pros

Summary

Gene Symbol: pros
Description: prospero
Alias: 0244/09, 0320/10, 0441/16, 0451/09, 0563/18, 0585/13, 0664/07, 0671/02, 0763/13, 0989/01, 1135/07, 1135/09, 1167/13, 1316/02, 671/2, BcDNA:HL08040, CG17228, DMPROSPER, DROPROSA, Dmel\CG17228, PROS, PROS-1, PROS-2, Pro, Pros, Prosp, Voila, anon-WO0140519.15, l(3)10419, l(3)j12C8, l(3)j6E2, l(3)rH013, l(3)rI160, l(3)rJ806, l(3)rK137, l(3)rK204, l(3)rL433, l(3)rO534, pro, voila, CG17228 gene product from transcript CG17228-RI, CG17228-PH, CG17228-PI, CG17228-PJ, CG17228-PK, CG17228-PL, CG17228-PM, a la voile et a la vapeur, pros-PH, pros-PI, pros-PJ, pros-PK, pros-PL, pros-PM
Species: fruit fly

Top Publications

  1. ncbi Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells
    Joerg Betschinger
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Cell 124:1241-53. 2006
  2. ncbi Role of inscuteable in orienting asymmetric cell divisions in Drosophila
    R Kraut
    Institute of Molecular and Cell Biology, National University of Singapore
    Nature 383:50-5. 1996
  3. ncbi Postsynaptic filopodia in muscle cells interact with innervating motoneuron axons
    S Ritzenthaler
    Department of Cell and Structural Biology, University of Illinois, B605 CLS Laboratory, 601 South Goodwin Ave, Urbana, Illinois 61801, USA
    Nat Neurosci 3:1012-7. 2000
  4. pmc The cell fate determinant numb interacts with EHD/Rme-1 family proteins and has a role in endocytic recycling
    Christian A Smith
    Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8
    Mol Biol Cell 15:3698-708. 2004
  5. ncbi The adult Drosophila posterior midgut is maintained by pluripotent stem cells
    Benjamin Ohlstein
    Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution of Washington, 3520 San Martin Drive, Baltimore, Maryland 21218, USA
    Nature 439:470-4. 2006
  6. ncbi Inscuteable and Staufen mediate asymmetric localization and segregation of prospero RNA during Drosophila neuroblast cell divisions
    P Li
    Developmental Neurobiology Laboratory, Institute of Molecular and Cell Biology, National University of Singapore
    Cell 90:437-47. 1997
  7. ncbi The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts
    Claudia Petritsch
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Dev Cell 4:273-81. 2003
  8. pmc Coordinate control of synaptic-layer specificity and rhodopsins in photoreceptor neurons
    Marta Morey
    Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    Nature 456:795-9. 2008
  9. pmc Postembryonic development of transit amplifying neuroblast lineages in the Drosophila brain
    Natalya Izergina
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Neural Dev 4:44. 2009
  10. pmc Identification of an evolutionarily divergent U11 small nuclear ribonucleoprotein particle in Drosophila
    Claudia Schneider
    Department of Cellular Biochemistry, Max Planck Institute of Biophysical Chemistry, 37077 Goettingen, Germany
    Proc Natl Acad Sci U S A 101:9584-9. 2004

Research Grants

  1. REGIONAL PATTERNING IN THE VENTRAL TELENCEPHALON
    GORDON J FISHELL; Fiscal Year: 2010
  2. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
  3. GENETIC ANALYSIS OF PREHAIR MORPHOGENESIS
    Paul Adler; Fiscal Year: 2005
  4. Organogenesis Screen Using Tissue-Specific Zebrafish
    Jau Nian Chen; Fiscal Year: 2005
  5. Genetic Analysis of Heavy Metals Neurotoxicity
    Fen Biao Gao; Fiscal Year: 2005
  6. Gene Expression Levels Across Diverse Genomes
    Samuel Karlin; Fiscal Year: 2006
  7. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
  8. MOLECULAR SEQUENCE DATA
    Samuel Karlin; Fiscal Year: 2001
  9. Patterning of the Primitive Heart Tube in Zebrafish
    Jau Nian Chen; Fiscal Year: 2010
  10. University of Oregon Animal Resource Improvements
    Judith Eisen; Fiscal Year: 2008

Detail Information

Publications165 found, 100 shown here

  1. ncbi Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells
    Joerg Betschinger
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Cell 124:1241-53. 2006
    ..Similar defects are seen in lethal giant larvae (lgl) mutants where Brat and Prospero are not asymmetric. We have identified a molecular mechanism that may control self-renewal and prevent tumor formation in other stem cells as well...
  2. ncbi Role of inscuteable in orienting asymmetric cell divisions in Drosophila
    R Kraut
    Institute of Molecular and Cell Biology, National University of Singapore
    Nature 383:50-5. 1996
    ..The Inscuteable protein localizes to the apical cell cortex before mitosis, suggesting that Inscuteable functions in establishing polarity for asymmetric cell division...
  3. ncbi Postsynaptic filopodia in muscle cells interact with innervating motoneuron axons
    S Ritzenthaler
    Department of Cell and Structural Biology, University of Illinois, B605 CLS Laboratory, 601 South Goodwin Ave, Urbana, Illinois 61801, USA
    Nat Neurosci 3:1012-7. 2000
    ..Thus, postsynaptic filopodia are capable of intimate interaction with innervating presynaptic axons. We propose that, by contributing to direct long-distance cellular communication, they are dynamically involved in synaptic matchmaking...
  4. pmc The cell fate determinant numb interacts with EHD/Rme-1 family proteins and has a role in endocytic recycling
    Christian A Smith
    Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8
    Mol Biol Cell 15:3698-708. 2004
    ..In addition, we present evidence that Numb has a novel function in endosomal recycling and intracellular trafficking of receptors...
  5. ncbi The adult Drosophila posterior midgut is maintained by pluripotent stem cells
    Benjamin Ohlstein
    Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution of Washington, 3520 San Martin Drive, Baltimore, Maryland 21218, USA
    Nature 439:470-4. 2006
    ..The identification of Drosophila intestinal stem cells with striking similarities to their vertebrate counterparts will facilitate the genetic analysis of normal and abnormal intestinal function...
  6. ncbi Inscuteable and Staufen mediate asymmetric localization and segregation of prospero RNA during Drosophila neuroblast cell divisions
    P Li
    Developmental Neurobiology Laboratory, Institute of Molecular and Cell Biology, National University of Singapore
    Cell 90:437-47. 1997
    ..Stau, as one component of this complex, is required only for RNA localization. Hence staufen also acts zygotically, downstream of inscuteable, to effect aspects of neuroblast asymmetry...
  7. ncbi The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts
    Claudia Petritsch
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Dev Cell 4:273-81. 2003
    ..Our studies demonstrate that a class VI myosin is necessary for basal protein targeting and spindle orientation in neuroblasts...
  8. pmc Coordinate control of synaptic-layer specificity and rhodopsins in photoreceptor neurons
    Marta Morey
    Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    Nature 456:795-9. 2008
    ..We show that R7 targeting requires the R7-specific transcription factor Prospero (Pros) in parallel to repression of the R8 targeting pathway by NF-YC...
  9. pmc Postembryonic development of transit amplifying neuroblast lineages in the Drosophila brain
    Natalya Izergina
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Neural Dev 4:44. 2009
    ..In this report we use MARCM-based clonal analysis together with immunocytochemical labeling techniques to investigate the type and fate of neural cells generated in the DM lineages...
  10. pmc Identification of an evolutionarily divergent U11 small nuclear ribonucleoprotein particle in Drosophila
    Claudia Schneider
    Department of Cellular Biochemistry, Max Planck Institute of Biophysical Chemistry, 37077 Goettingen, Germany
    Proc Natl Acad Sci U S A 101:9584-9. 2004
    ..A comparison of U11 snRNAs that we have identified from vertebrates, plants, and insects, suggests that an evolutionarily divergent U11 snRNA may be unique to Drosophila and not characteristic of insects in general...
  11. ncbi Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster
    Emmanuel Caussinus
    Cell Biology and Biophysics Program, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Genet 37:1125-9. 2005
    ..We found that larval brain tissue carrying neuroblasts with mutations in raps (also called pins), mira, numb or pros grew to more than 100 times their initial size, invading other tissues and killing the hosts in 2 weeks...
  12. ncbi Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal
    Cheng Yu Lee
    Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, 97403, USA
    Dev Cell 10:441-9. 2006
    ..Single neuroblast clones lacking Prospero have a similar phenotype. We conclude that Brat suppresses neuroblast stem cell self-renewal and promotes neuronal differentiation...
  13. ncbi The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila
    Bruno Bello
    Biozentrum, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Development 133:2639-48. 2006
    ..number of cells, which have molecular features of undifferentiated progenitor cells that lack nuclear Prospero (Pros)...
  14. ncbi Spindle orientation and asymmetric cell fate
    M S Rhyu
    National Cancer Institute, Bethesda, Maryland 20892, USA
    Cell 82:523-6. 1995
  15. ncbi Suppression of polyglutamine toxicity by a Drosophila homolog of myeloid leukemia factor 1
    Parsa Kazemi-Esfarjani
    Department of Physiology and Biophysics, Center for Neuroscience, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14214, USA
    Hum Mol Genet 11:2657-72. 2002
    ....
  16. doi AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster
    Satoshi Kametaka
    Department of Anatomy and Histology, Fukushima Medical University, 1 Hikarigaoka, Fukushima, Fukushima 960 1295, Japan
    J Cell Sci 125:634-48. 2012
    ..These results suggest that AP-1 and Aftiphilin are cooperatively involved in the intracellular trafficking of Notch during eye development in Drosophila...
  17. ncbi Rotation and asymmetry of the mitotic spindle direct asymmetric cell division in the developing central nervous system
    J A Kaltschmidt
    Wellcome CRC Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Nat Cell Biol 2:7-12. 2000
    ..This observation contradicts the widely held hypothesis that the cleavage furrow is always placed midway between the two centrosomes...
  18. ncbi Regulation of R7 and R8 differentiation by the spalt genes
    Pedro M Domingos
    Howard Hughes Medical Institute, Strang Laboratory of Cancer Research, The Rockefeller University, New York, NY 10021, USA
    Dev Biol 273:121-33. 2004
    ..Taken together, our results suggest that while spalt is required for R7 differentiation during larval stages, spalt and senseless promote terminal R8 differentiation during pupal stages, including the regulation of rhodopsin expression...
  19. pmc Regulation of spindle orientation and neural stem cell fate in the Drosophila optic lobe
    Boris Egger
    The Wellcome Trust Cancer Research UK Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Neural Dev 2:1. 2007
    ..In some tissues cell fate appears to dictate the type of cell division, whereas in other tissues it is thought that stochastic variation in spindle position dictates subsequent sibling cell fate...
  20. ncbi prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila
    H Vaessin
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0724
    Cell 67:941-53. 1991
    ..prospero encodes a large nuclear protein with multiple homopolymeric amino acid stretches and is expressed in neuronal precursors early during their formation. It is probably generally required for proper neuronal differentiation...
  21. ncbi The prospero gene encodes a divergent homeodomain protein that controls neuronal identity in Drosophila
    Q Chu-LaGraff
    Department of Cell and Structural Biology, University of Illinois, Urbana 61801
    Dev Suppl . 1991
    ..Recently we identified the prospero (pros) gene, which is expressed in embryonic neuroblasts...
  22. ncbi Partner of Numb colocalizes with Numb during mitosis and directs Numb asymmetric localization in Drosophila neural and muscle progenitors
    B Lu
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco 94143 0725, USA
    Cell 95:225-35. 1998
    ..We propose that PON is one component of a multimolecular machinery that localizes Numb by responding to polarity cues conserved in neural precursors and epithelial cells...
  23. ncbi Control of spindle orientation in Drosophila by the Par-3-related PDZ-domain protein Bazooka
    U Kuchinke
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstrasse 1, 40225 Dusseldorf, Germany
    Curr Biol 8:1357-65. 1998
    ..None of the genes identified so far that are involved in these processes seems to have been conserved between flies and nematodes...
  24. ncbi Prospero distinguishes sibling cell fate without asymmetric localization in the Drosophila adult external sense organ lineage
    L Manning
    Howard Hughes Medical Institute, Department of Cell and Structural Biology, University of Illinois, Urbana, IL 61801, USA
    Development 126:2063-71. 1999
    ..Finally, in contrast to previous studies, we find that the IIb cell divides prior to the IIa cell in the SOP lineage...
  25. ncbi Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts
    A Wodarz
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Germany
    Nature 402:544-7. 1999
    ..As Bazooka is also responsible for the maintenance of apical-basal polarity in epithelial tissues, it may be the missing link between epithelial polarity and neuroblast polarity...
  26. ncbi Cell diversity in the retina: more than meets the eye
    Tiffany Cook
    New York University, New York NY 10003, USA
    Bioessays 25:921-5. 2003
    ..As Prospero, the Drosophila homolog of Prox1, also participates in retinal cell specification, these data provide a forum for asking new questions concerning pathways that may regulate retinogenesis across evolution...
  27. ncbi Regulation of temporal identity transitions in Drosophila neuroblasts
    Ruth Grosskortenhaus
    Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon 1254, Eugene, Oregon 97403, USA
    Dev Cell 8:193-202. 2005
    ..We conclude that two distinct "timers" regulate neuroblast gene expression: a hunchback --> Kruppel timer requiring cytokinesis, and a Kruppel --> pdm1 --> castor timer which is cell cycle independent...
  28. pmc Dual roles of Drosophila p53 in cell death and cell differentiation
    Y Fan
    Department of Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Cell Death Differ 17:912-21. 2010
    ..this study, using the developing eye as a model, we show that Dp53-induced apoptosis is primarily dependent on the pro-apoptotic gene, head involution defective (hid), but not reaper (rpr), and occurs through the canonical apoptosis ..
  29. ncbi Cloning of the Drosophila prospero gene and its expression in ganglion mother cells
    F Matsuzaki
    Division of Molecular Genetics, National Institute of Neuroscience, NCNP, Tokyo, Japan
    Biochem Biophys Res Commun 182:1326-32. 1992
    ..Among genes known to control neurogenesis, prospero (pros) was recently identified as a gene required for gene expression specifying properties of some identified neurons...
  30. ncbi The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila
    E P Spana
    Howard Hughes Medical Institute, Department of Cell and Structural Biology, University of Illinois, Urbana 61801, USA
    Development 121:3187-95. 1995
    ..The asymmetric cortical localization of prospero at mitosis is a mechanism for rapidly establishing distinct sibling cell fates in the CNS and possibly other tissues...
  31. ncbi Innervation directs receptor synthesis and localization in Drosophila embryo synaptogenesis
    K Broadie
    Department of Zoology, University of Cambridge, UK
    Nature 361:350-3. 1993
    ..prospero (pros) is not expressed in the muscles or their precursors...
  32. ncbi Control of daughter cell fates during asymmetric division: interaction of Numb and Notch
    M Guo
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0724, USA
    Neuron 17:27-41. 1996
    ..This leads to Ttk expression in the daughter cell that does not inherit Numb. Thus, the inherited determinant Numb bestows a bias in the machinery for cell-cell communication to allow the specification of distinct daughter cell fates...
  33. ncbi Miranda is required for the asymmetric localization of Prospero during mitosis in Drosophila
    C P Shen
    Howard Hughes Medical Institute and Department of Physiology, University of California at San Francisco, 94143 0724, USA
    Cell 90:449-58. 1997
    ..Our results suggest that miranda functions downstream of inscuteable and works as an adapter that connects Prospero to the basal cell membrane during asymmetric cell division...
  34. ncbi Transcription factors in eye development: a gorgeous mosaic?
    J Kumar
    Department of Biological Sciences, University of Southern California, Los Angeles 90089 1340, USA
    Genes Dev 11:2023-8. 1997
  35. pmc The N terminus of the Drosophila Numb protein directs membrane association and actin-dependent asymmetric localization
    J A Knoblich
    Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco 94143 0724, USA
    Proc Natl Acad Sci U S A 94:13005-10. 1997
    ....
  36. ncbi Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisions
    H Ikeshima-Kataoka
    Department of Molecular Genetics, National Institute of Neuroscience, Tokyo, Japan
    Nature 390:625-9. 1997
    ..miranda thus creates intrinsic differences between sibling cells by mediating the asymmetric segregation of a transcription factor into only one daughter cell during neural stem-cell division...
  37. ncbi Only a subset of the binary cell fate decisions mediated by Numb/Notch signaling in Drosophila sensory organ lineage requires Suppressor of Hairless
    S Wang
    Howard Hughes Medical Institute, and Department of Physiology, University of California, San Francisco 94143 0724, USA
    Development 124:4435-46. 1997
    ..These studies reveal that Suppressor of Hairless is required for only a subset of the asymmetric divisions that depend on the function of numb and Notch...
  38. ncbi Frizzled signalling controls orientation of asymmetric sense organ precursor cell divisions in Drosophila
    M Gho
    Laboratoire de Génétique du Développement de la Drosophile, URA 1857, Ecole Normale Superieure, Paris, France
    Nature 393:178-81. 1998
    ..This difference in cell-division orientation is largely independent of the identity of the secondary precursor cells, and is regulated by Frizzled-independent mechanisms...
  39. pmc Miranda mediates asymmetric protein and RNA localization in the developing nervous system
    A J Schuldt
    Wellcome CRC Institute and Department of Genetics, Cambridge CB2 1QR, UK
    Genes Dev 12:1847-57. 1998
    ..Thus Miranda, which localizes Prospero protein, also localizes prospero RNA through its interaction with Staufen protein...
  40. ncbi Revisiting the Drosophila microchaete lineage: a novel intrinsically asymmetric cell division generates a glial cell
    M Gho
    Ecole Normale Superieure, ATIPE URA1857, 75005 Paris, France
    Development 126:3573-84. 1999
    ..This revised description of the sense organ lineage provides the basis for future studies on how polarity and fate are regulated in asymmetrically dividing cells...
  41. ncbi A glial cell arises from an additional division within the mechanosensory lineage during development of the microchaete on the Drosophila notum
    G V Reddy
    Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Rd, Mumbai 400 005 and the National Centre for Biological Sciences, TIFR, Bangalore 560 065, India
    Development 126:4617-22. 1999
    ..The proposed modification in lineage has important implications for previous studies on sibling cell fate choice and cell fate specification in sensory systems...
  42. ncbi Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-related caspase activator
    H Kanuka
    Department of Neuroscience, Osaka University Graduate School of Medicine, Japan
    Mol Cell 4:757-69. 1999
    ..These data suggest that Dapaf-1/cytochrome c-dependent cell death-inducing machinery is present in Drosophila, and the requirement of Dapaf-1/Apaf-1 in neural cell death is conserved through evolution...
  43. pmc Pan-neural Prospero terminates cell proliferation during Drosophila neurogenesis
    L Li
    Department of Molecular Genetics, Ohio State University, Columbus, Ohio 43210 USA
    Genes Dev 14:147-51. 2000
    ..Loss of pros results in aberrant expression of multiple cell-cycle regulatory genes and ectopic mitotic activity...
  44. ncbi Overlapping activators and repressors delimit transcriptional response to receptor tyrosine kinase signals in the Drosophila eye
    C Xu
    Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260, USA
    Cell 103:87-97. 2000
    ..We show that Sevenless activates prospero independent of the enhancer and involves targeted degradation of Tramtrack, a transcription repressor...
  45. ncbi Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast
    T Ohshiro
    CREST, Japan Science and Technology Corporation, Sendai
    Nature 408:593-6. 2000
    ..Thus, Lgl and Dlg act in a common process that differentially mediates cortical protein targeting in mitotic neuroblasts, and that creates intrinsic differences between daughter cells...
  46. ncbi Lineage, cell polarity and inscuteable function in the peripheral nervous system of the Drosophila embryo
    V Orgogozo
    Ecole Normale Superieure, UMR 8544 46, rue d Ulm, 75230 Paris Cedex 05, France
    Development 128:631-43. 2001
    ..This study establishes for the first time the function of Inscuteable in the PNS, and provides the basis for studying the mechanisms controlling planar and apical-basal cell polarities in the embryonic sensory organ lineages...
  47. ncbi Adherens junctions inhibit asymmetric division in the Drosophila epithelium
    B Lu
    Howard Hughes Medical Institute and Department of Physiology, University of California at San Francisco, 94143 0725, USA
    Nature 409:522-5. 2001
    ..Our results indicate that neuroepithelial cells have all the necessary components to execute asymmetric division, but that this pathway is normally overridden by the planar polarity cue provided by adherens junctions...
  48. pmc A family of snail-related zinc finger proteins regulates two distinct and parallel mechanisms that mediate Drosophila neuroblast asymmetric divisions
    Y Cai
    Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore
    EMBO J 20:1704-14. 2001
    ....
  49. ncbi Redundant function of Runt Domain binding partners, Big brother and Brother, during Drosophila development
    J S Kaminker
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Development 128:2639-48. 2001
    ..These studies highlight a mechanism for transcriptional control by a Runt Domain protein and a redundant pair of partners in the specification of cell fate during development...
  50. ncbi Yan regulates Lozenge during Drosophila eye development
    Kristina Jackson Behan
    Department of Biological Sciences, Carnegie Mellon University, Pittsburg, PA 15213, USA
    Dev Genes Evol 212:267-76. 2002
    ..We propose that upregulated Lozenge acts as a cofactor to alter Pointed affinity, by a mechanism that is recapitulated in mammalian development...
  51. ncbi The glial cell undergoes apoptosis in the microchaete lineage of Drosophila
    Pierre Fichelson
    UMR 7622, CNRS Universite Paris VI, 9, quai St Bernard, 75252 Paris Cedex 05, France
    Development 130:123-33. 2003
    ..Fragmentation was blocked after overexpression of the caspase inhibitor p35 or removal of the pro-apoptotic genes reaper, hid and grim, showing that the glial cell undergoes apoptosis...
  52. ncbi Taste, movement, and death: varying effects of new prospero mutants during Drosophila development
    Yael Grosjean
    Unité de Recherche 5548 Associée au Centre National de la Recherche Scientifique, Faculte des Sciences, Universite de Bourgogne, 6, Bd Gabriel, 21 000 Dijon, France
    J Neurobiol 55:1-13. 2003
    ..inserted upstream of the pan-neural gene prospero (pros) causes several neural and behavioral defects in the Voila(1) strain...
  53. ncbi Combinatorial expression of Prospero, Seven-up, and Elav identifies progenitor cell types during sense-organ differentiation in the Drosophila antenna
    Anindya Sen
    Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Rd, Mumbai 400005, India
    Dev Biol 254:79-92. 2003
    ..An understanding of the lineage and development of olfactory sense-organs provides a handle for the analysis of how olfactory neurons acquire distinct terminal fates...
  54. pmc In vivo analysis of a developmental circuit for direct transcriptional activation and repression in the same cell by a Runx protein
    Jude Canon
    Department of Biological Chemistry and Department of Molecular, Cell, and Developmental Biology, Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA
    Genes Dev 17:838-43. 2003
    ..This study provides a mechanistic basis for the dual function of Runx proteins that is likely to be conserved in mammalian systems...
  55. ncbi Drosophila pod-1 crosslinks both actin and microtubules and controls the targeting of axons
    Michael E Rothenberg
    Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, 533 Parnassus Avenue, San Francisco, CA 94143, USA
    Neuron 39:779-91. 2003
    ..Taken together, these results reveal novel activities for pod-1 and show that proper levels of Dpod1, an actin/MT crosslinker, must be maintained in the growth cone for correct axon guidance...
  56. pmc Prospero maintains the mitotic potential of glial precursors enabling them to respond to neurons
    Rachel L Griffiths
    NeuroDevelopment Group, Department of Genetics, University of Cambridge, Cambridge, UK
    EMBO J 23:2440-50. 2004
    ..This enables prospero-expressing cells alone to divide further upon elimination of neurons and to adjust glial number to axons during development...
  57. ncbi Alternative splicing removes an Ets interaction domain from Lozenge during Drosophila eye development
    Kristina Jackson Behan
    University of West Florida, Pensacola 32514, USA
    Dev Genes Evol 215:423-35. 2005
    ..We suggest that during eye development, Lozenge isoforms function in divergent roles, either interacting with Pointed on downstream targets or by functioning independently to establish distinct cell fates...
  58. ncbi Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors
    Hamed Jafar-Nejad
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Dev Cell 9:351-63. 2005
    ..Our data indicate that Sec15 mediates a specific vesicle trafficking event to ensure proper neuronal fate specification in Drosophila...
  59. ncbi Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling
    Benjamin Ohlstein
    Howard Hughes Medical Institute, Department of Embryology, Carnegie Institution of Washington, 3520 San Martin Drive, Baltimore, MD 21218, USA
    Science 315:988-92. 2007
    ..Thus, ISCs control daughter cell fate by modulating Notch signaling over time. Our studies suggest that ISCs actively coordinate cell production with local tissue requirements by this mechanism...
  60. doi Loss of seven-up from Drosophila R1/R6 photoreceptors reveals a stochastic fate choice that is normally biased by Notch
    Adam C Miller
    Institute of Molecular Biology, University of Oregon, 1370 Franklin Blvd, Eugene, OR 97403, USA
    Development 135:707-15. 2008
    ..We show that N specifies the R7 fate by a novel branched pathway: N represses Svp expression, thereby exposing an underlying stochastic choice between the R7 and R8 fates, and then tips this choice towards the R7 fate...
  61. doi A conserved nuclear receptor, Tailless, is required for efficient proliferation and prolonged maintenance of mushroom body progenitors in the Drosophila brain
    Mitsuhiko Kurusu
    Structural Biology Center, National Institute of Genetics, and Department of Genetics, The Graduate University for Advanced Studies, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Dev Biol 326:224-36. 2009
    ..These results as a whole uncover a distinct regulatory mechanism of self-renewal and differentiation of the MB progenitors that is different from the mechanisms found in other progenitors...
  62. ncbi The prospero gene specifies cell fates in the Drosophila central nervous system
    C Q Doe
    Department of Cell and Structural Biology, University of Illinois, Urbana 61801
    Cell 65:451-64. 1991
    ..prospero is therefore a novel type of gene expressed in neuroblasts and known to specify neuronal fate...
  63. ncbi Asymmetric segregation of Numb and Prospero during cell division
    J A Knoblich
    Howard Hughes Medical Institute, University of California at San Francisco 94143 0724, USA
    Nature 377:624-7. 1995
    ..We propose that there is an organizer of asymmetric cell division which provides positional information for both the orientation of the mitotic spindle and asymmetric localization of Numb and Prospero...
  64. ncbi tramtrack acts downstream of numb to specify distinct daughter cell fates during asymmetric cell divisions in the Drosophila PNS
    M Guo
    Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco 94143, USA
    Neuron 14:913-25. 1995
    ..Epistatic studies suggest that ttk acts downstream of numb. We propose that ttk executes the command dictated by asymmetrically localized numb to specify distinct daughter cell fates during multiple asymmetric divisions...
  65. ncbi inscuteable, a neural precursor gene of Drosophila, encodes a candidate for a cytoskeleton adaptor protein
    R Kraut
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Cologne, Germany
    Dev Biol 174:65-81. 1996
    ..The inscuteable mutant phenotype, together with these other observations, suggests a possible role for the protein in cytoskeleton organization...
  66. ncbi Ras1 signaling and transcriptional competence in the R7 cell of Drosophila
    R C Kauffmann
    Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260, USA
    Genes Dev 10:2167-78. 1996
    ..Our results suggest that specific transcriptional responses are linked to the mode of activation of the Ras1/MAP kinase signal transduction pathway...
  67. ncbi Extrinsic cues, intrinsic cues and microfilaments regulate asymmetric protein localization in Drosophila neuroblasts
    J Broadus
    Department of Cell and Structural Biology, Howard Hughes Medical Institute, University of Illinois, Urbana 61801, USA
    Curr Biol 7:827-35. 1997
    ..Here we use in vitro culture of neuroblasts to investigate the role of intrinsic and extrinsic cues and the cytoskeleton in asymmetric localization of Inscuteable, Prospero and Staufen proteins...
  68. ncbi Staufen-dependent localization of prospero mRNA contributes to neuroblast daughter-cell fate
    J Broadus
    Department of Cell and Structural Biology, Howard Hughes Medical Institute, University of Illinois, Urbana 61801, USA
    Nature 391:792-5. 1998
    ..The prospero (pros) mRNA and the RNA-binding protein Staufen (Stau) are asymmetrically localized in mitotic neuroblasts and are ..
  69. ncbi The Drosophila sanpodo gene controls sibling cell fate and encodes a tropomodulin homolog, an actin/tropomyosin-associated protein
    C A Dye
    Department of Cell Biology, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
    Development 125:1845-56. 1998
    ..Loss of sanpodo leads to an aberrant F-actin distribution and causes differentiation defects of actin-containing sensory structures. Our data suggest that an actin-based process is involved in Notch signaling...
  70. ncbi Asymmetric cell division
    Y N Jan
    Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, 94143 0725, USA
    Nature 392:775-8. 1998
    ....
  71. pmc Binary sibling neuronal cell fate decisions in the Drosophila embryonic central nervous system are nonstochastic and require inscuteable-mediated asymmetry of ganglion mother cells
    M Buescher
    Institute of Molecular and Cell Biology, National University of Singapore, Singapore
    Genes Dev 12:1858-70. 1998
    ..Moreover, our data suggest that the fate of some sibling neurons may be regulated by signals that do not require lateral interaction between the sibling cells...
  72. ncbi miranda localizes staufen and prospero asymmetrically in mitotic neuroblasts and epithelial cells in early Drosophila embryogenesis
    F Matsuzaki
    Department of Molecular Genetics, National Institute of Neuroscience, NCNP, Kodaira, Tokyo 187, Japan
    Development 125:4089-98. 1998
    ..Our observations suggest that the epithelial cell and neuroblast (both of epithelial origin) share the same molecular machinery for creating cellular asymmetry...
  73. ncbi Biochemical analysis of ++Prospero protein during asymmetric cell division: cortical Prospero is highly phosphorylated relative to nuclear Prospero
    S Srinivasan
    Department of Cell and Structural Biology, HHMI, Urbana, Illinois, 61801, USA
    Dev Biol 204:478-87. 1998
    ....
  74. ncbi Asymmetric cell division of thoracic neuroblast 6-4 to bifurcate glial and neuronal lineage in Drosophila
    Y Akiyama-Oda
    Department of Physics, Graduate School of Science and Molecular Genetics Laboratory, University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033 Japan
    Development 126:1967-74. 1999
    ..Our observations suggest that mechanisms regulating gcm mRNA expression and its translation play an important role in glial and neuronal lineage bifurcation that results from asymmetric cell division...
  75. ncbi Sibling cell fate in the Drosophila adult external sense organ lineage is specified by prospero function, which is regulated by Numb and Notch
    G V Reddy
    Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Rd, Mumbai 400005, India
    Development 126:2083-92. 1999
    ..We show that the homeodomain transcription factor Prospero (Pros) acts as an intrinsic signal for the specification of cell fates within the mechanosensory lineage...
  76. ncbi Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization
    F Yu
    Institute of Molecular and Cell Biology, National University of Singapore, Singapore
    Cell 100:399-409. 2000
    ....
  77. ncbi Chip is an essential cofactor for apterous in the regulation of axon guidance in Drosophila
    D J van Meyel
    The Salk Institute for Biological Studies, PO Box 85800, San Diego, CA 92186, USA
    Development 127:1823-31. 2000
    ....
  78. ncbi Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila
    R Nolo
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 102:349-62. 2000
    ..Sens is then in turn required to further activate and maintain proneural gene expression. This feedback mechanism is essential for selective enhancement and maintenance of proneural gene expression in the SOPs...
  79. ncbi Developmental biology. Control by combinatorial codes
    A Ghazi
    Nature 408:419-20. 2000
  80. ncbi Asymmetric cell division: fly neuroblast meets worm zygote
    C Q Doe
    Institute of Molecular Biology, Institute of Neuroscience, Howard Hughes Medical Institute, 1254 University of Oregon, Eugene, Oregon 97403, USA
    Curr Opin Cell Biol 13:68-75. 2001
    ..Mammalian epithelia also use this complex to regulate apical/basal polarity. Recent results have allowed us to compare the mechanisms regulating asymmetric cell division in Drosophila neuroblasts and the C. elegans zygote...
  81. ncbi Translational repression determines a neuronal potential in Drosophila asymmetric cell division
    M Okabe
    Division of Developmental Genetics, National Institute of Genetics, and Department of Genetics, Graduate University for Advanced Studies, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Nature 411:94-8. 2001
    ..Thus, Notch signalling is likely to regulate MSI activity rather than its expression. Our results define cell-type-specific translational control of ttk69 by MSI as a downstream event of Notch signalling in asymmetric cell division...
  82. ncbi Transcription of the Drosophila CKI gene dacapo is regulated by a modular array of cis-regulatory sequences
    Te Hui Liu
    Department of Molecular Genetics, Neurobiotechnology Center, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Mech Dev 112:25-36. 2002
    ..Furthermore, we identified pan-neural Prospero as a regulator of dap transcription in the developing nervous system, providing an example how tissue-specific developmental programs can be linked to cell cycle progression...
  83. ncbi Apical complex genes control mitotic spindle geometry and relative size of daughter cells in Drosophila neuroblast and pI asymmetric divisions
    Yu Cai
    Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Singapore
    Cell 112:51-62. 2003
    ..In sensory organ precursors, Bazooka/DaPKC and Pins/G alpha i localize to opposite sides of the cortex and function in opposition to generate a symmetric spindle...
  84. ncbi Heterotrimeric G proteins regulate daughter cell size asymmetry in Drosophila neuroblast divisions
    Naoyuki Fuse
    Laboratory for Cell Asymmetry, Center for Developmental Biology, RIKEN, Chuou ku, Kobe 650 0047, Japan
    Curr Biol 13:947-54. 2003
    ..Furthermore, the multiple equal cleavages of G beta mutant neuroblasts accompany neural defects; this finding suggests indispensable roles of eccentric division in assuring the stem cell properties of neuroblasts...
  85. ncbi Distinction between color photoreceptor cell fates is controlled by Prospero in Drosophila
    Tiffany Cook
    Department of Biology, New York University, 1009 Main Building, 100 Washington Square East, New York, NY 10003, USA
    Dev Cell 4:853-64. 2003
    ..that several aspects of R7 versus R8 cell fate determination are regulated by the transcription factor Prospero (Pros)...
  86. ncbi Drosophila nonmuscle myosin II promotes the asymmetric segregation of cell fate determinants by cortical exclusion rather than active transport
    Claudia S Barros
    Wellcome Trust Cancer Research UK Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Dev Cell 5:829-40. 2003
    ..Therefore, the movement of myosin II to the contractile ring not only initiates cytokinesis but also completes the partitioning of cell fate determinants from the neuroblast to its daughter...
  87. ncbi Dare to be different: asymmetric cell division in Drosophila, C. elegans and vertebrates
    Jörg Betschinger
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Curr Biol 14:R674-85. 2004
    ..Here, we outline the steps and factors that are involved in this process in Drosophila and C. elegans and discuss their potential conservation in vertebrates...
  88. ncbi Building a retinal mosaic: cell-fate decision in the fly eye
    Mathias F Wernet
    Center for Developmental Genetics, Department of Biology, New York University, 100 Washington Place, New York, NY 10003, USA
    Trends Cell Biol 14:576-84. 2004
    ..Notably, several of the factors used in generating the retinal mosaic of the fruitfly have corresponding functions in vertebrates that are likely to have similar roles...
  89. ncbi Temporal control of differentiation by the insulin receptor/tor pathway in Drosophila
    Joseph M Bateman
    Cancer Research UK, 44 Lincoln s Inn Fields, London, WC2A 3PX, England
    Cell 119:87-96. 2004
    ..These data suggest that intricate developmental decisions are coordinated with nutritional status and tissue growth by the InR signaling pathway...
  90. ncbi Mother-daughter precursor cell fate transformation after Cdc2 down-regulation in the Drosophila bristle lineage
    Pierre Fichelson
    UMR 7622, CNRS Universite Paris VI, 9, quai St Bernard, 75252 Paris Cedex 05, France
    Dev Biol 276:367-77. 2004
    ..These transformations in cell identity suggest that, although synchronized, cell cycle and fate determination are independent phenomena in the bristle lineage...
  91. ncbi Localization-dependent and -independent roles of numb contribute to cell-fate specification in Drosophila
    Sheetal Bhalerao
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Curr Biol 15:1583-90. 2005
    ..Our results suggest that two classes of asymmetric cell division exist, each with different requirements for asymmetric inheritance of cell-fate determinants...
  92. ncbi Regulation of post-embryonic neuroblasts by Drosophila Grainyhead
    Mara S Almeida
    Department of Anatomy, University of Cambridge, Downing Street, CA CB2 3DY, UK
    Mech Dev 122:1282-93. 2005
    ..Thus one way Grh could regulate pNBs is through expression of E-cadherin, a protein that is thought to mediate interactions with the glial niche...
  93. ncbi Evidence that stem cells reside in the adult Drosophila midgut epithelium
    Craig A Micchelli
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 439:475-9. 2006
    ..The ability to identify, manipulate and genetically trace cell lineages in the midgut should lead to the discovery of additional genes that regulate stem and progenitor cell biology in the gastrointestinal tract...
  94. ncbi A primary cell culture of Drosophila postembryonic larval neuroblasts to study cell cycle and asymmetric division
    Julian Ceron
    Instituto de Neurociencias, CSIC and Universidad Miguel Hernandez, San Juan, E 03550 Alicante, Spain
    Eur J Cell Biol 85:567-75. 2006
    ..The combination of this cell culture system and genetic tools of Drosophila will provide a powerful experimental model for the analysis of cell cycle and asymmetric cell division of neural progenitor cells...
  95. pmc Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts
    Hongyan Wang
    Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore 117604
    Genes Dev 20:3453-63. 2006
    ..We have identified a novel mechanism for controlling the balance between self-renewal and neuronal differentiation during the asymmetric division of Drosophila larval NBs...
  96. pmc Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation
    Cheng Yu Lee
    Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, Oregon 97403, USA
    Genes Dev 20:3464-74. 2006
    ..We conclude that Aurora-A and Numb are novel inhibitors of neuroblast self-renewal and that spindle orientation regulates neuroblast self-renewal...
  97. pmc Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC
    Scott X Atwood
    Institute of Molecular Biology and Department of Chemistry, University of Oregon, Eugene, OR 97403, USA
    J Cell Sci 120:3200-6. 2007
    ..We conclude that Cdc42 regulates aPKC localization and activity downstream of Bazooka, thereby directing neuroblast cell polarity and asymmetric cell division...
  98. pmc Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon
    Hongyan Wang
    Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore 117604
    Nature 449:96-100. 2007
    ..Our results reveal a biochemical link between the cell cycle and the asymmetric protein localization machinery, and indicate that Polo can inhibit progenitor self-renewal by regulating the localization and function of Numb...
  99. ncbi Senseless functions as a molecular switch for color photoreceptor differentiation in Drosophila
    Baotong Xie
    Department of Pediatric Ophthalmology, Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Development 134:4243-53. 2007
    ..This repression is mediated by the transcription factor Prospero (Pros)...
  100. pmc In vivo induction of postsynaptic molecular assembly by the cell adhesion molecule Fasciclin2
    Hiroshi Kohsaka
    Department of Physics, Graduate School of Science, Graduate School of Frontier Sciences, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    J Cell Biol 179:1289-300. 2007
    ..We propose that Fas2 mediates trans-synaptic adhesion, which contributes to postsynaptic molecular assembly at the onset of synaptogenesis...
  101. pmc Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor
    Na Hyun Choi
    Department of Molecular Biology, College of Natural Science, Pusan National University, Busan 609 735, South Korea
    Aging Cell 7:318-34. 2008
    ..Taken together, our findings suggest that PDGF/VEGF may play a central role in age-related changes in ISCs and progenitor cell populations, which may contribute to aging and the development of cancer stem cells...

Research Grants18

  1. REGIONAL PATTERNING IN THE VENTRAL TELENCEPHALON
    GORDON J FISHELL; Fiscal Year: 2010
    ..If we can understand how this population is generated, we will take the first step towards assessing whether we can use gene or cell therapies to ameliorate the devasting consequences associated with cortical interneuron dysfunction. ..
  2. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
    ....
  3. GENETIC ANALYSIS OF PREHAIR MORPHOGENESIS
    Paul Adler; Fiscal Year: 2005
    ....
  4. Organogenesis Screen Using Tissue-Specific Zebrafish
    Jau Nian Chen; Fiscal Year: 2005
    ..Mutations identified from this screen will provide entry points to dissect genetic and molecular pathways involved in vertebrate organogenesis. ..
  5. Genetic Analysis of Heavy Metals Neurotoxicity
    Fen Biao Gao; Fiscal Year: 2005
    ....
  6. Gene Expression Levels Across Diverse Genomes
    Samuel Karlin; Fiscal Year: 2006
    ..A third major objective of our research will be to extend our codon usage methods for predicting gene expression levels to eukaryotic genomes, including yeast, D. melanogaster, C. elegans, and human. [unreadable] [unreadable]..
  7. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
    ....
  8. MOLECULAR SEQUENCE DATA
    Samuel Karlin; Fiscal Year: 2001
    ..by spacings between repeats, and by properties of repeat families (intergenic, coding, direct, inverted, mixed). ..
  9. Patterning of the Primitive Heart Tube in Zebrafish
    Jau Nian Chen; Fiscal Year: 2010
    ..The combination of cellular, molecular and genetic studies proposed in this project will provide new and in-depth insight into mechanisms of primitive heart tube morphogenesis. ..
  10. University of Oregon Animal Resource Improvements
    Judith Eisen; Fiscal Year: 2008
    ..This will significantly increase our ability to ensure the health of our many genetically-distinct, and therefore irreplaceable lines of stickleback. [unreadable] [unreadable] [unreadable]..
  11. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
    ..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
  12. Animal Models For Studying Angelman Syndrome, A Developmental Brain Disorder
    Fen Biao Gao; Fiscal Year: 2008
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page J Description, [unreadable] [unreadable]..
  13. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  14. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  15. Molecular and genetic analysis of sanpodo
    James B Skeath; Fiscal Year: 2010
    ..Such insight should help us understand the etiology of diseases in which this process is de-regulated and design new methods to treat these diseases. ..
  16. DEVELOPMENT OF IDENTIFIED MOTONEURONS
    Judith Eisen; Fiscal Year: 2007
    ..Our proposed studies will provide insights that should facilitate new therapies for treatment of motoneuron diseases and injury. ..
  17. MOLECULAR GENETIC ANALYSIS OF ASYMMETRIC CELL DIVISIONS
    Chris Doe; Fiscal Year: 2002
    ..We will do RNA and protein localization studies; our collaborator, Dr. G. Oliver will generate and assay the gene knock-out mice. ..
  18. MECHANISMS OF NEURAL PATTERNING IN MAMMALIAN FOREBRAIN
    Gordon Fishell; Fiscal Year: 2007
    ..abstract_text> ..