run

Summary

Gene Symbol: run
Description: runt
Alias: AA33, CG1849, Dmel\CG1849, LB5, P235, RUN, Rnt, Run, Runt, l(1)19Ea, l(1)AA33, l(1)B2/13.1, l(1)LB9, lLB5, leg, CG1849 gene product from transcript CG1849-RC, CG1849-PA, CG1849-PB, CG1849-PC, legless, run-PA, run-PB, run-PC, section 1, section 2
Species: fruit fly

Top Publications

  1. ncbi Mutations affecting segment number and polarity in Drosophila
    C Nusslein-Volhard
    Nature 287:795-801. 1980
  2. pmc Rho-kinase directs Bazooka/Par-3 planar polarity during Drosophila axis elongation
    Sérgio de Matos Simões
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA
    Dev Cell 19:377-88. 2010
  3. ncbi Early and late periodic patterns of even skipped expression are controlled by distinct regulatory elements that respond to different spatial cues
    T Goto
    Department of Biochemistry, Harvard University, Cambridge, Massachusetts 02138
    Cell 57:413-22. 1989
  4. ncbi Direct activation of Sex-lethal transcription by the Drosophila runt protein
    S G Kramer
    Department of Biochemistry and Cell Biology and the Institute for Cell and Developmental Biology, State University of New York at Stony Brook, Stony Brook, New York 11794 5215, USA
    Development 126:191-200. 1999
  5. pmc Robo-3--mediated repulsive interactions guide R8 axons during Drosophila visual system development
    Kartik S Pappu
    Department of Biological Chemistry, The Howard Hughes Medical Institute, The David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 108:7571-6. 2011
  6. ncbi Zebra patterns in fly embryos: activation of stripes or repression of interstripes?
    S B Carroll
    Laboratory of Molecular Biology, University of Wisconsin, Madison 53706
    Cell 60:9-16. 1990
  7. ncbi Patterning of cells in the Drosophila eye by Lozenge, which shares homologous domains with AML1
    A Daga
    Department of Molecular, Cell and Developmental Biology, Molecular Biology Institute, Los Angeles
    Genes Dev 10:1194-205. 1996
  8. ncbi Rapid preparation of a panel of polyclonal antibodies to Drosophila segmentation proteins
    D Kosman
    Brookdale Center for Molecular Biology, Box 1126, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Genes Evol 208:290-4. 1998
  9. pmc Pdm and Castor specify late-born motor neuron identity in the NB7-1 lineage
    Ruth Grosskortenhaus
    Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, 97403, USA
    Genes Dev 20:2618-27. 2006
  10. ncbi The Drosophila segmentation gene runt has an extended cis-regulatory region that is required for vital expression at other stages of development
    B A Butler
    Department of Biochemistry and Cell Biology, State University of New York, Stony Brook 11794
    Mech Dev 39:17-28. 1992

Research Grants

  1. Signaling Mechanisms of the Drosophila JAK/STAT Pathway
    Hong Luo; Fiscal Year: 2003
  2. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
  3. Technique to Obtain Intra-Locus Deletions in Eukaryotes
    Charles Dearolf; Fiscal Year: 2003
  4. A Novel Mutagenesis Technology for Drosophila
    Charles Dearolf; Fiscal Year: 2003
  5. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
  6. BH3-only protein BNIP3 in tumor progression
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2006
  7. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
  8. Apoptosis Signaling: BH3 to BH123 Proteins
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2008
  9. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
  10. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications123 found, 100 shown here

  1. ncbi Mutations affecting segment number and polarity in Drosophila
    C Nusslein-Volhard
    Nature 287:795-801. 1980
    ....
  2. pmc Rho-kinase directs Bazooka/Par-3 planar polarity during Drosophila axis elongation
    Sérgio de Matos Simões
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA
    Dev Cell 19:377-88. 2010
    ..These results demonstrate that Rho-kinase plays an instructive role in planar polarity by targeting Baz/Par-3 and myosin II to complementary cortical domains...
  3. ncbi Early and late periodic patterns of even skipped expression are controlled by distinct regulatory elements that respond to different spatial cues
    T Goto
    Department of Biochemistry, Harvard University, Cambridge, Massachusetts 02138
    Cell 57:413-22. 1989
    ..As a consequence of this two-step regulatory program, eve functions both in the establishment of the periodic pattern of gene expression and in the subsequent specification of parasegmental boundaries...
  4. ncbi Direct activation of Sex-lethal transcription by the Drosophila runt protein
    S G Kramer
    Department of Biochemistry and Cell Biology and the Institute for Cell and Developmental Biology, State University of New York at Stony Brook, Stony Brook, New York 11794 5215, USA
    Development 126:191-200. 1999
    b>Runt functions as a transcriptional regulator in multiple developmental pathways in Drosophila melanogaster. Recent evidence indicates that Runt represses the transcription of several downstream target genes in the segmentation pathway...
  5. pmc Robo-3--mediated repulsive interactions guide R8 axons during Drosophila visual system development
    Kartik S Pappu
    Department of Biological Chemistry, The Howard Hughes Medical Institute, The David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 108:7571-6. 2011
    ..Thus, the transient cell-specific expression of Robo3 plays a crucial role in establishing neural circuits in the Drosophila visual system by selectively regulating pathway choice for posterior-most R8 growth cones...
  6. ncbi Zebra patterns in fly embryos: activation of stripes or repression of interstripes?
    S B Carroll
    Laboratory of Molecular Biology, University of Wisconsin, Madison 53706
    Cell 60:9-16. 1990
    ..Different gap proteins control different subsets of stripes and interstripes. Combinations of gap proteins regulate transcription by binding to far upstream elements that contain different numbers and types of binding sites...
  7. ncbi Patterning of cells in the Drosophila eye by Lozenge, which shares homologous domains with AML1
    A Daga
    Department of Molecular, Cell and Developmental Biology, Molecular Biology Institute, Los Angeles
    Genes Dev 10:1194-205. 1996
    ..is homologous to AML1, a transcription factor associated with human leukemias, and to the Drosophila protein Runt. We show here that Lz plays a crucial role in governing the fate of two groups of cells that are born in a single ..
  8. ncbi Rapid preparation of a panel of polyclonal antibodies to Drosophila segmentation proteins
    D Kosman
    Brookdale Center for Molecular Biology, Box 1126, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Genes Evol 208:290-4. 1998
    ..Antigenicity of the purified recombinant proteins may be increased by precipitation in double-distilled water. The results of using the serums obtained for fluorescent staining of Drosophila embryos are shown...
  9. pmc Pdm and Castor specify late-born motor neuron identity in the NB7-1 lineage
    Ruth Grosskortenhaus
    Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, 97403, USA
    Genes Dev 20:2618-27. 2006
    ....
  10. ncbi The Drosophila segmentation gene runt has an extended cis-regulatory region that is required for vital expression at other stages of development
    B A Butler
    Department of Biochemistry and Cell Biology, State University of New York, Stony Brook 11794
    Mech Dev 39:17-28. 1992
    The Drosophila runt gene functions in several developmental pathways during embryogenesis...
  11. ncbi Concentration-dependent activities of the even-skipped protein in Drosophila embryos
    A S Manoukian
    Banting and Best Department of Medical Research, University of Toronto, C H Best Institute, Ontario, Canada
    Genes Dev 6:1740-51. 1992
    ..of response times appeared to distinguish between genes that were direct [fushi tarazu (ftz), odd-skipped (odd), runt (run), paired, and wingless] and indirect [eve, hairy, and engrailed (en)] targets of Eve...
  12. ncbi Drosophila headlines
    S Cohen
    Howard Hughes Medical Institute, Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
    Trends Genet 7:267-72. 1991
    ..Organization of the cephalic segments uses a mechanism distinct from the familiar bierarchical cascade of segmentation genes that subdivides the trunk of the embryo...
  13. ncbi The Drosophila segmentation gene runt acts as a position-specific numerator element necessary for the uniform expression of the sex-determining gene Sex-lethal
    J B Duffy
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Genes Dev 5:2176-87. 1991
    ..We demonstrate that the X-linked segmentation gene runt is required for this process and has genetic and molecular properties of a numerator element...
  14. ncbi Expression and function of the Drosophila gene runt in early stages of neural development
    J B Duffy
    Department of Biochemistry and Cell Biology, State University of New York, Stony Brook 11794
    Development 113:1223-30. 1991
    The Drosophila gene runt was initially identified on the basis of its role during segmentation...
  15. ncbi Individual stripe regulatory elements in the Drosophila hairy promoter respond to maternal, gap, and pair-rule genes
    G Riddihough
    Imperial Cancer Research Fund, Department of Zoology, University of Oxford, UK
    Genes Dev 5:840-54. 1991
    ..Our results suggest that different but overlapping subsets of gap genes regulate each stripe and that activation and repression are both important in generating the stripe pattern...
  16. ncbi The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system
    M A Kania
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Genes Dev 4:1701-13. 1990
    ..The segmentation gene runt has been classified as one of the primary pair-rule genes because of the pivotal role it plays in regulating the ..
  17. ncbi Spatial control of hairy protein expression during embryogenesis
    K L Hooper
    Zoology Department, Oxford University, UK
    Development 107:489-504. 1989
    ..Our observations suggest that pair-rule striping may be under redundant control, and we discuss possible implications for hierarchical models of pair-rule gene action...
  18. ncbi Isolation of the Drosophila segmentation gene runt and analysis of its expression during embryogenesis
    J P Gergen
    Department of Biochemistry and Molecular Biology, University of Texas System Cancer Center, M D Anderson Hospital and Tumor Institute 77030
    Genes Dev 2:1179-93. 1988
    b>runt is one of the genes required for establishment of the segmented body pattern of the Drosophila embryo. We have isolated DNA sequences containing this gene using P-element transposon tagging...
  19. ncbi Complementary patterns of even-skipped and fushi tarazu expression involve their differential regulation by a common set of segmentation genes in Drosophila
    M Frasch
    Department of Biological Sciences, Fairchild Center, Columbia University, New York, New York 10027
    Genes Dev 1:981-95. 1987
    ....
  20. ncbi The localized requirements for a gene affecting segmentation in Drosophila: analysis of larvae mosaic for runt
    J P Gergen
    Dev Biol 109:321-35. 1985
    The runt gene is required in a developing Drosophila embryo for proper segmentation. Mutant embryos fail to hatch but secrete a larval cuticle in which pattern defects are apparent...
  21. ncbi Repression of Drosophila pair-rule segmentation genes by ectopic expression of tramtrack
    J L Brown
    Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Development 117:45-58. 1993
    ..endogenous ftz gene, as well as significant repression of the pair-rule genes even skipped, odd skipped, hairy and runt. These findings suggest that specific repression by ttk (or by undiscovered repressors) may be more than an ..
  22. pmc Early even-skipped stripes act as morphogenetic gradients at the single cell level to establish engrailed expression
    M Fujioka
    Jefferson Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Development 121:4371-82. 1995
    ..Within this zone, single cell rows express either engrailed, where runt and sloppy-paired are repressed, or wingless, where they are not...
  23. pmc Drosophila homologs of the proto-oncogene product PEBP2/CBF beta regulate the DNA-binding properties of Runt
    G Golling
    Department of Biochemistry and Cell Biology, State University of New York at Stony Brook, 11794 5215, USA
    Mol Cell Biol 16:932-42. 1996
    The Drosophila runt gene is the founding member of the Runt domain family of transcriptional regulators. Mammalian Runt domain genes encode the alpha subunit of the heterometric DNA-binding factor PEBP2/CBF...
  24. ncbi Disperse versus compact elements for the regulation of runt stripes in Drosophila
    M Klingler
    Zoologisches Institut, Luisenstrasse 14, Munich, D 80333, Germany
    Dev Biol 177:73-84. 1996
    ..Here we describe the cis-regulatory region of the runt gene...
  25. ncbi The Dichaete gene of Drosophila melanogaster encodes a SOX-domain protein required for embryonic segmentation
    S R Russell
    Department of Genetics, University of Cambridge, UK
    Development 122:3669-76. 1996
    ..genes and is required for the appropriate expression of the primary pair-rule genes even skipped, hairy and runt. The molecular nature of Dichaete and its expression pattern during early embryogenesis suggest that the gene plays ..
  26. ncbi Vive la différence: males vs females in flies vs worms
    T W Cline
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3204, USA
    Annu Rev Genet 30:637-702. 1996
    ..Although no overlap has been found among the molecules used by flies and worms to achieve sex determination, striking similarities have been found in the genetic strategies used by these two species to differentiate their sexes...
  27. pmc Groucho-dependent and -independent repression activities of Runt domain proteins
    B D Aronson
    Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, State University of New York at Stony Brook, 11794 5215, USA
    Mol Cell Biol 17:5581-7. 1997
    b>Runt domain proteins are transcriptional regulators that specify cell fates for processes extending from pattern formation in insects to leukemogenesis in humans...
  28. ncbi Segmentation: painting stripes from flies to vertebrates
    L Pick
    Brookdale Center for Developmental and Molecular Biology, Mt Sinai School of Medicine, New York, NY 10029, USA
    Dev Genet 23:1-10. 1998
  29. ncbi Structure and evolution of a pair-rule interaction element: runt regulatory sequences in D. melanogaster and D. virilis
    C Wolff
    Zoologisches Institut der Universität München, Germany
    Mech Dev 80:87-99. 1999
    ..Previously, we described a pair-rule input region of the runt gene...
  30. pmc Analysis of an even-skipped rescue transgene reveals both composite and discrete neuronal and early blastoderm enhancers, and multi-stripe positioning by gap gene repressor gradients
    M Fujioka
    Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Development 126:2527-38. 1999
    ..Additionally, a strong pairing-sensitive repression element was localized to the 3' end of the locus, but was not found to contribute to efficient functional rescue...
  31. ncbi The even-skipped locus is contained in a 16-kb chromatin domain
    C Sackerson
    Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107, USA
    Dev Biol 211:39-52. 1999
    ..4) Expression in different sites in the central nervous system is driven by separable elements widely dispersed throughout 8 kb 3' of the gene...
  32. ncbi Differential interactions between Brother proteins and Runt domain proteins in the Drosophila embryo and eye
    L H Li
    Department of Biochemistry and Cell Biology and the Institute for Cell and Developmental Biology, SUNY at Stony Brook, Stony Brook, NY 11794 5215, USA
    Development 126:3313-22. 1999
    Brother and Big brother were isolated as Runt-interacting proteins and are homologous to CBF(beta), which interacts with the mammalian CBF(alpha) Runt-domain proteins...
  33. pmc Quantitative analysis of gene function in the Drosophila embryo
    W D Tracey
    Department of Biochemistry and Cell Biology and the Institute for Cell and Developmental Biology, State University of New York, Stony Brook, New York 11794 5215, USA
    Genetics 154:273-84. 2000
    ..Analysis of the response to overexpression of runt provides evidence that this pair-rule segmentation gene has a direct role in repressing transcription of the ..
  34. ncbi Sloppy paired acts as the downstream target of wingless in the Drosophila CNS and interaction between sloppy paired and gooseberry inhibits sloppy paired during neurogenesis
    K M Bhat
    Department of Cell Biology, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA
    Development 127:655-65. 2000
    ..This mechanism appears to be responsible for specifying NB5-3 identity to a row 5 neuroblast and preventing Wg from specifying NB4-2 identity to that cell...
  35. ncbi Redundant function of Runt Domain binding partners, Big brother and Brother, during Drosophila development
    J S Kaminker
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Development 128:2639-48. 2001
    ..The alpha-subunit is encoded by members of the Runt Domain family of proteins and the beta-subunit is encoded by the CBF beta gene...
  36. pmc Genome-wide analysis of clustered Dorsal binding sites identifies putative target genes in the Drosophila embryo
    Michele Markstein
    Department of Molecular and Cell Biology, Division of Genetics and Development, 401 Barker Hall, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 99:763-8. 2002
    ..These results suggest that bioinformatics can be used to identify novel target genes and associated regulatory DNAs in a gene network...
  37. pmc Extraction of functional binding sites from unique regulatory regions: the Drosophila early developmental enhancers
    Dmitri A Papatsenko
    Department of Biology, New York University, New York, NY 10003 6688, USA
    Genome Res 12:470-81. 2002
    ..We also discuss the definition of true binding sites and the possible biological principles that govern patterning of regulatory regions and the distribution of transcriptional signals...
  38. ncbi Yan regulates Lozenge during Drosophila eye development
    Kristina Jackson Behan
    Department of Biological Sciences, Carnegie Mellon University, Pittsburg, PA 15213, USA
    Dev Genes Evol 212:267-76. 2002
    ..We propose that upregulated Lozenge acts as a cofactor to alter Pointed affinity, by a mechanism that is recapitulated in mammalian development...
  39. ncbi Control of photoreceptor axon target choice by transcriptional repression of Runt
    Joshua S Kaminker
    Department of Molecular, Cell, and Developmental Biology, Molecular Biology Institute, University of California, Los Angeles, California 90095, USA
    Nat Neurosci 5:746-50. 2002
    ..The transcription factor Runt (Run) is normally expressed in the two inner R cells (R7 and R8) that project their axons to the medulla...
  40. ncbi Axon targeting in the Drosophila visual system
    Timothy D Tayler
    Department of Biology, 68 230 Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Curr Opin Neurobiol 13:90-5. 2003
    ..of the R1-R6 subset of photoreceptor axons have been found to be influenced by the nuclear factors Brakeless and Runt, and target selection decisions of the R7 subset of axons have been found to require the cell-surface proteins ..
  41. pmc The evolution of Runx genes I. A comparative study of sequences from phylogenetically diverse model organisms
    Jessica Rennert
    Stowers Institute for Medical Research, 1000 E, 50th Street, Kansas City, MO 64110, USA
    BMC Evol Biol 3:4. 2003
    Runx genes encode proteins defined by the highly conserved Runt DNA-binding domain. Studies of Runx genes and proteins in model organisms indicate that they are key transcriptional regulators of animal development...
  42. ncbi A DNA-binding-independent pathway of repression by the Drosophila Runt protein
    Christine J Vander Zwan
    Department of Biochemistry and Cell Biology and the Center for Developmental Genetics, State University of New York at Stony Brook, Stony Brook, NY 11794 5140, USA
    Blood Cells Mol Dis 30:207-22. 2003
    ..analysis of gene function in the Drosophila embryo, we have discovered a DNA-binding-independent activity of Runt, the founding member of the RUNX family of transcriptional regulators...
  43. ncbi Ftz modulates Runt-dependent activation and repression of segment-polarity gene transcription
    Deborah Swantek
    Department of Biochemistry and Cell Biology and the Center for Developmental Genetics, State University of New York at Stony Brook, Stony Brook, NY 11794 5140, USA
    Development 131:2281-90. 2004
    ..for quantitative manipulation of expression levels to probe the role of the primary pair-rule transcription factor Runt in segment-polarity gene regulation...
  44. pmc The evolution of the Drosophila sex-determination pathway
    Andrew Pomiankowski
    Department of Biology, University College, London NW1 2HE, United Kingdom
    Genetics 166:1761-73. 2004
    ..Our hypothesis is built on the available data from Drosophila and other insect species, and we point out where it is amenable to further experimental and comparative tests...
  45. ncbi Regulation of R7 and R8 differentiation by the spalt genes
    Pedro M Domingos
    Howard Hughes Medical Institute, Strang Laboratory of Cancer Research, The Rockefeller University, New York, NY 10021, USA
    Dev Biol 273:121-33. 2004
    ..5, and runt) is lost in spalt mutant clones...
  46. pmc Transcriptional control in the segmentation gene network of Drosophila
    Mark D Schroeder
    Laboratory of Developmental Neurogenetics, Rockefeller University, New York, New York, USA
    PLoS Biol 2:E271. 2004
    ..The study demonstrates that computational methods are a powerful complement to experimental approaches in the analysis of transcription networks...
  47. ncbi Locus-specific requirements for Spt5 in transcriptional activation and repression in Drosophila
    Barbara H Jennings
    Developmental Genetics Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Curr Biol 14:1680-4. 2004
    ..expression of gap genes remains wild-type, but striped patterning of the primary pair-rule genes even-skipped and runt is disrupted...
  48. ncbi Alternative splicing removes an Ets interaction domain from Lozenge during Drosophila eye development
    Kristina Jackson Behan
    University of West Florida, Pensacola 32514, USA
    Dev Genes Evol 215:423-35. 2005
    ..The runt-homology domain responsible for DNA binding and also the C-terminus are both nearly identical between the two ..
  49. pmc Unmasking activation of the zygotic genome using chromosomal deletions in the Drosophila embryo
    Stefano de Renzis
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, New Jersey, United States of America
    PLoS Biol 5:e117. 2007
    ..We propose that this regulatory mode links morphogen gradients with temporal regulation during the maternal-to-zygotic transition...
  50. pmc Cotranscriptional recruitment of the dosage compensation complex to X-linked target genes
    Jop Kind
    European Molecular Biology Laboratory, Heidelberg 69117, Germany
    Genes Dev 21:2030-40. 2007
    ..We propose a model of dynamic MSL complex binding to active genes based on exposed DNA target elements...
  51. pmc Characterization of the Drosophila segment determination morphome
    Svetlana Surkova
    Department of Computational Biology, Center for Advanced Studies, St Petersburg State Polytechnical University, 29 Polytehnicheskaya Street, St Petersburg, 195251, Russia
    Dev Biol 313:844-62. 2008
    ..As the first quantitatively characterized morphogenetic field, this system and its behavior constitute an extraordinarily rich set of materials for the study of canalization and embryonic regulation at the molecular level...
  52. doi Genome-wide analysis reveals MOF as a key regulator of dosage compensation and gene expression in Drosophila
    Jop Kind
    Gene Expression Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Cell 133:813-28. 2008
    ..Therefore, MOF is not only involved in the onset of dosage compensation, but also acts as a regulator of gene expression in the Drosophila genome...
  53. doi Conserved cluster organization of insect Runx genes
    Riyue Bao
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    Dev Genes Evol 218:567-74. 2008
    ..The Drosophila genome contains four Runx genes, two of which are well studied (runt and lozenge) and two of which have not been explored in depth yet (CG42267 and CG34145)...
  54. pmc Pipeline for acquisition of quantitative data on segmentation gene expression from confocal images
    Svetlana Surkova
    Department of Computational Biology, Center for Advanced Studies, St Petersburg State Polytechnical University, St Petersburg, Russia
    Fly (Austin) 2:58-66. 2008
    ..5-minute resolution in time, as well as to construct a spatiotemporal atlas of segmentation gene expression. Each data pipeline step can be easily adapted to process a wide range of images of gene expression patterns...
  55. pmc FlyEx, the quantitative atlas on segmentation gene expression at cellular resolution
    Andrei Pisarev
    Department of Computational Biology, St Petersburg State Polytechnical University, St Petersburg 195251, Russia
    Nucleic Acids Res 37:D560-6. 2009
    ..5 h of development. FlyEx supports the data downloads and construction of personal reference datasets, that makes it possible to more effectively use and analyze data...
  56. pmc Photoreceptor neurons find new synaptic targets when misdirected by overexpressing runt in Drosophila
    Tara N Edwards
    Department of Biology, Life Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada
    J Neurosci 29:828-41. 2009
    ..melanogaster, we used the yeast GAL4/UAS system to drive exogenous expression of the transcription factor Runt in subsets of photoreceptors, resulting in aberrant axonal pathfinding and, ultimately, incorrect targeting of R1-..
  57. pmc Developmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regions
    Stewart MacArthur
    Genomics Division, Lawrence Berkeley National Laboratory, Cyclotron Road MS 84 181, Berkeley, CA 94720, USA
    Genome Biol 10:R80. 2009
    ....
  58. pmc Non-additive interactions involving two distinct elements mediate sloppy-paired regulation by pair-rule transcription factors
    Lisa Prazak
    Department of Biochemistry and Cell Biology and the Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794 5215, USA
    Dev Biol 344:1048-59. 2010
    ..expresses only even-numbered stripes and mediates repression by Even-skipped (Eve) as well as by the combination of Runt and Fushi-tarazu (Ftz)...
  59. pmc Quantitative models of the mechanisms that control genome-wide patterns of transcription factor binding during early Drosophila development
    Tommy Kaplan
    Department of Molecular and Cell Biology, California Institute of Quantitative Biosciences, University of California Berkeley, Berkeley, California, United States of America
    PLoS Genet 7:e1001290. 2011
    ....
  60. pmc Drosophila hedgehog signaling and engrailed-runt mutual repression direct midline glia to alternative ensheathing and non-ensheathing fates
    JOSEPH D WATSON
    Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Development 138:1285-95. 2011
    ..Two transcription factor genes, runt and engrailed, play important roles in AMG and PMG development...
  61. pmc How to make stripes: deciphering the transition from non-periodic to periodic patterns in Drosophila segmentation
    Mark D Schroeder
    Laboratory of Developmental Neurogenetics, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Development 138:3067-78. 2011
    ..We find that runt (run), fushi tarazu (ftz) and odd skipped (odd) establish most of their pattern through stripe-specific elements, ..
  62. doi A statistical fat-tail test of predicting regulatory regions in the Drosophila genome
    Jian Jun Shu
    School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
    Comput Biol Med 42:935-41. 2012
    ..These two fatness coefficients may serve as valuable filtering indexes to predict CRMs experimentally...
  63. pmc Rearrangements of 2.5 kilobases of noncoding DNA from the Drosophila even-skipped locus define predictive rules of genomic cis-regulatory logic
    Ah Ram Kim
    Department of Ecology and Evolution, Chicago Center for Systems Biology, University of Chicago, Chicago, Illinois, USA
    PLoS Genet 9:e1003243. 2013
    ....
  64. doi Evaluating thermodynamic models of enhancer activity on cellular resolution gene expression data
    Abul Hassan Samee
    Department of Computer Science, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Methods 62:79-90. 2013
    ..Finally, we show how fitting quantitative models on data sets comprising a handful of enhancers, as reported in earlier work, may lead to unreliable models...
  65. pmc Precise developmental gene expression arises from globally stochastic transcriptional activity
    Shawn C Little
    Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA
    Cell 154:789-800. 2013
    ..The findings shed light on how the apparent paradox between stochastic transcription and developmental precision is resolved...
  66. ncbi Gap gene properties of the pair-rule gene runt during Drosophila segmentation
    C Tsai
    Department of Biochemistry and Cell Biology, State University of New York at Stony Brook 11794 5215
    Development 120:1671-83. 1994
    The Drosophila Runt protein is a member of a new family of transcriptional regulators that have important roles in processes extending from pattern formation in insect embryos to leukemogenesis in humans...
  67. ncbi Runt determines cell fates in the Drosophila embryonic CNS
    E L Dormand
    Wellcome CRC Institute, University of Cambridge, Cambridge, UK
    Development 125:1659-67. 1998
    The segmentation gene, runt, is expressed by a subset of the 30 neuroblasts that give rise to each neuromere of the Drosophila embryo. Runt activity in the neuroblasts is necessary for expression of even-skipped in the EL neurons...
  68. ncbi The segmentation gene runt is needed to activate Sex-lethal, a gene that controls sex determination and dosage compensation in Drosophila
    M Torres
    Centro de Investigaciones Biologicas, Madrid, Spain
    Genet Res 59:189-98. 1992
    ..Here we find that the X-linked segmentation gene runt plays a role in this process...
  69. ncbi deadpan, an essential pan-neural gene encoding an HLH protein, acts as a denominator in Drosophila sex determination
    S Younger-Shepherd
    Howard Hughes Medical Institute, University of California, San Francisco 94143
    Cell 70:911-22. 1992
    ....
  70. ncbi Dynamic changes in the functions of Odd-skipped during early Drosophila embryogenesis
    B Saulier-Le Drean
    Banting and Best Department of Medical Research, Charles H Best Institute, University of Toronto, Toronto, Ontario, Canada, M5G 1L6
    Development 125:4851-61. 1998
    ..Based on these results, and the segmental phenotypes generated by ectopic Odd, we suggest a number of new roles for Odd in the patterning of embryonic segments. These include gap-, pair-rule- and segment polarity-type functions...
  71. pmc Distance preferences in the arrangement of binding motifs and hierarchical levels in organization of transcription regulatory information
    Vsevolod J Makeev
    Scientific Center Genetika, Moscow 113545, Russia
    Nucleic Acids Res 31:6016-26. 2003
    ..We discuss the role of the hierarchy in understanding transcriptional regulation and in detection of transcription regulatory regions in genomes...
  72. pmc Small bristles, the Drosophila ortholog of NXF-1, is essential for mRNA export throughout development
    G S Wilkie
    Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Scotland, United Kingdom
    RNA 7:1781-92. 2001
    ..We conclude that NXF-1 is an essential ubiquitous export factor for all mRNAs throughout development in higher eukaryotes...
  73. ncbi Groucho-dependent repression by sloppy-paired 1 differentially positions anterior pair-rule stripes in the Drosophila embryo
    Luiz P Andrioli
    Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Dev Biol 276:541-51. 2004
    ..The Slp1 protein contains a protein motif (EH1) which mediates binding to the transcriptional corepressor Groucho (Gro). We show that this domain is required for Slp1-mediated repression in vivo...
  74. doi Gene and epigene networks: two levels in organizing the hereditary system
    R N Tchuraev
    Institute of Biology, Ufa Research Center, Russian Academy of Sciences, 69 Prospect Oktyabrya, Ufa 450054, Russia
    J Theor Biol 259:659-69. 2009
    ..In addition, the experimental results are given on construction an artificial epigene...
  75. doi Huckebein is part of a combinatorial repression code in the anterior blastoderm
    Luiz Paulo Andrioli
    Departamento de Genética e Biologia Evolutiva, Instituto de Biociencias, Universidade Sao Paulo, R do Matão, 277, Cidade Universitaria, 05508 000, Sao Paulo, SP, Brazil
    Dev Biol 361:177-85. 2012
    ..mechanism responsible for repressing the cis-regulatory modules (CRMs) of hairy (h), even-skipped (eve), runt (run), and fushi-tarazu (ftz) anterior-most stripes...
  76. doi Drosophila Polycomb complexes restrict neuroblast competence to generate motoneurons
    Johnny J Touma
    School of Natural Sciences, University of California Merced, CA 95343, USA
    Development 139:657-66. 2012
    ..These findings support a model in which PRCs establish motoneuron-specific competence windows in neuroblasts that transition from motoneuron to interneuron production...
  77. ncbi Distribution and function of the lethal of scute gene product during early neurogenesis in Drosophila
    M D Martin-Bermudo
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Spain
    Development 113:445-54. 1991
    ..However, our study in l'sc mutants of the expression of fushi tarazu, engrailed, and even-skipped, used as markers of neuronal identity, has not provided evidence to support this hypothesis...
  78. ncbi Synthetic oligonucleotides recreate Drosophila fushi tarazu zebra-stripe expression
    J Topol
    Division of Chemistry, California Institute of Technology, Pasadena 91125
    Genes Dev 5:855-67. 1991
    ..The reconstructed promoter system presented provides an effective means of studying molecular mechanisms governing spatially restricted transcription in the early embryo...
  79. ncbi Regulation and function of the Drosophila segmentation gene fushi tarazu
    Y Hiromi
    Cell 50:963-74. 1987
    ..The upstream element can also confer expression patterns similar to that of the homeotic gene Antennapedia, suggesting that a similar element may play a role in the activation of Antennapedia...
  80. ncbi Dosage requirements for runt in the segmentation of Drosophila embryos
    J P Gergen
    Cell 45:289-99. 1986
    The runt gene is required in a Drosophila embryo for normal segmentation. We investigate this requirement by analyzing runt mutations of varying strength and by manipulating wild-type gene dosage...
  81. ncbi Localization of the genes shaking-B, small optic lobes, sluggish-A, stoned and stress-sensitive-C to a well-defined region on the X-chromosome of Drosophila melanogaster
    G L Miklos
    J Neurogenet 4:1-19. 1987
    ....
  82. pmc PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene
    E Ogawa
    Department of Viral Oncology, Kyoto University, Japan
    Proc Natl Acad Sci U S A 90:6859-63. 1993
    ..The products of the cDNAs are highly homologous to that of Drosophila segmentation gene runt (run) for an N-proximal 128-amino acid region showing 66% identity...
  83. ncbi Neuroblast specification and formation regulated by wingless in the Drosophila CNS
    Q Chu-LaGraff
    Department of Cell and Structural Biology, University of Illinois, Urbana 61801
    Science 261:1594-7. 1993
    ..Loss of wingless results in the absence or duplication of identified neuroblasts, highlighting its role in generating neuroblast diversity in the CNS...
  84. ncbi Trans- and cis-acting requirements for blastodermal expression of the head gap gene buttonhead
    E A Wimmer
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Mech Dev 53:235-45. 1995
    ..Finally, the terminal system takes part in the regulation of btd head stripe expression by enhancing activation at low levels of activity and repression at high levels of activity...
  85. ncbi Nucleotide compositional constraints on genomes generate alanine-, glycine-, and proline-rich structures in transcription factors
    Y Nakachi
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Japan
    Mol Biol Evol 14:1042-9. 1997
    ..Furthermore, reptile class III POU sequences revealed no evolutionary directionality increasing the GC contents from cold- to warm-blooded vertebrates...
  86. ncbi The function of hairy-related bHLH repressor proteins in cell fate decisions
    A Fisher
    Department of Cell Biology and Anatomy, Cornell University Medical College, New York, New York, USA
    Bioessays 20:298-306. 1998
    ..This general function in cell fate specification has been conserved from Drosophila to vertebrates and has implications for human disease pathogenesis...
  87. pmc From head to toes: the multiple facets of Sox proteins
    M Wegner
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Martinistrasse 52, D 20246 Hamburg, Germany
    Nucleic Acids Res 27:1409-20. 1999
    ..Sox proteins perform their function in a complex interplay with other transcription factors in a manner highly dependent on cell type and promoter context. They exhibit a remarkable crosstalk and functional redundancy among each other...
  88. ncbi JAKs and STATs in invertebrate model organisms
    C R Dearolf
    Department of Pediatrics, Massachusetts General Hospital, Boston, USA
    Cell Mol Life Sci 55:1578-84. 1999
    ..Future research utilizing these organisms should continue to provide insights into the roles and regulation of these proteins and their signaling pathways...
  89. pmc Pan-neural Prospero terminates cell proliferation during Drosophila neurogenesis
    L Li
    Department of Molecular Genetics, Ohio State University, Columbus, Ohio 43210 USA
    Genes Dev 14:147-51. 2000
    ..pros activity, hence, provides a critical regulatory link between neuronal lineage development and transcriptional regulation of cell cycle regulatory genes...
  90. ncbi The roles of the Drosophila JAK/STAT pathway
    M P Zeidler
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts, MA 02115, USA
    Oncogene 19:2598-606. 2000
    ..Oncogene (2000)...
  91. ncbi Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors
    M S Halfon
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Cell 103:63-74. 2000
    ..The integration of Pointed with the combinatorial effects of dTCF, Mad, Twist, and Tinman determines inductive Ras signaling specificity in muscle and heart development...
  92. ncbi Linking global histone acetylation to the transcription enhancement of X-chromosomal genes in Drosophila males
    E R Smith
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 276:31483-6. 2001
    ..This study represents the first biochemical interpretation of the very large body of cytological observations on the chromosomal distribution of the MSL complex...
  93. ncbi CtBP, an unconventional transcriptional corepressor in development and oncogenesis
    G Chinnadurai
    Institute for Molecular Virology, Saint Louis University School of Medicine, 3681 Park Avenue, St Louis, MO 63110, USA
    Mol Cell 9:213-24. 2002
    ..CtBPs play important roles during development and oncogenesis. In this review, their unusual properties, the mechanisms of transcriptional repression, regulation, and their biological functions are discussed...
  94. ncbi Segmentation
    Diethard Tautz
    Institut für Genetik der Universität zu Köln, Weyertal 121, 50931, Germany
    Dev Cell 7:301-12. 2004
    ..An old concept of comparative anatomy, the enterocoele theory, is compatible with a single origin of segmentation mechanisms and could therefore provide a conceptual framework for assessing these molecular similarities...
  95. pmc 3D analysis of founder cell and fusion competent myoblast arrangements outlines a new model of myoblast fusion
    Karen Beckett
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Dev Biol 309:113-25. 2007
    ..5 h. Altogether, our data have led us to propose a new model of myoblast fusion where the frequency of myoblast fusion events may be influenced by the spatial arrangements of FCs and FCMs...
  96. pmc Egalitarian is a selective RNA-binding protein linking mRNA localization signals to the dynein motor
    Martin Dienstbier
    Cell Biology Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Genes Dev 23:1546-58. 2009
    ....
  97. ncbi Sex determination and differentiation in invertebrates: Drosophila and Caenorhabditis elegans
    M McKeown
    Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92186
    Curr Opin Cell Biol 4:948-54. 1992
    ..We are now gaining an understanding of the molecular mechanisms governing the largely post-transcriptional regulation of the intermediate steps in these cascades...
  98. ncbi Molecular analysis of the lethal(1)B214 region at the base of the X chromosome of Drosophila melanogaster
    R J Russell
    CSIRO Division of Entomology, Canberra, A C T, Australia
    Chromosoma 101:456-66. 1992
    ....
  99. ncbi The shaker and shaking-B genes specify elements in the processing of gustatory information in Drosophila melanogaster
    R Balakrishnan
    Molecular Biology Unit, Tata Institute of Fundamental Research, Bombay, India
    J Exp Biol 157:161-81. 1991
    ..Mutants at this locus show increased thresholds for detection of sucrose and fructose and lack the attraction response to 0.1 mol l-1 sodium chloride that is exhibited by the wild-type fly...
  100. ncbi Modeling the Drosophila pair-rule pattern by reaction-diffusion: gap input and pattern control in a 4-morphogen system
    T C Lacalli
    Biology Department, University of Saskatchewan, Saskatoon, Canada
    J Theor Biol 144:171-94. 1990
    ..Possible candidates include the primary pair-rule genes, hairy and runt. The conditions under which regular stripes are generated by the model are then examined, with emphasis on the way ..

Research Grants11

  1. Signaling Mechanisms of the Drosophila JAK/STAT Pathway
    Hong Luo; Fiscal Year: 2003
    ..abstract_text> ..
  2. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
    ....
  3. Technique to Obtain Intra-Locus Deletions in Eukaryotes
    Charles Dearolf; Fiscal Year: 2003
    ..However, this research could have a very high impact, providing a method to generate deletion mutations in any gene or chromosomal region for a wide range of organisms. ..
  4. A Novel Mutagenesis Technology for Drosophila
    Charles Dearolf; Fiscal Year: 2003
    ..It will also allow the recovery of mutations without any selection based upon phenotype. Finally, this technology should ultimately be applicable to other model genetic organisms as well as to Drosophila. ..
  5. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
    ....
  6. BH3-only protein BNIP3 in tumor progression
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2006
    ..Our results may also provide the experimental support to suggest that BNIP3 may be a new prognostic marker for human cancer. [unreadable] [unreadable]..
  7. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  8. Apoptosis Signaling: BH3 to BH123 Proteins
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2008
    ..The knowledge gained would be valuable in modulating the activity of BAX in cancer and in degenerative diseases. ..
  9. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
    ..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
  10. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  11. Molecular and genetic analysis of sanpodo
    James B Skeath; Fiscal Year: 2010
    ..Such insight should help us understand the etiology of diseases in which this process is de-regulated and design new methods to treat these diseases. ..