Sec6

Summary

Gene Symbol: Sec6
Description: Secretory 6
Alias: CG5341, Dmel\CG5341, Dsec6, Sec6p, dsec6, sec 6, sec6, CG5341 gene product from transcript CG5341-RA, CG5341-PA, Sec6 ortholog, Sec6-PA, sec6, secretory 6
Species: fruit fly

Top Publications

  1. ncbi Sec6 mutations and the Drosophila exocyst complex
    Mala Murthy
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Cell Sci 118:1139-50. 2005
  2. ncbi Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components
    Sunil Q Mehta
    Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Neuron 46:219-32. 2005
  3. pmc Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells
    Slobodan Beronja
    Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    J Cell Biol 169:635-46. 2005
  4. ncbi Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists
    Mala Murthy
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA
    Neuron 37:433-47. 2003
  5. ncbi Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane
    Johanna Langevin
    Polarité Cellulaire chez la drosophile, UMR 144, Paris, France
    Dev Cell 9:365-76. 2005
  6. ncbi The Drosophila homolog of the Exo84 exocyst subunit promotes apical epithelial identity
    J Todd Blankenship
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    J Cell Sci 120:3099-110. 2007
  7. pmc Three mechanisms control E-cadherin localization to the zonula adherens
    Innokenty Woichansky
    Department of Cell and Molecular Biology and Division of Signaling and Functional Genomics at the German Cancer Research Center DKFZ, Medical Faculty Mannheim, Heidelberg University, Ludolf Krehl Strasse 13 17, D 68167 Mannheim, Germany
    Nat Commun 7:10834. 2016
  8. pmc Regulation of dendrite growth and maintenance by exocytosis
    Yun Peng
    Department of Biology, University of Washington, Seattle, WA 98195, USA
    J Cell Sci 128:4279-92. 2015
  9. pmc Regulation of Notch signaling and endocytosis by the Lgl neoplastic tumor suppressor
    Marta Portela
    a Cell Cycle and Development Laboratory Research Division Peter MacCallum Cancer Centre Melbourne, Victoria, Australia
    Cell Cycle 14:1496-506. 2015
  10. pmc Oncogenic Ras stimulates Eiger/TNF exocytosis to promote growth
    Chiswili Chabu
    Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Development 141:4729-39. 2014

Scientific Experts

  • Sven C D Van IJzendoorn
  • J Todd Blankenship
  • Mala Murthy
  • Louis Gervais
  • Innokenty Woichansky
  • Yun Peng
  • Marta Portela
  • Yaming Jiu
  • Yi Cheng Tsai
  • Chiswili Chabu
  • Tiffani A Jones
  • Ulrich Tepass
  • Slobodan Beronja
  • Margaret R Heider
  • Marcus Michel
  • Nils Halbsgut
  • Lacramioara Fabian
  • Gloria Assaker
  • Midori J Seppa
  • Andrea Leibfried
  • Dan Zhou
  • Gabor Juhasz
  • Yohanns Bellaiche
  • Matthew J Morgan
  • Nicole Husain
  • Koen J T Venken
  • Milena Pellikka
  • Hugo J Bellen
  • Bernhard Sommer
  • Sunil Q Mehta
  • Johanna Langevin
  • Thomas L Schwarz
  • Carlo Antonio Beretta
  • Veit Riechmann
  • Nicola Berns
  • Kimberly Rowland
  • Jiae Lee
  • Linda M Parsons
  • Yuhui Wen
  • Helena E Richardson
  • Hope Hua
  • Nicola A Grzeschik
  • Michael D Kim
  • Shweta Lavania
  • Jay Z Parrish
  • Nicole Carlson
  • Jussi Jantti
  • Tian Xu
  • Ville Hietakangas
  • Lois Tang
  • Linda S Nikolova
  • Wei Hao Lee
  • Thomas R Burglin
  • Yi Chen Li
  • Yu Wei Chang
  • Willisa Liou
  • Yanbo Liu
  • Wei Chiang
  • Kiran Hasygar
  • Carina I Holmberg
  • Li Mei Pai
  • Akira Nakamura
  • Pei yu Wang
  • Mark M Metzstein
  • Tsubasa Tanaka
  • Ani Schjelderup
  • Mary Munson
  • Laura Isabel Zimmermann
  • Raquel Pérez-Palencia
  • Andreas Wodarz
  • Karen Linnemannstöns
  • Christian Bökel
  • Adam P Kupinski
  • Isabel Raabe
  • Julie A Brill
  • Gregory Emery
  • Gordon Polevoy
  • Jordi Casanova
  • Tatsuhiko Noguchi
  • Stefanie K Wculek
  • Margaret T Fuller
  • Kishan Bellamkonda
  • Marcos Gonzalez-Gaitan
  • Damien Ramel
  • Antoine Guichet
  • Janet Rollins
  • Ho Chun Wei
  • Sujin Bao
  • Ruth I Johnson
  • Ross L Cagan

Detail Information

Publications27

  1. ncbi Sec6 mutations and the Drosophila exocyst complex
    Mala Murthy
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Cell Sci 118:1139-50. 2005
    To allow a detailed analysis of exocyst function in multicellular organisms, we have generated sec6 mutants in Drosophila...
  2. ncbi Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components
    Sunil Q Mehta
    Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Neuron 46:219-32. 2005
    ..Additionally, sec15 mutant neurons fail to localize other exocyst members like Sec5 and Sec8, but not Sec6, to neuronal terminals. However, loss of sec15 does not cause cell lethality in contrast to loss of sec5 or sec6...
  3. pmc Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells
    Slobodan Beronja
    Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    J Cell Biol 169:635-46. 2005
    ..We characterized Drosophila Sec6, a component of the exocyst complex that is believed to tether secretory vesicles to specific plasma membrane sites...
  4. ncbi Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists
    Mala Murthy
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA
    Neuron 37:433-47. 2003
    The exocyst (Sec6/8) complex is necessary for secretion in yeast and has been postulated to establish polarity by directing vesicle fusion to specific sites along the plasma membrane...
  5. ncbi Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane
    Johanna Langevin
    Polarité Cellulaire chez la drosophile, UMR 144, Paris, France
    Dev Cell 9:365-76. 2005
    ..Loss of function of the Drosophila exocyst components sec5, sec6, and sec15 in epithelial cells results in DE-Cad accumulation in an enlarged Rab11 recycling endosomal compartment ..
  6. ncbi The Drosophila homolog of the Exo84 exocyst subunit promotes apical epithelial identity
    J Todd Blankenship
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    J Cell Sci 120:3099-110. 2007
    ..These results suggest that epithelial polarity in the Drosophila embryo is actively maintained by exocyst-dependent apical localization of the Crumbs transmembrane protein...
  7. pmc Three mechanisms control E-cadherin localization to the zonula adherens
    Innokenty Woichansky
    Department of Cell and Molecular Biology and Division of Signaling and Functional Genomics at the German Cancer Research Center DKFZ, Medical Faculty Mannheim, Heidelberg University, Ludolf Krehl Strasse 13 17, D 68167 Mannheim, Germany
    Nat Commun 7:10834. 2016
    ..Differential activation of these pathways could facilitate cell shape changes during morphogenesis, while their misregulation compromises cell adhesion and tissue architecture in differentiated epithelia. ..
  8. pmc Regulation of dendrite growth and maintenance by exocytosis
    Yun Peng
    Department of Biology, University of Washington, Seattle, WA 98195, USA
    J Cell Sci 128:4279-92. 2015
    ....
  9. pmc Regulation of Notch signaling and endocytosis by the Lgl neoplastic tumor suppressor
    Marta Portela
    a Cell Cycle and Development Laboratory Research Division Peter MacCallum Cancer Centre Melbourne, Victoria, Australia
    Cell Cycle 14:1496-506. 2015
    ..In this extraview, we provide additional data on the regulation of Notch signaling and endocytosis by Lgl, and discuss possible mechanisms by which Lgl depletion contributes to signaling pathway defects and tumorigenesis. ..
  10. pmc Oncogenic Ras stimulates Eiger/TNF exocytosis to promote growth
    Chiswili Chabu
    Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Development 141:4729-39. 2014
    ..Our findings highlight important cell-intrinsic and cell-extrinsic roles of exocytosis during oncogenic growth and provide a new class of synthetic suppressors for targeted therapy approaches. ..
  11. pmc Exocyst-mediated membrane trafficking is required for branch outgrowth in Drosophila tracheal terminal cells
    Tiffani A Jones
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Dev Biol 390:41-50. 2014
    ..Together, our results suggest a model where exocyst mediated vesicle trafficking facilitates branch outgrowth, while de novo branching requires cooperation between the PAR and exocyst complexes. ..
  12. doi Endophilin B is required for the Drosophila oocyte to endocytose yolk downstream of Oskar
    Yi Cheng Tsai
    Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Tao Yuan, 333, Taiwan
    Development 141:563-73. 2014
    ....
  13. pmc par-1, atypical pkc, and PP2A/B55 sur-6 are implicated in the regulation of exocyst-mediated membrane trafficking in Caenorhabditis elegans
    Yaming Jiu
    Institute of Biotechnology, Research Program in Cell and Molecular Biology, 00014 University of Helsinki, Helsinki, Finland
    G3 (Bethesda) 4:173-83. 2014
    ....
  14. pmc Exorcising the exocyst complex
    Margaret R Heider
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Traffic 13:898-907. 2012
    ..In this review, we discuss current knowledge of exocyst architecture, assembly, regulation and its roles in a variety of cellular trafficking pathways...
  15. pmc Polychaetoid controls patterning by modulating adhesion in the Drosophila pupal retina
    Midori J Seppa
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    Dev Biol 318:1-16. 2008
    ..Our results suggest that Pyd modulates adherens junction strength and Roughest-mediated preferential cell adhesion...
  16. pmc Phosphatidylinositol 4,5-bisphosphate directs spermatid cell polarity and exocyst localization in Drosophila
    Lacramioara Fabian
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 1L7, Canada
    Mol Biol Cell 21:1546-55. 2010
    ..Our data are consistent with a mechanism in which localized synthesis of PIP(2) recruits the exocyst to promote targeted membrane delivery and polarization of the elongating cysts...
  17. pmc Spatial restriction of receptor tyrosine kinase activity through a polarized endocytic cycle controls border cell migration
    Gloria Assaker
    Institute for Research in Immunology and Cancer and Department of Pathology and Cell Biology, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    Proc Natl Acad Sci U S A 107:22558-63. 2010
    ..Together, our data demonstrate a fundamental role for a plasma membrane-endosome trafficking cycle in the maintenance of active RTK at the leading edge of border cells during their migration...
  18. doi Local BMP receptor activation at adherens junctions in the Drosophila germline stem cell niche
    Marcus Michel
    Center for Regenerative Therapies Dresden CRTD, TU Dresden, Tatzberg, Germany
    Nat Commun 2:415. 2011
    ..We, therefore, propose that local generation of the BMP signal is achieved through shared use of the Cadherin transport machinery...
  19. pmc Apical-basal polarity in Drosophila neuroblasts is independent of vesicular trafficking
    Nils Halbsgut
    Stammzellbiologie, Abteilung Anatomie und Zellbiologie, Georg August Universitat Gottingen, 37077 Gottingen, Germany
    Mol Biol Cell 22:4373-9. 2011
    ..Surprisingly, we found that none of these mutations affected NB polarity, demonstrating that NB cortical polarity is independent of plasma membrane polarity and that the PAR proteins function in a cell type-specific manner...
  20. doi In vivo coupling of cell elongation and lumen formation in a single cell
    Louis Gervais
    Institut de Biologia Molecular de Barcelona CSIC, Baldiri Reixac 10 12, 08028 Barcelona, Spain
    Curr Biol 20:359-66. 2010
    ..Given the similarities in the formation of fine respiratory tubes and capillaries, we propose that an inward membrane growth model could account for lumen formation in both processes...
  21. doi Drosophila Cip4 and WASp define a branch of the Cdc42-Par6-aPKC pathway regulating E-cadherin endocytosis
    Andrea Leibfried
    Institut Curie, Centre National de la Recherche, UMR 144, Equipe Polarité Cellulaire chez la Drosophile, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Curr Biol 18:1639-48. 2008
    ..A mechanism regulating E-Cadherin (E-Cad) exocytosis to the AJs has implicated proteins of the exocyst complex, but mechanisms regulating E-Cad endocytosis from the AJs remain less well understood...
  22. pmc Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila
    Gabor Juhasz
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Genes Dev 21:3061-6. 2007
    ..Thus, normal levels of autophagy are crucial for stress survival and continuous cellular renewal, but not metamorphosis...
  23. pmc Experimental selection for Drosophila survival in extremely low O(2) environment
    Dan Zhou
    Department of Pediatrics, Section of Respiratory Medicine, and Neuroscience, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 2:e490. 2007
    ..The current experiments were designed to determine the genetic basis for adaptation to long term low O(2) environments...
  24. ncbi P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster
    Koen J T Venken
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 314:1747-51. 2006
    ..This transgenesis platform should greatly facilitate structure/function analyses of most Drosophila genes...
  25. ncbi The agrin/perlecan-related protein eyes shut is essential for epithelial lumen formation in the Drosophila retina
    Nicole Husain
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    Dev Cell 11:483-93. 2006
    ..Our findings show that the secretion of a proteoglycan into the apical matrix is critical for the formation of epithelial lumina in the fly retina...
  26. ncbi Recycling endosomes
    Sven C D Van IJzendoorn
    Department of Cell Biology, Section Membrane Cell Biology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    J Cell Sci 119:1679-81. 2006
  27. pmc The exocyst component Sec5 is present on endocytic vesicles in the oocyte of Drosophila melanogaster
    Bernhard Sommer
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, England, UK
    J Cell Biol 169:953-63. 2005
    ..Thus, the exocyst may act in both Golgi to plasma membrane traffic and endocytic cycling, and hence in oocytes is recruited to clathrin-coated pits to facilitate the rapid recycling of Yolkless...