sev

Summary

Gene Symbol: sev
Description: sevenless
Alias: 7LES, 7less, CG18085, CT3980, DROSEV, DROSEV1, DmHD-265, Dmel\CG18085, HD-265, SEV, Sev, sev(AC)[[14]], CG18085 gene product from transcript CG18085-RA, CG18085-PA, sev-PA
Species: fruit fly

Top Publications

  1. ncbi Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation
    M E Fortini
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Nature 355:559-61. 1992
  2. ncbi Prepattern in the developing Drosophila eye revealed by an activated torso--sevenless chimeric receptor
    B Dickson
    Zoologisches Institut, Universitat Zurich, Switzerland
    Genes Dev 6:2327-39. 1992
  3. ncbi Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein
    Z C Lai
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Cell 70:609-20. 1992
  4. ncbi A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase
    U Gaul
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Cell 68:1007-19. 1992
  5. ncbi Signal transduction and the fate of the R7 photoreceptor in Drosophila
    G M Rubin
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Trends Genet 7:372-7. 1991
  6. ncbi Induction in the developing compound eye of Drosophila: multiple mechanisms restrict R7 induction to a single retinal precursor cell
    D L Van Vactor
    Howard Hughes Medical Institute, Department of Biological Chemistry, UCLA School of Medicine 90024 1737
    Cell 67:1145-55. 1991
  7. ncbi Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor
    H Kramer
    Department of Biological Chemistry, School of Medicine, University of California, Los Angeles 90024 1737
    Nature 352:207-12. 1991
  8. ncbi Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase
    M A Simon
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Cell 67:701-16. 1991
  9. ncbi Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye
    K Basler
    Zoologisches Institut, Universitat Zurich, Switzerland
    Cell 64:1069-81. 1991
  10. ncbi Glass encodes a site-specific DNA-binding protein that is regulated in response to positional signals in the developing Drosophila eye
    K Moses
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Genes Dev 5:583-93. 1991

Research Grants

  1. Genetic Architecture of Hsp90-buffered variation
    Suzannah Rutherford; Fiscal Year: 2009
  2. BETA H-SPECTRIN--ROLES IN CELL POLARITY AND SIGNALING
    Graham Thomas; Fiscal Year: 2001
  3. MOLECULAR SEQUENCE DATA
    Samuel Karlin; Fiscal Year: 2001
  4. Gene Expression Levels Across Diverse Genomes
    Samuel Karlin; Fiscal Year: 2006

Scientific Experts

Detail Information

Publications127 found, 100 shown here

  1. ncbi Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation
    M E Fortini
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Nature 355:559-61. 1992
    ..Mutations in three genes, sevenless (sev), bride-of-sevenless (boss) and seven-in-absentia (sina) cause the R7 precursor to become a non-neural cone cell...
  2. ncbi Prepattern in the developing Drosophila eye revealed by an activated torso--sevenless chimeric receptor
    B Dickson
    Zoologisches Institut, Universitat Zurich, Switzerland
    Genes Dev 6:2327-39. 1992
    ..Therefore, the expression of sevenless marks a preexisting pattern of developmental potential in the disc epithelium...
  3. ncbi Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein
    Z C Lai
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Cell 70:609-20. 1992
    ..Our data suggest that yan functions as a cell-autonomous negative regulator of photoreceptor development; in the presumptive R7 and cone cells, yan appears to act antagonistically to the proneural signal mediated by sevenless and Ras1...
  4. ncbi A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase
    U Gaul
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Cell 68:1007-19. 1992
    ..Our results suggest that Gap1 acts as a negative regulator of signaling by Sevenless by down-regulating the activity of the Ras1 protein, which has been shown to be a key element in signaling by Sevenless...
  5. ncbi Signal transduction and the fate of the R7 photoreceptor in Drosophila
    G M Rubin
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Trends Genet 7:372-7. 1991
    ..Studies of the mechanisms governing the specificity of signal transmission and reception suggest that the sevenless signal directs a bipotential cell towards a neuronal rather than a cone cell fate...
  6. ncbi Induction in the developing compound eye of Drosophila: multiple mechanisms restrict R7 induction to a single retinal precursor cell
    D L Van Vactor
    Howard Hughes Medical Institute, Department of Biological Chemistry, UCLA School of Medicine 90024 1737
    Cell 67:1145-55. 1991
    ..This process is mediated by bride of sevenless (boss), a cell-surface bound ligand, and the sevenless (sev) tyrosine kinase receptor...
  7. ncbi Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor
    H Kramer
    Department of Biological Chemistry, School of Medicine, University of California, Los Angeles 90024 1737
    Nature 352:207-12. 1991
    ..In the developing eye the sevenless-dependent internalization of bride of sevenless by the R7 precursor cell provides evidence for a direct interaction between these two proteins in vivo...
  8. ncbi Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase
    M A Simon
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Cell 67:701-16. 1991
    ..These results suggest that the stimulation of ras protein activity is a key element in the signaling by sevenless and Ellipse and that this stimulation may be achieved by activating the exchange of GTP for bound GDP by the ras protein...
  9. ncbi Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye
    K Basler
    Zoologisches Institut, Universitat Zurich, Switzerland
    Cell 64:1069-81. 1991
    ..These results illustrate the central role receptor tyrosine kinases can play in the specification of cell fate during development...
  10. ncbi Glass encodes a site-specific DNA-binding protein that is regulated in response to positional signals in the developing Drosophila eye
    K Moses
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Genes Dev 5:583-93. 1991
    ..This specificity may represent a regulation of glass protein activity after cells are recruited to the photoreceptor cell fate...
  11. ncbi Analysis of cis-acting requirements of the Rh3 and Rh4 genes reveals a bipartite organization to rhodopsin promoters in Drosophila melanogaster
    M E Fortini
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Genes Dev 4:444-63. 1990
    ....
  12. ncbi Ubiquitous expression of sevenless: position-dependent specification of cell fate
    K Basler
    Zoologisches Institut, Universitat Zurich, Switzerland
    Science 243:931-4. 1989
    ....
  13. pmc Regulation of the complex pattern of sevenless expression in the developing Drosophila eye
    D D Bowtell
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Proc Natl Acad Sci U S A 86:6245-9. 1989
    ..Thus the complex pattern of sevenless expression is redundantly encoded within proximal promoter sequences and enhancer elements internal to the gene but relies on these enhancer sequences for correct quantitative expression...
  14. pmc The spatial and temporal expression pattern of sevenless is exclusively controlled by gene-internal elements
    K Basler
    Zoologisches Institut, Universitat Zurich, Switzerland
    EMBO J 8:2381-6. 1989
    ..These gene-internal sequences function in both orientations on heterologous promoters, also when placed at the 3' end of a lacZ reporter gene...
  15. ncbi Sevenless, a cell-specific homeotic gene of Drosophila, encodes a putative transmembrane receptor with a tyrosine kinase domain
    E Hafen
    Science 236:55-63. 1987
    ....
  16. ncbi Molecular characterization and expression of sevenless, a gene involved in neuronal pattern formation in the Drosophila eye
    U Banerjee
    Cell 49:281-91. 1987
    ..We created P-element-induced alleles and used them to isolate the sev gene. An 8...
  17. ncbi Ommatidia in the developing Drosophila eye require and can respond to sevenless for only a restricted period
    D D Bowtell
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Cell 56:931-6. 1989
    ....
  18. ncbi Isolation of Drosophila melanogaster mutants with a wavelength-specific alteration in their phototactic response
    F Gerresheim
    Behav Genet 18:227-46. 1988
  19. ncbi Fine cytogenetical analysis of the band 10A1-2 and the adjoining regions in the Drosophila melanogaster X chromosome. II. Genetical analysis
    I F Zhimulev
    Chromosoma 82:25-40. 1981
    ..distal edge of the band; (ii) and (iii) two genes: v and 1(1)BP4; (iv) silent DNA in middle of the band, (v) locus sev on the proximal edge of the band. About 70% of the band's DNA was found to be silent...
  20. ncbi Control of Drosophila photoreceptor cell fates by phyllopod, a novel nuclear protein acting downstream of the Raf kinase
    B J Dickson
    Zoologisches Institut, Universitat Zurich, Switzerland
    Cell 80:453-62. 1995
    ..phyl thus represents a possible target gene of the Raf pathway during eye development, controlling the fates of a novel subset of photoreceptors...
  21. ncbi phyllopod functions in the fate determination of a subset of photoreceptors in Drosophila
    H C Chang
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley 94720 3200
    Cell 80:463-72. 1995
    ..phyl is also required for embryonic nervous system and sensory bristle development...
  22. pmc Molecular and cytogenetical characterization of the 10A1-2 band and adjoining region in the Drosophila melanogaster polytene X chromosome
    T u Kozlova
    Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138
    Genetics 136:1063-73. 1994
    ..In contrast, the 10A1-2 band contains three genes and at least six transcribed DNA fragments. (3) Comparison of genetic and physical maps shows that in this region 0.01 centiMorgan corresponds to 3.3 kb of DNA...
  23. ncbi Ras1 signaling and transcriptional competence in the R7 cell of Drosophila
    R C Kauffmann
    Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260, USA
    Genes Dev 10:2167-78. 1996
    ..Our results suggest that specific transcriptional responses are linked to the mode of activation of the Ras1/MAP kinase signal transduction pathway...
  24. ncbi Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye
    M Freeman
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 87:651-60. 1996
    ..These results broaden our view of eye development to include the whole ommatidium and suggest that reiterative activation of DER is critical for triggering the differentiation of all cell types...
  25. ncbi Identification of a novel Drosophila opsin reveals specific patterning of the R7 and R8 photoreceptor cells
    W H Chou
    Institute of Biotechnology, University of Texas Health Science Center, San Antonio 78245
    Neuron 17:1101-15. 1996
    ....
  26. pmc Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development
    H Meisner
    Program in Molecular Medicine, University of Massachusetts Medical Center, Worcester 01605, USA
    Mol Cell Biol 17:2217-25. 1997
    ....
  27. ncbi A new rhodopsin in R8 photoreceptors of Drosophila: evidence for coordinate expression with Rh3 in R7 cells
    D Papatsenko
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Development 124:1665-73. 1997
    ..Consistent with this, rh5 expression in R8 disappears when R7 cells are absent (in sevenless mutant). We propose a model for the concerted evolution of opsin genes and the elaboration of the architecture of the retina...
  28. ncbi Specification of primary pigment cell and outer photoreceptor fates by BarH1 homeobox gene in the developing Drosophila eye
    T Hayashi
    Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Dev Biol 200:131-45. 1998
    ..Here, we show evidence that BarH1 ectopically expressed under the control of the sevenless enhancer (sev-BarH1) causes two types of cone cell transformation: transformation of anterior/posterior cone cells into outer ..
  29. ncbi Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation
    J P Kumar
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322 3030, USA
    Development 125:3875-85. 1998
    ..Similarly, SEVENLESS-dependent activation results in cytoplasmic appearance of dp-ERK for 6 hours. These results suggest an additional regulated step in this pathway and we discuss models for this...
  30. ncbi Patterning of the R7 and R8 photoreceptor cells of Drosophila: evidence for induced and default cell-fate specification
    W H Chou
    Institute of Biotechnology and Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245 3207, USA
    Development 126:607-16. 1999
    ....
  31. ncbi Extraretinal photoreceptors at the compound eye's posterior margin in Drosophila melanogaster
    K Yasuyama
    Department of Biology, Kawasaki Medical School, Kurashiki City, Okayama 701 0192, Japan
    J Comp Neurol 412:193-202. 1999
    ..The pathway of eyelet's axon bundle coincides with the precocious pathway of Bolwig's nerve that arises from the larval organ of sight. The origin and possible function of eyelet are discussed...
  32. ncbi A Drosophila analogue of v-Cbl is a dominant-negative oncoprotein in vivo
    H Robertson
    Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, Melbourne, Vic, Australia
    Oncogene 19:3299-308. 2000
    ....
  33. ncbi Receptor tyrosine kinases: specific outcomes from general signals
    M A Simon
    Department of Biological Sciences, Stanford University, California 94305, USA
    Cell 103:13-5. 2000
  34. ncbi Overlapping activators and repressors delimit transcriptional response to receptor tyrosine kinase signals in the Drosophila eye
    C Xu
    Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260, USA
    Cell 103:87-97. 2000
    ..We show that Sevenless activates prospero independent of the enhancer and involves targeted degradation of Tramtrack, a transcription repressor...
  35. ncbi MASK, a large ankyrin repeat and KH domain-containing protein involved in Drosophila receptor tyrosine kinase signaling
    Rachel K Smith
    Department of Biological Sciences, Stanford University, 385 Serra Mall, Stanford, CA 94305 5020, USA
    Development 129:71-82. 2002
    The receptor tyrosine kinases Sevenless (SEV) and the Epidermal growth factor receptor (EGFR) are required for the proper development of the Drosophila eye...
  36. ncbi Cell diversity in the retina: more than meets the eye
    Tiffany Cook
    New York University, New York NY 10003, USA
    Bioessays 25:921-5. 2003
    ..As Prospero, the Drosophila homolog of Prox1, also participates in retinal cell specification, these data provide a forum for asking new questions concerning pathways that may regulate retinogenesis across evolution...
  37. ncbi The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors
    Tamara Mikeladze-Dvali
    Department of Biology, Center for Developmental Genetics, New York University, New York, New York 10003, USA
    Cell 122:775-87. 2005
    ..This represents an unexpected postmitotic role for genes controlling cell proliferation (warts and its partner hippo and salvador) and cell growth (melted)...
  38. pmc Stochastic spineless expression creates the retinal mosaic for colour vision
    Mathias F Wernet
    Center for Developmental Genetics, Department of Biology, New York University, 100 Washington Place, New York, New York 10003, USA
    Nature 440:174-80. 2006
    ..Therefore, this study suggests that the entire retinal mosaic required for colour vision is defined by the stochastic expression of a single transcription factor, Spineless...
  39. pmc Lola regulates cell fate by antagonizing Notch induction in the Drosophila eye
    Limin Zheng
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA
    Mech Dev 125:18-29. 2008
    ..The predicted consequence of this mechanism is to sharpen a cell's responsiveness to Notch signaling by creating a threshold...
  40. pmc Motion vision is independent of color in Drosophila
    Satoko Yamaguchi
    Department of Genetics and Neurobiology, Biozentrum, University of Wurzburg, 97074 Wurzburg, Germany
    Proc Natl Acad Sci U S A 105:4910-5. 2008
    ..We conclude that the color channel (R7/R8) does not contribute to motion detection as monitored by the optomotor response...
  41. pmc Coordinate control of synaptic-layer specificity and rhodopsins in photoreceptor neurons
    Marta Morey
    Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    Nature 456:795-9. 2008
    ....
  42. doi SOCS36E specifically interferes with Sevenless signaling during Drosophila eye development
    Isabel Almudi
    Departament de Genetica, Facultat de Biologia and Institut de Biomedicina IBUB, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Dev Biol 326:212-23. 2009
    ..We have used the specification of the R7 photoreceptor cells controlled by the Sevenless receptor tyrosine kinase (Sev) pathway to screen for modulators of pathway activity and to uncover the mechanisms underlying the robustness of ..
  43. pmc The HLH protein Extramacrochaetae is required for R7 cell and cone cell fates in the Drosophila eye
    Abhishek Bhattacharya
    Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Dev Biol 327:288-300. 2009
    ..A model is proposed in which Extramacrochaetae acts in parallel to or as a feed-forward regulator of the E(spl)-Complex to promote Notch signaling in particular cellular contexts...
  44. doi Determination of cell fates in the R7 equivalence group of the Drosophila eye by the concerted regulation of D-Pax2 and TTK88
    Yandong Shi
    Institute for Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Dev Biol 331:68-77. 2009
    ..Thus, the fates of R1/R6/R7 and cone cells are determined by a dual mechanism that coordinately activates one fate while inhibiting the other...
  45. pmc Contribution of photoreceptor subtypes to spectral wavelength preference in Drosophila
    Satoko Yamaguchi
    Center for Developmental Genetics, Department of Biology, New York University, New York, NY 10003, USA
    Proc Natl Acad Sci U S A 107:5634-9. 2010
    ..Involvement of all photoreceptors [R1-R6, R7, R8 (blue), R8 (green)] distinguishes phototaxis from motion detection that is mediated exclusively by R1-R6...
  46. ncbi Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases
    R D Rogge
    Department of Biology, University of California, Los Angeles 90024
    Cell 64:39-48. 1991
    ..We propose a model suggesting that the Sos product is downstream of sevenless and the EGF receptor, and that the dominant suppression results from the overexpression or increased activity of the gene product...
  47. ncbi Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila
    A Tomlinson
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Cell 51:143-50. 1987
    ..The protein is mostly localized at the apices of the cells, in microvilli, but is also found deeper in the tissue where certain cells contact the R8 cell. This finding suggests that R8 expresses a ligand for the sevenless protein...
  48. ncbi Sprouty, an intracellular inhibitor of Ras signaling
    T Casci
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 96:655-65. 1999
    ..Sprouty binds to two intracellular components of the Ras pathway, Drk and Gap1. Our results indicate that Sprouty is a widespread inhibitor of Ras pathway signal transduction...
  49. ncbi Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila
    S Kramer
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Development 126:2515-25. 1999
    ..These receptor tyrosine kinase-mediated pathways may share not only intracellular signaling components but also extracellular factors that modulate the strength of the signal...
  50. ncbi The role of cell-cell interaction in the development of the Drosophila visual system
    U Banerjee
    Department of Biology, University of California, Los Angeles 90024
    Neuron 4:177-87. 1990
  51. ncbi Signal transduction during the development of the Drosophila R7 photoreceptor
    M A Simon
    Department of Biological Sciences, Stanford University, California 94305 5020
    Dev Biol 166:431-42. 1994
  52. ncbi A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways
    D Brunner
    Zoologisches Institut, Universitat Zurich, Switzerland
    Cell 76:875-88. 1994
    In the Drosophila eye, activation of the sevenless (sev) receptor tyrosine kinase is required for the specification of the R7 photoreceptor cell fate...
  53. pmc Loss of tramtrack gene activity results in ectopic R7 cell formation, even in a sina mutant background
    Z C Lai
    Howard Hughes Medical Institute, University of California, Berkeley, 94720 3200, USA
    Proc Natl Acad Sci U S A 93:5025-30. 1996
    ..In particular, TTK activity appears to be autonomously required to regulate a sina-independent mechanism of R7 determination...
  54. ncbi The Drosophila secreted protein Argos regulates signal transduction in the Ras/MAPK pathway
    K Sawamoto
    Department of Molecular Neurobiology, University of Tsukuba, Ibaraki, Japan
    Dev Biol 178:13-22. 1996
    ..A phenotype of the sev; argos double mutants revealed that sev is epistatic to argos...
  55. pmc The Rap1 GTPase functions as a regulator of morphogenesis in vivo
    H Asha
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    EMBO J 18:605-15. 1999
    ..Rap1 mutations also disrupt cell migrations and cause abnormalities in cell shape. These findings indicate a role for Rap proteins as regulators of morphogenesis in vivo...
  56. ncbi The Drosophila SHC adaptor protein is required for signaling by a subset of receptor tyrosine kinases
    S Luschnig
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Mol Cell 5:231-41. 2000
    ..We show by double-mutant analysis that the adaptors DOS, DRK, and DSHC act in parallel to transduce the Torso signal. Our results suggest that DSHC confers specificity to receptor signaling...
  57. doi Modeling polarity buildup and cell fate decision in the fly eye: insight into the connection between the PCP and Notch pathways
    Jean François Le Garrec
    Modélisation dynamique des systèmes intégrés, Universite Pierre et Marie Curie Paris 6, 75005, Paris, France
    Dev Genes Evol 218:413-26. 2008
    ..The model provides insight into the crosstalk between the PCP and Notch modules in development and illustrates the ability of signaling modules to robustly maintain vital phenotypes in a noisy environment...
  58. pmc Dynamic control of cell cycle and growth coupling by ecdysone, EGFR, and PI3K signaling in Drosophila histoblasts
    Nikolay Ninov
    Instituto de Biologia Molecular de Barcelona, Consejo Superior de Investigaciones Cientificas, Barcelona, Spain
    PLoS Biol 7:e1000079. 2009
    ..It sets the stage for the comprehensive understanding of the coordination of cell growth and cell-cycle progression in complex multicellular eukaryotes...
  59. pmc Feedback from rhodopsin controls rhodopsin exclusion in Drosophila photoreceptors
    Daniel Vasiliauskas
    Center for Developmental Genetics, Department of Biology, New York University, New York, New York 10003, USA
    Nature 479:108-12. 2011
    ..Our observations reveal a thus far unappreciated spectral plasticity of R8 photoreceptors, and identify rhodopsin feedback as an exclusion mechanism...
  60. pmc Notch and Egfr signaling act antagonistically to regulate germ-line stem cell niche formation in Drosophila male embryonic gonads
    Yu Kitadate
    Okazaki Institute for Integrative Bioscience, Higashiyama, Myodaiji, Okazaki 444 8787, Japan
    Proc Natl Acad Sci U S A 107:14241-6. 2010
    ..Thus, we propose that SGPs sense PGC number via signals from PGCs to SGPs that modulate niche size, and that this serves as a mechanism for securing GSCs...
  61. ncbi The bride of sevenless and sevenless interaction: internalization of a transmembrane ligand
    R L Cagan
    Howard Hughes Medical Institute, Department of Biological Chemistry, University of California, Los Angeles 90024 1570
    Cell 69:393-9. 1992
    ..bride of sevenless (boss) on the surface of the R8 cell, which binds the sevenless tyrosine kinase receptor (sev) on the surface of the R7 precursor cell...
  62. ncbi Induction of the R7 neuron in the Drosophila compound eye: the bride of sevenless and sevenless interaction
    S L Zipursky
    Howard Hughes Medical Institute, Department of Biological Chemistry, Molecular Biology Institute, University of California, Los Angeles 90024
    Cold Spring Harb Symp Quant Biol 57:381-9. 1992
  63. pmc Neuronal development in the Drosophila retina: the sextra gene defines an inhibitory component in the developmental pathway of R7 photoreceptor cells
    R Rogge
    Department of Biology, University of California, Los Angeles 90024
    Proc Natl Acad Sci U S A 89:5271-5. 1992
    ..Additionally, sxt functions in R7 precursors, but the sevenless signal is essential for specification of this fate, since loss of sextra alone is unable to impart a neural fate to this cell...
  64. ncbi Histamine-like immunoreactivity in the visual system and brain of Drosophila melanogaster
    I Pollack
    Institut für Genetik und Mikrobiologie der Universität, Wurzburg, Federal Republic of Germany
    Cell Tissue Res 266:391-8. 1991
    ..In addition to the photoreceptors, fibres in the antennal nerve and approximately 12 neurons in each brain hemisphere show strong histamine-like immunoreactivity. These cells arborize extensively in large parts of the central brain...
  65. ncbi Specification of cell fate in the developing eye of Drosophila
    K Basler
    Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, N Y 10032
    Bioessays 13:621-31. 1991
    ..Genetic dissection of this pathway should therefore identify components of a signalling cascade activated by a tyrosine kinase...
  66. ncbi Receptor tyrosine kinases: genetic evidence for their role in Drosophila and mouse development
    T Pawson
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Trends Genet 6:350-6. 1990
    ....
  67. ncbi Reprogramming cell fate in the developing Drosophila retina: transformation of R7 cells by ectopic expression of rough
    K Basler
    Zoologisches Institut, Universitat Zurich, Switzerland
    Genes Dev 4:728-39. 1990
    ..We propose that in wild type, rough functions autonomously in the specification of R2/5 photoreceptor cell identity but by itself cannot initiate neural development...
  68. ncbi Photoreceptor-specific efficiencies of beta-carotene, zeaxanthin and lutein for photopigment formation deduced from receptor mutant Drosophila melanogaster
    W S Stark
    Division of Biological Sciences, University of Missouri, Columbia 65211
    J Comp Physiol A 166:429-36. 1990
    ..R8: R1-6 dominates w's electroretinogram; R7/8 generates w;ora's (ora = outer rhabdomeres absent); R8 generates w sev;- ora's (sev = sevenless). Microspectrophotometry revealed R1-6's visual pigment...
  69. ncbi Effect on eye development of dominant mutations in Drosophila homologue of the EGF receptor
    N E Baker
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Nature 340:150-3. 1989
    ....
  70. pmc Activated Drosophila Ras1 is selectively suppressed by isoprenyl transferase inhibitors
    R C Kauffmann
    Department of Biological Sciences, University of Pittsburgh, PA 15260, USA
    Proc Natl Acad Sci U S A 92:10919-23. 1995
    ..Therefore, FTI-254 acts as an isoprenylation inhibitor to selectively inhibit Ras1val12 signaling activity in a whole-animal model system...
  71. ncbi Circadian rhythms in Drosophila can be driven by period expression in a restricted group of central brain cells
    L B Vosshall
    Laboratory of Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
    Neuron 15:345-60. 1995
    ..When we genetically removed all external photoreceptor cells, rhythms persisted in these transgenic animals. This suggests that a few central brain cells producing glass and per are capable of generating biological rhythms...
  72. ncbi In vivo functional analysis of the Ras exchange factor son of sevenless
    C A Karlovich
    Department of Biology and Molecular Biology Institute, University of California, Los Angeles 90024, USA
    Science 268:576-9. 1995
    ..A possible role for Drk as an activator of Sos is discussed and a Drk-independent interaction between Sos and Sevenless is proposed that is likely mediated by the pleckstrin homology domain within the amino terminus...
  73. ncbi Nuclear factors in sevenless signalling
    B Dickson
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Trends Genet 11:106-11. 1995
    ....
  74. ncbi Genetic mosaic analysis of the equatorial-less mutation in Drosophila melanogaster
    K J Fryxell
    Department of Biology, University of California, Riverside 92521, USA
    Dev Genet 16:264-72. 1995
    ..The eql gene is located on the right arm of chromosome 2 at map location 2-104.5 +/- 0.7 and lies between the polytene chromosome bands 59D8 and 60A7...
  75. ncbi Focusing on the eyeless gene
    M Barinaga
    Science 267:1766-7. 1995
  76. ncbi Characterization of Star and its interactions with sevenless and EGF receptor during photoreceptor cell development in Drosophila
    A L Kolodkin
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Development 120:1731-45. 1994
    ..Based on the genetic interactions with Sos, we suggest that Star also has a later role in photoreceptor development including the recruitment of the R7 cell through the sevenless pathway...
  77. ncbi Signaling mechanisms in induction of the R7 photoreceptor in the developing Drosophila retina
    D Yamamoto
    Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    Bioessays 16:237-44. 1994
    ..However, recent studies indicate that Sevenless (Sev) functions just to neuralize the cell and has no role in R7 fate determination per se...
  78. ncbi Elucidation of the role of breathless, a Drosophila FGF receptor homolog, in tracheal cell migration
    M Reichman-Fried
    Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel
    Genes Dev 8:428-39. 1994
    ....
  79. ncbi Defining a neural 'ground state' and photoreceptor cell identifies in the Drosophila eye
    R W Warren
    Howard Hughes Medical Institute, Bock Laboratories, University of Wisconsin Madison 53706
    Bioessays 15:827-9. 1993
  80. ncbi Apical junctions and cell signalling in epithelia
    D F Woods
    Developmental Biology Center, University of California, Irvine 92717
    J Cell Sci Suppl 17:171-81. 1993
    ..The migration of the nucleus to the apical surface of the epithelium for mitosis may enable it to interact directly with the junction-associated signalling mechanisms...
  81. pmc Compositional heterogeneity and patterns of molecular evolution in the Drosophila genome
    J P Carulli
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110
    Genetics 134:837-45. 1993
    ....
  82. ncbi Ras1-dependent signaling by ectopically-expressed Drosophila src gene product in the embryo and developing eye
    S J Kussick
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Oncogene 8:2791-803. 1993
    ..These results suggest that over-expressed Dsrc may function through Ras1 to stimulate differentiation in the embryonic nervous system and eye imaginal disc, and that kinase-active Dsrc interferes with these processes...
  83. pmc The interaction of bride of sevenless with sevenless is conserved between Drosophila virilis and Drosophila melanogaster
    A C Hart
    Howard Hughes Medical Institute, University of California, Los Angeles 90024
    Proc Natl Acad Sci U S A 90:5047-51. 1993
    An inductive interaction between the sevenless (sev) transmembrane tyrosine kinase receptor and the bride of sevenless (boss) transmembrane ligand is required for the development of the R7 photoreceptor neuron in the compound eye of ..
  84. ncbi End of the line? Tramtrack and cell fate determination in Drosophila
    P Badenhorst
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Genes Cells 1:707-16. 1996
    ....
  85. ncbi Molecular cloning of Drosophila Rh6 rhodopsin: the visual pigment of a subset of R8 photoreceptor cells
    A Huber
    Universitat Karlsruhe, Institut für Zoologie I, Germany
    FEBS Lett 406:6-10. 1997
    ..Since R8 cells are founder cells in the developing compound eye, the isolation of a rhodopsin gene expressed in these cells may aid the understanding of terminal differentiation of photoreceptor cells...
  86. pmc The heat shock protein 83 (Hsp83) is required for Raf-mediated signalling in Drosophila
    A van der Straten
    Zoologisches Institut, Universitat Zurich, Switzerland
    EMBO J 16:1961-9. 1997
    ..Our results indicate that Hsp83 is essential for Raf function in vivo...
  87. ncbi Drosophila development: a receptor for ommatidial recruitment
    C Klämbt
    Institut fur Entwicklungsbiologie, Universitat zu Koln, 50923 Koln, Germany
    Curr Biol 7:R132-5. 1997
    ..Recent work shows that the differentiation of all the cell types found in the compound eye of Drosophila melanogaster is induced by reiterative activation of the EGF receptor...
  88. ncbi Intermittent divergence of the protein tyrosine kinase family during animal evolution
    H Suga
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    FEBS Lett 412:540-6. 1997
    ..These results strongly suggest that the PTKs diverged intermittently, but not gradually, during animal evolution...
  89. ncbi Molecular organization of an individual Drosophila polytene chromomere: transcribed sequences in the 10A1-2 band
    T Kozlova
    Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russian Federation
    Mol Gen Genet 257:55-61. 1997
    ..One of the transcriptionally active zones detected encompasses a previously unsuspected homologue of the genes Delta and Serrate...
  90. ncbi Naturally occurring genetic variation affects Drosophila photoreceptor determination
    P J Polaczyk
    Department of Biology, University of Michigan, Natural Science Building, Ann Arbor, MI 48109 1048, USA
    Dev Genes Evol 207:462-70. 1998
    ..This implies that different genes and/or alleles modify the two activated receptor genotypes. The evolutionary significance of the existence of high levels of genetic variation in the absence of normal phenotypic variation is discussed...
  91. ncbi Nuclear access and action of notch in vivo
    G Struhl
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cell 93:649-60. 1998
    ....
  92. pmc Disabled is a putative adaptor protein that functions during signaling by the sevenless receptor tyrosine kinase
    N Le
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    Mol Cell Biol 18:4844-54. 1998
    ..of the SH2-SH3 domain adaptor protein Grb2, is required during signaling by the sevenless receptor tyrosine kinase (SEV). One role of DRK is to provide a link between activated SEV and the Ras1 activator SOS...
  93. ncbi Sampling the genomic pool of protein tyrosine kinase genes using the polymerase chain reaction with genomic DNA
    A C Oates
    Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Royal Melbourne Hospital, Victoria, Australia
    Biochem Biophys Res Commun 249:660-7. 1998
    ..Furthermore, as a tool to hasten the discovery of members of gene families that are of particular interest, this method offers an opportunity to sample the genome for new members irrespective of their expression pattern...
  94. pmc Control of growth and differentiation by Drosophila RasGAP, a homolog of p120 Ras-GTPase-activating protein
    P Feldmann
    Cancer Research Campaign Center for Cell and Molecular Biology, The Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, United Kingdom
    Mol Cell Biol 19:1928-37. 1999
    ..Genetic interactions, however, suggested a Ras-independent role for RasGAP in the regulation of growth. The system described here should enable genetic screens to be performed to identify regulators and effectors of p120 Ras-GAP...
  95. pmc ebi regulates epidermal growth factor receptor signaling pathways in Drosophila
    X Dong
    Department of Biological Chemistry, Molecular Biology Institute, The School of Medicine, University of California, Los Angeles, California 90095 USA
    Genes Dev 13:954-65. 1999
    ..Proteins with related structures regulate protein degradation. Similarly, in the developing eye, ebi promotes EGFR-dependent down-regulation of Tramtrack88, an antagonist of neuronal development...
  96. ncbi Cell migration in Drosophila
    A Forbes
    Developmental Genetics Program, Skirball Institute and Howard Hughes Medical Institute, Department of Cell Biology, New York University Medical School, 540 First Ave, New York, New York 10016, USA
    Curr Opin Genet Dev 9:473-8. 1999
    ..In the female germline, the migratory path of border cells is directed by the homophilic adhesion molecule E cadherin...
  97. ncbi Shp-2 tyrosine phosphatase: signaling one cell or many
    G S Feng
    Department of Biochemistry, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana, 46202 5254, USA
    Exp Cell Res 253:47-54. 1999
    ..Shp-2 is an important molecule that integrates signals among various cytoplasmic pathways and may also couple intracellular and intercellular information flow...
  98. pmc Recruitment of the protein tyrosine phosphatase CSW by DOS is an essential step during signaling by the sevenless receptor tyrosine kinase
    R Herbst
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    EMBO J 18:6950-61. 1999
    ..protein Daughter of Sevenless (DOS) is an essential component of the Sevenless receptor tyrosine kinase (SEV) signaling cascade, which specifies R7 photoreceptor development in the Drosophila eye...
  99. ncbi Rasputin, the Drosophila homologue of the RasGAP SH3 binding protein, functions in ras- and Rho-mediated signaling
    C Pazman
    LMG, NICHD, NIH, MSC 2785, Bethesda, MD 20892, USA
    Development 127:1715-25. 2000
    ..These data suggest that Rin is not a general component of polarity generation, but serves a function specific to Ras and RhoA signaling pathways...
  100. ncbi Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins
    G Struhl
    Department of Genetics and Development, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Mol Cell 6:625-36. 2000
    ..Hence, Notch, beta-APP, and perhaps other proteins may be targeted for Presenilin-mediated transmembrane cleavage by upstream processing events that sever the extracellular domain from the rest of the protein...
  101. pmc Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites
    L Ciapponi
    European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Genes Dev 15:1540-53. 2001
    ..These results indicate that the distinction between ERK and JNK signals can be made at the level of D-Fos, and that different pathway-specific phosphorylated forms of the protein can elicit different responses...

Research Grants4

  1. Genetic Architecture of Hsp90-buffered variation
    Suzannah Rutherford; Fiscal Year: 2009
    ..We expect this research will identify conserved Hsp90 target pathways and an extended network of naturally polymorphic genes that influence their function. ..
  2. BETA H-SPECTRIN--ROLES IN CELL POLARITY AND SIGNALING
    Graham Thomas; Fiscal Year: 2001
    ..They will also illuminate the relationship between ras signaling and the cytoskeleton, a relationship that is important for oncogenic and metastatic processes. ..
  3. MOLECULAR SEQUENCE DATA
    Samuel Karlin; Fiscal Year: 2001
    ..by spacings between repeats, and by properties of repeat families (intergenic, coding, direct, inverted, mixed). ..
  4. Gene Expression Levels Across Diverse Genomes
    Samuel Karlin; Fiscal Year: 2006
    ..A third major objective of our research will be to extend our codon usage methods for predicting gene expression levels to eukaryotic genomes, including yeast, D. melanogaster, C. elegans, and human. [unreadable] [unreadable]..