Rel

Summary

Gene Symbol: Rel
Description: Relish
Alias: CG11992, Dmel\CG11992, NF-kappaB, NFkappaB, REL, RELI, Rel-p110, Rel/NF-kappaB, RelA, ird, ird4, l(3)neo36, rel, relish, CG11992 gene product from transcript CG11992-RA, CG11992-PA, CG11992-PB, CG11992-PC, CG11992-PD, Rel-PA, Rel-PB, Rel-PC, Rel-PD, immune response deficient 4, nuclear factor NF-kappa-B p110 subunit, positive regulation of transcription from RNA polymerase II promoter; GO:0045944 , IMP, relish
Species: fruit fly

Top Publications

  1. ncbi Drosophila innate immunity: a genomic view of pathogen defense
    Heinrich Jasper
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Mol Cell 10:967-9. 2002
  2. pmc DEAF-1 regulates immunity gene expression in Drosophila
    Darien E Reed
    Helen Diller Family Comprehensive Cancer Center and Cancer Research Institute, University of California, San Francisco, CA 94115 0128, USA
    Proc Natl Acad Sci U S A 105:8351-6. 2008
  3. pmc Evolutionary conserved regulation of HIF-1β by NF-κB
    Patrick van Uden
    Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, United Kingdom
    PLoS Genet 7:e1001285. 2011
  4. doi Regulation of DUOX by the Galphaq-phospholipase Cbeta-Ca2+ pathway in Drosophila gut immunity
    Eun Mi Ha
    Division of Life and Pharmaceutical Science, Ewha Woman s University, Seoul 120 750, South Korea
    Dev Cell 16:386-97. 2009
  5. doi Innate immune homeostasis by the homeobox gene caudal and commensal-gut mutualism in Drosophila
    Ji Hwan Ryu
    Division of Molecular Life Science, Ewha Woman s University and National Creative Research Initiative Center for Symbiosystem, Seoul 120 750, South Korea
    Science 319:777-82. 2008
  6. pmc Reduced expression of alpha-1,2-mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans
    Ya Lin Liu
    Department of Life Science and Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan
    Aging Cell 8:370-9. 2009
  7. pmc Caspar, a suppressor of antibacterial immunity in Drosophila
    Myungjin Kim
    National Creative Research Initiatives Center for Cell Growth Regulation and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Kusong Dong, Yusong, Taejon 305 701, Korea
    Proc Natl Acad Sci U S A 103:16358-63. 2006
  8. ncbi A humoral stress response in Drosophila
    S Ekengren
    Umea Centre for Molecular Pathogenesis, Umea University, S 90 187, Umea, Sweden
    Curr Biol 11:714-8. 2001
  9. ncbi In vivo RNA interference analysis reveals an unexpected role for GNBP1 in the defense against Gram-positive bacterial infection in Drosophila adults
    Sebastien Pili-Floury
    Centre de Genetique Moleculaire, CNRS, F 91198 Gif sur Yvette Cedex, France
    J Biol Chem 279:12848-53. 2004
  10. ncbi Immunity regulatory DNAs share common organizational features in Drosophila
    Kate Senger
    Department of Molecular and Cellular Biology, Division of Genetics and Development, University of California, Berkeley, Berkeley, CA 94720, USA
    Mol Cell 13:19-32. 2004

Research Grants

Scientific Experts

Detail Information

Publications125 found, 100 shown here

  1. ncbi Drosophila innate immunity: a genomic view of pathogen defense
    Heinrich Jasper
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Mol Cell 10:967-9. 2002
  2. pmc DEAF-1 regulates immunity gene expression in Drosophila
    Darien E Reed
    Helen Diller Family Comprehensive Cancer Center and Cancer Research Institute, University of California, San Francisco, CA 94115 0128, USA
    Proc Natl Acad Sci U S A 105:8351-6. 2008
    ..The coexpression of DEAF-1 with Dorsal, Dif, and Relish results in the synergistic activation of transcription...
  3. pmc Evolutionary conserved regulation of HIF-1β by NF-κB
    Patrick van Uden
    Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, United Kingdom
    PLoS Genet 7:e1001285. 2011
    ..These results reveal a novel mechanism of HIF regulation, with impact in the development of novel therapeutic strategies for HIF-related pathologies including ageing, ischemia, and cancer...
  4. doi Regulation of DUOX by the Galphaq-phospholipase Cbeta-Ca2+ pathway in Drosophila gut immunity
    Eun Mi Ha
    Division of Life and Pharmaceutical Science, Ewha Woman s University, Seoul 120 750, South Korea
    Dev Cell 16:386-97. 2009
    ..These results demonstrate that the Galphaq-PLCbeta-Ca(2+)-DUOX-ROS signaling pathway acts as a bona fide first line of defense that enables gut epithelia to dynamically control yeast during the Drosophila life cycle...
  5. doi Innate immune homeostasis by the homeobox gene caudal and commensal-gut mutualism in Drosophila
    Ji Hwan Ryu
    Division of Molecular Life Science, Ewha Woman s University and National Creative Research Initiative Center for Symbiosystem, Seoul 120 750, South Korea
    Science 319:777-82. 2008
    ..These results reveal that a specific genetic deficiency within a host can profoundly influence the gut commensal microbial community and host physiology...
  6. pmc Reduced expression of alpha-1,2-mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans
    Ya Lin Liu
    Department of Life Science and Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan
    Aging Cell 8:370-9. 2009
    ..These findings suggested that mutations in mas1 may extend longevity by modulating DR...
  7. pmc Caspar, a suppressor of antibacterial immunity in Drosophila
    Myungjin Kim
    National Creative Research Initiatives Center for Cell Growth Regulation and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Kusong Dong, Yusong, Taejon 305 701, Korea
    Proc Natl Acad Sci U S A 103:16358-63. 2006
    ..negatively regulated the immune deficiency (Imd)-mediated immune responses by blocking nuclear translocation of Relish, an NF-kappaB transcription factor...
  8. ncbi A humoral stress response in Drosophila
    S Ekengren
    Umea Centre for Molecular Pathogenesis, Umea University, S 90 187, Umea, Sweden
    Curr Biol 11:714-8. 2001
    ..Although TotA is only induced by severe stress, it responds to a much wider range of stimuli than heat shock genes such as hsp70 or immune genes such as Cecropin A1...
  9. ncbi In vivo RNA interference analysis reveals an unexpected role for GNBP1 in the defense against Gram-positive bacterial infection in Drosophila adults
    Sebastien Pili-Floury
    Centre de Genetique Moleculaire, CNRS, F 91198 Gif sur Yvette Cedex, France
    J Biol Chem 279:12848-53. 2004
    ..Altogether, our results demonstrate that the detection of Gram-positive bacteria in Drosophila requires two putative pattern recognition receptors, PGRP-SA and GNBP1...
  10. ncbi Immunity regulatory DNAs share common organizational features in Drosophila
    Kate Senger
    Department of Molecular and Cellular Biology, Division of Genetics and Development, University of California, Berkeley, Berkeley, CA 94720, USA
    Mol Cell 13:19-32. 2004
    ..of transcription factors have been implicated in this process: the REL-containing proteins, Dorsal, Dif, and Relish, and the GATA factor Serpent...
  11. ncbi Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury
    Herve Agaisse
    Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Dev Cell 5:441-50. 2003
    ..In addition, we demonstrate that totA activation also requires the NF-KB-like Relish pathway, indicating that fat body cells integrate the activity of NF-KB and JAK/STAT signaling pathways upon ..
  12. pmc The homeobox gene Caudal regulates constitutive local expression of antimicrobial peptide genes in Drosophila epithelia
    Ji Hwan Ryu
    Division of Molecular Life Science and Center for Cell Signaling Research, Ewha Womans University, Seoul, South Korea
    Mol Cell Biol 24:172-85. 2004
    ..These results suggest that certain epithelial tissues have evolved a unique constitutive innate immune strategy by recruiting a developmental "master control" gene...
  13. pmc An RNA interference screen identifies Inhibitor of Apoptosis Protein 2 as a regulator of innate immune signalling in Drosophila
    Viola Gesellchen
    German Cancer Research Center DKFZ, Boveri Group Signaling and Functional Genomics, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    EMBO Rep 6:979-84. 2005
    ..Our results indicate that IAP gene family members may have acquired other functions, such as the regulation of the tumour necrosis factor-like IMD pathway during innate immune responses...
  14. pmc Rudra interrupts receptor signaling complexes to negatively regulate the IMD pathway
    Kamna Aggarwal
    Divison of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Pathog 4:e1000120. 2008
    ..These results show that Rudra is a critical component in a negative feedback loop, whereby immune-induced gene expression rapidly produces a potent inhibitor that binds and inhibits pattern recognition receptors...
  15. pmc A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway
    Nicolas Buchon
    Global Health Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 106:12442-7. 2009
    ..It also reveals the conserved role of modular serine proteases in the activation of insect immune reactions...
  16. ncbi Role of Drosophila IKK gamma in a toll-independent antibacterial immune response
    S Rutschmann
    Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du CNRS, 15, rue R Descartes, F67084 Strasbourg, France
    Nat Immunol 1:342-7. 2000
    ..Our data show that Drosophila IKK gamma is required for the Relish-dependent immune induction of the genes encoding antibacterial peptides and for resistance to infections by ..
  17. pmc The antibacterial arm of the drosophila innate immune response requires an IkappaB kinase
    Y Lu
    Molecular Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Genes Dev 15:104-10. 2001
    ..The ird5 gene encodes a Drosophila homolog of mammalian IkappaB kinases (IKKs). The ird5 phenotype and sequence suggest that the gene is specifically required for the activation of Relish, a Drosophila NF-kappaB family member.
  18. pmc Discrete functions of TRAF1 and TRAF2 in Drosophila melanogaster mediated by c-Jun N-terminal kinase and NF-kappaB-dependent signaling pathways
    Guang Ho Cha
    National Creative Research Initiatives Center for Cell Growth Regulation, and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Kusong Dong, Yusong, Taejon 305 701, Republic of Korea
    Mol Cell Biol 23:7982-91. 2003
    ..Ectopic expression of DTRAF2 induced nuclear translocation of two Drosophila NF-kappaBs, DIF and Relish, consequently activating the transcription of the antimicrobial peptide genes diptericin, diptericin-like protein, ..
  19. ncbi The immune response of Drosophila
    Jules A Hoffmann
    Institut de Biologie Moleculaire et Cellulaire du CNRS, 67084 Strasbourg Cedex, France
    Nature 426:33-8. 2003
    ..Recent progress in research on Drosophila immune defence provides evidence for similarities and differences between Drosophila immune responses and mammalian innate immunity...
  20. ncbi Differential activation of the NF-kappaB-like factors Relish and Dif in Drosophila melanogaster by fungi and Gram-positive bacteria
    Marika Hedengren-Olcott
    Department of Zoology, Oregon State University, 220 Nash Hall, Corvallis, OR 97331, USA
    J Biol Chem 279:21121-7. 2004
    ..G(+)) bacteria activate the Toll/Dif pathway and that Gram-negative (G(-)) bacteria activate the Imd/Relish pathway...
  21. pmc Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila
    M S Dushay
    Department of Developmental Biology, Stockholm University, Sweden
    Proc Natl Acad Sci U S A 93:10343-7. 1996
    ..We identified the gene for Relish, a compound Drosophila protein that, like mammalian p105 and p100, contains both a Rel homology domain and an I ..
  22. ncbi Regulated nuclear import of Rel proteins in the Drosophila immune response
    L P Wu
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nature 392:93-7. 1998
    ..as the mammalian innate immune response, including signalling pathways that activate transcription factors of the Rel/NK-kappaB family...
  23. ncbi Phylogenetic perspectives in innate immunity
    J A Hoffmann
    Institute of Molecular and Cellular Biology, CNRS, Strasbourg, 67084, France
    Science 284:1313-8. 1999
    ..In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity...
  24. ncbi Interaction and specificity of Rel-related proteins in regulating Drosophila immunity gene expression
    Z S Han
    Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 274:21355-61. 1999
    ..Furthermore, the drosomycin and defensin expression is best induced by the Relish/Dif and the Relish/Dorsal heterodimers, respectively, whereas the attacin activity can be efficiently up-regulated ..
  25. pmc Adaptive evolution of relish, a Drosophila NF-kappaB/IkappaB protein
    D J Begun
    Section of Integrative Biology and Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas 78712, USA
    Genetics 154:1231-8. 2000
    ..Here we present a molecular population genetic analysis of Relish, a Drosophila NF-kappaB/IkappaB protein, in Drosophila simulans and D. melanogaster...
  26. ncbi Interactions between the cellular and humoral immune responses in Drosophila
    M Elrod-Erickson
    Whitehead Institute, Cambridge, MA 02142, USA
    Curr Biol 10:781-4. 2000
    ....
  27. pmc A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity
    N Silverman
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 14:2461-71. 2000
    ..We show that this complex is required for the signal-dependent cleavage of Relish, a member of the Rel family of transcriptional activator proteins, and for the activation of antibacterial immune ..
  28. pmc Activation of the Drosophila NF-kappaB factor Relish by rapid endoproteolytic cleavage
    S Stoven
    Umeå Center for Molecular Pathogenesis, Umea University, Sweden
    EMBO Rep 1:347-52. 2000
    The Rel/NF-kappaB transcription factor Relish plays a key role in the humoral immune response in Drosophila. We now find that activation of this innate immune response is preceded by rapid proteolytic cleavage of Relish into two parts...
  29. pmc The Drosophila caspase Dredd is required to resist gram-negative bacterial infection
    F Leulier
    Centre de Genetique Moleculaire, Centre National de la Recherche Scientifique, France
    EMBO Rep 1:353-8. 2000
    ..demonstrate that Dredd regulates antibacterial peptide gene expression, and we propose that Dredd, Immune Deficiency and the P105-like rel protein Relish define a pathway that is required to resist gram-negative bacterial infections.
  30. ncbi Cactus-independent nuclear translocation of Drosophila RELISH
    W D Cornwell
    Department of Gene Expression Sciences, GlaxoSmithKline Pharmaceuticals, King of Prussia, Pennsylvania, USA
    J Cell Biochem 82:22-37. 2001
    ..here for a molecular mechanism of Lipopolysaccharide (LPS)-induced signaling involving Drosophila NF-kappaB, RELISH, in Drosophila S2 cells...
  31. ncbi Enteric bacteria counteract lipopolysaccharide induction of antimicrobial peptide genes
    H Lindmark
    Department of Comparative Physiology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    J Immunol 167:6920-3. 2001
    ..suggests that the inhibitory effect is upstream or at the level of the activation of the transcription factor Relish, a member of the NF-kappaB/Rel family...
  32. ncbi Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila
    Kwang Min Choe
    Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Science 296:359-62. 2002
    ..recognition protein, PGRP-LC, is absolutely required for the induction of antibacterial peptide genes in response to infection in Drosophila and acts by controlling activation of the NF-kappaB family transcription factor Relish.
  33. pmc Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae
    Aya Takehana
    Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980 8578, Japan
    Proc Natl Acad Sci U S A 99:13705-10. 2002
    ..Therefore, PGRP-LE acts as a pattern-recognition receptor to the diaminopimelic acid-type peptidoglycan and activates both the proteolytic cascade and intracellular signaling in Drosophila immunity...
  34. ncbi An immune-responsive Serpin regulates the melanization cascade in Drosophila
    Ennio De Gregorio
    Centre de Génétique Moléculaire du CNRS, 91198 Gif sur Yvette, France
    Dev Cell 3:581-92. 2002
    ..Our data demonstrate that Serpin-27A is required to restrict the phenoloxidase activity to the site of injury or infection, preventing the insect from excessive melanization...
  35. pmc Caspase-mediated processing of the Drosophila NF-kappaB factor Relish
    Svenja Stoven
    Umea Centre for Molecular Pathogenesis, Umea University, S 901 87 Umea, Sweden
    Proc Natl Acad Sci U S A 100:5991-6. 2003
    The NF-kappaB-like transcription factor Relish plays a central role in the innate immune response of Drosophila...
  36. pmc Functional characterization of a novel promoter element required for an innate immune response in Drosophila
    Hanna Uvell
    Department of Molecular Biology and Functional Genomics, Arrhenius Laboratories for Natural Sciences, Stockholm University, SE 106 91 Stockholm, Sweden
    Mol Cell Biol 23:8272-81. 2003
    ..The induced gene expression relies on translocation of the Drosophila Rel transcription factors Relish, Dif, and Dorsal to the nucleus where they bind to kappaB-like motifs in the promoters of the inducible genes...
  37. ncbi The roles of JAK/STAT signaling in Drosophila immune responses
    Herve Agaisse
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Immunol Rev 198:72-82. 2004
    ....
  38. ncbi Hemolymph-dependent and -independent responses in Drosophila immune tissue
    Raul Bettencourt
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Cell Biochem 92:849-63. 2004
    ..Using GFP-Dorsal, -Dif, and -Relish reporter proteins in ex vivo assays, we demonstrate that Drosophila fat bodies, a major immune tissue, have both ..
  39. ncbi An antioxidant system required for host protection against gut infection in Drosophila
    Eun Mi Ha
    Division of Molecular Life Science and Center for Cell Signaling Research, Ewha Womans University, Seoul 120 750, South Korea
    Dev Cell 8:125-32. 2005
    ..These results imply that homeostasis of redox balance by IRC is one of the most critical factors affecting host survival during continuous host-microbe interaction in the gastrointestinal tract...
  40. pmc Drosophila peptidoglycan recognition protein LC (PGRP-LC) acts as a signal-transducing innate immune receptor
    Kwang Min Choe
    Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:1122-6. 2005
    ..of a cytoplasmic signaling cascade that requires the death-domain protein Imd and an IkappaB kinase to activate Relish, an NF-kappaB family member...
  41. ncbi An epidermal barrier wound repair pathway in Drosophila is mediated by grainy head
    Kimberly A Mace
    Section of Cell and Developmental Biology, Division of Biology, University of California, San Diego, La Jolla, CA 92093, USA
    Science 308:381-5. 2005
    ..The conservation of this Grh-dependent pathway suggests that the repair of insect cuticle and mammal skin is controlled by an ancient, shared control system for constructing and healing the animal body surface barrier...
  42. pmc Ligand-induced dimerization of Drosophila peptidoglycan recognition proteins in vitro
    Peter Mellroth
    Department of Genetics, Microbiology, and Toxicology, University of Stockholm, S 106 91 Stockholm, Sweden
    Proc Natl Acad Sci U S A 102:6455-60. 2005
    ..PGRP-LCx, the default peptidoglycan receptor of the Imd/Relish pathway, has strong affinity for all polymeric peptidoglycans tested and for monomeric peptidoglycan...
  43. pmc The Toll pathway is important for an antiviral response in Drosophila
    Robert A Zambon
    Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, MD 20742, USA
    Proc Natl Acad Sci U S A 102:7257-62. 2005
    ..Additionally, our results demonstrate the validity of using a genetic approach to identify genes and pathways used in viral innate immune responses in Drosophila...
  44. pmc The RING-finger scaffold protein Plenty of SH3s targets TAK1 to control immunity signalling in Drosophila
    Manabu Tsuda
    Department of Biological Sciences, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji shi, Tokyo 192 0397, Japan
    EMBO Rep 6:1082-7. 2005
    ..response to infection by Gram-negative bacteria and leads to the activation of Jun amino-terminal kinase (JNK) and Relish, a nuclear factor-kappaB transcription factor responsible for the expression of antimicrobial peptides...
  45. ncbi The serine protease Sp7 is expressed in blood cells and regulates the melanization reaction in Drosophila
    Casimiro Castillejo-Lopez
    Department of Experimental Medical Science and Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, BMC B13, Klinikgatan 26, 22184 Lund, Sweden
    Biochem Biophys Res Commun 338:1075-82. 2005
    ....
  46. pmc Prophenoloxidase activation is not required for survival to microbial infections in Drosophila
    Vincent Leclerc
    UPR9022 du CNRS, IBMC, 15 rue Descartes, 67084 Strasbourg, France
    EMBO Rep 7:231-5. 2006
    ..This raises the question with regard to the precise function of phenoloxidase activation in defence, if any...
  47. ncbi Drosophila immunity: a large-scale in vivo RNAi screen identifies five serine proteases required for Toll activation
    Zakaria Kambris
    Centre de Genetique Moleculaire, CNRS, Gif sur Yvette, France
    Curr Biol 16:808-13. 2006
    ..These results demonstrate the existence of a common cascade of SPs upstream of Spz, integrating signals sent by various secreted recognition molecules via more specialized SPs...
  48. pmc Cooperative control of Drosophila immune responses by the JNK and NF-kappaB signaling pathways
    Joseph R Delaney
    Brookdale Department of Developmental, Cell and Molecular Biology, The Mount Sinai School of Medicine, New York, NY, USA
    EMBO J 25:3068-77. 2006
    ..Drosophila TAK1 has been implicated in the NF-kappaB/Relish-mediated activation of antimicrobial peptide genes...
  49. ncbi Two proteases defining a melanization cascade in the immune system of Drosophila
    Huaping Tang
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    J Biol Chem 281:28097-104. 2006
    ..We have also shown that the melanization reaction activated by MP1 and MP2 plays an important role in augmenting the effectiveness of other immune reactions, thereby promoting resistance of Drosophila to microbial infection...
  50. pmc The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection
    François Leulier
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK
    Mol Cell Biol 26:7821-31. 2006
    ..Our genetic epistasis analysis places diap2 downstream of or in parallel to imd, Dredd, Tak1, and Relish. Therefore, DIAP2 functions in the host immune response to gram-negative bacteria...
  51. ncbi Expression and regulation of Spätzle-processing enzyme in Drosophila
    Shai Mulinari
    Department of Experimental Medical Science and Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, BMC B13, Klinikgatan 26, 22184 Lund, Sweden
    FEBS Lett 580:5406-10. 2006
    ....
  52. ncbi Crystal cell rupture after injury in Drosophila requires the JNK pathway, small GTPases and the TNF homolog Eiger
    Gawa Bidla
    Department of Molecular Biology and Functional Genomics, University of Stockholm, Svante Arrheniusväg 16 18, SE 10691 Stockholm, Sweden
    J Cell Sci 120:1209-15. 2007
    ..Our results provide a more comprehensive view of immune signal transduction pathways, with implications for immune reactions where cell death is used as a terminal mode of cell activation...
  53. pmc Toll and IMD pathways synergistically activate an innate immune response in Drosophila melanogaster
    Takahiro Tanji
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell Biol 27:4578-88. 2007
    ..These results illustrate how specific ligand binding by separate upstream pattern recognition receptors can be translated into a broad-spectrum host response, a hallmark of innate immunity...
  54. ncbi Nematodes, bacteria, and flies: a tripartite model for nematode parasitism
    Elissa A Hallem
    Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Curr Biol 17:898-904. 2007
    ....
  55. pmc Interaction between sleep and the immune response in Drosophila: a role for the NFkappaB relish
    Julie A Williams
    Center for Advanced Biotechnology and Medicine and Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Piscataway 08854 5603, USA
    Sleep 30:389-400. 2007
    ..The Drosophila model for sleep provides a powerful system to identify and test the role of sleep-relevant molecules...
  56. ncbi A Drosophila ortholog of the human cylindromatosis tumor suppressor gene regulates triglyceride content and antibacterial defense
    Theodore Tsichritzis
    Institute of Immunology, Biomedical Sciences Research Center Al Fleming, 34 Al Fleming Street, 16672 Vari, Greece
    Development 134:2605-14. 2007
    ..All mutant phenotypes described were reversible upon conditional expression of CYLD transgenes. Our results implicate CYLD in a broad range of functions associated with fat homeostasis and host defence in Drosophila...
  57. pmc Down-regulation of NF-kappaB target genes by the AP-1 and STAT complex during the innate immune response in Drosophila
    Lark Kyun Kim
    Department of Biochemistry, National Creative Research Initiative Center for Genome Regulation, Yonsei University, Seoul, Korea
    PLoS Biol 5:e238. 2007
    ..The dAP-1-, Stat92E-, and Dsp1-containing complexes replace Relish at the promoters of diverse immune effector genes by binding to evolutionarily conserved cis-elements, and they ..
  58. pmc NF-kappaB/Rel-mediated regulation of the neural fate in Drosophila
    Savita Ayyar
    Department of Zoology, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 2:e1178. 2007
    Two distinct roles are described for Dorsal, Dif and Relish, the three NF-kappaB/Rel proteins of Drosophila, in the development of the peripheral nervous system...
  59. pmc Drosophila melanogaster mounts a unique immune response to the Rhabdovirus sigma virus
    C W Tsai
    Department of Entomology, The Ohio State University OARDC, Wooster, Ohio 44691, USA
    Appl Environ Microbiol 74:3251-6. 2008
    ..These results highlight shared and unique aspects of the Drosophila immune response to the three viruses and may shed light on the nature of the interaction with the host and the evolution of these associations...
  60. ncbi Pirk is a negative regulator of the Drosophila Imd pathway
    Anni Kleino
    Institute of Medical Technology, University of Tampere, Finland
    J Immunol 180:5413-22. 2008
    ..Furthermore, pirk-overexpressing flies were more susceptible to Gram-negative bacterial infection than wild-type flies. We conclude that Pirk is a negative regulator of the Imd pathway...
  61. pmc Loss of p24 function in Drosophila melanogaster causes a stress response and increased levels of NF-kappaB-regulated gene products
    Kara A Boltz
    Department of Biology, Texas A and M University, College Station, TX, USA
    BMC Genomics 9:212. 2008
    ..We tested the hypothesis that loss of Drosophila melanogaster p24 protein function causes a transcriptional response characteristic of ER stress activation...
  62. pmc Autophagic control of listeria through intracellular innate immune recognition in drosophila
    Tamaki Yano
    Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980 8578, Japan
    Nat Immunol 9:908-16. 2008
    ..Autophagy induction occurred independently of the Toll and IMD innate signaling pathways. Our findings define a pathway leading from the intracellular pattern-recognition receptors to the induction of autophagy to host defense...
  63. doi PIMS modulates immune tolerance by negatively regulating Drosophila innate immune signaling
    Nouara Lhocine
    CNRS, Centre de Genetique Moleculaire, UPR2167, Gif sur Yvette, F 91198, France
    Cell Host Microbe 4:147-58. 2008
    ..Therefore, PIMS is required to establish immune tolerance to commensal bacteria and to maintain a balanced Imd response following exposure to bacterial infections...
  64. doi Dnr1-dependent regulation of the Drosophila immune deficiency signaling pathway
    Silvia Guntermann
    Department of Medical Microbiology and Immunology, University of Alberta, Alberta Institute for Viral Immunology, Edmonton AB, T6G 2S2, Canada
    Dev Comp Immunol 33:127-34. 2009
    ..Additionally, we provide molecular data to indicate that Dnr1 inhibits the Imd pathway at the level of the initiator caspase Dredd...
  65. pmc Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes
    Deniz Erturk-Hasdemir
    Division of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 106:9779-84. 2009
    The Drosophila NF-kappaB transcription factor Relish is an essential regulator of antimicrobial peptide gene induction after gram-negative bacterial infection...
  66. doi Genetic ablation of Drosophila phagocytes reveals their contribution to both development and resistance to bacterial infection
    Arnaud Defaye
    Centre de Genetique Moleculaire, CNRS FRE 3144, Gif sur Yvette, France
    J Innate Immun 1:322-34. 2009
    ..We now provide a blueprint of phagocyte importance during both development and innate immune responses in Drosophila...
  67. pmc Peroxiredoxin 5 modulates immune response in Drosophila
    Svetlana N Radyuk
    Department of Biological Sciences, Southern Methodist University, 6501 Airline Rd, Room 113, Dallas, TX 75275, USA
    Biochim Biophys Acta 1800:1153-63. 2010
    ..Previously, we reported on the potent antioxidant function of Drosophila peroxiredoxin 5 (dPrx5). Studies with mammalian and human cells suggest that peroxiredoxins can modulate immune-related signaling...
  68. doi Eye transformer is a negative regulator of Drosophila JAK/STAT signaling
    Jenni Kallio
    Laboratory of Experimental Immunology, Institute of Medical Technology, Tampere University, Tampere, Finland
    FASEB J 24:4467-79. 2010
    ..In conclusion, we have identified ET as a novel negative regulator of the Drosophila JAK/STAT pathway both in vitro and in vivo, and it functions in regulating Stat92E phosphorylation...
  69. pmc Heterodimers of NF-kappaB transcription factors DIF and Relish regulate antimicrobial peptide genes in Drosophila
    Takahiro Tanji
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 107:14715-20. 2010
    ..Dorsal and DIF act downstream of Toll, whereas Relish acts downstream of IMD to regulate target gene expression...
  70. pmc Drosophila melanogaster as a model for human intestinal infection and pathology
    Yiorgos Apidianakis
    Department of Surgery, Massachusetts General Hospital, 50 Blossom Street, Their 340, Boston, MA 02114, USA
    Dis Model Mech 4:21-30. 2011
    ..In this Perspective, we discuss recent advances in the study of Drosophila intestinal infection and pathology, and briefly review the parallels and differences between human and Drosophila intestinal regeneration and disease...
  71. pmc Drosophila immunity: analysis of PGRP-SB1 expression, enzymatic activity and function
    Anna Zaidman-Rémy
    Centre de Génétique Moléculaire du CNRS, Gif sur Yvette, France
    PLoS ONE 6:e17231. 2011
    ..Possible immune functions of PGRP-SB1 are discussed...
  72. pmc Lack of an antibacterial response defect in Drosophila Toll-9 mutant
    Karine Narbonne-Reveau
    Institut de Biologie du Developpement de Marseille Luminy, CNRS UMR 6216 Aix Marseille II University, Campus de Luminy, Marseille, France
    PLoS ONE 6:e17470. 2011
    ..Our results suggest that Toll-9 is neither required to maintain a basal anti-microbial response nor to mount an efficient immune response to bacterial infection...
  73. pmc Alternative pathway of cell death in Drosophila mediated by NF-κB transcription factor Relish
    Yashodhan Chinchore
    Department of Biology, Dartmouth College, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 109:E605-12. 2012
    ..Here, we report that the NF-κB transcription factor Relish regulates neuronal cell death...
  74. pmc The Drosophila protein mustard tailors the innate immune response activated by the immune deficiency pathway
    Zhipeng Wang
    Division of Infectious Diseases, Children s Hospital Boston, Boston, MA 02115, USA
    J Immunol 188:3993-4000. 2012
    ..We show that this Mtd isoform does not block Relish cleavage or translocation into the nucleus...
  75. pmc Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling
    Annika Meinander
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, London, UK
    EMBO J 31:2770-83. 2012
    ..Signal-dependent ubiquitylation of DREDD is required for full processing of IMD, NF-κB/Relish and expression of antimicrobial peptide genes in response to infection with Gram-negative bacteria...
  76. doi Peptidoglycan sensing by the receptor PGRP-LE in the Drosophila gut induces immune responses to infectious bacteria and tolerance to microbiota
    Virginie Bosco-Drayon
    Institut de Biologie du Developpement de Marseille Luminy, CNRS UMR, Aix Marseille Universite, France
    Cell Host Microbe 12:153-65. 2012
    ..Together these data indicate that PGRP-LE functions as a master gut bacterial sensor that induces balanced responses to infectious bacteria and tolerance to microbiota...
  77. ncbi Relish, a central factor in the control of humoral but not cellular immunity in Drosophila
    M Hedengren
    Umeå Center for Molecular Pathogenesis, Umea University, Sweden
    Mol Cell 4:827-37. 1999
    The NF-kappa B-like Relish gene is complex, with four transcripts that are all located within an intron of the Nmdmc gene...
  78. pmc Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses
    S Vidal
    Centre de Genetique Moleculaire, CNRS, 91198 Gif sur Yvette, France
    Genes Dev 15:1900-12. 2001
    ..Imd protein and upstream of the IKK complex in the Imd pathway that controls the Rel/NF-kappaB like transactivator Relish. In addition, our epistatic analysis places the caspase, Dredd, downstream of the IKK complex, which supports the ..
  79. ncbi AP-1, but not NF-kappa B, is required for efficient steroid-triggered cell death in Drosophila
    M Lehmann
    Howard Hughes Medical Institute, Department of Human Genetics, 15 North 2030 East Room 5100, University of Utah, Utah, UT 84112 5331, USA
    Cell Death Differ 9:581-90. 2002
    Extensive studies in vertebrate cells have assigned a central role to Rel/NF-kappa B and AP-1 family members in the control of apoptosis...
  80. ncbi A ubiquitin-proteasome pathway represses the Drosophila immune deficiency signaling cascade
    Ranjiv S Khush
    Centre de Genetique Moleculaire, Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France
    Curr Biol 12:1728-37. 2002
    ..the NF-kappaB homologs, Dorsal and DIF; and the IMD pathway that regulates the compound NF-kappaB-like protein, Relish. Although numerous components of each pathway that are required to induce antimicrobial gene expression have been ..
  81. pmc Peptidoglycan recognition protein (PGRP)-LE and PGRP-LC act synergistically in Drosophila immunity
    Aya Takehana
    Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Sendai, Japan
    EMBO J 23:4690-700. 2004
    ..A role for PGRP-LE in the epithelial induction of antimicrobial peptides is also suggested...
  82. ncbi Aging of the innate immune response in Drosophila melanogaster
    Melissa Zerofsky
    Brown University, Division of Biology and Medicine, Providence, RI 02912, USA
    Aging Cell 4:103-8. 2005
    ..Consequently, maximum reproduction will occur when the immune response is tightly controlled in young females, even if this increases infection risk at later ages...
  83. ncbi Drosophila sex-peptide stimulates female innate immune system after mating via the Toll and Imd pathways
    Jing Peng
    Zoological Institute, University of Zurich Irchel, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Curr Biol 15:1690-4. 2005
    ..Mating may physically damage females and pathogens may be transferred. Thus, endogenous stimulation of AMP transcription by SP at mating might be considered as a preventive step to encounter putative immunogenic attacks...
  84. ncbi The Drosophila amidase PGRP-LB modulates the immune response to bacterial infection
    Anna Zaidman-Rémy
    Centre de Génétique Moléculaire du CNRS, F 91198 Gif sur Yvette, France
    Immunity 24:463-73. 2006
    ..Our work highlights the key role of PGRPs that encode both sensors and scavengers of peptidoglycan, which modulate the level of the host immune response to the presence of infectious microorganisms...
  85. pmc An essential complementary role of NF-kappaB pathway to microbicidal oxidants in Drosophila gut immunity
    Ji Hwan Ryu
    Division of Molecular Life Science and National Creative Research Initiative Center for Symbiosystem, Ewha Woman s University, Seoul, South Korea
    EMBO J 25:3693-701. 2006
    ..This high lethality can be significantly reduced by either re-introducing Relish expression to Relish mutants or by constitutively expressing a single AMP to the NF-kappaB pathway mutants in the ..
  86. pmc Conserved catalytic and C-terminal regulatory domains of the C-terminal binding protein corepressor fine-tune the transcriptional response in development
    Yang W Zhang
    Department of Biochemistry and Molecular Biology, Michigan State University, 413 Biochemistry, East Lansing, MI 48824 1319, USA
    Mol Cell Biol 31:375-84. 2011
    ..Our results indicate that the structural and enzymatic features of CtBP, previously thought to be dispensable for overall transcriptional control, are critical for modulating this protein's activity in diverse developmental settings...
  87. ncbi Cytotoxicity and cytotoxic molecules in invertebrates
    A J Nappi
    Department of Biology, Loyola University, Chicago, IL 60626, USA
    Bioessays 22:469-80. 2000
    ..The signal transduction pathways that are involved in mediating the production of these substances appear to be very similar among animal species, suggesting a common ancestral origin for the innate immune systems...
  88. ncbi The fly caspases
    S Kumar
    Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, PO Box 14, Rundle Mall, Adelaide, SA 5000, Australia
    Cell Death Differ 7:1039-44. 2000
    ..The presence of multiple caspases in Drosophila indicates that apoptotic pathways in insects are likely to be as complex as in vertebrates...
  89. pmc The Drosophila atypical protein kinase C-ref(2)p complex constitutes a conserved module for signaling in the toll pathway
    Antonia Avila
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma, Canto Blanco, 28049 Madrid, Spain
    Mol Cell Biol 22:8787-95. 2002
    ..to be important for the other Drosophila NF-kappaB signaling cascade, which activates the NF-kappaB homologue Relish in response to lipopolysaccharides...
  90. pmc Innate immunity in fruit flies: a textbook example of genomic recycling
    Shubha Govind
    Department of Biology and The Graduate Center, City College of New York, New York, New York, USA
    PLoS Biol 2:E276. 2004
  91. ncbi Nef induces apoptosis by activating JNK signaling pathway and inhibits NF-kappaB-dependent immune responses in Drosophila
    Sung Bae Lee
    National Creative Research Initiatives Center for Cell Growth Regulation and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Taejon 305 701, Korea
    J Cell Sci 118:1851-9. 2005
    ..Furthermore, we found that ectopic expression of Nef inhibits Drosophila innate immune responses including Relish NF-kappaB activation with subsequent induction of an antimicrobial peptide, diptericin...
  92. pmc IKK epsilon signaling: not just NF-kappaB
    Andreas Bergmann
    The University of Texas MD Anderson Cancer Center, Department of Biochemistry and Molecular Biology, 1515 Holcombe Blvd Unit 1000, Houston, Texas 77030, USA
    Curr Biol 16:R588-90. 2006
    ..Surprisingly, three recent reports implicate IKKs in Drosophila in seemingly unrelated functions, including non-apoptotic caspase activation and cytoskeleton organization...
  93. pmc GATA factors participate in tissue-specific immune responses in Drosophila larvae
    Kate Senger
    Department of Molecular and Cell Biology, Division of Genetics, Genomics, and Development, Center for Integrative Genomics, University of California, Berkeley, CA 94720 3204, USA
    Proc Natl Acad Sci U S A 103:15957-62. 2006
    ..The regulation of antimicrobial genes in larval fat depends on linked Rel/NF-kappaB and GATA binding sites. Serpent functions as the major GATA transcription factor in the larval fat body...
  94. pmc Comparative population genetics of the immunity gene, Relish: is adaptive evolution idiosyncratic?
    Mia T Levine
    Center for Population Biology, University of California at Davis, Davis, California, United States of America
    PLoS ONE 2:e442. 2007
    ..We asked whether the immunity factor, Relish, a gene with a history of directional selection in Drosophila simulans, shows evidence of a similar selective ..
  95. doi Age-related upregulation of Drosophila caudal gene via NF-kappaB in the adult posterior midgut
    Yoon Jeong Choi
    Department of Molecular Biology, College of Natural Science, Pusan National University, Busan 609 735, Republic of Korea
    Biochim Biophys Acta 1780:1093-100. 2008
    ..Our results may contribute to an understanding of the mechanisms of age-related changes in the number and activity of intestinal stem cells and progenitors in the Drosophila adult midgut...
  96. pmc The Toll-->NFkappaB signaling pathway mediates the neuropathological effects of the human Alzheimer's Abeta42 polypeptide in Drosophila
    Lihua Tan
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
    PLoS ONE 3:e3966. 2008
    ....
  97. pmc Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep
    Susan T Harbison
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Nat Genet 41:371-5. 2009
    ..We confirmed co-regulated gene expression using P-element mutants. Quantitative genetic analysis of natural phenotypic variation is an efficient method for revealing candidate genes and pathways...
  98. doi Transcriptional profiling of the sperm storage organs of Drosophila melanogaster
    A M Prokupek
    School of Biological Sciences, University of Nebraska Lincoln, Lincoln, Nebraska, USA
    Insect Mol Biol 18:465-75. 2009
    ..Differences in functional gene categories indicate that these organs play unique roles in sperm storage...
  99. pmc Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila
    Nicolas Buchon
    Global Health Institute, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Genes Dev 23:2333-44. 2009
    ..Altogether, these results indicate that gut homeostasis is achieved by a complex interregulation of the immune response, gut microbiota, and stem cell activity...
  100. pmc Drosophila translational elongation factor-1gamma is modified in response to DOA kinase activity and is essential for cellular viability
    Yujie Fan
    Department of Molecular Genetics, Microbiology and Immunology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Genetics 184:141-54. 2010
    ..Our data suggest that EF1gamma functions in vital cellular processes in addition to translational elongation and is a LAMMER kinase substrate in vivo...

Research Grants2

  1. The Role of Peroxiredoxins in Immunity and Aging
    SVETLANA RADYUK; Fiscal Year: 2006
    ..This will set the stage for a more thorough investigation of the molecular underpinnings of innate immunity during aging. ..
  2. Genomics of improved immunity in Drosophila melanogaster
    KURT MCKEAN; Fiscal Year: 2005
    ....