Genomes and Genes
Gene Symbol: Sec6
Description: Secretory 6
Alias: CG5341, Dmel\CG5341, Dsec6, Sec6p, dsec6, sec 6, sec6, CG5341 gene product from transcript CG5341-RA, CG5341-PA, Sec6 ortholog, Sec6-PA, sec6, secretory 6
Species: fruit fly
- Sec6 mutations and the Drosophila exocyst complexMala Murthy
Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Cell Sci 118:1139-50. 2005To allow a detailed analysis of exocyst function in multicellular organisms, we have generated sec6 mutants in Drosophila...
- Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst componentsSunil Q Mehta
Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Neuron 46:219-32. 2005..Additionally, sec15 mutant neurons fail to localize other exocyst members like Sec5 and Sec8, but not Sec6, to neuronal terminals. However, loss of sec15 does not cause cell lethality in contrast to loss of sec5 or sec6...
- Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cellsSlobodan Beronja
Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
J Cell Biol 169:635-46. 2005..We characterized Drosophila Sec6, a component of the exocyst complex that is believed to tether secretory vesicles to specific plasma membrane sites...
- Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persistsMala Murthy
Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA
Neuron 37:433-47. 2003The exocyst (Sec6/8) complex is necessary for secretion in yeast and has been postulated to establish polarity by directing vesicle fusion to specific sites along the plasma membrane...
- Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membraneJohanna Langevin
Polarité Cellulaire chez la drosophile, UMR 144, Paris, France
Dev Cell 9:365-76. 2005..Loss of function of the Drosophila exocyst components sec5, sec6, and sec15 in epithelial cells results in DE-Cad accumulation in an enlarged Rab11 recycling endosomal compartment ..
- The Drosophila homolog of the Exo84 exocyst subunit promotes apical epithelial identityJ Todd Blankenship
Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
J Cell Sci 120:3099-110. 2007..These results suggest that epithelial polarity in the Drosophila embryo is actively maintained by exocyst-dependent apical localization of the Crumbs transmembrane protein...
- Three mechanisms control E-cadherin localization to the zonula adherensInnokenty Woichansky
Department of Cell and Molecular Biology and Division of Signaling and Functional Genomics at the German Cancer Research Center DKFZ, Medical Faculty Mannheim, Heidelberg University, Ludolf Krehl Strasse 13 17, D 68167 Mannheim, Germany
Nat Commun 7:10834. 2016..Differential activation of these pathways could facilitate cell shape changes during morphogenesis, while their misregulation compromises cell adhesion and tissue architecture in differentiated epithelia. ..
- Regulation of dendrite growth and maintenance by exocytosisYun Peng
Department of Biology, University of Washington, Seattle, WA 98195, USA
J Cell Sci 128:4279-92. 2015....
- Regulation of Notch signaling and endocytosis by the Lgl neoplastic tumor suppressorMarta Portela
a Cell Cycle and Development Laboratory Research Division Peter MacCallum Cancer Centre Melbourne, Victoria, Australia
Cell Cycle 14:1496-506. 2015..In this extraview, we provide additional data on the regulation of Notch signaling and endocytosis by Lgl, and discuss possible mechanisms by which Lgl depletion contributes to signaling pathway defects and tumorigenesis. ..
- Oncogenic Ras stimulates Eiger/TNF exocytosis to promote growthChiswili Chabu
Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
Development 141:4729-39. 2014..Our findings highlight important cell-intrinsic and cell-extrinsic roles of exocytosis during oncogenic growth and provide a new class of synthetic suppressors for targeted therapy approaches. ..
- Exocyst-mediated membrane trafficking is required for branch outgrowth in Drosophila tracheal terminal cellsTiffani A Jones
Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
Dev Biol 390:41-50. 2014..Together, our results suggest a model where exocyst mediated vesicle trafficking facilitates branch outgrowth, while de novo branching requires cooperation between the PAR and exocyst complexes. ..
- Endophilin B is required for the Drosophila oocyte to endocytose yolk downstream of OskarYi Cheng Tsai
Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Tao Yuan, 333, Taiwan
Development 141:563-73. 2014....
- par-1, atypical pkc, and PP2A/B55 sur-6 are implicated in the regulation of exocyst-mediated membrane trafficking in Caenorhabditis elegansYaming Jiu
Institute of Biotechnology, Research Program in Cell and Molecular Biology, 00014 University of Helsinki, Helsinki, Finland
G3 (Bethesda) 4:173-83. 2014....
- Exorcising the exocyst complexMargaret R Heider
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
Traffic 13:898-907. 2012..In this review, we discuss current knowledge of exocyst architecture, assembly, regulation and its roles in a variety of cellular trafficking pathways...
- Polychaetoid controls patterning by modulating adhesion in the Drosophila pupal retinaMidori J Seppa
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
Dev Biol 318:1-16. 2008..Our results suggest that Pyd modulates adherens junction strength and Roughest-mediated preferential cell adhesion...
- Phosphatidylinositol 4,5-bisphosphate directs spermatid cell polarity and exocyst localization in DrosophilaLacramioara Fabian
Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 1L7, Canada
Mol Biol Cell 21:1546-55. 2010..Our data are consistent with a mechanism in which localized synthesis of PIP(2) recruits the exocyst to promote targeted membrane delivery and polarization of the elongating cysts...
- Spatial restriction of receptor tyrosine kinase activity through a polarized endocytic cycle controls border cell migrationGloria Assaker
Institute for Research in Immunology and Cancer and Department of Pathology and Cell Biology, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
Proc Natl Acad Sci U S A 107:22558-63. 2010..Together, our data demonstrate a fundamental role for a plasma membrane-endosome trafficking cycle in the maintenance of active RTK at the leading edge of border cells during their migration...
- Local BMP receptor activation at adherens junctions in the Drosophila germline stem cell nicheMarcus Michel
Center for Regenerative Therapies Dresden CRTD, TU Dresden, Tatzberg, Germany
Nat Commun 2:415. 2011..We, therefore, propose that local generation of the BMP signal is achieved through shared use of the Cadherin transport machinery...
- Apical-basal polarity in Drosophila neuroblasts is independent of vesicular traffickingNils Halbsgut
Stammzellbiologie, Abteilung Anatomie und Zellbiologie, Georg August Universitat Gottingen, 37077 Gottingen, Germany
Mol Biol Cell 22:4373-9. 2011..Surprisingly, we found that none of these mutations affected NB polarity, demonstrating that NB cortical polarity is independent of plasma membrane polarity and that the PAR proteins function in a cell type-specific manner...
- In vivo coupling of cell elongation and lumen formation in a single cellLouis Gervais
Institut de Biologia Molecular de Barcelona CSIC, Baldiri Reixac 10 12, 08028 Barcelona, Spain
Curr Biol 20:359-66. 2010..Given the similarities in the formation of fine respiratory tubes and capillaries, we propose that an inward membrane growth model could account for lumen formation in both processes...
- Drosophila Cip4 and WASp define a branch of the Cdc42-Par6-aPKC pathway regulating E-cadherin endocytosisAndrea Leibfried
Institut Curie, Centre National de la Recherche, UMR 144, Equipe Polarité Cellulaire chez la Drosophile, 26 Rue d Ulm, 75248 Paris Cedex 05, France
Curr Biol 18:1639-48. 2008..A mechanism regulating E-Cadherin (E-Cad) exocytosis to the AJs has implicated proteins of the exocyst complex, but mechanisms regulating E-Cad endocytosis from the AJs remain less well understood...
- Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in DrosophilaGabor Juhasz
Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
Genes Dev 21:3061-6. 2007..Thus, normal levels of autophagy are crucial for stress survival and continuous cellular renewal, but not metamorphosis...
- Experimental selection for Drosophila survival in extremely low O(2) environmentDan Zhou
Department of Pediatrics, Section of Respiratory Medicine, and Neuroscience, University of California San Diego, La Jolla, California, United States of America
PLoS ONE 2:e490. 2007..The current experiments were designed to determine the genetic basis for adaptation to long term low O(2) environments...
- P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogasterKoen J T Venken
Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
Science 314:1747-51. 2006..This transgenesis platform should greatly facilitate structure/function analyses of most Drosophila genes...
- The agrin/perlecan-related protein eyes shut is essential for epithelial lumen formation in the Drosophila retinaNicole Husain
Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
Dev Cell 11:483-93. 2006..Our findings show that the secretion of a proteoglycan into the apical matrix is critical for the formation of epithelial lumina in the fly retina...
- Recycling endosomesSven C D Van IJzendoorn
Department of Cell Biology, Section Membrane Cell Biology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands
J Cell Sci 119:1679-81. 2006
- The exocyst component Sec5 is present on endocytic vesicles in the oocyte of Drosophila melanogasterBernhard Sommer
Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, England, UK
J Cell Biol 169:953-63. 2005..Thus, the exocyst may act in both Golgi to plasma membrane traffic and endocytic cycling, and hence in oocytes is recruited to clathrin-coated pits to facilitate the rapid recycling of Yolkless...