Pten

Summary

Gene Symbol: Pten
Description: Phosphatase and tensin homolog
Alias: CG5671, DPTEN, Dmel\CG5671, PTEN, PTEN3, dPTEN, dPten, dpten, pten, CG5671 gene product from transcript CG5671-RB, CG5671-PA, CG5671-PB, CG5671-PC, CG5671-PD, CG5671-PE, CG5671-PG, CG5671-PH, PI 3-phosphatase, PTEN, PtdIns(3,4,5)P3 phosphatase, Pten-PA, Pten-PB, Pten-PC, Pten-PD, Pten-PE, Pten-PG, Pten-PH, drosophila phosphatase and tensin homologue deleted on chromosome 10, phosphatase and tensin homolog, phosphatase and tensin homologue, phosphatidylinositol (3,4,5)-trisphosphate phosphatase
Species: fruit fly

Top Publications

  1. ncbi PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth
    Tianyan Gao
    Department of Pharmacology, University of California at San Diego, La Jolla, California 92093, USA
    Mol Cell 18:13-24. 2005
  2. doi The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway
    Carole L C Poon
    Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, 7 St Andrews Place, East Melbourne, Victoria 3002, Australia
    Dev Cell 21:896-906. 2011
  3. pmc Su(dx) E3 ubiquitin ligase-dependent and -independent functions of polychaetoid, the Drosophila ZO-1 homologue
    Alexandre Djiane
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, England, UK
    J Cell Biol 192:189-200. 2011
  4. ncbi Regulated and polarized PtdIns(3,4,5)P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells
    Noelia Pinal
    Medical Research Council Laboratory for Molecular Cell Biology and Cell Biology Unit, Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT London, United Kingdom
    Curr Biol 16:140-9. 2006
  5. ncbi PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development
    H Huang
    Howard Hughes Medical Institute and Department of Genetics, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, CT 06536 0812, USA
    Development 126:5365-72. 1999
  6. pmc Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway
    D C Goberdhan
    Research School of Biosciences, Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
    Genes Dev 13:3244-58. 1999
  7. ncbi Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways
    X Gao
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas, 75235 9040, USA
    Dev Biol 221:404-18. 2000
  8. pmc Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways
    J C Clemens
    Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109 0606, USA
    Proc Natl Acad Sci U S A 97:6499-503. 2000
  9. ncbi The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila
    S E Scanga
    Department of Medical Biophysics, Division of Cell and Molecular Biology, Ontario Cancer Institute, University Health Network, Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada, M5G 2M9
    Oncogene 19:3971-7. 2000
  10. pmc Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin
    S Oldham
    Zoologisches Institut, Universitat Zurich, 8057 Zurich, Switzerland
    Genes Dev 14:2689-94. 2000

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Scientific Experts

Detail Information

Publications105 found, 100 shown here

  1. ncbi PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth
    Tianyan Gao
    Department of Pharmacology, University of California at San Diego, La Jolla, California 92093, USA
    Mol Cell 18:13-24. 2005
    ..Reintroduction of PHLPP into a glioblastoma cell line causes a dramatic suppression of tumor growth. These data are consistent with PHLPP terminating Akt signaling by directly dephosphorylating and inactivating Akt...
  2. doi The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway
    Carole L C Poon
    Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, 7 St Andrews Place, East Melbourne, Victoria 3002, Australia
    Dev Cell 21:896-906. 2011
    ..Given that SWH pathway activity is subverted in many human cancers, our findings identify human TAO kinases as potential tumor suppressor genes...
  3. pmc Su(dx) E3 ubiquitin ligase-dependent and -independent functions of polychaetoid, the Drosophila ZO-1 homologue
    Alexandre Djiane
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, England, UK
    J Cell Biol 192:189-200. 2011
    ..As both Su(dx) and Expanded regulate trafficking, we propose that a conserved role of ZO proteins is to coordinate receptor trafficking and signaling with junctional organization...
  4. ncbi Regulated and polarized PtdIns(3,4,5)P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells
    Noelia Pinal
    Medical Research Council Laboratory for Molecular Cell Biology and Cell Biology Unit, Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT London, United Kingdom
    Curr Biol 16:140-9. 2006
    ..However, little is known about the mechanisms by which such apical factors might regulate the differentiation of the apical membrane into functional domains such as an apical-most stack of microvilli or more lateral sub-apical membrane...
  5. ncbi PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development
    H Huang
    Howard Hughes Medical Institute and Department of Genetics, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, CT 06536 0812, USA
    Development 126:5365-72. 1999
    Mutations in the tumor suppressor gene PTEN (MMAC1/TEP1) are associated with a large number of human cancers and several autosomal-dominant disorders...
  6. pmc Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway
    D C Goberdhan
    Research School of Biosciences, Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
    Genes Dev 13:3244-58. 1999
    ..Here we show that the highly evolutionarily conserved Drosophila PTEN homolog, DPTEN, suppresses hyperplastic growth in flies by reducing cell size and number...
  7. ncbi Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways
    X Gao
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas, 75235 9040, USA
    Dev Biol 221:404-18. 2000
    ..Here, we show that dPTEN, a Drosophila homolog of the mammalian PTEN tumor suppressor gene, plays an essential role in the control of cell ..
  8. pmc Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways
    J C Clemens
    Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109 0606, USA
    Proc Natl Acad Sci U S A 97:6499-503. 2000
    ..Finally, we demonstrate that blocking the expression of Drosophila PTEN results in the activation of DAKT...
  9. ncbi The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila
    S E Scanga
    Department of Medical Biophysics, Division of Cell and Molecular Biology, Ontario Cancer Institute, University Health Network, Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada, M5G 2M9
    Oncogene 19:3971-7. 2000
    ..by phosphatidylinositol 3-OH kinase (PI3'K) signaling and has shown to be hyperactivated through the loss of the PTEN tumor suppressor...
  10. pmc Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin
    S Oldham
    Zoologisches Institut, Universitat Zurich, 8057 Zurich, Switzerland
    Genes Dev 14:2689-94. 2000
    ..These results are consistent with dTOR residing on a parallel amino acid sensing pathway...
  11. pmc Regulation of cellular growth by the Drosophila target of rapamycin dTOR
    H Zhang
    Chiron Corporation, Emeryville, California 94608, USA
    Genes Dev 14:2712-24. 2000
    ..Our results suggest that dTOR regulates growth during animal development by coupling growth factor signaling to nutrient availability...
  12. pmc Genetic control of size in Drosophila
    S Oldham
    Zoological Institute, University of Zurich, Switzerland
    Philos Trans R Soc Lond B Biol Sci 355:945-52. 2000
    ..In this article we will review recent evidence from vertebrates and particularly from Drosophila that implicates insulin/insulin-like growth factor-I and other growth pathways in the control of cell, organ and body size...
  13. ncbi Regulation of translation initiation by FRAP/mTOR
    A C Gingras
    Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    Genes Dev 15:807-26. 2001
  14. ncbi The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation
    N Tapon
    Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
    Cell 105:345-55. 2001
    ..In postmitotic mutant cells, levels of Cyclin E and Cyclin A are elevated. This correlates with a tendency for these cells to reenter the cell cycle inappropriately as is observed in the human lesions...
  15. ncbi Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size
    C J Potter
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, CT 06536, USA
    Cell 105:357-68. 2001
    ..Genetic epistasis data are consistent with a model that Tsc1 and Tsc2 function together in the insulin signaling pathway...
  16. pmc TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth
    X Gao
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9040, USA
    Genes Dev 15:1383-92. 2001
    ..Taken together, our studies identified the TSC tumor suppressors as novel negative regulators of insulin signaling...
  17. pmc PDK1 regulates growth through Akt and S6K in Drosophila
    F Rintelen
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 98:15020-5. 2001
    ..Thus, the results suggest that dPDK1 is required for dRSK but not dPKN activation and that it regulates insulin-mediated growth through two main effector branches, dAkt and dS6K...
  18. ncbi Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions
    Jessica S Britton
    Molecular and Cellular Biology Program, Seattle, WA 98109, USA
    Dev Cell 2:239-49. 2002
    ..Hence we surmise that an essential function of insulin/PI3K signaling in Drosophila is to coordinate cellular metabolism with nutritional conditions...
  19. ncbi Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB
    Hugo Stocker
    Zoologisches Institut der Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Science 295:2088-91. 2002
    The phosphoinositide phosphatase PTEN is mutated in many human cancers...
  20. ncbi The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels
    Sean Oldham
    Universitat Zurich, Zoologisches Institut, Winterthurerstrasse 190, CH 8057, Switzerland
    Development 129:4103-9. 2002
    ..Furthermore, we present biochemical and genetic evidence that loss of the homolog of the tumor suppressor gene, Pten, results in increased PtdInsP(3) levels and that these increased levels are sufficient to compensate for the ..
  21. ncbi Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
    Xinsheng Gao
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9040, USA
    Nat Cell Biol 4:699-704. 2002
    ..Our studies identify Tsc1 and Tsc2 as regulators of the amino acid-TOR pathway and provide a new paradigm for how proteins involved in nutrient sensing function as tumour suppressors...
  22. pmc Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing
    David A Prober
    Molecular and Cellular Biology Program, University of Washington, Seattle, Washington 98195, USA
    Genes Dev 16:2286-99. 2002
    ....
  23. pmc Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling
    Thomas Radimerski
    Friedrich Miescher Institute for Biomedical Research, CH 4058, Basel, Switzerland
    Genes Dev 16:2627-32. 2002
    ..In contrast, the dPTEN tumor suppressor, a negative effector of PI3K, has little effect on dS6K, but negatively regulates dPKB...
  24. ncbi Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control
    Sean Oldham
    The Burnham Institute, La Jolla, CA 92037, USA
    Trends Cell Biol 13:79-85. 2003
    ..This review summarizes current studies primarily from Drosophila regarding the function of the insulin/IGF system in the control of growth...
  25. ncbi Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
    Hugo Stocker
    Zoologisches Institut der Universitat Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Nat Cell Biol 5:559-65. 2003
    ....
  26. ncbi Rheb promotes cell growth as a component of the insulin/TOR signalling network
    Leslie J Saucedo
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Nat Cell Biol 5:566-71. 2003
    ..Levels of rheb mRNA are rapidly induced in response to protein starvation, and overexpressed Rheb can drive cell growth in starved animals, suggesting a role for Rheb in the nutritional control of cell growth...
  27. pmc A new genetic locus controlling growth and proliferation in Drosophila melanogaster
    Sophie Raisin
    Institute for Signaling, Developmental Biology and Cancer Research, UMR6543 CNRS, Parc Valrose, 06108 Nice Cedex 2, France
    Genetics 164:1015-25. 2003
    ..This suggested either that a particular combination of these transcripts was necessary or that other sequences are involved...
  28. pmc The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling
    Martin A Jünger
    Zoologisches Institut, Universitat Zurich, Winterthurerstr, 190, CH 8057 Zurich, Switzerland
    J Biol 2:20. 2003
    ..In this study, we present a genetic characterization of dFOXO, the only Drosophila FOXO ortholog...
  29. ncbi A nutrient sensor mechanism controls Drosophila growth
    Julien Colombani
    Institute for Signaling, Developmental Biology and Cancer Research, UMR6543 CNRS Parc Valrose, 06108, Cedex 2, Nice, France
    Cell 114:739-49. 2003
    ..Our results demonstrate that the fat body functions as a nutrient sensor that restricts global growth through a humoral mechanism...
  30. ncbi Suppression of a phosphatidylinositol 3-kinase signal by a specific spliced variant of Drosophila PTEN
    Tomohiko Maehama
    Department of Pharmacology, Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Tokyo 113 8613, Japan
    FEBS Lett 565:43-7. 2004
    Drosophila PTEN (dPTEN) plays indispensable roles in the development of Drosophila melanogaster by controlling cell size and number...
  31. ncbi Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
    Dae Sung Hwangbo
    Division of Biology and Medicine, Box G W, Brown University, Providence, Rhode Island 02912, USA
    Nature 429:562-6. 2004
    ..These findings suggest that autonomous and non-autonomous roles of insulin signalling combine to control ageing...
  32. ncbi Role and regulation of starvation-induced autophagy in the Drosophila fat body
    Ryan C Scott
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis 55455 USA
    Dev Cell 7:167-78. 2004
    ..Thus, in cells lacking TOR, autophagy plays a protective role that is dominant over its potential role as a growth suppressor...
  33. ncbi Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway
    Tor Erik Rusten
    Department of Biochemistry, The Norwegian Radium Hospital, Montebello, N 0310 Oslo
    Dev Cell 7:179-92. 2004
    ..Hence, these studies link hormonal induction of autophagy to the regulatory function of the PI3K signaling pathway in vivo...
  34. ncbi Drosophila PI3 kinase and Akt involved in insulin-stimulated proliferation and ERK pathway activation in Schneider cells
    Sung Eun Kim
    Department of Biotechnology, Division of Cellular and Molecular Biology, Yonsei University, 132 Shinchon Dong, Seodemun Gu, Seoul 120 752, South Korea
    Cell Signal 16:1309-17. 2004
    ..The insulin-induced activations of dERK and dAKT were blocked by LY294002, dPTEN, and by an AKT inhibitor, indicating involvement of dPI3K and dAKT in the insulin-induced dERK and dAKT ..
  35. ncbi Temporal control of differentiation by the insulin receptor/tor pathway in Drosophila
    Joseph M Bateman
    Cancer Research UK, 44 Lincoln s Inn Fields, London, WC2A 3PX, England
    Cell 119:87-96. 2004
    ..Examination of InR, PI3K, PTEN, Tor, Rheb, and S6 kinase mutants demonstrates that increased InR signaling leads to precocious differentiation ..
  36. pmc The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila
    Jan H Reiling
    Zoologisches Institut, Universitat Zurich, CH 8057 Zurich, Switzerland
    Genes Dev 18:2879-92. 2004
    ....
  37. ncbi Insulin regulation of heart function in aging fruit flies
    Robert J Wessells
    The Burnham Institute, Center for Neuroscience and Aging, 10901 Torrey Pines Road, La Jolla, California 92037, USA
    Nat Genet 36:1275-81. 2004
    ..Moreover, interfering with InR signaling exclusively in the heart, by overexpressing the phosphatase dPTEN or the forkhead transcription factor dFOXO, prevents the decline in cardiac performance with age...
  38. ncbi Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    D D Sarbassov
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 307:1098-101. 2005
    ..Rictor-mTOR may serve as a drug target in tumors that have lost the expression of PTEN, a tumor suppressor that opposes Akt/PKB activation.
  39. ncbi Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling
    Walter von Stein
    Abteilung Stammzellbiologie, CMPB, Georg August Universitat Gottingen, Justus von Liebig Weg 11, 37077 Gottingen, Germany
    Development 132:1675-86. 2005
    ..How the complex exerts these different functions is not known. We show that the lipid phosphatase PTEN directly binds to Baz in vitro and in vivo, and colocalizes with Baz in the apical cortex of epithelia and ..
  40. ncbi Susi, a negative regulator of Drosophila PI3-kinase
    Franz Wittwer
    Zoologisches Institut, Universitat Zurich, Winterthurerstr 190, CH 8057 Zurich, Switzerland
    Dev Cell 8:817-27. 2005
    ..The fact that Susi is expressed in a circadian rhythm, with highest levels during the night, suggests that Susi attenuates insulin signaling during the fasting period...
  41. pmc Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling
    Yufeng Yang
    Department of Pathology, Stanford University School of Medicine, and Geriatric Research, Education and Clinical Center Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 102:13670-5. 2005
    ..Manipulation of PI3K/Akt signaling may therefore offer therapeutic benefits for the treatment of PD...
  42. ncbi The role of the prothoracic gland in determining critical weight for metamorphosis in Drosophila melanogaster
    Christen Mirth
    Department of Biology, Box 351800, University of Washington, Seattle, Washington 98195, USA
    Curr Biol 15:1796-807. 2005
    ..We present evidence that in Drosophila, a component of the ring gland, the prothoracic gland (PG), assesses growth to determine when critical weight has been achieved...
  43. ncbi Body-size regulation: combining genetics and physiology
    Alexander W Shingleton
    Guyot Hall, Princeton University, Princeton, New Jersey 08544, USA
    Curr Biol 15:R825-7. 2005
    ..New research has revealed that the activity of the insulin-signaling pathway in the prothoracic gland of Drosophila modulates ecdysone release and thereby influences both the duration and rate of larval growth...
  44. ncbi Specialized hepatocyte-like cells regulate Drosophila lipid metabolism
    Eugenio Gutierrez
    Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 445:275-80. 2007
    ..These findings provide evidence that some lipid-processing functions of the mammalian liver are performed in insects by oenocytes...
  45. ncbi Multiple protein phosphatases are required for mitosis in Drosophila
    Feng Chen
    Cancer Research United Kingdom, Cell Cycle Genetics Research Group, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom
    Curr Biol 17:293-303. 2007
    ..Approximately one-third of the Drosophila kinome has been ascribed some cell-cycle function. However, little is known about which of its 117 protein phosphatases (PPs) or subunits have counteracting roles...
  46. pmc Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth
    Ville Hietakangas
    European Molecular Biology Laboratory Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Genes Dev 21:632-7. 2007
    ..loss of TORC2 activity strongly inhibited hyperplasia caused by elevated pathway activity, as in mutants of the tumor suppressor PTEN. Thus, TORC2 acts as a rheostat to broaden the range of AKT signaling at the high end of its range.
  47. pmc Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila
    Dayna J Hall
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    BMC Biol 5:10. 2007
    ..TOR activity is regulated by nutritional cues, suggesting that Rheb might either control, or respond to, nutrient availability...
  48. pmc Mechanisms of TSC-mediated control of synapse assembly and axon guidance
    Sarah Knox
    The Developmental Biology Center, Department of Pediatrics, The University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 2:e375. 2007
    ....
  49. pmc Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance
    Basil Honegger
    Zoological Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Biol 7:10. 2008
    ..In mammals, insulin-like growth factor binding proteins (IGFBPs) bind IGFs with high affinity and modulate their mitogenic, anti-apoptotic and metabolic actions, but no functional homologs have been identified in invertebrates so far...
  50. pmc Regulation of TORC1 by Rag GTPases in nutrient response
    Eunjung Kim
    Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093 081, USA
    Nat Cell Biol 10:935-45. 2008
    ..Genetic studies in Drosophila also show that Rag GTPases regulate cell growth, autophagy and animal viability during starvation. Our studies establish a function of Rag GTPases in TORC1 activation in response to amino acid signals...
  51. doi Persistent competition among stem cells and their daughters in the Drosophila ovary germline niche
    Christa Rhiner
    Spanish National Cancer Centre, E 28029 Madrid, Spain
    Development 136:995-1006. 2009
    ..Moreover, competitive interactions among stem cells may be relevant for the successful application of stem cell therapies in humans...
  52. pmc Natural genetic variation in transcriptome reflects network structure inferred with major effect mutations: insulin/TOR and associated phenotypes in Drosophila melanogaster
    Sergey V Nuzhdin
    Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA
    BMC Genomics 10:124. 2009
    ..We focus on the latter problem by describing genetic variation in transcript levels of genes in the InR/TOR pathway among 72 Drosophila melanogaster genotypes...
  53. pmc The ecdysone receptor controls the post-critical weight switch to nutrition-independent differentiation in Drosophila wing imaginal discs
    Christen K Mirth
    Department of Biology, Box 351800, University of Washington, Seattle, WA 98195, USA
    Development 136:2345-53. 2009
    ..These results suggest that post-critical weight, EcR signaling switches wing discs to a nutrition-independent mode of development via derepression...
  54. pmc The Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathway
    Christian Werz
    Institute of Molecular Systems Biology, Zurich, Switzerland
    PLoS Genet 5:e1000596. 2009
    ..Furthermore, chico; lnk double mutants are synthetically lethal, suggesting that Chico and Lnk fulfill independent but partially redundant functions in the activation of PI3K upon InR stimulation...
  55. doi Remote control of insulin secretion by fat cells in Drosophila
    Charles Geminard
    Institute for Developmental Biology and Cancer, CNRS University of Nice Sophia Antipolis, Parc Valrose, 06108 Nice, France
    Cell Metab 10:199-207. 2009
    ..Thus, the availability of nutrients is remotely sensed in fat body cells and conveyed to the brain IPCs by a humoral signal controlling ILP release...
  56. doi Insulin-degrading enzyme antagonizes insulin-dependent tissue growth and Abeta-induced neurotoxicity in Drosophila
    Manabu Tsuda
    Department of Biological Sciences, Tokyo Metropolitan University, Tokyo, Japan
    FEBS Lett 584:2916-20. 2010
    ..Using dIde(KO) as a model, further investigations into the biological functions of IDE and its role in the pathogenesis of DM2 and AD can be made...
  57. doi Drosophila SPARC is a self-protective signal expressed by loser cells during cell competition
    Marta Portela
    Molecular Oncology Programme, Spanish National Cancer Centre CNIO, Melchor Fernandez Almagro, 3, Madrid 28029, Spain
    Dev Cell 19:562-73. 2010
    ..Overall, we describe the unexpected existence of a physiological mechanism that counteracts cell competition during development...
  58. doi Anaplastic lymphoma kinase spares organ growth during nutrient restriction in Drosophila
    Louise Y Cheng
    Division of Developmental Neurobiology, Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
    Cell 146:435-47. 2011
    ..Together, these findings identify a brain-sparing mechanism that shares some regulatory features with the starvation-resistant growth programs of mammalian tumors...
  59. pmc Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo
    Federica Parisi
    Department of Biology, City College of City University of New York, New York, USA
    BMC Biol 9:65. 2011
    ..Using biochemical and genetic approaches we tried to identify novel mechanisms that control Myc activity upon activation of insulin and TOR signaling pathways...
  60. pmc FOXO regulates organ-specific phenotypic plasticity in Drosophila
    Hui Yuan Tang
    Department of Zoology, Michigan State University, East Lansing, Michigan, United States of America
    PLoS Genet 7:e1002373. 2011
    ..These data indicate that the extent of phenotypic plasticity may be modified by changes in the expression of genes involved in signaling environmental information to developmental processes...
  61. pmc FijiWings: an open source toolkit for semiautomated morphometric analysis of insect wings
    Alexander C Dobens
    Division of Molecular Biology and Biochemistry, School of Biological Sciences, University of Missouri Kansas City, Kansas City, Missouri 64110, USA
    G3 (Bethesda) 3:1443-9. 2013
    ..FijiWings is freely available and will be of interest to a broad community of fly geneticists studying both the effect of gene function on wing patterning and the evolution of wing morphology. ..
  62. pmc Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B
    Jose M Lizcano
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 374:297-306. 2003
    ..to decrease expression of dPI3K and the PtdIns(3,4,5) P (3) phosphatase dPTEN ( Drosophila phosphatase and tensin homologue deleted on chromosome 10) in Kc167 and S2 cells...
  63. pmc Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster
    Mathieu Miron
    Department of Biochemistry and McGill Cancer Center, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
    Mol Cell Biol 23:9117-26. 2003
    ..Surprisingly, RNAi of dAkt also affected insulin-stimulated phosphorylation of dS6K, indicating that dAkt may also play a role in dS6K phosphorylation...
  64. ncbi DJ-1, a novel regulator of the tumor suppressor PTEN
    Raymond H Kim
    Advanced Medical Discovery Institute, The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Canada M5G 2C1
    Cancer Cell 7:263-73. 2005
    The phosphatidylinositol 3' kinase (PI3'K) pathway, which regulates cell survival, is antagonized by the PTEN tumor suppressor. The regulation of PTEN is unclear...
  65. pmc Autophagy is an essential component of Drosophila immunity against vesicular stomatitis virus
    Spencer Shelly
    Department of Microbiology, Penn Genome Frontiers Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Immunity 30:588-98. 2009
    ..Altogether, these data uncover an intrinsic antiviral program that links viral recognition to the evolutionarily conserved nutrient-signaling and autophagy pathways...
  66. pmc SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
    Thomas Porstmann
    Gene Expression Analysis Laboratory, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Cell Metab 8:224-36. 2008
    ..Our results suggest that the PI3K/Akt/TOR pathway regulates protein and lipid biosynthesis in an orchestrated manner and that both processes are required for cell growth...
  67. pmc FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging
    Fabio Demontis
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 143:813-25. 2010
    ..These findings reveal an organism-wide regulation of proteostasis in response to muscle aging and a key role of FOXO/4E-BP signaling in the coordination of organismal and tissue aging...
  68. pmc A dp53-dependent mechanism involved in coordinating tissue growth in Drosophila
    Duarte Mesquita
    Institute for Research in Biomedicine, Barcelona, Spain
    PLoS Biol 8:e1000566. 2010
    ....
  69. pmc Molecular networks linked by Moesin drive remodeling of the cell cortex during mitosis
    Chantal Roubinet
    Cell Biology of Mitosis laboratory, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Cell Biol 195:99-112. 2011
    ..This fine balance of Moesin activity is further adjusted by Skittles and Pten, two enzymes that locally produce phosphoinositol 4,5-bisphosphate and thereby, regulate Moesin cortical ..
  70. doi Live-cell delamination counterbalances epithelial growth to limit tissue overcrowding
    Eliana Marinari
    Medical Research Council Laboratory of Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nature 484:542-5. 2012
    ..Because live-cell delamination constitutes a mechanistic link between epithelial hyperplasia and cell invasion, this is likely to have important implications for our understanding of the early stages of cancer development...
  71. ncbi Genetic control of cell size
    H Stocker
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Curr Opin Genet Dev 10:529-35. 2000
    ..Evidence is emerging for a signalling cascade conserved in evolution that links external nutrient sources to cell size...
  72. ncbi Lilliputian: an AF4/FMR2-related protein that controls cell identity and cell growth
    F Wittwer
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Development 128:791-800. 2001
    ..causes an autonomous reduction in cell size and partially suppresses the increased growth associated with loss of PTEN function...
  73. ncbi Regulation of Drosophila tracheal system development by protein kinase B
    J Jin
    Division of Cellular and Molecular Biology, Ontario Cancer Institute, University Health Network, Princess Margaret Hospital, Toronto, Ontario, M5G 2M9, Canada
    Dev Cell 1:817-27. 2001
    ..Using a combination of biochemical and transgenic approaches, we show that direct phosphorylation of Trh by PKB at serine 665 is essential for nuclear localization and functional activation of this regulator of branching morphogenesis...
  74. ncbi A Drosophila melanogaster cell line (S2) facilitates post-genome functional analysis of receptors and ion channels
    Paula R Towers
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, UK
    Bioessays 24:1066-73. 2002
    ..In addition, many useful orthologues of human disease genes are emerging from the Drosophila genome and the study of their functions and interactions is another area for postgenome applications of S2 cell lines...
  75. ncbi The tuberous sclerosis complex (TSC) pathway and mechanism of size control
    C J Potter
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA
    Biochem Soc Trans 31:584-6. 2003
    ..of growth-constraint genes using mosaic genetic screens in Drosophila melanogaster, including PTEN (phosphatase and tensin homologue deleted on chromosome 10), and the tuberous sclerosis complex (TSC) genes, Tsc1 and Tsc2...
  76. ncbi Light adaptation through phosphoinositide-regulated translocation of Drosophila visual arrestin
    Seung Jae Lee
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 39:121-32. 2003
    ..Since phospholipase C activity is required for activation of Drosophila phototransduction, these data point to a dual role of PIs in phototransduction...
  77. ncbi Phototransduction: shedding light on translocation
    Roger C Hardie
    Cambridge University Department of Anatomy, Downing Street, Cambridge CB2 3DY, UK
    Curr Biol 13:R775-7. 2003
    ..New work has identified a phosphoinositide lipid binding domain in Drosophila arrestin and implicates PIP(3) in control of arrestin translocation...
  78. pmc dAkt kinase controls follicle cell size during Drosophila oogenesis
    Valeria Cavaliere
    Dipartimento di Biologia Evoluzionistica Sperimentale, Bologna, Italy
    Dev Dyn 232:845-54. 2005
    ..Accordingly, expression of the antagonist dPTEN in the same follicular domains causes reduced follicle cell size...
  79. ncbi The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors
    Tamara Mikeladze-Dvali
    Department of Biology, Center for Developmental Genetics, New York University, New York, New York 10003, USA
    Cell 122:775-87. 2005
    ..This represents an unexpected postmitotic role for genes controlling cell proliferation (warts and its partner hippo and salvador) and cell growth (melted)...
  80. ncbi Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells
    Joerg Betschinger
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Cell 124:1241-53. 2006
    ..Similar defects are seen in lethal giant larvae (lgl) mutants where Brat and Prospero are not asymmetric. We have identified a molecular mechanism that may control self-renewal and prevent tumor formation in other stem cells as well...
  81. ncbi Cell biology: polarity bites
    Richard Fehon
    Nature 442:519-20. 2006
  82. pmc Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
    Qian Yang
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genes Dev 20:2820-32. 2006
    ..These data demonstrate that Sin1 together with Rictor are key components of mTORC2 and play an essential role in Akt phosphorylation and signaling...
  83. pmc Regulation of the activity of the tumor suppressor PTEN by thioredoxin in Drosophila melanogaster
    Zuohe Song
    Arizona Cancer Center, University of Arizona, 1515 N Campbell Blvd, Tucson, AZ 85724, USA
    Exp Cell Res 313:1161-71. 2007
    ..Recently, we have demonstrated that hTrx-1 binds to the C2 domain of the human tumor suppressor, PTEN, in a redox dependent manner...
  84. pmc Alteration of Drosophila life span using conditional, tissue-specific expression of transgenes triggered by doxycyline or RU486/Mifepristone
    Daniel Ford
    Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, 1050 Childs Way, Room 201, Los Angeles, CA 90089 2910, USA
    Exp Gerontol 42:483-97. 2007
    ..In contrast, motor-neuron-specific over-expression of MnSOD had no detectable effect on life span. The results suggest that motor-neuron tissue is not the essential tissue for either MnSOD induced longevity or toxicity in adult males...
  85. pmc Regulation of neurogenesis and epidermal growth factor receptor signaling by the insulin receptor/target of rapamycin pathway in Drosophila
    Helen McNeill
    The Wolfson Centre for Age Related Diseases, King s College, London SE1 1UL, United Kingdom
    Genetics 179:843-53. 2008
    ..Together these data suggest that InR/TOR signaling regulates the timing of differentiation through modulation of EGFR target genes in developing photoreceptors...
  86. doi The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila
    Natalia Vereshchagina
    Department of Physiology, Anatomy and Genetics, University of Oxford, Le Gros Clark Building, South Parks Road, Oxford OX1 3QX, UK
    J Cell Sci 121:3383-92. 2008
    Inappropriate regulation of the PI3-kinase/PTEN/Akt kinase-signalling cassette, a key downstream target of insulin/insulin-like growth factor signalling (IIS), is associated with several major human diseases such as diabetes, obesity and ..
  87. doi Notch signalling coordinates tissue growth and wing fate specification in Drosophila
    Neus Rafel
    ICREA and Institute for Research in Biomedicine IRB Científic de Barcelona, Baldiri Reixac 10, 08028 Barcelona, Spain
    Development 135:3995-4001. 2008
    ..These results highlight a crucial role of Notch in linking proliferation and fate specification in the developing wing primordium...
  88. pmc Dynamic control of cell cycle and growth coupling by ecdysone, EGFR, and PI3K signaling in Drosophila histoblasts
    Nikolay Ninov
    Instituto de Biologia Molecular de Barcelona, Consejo Superior de Investigaciones Cientificas, Barcelona, Spain
    PLoS Biol 7:e1000079. 2009
    ..It sets the stage for the comprehensive understanding of the coordination of cell growth and cell-cycle progression in complex multicellular eukaryotes...
  89. pmc A critical step for postsynaptic F-actin organization: regulation of Baz/Par-3 localization by aPKC and PTEN
    Preethi Ramachandran
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Dev Neurobiol 69:583-602. 2009
    ..the retention of Baz at this site depends on its dephosphorylation mediated by the lipid and protein phosphatase PTEN. Misregulation of the phosphorylation state of Baz by genetic alterations in PTEN or aPKC activity has detrimental ..
  90. pmc AKT and TOR signaling set the pace of the circadian pacemaker
    Xiangzhong Zheng
    Department of Neuroscience, Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Curr Biol 20:1203-8. 2010
    ....
  91. ncbi The genetic control of organ growth: insights from Drosophila
    D Weinkove
    Department of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, 1066 CX, The Netherlands
    Curr Opin Genet Dev 10:75-80. 2000
    ..Furthermore, the role of Drosophila homologues to human tumour suppressor genes and oncogenes in imaginal disc growth has been investigated...
  92. ncbi Mechanisms of size control
    C J Potter
    Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, Connecticut 06536 0812, USA
    Curr Opin Genet Dev 11:279-86. 2001
    ..The mechanisms of organ size control could also be critical targets for evolutionary events or disease processes such as tumorigenesis...
  93. ncbi Trachealess--a new transcription factor target for PKB/Akt
    J Downward
    Signal Transduction Laboratory, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Dev Cell 1:726-8. 2001
    ..Applying a combined genetic and biochemical approach has led to the identification of a new protein kinase B/Akt target, the transcription factor Trachealess...
  94. ncbi Insulin receptor-mediated organ overgrowth in Drosophila is not restricted by body size
    Deborah C I Goberdhan
    Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK
    Dev Genes Evol 212:196-202. 2002
    ..To test this in Drosophila, we induced excess Inr-dependent growth by removal of the Inr signalling antagonist, DPTEN, in the eyes of flies with dramatically different body sizes...
  95. ncbi Growth signaling: TSC takes its place
    Steven J Marygold
    Growth Regulation Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, WC2A 3PX, London, UK
    Curr Biol 12:R785-7. 2002
    ..Several new studies suggest that TSC1-TSC2 does this by inhibiting TOR and S6 kinase, and that PI 3-kinase-Akt signaling relieves this inhibition...
  96. ncbi The Drosophila bZIP transcription factor Vrille is involved in hair and cell growth
    Sébastien Szuplewski
    Laboratoire de Génétique du Développement et Evolution, Institut Jacques Monod, 2 Place Jussieu Tour 43, 75251 Paris Cedex 05, France
    Development 130:3651-62. 2003
    ..The phenotypes observed are consistent with the hypothesis that vri is required for normal cell growth and proliferation via the regulation of the actin cytoskeleton...
  97. pmc Localization of Tec29 to ring canals is mediated by Src64 and PtdIns(3,4,5)P3-dependent mechanisms
    Ning Lu
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    EMBO J 23:1089-100. 2004
    ..In the presence of Src64, it enhances membrane targeting of Tec29 by a PI(3,4,5)P(3)-mediated mechanism. In the absence of its PH domain, Tec29 constitutively localizes to ring canals, but still requires Src64 for full activation...
  98. ncbi Tuberous sclerosis complex: from Drosophila to human disease
    Duojia Pan
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9040, USA
    Trends Cell Biol 14:78-85. 2004
    ..Here, we review these exciting developments with an emphasis on Drosophila studies and discuss how Drosophila can be a powerful model system for an understanding of the molecular mechanisms of the activity of human disease genes...
  99. ncbi Neuronal differentiation: TOR and insulin receptor pathways set the tempo
    Pierre Leopold
    Institute for Signaling, Developmental Biology and Cancer Centre National de la Recherche Scientifique Parc Valrose, 06108 Nice Cedex 2, France
    Cell 119:4-5. 2004
    ..A recent study reveals a novel role for these pathways in controlling the timing of neuronal differentiation during Drosophila development, thus allowing a tight coordination between growth and differentiation programs...
  100. ncbi Expression of a secreted form of Dally, a Drosophila glypican, induces overgrowth phenotype by affecting action range of Hedgehog
    Satomi Takeo
    Department of Biology, Tokyo Metropolitan University, Hachioji shi, Tokyo 192 0397, Japan
    Dev Biol 284:204-18. 2005
    ..These findings support the recently proposed model that secreted glypicans have opposing and/or distinct effects on morphogen signaling from the membrane-tethered forms...
  101. pmc The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis
    Koichi Hamada
    Department of Molecular Biology, Department of Microbiology, Department of Gastroenterology, Akita University School of Medicine, Akita 010 8543, Japan
    Genes Dev 19:2054-65. 2005
    b>PTEN is an important tumor suppressor gene. Hereditary mutation of PTEN causes tumor-susceptibility diseases such as Cowden disease...

Research Grants4

  1. Cell Cycle and Development
    BRUCE EDGAR; Fiscal Year: 2004
    ....
  2. QUANTITATIVE TRAIT LOCI RELATED TO DROSOPHILA SPECIATION
    Sergey Nuzhdin; Fiscal Year: 2004
    ..This comprehensive assessment of the genetics of several traits will further our understanding of the genetics of speciation. ..
  3. Growth-regulatory targets of Drosophila Cyclin D/Cdk4
    BRUCE EDGAR; Fiscal Year: 2007
    ..Some of the identified genes could be useful targets for cancer diagnosis or anti-cancer chemotherapeutics. [unreadable] [unreadable]..
  4. Nucleotide polymorphisms responsible for expression variation in Drosophila
    Sergey Nuzhdin; Fiscal Year: 2009
    ..These studies will contribute to building a pathway-minded description of complex character variation. They will shed light on the genetic architecture of transcript level variation in nature. ..