Genomes and Genes
Gene Symbol: RpL32
Description: Ribosomal protein L32
Alias: 143250_at, BcDNA:RH03940, CG7939, Dmel\CG7939, L32, M(3)99D, RP-49, RP49, RPL32, Rp-49, Rp49, Rp49/RpL32, Rpl32, bs30a02.y1, rp49, rp49/RpL32, rpl32, CG7939 gene product from transcript CG7939-RB, CG7939-PA, CG7939-PB, CG7939-PC, CG7939-PD, Minute(3)99D, RpL32-PA, RpL32-PB, RpL32-PC, RpL32-PD, r-protein 49, ribosomal protein 49, ribosomal protein 49/L32, ribosomal protein L32
Species: fruit fly
- Molecular and chromosomal phylogeny in the obscura group of Drosophila inferred from sequences of the rp49 gene regionS Ramos-Onsins
Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Spain
Mol Phylogenet Evol 9:33-41. 1998A region of approximately 1.6 kb encompassing the ribosomal protein 49 gene (rp49) has been sequenced and compared in nine species of the obscura group of Drosophila: four species belonging to the obscura subgroup, three to the ..
- Molecular evolution of the ocnus and janus genes in the Drosophila melanogaster species subgroupJ Parsch
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138 2020, USA
Mol Biol Evol 18:801-11. 2001..These results are consistent with previous studies that have detected an increased rate of evolution in genes with reproductive function...
- Drosophila PTB promotes formation of high-order RNP particles and represses oskar translationFlorence Besse
Developmental Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
Genes Dev 23:195-207. 2009..Thus, PTB is a key structural component of oskar RNP complexes that dually controls formation of high-order RNP particles and translational silencing...
- Myosin-V regulates oskar mRNA localization in the Drosophila oocyteJana Krauss
Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Spemannstrasse 35, 72076 Tubingen, Germany
Curr Biol 19:1058-63. 2009..Our findings reveal that a balance of microtubule- and actin-based motor activities regulates oskar mRNA localization in the Drosophila oocyte...
- Role of histone deacetylases in gene regulation at nuclear laminaBeatrice C Milon
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA
PLoS ONE 7:e49692. 2012..These findings demonstrate the manifold and central involvement of class I HDACs in regulation of lamina-associated genes, illuminating a mechanism by which these enzymes can orchestrate normal and pathological development...
- Studies on the role of NonA in mRNA biogenesisNatalia Kozlova
Department of Molecular Biology and Functional Genomics, Stockholm University, SE 10691 Stockholm, Sweden
Exp Cell Res 312:2619-30. 2006..Our data suggest that NonA facilitates the intranuclear mobility of mRNP particles...
- CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1Bartlomiej Bartkowiak
Department of Biochemistry, Duke Center for RNA Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Genes Dev 24:2303-16. 2010..Finally, we show that siRNA knockdown of hCDK12 in HeLa cells results in alterations in the CTD phosphorylation state. Our findings demonstrate that metazoan CDK12 and CDK13 are CTD kinases, and that CDK12 is orthologous to yeast Ctk1...
- Adult circadian behavior in Drosophila requires developmental expression of cycle, but not periodTadahiro Goda
Department of Biology, University of Virginia, Charlottesville, VA, USA
PLoS Genet 7:e1002167. 2011..Given the conservation of clock genes and circuits among animals, this study provides a rationale for investigating a possible similar developmental role of the homologous mammalian CLOCK/BMAL1 complex...
- MAPK/ERK signaling regulates insulin sensitivity to control glucose metabolism in DrosophilaWei Zhang
Institute of Molecular and Cell Biology, Singapore, Singapore
PLoS Genet 7:e1002429. 2011..The MAPK/ERK pathway acts via the ETS-1 transcription factor Pointed. This mechanism permits physiological adjustment of insulin sensitivity and subsequent maintenance of circulating glucose at appropriate levels...
- Uracil-containing DNA in Drosophila: stability, stage-specific accumulation, and developmental involvementVillo Muha
Institute of Enzymology, Research Center for Natural Sciences, Hungarian Academy of Science, Budapest, Hungary
PLoS Genet 8:e1002738. 2012..Importantly, we also show lack of the UNG gene in all available genomes of other Holometabola insects, indicating a potentially general tolerance and developmental role of uracil-DNA in this evolutionary clade...
- Phenotypic Plasticity through Transcriptional Regulation of the Evolutionary Hotspot Gene tan in Drosophila melanogasterJean Michel Gibert
Sorbonne Universités, Université Pierre et Marie Curie UPMC, CNRS, Institut de Biologie Paris Seine IBPS, Laboratoire de Biologie du Developpement, Equipe Contrôle épigénétique de l homéostasie et de la plasticité du développement, Paris, France
PLoS Genet 12:e1006218. 2016..Sensitivity of t expression to environmental conditions might therefore give more substrate for selection, explaining why this gene has frequently been involved in evolution of pigmentation. ..
- Mechanism of silver nanoparticles action on insect pigmentation reveals intervention of copper homeostasisNajealicka Armstrong
Biology Department, Howard University, Washington, DC, USA
PLoS ONE 8:e53186. 2013..Finally, we claim that Drosophila, an established genetic model system, can be well utilized for further understanding of the biological effects of nanoparticles...
- Fluorescent protein tagging confirms the presence of ribosomal proteins at Drosophila polytene chromosomesKushal Nivriti Rugjee
University of Birmingham, School of Biosciences, UK
Peerj 1:e15. 2013..we have generated several transgenic flies expressing RPs (RpS2, RpS5a, RpS9, RpS11, RpS13, RpS18, RpL8, RpL11, RpL32, and RpL36) tagged with either green or red fluorescent protein...
- Visualization of the joining of ribosomal subunits reveals the presence of 80S ribosomes in the nucleusKhalid Al-Jubran
RNA 19:1669-83. 2013..Furthermore, we detected rapid puromycin incorporation in the nucleolus and at transcription sites, providing an independent indication of functional 80S in the nucleolus and 80S association with nascent transcripts. ..
- Introgression in the Drosophila subobscura--D. Madeirensis sister species: evidence of gene flow in nuclear genes despite mitochondrial differentiationDanielle K Herrig
Interdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA, 52242
Evolution 68:705-19. 2014..Contrary to other observations in Drosophila, the mitochondrial genome appears resilient to gene flow in the presence of nuclear exchange. ..
- The EJC binding and dissociating activity of PYM is regulated in DrosophilaSanjay Ghosh
European Molecular Biology Laboratory, Heidelberg, Germany
PLoS Genet 10:e1004455. 2014..This, together with the fact that the EJC-disassembly activity of DmPYM is regulated, implicates PYM as an effector of EJC homeostasis in vivo. ..
- The causes and consequences of changes in virulence following pathogen host shiftsBen Longdon
Department of Genetics, University of Cambridge, Cambridge, United Kingdom
PLoS Pathog 11:e1004728. 2015..High levels of virulence are associated with high viral loads, and this may determine the transmission rate of the virus...
- Transcriptional inhibition of the Catalase gene in phosphine-induced oxidative stress in Drosophila melanogasterTao Liu
Chinese Academy of Inspection and Quarantine, NO 241, Huixinxijie, Chaoyang District, Beijing 100029, China
Pestic Biochem Physiol 124:1-7. 2015..These results confirmed that PH3 induces oxidative stress and targets CAT by downregulating its encoding gene in Drosophila. Our results provide new insight into the signal transduction mechanism between PH3 and its target genes...
- The Differences Between Cis- and Trans-Gene Inactivation Caused by Heterochromatin in DrosophilaYuriy A Abramov
Department of Molecular Genetics of the Cell, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow 123182, Russia
Genetics 202:93-106. 2016..We demonstrate that trans-inactivation is followed by de novo HP1a accumulation in the affected transgene; trans-inactivation is specifically favored by the chromatin remodeler SAYP and prevented by Argonaute AGO2. ..
- On the possible role of tRNA base modifications in the evolution of codon usage: queuosine and DrosophilaYlenia Chiari
Department of Ecology and Evolutionary Biology, Yale University, 21 Sachem St, New Haven, CT 06520 8106, USA
J Mol Evol 70:339-45. 2010..willistoni is in young females producing eggs. Because tRNAs laid down in eggs persist through the early stages of development, this implies that Q modification occurs earlier in development in D. willistoni than in other Drosophila...
- In situ visualization of gene expression using polymer-coated quantum-dot-DNA conjugatesYoungseon Choi
Nano Bio Chemistry Group, Institut Pasteur Korea, Seongnam, South Korea
Small 5:2085-91. 2009..Importantly, multiplex FISH of Ribosomal protein 49 and Actin 5C using green and red QD-DNA conjugates allows the observation of cellular distribution of the ..
- Evaluation of potential reference genes for reverse transcription-qPCR studies of physiological responses in Drosophila melanogasterFleur Ponton
School of Biological Sciences, Heydon Laurence Building A08, The University of Sydney, NSW 2006, Australia
J Insect Physiol 57:840-50. 2011..We analyzed the expression levels of seven candidate reference genes (Actin, EF1, Mnf, Rps20, Rpl32, Tubulin and 18S) in flies that were injured, heat-stressed, or fed different diets...
- Analysis of a shift in codon usage in DrosophilaJeffrey R Powell
Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520 8106, USA
J Mol Evol 57:S214-25. 2003..However, we do not argue that this shift was adaptive in nature, rather it may be an example of a "frozen accident."..
- Decreased expression of the GABAA receptor in fragile X syndromeCharlotte D'Hulst
Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
Brain Res 1121:238-45. 2006....
- Getting real with real-time qPCR: a case study of reference gene selection for morphological variation in Drosophila melanogaster wingsBruna P Matta
Laboratório de Evolução de Caracteres Complexos, Departamento de Genetica, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rua Professor Rodolpho Paulo Rocco, s n Prédio do CCS, Bloco A, sala A2 075 Cidade Universitária, Rio de Janeiro, 21941 617, RJ, Brazil
Dev Genes Evol 221:49-57. 2011..Overall, we identified and validated a pair of genes (RpL32 and Tbp) as being stably expressed in both experimental comparisons...
- Identification and characterization of a juvenile hormone response element and its binding proteinsYiping Li
Department of Entomology, University of Kentucky, Lexington, KY 40546, USA
J Biol Chem 282:37605-17. 2007....
- Fcp1 dephosphorylation of the RNA polymerase II C-terminal domain is required for efficient transcription of heat shock genesNicholas J Fuda
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA
Mol Cell Biol 32:3428-37. 2012..Our results indicate that Fcp1 is required to maintain the pool of initiation-competent unphosphorylated Pol II, and this function is particularly important for the highly transcribed heat shock genes...
- Drosophila Ge-1 promotes P body formation and oskar mRNA localizationShih Jung Fan
Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
PLoS ONE 6:e20612. 2011..Our findings suggest an important role of dGe-1 in optimization of the osk mRNA localization process required for patterning the Drosophila embryo...
- Separation of stem cell maintenance and transposon silencing functions of Piwi proteinMikhail S Klenov
Department of Molecular Genetics of the Cell, Institute of Molecular Genetics, Russian Academy of Science, Moscow 123182, Russia
Proc Natl Acad Sci U S A 108:18760-5. 2011..We suggest that the Piwi function in GSC self-renewal is independent of transposon repression and is normally realized in the cytoplasm of GSC niche cells...
- Sex chromosome-specific regulation in the Drosophila male germline but little evidence for chromosomal dosage compensation or meiotic inactivationColin D Meiklejohn
Department of Biology, University of Rochester, Rochester, New York, United States of America
PLoS Biol 9:e1001126. 2011..These findings help to resolve several previously conflicting reports and have implications for patterns of genome evolution and speciation in Drosophila...
- Genetic analysis of B2t, the structural gene for a testis-specific beta-tubulin subunit in Drosophila melanogasterK J Kemphues
Genetics 105:345-56. 1983..All four mutant genes encode beta 2-tubulin subunits that are synthesized at normal rates but do not accumulate. All mutants are completely male sterile as homozygotes...
- Drosophila maternal and embryo mRNAs transcribed from a single transcription unit use alternate combinations of exonsA Vincent
EMBO J 3:1003-13. 1984..Multiple mRNAs, transcribed from genes which lie adjacent to a ribosomal protein ( rp49 ) gene, are present during oogenesis, embryogenesis, or both...
- The atonal proneural transcription factor links differentiation and tumor formation in DrosophilaWouter Bossuyt
Laboratory of Neurogenetics, Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium
PLoS Biol 7:e40. 2009..Combined with evidence that atonal's mammalian homolog, ATOH1, is a tumor suppressor gene, our data support a critical, evolutionarily conserved, function for ato in oncogenesis...
- Linker histone H1 is essential for Drosophila development, the establishment of pericentric heterochromatin, and a normal polytene chromosome structureXingwu Lu
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Genes Dev 23:452-65. 2009..Thus, linker histone H1 is essential in Drosophila and plays a fundamental role in the architecture and activity of chromosomes in vivo...
- Expression of Drosophila rhodopsins during photoreceptor cell differentiation: insights into R7 and R8 cell subtype commitmentJames B Earl
Department of Cell and Developmental Biology, University of Colorado at Denver and Health Sciences Center, School of Medicine, RC1 South, Aurora, 80045, USA
Gene Expr Patterns 6:687-94. 2006..This sequence mimics the model for how R7 and R8 photoreceptor cells are specified, and defines the timing of photoreceptor cell fate decisions with respect to other events in eye development...
- The trithorax group and Pc group proteins are differentially involved in heterochromatin formation in DrosophilaLaura Fanti
Istituto Pasteur, Fondazione Cenci Bolognetti, Dipartimento di Genetica e Biologia Molecolare, Universita La Sapienza, 00185, Rome, Italy
Chromosoma 117:25-39. 2008..These results strongly suggest that trx-G proteins, along with some Pc-G proteins, play an active role in heterochromatin formation in Drosophila...
- Eye development under the control of SRp55/B52-mediated alternative splicing of eyelessWeronika Fic
Institut de Génétique Moléculaire de Montpellier IGMM, UMR 5535, Universite de Montpellier II, Centre National de Recherche Scientifique CNRS, Montpellier, France
PLoS ONE 2:e253. 2007..Our results suggest that B52/SRp55 splicing activity is used during normal eye development to control eye organogenesis and size through regulation of eyeless alternative splicing...
- DNA supercoiling factor contributes to dosage compensation in DrosophilaHirofumi Furuhashi
Department of Developmental Genetics, National Institute of Genetics, SOKENDAI, Mishima, Shizuoka ken 411 8540, Japan
Development 133:4475-83. 2006..These findings demonstrate that SCF plays a role in transcriptional activation via alteration of chromatin structure and provide evidence that SCF contributes to dosage compensation...
- Degradation of maternal string mRNA is controlled by proteins encoded on maternally contributed transcriptsF A Myers
Biophysics Laboratory, University of Portsmouth, UK
Mech Dev 51:217-26. 1995..Therefore, the proteins required to activate the degradation of string mRNA are encoded on a maternally contributed mRNA. We discuss possible models to explain the degradation pathway...
- Interspecific comparison of Drosophila serendipity delta and beta: multimodular structure of these C2H2 zinc finger proteinsP Ferrer
Centre de Biologie du Developpement, Scientifique Université Paul Sabatier, Toulouse, France
J Mol Evol 38:263-73. 1994..pseudoobscura sry delta gene rescues the sry delta mutant phenotype. Convergence of genetic and structural data on the sry proteins supports a multimodular function and mode of evolution of these C2H2 finger proteins...
- Transcriptional and developmental functions of the H3.3 histone variant in DrosophilaAkiko Sakai
Department of BCMP, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
Curr Biol 19:1816-20. 2009..Our results imply that the H3.3 variant plays an essential role in chromatin transitions in the male germline...
- Sequence, structure, and codon preference of the Drosophila ribosomal protein 49 geneP O O'Connell
Nucleic Acids Res 12:5495-513. 1984In this communication, we describe several features of the D. melanogaster gene which codes for ribosomal protein 49 (rp49)...
- Physical assessment of toxicology at nanoscale: nano dose-metrics and toxicity factorP P Pompa
Center for Bio Molecular Nanotechnology, Italian Institute of Technology, Via Barsanti 1, 73010 Arnesano, Lecce, Italy
Nanoscale 3:2889-97. 2011..This approach may pave the way to a systematic classification of nanomaterials, leading to important developments in risk assessment and regulatory approval, as well as in a wide range of nanomedicine applications...
- A Drosophila Minute gene encodes a ribosomal proteinK Kongsuwan
Nature 317:555-8. 1985..3-kilobase (kb) region containing the gene encoding the large subunit ribosomal protein 49 (rp49) suppresses the dominant phenotypes of Minute (3)99D, a previously undescribed Minute associated with ..
- Translational regulation of mRNAs for ribosomal proteins during early Drosophila developmentG R Al-Atia
Biochemistry 24:5798-803. 1985..Coordination between r-protein and rRNA synthesis appears to be achieved by regulating translation of r-protein mRNAs in early embryos and by decreasing their abundance in adult tissues...
- Sequence and structure of the serendipity locus of Drosophila melanogaster. A densely transcribed region including a blastoderm-specific geneA Vincent
J Mol Biol 186:149-66. 1985..The predicted beta and delta polypeptides show partial amino acid sequence homology, suggesting a common evolutionary origin...
- Nucleotide sequence comparison of the rp49 gene region between Drosophila subobscura and D. melanogasterM Aguade
Department de Genetica, Facultat de Biologia, Universitat de Barcelona, Spain
Mol Biol Evol 5:433-41. 1988A 1.6-kb fragment encompassing the rp49 gene, which codes for a ribosomal protein, has been cloned and sequenced in Drosophila subobscura. The rp49 coding region has accumulated 46 nucleotide differences out of 402 bp since D...
- Transcriptional and posttranscriptional regulation contributes to the sex-regulated expression of two sequence-related genes at the janus locus of Drosophila melanogasterC Yanicostas
Institut Jacques Monod, Centre National de la Recherche Scientifique, Paris, France
Mol Cell Biol 9:2526-35. 1989..The janA gene displayed a much more complex expression; one of the major mRNAs was found in both sexes and at all stages, whereas the two other janA transcripts were expressed only in males...
- Left hemispheric interference with nonverbal performance in aphasics: comparison with data from split-brain studiesW Hartje
Abteilung Neurologie, RWTH Aachen, West Germany
Brain Cogn 8:137-46. 1988....
- Overproduction and translational regulation of rp49 ribosomal protein mRNA in transgenic Drosophila carrying extra copies of the geneH B Tamate
Department of Genetics, Case Western Reserve University, Cleveland, OH 44106
Mol Gen Genet 221:171-5. 1990..In this study we assayed for changes of ribosomal protein rp49 gene expression in flies transformed with extra copies of the gene...
- The serendipity alpha gene encodes a membrane-associated protein required for the cellularization of the Drosophila embryoF Schweisguth
Institut Jacques Monod, Centre National de la Recherche Scientifique et Université Paris, France
Genes Dev 4:922-31. 1990..The sry alpha protein is associated with the invaginating plasma membrane and colocalizes with F-actin. We propose that sry alpha is involved in the localization of membrane furrows within the syncytial blastoderm...
- Dosage compensation in Drosophila melanogaster male and female embryos generated by segregation distortion of the sex chromosomesC Polito
Department of Genetics, General and Molecular Biology, University of Naples, Italy
Dev Genet 11:249-53. 1990..We have used this scheme to determine that the steady-state levels of transcripts of X-linked genes are the same in early male and female embryos, establishing that these genes are dosage compensated...
- Effect of dietary carbohydrates and ethanol on expression of genes encoding sn-glycerol-3-phosphate dehydrogenase, aldolase, and phosphoglycerate kinase in Drosophila larvaeJ L Lissemore
Department of Biology, Syracuse University, New York 13244 1220
Biochem Genet 28:615-30. 1990....
- Single amino acid exchanges in separate domains of the Drosophila serendipity delta zinc finger protein cause embryonic and sex biased lethalityM Crozatier
Centre de Recherche de Biochimie et de Génétique Cellulaires du CNRS 118, Toulouse, France
Genetics 131:905-16. 1992..The fourth mutation is located in the NH2-proximal part of the protein, in a domain proposed to be involved in specific protein-protein interactions...
- Divergence of the yellow gene between Drosophila melanogaster and D. subobscura: recombination rate, codon bias and synonymous substitutionsA Munte
Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Spain
Genetics 147:165-75. 1997..melanogaster...
- The RRM protein NonA from Drosophila forms a complex with the RRM proteins Hrb87F and S5 and the Zn finger protein PEP on hnRNAI Reim
Institut für Biologie Abt Zytogenetik, Humboldt Universitat zu Berlin, Berlin, D 10115, Germany
Exp Cell Res 253:573-86. 1999..Like NonA, X4/PEP, S5, and P11/Hrb87F are present on active sites on polytene chromosomes. The precipitated NonA complex is enriched for certain protein encoding RNAs, notably, histone H3 and H4 RNA...
- Targeted expression of the DNA binding domain of DRE-binding factor, a Drosophila transcription factor, attenuates DNA replication of the salivary gland and eye imaginal discF Hirose
Laboratory of Cell Biology, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya, 464 8681, Japan
Mol Cell Biol 19:6020-8. 1999..The lines of evidence suggest that the N-terminal fragment can impede the endogenous DREF function in a dominant negative manner and that DREF is required for normal DNA replication in both mitotic cell cycle and endo cycle...
- DHR3 is required for the prepupal-pupal transition and differentiation of adult structures during Drosophila metamorphosisG Lam
Howard Hughes Medical Institute, University of Utah, 15 N 2030 E Rm 5100, Salt Lake City, Utah, 84112 5331, USA
Dev Biol 212:204-16. 1999....
- A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIFP Manfruelli
Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du Centre National de la Recherche Scientifique, 15, rue René Descartes, F 67084 Strasbourg CEDEX, France
EMBO J 18:3380-91. 1999..Finally, we have used fat body cell clones homozygous for various mutations to show that a linear activation cascade Spaetzle--> Toll-->Cactus-->Dorsal/DIF leads to the induction of the drosomycin gene in larval fat body cells...
- Down-regulation of RpS21, a putative translation initiation factor interacting with P40, produces viable minute imagos and larval lethality with overgrown hematopoietic organs and imaginal discsI Torok
Department of Developmental Genetics, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
Mol Cell Biol 19:2308-21. 1999..These data demonstrate a strong interaction between components of the translation machinery and showed that their underexpression impairs the control of cell proliferation in both hematopoietic organs and imaginal discs...
- Mutation in P0, a dual function ribosomal protein/apurinic/apyrimidinic endonuclease, modifies gene expression and position effect variegation in DrosophilaM V Frolov
University of Missouri, Columbia, Missouri 65211, USA
Genetics 150:1487-95. 1998..Recent work revealed that Drosophila ribosomal protein P0 contains an apurinic/apyrimidinic endonuclease activity. Our results suggest that this multifunctional protein is also involved in regulation of gene expression in Drosophila...
- Separate cis-regulatory sequences control expression of serendipity beta and janus A, two immediately adjacent Drosophila genesC Yanicostas
Institut Jacques Monod, CNRS et Université Paris 7, France
Mol Gen Genet 246:549-60. 1995..Together these data indicate that in spite of the physical proximity of the jan A and sry beta genes, their transcription is regulated by separate cis-acting sequences...
- Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganismsB Lemaitre
Institut de Biologie Moleculaire et Cellulaire, Unité Propre de Recherche 9022 du Centre National de la Recherche Scientifique, 15 rue Rene Descartes, 67084 Strasbourg Cedex, France
Proc Natl Acad Sci U S A 94:14614-9. 1997..This response is mediated through the selective activation of the Toll pathway...
- Myosin VI plays a role in cell-cell adhesion during epithelial morphogenesisHadas Millo
Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, UK
Mech Dev 121:1335-51. 2004..Some embryos hatch into larvae, containing detached cells loose in the haemolymph. Myosin VI is crucial for correct cell morphology and maintenance of adhesive cellular contacts within epithelial cell layers...
- Changes in the expression of genes involved in protein synthesis during Drosophila agingN Shikama
Department of Cell Biology, Biozentrum University Basel, Switzerland
Gerontology 42:123-36. 1996..Our data suggest that down-regulation of RNA polymerase I-, II-, and III-mediated transcription may contribute to an age-related decrease in protein synthesis or other homeostatic functions...
- A combined molecular and cytogenetic approach to genome evolution in Drosophila using large-fragment DNA cloningE R Lozovskaya
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138
Chromosoma 102:253-66. 1993..melanogaster. The materials and methods described will make it possible to carry out a direct study of molecular evolution at the level of chromosome structure and organization as well as at the level of individual genes...
- Nucleotide divergence of the rp49 gene region between Drosophila melanogaster and two species of the Obscura group of DrosophilaC Segarra
Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138
J Mol Evol 36:243-8. 1993A 2.1-kb SstI fragment including the rp49 gene and the 3' end of the delta-serendipity gene has been cloned and sequenced in Drosophila pseudoobscura. rp49 maps at region 62 on the tip of chromosome II of this species...
- Transfer of genetic information in the rp49 region of Drosophila subobscura between different chromosomal gene arrangementsJ Rozas
Department de Genetica, Facultat de Biologia, Universitat de Barcelona, Spain
Proc Natl Acad Sci U S A 90:8083-7. 1993Nucleotide variation in the region including the ribosomal protein 49 (rp49) gene was investigated by direct sequencing of 10 alleles of Drosophila subobscura from chromosomes differing in gene arrangements...
- Compositional heterogeneity and patterns of molecular evolution in the Drosophila genomeJ P Carulli
Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110
Genetics 134:837-45. 1993....
- Puffs and PCR: the in vivo dynamics of early gene expression during ecdysone responses in DrosophilaF Huet
Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medecine, Strasbourg, France
Development 118:613-27. 1993..As these molecules have homologues in vertebrates, our analysis may have general implications for the organisation of hormonal responses in vivo...
- Effects of the maleless mutation on X and autosomal gene expression in Drosophila melanogasterJ C Hiebert
Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138
Genetics 136:913-26. 1994..These observations suggest that if mle plays a role in the discrimination of the X and the autosomes, it may do so by modification of the effects of dosage sensitive regulatory genes...
- The timing of drosophila salivary gland apoptosis displays an l(2)gl-dose responseR Farkas
Department of Developmental Genetics, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
Cell Death Differ 7:89-101. 2000....
- Gene expression analysis of the function of the male-specific lethal complex in DrosophilaManika Pal Bhadra
Division of Biological Sciences, University of Missouri, Columbia, 65211, USA
Genetics 169:2061-74. 2005....
- The genetic basis of resistance to diazinon in natural populations of Drosophila melanogasterFiona M Pyke
Department of Genetics, Centre for Environmental Stress and Adaptation Research University of Melbourne, Melbourne, VIC 3010, Australia
Genetica 121:13-24. 2004..Larval resistance levels, due to single genes (or gene complexes) on chromosomes II and III, were significant (15-fold). Evidence indicates that the gene on chromosome II is Cyp6g1...
- Control of poly(A) polymerase level is essential to cytoplasmic polyadenylation and early development in DrosophilaFrançois Juge
Génétique du Développement de la Drosophile, Institut de Genetique Humaine, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
EMBO J 21:6603-13. 2002..This demonstrates that regulation of the PAP level is essential for controlled cytoplasmic polyadenylation and early development...
- Steroid regulation of midgut cell death during Drosophila developmentCheng Yu Lee
Center for Biosystems Research, University of Maryland Biotechnology Institute, University of Maryland, College Park, Maryland 20742, USA
Dev Biol 250:101-11. 2002..These studies indicate that ecdysone triggers a two-step hierarchy composed of steroid-induced regulatory genes and apoptosis genes that, in turn, regulate the autophagic death of midgut cells during development...
- The Drosophila heterochromatic gene encoding poly(ADP-ribose) polymerase (PARP) is required to modulate chromatin structure during developmentAlexei Tulin
Howard Hughes Medical Research Laboratories, Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
Genes Dev 16:2108-19. 2002..We propose that PARP-e autoregulates Parp transcription by influencing the chromatin structure of its heterochromatic environment. Our results indicate that Parp plays a fundamental role organizing the structure of Drosophila chromatin...
- NXF1/p15 heterodimers are essential for mRNA nuclear export in DrosophilaA Herold
European Molecular Biology Laboratory, Heidelberg, Germany
RNA 7:1768-80. 2001..We conclude that Dm NXF1/p15 heterodimers only (but not NXF2-NXF4) mediate the export of the majority of mRNAs in Drosophila cells and that the other members of the NXF family play more specialized or different roles...
- DNA variation at the rp49 gene region of Drosophila simulans: evolutionary inferences from an unusual haplotype structureJ Rozas
Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, 08071 Barcelona, Spain
Genetics 158:1147-55. 2001An approximately 1.3-kb region including the rp49 gene plus its 5' and 3' flanking regions was sequenced in 24 lines of Drosophila simulans (10 from Spain and 14 from Mozambique)...
- The Drosophila E93 gene from the 93F early puff displays stage- and tissue-specific regulation by 20-hydroxyecdysoneE H Baehrecke
Howard Hughes Medical Institute, University of Utah, Salt Lake City 84112
Dev Biol 171:85-97. 1995..We propose that E93 acts in a stage-specific regulatory hierarchy in the salivary gland to direct its histolysis in response to the prepupal ecdysteroid pulse...
- The oxen gene of Drosophila encodes a homolog of subunit 9 of yeast ubiquinol-cytochrome c oxidoreductase complex: evidence for modulation of gene expression in response to mitochondrial activityM V Frolov
University of Missouri, Columbia, Missouri 65211, USA
Genetics 156:1727-36. 2000..The oxen mutation provides a model for the genetic analysis in multicellular organisms of the effect of mitochondrial activity on nuclear gene expression...
- Synthesis of the posterior determinant Nanos is spatially restricted by a novel cotranslational regulatory mechanismI E Clark
Department of Molecular Biology, Princeton University, New Jersey 08544, USA
Curr Biol 10:1311-4. 2000..Thus, synthesis of ectopic Nos protein is inhibited by a novel regulatory mechanism that does not involve a stable arrest of the translation cycle...
- The E23 early gene of Drosophila encodes an ecdysone-inducible ATP-binding cassette transporter capable of repressing ecdysone-mediated gene activationT Hock
Department of Biological Science and Program in Medical Sciences, Florida State University, Tallahassee 32306 4370, USA
Proc Natl Acad Sci U S A 97:9519-24. 2000..Our results suggest the existence of a previously unrecognized regulatory mechanism for modulating steroid hormone signaling in Drosophila...
- Histone acetylation and gene expression analysis of sex lethal mutants in DrosophilaU Bhadra
Division of Biological Sciences, University of Missouri, Columbia 65211, USA
Genetics 155:753-63. 2000..In both cases we find relatively little effect upon X chromosomal gene expression...
- Drosophila Thor participates in host immune defense and connects a translational regulator with innate immunityA Bernal
Department of Biochemistry and Cell Biology, Rice University, 6100 Main Street, Houston, TX 77005, USA
Proc Natl Acad Sci U S A 97:6019-24. 2000..Our results suggest either a role for translational regulation in humoral immunity or a new, nontranslational function for 4E-BP type genes...
- The ecdysone regulatory pathway controls wing morphogenesis and integrin expression during Drosophila metamorphosisP P D'Avino
Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, 15N 2030E, Room 5100, Salt Lake City, Utah 84112 5331, USA
Dev Biol 220:211-24. 2000..We also propose that ecdysone modulation of integrin expression might be widely used to control multiple aspects of adult development...
- The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune responseA Basset
Centre de Genetique Moleculaire, Centre National de la Recherche Scientifique, F 91198 Gif sur Yvette Cedex, France
Proc Natl Acad Sci U S A 97:3376-81. 2000....
- The neuron-enriched splicing pattern of Drosophila erect wing is dependent on the presence of ELAV proteinS P Koushika
Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
Mol Cell Biol 20:1836-45. 2000..Additionally, we report that ELAV promotes a neuron-enriched splice isoform of Drosophila armadillo transcript. ELAV, however, is not involved in all neuron-enriched splice events...
- Generation of Minute phenotypes by a transformed antisense ribosomal protein geneR Patel
Department of Genetics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4955
Dev Genet 13:256-63. 1992..the effects of antisense r-protein 49 expression, a gene known to correspond to a Minute mutation An antisense rp49 gene driven by a strong and inducible promoter was transformed into the Drosophila germ line...
- Genetic Studies of African Anopheles Vectors of MalariaJeffrey Powell; Fiscal Year: 2009..Replacing natural vector populations with such strains require that the strain have high fitness. ..
- Evolution of codon usage bias in the genus DrosophilaJeffrey Powell; Fiscal Year: 2009..willistoni, one of the species being sequenced. ..