Sec15

Summary

Gene Symbol: Sec15
Description: Secretory 15
Alias: 3R41, CG7034, Dmel\CG7034, Sec15p, dsec15, sec15, CG7034 gene product from transcript CG7034-RA, CG7034-PA, Sec15 ortholog, Sec15-PA, sec15, secretory 15
Species: fruit fly

Top Publications

  1. ncbi Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components
    Sunil Q Mehta
    Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Neuron 46:219-32. 2005
  2. ncbi Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors
    Hamed Jafar-Nejad
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Dev Cell 9:351-63. 2005
  3. ncbi Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists
    Mala Murthy
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA
    Neuron 37:433-47. 2003
  4. ncbi Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane
    Johanna Langevin
    Polarité Cellulaire chez la drosophile, UMR 144, Paris, France
    Dev Cell 9:365-76. 2005
  5. pmc Ral GTPase and the exocyst regulate autophagy in a tissue-specific manner
    Kirsten Tracy
    Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA
    EMBO Rep 17:110-21. 2016
  6. pmc Regulation of dendrite growth and maintenance by exocytosis
    Yun Peng
    Department of Biology, University of Washington, Seattle, WA 98195, USA
    J Cell Sci 128:4279-92. 2015
  7. pmc The guanine exchange factor Gartenzwerg and the small GTPase Arl1 function in the same pathway with Arfaptin during synapse growth
    Leo Chang
    Department of Physiology, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Biol Open 4:947-53. 2015
  8. pmc The Spectrin cytoskeleton regulates the Hippo signalling pathway
    Georgina C Fletcher
    Epithelial Biology Laboratory, Cancer Research UK London Research Institute, London, UK
    EMBO J 34:940-54. 2015
  9. pmc Oncogenic Ras stimulates Eiger/TNF exocytosis to promote growth
    Chiswili Chabu
    Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Development 141:4729-39. 2014
  10. pmc Exocyst-mediated membrane trafficking is required for branch outgrowth in Drosophila tracheal terminal cells
    Tiffani A Jones
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Dev Biol 390:41-50. 2014

Scientific Experts

  • Peter Robin Hiesinger
  • Sven C D Van IJzendoorn
  • Annabel Guichard
  • Hugo J Bellen
  • Sunil Q Mehta
  • Kirsten Tracy
  • Georgina C Fletcher
  • Yun Peng
  • Leo Chang
  • Yohanns Bellaiche
  • Tiffani A Jones
  • Yaming Jiu
  • Chiswili Chabu
  • Johanna Langevin
  • Margaret R Heider
  • Ethan Bier
  • Victor Nizet
  • Beatriz Cruz-Moreno
  • Nina M van Sorge
  • Nils Halbsgut
  • Jiang Xu
  • Chao Tong
  • Marcus Michel
  • Mala Murthy
  • Sarah L Windler
  • Gloria Assaker
  • W Ryan Williamson
  • Najate Benhra
  • Xin Tong
  • Andrea Leibfried
  • Matthew J Morgan
  • Maria Balakireva
  • Ciara M Gallagher
  • Juergen A Knoblich
  • Sandra Aresta
  • Jacques Camonis
  • Shuya Wu
  • Hamed Jafar-Nejad
  • W Gregory Somers
  • Panagiotis D Velentzas
  • Eric H Baehrecke
  • Kimberly Rowland
  • Benjamin A Eaton
  • Ahmed Elbediwy
  • Nicole Carlson
  • Yuhui Wen
  • Paulo S Ribeiro
  • Ichha Khanal
  • Michael D Kim
  • Jay Z Parrish
  • Jiae Lee
  • Tabita Kreko-Pierce
  • Nic Tapon
  • Hope Hua
  • Shweta Lavania
  • Barry J Thompson
  • Yanbo Liu
  • Mark M Metzstein
  • Thomas R Burglin
  • Lois Tang
  • Ani Schjelderup
  • Kiran Hasygar
  • Carina I Holmberg
  • Tian Xu
  • Linda S Nikolova
  • Jussi Jantti
  • Ville Hietakangas
  • Berenice Aguilar
  • Adrianne A Kurkciyan
  • Declan F McCole
  • Saiyu Hang
  • Zhipeng Wang
  • Paula Watnick
  • Beatriz Cruz Cruz-Moreno
  • Jennifer Kuang
  • Guillaume P Pineton de Chambrun
  • Mary Munson
  • Christian Bökel
  • An Chi Tien
  • Adam P Kupinski
  • Akhila Rajan
  • Isabel Raabe
  • Cristin Mattione
  • Laura Isabel Zimmermann
  • Tomoko Ohyama
  • Andreas Wodarz
  • Raquel Pérez-Palencia
  • Karen Linnemannstöns
  • Robert S Cohen
  • Nicholas Bogard

Detail Information

Publications30

  1. ncbi Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components
    Sunil Q Mehta
    Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Neuron 46:219-32. 2005
    ..We have isolated an exocyst component, sec15, in a screen for genes required for synaptic specificity...
  2. ncbi Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors
    Hamed Jafar-Nejad
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Dev Cell 9:351-63. 2005
    ..In a genetic screen designed to identify novel players in this process, we have isolated a mutation in Drosophila sec15, which encodes a component of the exocyst, an evolutionarily conserved complex implicated in intracellular vesicle ..
  3. ncbi Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists
    Mala Murthy
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA
    Neuron 37:433-47. 2003
    ..In this regard, sec5 differs from the homologs of other yeast exocytosis genes that are required for both neuronal trafficking pathways...
  4. ncbi Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane
    Johanna Langevin
    Polarité Cellulaire chez la drosophile, UMR 144, Paris, France
    Dev Cell 9:365-76. 2005
    ..Loss of function of the Drosophila exocyst components sec5, sec6, and sec15 in epithelial cells results in DE-Cad accumulation in an enlarged Rab11 recycling endosomal compartment and ..
  5. pmc Ral GTPase and the exocyst regulate autophagy in a tissue-specific manner
    Kirsten Tracy
    Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA
    EMBO Rep 17:110-21. 2016
    ..These data indicate that Ral and the exocyst regulate autophagy in a context-dependent manner, and that in dying salivary glands, Ral mediates autophagy, at least in part, by regulation of Notch. ..
  6. pmc Regulation of dendrite growth and maintenance by exocytosis
    Yun Peng
    Department of Biology, University of Washington, Seattle, WA 98195, USA
    J Cell Sci 128:4279-92. 2015
    ....
  7. pmc The guanine exchange factor Gartenzwerg and the small GTPase Arl1 function in the same pathway with Arfaptin during synapse growth
    Leo Chang
    Department of Physiology, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Biol Open 4:947-53. 2015
    ..Our data define a new signaling pathway composed of Arfaptin, Arl1, and Garz, required for the generation of normal synapse morphology...
  8. pmc The Spectrin cytoskeleton regulates the Hippo signalling pathway
    Georgina C Fletcher
    Epithelial Biology Laboratory, Cancer Research UK London Research Institute, London, UK
    EMBO J 34:940-54. 2015
    ..Our findings identify both apical and basolateral Spectrins as regulators of Hippo signalling and suggest Spectrins as potential mechanosensors...
  9. pmc Oncogenic Ras stimulates Eiger/TNF exocytosis to promote growth
    Chiswili Chabu
    Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Development 141:4729-39. 2014
    ..We identified the exocytosis component Sec15 as a synthetic suppressor of oncogenic Ras in an in vivo Drosophila mosaic screen...
  10. pmc Exocyst-mediated membrane trafficking is required for branch outgrowth in Drosophila tracheal terminal cells
    Tiffani A Jones
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Dev Biol 390:41-50. 2014
    ..Together, our results suggest a model where exocyst mediated vesicle trafficking facilitates branch outgrowth, while de novo branching requires cooperation between the PAR and exocyst complexes. ..
  11. pmc par-1, atypical pkc, and PP2A/B55 sur-6 are implicated in the regulation of exocyst-mediated membrane trafficking in Caenorhabditis elegans
    Yaming Jiu
    Institute of Biotechnology, Research Program in Cell and Molecular Biology, 00014 University of Helsinki, Helsinki, Finland
    G3 (Bethesda) 4:173-83. 2014
    ....
  12. pmc Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions
    Annabel Guichard
    Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell Host Microbe 14:294-305. 2013
    ..cholerae infection, all of which can be rescued by Rab11 overexpression. These barrier-disrupting effects of CtxA may act in parallel with Cl(-) secretion to drive the pathophysiology of cholera...
  13. pmc Exorcising the exocyst complex
    Margaret R Heider
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Traffic 13:898-907. 2012
    ..In this review, we discuss current knowledge of exocyst architecture, assembly, regulation and its roles in a variety of cellular trafficking pathways...
  14. pmc The Ral/exocyst effector complex counters c-Jun N-terminal kinase-dependent apoptosis in Drosophila melanogaster
    Maria Balakireva
    Institut Curie, Inserm U528, Groupe d Analyse des Réseaux de Transduction ART, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Mol Cell Biol 26:8953-63. 2006
    ..We propose that the exocyst complex is Ral executioner in the JNK pathway and that a cascade from Ral to the exocyst to HGK would be a molecular basis of Ral action on JNK...
  15. pmc A dual function of V0-ATPase a1 provides an endolysosomal degradation mechanism in Drosophila melanogaster photoreceptors
    W Ryan Williamson
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Cell Biol 189:885-99. 2010
    ..We propose that V100 exerts a temporally integrated dual function that increases neuronal degradative capacity...
  16. doi Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst
    Annabel Guichard
    Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0349, USA
    Nature 467:854-8. 2010
    ..Here we use Drosophila melanogaster to identify the Rab11/Sec15 exocyst, which acts at the last step of endocytic recycling, as a novel target of both EF and LF...
  17. pmc Spatial restriction of receptor tyrosine kinase activity through a polarized endocytic cycle controls border cell migration
    Gloria Assaker
    Institute for Research in Immunology and Cancer and Department of Pathology and Cell Biology, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    Proc Natl Acad Sci U S A 107:22558-63. 2010
    ..In addition, we demonstrate that the exocyst component Sec15 is distributed in structures that are polarized during the migration process in a Rab11-dependent manner and that ..
  18. pmc Rab11 is required for epithelial cell viability, terminal differentiation, and suppression of tumor-like growth in the Drosophila egg chamber
    Jiang Xu
    Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, United States of America
    PLoS ONE 6:e20180. 2011
    ....
  19. doi Local BMP receptor activation at adherens junctions in the Drosophila germline stem cell niche
    Marcus Michel
    Center for Regenerative Therapies Dresden CRTD, TU Dresden, Tatzberg, Germany
    Nat Commun 2:415. 2011
    ..We, therefore, propose that local generation of the BMP signal is achieved through shared use of the Cadherin transport machinery...
  20. pmc Rich regulates target specificity of photoreceptor cells and N-cadherin trafficking in the Drosophila visual system via Rab6
    Chao Tong
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 71:447-59. 2011
    ..in the photoreceptor cell synapses but not of other proteins implicated in target recognition, including Sec15, DLAR, Jelly belly, and PTP69D...
  21. pmc Apical-basal polarity in Drosophila neuroblasts is independent of vesicular trafficking
    Nils Halbsgut
    Stammzellbiologie, Abteilung Anatomie und Zellbiologie, Georg August Universitat Gottingen, 37077 Gottingen, Germany
    Mol Biol Cell 22:4373-9. 2011
    ..Surprisingly, we found that none of these mutations affected NB polarity, demonstrating that NB cortical polarity is independent of plasma membrane polarity and that the PAR proteins function in a cell type-specific manner...
  22. pmc Neuralized promotes basal to apical transcytosis of delta in epithelial cells
    Najate Benhra
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 6061, Institut de Génétique et Développement de Rennes, Universite de Rennes 1, 35000 Rennes, France
    Mol Biol Cell 21:2078-86. 2010
    ....
  23. ncbi Recycling polarity
    W Gregory Somers
    Temasek Lifesciences Laboratory, The National University of Singapore
    Dev Cell 9:312-3. 2005
    ..Three current papers in Cell and in this issue of Developmental Cell highlight the role of the exocyst in recycling of membrane proteins from endosomes to the plasma membrane in asymmetric cell division and polarized epithelial cells...
  24. ncbi Sec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivo
    Shuya Wu
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Struct Mol Biol 12:879-85. 2005
    b>Sec15, a component of the exocyst, recognizes vesicle-associated Rab GTPases, helps target transport vesicles to the budding sites in yeast and is thought to recruit other exocyst proteins...
  25. ncbi Recycling endosomes
    Sven C D Van IJzendoorn
    Department of Cell Biology, Section Membrane Cell Biology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    J Cell Sci 119:1679-81. 2006
  26. pmc Activity-independent prespecification of synaptic partners in the visual map of Drosophila
    P Robin Hiesinger
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Biol 16:1835-43. 2006
    ..syt), vesicle endocytosis (synj), the trafficking of specific guidance molecules during photoreceptor targeting (sec15), a specific guidance receptor required for visual map formation (Dlar), and 57 other novel synaptic mutants ..
  27. ncbi The conserved c2 domain protein lethal (2) giant discs regulates protein trafficking in Drosophila
    Ciara M Gallagher
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Dev Cell 11:641-53. 2006
    ..Our experiments suggest that Lgd is a critical regulator of endocytosis that is not present in yeast and acts in the degradative pathway after Hrs...
  28. doi Drosophila Cip4 and WASp define a branch of the Cdc42-Par6-aPKC pathway regulating E-cadherin endocytosis
    Andrea Leibfried
    Institut Curie, Centre National de la Recherche, UMR 144, Equipe Polarité Cellulaire chez la Drosophile, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Curr Biol 18:1639-48. 2008
    ..A mechanism regulating E-Cadherin (E-Cad) exocytosis to the AJs has implicated proteins of the exocyst complex, but mechanisms regulating E-Cad endocytosis from the AJs remain less well understood...
  29. pmc Numb independently antagonizes Sanpodo membrane targeting and Notch signaling in Drosophila sensory organ precursor cells
    Xin Tong
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Mol Biol Cell 21:802-10. 2010
    ....
  30. pmc Endocytic internalization routes required for delta/notch signaling
    Sarah L Windler
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720 3200, USA
    Curr Biol 20:538-43. 2010
    ..The absolute requirement for dynamin-dependent endocytosis but not endosomal entry or Rab11 activity supports "pulling force" rather than "recycling" models for Delta activation...