Rab11

Summary

Gene Symbol: Rab11
Description: CG5771 gene product from transcript CG5771-RA
Alias: AAF55850, CG5771, DRAB11, DRab11, Dm Rab11, DmRab11, Dmel\CG5771, Drab11, O18335, RAB11, Rab 11, Rab-11, Rab-r11, dRab11, l(3)93Bi, l(3)j2D1, rab-11, rab11, rlr7, CG5771 gene product from transcript CG5771-RA, CG5771-PA, CG5771-PB, Rab-protein 11, Rab11-PA, Rab11-PB, lethal(3)93Bi
Species: fruit fly

Top Publications

  1. ncbi Molecular cloning of the UMP synthase gene rudimentary-like from Drosophila melanogaster
    M Eisenberg
    T H Morgan School of Biological Sciences, University of Kentucky, Lexington 40506
    Mol Gen Genet 222:1-8. 1990
  2. pmc Drosophila spichthyin inhibits BMP signaling and regulates synaptic growth and axonal microtubules
    Xinnan Wang
    Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK
    Nat Neurosci 10:177-85. 2007
  3. doi Mutation in Rab11 results in abnormal organization of ommatidial cells and activation of JNK signaling in the Drosophila eye
    Anand K Tiwari
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Eur J Cell Biol 88:445-60. 2009
  4. ncbi Rab11 polarization of the Drosophila oocyte: a novel link between membrane trafficking, microtubule organization, and oskar mRNA localization and translation
    Gretchen Dollar
    Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA
    Development 129:517-26. 2002
  5. pmc Actin cytoskeleton remodeling during early Drosophila furrow formation requires recycling endosomal components Nuclear-fallout and Rab11
    Blake Riggs
    Deptartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    J Cell Biol 163:143-54. 2003
  6. ncbi Rab11 mediates post-Golgi trafficking of rhodopsin to the photosensitive apical membrane of Drosophila photoreceptors
    Akiko K Satoh
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Development 132:1487-97. 2005
  7. pmc Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells
    Slobodan Beronja
    Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    J Cell Biol 169:635-46. 2005
  8. ncbi Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system
    Gregory Emery
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Cell 122:763-73. 2005
  9. ncbi Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors
    Hamed Jafar-Nejad
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Dev Cell 9:351-63. 2005
  10. ncbi Rab11 is required during Drosophila eye development
    Debasmita P Alone
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, India
    Int J Dev Biol 49:873-9. 2005

Scientific Experts

Detail Information

Publications109 found, 100 shown here

  1. ncbi Molecular cloning of the UMP synthase gene rudimentary-like from Drosophila melanogaster
    M Eisenberg
    T H Morgan School of Biological Sciences, University of Kentucky, Lexington 40506
    Mol Gen Genet 222:1-8. 1990
    ..cDNA clones of the embryonic UMP synthase mRNA have been isolated and used to define the extent of genomic DNA sequences which encode the transcript. The embryonic RNA is approximately 1.75 kb in length...
  2. pmc Drosophila spichthyin inhibits BMP signaling and regulates synaptic growth and axonal microtubules
    Xinnan Wang
    Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK
    Nat Neurosci 10:177-85. 2007
    ....
  3. doi Mutation in Rab11 results in abnormal organization of ommatidial cells and activation of JNK signaling in the Drosophila eye
    Anand K Tiwari
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Eur J Cell Biol 88:445-60. 2009
    b>Rab11(mo), a P insertion line of Rab11 showed degenerated ommatidia and excess cell death in larval/pupal eyes...
  4. ncbi Rab11 polarization of the Drosophila oocyte: a novel link between membrane trafficking, microtubule organization, and oskar mRNA localization and translation
    Gretchen Dollar
    Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA
    Development 129:517-26. 2002
    ..Specifically, we show that alpha-adaptin and Rab11, which function critically in the endocytic pathways of all previously examined animal cells, are localized to ..
  5. pmc Actin cytoskeleton remodeling during early Drosophila furrow formation requires recycling endosomal components Nuclear-fallout and Rab11
    Blake Riggs
    Deptartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    J Cell Biol 163:143-54. 2003
    ..Nuf is a homologue of arfophilin-2, an ADP ribosylation factor effector that binds Rab11 and influences recycling endosome (RE) organization...
  6. ncbi Rab11 mediates post-Golgi trafficking of rhodopsin to the photosensitive apical membrane of Drosophila photoreceptors
    Akiko K Satoh
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Development 132:1487-97. 2005
    ..b>Rab11, a small GTPase implicated in membrane traffic, immunolocalizes to the trans-Golgi network, cytoplasmic vesicles ..
  7. pmc Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells
    Slobodan Beronja
    Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    J Cell Biol 169:635-46. 2005
    ..Furthermore, we show that Rab11 forms a complex with Sec5 and that Sec5 interacts with Sec6 suggesting that the exocyst is a Rab11 effector that ..
  8. ncbi Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system
    Gregory Emery
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Cell 122:763-73. 2005
    ..In pIIb, Delta passes through the recycling endosome which is marked by Rab 11. In pIIa, however, the recycling endosome does not form because the centrosome fails to recruit Nuclear fallout, a ..
  9. ncbi Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors
    Hamed Jafar-Nejad
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Dev Cell 9:351-63. 2005
    ..Based on the dynamic traffic of Sec15, its colocalization with the recycling endosomal marker Rab11, and the aberrant distribution of Rab11 in sec15 clones, we propose that a defect in Delta recycling causes cell ..
  10. ncbi Rab11 is required during Drosophila eye development
    Debasmita P Alone
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, India
    Int J Dev Biol 49:873-9. 2005
    In an effort to identify the role of Rab11, a small GTP binding protein, during Drosophila differentiation, phenotypic manifestations associated with different alleles of Rab11 were studied...
  11. ncbi Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane
    Johanna Langevin
    Polarité Cellulaire chez la drosophile, UMR 144, Paris, France
    Dev Cell 9:365-76. 2005
    ..exocyst components sec5, sec6, and sec15 in epithelial cells results in DE-Cad accumulation in an enlarged Rab11 recycling endosomal compartment and inhibits DE-Cad delivery to the membrane...
  12. ncbi Endocytic control of epithelial polarity and proliferation in Drosophila
    Han Lu
    Department of Molecular and Cell Biology, University of California Berkeley, 142 LSA 3200 Berkeley, CA 94720 3200 USA
    Nat Cell Biol 7:1232-9. 2005
    ..Our findings reveal a critical and specific role for endocytic traffic in the control of both apico-basal polarity and cell proliferation...
  13. ncbi Hexagonal packing of Drosophila wing epithelial cells by the planar cell polarity pathway
    Anne Kathrin Classen
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01309 Dresden, Germany
    Dev Cell 9:805-17. 2005
    ..grow and shrink, resulting in local neighbor exchanges, and Cadherin is actively endocytosed and recycled through Rab11 endosomes. Hexagonal packing depends on the activity of the planar cell polarity proteins...
  14. ncbi The endocytic pathway and formation of the Wingless morphogen gradient
    Eric Marois
    Max Planck Institute for Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany
    Development 133:307-17. 2006
    ..Thus, subcellular localization of Wingless along the apical-basal axis of receiving cells may be instrumental in shaping the Wingless gradient...
  15. pmc Drosophila melanogaster auxilin regulates the internalization of Delta to control activity of the Notch signaling pathway
    Elliott J Hagedorn
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    J Cell Biol 173:443-52. 2006
    ..Furthermore, the fact that auxilin is required for Notch signaling suggests that ligand endocytosis in the signal-sending cells needs to proceed past coat disassembly to activate Notch...
  16. pmc The NHR1 domain of Neuralized binds Delta and mediates Delta trafficking and Notch signaling
    Cosimo Commisso
    The Hospital for Sick Children, Program in Developmental Biology, University of Toronto, Toronto, Ontario, Canada M5G 1X8
    Mol Biol Cell 18:1-13. 2007
    ..Altogether, our data demonstrate that NHR domains can function in facilitating protein-protein interactions and in the case of Neuralized, mediate binding to its ubiquitination target, Delta...
  17. ncbi Bchs, a BEACH domain protein, antagonizes Rab11 in synapse morphogenesis and other developmental events
    Rita Khodosh
    Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue 68 230B, Cambridge, MA 02139, USA
    Development 133:4655-65. 2006
    ..Here we show that the Drosophila BEACH protein Bchs (Blue cheese) acts during development as an antagonist of Rab11, a small GTPase involved in vesicle trafficking...
  18. ncbi Polarized exocytosis and transcytosis of Notch during its apical localization in Drosophila epithelial cells
    Nobuo Sasaki
    Department of Biological Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278 8510, Japan
    Genes Cells 12:89-103. 2007
    ..N, but not Dl, formed a specific complex with DEcad in vivo. Finally, our results suggest that juxtacrine signaling in epithelia generally depends on the apicobasally polarized structure of epithelial cells...
  19. pmc Myosin V, Rab11, and dRip11 direct apical secretion and cellular morphogenesis in developing Drosophila photoreceptors
    Bingbing X Li
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    J Cell Biol 177:659-69. 2007
    ..We recently showed Drosophila Rab11 is essential for rhodopsin transport in developing photoreceptors and asked here if myosin V and the Drosophila ..
  20. pmc The concentration of Nuf, a Rab11 effector, at the microtubule-organizing center is cell cycle regulated, dynein-dependent, and coincides with furrow formation
    Blake Riggs
    Sinsheimer Laboratories, Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Cruz, CA 95064, USA
    Mol Biol Cell 18:3313-22. 2007
    ..Recycling endosome (RE)-derived vesicles are a key source of this membrane. Rab11, a small GTPase associated with the RE and involved in vesicle targeting, is required for elongation of the ..
  21. ncbi The Drosophila homolog of the Exo84 exocyst subunit promotes apical epithelial identity
    J Todd Blankenship
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    J Cell Sci 120:3099-110. 2007
    ..These results suggest that epithelial polarity in the Drosophila embryo is actively maintained by exocyst-dependent apical localization of the Crumbs transmembrane protein...
  22. ncbi Rab11 maintains connections between germline stem cells and niche cells in the Drosophila ovary
    Nicholas Bogard
    University of Kansas, Department of Molecular Biosciences, 1200 Sunnyside Avenue, Lawrence, KS 66045, USA
    Development 134:3413-8. 2007
    ..Here we show that the Rab11 GTPase is required in the ovary to maintain GSC-cap cell junctions and to anchor the fusome to the anterior cortex ..
  23. pmc Rab11 is required for membrane trafficking and actomyosin ring constriction in meiotic cytokinesis of Drosophila males
    Maria Grazia Giansanti
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Genetica e Biologia Molecolare, Universita di Roma La Sapienza, 00185 Rome, Italy
    Mol Biol Cell 18:5034-47. 2007
    b>Rab11 is a small GTPase that regulates several aspects of vesicular trafficking. Here, we show that Rab11 accumulates at the cleavage furrow of Drosophila spermatocytes and that it is essential for cytokinesis...
  24. ncbi Spermatocyte cytokinesis requires rapid membrane addition mediated by ARF6 on central spindle recycling endosomes
    Naomi Dyer
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Development 134:4437-47. 2007
    ..We propose that ARF6 promotes rapid recycling of endosomal membrane stores during cytokinesis, which is critical for rapid cleavage furrow ingression...
  25. pmc Cell-nonautonomous function of ceramidase in photoreceptor homeostasis
    Jairaj K Acharya
    Laboratory of Cell and Developmental Signaling, National Cancer Institute, Frederick, MD 21702, USA
    Neuron 57:69-79. 2008
    ..Furthermore, our results show that secreted ceramidase is internalized and localizes to endosomes. Our findings establish a role for a secreted sphingolipid enzyme in the regulation of photoreceptor structure and function...
  26. pmc Ribbon modulates apical membrane during tube elongation through Crumbs and Moesin
    Bilal E Kerman
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Biol 320:278-88. 2008
    ..Furthermore, the subapical localization of Rab11, a small GTPase associated with apical membrane delivery and rearrangement, is significantly diminished in ribbon ..
  27. doi Modulation of intracellular trafficking regulates cell intercalation in the Drosophila trachea
    Daniel D Shaye
    Institut de Biologia Molecular de Barcelona CSIC, C Baldiri Reixac 10, 08028 Barcelona, Spain
    Nat Cell Biol 10:964-70. 2008
    ..the role of trafficking in tracheal intercalation and show that it requires endocytosis, whereas it is opposed by Rab11-mediated recycling in the dorsal trunk...
  28. pmc Nuf, a Rab11 effector, maintains cytokinetic furrow integrity by promoting local actin polymerization
    Jian Cao
    Sinsheimer Laboratories, Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    J Cell Biol 182:301-13. 2008
    ..In the Drosophila melanogaster early embryo, Nuf (Nuclear fallout), a Rab11 effector which is essential for RE function, is required for F-actin and membrane integrity during furrow ..
  29. pmc Nervous wreck and Cdc42 cooperate to regulate endocytic actin assembly during synaptic growth
    Avital A Rodal
    The Picower Institute for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 28:8316-25. 2008
    ..Cdc42 function is associated with Rab11-dependent recycling endosomes, and we show that Rab11 colocalizes with Nwk at the NMJ...
  30. pmc Differential stability of flamingo protein complexes underlies the establishment of planar polarity
    Helen Strutt
    MRC Centre for Developmental and Biomedical Genetics and, Department of Biomedical Science, University of Sheffield, Western Bank, S10 2TN Sheffield, United Kingdom
    Curr Biol 18:1555-64. 2008
    ..The core polarity protein Flamingo (Fmi) localizes to both proximal and distal cell boundaries and is known to have asymmetric activity, but the molecular basis of this asymmetric activity is unknown...
  31. doi Drosophila Cip4 and WASp define a branch of the Cdc42-Par6-aPKC pathway regulating E-cadherin endocytosis
    Andrea Leibfried
    Institut Curie, Centre National de la Recherche, UMR 144, Equipe Polarité Cellulaire chez la Drosophile, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Curr Biol 18:1639-48. 2008
    ..A mechanism regulating E-Cadherin (E-Cad) exocytosis to the AJs has implicated proteins of the exocyst complex, but mechanisms regulating E-Cad endocytosis from the AJs remain less well understood...
  32. doi Rab11 is required for embryonic nervous system development in Drosophila
    Tanmay Bhuin
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India
    Cell Tissue Res 335:349-56. 2009
    ..When the dominant-negative or constitutively-active mutant DRab11 proteins are expressed in neurons, or when homozygous mutant Rab11 embryos are analyzed, defects are found in the ..
  33. doi Developmental expression of Rab11, a small GTP-binding protein in Drosophila epithelia
    Satish Sasikumar
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India
    Genesis 47:32-9. 2009
    ..Here we report developmental expression of Drosophila Rab11, a small GTP-binding protein, required for both endocytic recycling and exocytosis...
  34. pmc The SM protein Car/Vps33A regulates SNARE-mediated trafficking to lysosomes and lysosome-related organelles
    Mohammed A Akbar
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Mol Biol Cell 20:1705-14. 2009
    ..Consistent with a role in Car-mediated fusion, dSyntaxin16 is not restricted to Golgi membranes but also present on lysosomes...
  35. pmc The Drosophila BEACH family protein, blue cheese, links lysosomal axon transport with motor neuron degeneration
    Angeline Lim
    Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, California 95064, USA
    J Neurosci 29:951-63. 2009
    ..We suggest therefore that anterograde transport of lysosomes toward synaptic termini is a key factor in preventing motor neuron degeneration and that Bchs reveals a functional link between the lysosomal degradative pathway and transport...
  36. doi Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division
    F Coumailleau
    Department of Biochemistry, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland
    Nature 458:1051-5. 2009
    ....
  37. doi Rab11 is required for myoblast fusion in Drosophila
    Tanmay Bhuin
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, 221 005, India
    Cell Tissue Res 336:489-99. 2009
    b>Rab11, an evolutionarily conserved, ubiquitously expressed subfamily of small monomeric Rab GTPases, has been implicated in regulating vesicular trafficking through the recycling of endosomal compartment...
  38. pmc Distinct functions for Rho1 in maintaining adherens junctions and apical tension in remodeling epithelia
    Stephen J Warner
    Department of Medicine, Washington University, St Louis, MO 63110, USA
    J Cell Biol 185:1111-25. 2009
    ..In contrast, depletion of Rho1 in single cells decreases apical tension, and Rok and myosin are necessary, while Dia function also contributes, downstream of Rho1 to sustain apical cell tension...
  39. pmc The vacuolar proton pump, V-ATPase, is required for notch signaling and endosomal trafficking in Drosophila
    Yan Yan
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Dev Cell 17:387-402. 2009
    ..Our results demonstrate that Rbcn-3 affects Notch signaling and trafficking through regulating V-ATPase function, which implies that the acidification of an intracellular compartment in the receiving cells is crucial for signaling...
  40. pmc Rab11 helps maintain apical crumbs and adherens junctions in the Drosophila embryonic ectoderm
    Jeremiah F Roeth
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    PLoS ONE 4:e7634. 2009
    ..Tissue morphogenesis and organogenesis require that cells retain stable cell-cell adhesion while changing shape and moving. One mechanism to accommodate this plasticity in cell adhesion involves regulated trafficking of junctional proteins...
  41. pmc Dual roles for the Drosophila PI 4-kinase four wheel drive in localizing Rab11 during cytokinesis
    Gordon Polevoy
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada
    J Cell Biol 187:847-58. 2009
    ..completion of cytokinesis relies on addition of new membrane, and requires the recycling endosome regulator Rab11, which localizes to the midzone...
  42. pmc Endocytic internalization routes required for delta/notch signaling
    Sarah L Windler
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720 3200, USA
    Curr Biol 20:538-43. 2010
    ..cells can occur by clathrin-independent endocytosis, when endosomal entry is blocked, and when activity of Rab11 or its effectors is reduced, suggesting that Delta need not pass through a recognized recycling pathway to achieve ..
  43. pmc Neuralized promotes basal to apical transcytosis of delta in epithelial cells
    Najate Benhra
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 6061, Institut de Génétique et Développement de Rennes, Universite de Rennes 1, 35000 Rennes, France
    Mol Biol Cell 21:2078-86. 2010
    ....
  44. pmc Drosophila acinus encodes a novel regulator of endocytic and autophagic trafficking
    Adam S Haberman
    Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Development 137:2157-66. 2010
    ..Taken together, our data show that dacn encodes a regulator of endosomal and autophagosomal dynamics, modulating developmental signaling and the cellular response to starvation...
  45. pmc Drosophila Mtm and class II PI3K coregulate a PI(3)P pool with cortical and endolysosomal functions
    Michaella Velichkova
    Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 190:407-25. 2010
    ..The broad interactions between mtm and class II Pi3K68D suggest a novel strategy for rebalancing PI(3)P-mediated cell functions in MTM-related human disease...
  46. doi A direct and functional interaction between Go and Rab5 during G protein-coupled receptor signaling
    Vladimir Purvanov
    Department of Biology, University of Konstanz, Konstanz 78457, Germany
    Sci Signal 3:ra65. 2010
    ..Additionally, the recycling Rab GTPases Rab4 and Rab11 functioned in Fz- and G(o)-mediated signaling to favor planar cell polarity over canonical Wingless signaling...
  47. doi APC/C(Fzr/Cdh1)-dependent regulation of cell adhesion controls glial migration in the Drosophila PNS
    Marion Silies
    Institut fur Neurobiologie, Universitat Munster, Munster, Germany
    Nat Neurosci 13:1357-64. 2010
    ..This represents a simple mechanism by which a subcellular gradient of adhesiveness can coordinate glial migration with axonal growth...
  48. doi Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst
    Annabel Guichard
    Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0349, USA
    Nature 467:854-8. 2010
    ..Here we use Drosophila melanogaster to identify the Rab11/Sec15 exocyst, which acts at the last step of endocytic recycling, as a novel target of both EF and LF...
  49. doi AP-1 controls the trafficking of Notch and Sanpodo toward E-cadherin junctions in sensory organ precursors
    Najate Benhra
    CNRS UMR 6061 Institut de Génétique et Développement de Rennes, Universite de Rennes 1, 2 avenue du Professeur Bernard, 35000 Rennes, France
    Curr Biol 21:87-95. 2011
    ..Because AP-1 does not prevent endocytosis and recycling of the Notch ligand Delta, our data indicate that the DE-cadherin junctional domain may act as a launching pad through which endocytosed Notch ligand is trafficked for signaling...
  50. pmc Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's disease
    P Richards
    MRC Toxicology Unit, University of Leicester, Hodgkin Building, Lancaster Road, Leicester, UK
    Cell Death Differ 18:191-200. 2011
    ..lost in the proximity of htt aggregates because of functional defects in local endosomal recycling mediated by the Rab11 protein...
  51. doi IKKε regulates cell elongation through recycling endosome shuttling
    Tetsuhisa Otani
    Laboratory for Morphogenetic Signaling, RIKEN Center for Developmental Biology, Kobe, Hyogo 650 0047, Japan
    Dev Cell 20:219-32. 2011
    ..IKKɛ regulates the localization of recycling endosome regulators Rab11 and Dynein and phosphorylates their adaptor molecule, Nuclear fallout (Nuf)...
  52. pmc Auxilin is required for formation of Golgi-derived clathrin-coated vesicles during Drosophila spermatogenesis
    Xin Zhou
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907 2054, USA
    Development 138:1111-20. 2011
    ..Our data suggest that Aux participates in forming these Golgi-derived clathrin-positive vesicles and that Aux, therefore, has a role in the secretory pathway...
  53. pmc Rab11 is required for epithelial cell viability, terminal differentiation, and suppression of tumor-like growth in the Drosophila egg chamber
    Jiang Xu
    Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, United States of America
    PLoS ONE 6:e20180. 2011
    ....
  54. doi Rab11 is required for cell adhesion, maintenance of cell shape and actin-cytoskeleton organization during Drosophila wing development
    Tanmay Bhuin
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, India
    Int J Dev Biol 55:269-79. 2011
    ..Small monomeric Rab GTPases are key players involved in intracellular membrane transport. Rab11, a subfamily of the Ypt/Rab gene family of ubiquitously expressed GTPases, is associated with recycling endosomes, ..
  55. pmc Systematic discovery of Rab GTPases with synaptic functions in Drosophila
    Chih Chiang Chan
    Department of Physiology, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Curr Biol 21:1704-15. 2011
    ..Here, we present the first systematic characterization of neuronal expression, subcellular localization, and function of Rab GTPases in an organism with a brain...
  56. doi Mutations in Cog7 affect Golgi structure, meiotic cytokinesis and sperm development during Drosophila spermatogenesis
    Giorgio Belloni
    Istituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Biologia e Biotecnologie Università di Roma Sapienza, P le A Moro 5, 00185 Roma, Italy
    J Cell Sci 125:5441-52. 2012
    ..We show that the recruitment of the small GTPase Rab11 and the phosphatidylinositol transfer protein Giotto (Gio) to the cleavage site requires a functioning wild-type ..
  57. pmc Drosophila S2 cells secrete wingless on exosome-like vesicles but the wingless gradient forms independently of exosomes
    Karen Beckett
    Division of Developmental Biology, MRC National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK
    Traffic 14:82-96. 2013
    ..Using these exosome markers and a cell-based RNAi assay, we found that the small GTPase Rab11 contributes significantly to exosome production...
  58. pmc Crag is a GEF for Rab11 required for rhodopsin trafficking and maintenance of adult photoreceptor cells
    Bo Xiong
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Biol 10:e1001438. 2012
    ..Here, we show that Crag, a DENN protein, is a guanine nucleotide exchange factor for Rab11 that is required for the homeostasis of Rh1 upon light exposure...
  59. doi Activated Cdc42 kinase regulates Dock localization in male germ cells during Drosophila spermatogenesis
    Abbas M Abdallah
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907 2054, USA
    Dev Biol 378:141-53. 2013
    ..Moreover, Dock forms a complex with Ack, and the localization of Dock in male germ cells depends on its SH2 domain. Together, our results suggest that Ack-dependent tyrosine phosphorylation recruits Dock to promote sperm differentiation...
  60. ncbi Sec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivo
    Shuya Wu
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Struct Mol Biol 12:879-85. 2005
    ..This C-terminal domain was found to bind a subset of Rab GTPases, especially Rab11, in a GTP-dependent manner...
  61. pmc Rhomboid cleaves Star to regulate the levels of secreted Spitz
    Rachel Tsruya
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    EMBO J 26:1211-20. 2007
    ..Cleavage of Star restricts the amount of Spi that is trafficked, and may explain the exceptional dosage sensitivity of the Star locus in flies...
  62. ncbi Sequential pulses of apical epithelial secretion and endocytosis drive airway maturation in Drosophila
    Vasilios Tsarouhas
    Wenner Gren Institute, Stockholm University, Department of Developmental Biology, Svante Arrheniusväg 16, Arrheniuslab E3, S 10691 Stockholm, Sweden
    Dev Cell 13:214-25. 2007
    ..The coordination of luminal matrix secretion and endocytosis may be a general mechanism in tubular organ morphogenesis and maturation...
  63. doi The endocytic pathway acts downstream of Oskar in Drosophila germ plasm assembly
    Tsubasa Tanaka
    Laboratory for Germline Development, RIKEN Center for Developmental Biology, Kobe, Hyogo 650 0047, Japan
    Development 135:1107-17. 2008
    ..We propose that Osk stimulates endosomal cycling, which in turn promotes F-actin reorganization to anchor the pole plasm components to the oocyte cortex...
  64. ncbi Trafficking through Rab11 endosomes is required for cellularization during Drosophila embryogenesis
    Anne Pelissier
    Laboratoire de Genetique et de Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, France
    Curr Biol 13:1848-57. 2003
    ..In Drosophila, the process is specialized and called cellularization. The trafficking pathways that underlie this process and that are responsible for the mobilization of membrane pools, however, remain poorly understood...
  65. pmc Cdc42 and Par proteins stabilize dynamic adherens junctions in the Drosophila neuroectoderm through regulation of apical endocytosis
    Kathryn P Harris
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    J Cell Biol 183:1129-43. 2008
    ..This study reveals functional interactions between apical polarity proteins and endocytosis that are critical for stabilizing dynamic basolateral AJs...
  66. pmc A data-mining approach to rank candidate protein-binding partners-The case of biogenesis of lysosome-related organelles complex-1 (BLOC-1)
    I A Rodriguez-Fernandez
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    J Inherit Metab Dis 32:190-203. 2009
    ..Interestingly, genetic analyses in D. melanogaster uncovered a synthetic sick/lethal interaction between Rab11 and lightoid...
  67. doi JNK signalling influences intracellular trafficking during Drosophila morphogenesis through regulation of the novel target gene Rab30
    Chloe Thomas
    Institute of Developmental Biology and Cancer, University of Nice, UMR CNRS, France
    Dev Biol 331:250-60. 2009
    ..We propose that JNK activity upregulates genes involved in intracellular transport in order to provide an increased level of trafficking activity in cells undergoing complex morphogenetic arrangements such as dorsal closure...
  68. pmc Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt
    Akiko Mukai
    Research Group of Glycobiology and Glycotechnology, Mitsubishi Kagaku Institute of Life Sciences, Machida, Japan
    EMBO J 29:2114-25. 2010
    ..These results unveil a novel mechanism that regulates the cellular responsiveness to Wg/Wnt by controlling the cell surface level of Frizzled...
  69. doi A novel function for the Rab5 effector Rabenosyn-5 in planar cell polarity
    Giovanna Mottola
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Development 137:2353-64. 2010
    ..Our results suggest that establishment of planar polarity requires the activity of Rbsn-5 in regulating both the endocytic trafficking of Fmi at the apical cell boundaries and hair morphology...
  70. doi Lysosomal membrane protein composition, acidic pH and sterol content are regulated via a light-dependent pathway in metazoan cells
    M G Swetha
    National Centre for Biological Sciences, Bangalore, India
    Traffic 12:1037-55. 2011
    ..Depletion of the mammalian counterpart of Light, hVps41, in a human cell line also inhibits delivery of hLAMP to endosomes, suggesting an evolutionarily conserved pathway in metazoa...
  71. pmc The phosphoinositide-associated protein Rush hour regulates endosomal trafficking in Drosophila
    Ieva Gailite
    Stammzellbiologie, Abteilung Anatomie und Zellbiologie, Georg August Universitat Gottingen, 37077 Gottingen, Germany
    Mol Biol Cell 23:433-47. 2012
    ..These results indicate that Rush controls trafficking from early to late endosomes and from late endosomes to lysosomes by modulating the activity of Rab proteins...
  72. doi Deficient Notch signaling associated with neurogenic pecanex is compensated for by the unfolded protein response in Drosophila
    Tomoko Yamakawa
    Department of Biological Science and Technology, Tokyo University of Science, Noda, Chiba, 278 8510 Japan
    Development 139:558-67. 2012
    ..Our results indicate that the ER plays a previously unrecognized role in N signaling and that this ER function depends on pcx activity...
  73. doi Mutational analysis supports a core role for Drosophila α-catenin in adherens junction function
    Ritu Sarpal
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    J Cell Sci 125:233-45. 2012
    ..We also show that the α-Cat mutant phenotype can be rescued by the expression of a DE-cadherin::α-Catenin fusion protein, which argues against an essential cytosolic, cadherin-independent role of Drosophila α-Catenin...
  74. pmc Dusky-like functions as a Rab11 effector for the deposition of cuticle during Drosophila bristle development
    Ranganayaki Nagaraj
    Biology Department, Cell Biology Department, Institute for Morphogenesis and Regenerative Medicine, University of Virginia, Charlottesville, VA 22903, USA
    Development 139:906-16. 2012
    ..We show that the small GTPase Rab11 mediates the organized deposition of chitin, a major cuticle component in bristles, and disrupting Rab11 function ..
  75. pmc Rab11 rescues synaptic dysfunction and behavioural deficits in a Drosophila model of Huntington's disease
    Joern R Steinert
    MRC Toxicology Unit, University of Leicester, Hodgkin Building, Lancaster Road, Leicester, UK
    Hum Mol Genet 21:2912-22. 2012
    ..protein that underlies this disorder leads to perturbations in many cellular pathways, including the disruption of Rab11-dependent endosomal recycling...
  76. doi In-vivo evidence for the disruption of Rab11 vesicle transport by loss of huntingtin
    Derek Power
    Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, New York 14260, USA
    Neuroreport 23:970-7. 2012
    ..Surprisingly, we found that HTT influences Rab11 vesicles, not Rab5 vesicles. Reduction of HTT perturbed the transport of Rab11 vesicles...
  77. pmc Membrane traffic between genomes
    J Armstrong
    School of Biological Sciences, University of Sussex, Falmer, Brighton, BN19 QG, UK
    Genome Biol 1:REVIEWS104. 2000
    ..A comparison of these families from the budding yeast, fission yeast, nematode and fruitfly genomes has implications for the organization of membrane traffic in different organisms...
  78. ncbi Morphogen transport along epithelia, an integrated trafficking problem
    Jean Paul Vincent
    National Institute for Medical Research, The Ridgeway Mill Hill, NW7 1AA, London, United Kingdom
    Dev Cell 3:615-23. 2002
    ..The question of how this is achieved has aroused the interest of many cell biologically minded developmental biologists...
  79. ncbi Junctions and vesicular trafficking during Drosophila cellularization
    Thomas Lecuit
    Laboratoire de Genetique et de Physiologie du Developpement, UMR 6545 CNRS Université de la Méditerranée, Institut de Biologie du Developpement de Marseille, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    J Cell Sci 117:3427-33. 2004
    ..The novel proteins Nullo and Slam, which are specifically induced during cellularization, represent developmental regulators of membrane growth during cellularization...
  80. ncbi Mechanisms of morphogen movement
    Maura Strigini
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, United Kingdom
    J Neurobiol 64:324-33. 2005
    ....
  81. pmc Numb and alpha-Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs
    Andrea Hutterer
    Institute of Molecular Biotechnology, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    EMBO Rep 6:836-42. 2005
    ..Our results establish numb- and alpha-adaptin-dependent endocytosis of Sanpodo as the mechanism by which Notch is regulated during external sensory organ development...
  82. ncbi Recycling polarity
    W Gregory Somers
    Temasek Lifesciences Laboratory, The National University of Singapore
    Dev Cell 9:312-3. 2005
    ..Three current papers in Cell and in this issue of Developmental Cell highlight the role of the exocyst in recycling of membrane proteins from endosomes to the plasma membrane in asymmetric cell division and polarized epithelial cells...
  83. ncbi The endocytic control of JAK/STAT signalling in Drosophila
    Olivier Devergne
    Institute of Developmental Biology and Cancer, CNRS UMR 6543, University of Nice Sophia Antipolis, Parc Valrose 06108 Nice Cedex 2, France
    J Cell Sci 120:3457-64. 2007
    ..rab5, Hrs or deep orange led to an inhibition of the JAK/STAT pathway, whereas this pathway was unchanged when rab11 was affected. This suggests that internalization and trafficking are both required for JAK/STAT activity...
  84. ncbi Asymmetric localisation of Miranda and its cargo proteins during neuroblast division requires the anaphase-promoting complex/cyclosome
    Cathy Slack
    MRC Centre for Developmental Neurobiology, New Hunt s House, King s College London, Guy s Campus, London SE1 1UL, UK
    Development 134:3781-7. 2007
    ..Our results demonstrate that APC/C activity and ubiquitylation of Miranda are required for the asymmetric localisation of Miranda and its cargo proteins to the NB cortex...
  85. pmc New components of the Drosophila fusome suggest it plays novel roles in signaling and transport
    Daniel V Lighthouse
    Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution, Baltimore, MD 21218, USA
    Dev Biol 317:59-71. 2008
    ..In contrast, rab11 is required to maintain the germline stem cells, and to maintain the vesicle content of the spectrosome, ..
  86. doi Rab11 is essential for fertility in Drosophila
    Anand K Tiwari
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, Uttar Pradesh, India
    Cell Biol Int 32:1158-68. 2008
    b>Rab11, a small GTP binding protein involved in vesicular trafficking, has emerged as a key player in regulating various cellular events during Drosophila development and differentiation...
  87. pmc Regulation of early endosomal entry by the Drosophila tumor suppressors Rabenosyn and Vps45
    Holly A Morrison
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Mol Biol Cell 19:4167-76. 2008
    ..This work represents the first characterization of a Rab5 effector as a tumor suppressor, and it provides in vivo evidence for a Rbsn-Vps45 complex on early endosomes that links Rab5 to the SNARE fusion machinery...
  88. pmc Interactions between the juvenile Batten disease gene, CLN3, and the Notch and JNK signalling pathways
    Richard I Tuxworth
    MRC Centre for Developmental Neurobiology, New Hunt s House, Guy s Hospital Campus, King s College London, London, UK
    Hum Mol Genet 18:667-78. 2009
    ..We have identified previously unknown interactions between CLN3 and the Notch and Jun N-terminal kinase signalling pathways and have uncovered a potential role for the RNA splicing and localization machinery in regulating CLN3 function...
  89. pmc Regulation of Notch and Wingless signalling by phyllopod, a transcriptional target of the EGFR pathway
    Raghavendra Nagaraj
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    EMBO J 28:337-46. 2009
    ..Furthermore, this study identifies a Phyl-regulated class of endosomal vesicles that specifically include components of Notch and Wg signalling...
  90. pmc Analysis of endocytic pathways in Drosophila cells reveals a conserved role for GBF1 in internalization via GEECs
    Gagan D Gupta
    National Centre for Biological Sciences, Bangalore, India
    PLoS ONE 4:e6768. 2009
    ..Furthermore, GBF1 activation is required for the GEEC pathway even in the presence of Brefeldin A, implying that, like Arf1, it has a role in endocytosis that is separable from its role in secretion...
  91. pmc The cell adhesion molecules Echinoid and Friend of Echinoid coordinate cell adhesion and cell signaling to regulate the fidelity of ommatidial rotation in the Drosophila eye
    Jennifer L Fetting
    Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 136:3323-33. 2009
    ..Significantly, we demonstrate that at least one PCP protein, Stbm, is required in R7 to control the degree of ommatidial rotation...
  92. pmc TRAPPII is required for cleavage furrow ingression and localization of Rab11 in dividing male meiotic cells of Drosophila
    CARMEN C ROBINETT
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cell Sci 122:4526-34. 2009
    ..Localization of the membrane-trafficking GTPase Rab11 to the cleavage furrow requires wild-type function of bru, and genetic interactions between bru and Rab11 increase ..
  93. pmc Glycolipid trafficking in Drosophila undergoes pathway switching in response to aberrant cholesterol levels
    Ralf Hortsch
    Institute of Bioengineering and Nanotechnology, Agency for Science, Technology, and Research, Singapore
    Mol Biol Cell 21:778-90. 2010
    ....
  94. doi In vivo coupling of cell elongation and lumen formation in a single cell
    Louis Gervais
    Institut de Biologia Molecular de Barcelona CSIC, Baldiri Reixac 10 12, 08028 Barcelona, Spain
    Curr Biol 20:359-66. 2010
    ..Given the similarities in the formation of fine respiratory tubes and capillaries, we propose that an inward membrane growth model could account for lumen formation in both processes...
  95. doi A role of receptor Notch in ligand cis-inhibition in Drosophila
    Isabelle Becam
    Institute for Research in Biomedicine IRB Barcelona, Parc Cientific de Barcelona, Baldiri Reixac 10 12, 08028 Barcelona, Spain
    Curr Biol 20:554-60. 2010
    ....
  96. pmc Rab-mediated vesicular transport is required for neuronal positioning in the developing Drosophila visual system
    Tarek Houalla
    McGill Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health Centre, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada
    Mol Brain 3:19. 2010
    ..While the initial events of neuronal migration have been extensively studied, less is known about the molecular details underlying the establishment of neuronal architecture after initial migration...
  97. doi Rab11 regulates JNK and Raf/MAPK-ERK signalling pathways during Drosophila wing development
    Tanmay Bhuin
    Department of Zoology, Banaras Hindu University, Varanasi, India
    Cell Biol Int 34:1113-8. 2010
    ..In our earlier communication, we have shown that mutation in Rab11 (a subfamily of the Ypt/Rab gene family) results in the activation of JNK signalling pathways in Drosophila eye...
  98. pmc The functions of auxilin and Rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling
    Susan M L Banks
    Section of Molecular Cell and Developmental Biology and Institute for Cell and Molecular Biology, The University of Texas at Austin, Austin, Texas, United States of America
    PLoS ONE 6:e18259. 2011
    ..A key piece of evidence supporting the recycling model is the requirement in signaling cells for Rab11, which encodes a GTPase critical for endosomal recycling...
  99. doi Drosophila 14-3-3ε has a crucial role in anti-microbial peptide secretion and innate immunity
    Tetyana Shandala
    Division of Human Immunology, Centre for Cancer Biology, Adelaide SA5000, Australia
    J Cell Sci 124:2165-74. 2011
    ..Drosomycin appeared to be delivered towards the plasma membrane in Rab4- and Rab11-positive vesicles and smaller Rab11-positive vesicles...
  100. ncbi Rab proteins of Drosophila melanogaster: novel members of the Rab-protein family
    A K Satoh
    Department of Biology, Graduate School of Science, Osaka University, Japan
    FEBS Lett 404:65-9. 1997
    ..In addition, DRabRP4 has strong GTP-binding activity, when synthesized in E. coli cells. These results indicate that DRabRPs are novel members of the Rab-protein family. Molecular phylogenetic analysis also supported this conclusion...
  101. ncbi Molecular cloning and characterization of Drosophila genes encoding small GTPases of the rab and rho families
    T Sasamura
    Department of Physics, Graduate School of Science, University of Tokyo, Bunkyo ku, Japan
    Mol Gen Genet 254:486-94. 1997
    ..They can be classified into three rab family genes (Drab2, Drab5, Drab11) and five rho family genes (Drac1a, Drac1b, Drac3, Dcdc42, DrhoA)...