulated by tension in intercalating cells
    Rodrigo Fernandez-Gonzalez
    Howard Hughes Medical Institute, Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065 USA
    Dev Cell 17:736-43. 2009
    ..These results demonstrate that myosin II dynamics are regulated by tension in a positive feedback loop that leads to multicellular actomyosin cable formation and efficient tissue elongation...
  5. pmc Rho-kinase directs Bazooka/Par-3 planar polarity during Drosophila axis elongation
    Sérgio de Matos Simões
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA
    Dev Cell 19:377-88. 2010
    ..These results demonstrate that Rho-kinase plays an instructive role in planar polarity by targeting Baz/Par-3 and myosin II to complementary cortical domains...
  6. pmc PAR-1 kinase regulates epithelial detachment and directional protrusion of migrating border cells
    Jocelyn A McDonald
    Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Curr Biol 18:1659-67. 2008
    ....
  7. pmc Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway
    Julian C Boggiano
    Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA
    Dev Cell 21:888-95. 2011
    ..These results demonstrate that one family of Ste20 kinases can activate another and identify Tao-1 as a component of the regulatory network controlling HSW pathway signaling, and therefore tissue growth, during development...
  8. ncbi Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation
    Claire Bertet
    Laboratoire de Genetique et de Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, CNRS Inserm Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 9, France
    Nature 429:667-71. 2004
    ..This simple cellular mechanism provides a general model for polarized morphogenesis in epithelial organs...
  9. doi Nature and anisotropy of cortical forces orienting Drosophila tissue morphogenesis
    Matteo Rauzi
    Institut Fresnel, Université Aix Marseille III, CNRS, Ecole Centrale Marseille, UMR 6133, Domaine universitaire de St Jerome, 13397 Marseille Cedex 20, France
    Nat Cell Biol 10:1401-10. 2008
    ..We delineate the contribution of subcellular tensile activity polarizing junction remodelling, and the permissive role of vertex fluctuations during tissue elongation...
  10. doi Dpp signaling promotes the cuboidal-to-columnar shape transition of Drosophila wing disc epithelia by regulating Rho1
    Thomas J Widmann
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany
    J Cell Sci 122:1362-73. 2009
    ..Our results identify a cell-autonomous role for Dpp signaling in promoting and maintaining the elongated columnar shape of wing disc cells and suggest that Dpp signaling acts by regulating Rho1 and MRLC...
  11. ncbi Dynamic behavior of the cadherin-based cell-cell adhesion system during Drosophila gastrulation
    H Oda
    Exploratory Research for Advanced Technology, Japan Science and Technology Corporation, Kyoto Research Park, Kyoto, Chudoji Minami machi, Shimogyo ku, 600 8813, Japan
    Dev Biol 203:435-50. 1998
    ..In the present study, we examined the dynamic aspects of cadherin-based cell-cell adhesion in the morphogenetic events to assess its contribution to morphogenesis...
  12. ncbi Real-time imaging of cell-cell adherens junctions reveals that Drosophila mesoderm invagination begins with two phases of apical constriction of cells
    H Oda
    Tsukita Cell Axis Project, Exploratory Research for Advanced Technology, Japan Science and Technology Corporation, Kyoto Research Park, Chudoji Minami machi, Shimogyo ku, Kyoto 600 8813, Japan
    J Cell Sci 114:493-501. 2001
    ..Movies available on-line: http://www.biologists.com/JCS/movies/jcs2073.html..
  13. pmc The exocyst component Sec5 is present on endocytic vesicles in the oocyte of Drosophila melanogaster
    Bernhard Sommer
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, England, UK
    J Cell Biol 169:953-63. 2005
    ..Thus, the exocyst may act in both Golgi to plasma membrane traffic and endocytic cycling, and hence in oocytes is recruited to clathrin-coated pits to facilitate the rapid recycling of Yolkless...
  14. pmc Zfh-1 controls somatic stem cell self-renewal in the Drosophila testis and nonautonomously influences germline stem cell self-renewal
    Judith L Leatherman
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Stem Cell 3:44-54. 2008
    ..In contrast, germline-intrinsic STAT activation was insufficient for GSC renewal. These data reveal unexpected complexity in cell interactions in the niche, implicating CPCs in GSC self-renewal...
  15. ncbi Multicellular rosette formation links planar cell polarity to tissue morphogenesis
    J Todd Blankenship
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Dev Cell 11:459-70. 2006
    ..We propose that the generation of higher-order rosette structures links local cell interactions to global tissue reorganization during morphogenesis...
  16. ncbi The Drosophila homolog of the Exo84 exocyst subunit promotes apical epithelial identity
    J Todd Blankenship
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    J Cell Sci 120:3099-110. 2007
    ..These results suggest that epithelial polarity in the Drosophila embryo is actively maintained by exocyst-dependent apical localization of the Crumbs transmembrane protein...
  17. ncbi Invasive cell behavior during Drosophila imaginal disc eversion is mediated by the JNK signaling cascade
    Jose Carlos Pastor-Pareja
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Cantoblanco, 28049 Madrid, Spain
    Dev Cell 7:387-99. 2004
    ..When eversion is completed, PS cells localize to the leading front, heading disc expansion. We found that the JNK pathway is necessary for PS/larval cells apposition, the PEMT, and the motile activity of leading front cells...
  18. ncbi Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila
    Yaopan Mao
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 133:2539-51. 2006
    ..Our results implicate Dachs as a crucial downstream component of a Fat signaling pathway that influences growth, affinity and gene expression during development...
  19. ncbi The serine/threonine kinase dPak is required for polarized assembly of F-actin bundles and apical-basal polarity in the Drosophila follicular epithelium
    Ryan Conder
    Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, Canada V5A 1S6
    Dev Biol 305:470-82. 2007
    ..We propose that dPak mediates communication between the basement membrane and intracellular proteins required for polarization of the basal F-actin and for apical-basal polarity...
  20. doi Increased cell bond tension governs cell sorting at the Drosophila anteroposterior compartment boundary
    Katharina P Landsberg
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Curr Biol 19:1950-5. 2009
    ..Our results provide a physical mechanism in which the local increase in Myosin II-dependent cell bond tension directs cell sorting at compartment boundaries...
  21. pmc aPKC phosphorylation of Bazooka defines the apical/lateral border in Drosophila epithelial cells
    Eurico Morais-de-Sá
    The Gurdon Institute and the Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Cell 141:509-23. 2010
    ..Although Baz acts as an aPKC targeting and specificity factor in nonepithelial cells, our results reveal that it performs a complementary function in positioning the adherens junction in epithelia...
  22. pmc Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection
    Nicolas Buchon
    Global Health Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    BMC Biol 8:152. 2010
    ..However, the precise cellular events that occur following infection have not been quantitatively described, nor do we understand the interaction between multiple pathways that have been implicated in epithelium renewal...
  23. ncbi Interaction of Par-6 and Crumbs complexes is essential for photoreceptor morphogenesis in Drosophila
    Sang Chul Nam
    Department of Molecular and Cellular Biology, Baylor College of Medicine, TX 77030, USA
    Development 130:4363-72. 2003
    ..These results suggest that the interaction of Crb and Par-6 complexes is required for the organization and maintenance of apical membranes and AJs of photoreceptors...
  24. ncbi Integrin-independent repression of cadherin transcription by talin during axis formation in Drosophila
    Isabelle E Bécam
    Institut Jacques Monod, CNRS, Universités Paris 6 et 7, 2, place Jussieu, F 75251 Paris Cedex 05, France
    Nat Cell Biol 7:510-6. 2005
    ..The invariant position of the oocyte is thought to be driven by an upregulation of the adhesion molecule DE-cadherin in the oocyte and the posterior somatic follicle cells, providing the first in vivo example of cell sorting that ..
  25. pmc Regulatory mechanisms required for DE-cadherin function in cell migration and other types of adhesion
    Anne Pacquelet
    European Molecular Biology Laboratory EMBL, 69117 Heidelberg, Germany
    J Cell Biol 170:803-12. 2005
    b>Cadherin-mediated adhesion can be regulated at many levels, as demonstrated by detailed analysis in cell lines. We have investigated the requirements for Drosophila melanogaster epithelial (DE) cadherin regulation in vivo. Investigating D...
  26. ncbi A Drosophila homolog of cadherin associated with armadillo and essential for embryonic cell-cell adhesion
    H Oda
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Dev Biol 165:716-26. 1994
    ..is a transmembrane protein with similarity to vertebrate classic cadherins, and so we designated this molecule DE-cadherin. The extracellular domain has six cadherin-specific repeats, although the first repeat seems to be cleaved off ..
  27. ncbi inscuteable, a neural precursor gene of Drosophila, encodes a candidate for a cytoskeleton adaptor protein
    R Kraut
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Cologne, Germany
    Dev Biol 174:65-81. 1996
    ..The inscuteable mutant phenotype, together with these other observations, suggests a possible role for the protein in cytoskeleton organization...
  28. ncbi The Drosophila AP axis is polarised by the cadherin-mediated positioning of the oocyte
    A González-Reyes
    The Wellcome CRC Institute and Department of Genetics, University of Cambridge, Cambridge CB2 1QR, UK
    Development 125:3635-44. 1998
    ..During this germ cell rearrangement, the components of the homophilic cadherin adhesion complex, DE-cadherin, Armadillo and alpha-catenin, accumulate along the border between the oocyte and ..
  29. pmc Distinct mechanisms regulate hemocyte chemotaxis during development and wound healing in Drosophila melanogaster
    Will Wood
    Instituto Gulbenkian de Ciencia, 2780 156 Oeiras, Portugal
    J Cell Biol 173:405-16. 2006
    ....
  30. ncbi Specialized extraembryonic cells connect embryonic and extraembryonic epidermis in response to Dpp during dorsal closure in Drosophila
    Atsushi Wada
    Laboratory for Morphogenetic Signaling, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
    Dev Biol 301:340-9. 2007
    ....
  31. pmc New components of the Drosophila fusome suggest it plays novel roles in signaling and transport
    Daniel V Lighthouse
    Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution, Baltimore, MD 21218, USA
    Dev Biol 317:59-71. 2008
    ..In contrast, rab11 is required to maintain the germline stem cells, and to maintain the vesicle content of the spectrosome, suggesting that the fusome mediates intercellular signals that depend on the recycling endosome...
  32. pmc The Hippo pathway regulates apical-domain size independently of its growth-control function
    Alice Genevet
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Cell Sci 122:2360-70. 2009
    ..Therefore, Hippo signalling controls growth and apical domain size by distinct mechanisms...
  33. doi Sec24-dependent secretion drives cell-autonomous expansion of tracheal tubes in Drosophila
    Dominique Förster
    Institute of Zoology, Universitat Zurich, CH 8057 Zurich, Switzerland
    Curr Biol 20:62-8. 2010
    ..These results indicate a critical role of membrane-associated proteins in the process and imply a mechanism that coordinates autonomous behaviors of individual cells within epithelial structures...
  34. pmc Abl regulates planar polarized junctional dynamics through β-catenin tyrosine phosphorylation
    Masako Tamada
    Howard Hughes Medical Institute and Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA
    Dev Cell 22:309-19. 2012
    ..These results demonstrate that the asymmetrically localized Abl tyrosine kinase directs planar polarized junctional remodeling during Drosophila axis elongation through the tyrosine phosphorylation of β-catenin...
  35. doi Membrane domain modulation by Spectrins in Drosophila photoreceptor morphogenesis
    Tony W Chen
    Department of Biology, Baylor University, Waco, Texas 76798, USA
    Genesis 47:744-50. 2009
    ..These results indicate that Spectrins are required for controlling photoreceptor morphogenesis through the modulations of cell membrane domains...
  36. ncbi The Drosophila genes crumbs and stardust are involved in the biogenesis of adherens junctions
    F Grawe
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Germany
    Development 122:951-9. 1996
    ..mutants, the defect observed at the ultrastructural level are preceded by a misdistribution of Armadillo and DE-cadherin, the homologues of beta-catenin and E-cadherin, respectively, which are two constituents of the vertebrate ..
  37. ncbi Cadherins in embryonic and neural morphogenesis
    U Tepass
    Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada
    Nat Rev Mol Cell Biol 1:91-100. 2000
    ..Cadherins may also contribute to neurite outgrowth and pathfinding, and to synaptic specificity and modulation in the central nervous system...
  38. ncbi The role of PAR-1 in regulating the polarised microtubule cytoskeleton in the Drosophila follicular epithelium
    Hélène Doerflinger
    The Wellcome Trust Cancer Research UK Institute and the Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Development 130:3965-75. 2003
    ..Although the direct targets of PAR-1 are unknown, we suggest that it functions by regulating the plus ends, possibly by capping them at the basal cortex...
  39. ncbi The Drosophila lymph gland as a developmental model of hematopoiesis
    Seung Hye Jung
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Development 132:2521-33. 2005
    ..The cellular events identified in this analysis further establish Drosophila as a model system for hematopoiesis...
  40. pmc Adherens junction remodeling by the Notch pathway in Drosophila melanogaster oogenesis
    Muriel Grammont
    Institut National de la Sante et de la Recherche Medicale, Unité 384, Clermont Ferrand F 63001, France
    J Cell Biol 177:139-50. 2007
    ..By monitoring the expression of epithelial cadherin and Armadillo, I have discovered that the rate of AJ disassembly between the StCs is affected in follicles ..
  41. pmc Physical modeling of cell geometric order in an epithelial tissue
    Sascha Hilgenfeldt
    Engineering Sciences and Applied Mathematics, Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 105:907-11. 2008
    ..We show that combining adhesive forces due to E- and N-cadherin with a quantitative description of cell membrane elasticity in an interfacial energy model explains not only the ..
  42. pmc The DHHC palmitoyltransferase approximated regulates Fat signaling and Dachs localization and activity
    Hitoshi Matakatsu
    Department of Zoology, University of Wisconsin, 250 North Mills Street, Madison, Wisconsin 53706, USA
    Curr Biol 18:1390-5. 2008
    ..We show that App encodes a member of the DHHC family, responsible for the palmitoylation of selected cytoplasmic proteins, and provide evidence that App acts by controlling the normal subcellular localization and activity of Dachs...
  43. pmc The apical/basal-polarity determinant Scribble cooperates with the PCP core factor Stbm/Vang and functions as one of its effectors
    Jean Remy Courbard
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, Annenberg Bldg 18 92, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Biol 333:67-77. 2009
    ..We define a scribble allele that is largely PCP specific. Our data show that Scribble is part of the Stbm/Vang PCP complex and further suggest that it might act as an effector of Stbm/Vang during PCP establishment...
  44. pmc JAK-STAT signal inhibition regulates competition in the Drosophila testis stem cell niche
    Melanie Issigonis
    Department of Cell Biology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Science 326:153-6. 2009
    ..Thus, in niches housing multiple stem cell types, negative feedback loops can modulate signaling, preventing one stem cell population from outcompeting the other...
  45. ncbi Requirements for adherens junction components in the interaction between epithelial tissues during dorsal closure in Drosophila
    Nicole Gorfinkiel
    Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, UK
    J Cell Sci 120:3289-98. 2007
    ..We also find that interactions between Armadillo and E-cadherin play an important role in maintaining the adhesion at the leading edge, revealing the particular dynamics of this ..
  46. ncbi Roles of Armadillo, a Drosophila catenin, during central nervous system development
    J Loureiro
    Department of Biology, University of North Carolina, Chapel Hill 27599 3280, USA
    Curr Biol 8:622-32. 1998
    ..Wingless/Wnt signaling also directs certain cell fates in the central nervous system (CNS), and cadherins and catenins are thought to function together during neural development...
  47. ncbi Cadherin superfamily proteins in Caenorhabditis elegans and Drosophila melanogaster
    E Hill
    MRC, Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    J Mol Biol 305:1011-24. 2001
    The ability to form selective cell-cell adhesions is an essential property of metazoan cells. Members of the cadherin superfamily are important regulators of this process in both vertebrates and invertebrates...
  48. ncbi Cellular processes associated with germ band retraction in Drosophila
    Frieder Schock
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Dev Biol 248:29-39. 2002
    ..The results establish the cellular movements and shape changes occurring during GBR and provide the basis for an analysis of the forces acting during GBR...
  49. ncbi The RhoGEF Pebble is required for cell shape changes during cell migration triggered by the Drosophila FGF receptor Heartless
    Sabine Schumacher
    Institut fur Genetik, Heinrich Heine Universitat, Dusseldorf, Germany
    Development 131:2631-40. 2004
    ..These results provide evidence for a novel function of the Rho-GEF PBL in HTL-dependent mesodermal cell migration...
  50. pmc Egfr/Ras signaling regulates DE-cadherin/Shotgun localization to control vein morphogenesis in the Drosophila wing
    David D O'Keefe
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Biol 311:25-39. 2007
    ..found that Ras signaling regulates both the levels and subcellular localization of the cell adhesion molecule DE-cadherin/Shotgun (Shg) in the differentiating wing epithelium...
  51. doi Membrane targeting of Bazooka/PAR-3 is mediated by direct binding to phosphoinositide lipids
    Michael P Krahn
    Abteilung Stammzellbiologie, DFG Research Center for Molecular Physiology of the Brain CMPB, Georg August Universitat Gottingen, Justus von Liebig Weg 11, Gottingen, Germany
    Curr Biol 20:636-42. 2010
    ..Our findings reveal a mechanism for the coupling of plasma membrane polarity and cortical polarity...
  52. ncbi The Drosophila PAR-1 spacer domain is required for lateral membrane association and for polarization of follicular epithelial cells
    Thomas Vaccari
    Developmental Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Curr Biol 15:255-61. 2005
    ..Our data indicate that the spacer domain of PAR-1 is required for lateral PM localization of PAR-1 kinase and for development of a polarized FE...
  53. ncbi Hexagonal packing of Drosophila wing epithelial cells by the planar cell polarity pathway
    Anne Kathrin Classen
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01309 Dresden, Germany
    Dev Cell 9:805-17. 2005
    ..During the process, individual cell boundaries grow and shrink, resulting in local neighbor exchanges, and Cadherin is actively endocytosed and recycled through Rab11 endosomes...
  54. pmc Cell adhesion and cortex contractility determine cell patterning in the Drosophila retina
    Jos Käfer
    Laboratoire de Spectrometrie Physique, Unite Mixte de Recherche 5588, Université Joseph Fourier Grenoble I and Centre National de la Recherche Scientifique, 140 Avenue de la Physique, 38402 Saint Martin d Heres, France
    Proc Natl Acad Sci U S A 104:18549-54. 2007
    ..flies, as well as in flies with different numbers of cells per ommatidia, and mutants with cells where E- or N-cadherin is either deleted or misexpressed...
  55. pmc Su(dx) E3 ubiquitin ligase-dependent and -independent functions of polychaetoid, the Drosophila ZO-1 homologue
    Alexandre Djiane
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, England, UK
    J Cell Biol 192:189-200. 2011
    ..As both Su(dx) and Expanded regulate trafficking, we propose that a conserved role of ZO proteins is to coordinate receptor trafficking and signaling with junctional organization...
  56. pmc Regulation of cyclin A localization downstream of Par-1 function is critical for the centrosome orientation checkpoint in Drosophila male germline stem cells
    Hebao Yuan
    Life Sciences Institute, Center for Stem Cell Biology, University of Michigan, Ann Arbor, MI 48109 2216, USA
    Dev Biol 361:57-67. 2012
    ..We propose that the regulation of cyclin A localization via Par-1 function plays a critical role in the centrosome orientation checkpoint...
  57. doi AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster
    Satoshi Kametaka
    Department of Anatomy and Histology, Fukushima Medical University, 1 Hikarigaoka, Fukushima, Fukushima 960 1295, Japan
    J Cell Sci 125:634-48. 2012
    ..These results suggest that AP-1 and Aftiphilin are cooperatively involved in the intracellular trafficking of Notch during eye development in Drosophila...
  58. ncbi Dynamic features of adherens junctions during Drosophila embryonic epithelial morphogenesis revealed by a Dalpha-catenin-GFP fusion protein
    H Oda
    Tsukita Cell Axis Project, Exploratory Research for Advanced Technology, Japan Science and Technology Corporation, Kyoto Research Park, Chudoji Minami machi, Shimogyo ku, Kyoto 600 8813, Japan
    Dev Genes Evol 209:218-25. 1999
    Cell-cell adherens junctions (AJs), comprised of the cadherin-catenin adhesion system, contribute to cell shape changes and cell movements in epithelial morphogenesis...
  59. ncbi Germline stem cells anchored by adherens junctions in the Drosophila ovary niches
    Xiaoqing Song
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Science 296:1855-7. 2002
    ..Here, we demonstrate that DE-cadherin-mediated cell adhesion is required for anchoring germline stem cells (GSCs) in their niches in the Drosophila ..
  60. ncbi Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled
    T Usui
    Department of Biophysics, Faculty of Science, Japan
    Cell 98:585-95. 1999
    We identified a seven-pass transmembrane receptor of the cadherin superfamily, designated Flamingo (Fmi), localized at cell-cell boundaries in the Drosophila wing. In the absence of Fmi, planar polarity was distorted...
  61. ncbi Nonchordate classic cadherins have a structurally and functionally unique domain that is absent from chordate classic cadherins
    H Oda
    Exploratory Research for Advanced Technology, Japan Science and Technology Corporation, Kyoto Research Park, Chudoji Minami machi, Shimogyo ku, Kyoto, 600 8813, Japan
    Dev Biol 216:406-22. 1999
    ..Although nonchordate classic cadherins have cadherin superfamily-specific extracellular repeats (CRs) and a highly conserved cytoplasmic domain (CP), these cadherins ..
  62. ncbi A germline-specific gap junction protein required for survival of differentiating early germ cells
    Salli I Tazuke
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
    Development 129:2529-39. 2002
    ....
  63. ncbi The Drosophila cytokine receptor Domeless controls border cell migration and epithelial polarization during oogenesis
    Christian Ghiglione
    Institute of Signaling, Developmental Biology and Cancer, UMR 6543 CNRS, Parc Valrose, 06108 Nice Cedex 2, France
    Development 129:5437-47. 2002
    ..Altogether, our data indicate that Dome is an essential receptor molecule for Upd and JAK/STAT signaling during oogenesis...
  64. pmc The positioning and segregation of apical cues during epithelial polarity establishment in Drosophila
    Tony J C Harris
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 170:813-23. 2005
    ..These results reveal key steps in the assembly of the apical domain in Drosophila...
  65. ncbi Spatial control of actin organization at adherens junctions by a synaptotagmin-like protein Btsz
    Fanny Pilot
    Institut de Biologie du Développement de Marseille Luminy IBDML UMR 6216, CNRS Université de la Méditerrannée Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Nature 442:580-4. 2006
    ..fundamental property relies on intercellular adhesion through the formation of adherens junctions containing E-cadherin molecules...
  66. ncbi shotgun encodes Drosophila E-cadherin and is preferentially required during cell rearrangement in the neurectoderm and other morphogenetically active epithelia
    U Tepass
    Department of Molecular Cellular Developmental Biology, University of California at Los Angeles, 90024 1606, USA
    Genes Dev 10:672-85. 1996
    Adhesion molecules of the cadherin superfamily have an important role during vertebrate development. The DE-cadherin homolog DE-cadherin is the first classic cadherin isolated from invertebrates...
  67. pmc Armadillo is required for adherens junction assembly, cell polarity, and morphogenesis during Drosophila embryogenesis
    R T Cox
    Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, 27599 3280, USA
    J Cell Biol 134:133-48. 1996
    ..These disruptions in the integrity of epithelia block the appropriate morphogenetic movements of gastrulation. These results provide the first demonstration of the effect of loss of adherens junctions on Drosophila embryonic development...
  68. pmc Apical, lateral, and basal polarization cues contribute to the development of the follicular epithelium during Drosophila oogenesis
    G Tanentzapf
    Department of Zoology, University of Toronto, Toronto, Ontario, Canada M5S 3G5
    J Cell Biol 151:891-904. 2000
    ..Finally, we show that the cadherin-catenin complex is not required for the formation of the follicular epithelium, but only for its maintenance...
  69. ncbi Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin
    B M McCartney
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3280, USA
    Nat Cell Biol 3:933-8. 2001
    ..Together, these data suggest that APC2, Armadillo and alpha-catenin provide an important link between spindles and cortical actin, and that this link is regulated by Zeste-white 3 kinase...
  70. ncbi Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts
    Y Hong
    Howard Hughes Medical Institute, Department of Physiology and Biochemistry, University of California San Francisco, San Francisco, California 94143 0725, USA
    Nature 414:634-8. 2001
    ..However, for the subset of ectodermal cells that delaminate and form neuroblasts, their polarity requires the function of Bazooka, but not of Stardust or Crumbs...
  71. ncbi Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity
    A Bachmann
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Germany
    Nature 414:638-43. 2001
    ..The Stardust proteins represent versatile candidates as structural and possibly regulatory constituents of the SAC, a crucial element in the control of epithelial cell polarity...
  72. ncbi Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila
    D L Silver
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Cell 107:831-41. 2001
    ..Ectopic expression of either UPD or JAK is sufficient to induce extra epithelial cells to migrate. Thus, a localized signal activates the JAK/STAT pathway in neighboring epithelial cells, causing them to become invasive...
  73. ncbi Eyes closed, a Drosophila p47 homolog, is essential for photoreceptor morphogenesis
    Tzu Kang Sang
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Development 129:143-54. 2002
    ..Loss of Eyc function results in a lethal failure of nuclear envelope assembly in early zygotic divisions. Phenotypes resulting from eyc mutations provide the first in vivo evidence for a role for p47 in membrane biogenesis...
  74. ncbi Establishing cell polarity in development
    Andreas Wodarz
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstr 1, 40225 Dusseldorf, Germany
    Nat Cell Biol 4:E39-44. 2002
    ..There is growing evidence that the proteins encoded by these genes interact with key regulators of both the actin and the microtubule cytoskeletons...
  75. ncbi Rap1 GTPase regulation of adherens junction positioning and cell adhesion
    Andrea L Knox
    Wellcome CRC Institute and Department of Anatomy, University of Cambridge, Cambridge CB2 1QR, UK
    Science 295:1285-8. 2002
    ..Rap1 is enriched at adherens junctions, particularly between newly divided sister cells where it may reseal the adherens junction ring. The regulation of adherens junction positioning could play a role in cell mobility and cell division...
  76. ncbi Interaction between EGFR signaling and DE-cadherin during nervous system morphogenesis
    Karin Dumstrei
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, 90095, USA
    Development 129:3983-94. 2002
    ..the visual system in Drosophila embryos as a model system to investigate the function of the Drosophila classic cadherin, DE-cadherin, which is encoded by the shotgun (shg) gene...
  77. ncbi Bazooka is a permissive factor for the invasive behavior of discs large tumor cells in Drosophila ovarian follicular epithelia
    Salim Abdelilah-Seyfried
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Robert Rossle Strasse 10, D 13125 Berlin Buch, Germany
    Development 130:1927-35. 2003
    ....
  78. ncbi Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome
    Yukiko M Yamashita
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
    Science 301:1547-50. 2003
    ....
  79. ncbi The exocyst component Sec5 is required for membrane traffic and polarity in the Drosophila ovary
    Mala Murthy
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Development 131:377-88. 2004
    ..However, we find the cytoskeleton to be correctly oriented. We conclude that Sec5 is required for directed membrane traffic, and consequently for the establishment of polarity within the developing oocyte...
  80. ncbi Junctions and vesicular trafficking during Drosophila cellularization
    Thomas Lecuit
    Laboratoire de Genetique et de Physiologie du Developpement, UMR 6545 CNRS Université de la Méditerranée, Institut de Biologie du Developpement de Marseille, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    J Cell Sci 117:3427-33. 2004
    ..The novel proteins Nullo and Slam, which are specifically induced during cellularization, represent developmental regulators of membrane growth during cellularization...
  81. pmc Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells
    Slobodan Beronja
    Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    J Cell Biol 169:635-46. 2005
    ..Furthermore, we show that Rab11 forms a complex with Sec5 and that Sec5 interacts with Sec6 suggesting that the exocyst is a Rab11 effector that facilitates protein transport to the apical rhabdomere in Drosophila PRCs...
  82. ncbi Influence of Notch on dorsoventral compartmentalization and actin organization in the Drosophila wing
    Robert J Major
    Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 132:3823-33. 2005
    ....
  83. ncbi Rho1 regulates Drosophila adherens junctions independently of p120ctn
    Donald T Fox
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Development 132:4819-31. 2005
    ..Loss of Rho1 results in ectopic accumulation of cytoplasmic DE-cadherin, but ectopic cadherin does not accumulate with its partner Armadillo...
  84. ncbi Endocytic control of epithelial polarity and proliferation in Drosophila
    Han Lu
    Department of Molecular and Cell Biology, University of California Berkeley, 142 LSA 3200 Berkeley, CA 94720 3200 USA
    Nat Cell Biol 7:1232-9. 2005
    ..Our findings reveal a critical and specific role for endocytic traffic in the control of both apico-basal polarity and cell proliferation...
  85. ncbi Par-1 kinase establishes cell polarity and functions in Notch signaling in the Drosophila embryo
    Jennifer Bayraktar
    Department of Biochemistry, Molecular Biology and Cell Biology, 2205 Tech Drive, Northwestern University, Evanston, IL 60208, USA
    J Cell Sci 119:711-21. 2006
    ..Epistasis analysis indicates that Par-1 functions upstream of Notch and is critical for proper localization of the Notch ligand Delta...
  86. pmc Novel roles for APC family members and Wingless/Wnt signaling during Drosophila brain development
    Melissa A Hayden
    Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Dev Biol 305:358-76. 2007
    ..Finally, we propose a model suggesting that Wg signaling regulates fine scale cell fates along the anterior-posterior axis, in part by creating an adhesion gradient and consider possible alternate explanations for our observations...
  87. pmc aPKC controls microtubule organization to balance adherens junction symmetry and planar polarity during development
    Tony J C Harris
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    Dev Cell 12:727-38. 2007
    ..aPKC apparently regulates this balance. Without aPKC, abnormally strong microtubule interactions break AJ symmetry and epithelial structure is lost...
  88. pmc Myosin V, Rab11, and dRip11 direct apical secretion and cellular morphogenesis in developing Drosophila photoreceptors
    Bingbing X Li
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    J Cell Biol 177:659-69. 2007
    ..A protein trio conserved across eukaryotes thus mediates normal, in vivo sensory neuron morphogenesis...
  89. pmc Cellular behavior in the developing Drosophila pupal retina
    David E Larson
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8103, Saint Louis, MO 63110, USA
    Mech Dev 125:223-32. 2008
    ..Based upon our live visualization of the P120-Catenin mutant as well as genetic data, we conclude that P120-Catenin is acting to stabilize E-cadherin and adherens junction integrity during eye development.
  90. pmc The Drosophila CD2AP/CIN85 orthologue Cindr regulates junctions and cytoskeleton dynamics during tissue patterning
    Ruth I Johnson
    Department of Developmental and Regenerative Biology, Mount Sinai Medical School, New York, NY 10029, USA
    J Cell Biol 180:1191-204. 2008
    ..Using D. melanogaster retina, we demonstrate that Cindr links cell surface junctions (E-cadherin) and adhesion (Roughest) with multiple components of the actin cytoskeleton...
  91. doi Control of cell flattening and junctional remodeling during squamous epithelial morphogenesis in Drosophila
    Karen L Pope
    Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, ON, M5S 3G5, Canada
    Development 135:2227-38. 2008
    ..Genetic analysis revealed that Myosin II and Bazooka cooperate to properly position adherens junctions. These results identify a specific cellular mechanism of squamous tissue morphogenesis and molecular interactions involved...
  92. doi Modulation of intracellular trafficking regulates cell intercalation in the Drosophila trachea
    Daniel D Shaye
    Institut de Biologia Molecular de Barcelona CSIC, C Baldiri Reixac 10, 08028 Barcelona, Spain
    Nat Cell Biol 10:964-70. 2008
    ..Finally, we provide evidence that levels of E-cadherin (DE-cad), an adherens junction component and Rab11-compartment cargo, are dynamically regulated by trafficking ..
  93. pmc Expression patterns of cadherin genes in Drosophila oogenesis
    Jeremiah J Zartman
    Lewis Sigler Institute, Department of Chemical Engineering, Princeton University, Princeton, NJ 08544, USA
    Gene Expr Patterns 9:31-6. 2009
    ..In late oogenesis, the expression patterns of cadherin genes in the main body follicle cells is summarized using a compact set of simple geometric shapes, reflecting ..
  94. pmc DE-Cadherin is required for intercellular motility during Drosophila oogenesis
    P Niewiadomska
    Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    J Cell Biol 144:533-47. 1999
    ..to pinpoint the precise function of cadherins in morphogenetic processes due to the multifunctional nature of cadherin requirement...
  95. ncbi A new Drosophila APC homologue associated with adhesive zones of epithelial cells
    X Yu
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Nat Cell Biol 1:144-51. 1999
    ..E-APC is concentrated in apicolateral adhesive zones of epithelial cells, along with Armadillo and E-cadherin, which are both integral components of the adherens junctions in these zones...
  96. ncbi Drosophila RhoA regulates the cytoskeleton and cell-cell adhesion in the developing epidermis
    James W Bloor
    Developmental, Cell and Molecular Biology Group, Department of Biology, B330 LSRC Building, Duke University, Durham, NC 27708 1000, USA
    Development 129:3173-83. 2002
    ..that defects in actin organization, nonmuscle myosin II localization, the regulation of gene transcription, DE-cadherin-based cell-cell adhesion and cell polarity underlie the effects of DRhoA(N19) expression...
  97. ncbi Moesin functions antagonistically to the Rho pathway to maintain epithelial integrity
    Olga Speck
    DCMB Group, Department of Biology, Duke University, Box 91000, Durham, North Carolina 27708, USA
    Nature 421:83-7. 2003
    ..Furthermore, our results show that there is negative feedback between ERM activation and activity of the Rho pathway...
  98. ncbi Armadillo levels are reduced during mitosis in Drosophila
    Steven J Marygold
    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Mech Dev 120:157-65. 2003
    ..We conclude that this phenomenon may reduce the efficacy of Wingless signalling and/or intercellular adhesion during cell division...
  99. ncbi Diversification of epithelial adherens junctions with independent reductive changes in cadherin form: identification of potential molecular synapomorphies among bilaterians
    Hiroki Oda
    JT Biohistory Research Hall, 1 1 Murasaki cho, Takatsuki, Osaka 569 1125, Japan
    Evol Dev 7:376-89. 2005
    ..In this study, we attempted to reconstruct the evolution of cadherin by analyzing new data from several arthropods (two insects, one non-insect hexapod, three crustaceans, and one ..
  100. ncbi Male and female Drosophila germline stem cells: two versions of immortality
    Margaret T Fuller
    Departments of Developmental Biology and Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 316:402-4. 2007
    ..Comparing these two stem cells and their niches in detail is likely to reveal how a common heritage has been adapted to the differing requirements of male and female gamete production...
  101. pmc DRhoGEF2 and diaphanous regulate contractile force during segmental groove morphogenesis in the Drosophila embryo
    Shai Mulinari
    Department of Experimental Medical Science, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, 22184 Lund, Sweden
    Mol Biol Cell 19:1883-92. 2008
    ..We propose that DRhoGEF2 acts through Rho1 to regulate acto-myosin constriction but not Diaphanous-mediated F-actin nucleation during segmental groove morphogenesis...

Research Grants8

  1. BETA H-SPECTRIN--ROLES IN CELL POLARITY AND SIGNALING
    Graham Thomas; Fiscal Year: 2001
    ..They will also illuminate the relationship between ras signaling and the cytoskeleton, a relationship that is important for oncogenic and metastatic processes. ..
  2. Wnt and beta-Catenin Signaling in Development/Disease
    Mariann Bienz; Fiscal Year: 2006
    ..Basic researchers and the pharmaceutical and biotechnology industry are invited to discuss how to exploit model systems and how to translate knowledge from these into drug development. [unreadable] [unreadable]..
  3. Analysis of fringe-dependent cell-signaling
    Kenneth Irvine; Fiscal Year: 2004
    ....
  4. Development of tissue-specific cell lines in Drosophila
    Amanda Simcox; Fiscal Year: 2009
    ..Subsequent use of the cell lines by individual investigators to study diverse biological problems is expected to impact our understanding of human disease. ..
  5. PHOTORECEPTOR CELL DEVELOPMENT AND SIGNAL TRANSDUCTION
    Richard Carthew; Fiscal Year: 2005
    ..abstract_text> ..
  6. Molecular Mechanisms of Drosophila Gonad Morphogenesis
    Mark Van Doren; Fiscal Year: 2005
    ..Interestingly, we have found that the cell adhesion molecule E-cadherin is also essential for gonad morphogenesis...
  7. Sexual Dimorphism in the Drosophila Gonad
    Mark Van Doren; Fiscal Year: 2008
    ..It will also provide a basis for understanding human syndromes, such as the one caused by loss of Sox9, where sexual dimorphism is disrupted, resulting in sex reversal and infertility. [unreadable] [unreadable]..