RpII18

Summary

Gene Symbol: RpII18
Description: RNA polymerase II 18kD subunit
Alias: BcDNA:RH21608, CG1163, Dm6, Dmel\CG1163, Pol II, PolII, RNA Pol II, RNA pol II, RNA polII, RNAP, RNAP II, RNApolII, RPB6_DROME, RPII18, RpABC14, Rpll18, pol II, polII, CG1163 gene product from transcript CG1163-RA, CG1163-PA, RNA polymerase II, RNA polymerase II (18-kDa subunit), RNA-polymerase ABC 14kD subunit, RpII18-PA
Species: fruit fly

Top Publications

  1. pmc Zygotic genome activation triggers the DNA replication checkpoint at the midblastula transition
    Shelby A Blythe
    Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA
    Cell 160:1169-81. 2015
  2. pmc Identification of multiple cyclin subunits of human P-TEFb
    J Peng
    Department of Biochemistry, University of Iowa, Iowa City, Iowa 52242, USA
    Genes Dev 12:755-62. 1998
  3. ncbi Determination of Coxiella burnetii rpoB sequence and its use for phylogenetic analysis
    C Mollet
    Unite des Rickettsies, CNRS UPRES A 6020, Universite de la Mediterranee, Marseille, France
    Gene 207:97-103. 1998
  4. ncbi Histone variants, nucleosome assembly and epigenetic inheritance
    Steven Henikoff
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Trends Genet 20:320-6. 2004
  5. ncbi Patterning chromatin: form and function for H2A.Z variant nucleosomes
    Ryan M Raisner
    Department of Biochemistry and Biophysics, University of California, 600 16th Street, San Francisco, CA 94143 2240, USA
    Curr Opin Genet Dev 16:119-24. 2006
  6. ncbi Chromatin profiling, DamID and the emerging landscape of gene expression
    Amir Orian
    Vascular and Tumor Biology Research Center, The Rappaport Research Institute and Faculty of Medicine, Technion Israel Institute of Technology, 4 Efron Street, Bat Galim, Haifa 31096, Israel
    Curr Opin Genet Dev 16:157-64. 2006
  7. pmc Paternal transmission of mitochondrial DNA as an integral part of mitochondrial inheritance in metapopulations of Drosophila simulans
    J N Wolff
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
    Heredity (Edinb) 110:57-62. 2013
  8. ncbi Flavopiridol inhibits P-TEFb and blocks HIV-1 replication
    S H Chao
    Molecular Biology Program and the Department of Biochemistry, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 275:28345-8. 2000
  9. ncbi NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1
    Mi Young Kim
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Cell 119:803-14. 2004
  10. ncbi SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation
    Nadezhda E Vorobyeva
    Russian Academy of Sciences, Moscow, Russia
    Cell Cycle 10:1821-7. 2011

Research Grants

Scientific Experts

  • S Henikoff
  • Amir Orian
  • J N Wolff
  • G Seydoux
  • Zhiqiang Zhang
  • John T Lis
  • Shelby A Blythe
  • Nadezhda E Vorobyeva
  • S H Chao
  • D H Price
  • F Sauer
  • David A Hendrix
  • Ryan M Raisner
  • J Peng
  • Jie Yao
  • Yoshiko Mito
  • David S Gilmour
  • Mi Young Kim
  • Amber K Boehm
  • Sarah M Shore
  • Eric F Wieschaus
  • Judith L Leatherman
  • Jennifer A Armstrong
  • J M Park
  • P Morcillo
  • Alexey N Krasnov
  • Vladislav V Panov
  • Sofia G Georgieva
  • Elena N Nabirochkina
  • Julia L Kuzmina
  • Yulii V Shidlovskii
  • Julia V Nikolenko
  • A J Kal
  • V Leclerc
  • I Reim
  • Julia Zeitlinger
  • A D Pham
  • F Schock
  • Michael S Levine
  • S E Robertson
  • Daniel S Rokhsar
  • Joung Woo Hong
  • D Bentley
  • J Lis
  • C Mollet
  • Katherine M Munson
  • Hiten D Madhani
  • Watt W Webb
  • R Sandaltzopoulos
  • Jorja G Henikoff
  • Nicolas Gévry
  • Steven Mauro
  • W Lee Kraus
  • Chwen Huey Wu
  • J T Lis
  • Sarah A Byers
  • Abbie Saunders
  • David H Price
  • Wendy Maury
  • Janis Werner
  • John W Tamkun
  • Matthew P Scott
  • Lissa Levin
  • Thomas A Jongens
  • R J Austin
  • Ophelia Papoulas
  • Gary Daubresse
  • Julie Boero
  • Adam S Sperling
  • R J MacIntyre
  • M D Biggin
  • J M Kim
  • Y J Kim
  • J Werner
  • B M Peterlin
  • R Taube
  • T Mahmoudi
  • A TenHarmsel
  • R Tjian
  • E A Sausville
  • N F Marshall
  • G V Shpakovski
  • K Fujinaga
  • J E Marion
  • P Leopold
  • A M Senderowicz
  • S K Hansen
  • C P Verrijzer
  • S Raisin
  • N B Zak

Detail Information

Publications47

  1. pmc Zygotic genome activation triggers the DNA replication checkpoint at the midblastula transition
    Shelby A Blythe
    Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA
    Cell 160:1169-81. 2015
    ..Measuring RNA polymerase II (Pol II) binding at 20 min intervals over the course of ZGA reveals that the checkpoint coincides with ..
  2. pmc Identification of multiple cyclin subunits of human P-TEFb
    J Peng
    Department of Biochemistry, University of Iowa, Iowa City, Iowa 52242, USA
    Genes Dev 12:755-62. 1998
    ..factor b (P-TEFb) through phosphorylation of the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. Drosophila P-TEFb was identified recently as a cyclin-dependent kinase (CDK9) paired with a cyclin subunit (..
  3. ncbi Determination of Coxiella burnetii rpoB sequence and its use for phylogenetic analysis
    C Mollet
    Unite des Rickettsies, CNRS UPRES A 6020, Universite de la Mediterranee, Marseille, France
    Gene 207:97-103. 1998
    ..burnetii belongs to the gamma-group of Proteobacteria. Furthermore, phylogeny inferred from comparison of RpoB, or homologous sequences including Archae, Bacteria and Eukarya, concurred with these results...
  4. ncbi Histone variants, nucleosome assembly and epigenetic inheritance
    Steven Henikoff
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Trends Genet 20:320-6. 2004
  5. ncbi Patterning chromatin: form and function for H2A.Z variant nucleosomes
    Ryan M Raisner
    Department of Biochemistry and Biophysics, University of California, 600 16th Street, San Francisco, CA 94143 2240, USA
    Curr Opin Genet Dev 16:119-24. 2006
    ..This chromatin pattern is generated through the action of a DNA deposition signal and a specific pattern of histone tail acetylation...
  6. ncbi Chromatin profiling, DamID and the emerging landscape of gene expression
    Amir Orian
    Vascular and Tumor Biology Research Center, The Rappaport Research Institute and Faculty of Medicine, Technion Israel Institute of Technology, 4 Efron Street, Bat Galim, Haifa 31096, Israel
    Curr Opin Genet Dev 16:157-64. 2006
    ..The molecular picture that emerges from DamID and similar studies is that genomes integrate inputs from both genetic and epigenetic machineries to dynamically regulate gene expression...
  7. pmc Paternal transmission of mitochondrial DNA as an integral part of mitochondrial inheritance in metapopulations of Drosophila simulans
    J N Wolff
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
    Heredity (Edinb) 110:57-62. 2013
    ..Our findings further suggest that this phenomenon to potentially be an integral part of mtDNA inheritance in these populations and consequently of significance for mtDNA as a molecular marker...
  8. ncbi Flavopiridol inhibits P-TEFb and blocks HIV-1 replication
    S H Chao
    Molecular Biology Program and the Department of Biochemistry, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 275:28345-8. 2000
    ..We found that the flavonoid potently inhibited transcription by RNA polymerase II in vitro by blocking the transition into productive elongation, a step controlled by P-TEFb...
  9. ncbi NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1
    Mi Young Kim
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Cell 119:803-14. 2004
    ..Thus, PARP-1 functions both as a structural component of chromatin and a modulator of chromatin structure through its intrinsic enzymatic activity...
  10. ncbi SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation
    Nadezhda E Vorobyeva
    Russian Academy of Sciences, Moscow, Russia
    Cell Cycle 10:1821-7. 2011
    ..The knockdown of SAYP leads to a decrease in the level of DHR3-activated transcription. DHR3 and SAYP interact during development and have multiple common targets across the genome...
  11. pmc The Drosophila brahma complex is an essential coactivator for the trithorax group protein zeste
    A J Kal
    Department of Molecular and Cell Biology, MGC, Centre for Biomedical Genetics, Leiden University Medical Centre, 2300 RA Leiden, The Netherlands
    Genes Dev 14:1058-71. 2000
    ..These results establish that different chromatin remodeling factors display distinct functional properties and provide novel insights into the mechanism of their targeting...
  12. ncbi germ cell-less is required only during the establishment of the germ cell lineage of Drosophila and has activities which are dependent and independent of its localization to the nuclear envelope
    S E Robertson
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6069, USA
    Dev Biol 215:288-97. 1999
    ..These results indicate that gcl acts in at least two different ways during the establishment of the germ cell lineage...
  13. ncbi Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo
    S H Chao
    Molecular Biology Program, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 276:31793-9. 2001
    ..We examined the ability of flavopiridol to inhibit P-TEFb (Cdk9/cyclin T1) phosphorylation of both RNA polymerase II and the large subunit of the 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) sensitivity-inducing ..
  14. ncbi Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shock
    J M Park
    National Creative Research Initiative Center for Genome Regulation, Department of Biochemistry, Yonsei University, 120 749, Seoul, South Korea
    Mol Cell 8:9-19. 2001
    Activators of RNA polymerase II (Pol II) transcription have been shown to bind several coactivators and basal factors in vitro...
  15. ncbi Genetic and molecular characterization of a variegating hsp70-acZ fusion gene in the euchromatic 31 B region of Drosophila melanogaster
    P Morcillo
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Genome 44:698-707. 2001
    ..However, other modifiers of PEV did not affect the expression pattern of the gene. These results show a novel euchromatic tissue-specific variegation that is not associated with classical heterochromatic PEV...
  16. pmc The Drosophila BRM complex facilitates global transcription by RNA polymerase II
    Jennifer A Armstrong
    Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA
    EMBO J 21:5245-54. 2002
    ..Reduction of BRM function dramatically reduces the association of RNA polymerase II with salivary gland chromosomes...
  17. pmc Dominant-negative mutants reveal a role for the Cdk7 kinase at the mid-blastula transition in Drosophila embryos
    V Leclerc
    Institute of Signaling, Developmental Biology and Cancer Research, UMR 6543 CNRS, Centre de Biochimie, Parc Valrose, 06108 Nice, Cedex 2, France
    EMBO J 19:1567-75. 2000
    ..found in the transcription factor complex TFIIH, suggesting that it participates in vivo in the control of RNA polymerase II. We have examined the physiological role of Cdk7 during the course of Drosophila development...
  18. ncbi germ cell-less acts to repress transcription during the establishment of the Drosophila germ cell lineage
    Judith L Leatherman
    Cell and Molecular Biology Graduate Program, University of Pennsylvania Shool of Medicine, Philadelphia, PA 19104 6100, USA
    Curr Biol 12:1681-5. 2002
    ....
  19. ncbi Identification of a novel isoform of Cdk9
    Sarah M Shore
    Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA
    Gene 307:175-82. 2003
    Positive transcription factor b (P-TEFb) is required for RNA polymerase II to make the transition from abortive to productive elongation...
  20. pmc Transcription factor and polymerase recruitment, modification, and movement on dhsp70 in vivo in the minutes following heat shock
    Amber K Boehm
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Mol Cell Biol 23:7628-37. 2003
    ..Here we examine the rapid changes upon heat shock in levels and location of heat shock factor (HSF), RNA polymerase II (Pol II) and its phosphorylated forms, and the Pol II kinase P-TEFb on hsp70 in vivo by using both real-time ..
  21. ncbi Analysis of polymerase II elongation complexes by native gel electrophoresis. Evidence for a novel carboxyl-terminal domain-mediated termination mechanism
    Zhiqiang Zhang
    Center for Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 279:23223-8. 2004
    ..approach using native gel electrophoresis for studying interactions of elongation factors with isolated Pol II elongation complexes. The gel distinguishes Pol IIA and Pol IIB containing complexes...
  22. ncbi Genome-scale profiling of histone H3.3 replacement patterns
    Yoshiko Mito
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Nat Genet 37:1090-7. 2005
    ..3 replacement over active genes and transposons. H3.3 replacement occurred prominently at sites of abundant RNA polymerase II and methylated H3 Lys4 throughout the genome and was enhanced on the dosage-compensated male X chromosome...
  23. ncbi Pcf11 is a termination factor in Drosophila that dismantles the elongation complex by bridging the CTD of RNA polymerase II to the nascent transcript
    Zhiqiang Zhang
    Department of Biochemistry and Molecular Biology, Center for Gene Regulation, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Mol Cell 21:65-74. 2006
    The mechanism by which Pol II terminates transcription in metazoans is not understood. We show that Pcf11 is directly involved in termination in Drosophila...
  24. ncbi Dynamics of heat shock factor association with native gene loci in living cells
    Jie Yao
    Field of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    Nature 442:1050-3. 2006
    ..After heat shock, we have visualized the recruitment of RNA polymerase II (Pol II) to native hsp70 gene loci 87A and 87C in real time...
  25. pmc Promoter elements associated with RNA Pol II stalling in the Drosophila embryo
    David A Hendrix
    Department Molecular and Cell Biology, Division of Genetics, Genomics, and Development, Center for Integrative Genomics, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 105:7762-7. 2008
    b>RNA Polymerase II (Pol II) is bound to the promoter regions of many or most developmental control genes before their activation during Drosophila embryogenesis...
  26. ncbi Multiple TAFIIs directing synergistic activation of transcription
    F Sauer
    Science 270:1783-8. 1995
    ..Thus, the concerted action of multiple regulators with different coactivators helps to establish the pattern and level of segmentation gene transcription during Drosophila development...
  27. ncbi Comparative analysis of four parameters involved in puffing activity along chromosome arm 2L of D melanogaster
    N Visa
    Departament de Biologia Cellular i Fisiologia, Facultat de Ciencies, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Biol Cell 73:71-8. 1991
    ..On the other hand, puffs of similar size incorporate 3H-uridine at quite different rates. The presence of RNA polymerase II seems to follow a coincident pattern with that of 3H-uridine incorporation...
  28. ncbi A Drosophila anti-RNA polymerase II antibody recognizes a plant nucleolar antigen, RNA polymerase I, which is mostly localized in fibrillar centres
    M Martin
    Centro de Investigaciones Biologicas CSIC, Madrid, Spain
    J Cell Sci 100:99-107. 1991
    ..onion root meristematic cells has been studied by means of an antibody originally raised against Drosophila RNA polymerase II. This antibody recognizes the homologous domains of the large subunit of the enzyme, which are highly ..
  29. ncbi Transcription elongation and eukaryotic gene regulation
    C A Spencer
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Oncogene 5:777-85. 1990
    Each step in the synthesis of functional transcript by RNA polymerase II provides a level at which gene expression can be regulated...
  30. ncbi Fractionation of the general RNA polymerase II transcription factors from Drosophila embryos
    S L Wampler
    Department of Biology, University of California, San Diego, La Jolla 92093
    J Biol Chem 265:21223-31. 1990
    We have subdivided the components of the basic RNA polymerase II machinery from Drosophila embryos into three fractions and RNA polymerase II. The RNA polymerase II was 90% homogeneous and possessed the IIa form of the largest subunit...
  31. ncbi A cytological and molecular analysis of Adh gene expression in Drosophila melanogaster polytene chromosomes
    N Visa
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Spain
    Chromosoma 97:171-7. 1988
    ..The presence of RNA polymerase II in this puff as well as its ability to incorporate tritiated uridine shows that it corresponds to a ..
  32. pmc Bending DNA can repress a eukaryotic basal promoter and inhibit TFIID binding
    A TenHarmsel
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8114, USA
    Mol Cell Biol 15:5492-8. 1995
    ..binding and leads to the formation of a DNA loop which encompasses the DNA sequences normally bound by the RNA polymerase II general transcription factors...
  33. pmc Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae
    G V Shpakovski
    Departement de Biologie Moleculaire et Cellulaire, Commissariat à l Energie Atomique Saclay, Gif sur Yvette, France
    Mol Cell Biol 15:4702-10. 1995
    ..suppressors of rpo21-4, a mutation generating a slowly growing yeast defective in the largest subunit of RNA polymerase II. Finally, a doubly chimeric S...
  34. ncbi Locus-specific variation in phosphorylation state of RNA polymerase II in vivo: correlations with gene activity and transcript processing
    J R Weeks
    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710
    Genes Dev 7:2329-44. 1993
    ..CTDs), respectively, we have visualized the in vivo distributions of the differentially phosphorylated forms of Pol II on Drosophila polytene chromosomes...
  35. pmc Reverse genetics of Drosophila RNA polymerase II: identification and characterization of RpII140, the genomic locus for the second-largest subunit
    B J Hamilton
    Department of Biochemistry, Duke University, Durham, North Carolina 27710
    Genetics 134:517-29. 1993
    We have used a reverse genetics approach to isolate genes encoding two subunits of Drosophila melanogaster RNA polymerase II. RpII18 encodes the 18-kDa subunit and maps cytogenetically to polytene band region 83A...
  36. pmc In vivo transcriptional pausing and cap formation on three Drosophila heat shock genes
    E B Rasmussen
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14853
    Proc Natl Acad Sci U S A 90:7923-7. 1993
    ..On the uninduced hsp70 gene of Drosophila melanogaster, for example, an RNA polymerase II complex has initiated transcription but has paused early in elongation...
  37. ncbi The RRM protein NonA from Drosophila forms a complex with the RRM proteins Hrb87F and S5 and the Zn finger protein PEP on hnRNA
    I Reim
    Institut für Biologie Abt Zytogenetik, Humboldt Universitat zu Berlin, Berlin, D 10115, Germany
    Exp Cell Res 253:573-86. 1999
    ..Like NonA, X4/PEP, S5, and P11/Hrb87F are present on active sites on polytene chromosomes. The precipitated NonA complex is enriched for certain protein encoding RNAs, notably, histone H3 and H4 RNA...
  38. ncbi DNA template and activator-coactivator requirements for transcriptional synergism by Drosophila bicoid
    F Sauer
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720 3204, USA
    Science 270:1825-8. 1995
    ..Thus, contact between multiple activation domains of BCD and different targets within the TFIID complex can mediate transcriptional synergism...
  39. pmc Purification of the Drosophila RNA polymerase II general transcription factors
    R J Austin
    Department of Molecular Biophysics and Biochemistry, Yale University, CT 06520 8114, USA
    Proc Natl Acad Sci U S A 93:5788-92. 1996
    We describe a fractionation and purification scheme for the Drosophila RNA polymerase II general transcription factors...
  40. ncbi Transcriptionally repressed germ cells lack a subpopulation of phosphorylated RNA polymerase II in early embryos of Caenorhabditis elegans and Drosophila melanogaster
    G Seydoux
    Department of Molecular Biology and Genetics, Johns Hopkins University, School of Medicine, Baltimore, MD 21205 2185, USA
    Development 124:2191-201. 1997
    ..mRNA production correlates with the absence of a specific phosphoepitope on the carboxy-terminal domain of RNA polymerase II. In both C...
  41. pmc Heat shock factor increases the reinitiation rate from potentiated chromatin templates
    R Sandaltzopoulos
    Gene Expression Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Mol Cell Biol 18:361-7. 1998
    Transcription by RNA polymerase II is highly regulated at the level of initiation and elongation...
  42. ncbi Identification of a cyclin subunit required for the function of Drosophila P-TEFb
    J Peng
    Department of Biochemistry, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 273:13855-60. 1998
    ..elongation and is capable of phosphorylating the carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II. We cloned a cDNA encoding the large subunit of Drosophila P-TEFb and found the predicted protein contained ..
  43. ncbi RNA processing. A tale of two tails
    D Bentley
    Nature 395:21-2. 1998
  44. pmc Drosophila head segmentation factor buttonhead interacts with the same TATA box-binding protein-associated factors and in vivo DNA targets as human Sp1 but executes a different biological program
    F Schock
    Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Am Fassberg, 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 96:5061-5. 1999
    ....
  45. ncbi Promoter-associated pausing in promoter architecture and postinitiation transcriptional regulation
    J Lis
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    Cold Spring Harb Symp Quant Biol 63:347-56. 1998
  46. ncbi Mesoderm-determining transcription in Drosophila is alleviated by mutations in TAF(II)60 and TAF(II)110
    A D Pham
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Germany
    Mech Dev 84:3-16. 1999
    ..The results provide evidence that TAF(II)-subunits within the TFIID complex play an important role during the molecular events leading to initiation of mesoderm formation in Drosophila...
  47. pmc Stability of Drosophila RNA polymerase II elongation complexes in vitro
    D D Kephart
    Department of Biochemistry, University of Iowa, Iowa City 52242
    Mol Cell Biol 12:2067-77. 1992
    We show that nuclear extract from Drosophila Kc cells supports efficient elongation by RNA polymerase II initiated from the actin 5C promoter. The addition of 0...

Research Grants2

  1. ALIGNMENT BASED METHODS FOR MOLECULAR SEQUENCE ANALYSIS
    Steven Henikoff; Fiscal Year: 2001
    ..This effort could yield new eukaryotic family members of great importance for understanding epigenetic phenomena, some of which, such as parental imprinting, are relevant to human disease. ..
  2. Maintenance of blocks-based tools for functional genomic
    Steven Henikoff; Fiscal Year: 2006
    ..These various components will be packaged to facilitate updates and local implementations. [unreadable] [unreadable]..