Rdl

Summary

Gene Symbol: Rdl
Description: Resistant to dieldrin
Alias: CG10537, CT29555, DmRDL, DmRdl, Dmel\CG10537, GABA, GABA-R, GABA[[A]], GABA[[A]] receptor, GABA[[A]]-R, GABA[[A]]R, GABAr, LCCH1, RDL, Rd1, gaba, rdl, CG10537 gene product from transcript CG10537-RE, CG10537-PA, CG10537-PC, CG10537-PD, CG10537-PE, CG10537-PF, CG10537-PG, GABA A beta-subunit, GABA receptor, GABA[[A]] receptor, Rdl-PA, Rdl-PC, Rdl-PD, Rdl-PE, Rdl-PF, Rdl-PG, resistance to dieldrin, resistant to dieldrin
Species: fruit fly

Top Publications

  1. ncbi Molecular biology of insect neuronal GABA receptors
    A M Hosie
    Babraham Institute, Dept of Zoology, Cambridge, UK
    Trends Neurosci 20:578-83. 1997
  2. ncbi Isolation of dieldrin resistance from field populations of Drosophila melanogaster (Diptera: Drosophilidae)
    R H ffrench-Constant
    Department of Entomology, Cornell University, Ithaca, New York 14853
    J Econ Entomol 83:1733-7. 1990
  3. pmc A unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanisms
    H G Zhang
    Department of Physiology, Medical School, College of Agricultural and Life Sciences, University of Wisconsin, Madison 53706
    J Physiol 479:65-75. 1994
  4. ncbi Characterization of a putative gamma-aminobutyric acid (GABA) receptor beta subunit gene from Drosophila melanogaster
    J E Henderson
    New York State Agricultural Experiment Station, Cornell University, Geneva 14456
    Biochem Biophys Res Commun 193:474-82. 1993
  5. pmc A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated with cyclodiene insecticide resistance in Drosophila populations
    R H ffrench-Constant
    Department of Entomology, University of Wisconsin, Madison 53706
    Proc Natl Acad Sci U S A 90:1957-61. 1993
  6. ncbi A point mutation in a Drosophila GABA receptor confers insecticide resistance
    R H ffrench-Constant
    Department of Entomology, 237 Russell Laboratories, University of Wisconsin, Madison 53706
    Nature 363:449-51. 1993
  7. pmc Allosteric modulation of an expressed homo-oligomeric GABA-gated chloride channel of Drosophila melanogaster
    A M Hosie
    Department of Zoology, University of Cambridge
    Br J Pharmacol 117:1229-37. 1996
  8. pmc Agonist pharmacology of two Drosophila GABA receptor splice variants
    A M Hosie
    Department of Zoology, University of Cambridge
    Br J Pharmacol 119:1577-85. 1996
  9. pmc The effect of a transmembrane amino acid on etomidate sensitivity of an invertebrate GABA receptor
    K A McGurk
    Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, Dundee University, Scotland
    Br J Pharmacol 124:13-20. 1998
  10. ncbi Transcriptional analysis of the Drosophila GABA receptor gene resistance to dieldrin
    G E Stilwell
    Center for Environmental Toxicology and Department of Entomology, University of Wisconsin Madison, 53706, USA
    J Neurobiol 36:468-84. 1998

Research Grants

  1. A TOXIN BASED DROSOPHILA PARKINSON'S DISEASE MODEL
    Geoffrey Stilwell; Fiscal Year: 2005

Scientific Experts

  • Toshifumi Nakao
  • Archan Ganguly
  • John E Pool
  • Pushkar Paranjpe
  • Ralph Hillman
  • John E Casida
  • Geoff E Stilwell
  • Natalia Sánchez-Soriano
  • H Xue
  • E Zlotkin
  • F Grolleau
  • D Schneider
  • Richard R Copley
  • Alfred M Handler
  • R ffrench-Constant
  • Adrian Rothenfluh
  • CHARLES HOEFFER
  • A M Hosie
  • D B Sattelle
  • James E C Jepson
  • Xu Liu
  • Leslie C Griffith
  • S D Buckingham
  • Agata Kolodziejczyk
  • Shin Ichiro Tachibana
  • EMILY PETRUCCELLI
  • Sien Braat
  • Paula R Haynes
  • Mohan T Bolisetty
  • Valentina Carta
  • Sha Liu
  • Ana Rita Santos
  • David B Sattelle
  • Yuhua Shang
  • Yi Li
  • Liam P Keegan
  • Michael Rosbash
  • R Frank Kooy
  • Ian McGonigle
  • Robert A Reenan
  • Kei Ito
  • Sebastian Busch
  • Andrew K Jones
  • Ryuichi Okada
  • Brian Y Chung
  • Steven W Ludmerer
  • H G Zhang
  • K Matsuda
  • Jacob Shun Jen Yang
  • Jose Agosto
  • Ronald L Davis
  • Yingcong Zheng
  • Dick R Nassel
  • Steven D Buckingham
  • Lina Enell
  • K Narusuye
  • J J Rauh
  • Charlotte D'Hulst
  • Mladen Iovchev
  • Daria S Hekmat-Scafe
  • Alastair M Hosie
  • Alain Hamon
  • Gaelle Le Goff
  • Evgeny A Glazov
  • K Aronstein
  • Anne Isabelle Munier
  • H A Baylis
  • F Shotkoski
  • M B Jackson
  • Matthias Landgraf
  • Barry Hoopengardner
  • Kazushige Touhara
  • Toshihiro Kitamoto
  • Bethany L Christmann
  • Brenton R Graveley
  • Gopinath Rajadinakaran
  • Aki Ejima
  • Patrick Lansdon
  • Kwang Min Choe
  • Paula R Towers
  • Julia Zhang
  • Kyunghee Koh
  • Qili Liu
  • Roshan Puthenkalam
  • Alexandros K Kanellopoulos
  • Michael Pangerl
  • Dirk Trauner
  • David C Hunt
  • Margot Ernst
  • Joseph Bedont

Detail Information

Publications103 found, 100 shown here

  1. ncbi Molecular biology of insect neuronal GABA receptors
    A M Hosie
    Babraham Institute, Dept of Zoology, Cambridge, UK
    Trends Neurosci 20:578-83. 1997
    Ionotropic gamma-aminobutyric acid (GABA) receptors are distributed throughout the nervous systems of many insect species...
  2. ncbi Isolation of dieldrin resistance from field populations of Drosophila melanogaster (Diptera: Drosophilidae)
    R H ffrench-Constant
    Department of Entomology, Cornell University, Ithaca, New York 14853
    J Econ Entomol 83:1733-7. 1990
    High levels (about 4,000-fold) of resistance to dieldrin were isolated by screening field-collected populations of Drosophila melanogaster (Meigen). The resistance was made homozygous following 2-4 generations of selection...
  3. pmc A unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanisms
    H G Zhang
    Department of Physiology, Medical School, College of Agricultural and Life Sciences, University of Wisconsin, Madison 53706
    J Physiol 479:65-75. 1994
    1. The Drosophila gene Rdl (resistance to dieldrin) encodes a GABA receptor. An alanine-to-serine mutation in this gene at residue 302 confers resistance to cyclodiene insecticides and picrotoxin...
  4. ncbi Characterization of a putative gamma-aminobutyric acid (GABA) receptor beta subunit gene from Drosophila melanogaster
    J E Henderson
    New York State Agricultural Experiment Station, Cornell University, Geneva 14456
    Biochem Biophys Res Commun 193:474-82. 1993
    ..Among characterized members of this gene family, this gene exhibits the greatest similarity to GABA receptor beta subunit genes...
  5. pmc A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated with cyclodiene insecticide resistance in Drosophila populations
    R H ffrench-Constant
    Department of Entomology, University of Wisconsin, Madison 53706
    Proc Natl Acad Sci U S A 90:1957-61. 1993
    ....
  6. ncbi A point mutation in a Drosophila GABA receptor confers insecticide resistance
    R H ffrench-Constant
    Department of Entomology, 237 Russell Laboratories, University of Wisconsin, Madison 53706
    Nature 363:449-51. 1993
    ..Previously, we used a field-isolated Drosophila mutant Rdl (Resistant to dieldrin) insensitive to PTX and cyclodienes to clone a putative GABA receptor...
  7. pmc Allosteric modulation of an expressed homo-oligomeric GABA-gated chloride channel of Drosophila melanogaster
    A M Hosie
    Department of Zoology, University of Cambridge
    Br J Pharmacol 117:1229-37. 1996
    1. Functional GABA-gated chloride channels are formed when cRNA encoding the Drosophila melanogaster GABA receptor subunit RDL is injected into the cytoplasm of Xenopus oocytes...
  8. pmc Agonist pharmacology of two Drosophila GABA receptor splice variants
    A M Hosie
    Department of Zoology, University of Cambridge
    Br J Pharmacol 119:1577-85. 1996
    ..The differences in the potency of agonists on RDLac and DRC 17-1-2 homo-oligomers observed in the present study may assist in identification of further molecular determinants of GABA receptor function.
  9. pmc The effect of a transmembrane amino acid on etomidate sensitivity of an invertebrate GABA receptor
    K A McGurk
    Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, Dundee University, Scotland
    Br J Pharmacol 124:13-20. 1998
    ..the equivalent amino acid (M314) on the actions of this anaesthetic at an etomidate-insensitive invertebrate GABA receptor (Rdl) of Drosophila melanogaster. 2...
  10. ncbi Transcriptional analysis of the Drosophila GABA receptor gene resistance to dieldrin
    G E Stilwell
    Center for Environmental Toxicology and Department of Entomology, University of Wisconsin Madison, 53706, USA
    J Neurobiol 36:468-84. 1998
    The Resistance to dieldrin (Rdl) gene encodes a novel subunit of a gamma-aminobutyric acid (GABA)-gated chloride ion channel in Drosophila...
  11. pmc Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin
    N S Kane
    Merck Research Laboratories, Merck and Co, Inc, PO Box 2000, R80Y 250, Rahway, NJ 07065, USA
    Proc Natl Acad Sci U S A 97:13949-54. 2000
    ....
  12. ncbi Alternative splicing of a Drosophila GABA receptor subunit gene identifies determinants of agonist potency
    A M Hosie
    Babraham Institute, Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, Downing Street, CB2 3EJ, Cambridge, UK
    Neuroscience 102:709-14. 2001
    Alternative splicing of the Drosophila melanogaster Rdl gene yields four ionotropic GABA receptor subunits. The two Rdl splice variants cloned to date, RDL(ac) and RDL(bd) (DRC17-1-2), differ in their apparent agonist affinity...
  13. ncbi Identification of two novel Drosophila melanogaster histamine-gated chloride channel subunits expressed in the eye
    Yingcong Zheng
    Merck Research Laboratories, Merck and Co, Inc, Rahway, New Jersey 07065, USA
    J Biol Chem 277:2000-5. 2002
    ..either HisCl1 or HisCl2, produced substantial chloride currents in response to histamine but not in response to GABA, glycine, and glutamate. The histamine sensitivity was similar to that observed in insect laminar neurons...
  14. ncbi Ivermectin and nodulisporic acid receptors in Drosophila melanogaster contain both gamma-aminobutyric acid-gated Rdl and glutamate-gated GluCl alpha chloride channel subunits
    Steven W Ludmerer
    Department of Parasite Biochemistry and Molecular Biology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Biochemistry 41:6548-60. 2002
    ..chloride channel subunit GluCl alpha (DmGluCl alpha) and the GABA-gated chloride channel subunit Rdl (DmRdl) proteins were generated and used to examine the possible coassembly of these two subunits within a single ..
  15. ncbi Putative histamine-gated chloride channel subunits of the insect visual system and thoracic ganglion
    Ines Witte
    Zoologisches Institut, Abteilung Neurophysiologie, Universitat Hamburg, Hamburg, Germany
    J Neurochem 83:504-14. 2002
    ..These ion-channels are the first specific molecular markers for postsynaptic cells in the insect visual system, thus representing ideal tools to study its physiology and development...
  16. ncbi Nervous system targets of RNA editing identified by comparative genomics
    Barry Hoopengardner
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Science 301:832-6. 2003
    ..These results point to a pivotal role for RNA editing in nervous system function...
  17. ncbi Resistance to fipronil in Drosophila simulans: influence of two point mutations in the RDL GABA receptor subunit
    Gaelle Le Goff
    UMR 1112, INRA Université de Nice Sophia Antipolis, Sophia Antipolis, France
    J Neurochem 92:1295-305. 2005
    ..Molecular cloning of the cDNA encoding the RDL GABA receptor subunit of this strain revealed the presence of two mutations: the Rdl mutation (A301G) and an additional ..
  18. pmc Ultraconserved elements in insect genomes: a highly conserved intronic sequence implicated in the control of homothorax mRNA splicing
    Evgeny A Glazov
    ARC Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
    Genome Res 15:800-8. 2005
    ....
  19. ncbi Are dendrites in Drosophila homologous to vertebrate dendrites?
    Natalia Sánchez-Soriano
    Faculty of Life Sciences, WTCCMR, The University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Dev Biol 288:126-38. 2005
    ..Implications of these findings for studies of dendrite development, neuronal polarity, transport and evolution are discussed...
  20. ncbi gamma-Aminobutyric acid (GABA) signaling components in Drosophila: immunocytochemical localization of GABA(B) receptors in relation to the GABA(A) receptor subunit RDL and a vesicular GABA transporter
    Lina Enell
    Department of Zoology, Stockholm University, SE 106 91 Stockholm, Sweden
    J Comp Neurol 505:18-31. 2007
    gamma-Aminobutyric acid (GABA) is a major inhibitory neurotransmitter in insects and is widely distributed in the central nervous system (CNS)...
  21. pmc GABAA receptor RDL inhibits Drosophila olfactory associative learning
    Xu Liu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 56:1090-102. 2007
    ..The GABAA receptor, resistance to dieldrin (Rdl), is highly expressed in the Drosophila mushroom bodies (MBs), a group of neurons playing essential ..
  22. pmc Glutamate, GABA and acetylcholine signaling components in the lamina of the Drosophila visual system
    Agata Kolodziejczyk
    Department of Zoology, Stockholm University, Stockholm, Sweden
    PLoS ONE 3:e2110. 2008
    ..combined Gal4 driven green fluorescent protein in specific lamina neurons with antisera to gamma-aminobutyric acid (GABA), glutamic acid decarboxylase, a GABA(B) type of receptor, L-glutamate, a vesicular glutamate transporter (vGluT), ..
  23. pmc The GABAA receptor RDL suppresses the conditioned stimulus pathway for olfactory learning
    Xu Liu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 29:1573-9. 2009
    ..Prior studies have shown that the GABA receptor RDL inhibits aversive olfactory learning via its role in the Drosophila mushroom bodies (MBs)...
  24. doi Gamma-aminobutyric acid (GABA)-mediated neural connections in the Drosophila antennal lobe
    Ryuichi Okada
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Comp Neurol 514:74-91. 2009
    Inhibitory synaptic connections mediated by gamma-aminobutyric acid (GABA) play important roles in the neural computation of the brain...
  25. doi Splice-variant- and stage-specific RNA editing of the Drosophila GABA receptor modulates agonist potency
    Andrew K Jones
    Medical Research Council, Functional Genomics Unit, University of Oxford, Oxford OX1 3QX, United Kingdom
    J Neurosci 29:4287-92. 2009
    ..Using RDL, a Drosophila melanogaster GABA-gated ion channel, we examined the functional impact of RNA editing at several sites along with alternative ..
  26. pmc Adenosine-to-inosine genetic recoding is required in the adult stage nervous system for coordinated behavior in Drosophila
    James E C Jepson
    Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912, USA
    J Biol Chem 284:31391-400. 2009
    ....
  27. pmc Molecular characterization of agonists that bind to an insect GABA receptor
    Ian McGonigle
    Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK
    Biochemistry 49:2897-902. 2010
    ..One of the most widely studied insect GABA receptors is constructed from RDL (resistance to dieldrin) subunits from Drosophila melanogaster...
  28. pmc Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects
    Liam P Keegan
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Nucleic Acids Res 39:7249-62. 2011
    ..The ADAR1 gene has been lost several times, including during the evolution of insects and crustacea. These data complement our rescue results, supporting the idea that ADAR1 and ADAR2 have evolved highly conserved, distinct functions...
  29. pmc Molecular cloning and transformation of cyclodiene resistance in Drosophila: an invertebrate gamma-aminobutyric acid subtype A receptor locus
    R H ffrench-Constant
    Department of Entomology, Russell Laboratories, University of Wisconsin, Madison 53706
    Proc Natl Acad Sci U S A 88:7209-13. 1991
    ..To our knowledge, this represents the first cloning of an invertebrate GABA receptor and also allows us to manipulate the resistance status of an insect via germ-line transformation...
  30. ncbi Stable expression of a functional homo-oligomeric Drosophila GABA receptor in a Drosophila cell line
    N S Millar
    Wellcome Laboratory of Molecular Pharmacology, Department of Pharmacology, University College London, U K
    Proc Biol Sci 258:307-14. 1994
    A cloned Drosophila gamma-aminobutyric acid GABA receptor subunit (Rdl) has been stably expressed as a functional homo-oligomeric ion channel in a Drosophila cell line...
  31. ncbi Immunocytochemical mapping of a C-terminus anti-peptide antibody to the GABA receptor subunit, RDL in the nervous system in Drosophila melanogaster
    J B Harrison
    Babraham Institute Laboratory of Molecular Signalling, Cambridge, UK
    Cell Tissue Res 284:269-78. 1996
    ..on the C-terminal derived amino acid sequence from a cloned Drosophila melanogaster (fruit fly) gene, Rdl (resistant to dieldrin), was used to investigate localization of a GABA receptor subunit in adult male D. melanogaster...
  32. ncbi Evolution of Drosophila insecticide resistance
    R A Morton
    Department of Biology, McMaster University, Hamilton, Ont, Canada
    Genome 36:1-7. 1993
    ..In addition, molecular genetic techniques developed using Drosophila can eventually be transferred to other insects in order to help control pest populations...
  33. ncbi Stable expression of insect GABA receptors in insect cell lines. Promoters for efficient expression of Drosophila and mosquito Rdl GABA receptors in stably transformed mosquito cell lines
    F Shotkoski
    Department of Neuroscience, University of Wisconsin Madison, 53706, USA
    FEBS Lett 380:257-62. 1996
    ..insect cell lines efficiently expressing the insect gamma-aminobutyric acid (GABA) receptor subunit gene Resistance to dieldrin or Rdl...
  34. pmc Modulation of a recombinant invertebrate gamma-aminobutyric acid receptor-chloride channel complex by isoflurane: effects of a point mutation in the M2 domain
    M D Edwards
    Department of Academic Anaesthetics, Imperial College of Science, Technology and Medicine, at St Mary s Hospital Medical School, London
    Br J Pharmacol 122:726-32. 1997
    ..In this paper we address submolecular mechanisms for gamma-aminobutyric acid (GABA) receptor modulation by isoflurane. 2...
  35. ncbi graal: a Drosophila gene coding for several mosaic serine proteases
    Anne Isabelle Munier
    Institut de Biologie Moleculaire et Cellulaire, CNRS UPR 9022, 15 rue Descartes, 67084 Strasbourg, France
    Insect Biochem Mol Biol 34:1025-35. 2004
    ..However, no phenotype could be observed consecutive to the absence of graal full length transcripts, particularly in the context of an immune challenge...
  36. pmc The GABA(A) receptor RDL acts in peptidergic PDF neurons to promote sleep in Drosophila
    Brian Y Chung
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Curr Biol 19:386-90. 2009
    ..We find that RNA interference-mediated knockdown of the GABA(A) receptor gene, Resistant to dieldrin (Rdl), in PDF neurons reduces sleep, consistent with a role for GABA in inhibiting PDF neuron function...
  37. doi Gustatory habituation in Drosophila relies on rutabaga (adenylate cyclase)-dependent plasticity of GABAergic inhibitory neurons
    Pushkar Paranjpe
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India
    Learn Mem 19:627-35. 2012
    ..b>GABA synthesis in and release from glutamic acid decarboxylase (GAD1) expressing neurons is necessary, and GABA(A) ..
  38. pmc Suppression of inhibitory GABAergic transmission by cAMP signaling pathway: alterations in learning and memory mutants
    Archan Ganguly
    Department of Biological Sciences, Neuroscience Program, Ohio University, 213 Life Science Building, Athens, OH, 45701, USA
    Eur J Neurosci 37:1383-93. 2013
    ..PKA acts through the modulation of ionotropic GABA receptor sensitivity to the neurotransmitter GABA...
  39. doi Drosophila neuroligin 4 regulates sleep through modulating GABA transmission
    Yi Li
    Institute of Life Sciences, The Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China and Neurosciences and Mental Health Program, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada M5S 1A1
    J Neurosci 33:15545-54. 2013
    ..b>GABA transmission is impaired in mutant l-LNv, and sleep defects in dnlg4 mutant flies can be rescued by genetic ..
  40. pmc Short neuropeptide F is a sleep-promoting inhibitory modulator
    Yuhua Shang
    National Center for Behavioral Genomics and Department of Biology, Brandeis University, Waltham, MA 02454, USA
    Neuron 80:171-83. 2013
    ..sNPF acutely increases sleep without altering feeding behavior, which it affects only on a much longer time scale. The profound effect of sNPF on sleep indicates that it is an important sleep-promoting molecule. ..
  41. pmc WIDE AWAKE mediates the circadian timing of sleep onset
    Sha Liu
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
    Neuron 82:151-66. 2014
    ..WAKE interacts with the GABAA receptor Resistant to Dieldrin (RDL), upregulating its levels and promoting its localization to the plasma membrane...
  42. doi Insights into GABAAergic system deficits in fragile X syndrome lead to clinical trials
    Sien Braat
    Department of Medical Genetics, University of Antwerp, Prins Boudewijnlaan 43, 2650 Edegem, Antwerp, Belgium Electronic address
    Neuropharmacology 88:48-54. 2015
    ..mice, including altered expression of various components, aberrant GABAA receptor-mediated signalling, altered GABA concentrations and anatomical defects in GABAergic neurons...
  43. pmc A pentasymmetric open channel blocker for Cys-loop receptor channels
    Valentina Carta
    Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland
    PLoS ONE 9:e106688. 2014
    ..Interestingly, other anion selective cys-loop receptors were also inhibited by PCCP-, among them the Drosophila RDL GABAA receptor carrying an insecticide resistance mutation, suggesting that PCCP- could serve as an insecticide.
  44. pmc Learning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach us
    Ana Rita Santos
    VIB Center for the Biology of Disease, 3000 Leuven, Belgium Center for Human Genetics, KU Leuven, 3000 Leuven, Belgium Leuven Institute for Neurodegenerative Diseases LIND, KU Leuven, 3000 Leuven, Belgium
    Learn Mem 21:543-55. 2014
    ..Additionally, we discuss several potential treatments under study in animal models that are able to partially revert some of the FXS abnormalities. ..
  45. pmc A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster
    Paula R Haynes
    Department of Biology, Volen Center for Complex Systems, National Center for Behavioral Genomics, Brandeis University, Waltham, United States
    elife 4:. 2015
    ..DPMs increase sleep via release of GABA onto wake-promoting mushroom body (MB) α'/β' neurons...
  46. doi Novel GABA receptor pesticide targets
    John E Casida
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy, and Management, University of California, Berkeley, California 94720 3112, United States Electronic address
    Pestic Biochem Physiol 121:22-30. 2015
    The γ-aminobutyric acid (GABA) receptor has four distinct but overlapping and coupled targets of pesticide action importantly associated with little or no cross-resistance...
  47. pmc Modification of Male Courtship Motivation by Olfactory Habituation via the GABAA Receptor in Drosophila melanogaster
    Shin Ichiro Tachibana
    Career Path Promotion Unit for Young Life Scientists, Kyoto University, Kyoto, 606 8501, Japan Department of Biology and Geosciences, Graduate School of Science, Osaka City University, Osaka, 558 8585, Japan
    PLoS ONE 10:e0135186. 2015
    ..In contrast, transgenic males, in which GABA input in a small subset of local neurons was blocked by RNAi, failed to acquire the sexual advantage conferred by ..
  48. pmc Exaggerated Nighttime Sleep and Defective Sleep Homeostasis in a Drosophila Knock-In Model of Human Epilepsy
    EMILY PETRUCCELLI
    Interdisciplinary Program in Genetics, University of Iowa, Iowa City, IA, United States of America
    PLoS ONE 10:e0137758. 2015
    ..GEFS+ mutant sleep phenotypes were more resistant to pharmacologic reduction of GABA transmission by carbamazepine (CBZ) than controls, and were mitigated by reducing GABAA receptor expression ..
  49. pmc Determining exon connectivity in complex mRNAs by nanopore sequencing
    Mohan T Bolisetty
    Department of Genetics and Genome Sciences, Institute for Systems Genomics, University of Connecticut Health Center, Farmington, CT, 06030, USA
    Genome Biol 16:204. 2015
    ..sequencer to identify 7,899 'full-length' isoforms expressed from four Drosophila genes, Dscam1, MRP, Mhc, and Rdl. These results demonstrate that nanopore sequencing can be used to deconvolute individual isoforms and that it has ..
  50. ncbi Replacement of asparagine with arginine at the extracellular end of the second transmembrane (M2) region of insect GABA receptors increases sensitivity to penicillin G
    Alastair M Hosie
    Department of Pharmacology, University College, Gower St, London WC1E 6BT, UK
    Invert Neurosci 6:75-9. 2006
    ..The A301S mutation that confers resistance to dieldrin did not significantly affect the antagonism by PCG.
  51. ncbi Decreased expression of the GABAA receptor in fragile X syndrome
    Charlotte D'Hulst
    Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
    Brain Res 1121:238-45. 2006
    ..melanogaster) model we also found almost 50% under expression of all 3 subunits which make up the invertebrate GABA receptor, namely Grd, Rdl and Lcch3...
  52. ncbi Development of a Drosophila seizure model for in vivo high-throughput drug screening
    Geoff E Stilwell
    Cambria Biosciences, 8A Henshaw St, Woburn, MA 01801, USA
    Eur J Neurosci 24:2211-22. 2006
    ..screening for antiepileptic drug candidates, we characterized a Drosophila chemical treatment model using the GABA(A) receptor antagonist picrotoxin...
  53. pmc Engineered alterations in RNA editing modulate complex behavior in Drosophila: regulatory diversity of adenosine deaminase acting on RNA (ADAR) targets
    James E C Jepson
    Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island 02912, USA
    J Biol Chem 286:8325-37. 2011
    ..Our data demonstrate that network-wide temporal and spatial regulation of ADAR activity can tune the complex system of RNA-editing sites and modulate multiple ethologically relevant behavioral modalities...
  54. ncbi Drosophila cyclodiene resistance gene shows conserved genomic organization with vertebrate gamma-aminobutyric acidA receptors
    R H ffrench-Constant
    Entomology Department, University of Wisconsin, Madison 53706
    J Neurochem 59:1562-5. 1992
    Genomic clones from the Rdl locus of Drosophila, whose mutant phenotype is resistant to cyclodiene insecticides and picrotoxin, were characterized by restriction mapping and partial sequencing to determine intron/exon structure...
  55. pmc Detection of DNA domains in Drosophila, human, and plant chromosomes possessing mainly 50- to 150-kilobase stretches of DNA
    N A Tchurikov
    Department of Genome Organization, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow
    Proc Natl Acad Sci U S A 89:6751-5. 1992
    ..We propose that f-DNA segments may correspond to some regular higher-order structures in the eukaryotic chromosomes...
  56. ncbi Gene mapping and cross-resistance in cyclodiene insecticide-resistant Drosophila melanogaster (Mg.)
    R H ffrench-Constant
    Department of Entomology, Cornell University, Ithaca, N Y 14853
    Genet Res 57:17-21. 1991
    Resistance to the cyclodiene insecticide dieldrin maps to a single gene (Rdl) on the left arm of chromosome III in Drosophila melanogaster (Meigen)...
  57. ncbi GABA receptor minigene rescues insecticide resistance phenotypes in Drosophila
    G E Stilwell
    Department of Entomology, Russell Laboratories, Madison, WI 53706, USA
    J Mol Biol 253:223-7. 1995
    A single point mutation within the GABA receptor gene Resistance to dieldrin (Rdl) confers a high level of resistance to cyclodiene insecticides in a wide range of insects...
  58. ncbi Actions of picrotoxinin analogues on an expressed, homo-oligomeric GABA receptor of Drosophila melanogaster
    Y Shirai
    Graduate School of Science and Technology, Kobe University, Hyogo Japan
    Neurosci Lett 189:1-4. 1995
    ..on a Drosophila melanogaster homo-oligomeric GABA (gamma-aminobutyric acid) receptor formed when RDL (resistance to dieldrin) subunits were expressed in Xenopus oocytes...
  59. ncbi Drosophila GABA-gated chloride channel: modified [3H]EBOB binding site associated with Ala-->Ser or Gly mutants of Rdl subunit
    L M Cole
    Department of Environmental Science, Policy and Management, University of California, Berkeley 94720 3112
    Life Sci 56:757-65. 1995
    ..melanogaster has been attributed to a mutation resulting in an Ala302-->Ser replacement in the Rdl GABA receptor subunit and in D. simulans to an homologous Ala-->Ser or Gly replacement...
  60. ncbi Actions of agonists and convulsant antagonists on a Drosophila melanogaster GABA receptor (Rdl) homo-oligomer expressed in Xenopus oocytes
    S D Buckingham
    Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, UK
    Neurosci Lett 181:137-40. 1994
    ..injection of Xenopus oocytes with cDNA-derived RNA (cRNA) encoding a wild-type Drosophila melanogaster GABA receptor subunit (Rdl) resulted in functional expression of a GABA receptor homo-oligomer...
  61. ncbi The molecular and population genetics of cyclodiene insecticide resistance
    R H ffrench-Constant
    Department of Entomology, University of Wisconsin Madison 53706
    Insect Biochem Mol Biol 24:335-45. 1994
    ..The cyclodiene resistance gene Rdl (resistance to dieldrin) was cloned from a mutant of the model insect Drosophila resistant to cyclodienes and picrotoxinin...
  62. ncbi PCR-based homology probing reveals a family of GABA receptor-like genes in Drosophila melanogaster
    J E Henderson
    New York State Agricultural Experiment Station, Cornell University, Geneva 14456
    Insect Biochem Mol Biol 24:363-71. 1994
    ..genomic DNA for sequences encoding a conserved amino acid 'signature motif' known to be present in vertebrate GABA receptor and glycine receptor subunit genes...
  63. ncbi Expression of a Drosophila GABA receptor in a baculovirus insect cell system. Functional expression of insecticide susceptible and resistant GABA receptors from the cyclodiene resistance gene Rdl
    H J Lee
    Department of Entomology, University of Wisconsin Madison 53706
    FEBS Lett 335:315-8. 1993
    Recombinant baculoviruses containing two alternative splice forms of the Drosophila Rdl GABA receptor gene were constructed. Spodoptera frugiperda (Sf21) cells infected with either splice form expressed a transcript of expected size (2...
  64. ncbi Cloning and sequencing of the cyclodiene insecticide resistance gene from the yellow fever mosquito Aedes aegypti. Conservation of the gene and resistance associated mutation with Drosophila
    M Thompson
    Entomology Department, University of Wisconsin Madison 53706
    FEBS Lett 325:187-90. 1993
    ..between species we cloned a cDNA from the yellow fever mosquito Aedes aegypti homologous to the resistance gene Rdl in Drosophila. In D...
  65. ncbi Blocking actions of BIDN, a bicyclic dinitrile convulsant compound, on wild-type and dieldrin-resistant GABA receptor homo-oligomers of Drosophila melanogaster expressed in Xenopus oocytes
    A M Hosie
    Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, UK
    Brain Res 693:257-60. 1995
    ..BIDN was found to be less effective against a mutant (A(302) --> S) form of the receptor resistant to dieldrin and picrotoxinin...
  66. ncbi Functional analysis of a mosquito gamma-aminobutyric acid receptor gene promoter
    F Shotkoski
    Department of Neurobiology, University of Wisconsin Madison 53706, USA
    Gene 168:127-33. 1996
    A single point mutation in the insect gamma-aminobutyric acid receptor (GABAR)-encoding gene (Rdl) confers high levels of resistance to cyclodienes in Drosophila and other insects...
  67. ncbi pH-dependent actions of THIP and ZAPA on an ionotropic Drosophila melanogaster GABA receptor
    K Matsuda
    Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, UK
    Brain Res 739:335-8. 1996
    ..and ZAPA (Z-3-[(aminoiminomethyl)thio]prop-2-enoic acid) were tested on an ionotropic homo-oligomeric GABA receptor of Drosophila melanogaster...
  68. ncbi Wild-type and insecticide-resistant homo-oligomeric GABA receptors of Drosophila melanogaster stably expressed in a Drosophila cell line
    S D Buckingham
    Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, UK
    Neuropharmacology 35:1393-401. 1996
    RDL is an ionotropic GABA receptor subunit, a product of the Rdl gene, originally identified in the Maryland strain of Drosophila melanogaster...
  69. ncbi Conservation of cyclodiene insecticide resistance-associated mutations in insects
    M Thompson
    Department of Entomology, University of Wisconsin Madison 53706, USA
    Insect Mol Biol 2:149-54. 1993
    ..In Drosophila melanogaster resistance is associated with a single base pair substitution in the GABA receptor/chloride ion channel gene Rdl...
  70. ncbi Immunocytochemistry of a novel GABA receptor subunit Rdl in Drosophila melanogaster
    K Aronstein
    Department of Entomology, University of Wisconsin Madison 53706, USA
    Invert Neurosci 1:25-31. 1995
    Following our recent cloning of a novel gamma-aminobutyric acid (GABA) receptor subunit gene Resistance to dieldrin or Rdl form cyclodiene resistance locus in Drosophila melanogaster, we were interested in defining its pattern of ..
  71. ncbi Distribution of two GABA receptor-like subunits in the Drosophila CNS
    K Aronstein
    Department of Neuroscience, University of Wisconsin Madison, Russell Laboratories 53706, USA
    Invert Neurosci 2:115-20. 1996
    Previously we have described the distribution of the Rdl GABA receptor subunit in the Drosophila CNS...
  72. ncbi Identification of major phylogenetic branches of inhibitory ligand-gated channel receptors
    H Xue
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong
    J Mol Evol 47:323-33. 1998
    ..Branch IIIB, composed of invertebrate GluCl receptors, to form Branch III, which is designated NA for being non-GABA responsive. Branch IV is called UD for being undefined in specificity...
  73. ncbi Diversification of Drosophila chloride channel gene by multiple posttranscriptional mRNA modifications
    E P Semenov
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    J Neurochem 72:66-72. 1999
    ..These results give the first example of RNA editing in neurotransmitter-gated chloride channel genes or of alternative splicing in a glutamate-gated chloride channel gene of Drosophila...
  74. pmc Why are there so few resistance-associated mutations in insecticide target genes?
    R H ffrench-Constant
    Department of Entomology, University of Wisconsin Madison 53706, USA
    Philos Trans R Soc Lond B Biol Sci 353:1685-93. 1998
    The genes encoding the three major targets of conventional insecticides are: Rdl, which encodes a gamma-aminobutyric acid receptor subunit (RDL); para, which encodes a voltage-gated sodium channel (PARA); and Ace, which encodes insect ..
  75. pmc Cation permeability and cation-anion interactions in a mutant GABA-gated chloride channel from Drosophila
    C T Wang
    Department of Physiology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Biophys J 77:691-700. 1999
    To investigate the structural basis of anion selectivity of Drosophila GABA-gated Cl(-) channels, the permeation properties of wild-type and mutant channels were studied in Xenopus oocytes...
  76. pmc Cross-resistance with dieldrin of a novel tricyclic dinitrile GABA receptor antagonist
    K Matsuda
    The Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, USA
    Br J Pharmacol 127:1305-7. 1999
    ..tricyclic dinitrile, KN244, blocked the wild-type (dieldrin-sensitive) homo-oligomeric gamma-aminobutyric acid (GABA)-gated chloride channel of Drosophila melanogaster expressed in Xenopus oocytes...
  77. ncbi The pharmacological flexibility of the insect voltage gated sodium channel: toxicity of AaIT to knockdown resistant (kdr) flies
    E Zlotkin
    Merck Research Laboratories, Rahway, NJ, USA
    Insect Biochem Mol Biol 29:849-53. 1999
    ..The above data are interpreted in terms of the pharmacological diversity and flexibility ("allosteric coupling") of voltage gated sodium channels and their implications for the management of pesticide resistance are discussed...
  78. pmc Alpha-thujone (the active component of absinthe): gamma-aminobutyric acid type A receptor modulation and metabolic detoxification
    K M Höld
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, 114 Wellman Hall, University of California, Berkeley, CA 94720 3112, USA
    Proc Natl Acad Sci U S A 97:3826-31. 2000
    ..Four observations establish that alpha-thujone is a modulator of the gamma-aminobutyric acid (GABA) type A receptor...
  79. ncbi Dbeta3, an atypical nicotinic acetylcholine receptor subunit from Drosophila : molecular cloning, heterologous expression and coassembly
    Stuart J Lansdell
    Department of Pharmacology, University College London, London, UK
    J Neurochem 80:1009-18. 2002
    ....
  80. ncbi The target of Drosophila photoreceptor synaptic transmission is a histamine-gated chloride channel encoded by ort (hclA)
    Chaoxian Gengs
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 277:42113-20. 2002
    ..Moreover, the present work shows that this function of the HCLA (ORT) protein is its native function in vivo...
  81. ncbi A Drosophila melanogaster cell line (S2) facilitates post-genome functional analysis of receptors and ion channels
    Paula R Towers
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, UK
    Bioessays 24:1066-73. 2002
    ..In addition, many useful orthologues of human disease genes are emerging from the Drosophila genome and the study of their functions and interactions is another area for postgenome applications of S2 cell lines...
  82. ncbi Drugs, flies, and videotape: the effects of ethanol and cocaine on Drosophila locomotion
    Adrian Rothenfluh
    Department of Anatomy, University of California at San Francisco, 513 Parnassus Avenue, 94143 0452, USA
    Curr Opin Neurobiol 12:639-45. 2002
    ..Surprising similarities between flies and mammals have begun to emerge at the behavioral, neurochemical and molecular levels...
  83. ncbi Charting the Drosophila neuropile: a strategy for the standardised characterisation of genetically amenable neurites
    Matthias Landgraf
    Department of Zoology, Downing Street, CB2 3EJ, Cambridge, UK
    Dev Biol 260:207-25. 2003
    ..Using the Fasciclin2-based mapping procedure as a standard (e.g., in a common database) would facilitate studies on the functional architecture of the neuropile and the identification of candiate circuit elements...
  84. ncbi Evolutionary convergence of alternative splicing in ion channels
    Richard R Copley
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Trends Genet 20:171-6. 2004
    ..The result has important implications for the analysis of regulation of alternative splicing using comparative genomics and our understanding of molecular evolution...
  85. ncbi The influence of pioneer neurons on a growing motor nerve in Drosophila requires the neural cell adhesion molecule homolog FasciclinII
    Natalia Sánchez-Soriano
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, United Kingdom
    J Neurosci 25:78-87. 2005
    ..Therefore, FasciclinII is to a degree required and sufficient for pioneer-follower interactions, but its mode of action cannot be explained merely through an equally bidirectional adhesive interaction...
  86. ncbi Phylogenetic shadowing of a histamine-gated chloride channel involved in insect vision
    Mladen Iovchev
    Institute of Molecular Biology, Department of Molecular Neurobiology, Sofia 1113, Bulgaria
    Insect Biochem Mol Biol 36:10-7. 2006
    ..Real-time PCR analysis demonstrated that hclA-mRNA is abundant in heads of adult Drosophila. However, species- and sex-specific variations of the hclA expression levels were also observed...
  87. ncbi Mutations in the K+/Cl- cotransporter gene kazachoc (kcc) increase seizure susceptibility in Drosophila
    Daria S Hekmat-Scafe
    Department of Environmental Science, Policy and Management, Division of Insect Biology, University of California, Berkeley, California 94720, USA
    J Neurosci 26:8943-54. 2006
    ..The developmental GABA switch is mediated primarily by KCC2, a neuronal K+/Cl- cotransporter that determines the intracellular ..
  88. ncbi Molecular cloning of a GABA receptor subunit from Laodelphax striatella (Fallén) and patch clamp analysis of the homo-oligomeric receptors expressed in a Drosophila cell line
    K Narusuye
    Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane University, Matsue, Shimane, Japan
    Insect Mol Biol 16:723-33. 2007
    ..The L. striatella GABA receptor subunit was found to have high amino acid sequence similarity to the bd-type splice variant of the Drosophila ..
  89. pmc Modulation of GABAA receptor desensitization uncouples sleep onset and maintenance in Drosophila
    Jose Agosto
    Howard Hughes Medical Institute, Brandeis University, 415 South St, Waltham, Massachusetts 02454 9110, USA
    Nat Neurosci 11:354-9. 2008
    Many lines of evidence indicate that GABA and GABA(A) receptors make important contributions to human sleep regulation. Pharmacological manipulation of these receptors has differential effects on sleep onset and sleep maintenance insomnia...
  90. pmc Dynein-dynactin complex is essential for dendritic restriction of TM1-containing Drosophila Dscam
    Jacob Shun Jen Yang
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA, USA
    PLoS ONE 3:e3504. 2008
    ..Many membrane proteins, including Drosophila Dscam, are enriched in dendrites or axons within neurons. However, little is known about how the differential distribution is established and maintained...
  91. doi A map of octopaminergic neurons in the Drosophila brain
    Sebastian Busch
    Lehrstuhl für Genetik und Neurobiologie, Universitat Wurzburg, Germany
    J Comp Neurol 513:643-67. 2009
    ..The map may provide an anatomical framework for the functional constitution of the octopaminergic system. It also serves as a model for the single-cell organization of a particular neurotransmitter in the brain...
  92. ncbi Subunit composition determines picrotoxin and bicuculline sensitivity of Drosophila gamma-aminobutyric acid receptors
    H G Zhang
    Department of Physiology, University of Wisconsin Madison 53706, USA
    Mol Pharmacol 48:835-40. 1995
    Few gamma-aminobutyric acid (GABA) receptor subunits have been cloned from insects. These include Resistance to dieldrin, or Rdl, and a homologue of the vertebrate GABAA receptor beta subunit...
  93. pmc Actions of the insecticide fipronil, on dieldrin-sensitive and- resistant GABA receptors of Drosophila melanogaster
    A M Hosie
    Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, Cambridge
    Br J Pharmacol 115:909-12. 1995
    ..forms of the Drosophila melanogaster GABA-gated chloride channel homo-oligomer, RDL (the product of the resistance to dieldrin locus: Rdl). 2...
  94. ncbi Drosophila gamma-aminobutyric acid receptor gene Rdl shows extensive alternative splicing
    R H ffrench-Constant
    Department of Entomology, University of Wisconsin Madison 53706
    J Neurochem 60:2323-6. 1993
    ..All possible combinations of exons (a with c or d and b with c or d) were found in RNA isolated from early embryos. This is the first demonstration of alternative splicing in a GABA receptor gene from invertebrates.
  95. pmc Cloning and functional expression of a Drosophila gamma-aminobutyric acid receptor
    R Chen
    CoCensys, Inc, Irvine, CA 92718
    Proc Natl Acad Sci U S A 91:6069-73. 1994
    A cDNA encoding a functional gamma-aminobutyric (GABA)-activated Cl- channel has been isolated from an adult Drosophila head cDNA library...
  96. ncbi Cloning of a putative GABAA receptor from cyclodiene-resistant Drosophila: a case study in the use of insecticide-resistant mutants to isolate neuroreceptors
    R H ffrench-Constant
    University of Wisconsin Madison 53706
    EXS 63:210-23. 1993
    ..Thus examination of resistance-associated mutations in this receptor in a range of species will enhance our understanding of both the binding sites of toxic ligands and the genetic basis of pesticide resistance...
  97. pmc Actions of picrodendrin antagonists on dieldrin-sensitive and -resistant Drosophila GABA receptors
    A M Hosie
    Department of Zoology, University of Cambridge, UK
    Br J Pharmacol 119:1569-76. 1996
    ..related terpenoids have been assayed on homooligomeric GABA receptors formed by the expression of a Drosophila GABA receptor subunit (RDLac) in Xenopus oocytes. 2...
  98. pmc Molecular architecture of the hsp70 promoter after deletion of the TATA box or the upstream regulation region
    J A Weber
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park 16802, USA
    Mol Cell Biol 17:3799-808. 1997
    ..GAGA factor alone might be capable of establishing an open chromatin structure that encompasses the upstream regulatory region as well as the core promoter region, thus facilitating the binding of TFIID...
  99. pmc Effects of [3H]-BIDN, a novel bicyclic dinitrile radioligand for GABA-gated chloride channels of insects and vertebrates
    J J Rauh
    DuPont Agricultural Products, Stine Haskell Research Center, Newark, DE 19714, USA
    Br J Pharmacol 121:1496-505. 1997
    ..5. Expression in Xenopus oocytes of either rat brain mRNA, or cDNA-derived RNA encoding a GABA receptor subunit (Rdl) that is expressed widely in the nervous system of Drosophila melanogaster resulted in functional,..
  100. ncbi A current perspective on insect gene transformation
    A M Handler
    Center for Medical, Agricultural, and Veterinary Entomology, Agricultural Research Service, US Department of Agriculture, 1700 S W 23rd Drive, Gainesville, FL 32608, USA
    Insect Biochem Mol Biol 31:111-28. 2001
    ....
  101. ncbi Using Drosophila as a model insect
    D Schneider
    Whitehead Institute, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Rev Genet 1:218-26. 2000
    ..Specifically, I discuss recent work on the use of Drosophila to study the transmission of disease by insect vectors and to investigate insecticide function and development...

Research Grants1

  1. A TOXIN BASED DROSOPHILA PARKINSON'S DISEASE MODEL
    Geoffrey Stilwell; Fiscal Year: 2005
    ....