prd

Summary

Gene Symbol: prd
Description: paired
Alias: CG6716, Dmel\CG6716, PRD, Prd, CG6716 gene product from transcript CG6716-RB, CG6716-PA, CG6716-PB, prd-PA, prd-PB
Species: fruit fly

Top Publications

  1. ncbi Mutations affecting the stability of the fushi tarazu protein of Drosophila
    K A Kellerman
    Department of Biology, Washington University, St Louis, Missouri 63130
    Genes Dev 4:1936-50. 1990
  2. pmc The role of localization of bicoid RNA in organizing the anterior pattern of the Drosophila embryo
    T Berleth
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, FRG
    EMBO J 7:1749-56. 1988
  3. ncbi Dissection of the Drosophila paired protein: functional requirements for conserved motifs
    J Cai
    Department of Biology, Wesleyan University, Middletown, CT 06459
    Mech Dev 47:139-50. 1994
  4. pmc Separable regulatory elements mediate the establishment and maintenance of cell states by the Drosophila segment-polarity gene gooseberry
    X Li
    Institute for Molecular Biology II, University of Zurich, Switzerland
    EMBO J 12:1427-36. 1993
  5. ncbi The origin and evolution of segmentation
    G K Davis
    Committee on Developmental Biology, University of Chicago, Chicago, IL 60637, USA
    Trends Cell Biol 9:M68-72. 1999
  6. pmc Small bristles, the Drosophila ortholog of NXF-1, is essential for mRNA export throughout development
    G S Wilkie
    Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Scotland, United Kingdom
    RNA 7:1781-92. 2001
  7. ncbi Groucho-dependent repression by sloppy-paired 1 differentially positions anterior pair-rule stripes in the Drosophila embryo
    Luiz P Andrioli
    Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Dev Biol 276:541-51. 2004
  8. ncbi Boundaries and fields in early embryos
    P W Ingham
    Department of Zoology, University of Oxford, England
    Cell 68:221-35. 1992
  9. ncbi Concentration-dependent activities of the even-skipped protein in Drosophila embryos
    A S Manoukian
    Banting and Best Department of Medical Research, University of Toronto, C H Best Institute, Ontario, Canada
    Genes Dev 6:1740-51. 1992
  10. ncbi The paired box encodes a second DNA-binding domain in the paired homeo domain protein
    J Treisman
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
    Genes Dev 5:594-604. 1991

Patents

  1. Recombinant fowlpox virus with intact FPV-tk-gene

Scientific Experts

Detail Information

Publications114 found, 100 shown here

  1. ncbi Mutations affecting the stability of the fushi tarazu protein of Drosophila
    K A Kellerman
    Department of Biology, Washington University, St Louis, Missouri 63130
    Genes Dev 4:1936-50. 1990
    ..Both ftz transcript and protein stripes are persistent in Rpl embryos, suggesting that the Rpl RNA is stabilized relative to wild type...
  2. pmc The role of localization of bicoid RNA in organizing the anterior pattern of the Drosophila embryo
    T Berleth
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, FRG
    EMBO J 7:1749-56. 1988
    ..The major transcript of 2.6 kb includes a homeobox with low homology to previously known homeoboxes, a PRD-repeat and a M-repeat. In situ hybridizations reveal that bcd is transcribed in the nurse cells...
  3. ncbi Dissection of the Drosophila paired protein: functional requirements for conserved motifs
    J Cai
    Department of Biology, Wesleyan University, Middletown, CT 06459
    Mech Dev 47:139-50. 1994
    The Drosophila paired gene encodes three conserved motifs: a homeodomain, paired domain and PRD (his/pro) repeat...
  4. pmc Separable regulatory elements mediate the establishment and maintenance of cell states by the Drosophila segment-polarity gene gooseberry
    X Li
    Institute for Molecular Biology II, University of Zurich, Switzerland
    EMBO J 12:1427-36. 1993
    ..The significance of such a regulatory strategy is discussed with respect to the establishment and maintenance of cell states within each segment by segment-polarity genes...
  5. ncbi The origin and evolution of segmentation
    G K Davis
    Committee on Developmental Biology, University of Chicago, Chicago, IL 60637, USA
    Trends Cell Biol 9:M68-72. 1999
    ..This article reviews what is known about the segmentation process and considers various proposals to explain its evolution...
  6. pmc Small bristles, the Drosophila ortholog of NXF-1, is essential for mRNA export throughout development
    G S Wilkie
    Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Scotland, United Kingdom
    RNA 7:1781-92. 2001
    ..We conclude that NXF-1 is an essential ubiquitous export factor for all mRNAs throughout development in higher eukaryotes...
  7. ncbi Groucho-dependent repression by sloppy-paired 1 differentially positions anterior pair-rule stripes in the Drosophila embryo
    Luiz P Andrioli
    Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Dev Biol 276:541-51. 2004
    ..The Slp1 protein contains a protein motif (EH1) which mediates binding to the transcriptional corepressor Groucho (Gro). We show that this domain is required for Slp1-mediated repression in vivo...
  8. ncbi Boundaries and fields in early embryos
    P W Ingham
    Department of Zoology, University of Oxford, England
    Cell 68:221-35. 1992
  9. ncbi Concentration-dependent activities of the even-skipped protein in Drosophila embryos
    A S Manoukian
    Banting and Best Department of Medical Research, University of Toronto, C H Best Institute, Ontario, Canada
    Genes Dev 6:1740-51. 1992
    ..Four sequential phenotypes could be induced, each of which was attributable to the altered expression of a unique subset of target genes...
  10. ncbi The paired box encodes a second DNA-binding domain in the paired homeo domain protein
    J Treisman
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
    Genes Dev 5:594-604. 1991
    ..The paired box is another conserved sequence motif, first identified in the paired (prd) and gooseberry (gsb) Drosophila homeo domain genes...
  11. ncbi Network of interactions among pair-rule genes regulating paired expression during primordial segmentation of Drosophila
    S Baumgartner
    Institute of Molecular Biology II, University of Zurich, Switzerland
    Mech Dev 33:1-18. 1990
    A model of the trans-regulation of the Drosophila pair-rule segmentation gene, paired (prd), has been derived from the observed alterations in the distribution of prd transcripts during early embryogenesis in single and double pair-rule ..
  12. ncbi A single amino acid can determine the DNA binding specificity of homeodomain proteins
    J Treisman
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021 6399
    Cell 59:553-62. 1989
    ..by making a series of mutations in the helix-turn-helix motif of the Drosophila homeodomain protein Paired (Prd). This protein does not recognize sequences bound by the homeodomain proteins Fushi tarazu (Ftz) or Bicoid (Bcd)...
  13. pmc Isolation of two tissue-specific Drosophila paired box genes, Pox meso and Pox neuro
    D Bopp
    Department of Cell Biology, Biocenter of the University, Basel, Switzerland
    EMBO J 8:3447-57. 1989
    ..in the central and peripheral nervous system, (ii) nuclear localization of their proteins, (iii) dependence on prd activity and (iv) presence of the paired domain in genes of known regulatory activity...
  14. ncbi Structure of the segmentation gene paired and the Drosophila PRD gene set as part of a gene network
    G Frigerio
    Cell 47:735-46. 1986
    ..In addition to the prd-specific his-pro repeat, some of the 12 genes contain M-repeats and two new types of homeo boxes not detectable by ..
  15. ncbi Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila
    D Bopp
    Cell 47:1033-40. 1986
    ..Thus, together with the PRD repeat, the paired gene contains at least three different domains, each defining a gene set thought to be important ..
  16. ncbi Complementary patterns of even-skipped and fushi tarazu expression involve their differential regulation by a common set of segmentation genes in Drosophila
    M Frasch
    Department of Biological Sciences, Fairchild Center, Columbia University, New York, New York 10027
    Genes Dev 1:981-95. 1987
    ....
  17. ncbi Establishment and refinement of segmental pattern in the Drosophila embryo: spatial control of engrailed expression by pair-rule genes
    S DiNardo
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143
    Genes Dev 1:1212-25. 1987
    ....
  18. ncbi Mutations affecting segment number and polarity in Drosophila
    C Nusslein-Volhard
    Nature 287:795-801. 1980
    ....
  19. ncbi Crystal structure of a paired domain-DNA complex at 2.5 A resolution reveals structural basis for Pax developmental mutations
    W Xu
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Cell 80:639-50. 1995
    The 2.5 A resolution structure of a cocrystal containing the paired domain from the Drosophila paired (prd) protein and a 15 bp site shows structurally independent N-terminal and C-terminal subdomains...
  20. ncbi Multiple regulatory elements direct the complex expression pattern of the Drosophila segmentation gene paired
    T Gutjahr
    Institute for Molecular Biology II, University of Zurich, Switzerland
    Mech Dev 48:119-28. 1994
    The paired (prd) gene of Drosophila belongs to the pair-rule class of segmentation genes involved in establishing the metameric organization of the Drosophila body plan...
  21. ncbi Evolution and role of Pax genes
    M Noll
    Institute for Molecular Biology II, University of Zurich, Switzerland
    Curr Opin Genet Dev 3:595-605. 1993
    ..Their developmental roles are assessed in terms of their participation in conserved gene networks and mechanisms that establish positional information...
  22. ncbi Complex regulation of early paired expression: initial activation by gap genes and pattern modulation by pair-rule genes
    T Gutjahr
    Institute of Molecular Biology II, University of Zurich, Switzerland
    Development 117:609-23. 1993
    ..The factors activating paired expression in the pair-rule mode appear to interact with those activating it along the dorsoventral axis...
  23. pmc Early even-skipped stripes act as morphogenetic gradients at the single cell level to establish engrailed expression
    M Fujioka
    Jefferson Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Development 121:4371-82. 1995
    ..In addition, we show that the early eve gradient is sufficient, at its posterior edge, for subdividing the ftz domain into engrailed expressing and non-expressing cells...
  24. pmc The functional conservation of proteins in evolutionary alleles and the dominant role of enhancers in evolution
    L Xue
    Institute for Molecular Biology II, University of Zurich, Switzerland
    EMBO J 15:3722-31. 1996
    Drosophila paired- embryos can be rescued to viable adults by the evolutionary alleles prd-Gsb and prd-Pax3, which express the Drosophila Gooseberry and mouse Pax3 proteins under the control of the paired cis-regulatory region...
  25. ncbi Cooperative interactions between paired domain and homeodomain
    S Jun
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Development 122:2639-50. 1996
    ..However, prd function in vivo requires the synergistic action of both the PAI domain and the HD...
  26. ncbi In vivo requirement for the paired domain and homeodomain of the paired segmentation gene product
    C Bertuccioli
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Development 122:2673-85. 1996
    ..It encodes a protein containing three conserved motifs: a homeodomain (HD), a paired domain (PD) and a PRD (His/Pro) repeat...
  27. ncbi Drosophila Paired regulates late even-skipped expression through a composite binding site for the paired domain and the homeodomain
    M Fujioka
    Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Development 122:2697-707. 1996
    ..We report here that paired (prd), a pair-rule gene which had been considered to be below eve in the regulatory hierarchy of pair-rule genes, in ..
  28. ncbi Rapid preparation of a panel of polyclonal antibodies to Drosophila segmentation proteins
    D Kosman
    Brookdale Center for Molecular Biology, Box 1126, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Genes Evol 208:290-4. 1998
    ..Antigenicity of the purified recombinant proteins may be increased by precipitation in double-distilled water. The results of using the serums obtained for fluorescent staining of Drosophila embryos are shown...
  29. pmc A comparison of in vivo and in vitro DNA-binding specificities suggests a new model for homeoprotein DNA binding in Drosophila embryos
    A Carr
    Department of Molecular Biophysics and Biochemistry, Yale University, PO Box 208114, New Haven, CT 06520 8114, USA
    EMBO J 18:1598-608. 1999
    ..These genes are bound poorly in vivo, even though they contain many high affinity homeoprotein-binding sites. Based on these results, we suggest how the in vivo pattern of homeoprotein DNA binding is determined...
  30. pmc Analysis of an even-skipped rescue transgene reveals both composite and discrete neuronal and early blastoderm enhancers, and multi-stripe positioning by gap gene repressor gradients
    M Fujioka
    Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Development 126:2527-38. 1999
    ..Additionally, a strong pairing-sensitive repression element was localized to the 3' end of the locus, but was not found to contribute to efficient functional rescue...
  31. pmc Drosophila female sexual behavior induced by sterile males showing copulation complementation
    L Xue
    Institute for Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 97:3272-5. 2000
    ..Our observations may have important implications for the role of sexual behavior in evolution and for the treatment of male sexual dysfunction in humans...
  32. ncbi Combinatorial activity of pair-rule proteins on the Drosophila gooseberry early enhancer
    M Bouchard
    Centre de recherche de L Hôtel Dieu de Québec, Canada
    Dev Biol 222:135-46. 2000
    ..The transcription factor Paired (Prd) is the main activator of this enhancer in all parasegments of the embryo...
  33. ncbi Multiple protein functions of paired in Drosophila development and their conservation in the Gooseberry and Pax3 homologs
    L Xue
    Institute for Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Development 128:395-405. 2001
    ..Both DNA-binding domains, the conserved N-terminal paired-domain and prd-type homeodomain, are required within the same molecule for all general paired functions, whereas a conserved His-..
  34. ncbi Two new roles for the Drosophila AP patterning system in early morphogenesis
    J T Blankenship
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Development 128:5129-38. 2001
    ..Our results therefore suggest a link between cytoskeletal organization during cellularization and subsequent morphogenetic processes of gastrulation...
  35. ncbi Dual role of the Pax gene paired in accessory gland development of Drosophila
    Lei Xue
    Institute for Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Development 129:339-46. 2002
    ..Both Paired functions are absolutely required for male fertility, and both depend on an enhancer located within 0.8 kb of the downstream region of paired...
  36. ncbi Sperm death and dumping in Drosophila
    Rhonda R Snook
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, UK
    Nature 428:939-41. 2004
    ..Instead, males may cause stored sperm to be dumped or females may differentially eject sperm from the previous mating...
  37. pmc Three-dimensional morphology and gene expression in the Drosophila blastoderm at cellular resolution I: data acquisition pipeline
    Cris L Luengo Hendriks
    Berkeley Drosophila Transcription Network Project, Life Sciences Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, CA 94720, USA
    Genome Biol 7:R123. 2006
    ..To model and thoroughly understand animal transcription networks, it is essential to derive accurate spatial and temporal descriptions of developing gene expression patterns with cellular resolution...
  38. pmc Characterization of the Drosophila segment determination morphome
    Svetlana Surkova
    Department of Computational Biology, Center for Advanced Studies, St Petersburg State Polytechnical University, 29 Polytehnicheskaya Street, St Petersburg, 195251, Russia
    Dev Biol 313:844-62. 2008
    ..As the first quantitatively characterized morphogenetic field, this system and its behavior constitute an extraordinarily rich set of materials for the study of canalization and embryonic regulation at the molecular level...
  39. pmc Developmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regions
    Stewart MacArthur
    Genomics Division, Lawrence Berkeley National Laboratory, Cyclotron Road MS 84 181, Berkeley, CA 94720, USA
    Genome Biol 10:R80. 2009
    ....
  40. pmc Quantitative models of the mechanisms that control genome-wide patterns of transcription factor binding during early Drosophila development
    Tommy Kaplan
    Department of Molecular and Cell Biology, California Institute of Quantitative Biosciences, University of California Berkeley, Berkeley, California, United States of America
    PLoS Genet 7:e1001290. 2011
    ....
  41. ncbi Gap gene properties of the pair-rule gene runt during Drosophila segmentation
    C Tsai
    Department of Biochemistry and Cell Biology, State University of New York at Stony Brook 11794 5215
    Development 120:1671-83. 1994
    ..Finally, genetic experiments demonstrated that regulation of gap gene expression by runt is a normal component of the regulatory program that generates the segmented body pattern of the Drosophila embryo...
  42. ncbi Dynamic changes in the functions of Odd-skipped during early Drosophila embryogenesis
    B Saulier-Le Drean
    Banting and Best Department of Medical Research, Charles H Best Institute, University of Toronto, Toronto, Ontario, Canada, M5G 1L6
    Development 125:4851-61. 1998
    ..Based on these results, and the segmental phenotypes generated by ectopic Odd, we suggest a number of new roles for Odd in the patterning of embryonic segments. These include gap-, pair-rule- and segment polarity-type functions...
  43. ncbi Segmenting the fly embryo: a logical analysis of the pair-rule cross-regulatory module
    Lucas Sanchez
    Centro de Investigaciones Biologicas, Velazquez 144, 28006 Madrid, Spain
    J Theor Biol 224:517-37. 2003
    ..Finally, it provides new insights into the roles and evolutionary origins of the apparent redundancies in the regulatory architecture of the pair-rule module...
  44. pmc Distance preferences in the arrangement of binding motifs and hierarchical levels in organization of transcription regulatory information
    Vsevolod J Makeev
    Scientific Center Genetika, Moscow 113545, Russia
    Nucleic Acids Res 31:6016-26. 2003
    ..We discuss the role of the hierarchy in understanding transcriptional regulation and in detection of transcription regulatory regions in genomes...
  45. ncbi Targeted localized degradation of Paired protein in Drosophila development
    L Raj
    Department of Biology, Wesleyan University, Middletown, Connecticut 06459, USA
    Curr Biol 10:1265-72. 2000
    ..Selective spatial regulation of gene expression lies at the core of pattern formation in the embryo. In the fruit fly Drosophila, localized transcriptional regulation accounts for much of the embryonic pattern...
  46. ncbi Zygotically active genes that affect the spatial expression of the fushi tarazu segmentation gene during early Drosophila embryogenesis
    S B Carroll
    Cell 45:113-26. 1986
    ..No simple regulatory relationships can be deduced. Rather, expression of the ftz gene depends upon the interactions among the different segmentation genes active at each position along the anterior-posterior axis of the early embryo...
  47. ncbi Gene activities and segmental patterning in Drosophila: analysis of odd-skipped and pair-rule double mutants
    D E Coulter
    Department of Biology, Princeton University, New Jersey 08544
    Genes Dev 2:1812-23. 1988
    ..We conclude that the requirements of pattern elements for specific gene activities are not absolute, and propose mechanisms by which these genes interact to specify cell fates...
  48. pmc The Drosophila copia retrotransposon contains binding sites for transcriptional regulation by homeoproteins
    L Cavarec
    Unités de Physicochimie et Pharmacologie des Macromolécules Biologiques, CNRS U147 et INSERM U140, Institut Gustave Roussy, Villejuif, France
    Nucleic Acids Res 21:5041-9. 1993
    ..These homeodomain binding sites could be involved in the developmental regulation of the copia retrotransposon...
  49. ncbi Functional interactions between the pelle kinase, Toll receptor, and tube suggest a mechanism for activation of dorsal
    J L Norris
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Genes Dev 10:862-72. 1996
    ..Based on these and other results, we propose a model in which pll receives a signal from activated Toll and phosphorylates tube, which then participates directly in dl activation...
  50. ncbi Molecular evolution of the paired gene in Drosophila: cloning and characterization of the partial paired gene from Drosophila willistoni
    Y Matsuo
    Department of Mathematical and Natural Sciences, Faculty of Integrated Arts and Sciences, University of Tokushima, Japan
    Biochem Genet 34:415-20. 1996
    ..19 x 10(-9)/site/year, respectively. In contrast, the connecting region between the two boxes has been highly diverged and evolved very rapidly, 18.3 x 10(-9)/site/year, suggesting almost no functional constraint in the connecting region...
  51. ncbi Kinetic analysis of segmentation gene interactions in Drosophila embryos
    A Nasiadka
    Banting and Best Department of Medical Research, Department of Molecular and Medical Genetics, University of Toronto, Charles H Best Institute, Toronto, Ontario, M5G 1L6, Canada
    Development 126:1515-26. 1999
    ..In total, 11 putative Ftz target genes are analyzed, and the data provide a substantially revised view of Ftz roles and activities within the segmentation hierarchy...
  52. pmc Quantitative analysis of gene function in the Drosophila embryo
    W D Tracey
    Department of Biochemistry and Cell Biology and the Institute for Cell and Developmental Biology, State University of New York, Stony Brook, New York 11794 5215, USA
    Genetics 154:273-84. 2000
    ..The maternal GAL4 system will have applications both for the measurement of gene activity in reverse genetic experiments as well as for the identification of genetic factors that have quantitative effects on gene function in vivo...
  53. ncbi Pair-rule genes cooperate to activate en stripe 15 and refine its margins during germ band elongation in the D. melanogaster embryo
    D T Kuhn
    Department of Biology, University of Central Florida, 4000 Central Florida Boulevard, Orlando, FL 32816, USA
    Mech Dev 95:297-300. 2000
    ..for this study are the pair-rule genes even-skipped (eve), fushi tarazu (ftz), runt (run), hairy (h), paired (prd) and odd-skipped (odd), and the segment polarity gene (en)...
  54. ncbi Conserved signals and machinery for RNA transport in Drosophila oogenesis and embryogenesis
    S L Bullock
    Developmental Genetics Laboratory, Imperial Cancer Research Fund, London, UK
    Nature 414:611-6. 2001
    ..We propose that Egl and BicD are core components of a selective dynein motor complex that drives transcript localization in a variety of tissues...
  55. ncbi Playing by pair-rules?
    Gregory K Davis
    Department of Ecology and Evolutionary Biology, Princeton University, USA
    Bioessays 25:425-9. 2003
    ..Recent data of Dearden et al.1 and Henry et al.,2 however, hint that a pair-rule mechanism might play a role in the segmentation process of basal arthropods and vertebrates...
  56. pmc Drawing lines in the sand: even skipped et al. and parasegment boundaries
    James B Jaynes
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Dev Biol 269:609-22. 2004
    ..We present a new model of pair-rule gene function that explains the response of these boundaries to the relative levels of Eve and Fushi Tarazu...
  57. ncbi Analysis of the transcriptional activation domain of the Drosophila tango bHLH-PAS transcription factor
    Margaret J Sonnenfeld
    Department of Cellular and Molecular Medicine, University of Ottawa, Ontario, Canada K1H 8M5
    Dev Genes Evol 215:221-9. 2005
    ..These results together identify TGO's transactivation domain and establish its importance for proper target gene regulation and cellular specification...
  58. pmc Statistical lower bounds on protein copy number from fluorescence expression images
    Lee Zamparo
    Department of Computer Science and Software Engineering, Concordia University, Montreal, Quebec, Canada
    Bioinformatics 25:2670-6. 2009
    ..While this is satisfactory for many applications, for certain kinds of quantitative network modeling and analysis of expression noise, absolute measures of expression are necessary...
  59. doi Dynamic intracellular distribution of Notch during activation and asymmetric cell division revealed by functional fluorescent fusion proteins
    Koji Kawahashi
    RIKEN Center for Developmental Biology, Chuo Ku, Kobe, Japan
    Genes Cells 15:749-59. 2010
    ....
  60. doi The full-length transcripts and promoter analysis of intergenic microRNAs in Drosophila melanogaster
    Jinjun Qian
    Department of Entomology, College of Plant Protection, Nanjing Agricultural University Key Laboratory of Monitoring and Management of Crop Diseases and Pest Insects, Ministry of Agriculture, Nanjing 210095, China
    Genomics 97:294-303. 2011
    ..RNA interference of transcription factors Mad and Prd led to down-expression of bantam, miR-277 and miR-2b but not miR-276a, whereas RNAi of Dorsal had the opposite ..
  61. pmc Distinct molecular strategies for Hox-mediated limb suppression in Drosophila: from cooperativity to dispensability/antagonism in TALE partnership
    Nagraj Sambrani
    Centre National de la Recherche Scientifique, Aix Marseille Universite, Institut de Biologie du Developpement de Marseille Luminy, UMR 7288, Parc Scientifique de Luminy, Marseille, France
    PLoS Genet 9:e1003307. 2013
    ..Thus, changes in protein sequences not only provide the driving force for functional specialization of Hox paralogue proteins, but also provide means to perform common ancient functions in distinct ways...
  62. pmc Positional information, in bits
    Julien O Dubuis
    Joseph Henry Laboratories of Physics, Lewis Sigler Institute for Integrative Genomics, and Department of Molecular Biology, Princeton University, Princeton, NJ 08544
    Proc Natl Acad Sci U S A 110:16301-8. 2013
    ..We argue that this constancy is a signature of optimality in the transmission of information from primary morphogen inputs to the output of the gap gene network...
  63. pmc Inference of gene regulatory networks based on a universal minimum description length
    JOHN DOUGHERTY
    Institute of Signal Processing, Tampere University of Technology, Tampere, Finland
    EURASIP J Bioinform Syst Biol . 2008
    ..Finally, it is applied to time-series Drosophila gene expression measurements...
  64. doi Gene and epigene networks: two levels in organizing the hereditary system
    R N Tchuraev
    Institute of Biology, Ufa Research Center, Russian Academy of Sciences, 69 Prospect Oktyabrya, Ufa 450054, Russia
    J Theor Biol 259:659-69. 2009
    ..In addition, the experimental results are given on construction an artificial epigene...
  65. pmc Conserved catalytic and C-terminal regulatory domains of the C-terminal binding protein corepressor fine-tune the transcriptional response in development
    Yang W Zhang
    Department of Biochemistry and Molecular Biology, Michigan State University, 413 Biochemistry, East Lansing, MI 48824 1319, USA
    Mol Cell Biol 31:375-84. 2011
    ..Our results indicate that the structural and enzymatic features of CtBP, previously thought to be dispensable for overall transcriptional control, are critical for modulating this protein's activity in diverse developmental settings...
  66. pmc How to make stripes: deciphering the transition from non-periodic to periodic patterns in Drosophila segmentation
    Mark D Schroeder
    Laboratory of Developmental Neurogenetics, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Development 138:3067-78. 2011
    ..Overall, our study provides a greatly improved understanding of how periodic patterns are established in the Drosophila embryo...
  67. ncbi Selective nuclear transport of the Drosophila morphogen dorsal can be established by a signaling pathway involving the transmembrane protein Toll and protein kinase A
    J L Norris
    Department of Biological Sciences, Columbia University, New York, New York 10027
    Genes Dev 6:1654-67. 1992
    ..We discuss the significance of these results with respect both to Drosophila embryogenesis and to the regulation of the mammalian transcription factor NF-kappa B...
  68. ncbi Functional dissection of the paired segmentation gene in Drosophila embryos
    D Morrissey
    Department of Biology, Wesleyan University, Middletown, Connecticut 06459
    Genes Dev 5:1684-96. 1991
    ..It is hypothesized that the regions of overlap in expression of two genes, paired (prd) and even-skipped (eve), define the odd-numbered en expression stripes...
  69. ncbi (HX)n repeats: a pH-controlled protein-protein interaction motif of eukaryotic transcription factors?
    R Janknecht
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, Germany
    FEBS Lett 295:1-2. 1991
    ..g. HPHAHPHP in paired protein. Detailed molecular modelling and database searches lead to the suggestion that (HX)n repeats can mediate interaction between transcription factors in a pH-controlled fashion...
  70. ncbi Distribution and function of the lethal of scute gene product during early neurogenesis in Drosophila
    M D Martin-Bermudo
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Spain
    Development 113:445-54. 1991
    ..However, our study in l'sc mutants of the expression of fushi tarazu, engrailed, and even-skipped, used as markers of neuronal identity, has not provided evidence to support this hypothesis...
  71. ncbi The prospero gene encodes a divergent homeodomain protein that controls neuronal identity in Drosophila
    Q Chu-LaGraff
    Department of Cell and Structural Biology, University of Illinois, Urbana 61801
    Dev Suppl . 1991
    ..These data are consistent with a model in which pros controls neuroblast cell lineages by regulating gene expression...
  72. ncbi Synthetic oligonucleotides recreate Drosophila fushi tarazu zebra-stripe expression
    J Topol
    Division of Chemistry, California Institute of Technology, Pasadena 91125
    Genes Dev 5:855-67. 1991
    ..The reconstructed promoter system presented provides an effective means of studying molecular mechanisms governing spatially restricted transcription in the early embryo...
  73. ncbi What determines the specificity of action of Drosophila homeodomain proteins?
    S Hayashi
    National Institute of Genetics, Shizuoka ken, Japan
    Cell 63:883-94. 1990
  74. ncbi A new Drosophila homeo box gene is expressed in mesodermal precursor cells of distinct muscles during embryogenesis
    C Dohrmann
    Max Planck Institut fur Entwicklungsbiologie, Abteilung III Genetik, Tubingen, Germany
    Genes Dev 4:2098-111. 1990
    ..Here, the molecular analysis and expression pattern of one such gene, containing both a homeo box and a PRD repeat, is described...
  75. ncbi Spatial harmonics and pattern specification in early Drosophila development. Part I. Bifurcation sequences and gene expression
    B C Goodwin
    Department of Biology, Open University, Milton Keynes, U K
    J Theor Biol 144:303-19. 1990
    ..This model has implications for the general stability properties of evolving epigenetic systems...
  76. pmc Conservation of the paired domain in metazoans and its structure in three isolated human genes
    M Burri
    Department of Cell Biology, Biocenter of the University, Basel, Switzerland
    EMBO J 8:1183-90. 1989
    ..Possible functions of the paired domain are discussed in the light of a predicted helix-turn-helix structure in its carboxy-terminal portion...
  77. ncbi Megaprimer method for in vitro mutagenesis using parallel templates
    M Upender
    Wesleyan University, Middletown, CT 06459
    Biotechniques 18:29-30, 32. 1995
  78. ncbi On the functional overlap between two Drosophila POU homeo domain genes and the cell fate specification of a CNS neural precursor
    S L Yeo
    Institute of Molecular and Cell Biology, National University of Singapore
    Genes Dev 9:1223-36. 1995
    ..Hence, the failure of the POU mutants to produce mature RP2 neurons is not attributable to a block in GMC4-2a cell division per se but, rather, because the GMC4-2a cells fail to acquire their correct cellular identity...
  79. ncbi Evolution of distinct developmental functions of three Drosophila genes by acquisition of different cis-regulatory regions
    X Li
    Institute for Molecular Biology II, University of Zurich, Switzerland
    Nature 367:83-7. 1994
    ..The three paired-box and homeobox genes paired (prd), gooseberry (gsb) and gooseberry neuro (gsbn) have distinct developmental functions in Drosophila embryogenesis...
  80. ncbi Genetic factors controlling the expression of the abdominal-A gene of Drosophila within its domain
    A Macias
    Centro de Biologia Molecular, Universidad Autonoma de Madrid CSIC, Spain
    Mech Dev 46:15-25. 1994
    ..The genes fushi tarazu, and especially engrailed, appear to act as transcriptional activating factors of abd-A...
  81. pmc Synergistic activation of transcription is mediated by the N-terminal domain of Drosophila fushi tarazu homeoprotein and can occur without DNA binding by the protein
    J Ananthan
    Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Florida 33101 6129
    Mol Cell Biol 13:1599-609. 1993
    ..We examined the synergistic activation of an engrailed-derived promoter by the pair-rule proteins paired (PRD) and fushi tarazu (FTZ)...
  82. pmc Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties
    Z Kozmik
    Research Institute of Molecular Pathology, Vienna, Austria
    Mol Cell Biol 13:6024-35. 1993
    ..Hence, alternative splicing of Pax-8 gene transcripts not only generates six different Pax-8 variants but is also temporally and spatially regulated during early mouse development...
  83. ncbi Patterning of the Drosophila embryo by a homeodomain-deleted Ftz polypeptide
    J W Copeland
    Banting and Best Department of Medical Research, University of Toronto, Charles H Best Institute, Ontario, Canada
    Nature 379:162-5. 1996
    ..A likely candidate is the pair-rule protein Paired (Prd). Ftz delta HD bound directly to Prd in vitro and required Prd to repress wingless in vivo...
  84. ncbi Drosophila differentiation genes instrumental in tumor suppression
    E Gateff
    Institut fur Genetik, Johannes Gutenberg Universitat, Mainz, Germany
    Int J Dev Biol 40:149-56. 1996
    ....
  85. ncbi Evolution of functional diversification of the paired box (Pax) DNA-binding domains
    K A Balczarek
    Department of Biology, Pennsylvania State University, University Park 16802, USA
    Mol Biol Evol 14:829-42. 1997
    ..Implications of such fixed amino acid differences in potentially generating sequence recognition specificities are discussed in the context of some recent experimental findings...
  86. ncbi Differential accumulation of DPTP61F alternative transcripts: regulation of a protein tyrosine phosphatase by segmentation genes
    Z Ursuliak
    Institute of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada
    Mech Dev 65:19-30. 1997
    ..The segmental modulation of DPTP61Fm transcript accumulation in the A/P axis of the germband is regulated by the pair-rule genes, and the intrasegmental pattern of transcript accumulation is regulated by the segment polarity genes...
  87. pmc The Pax2 homolog sparkling is required for development of cone and pigment cells in the Drosophila eye
    W Fu
    Institute for Molecular Biology, Division II, University of Zurich, Switzerland
    Genes Dev 11:2066-78. 1997
    ..Spa expression is further required for activation of cut in cone cells and of the Bar locus in primary pigment cells. We suggest close functional analogies between Spa and Pax2 in the development of the insect and vertebrate eye...
  88. ncbi Plasticity of Drosophila paired function
    Y Lan
    Department of Biology, Wesleyan University, Middletown, Connecticut 06459, USA
    Dev Genet 23:45-55. 1998
    The Drosophila Paired (Prd) transcription factor has homeodomain (HD) and paired domain (PD) DNA-binding activities required for in vivo function...
  89. ncbi Evolution of homeobox genes: Q50 Paired-like genes founded the Paired class
    B Galliot
    Department of Zoology and Animal Biology, University of Geneva, Geneva, Switzerland
    Dev Genes Evol 209:186-97. 1999
    ..Consequently, most Pax genes arose from a Paired-like ancestor, via fusion of a Paired-like homebox gene with a gene encoding only a paired domain; the Cnidaria appear to contain genes representing the 'before' and 'after' fusion events...
  90. ncbi Drosophila: flying high in Zürich
    A S Wilkins
    BioEssays Editorial Office, 10 11 Tredgold Lane, Napier St, Cambridge CB1 1HN, UK
    Bioessays 22:305-7. 2000
  91. ncbi Pairing partners
    S Greaves
    Nat Cell Biol 2:E216. 2000
  92. ncbi Evolution of transcription factor function
    Cheryl C Hsia
    Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, California 92093, USA
    Curr Opin Genet Dev 13:199-206. 2003
    ..Interestingly, recent studies provide evidence that changes in transcription factor protein sequence can affect the regulation of only a subset of target genes, even in the same cells of a developing animal...
  93. ncbi Ftz modulates Runt-dependent activation and repression of segment-polarity gene transcription
    Deborah Swantek
    Department of Biochemistry and Cell Biology and the Center for Developmental Genetics, State University of New York at Stony Brook, Stony Brook, NY 11794 5140, USA
    Development 131:2281-90. 2004
    ..The unique and simple rules for slp1 regulation make this an attractive target for dissecting the molecular mechanisms of Runt-dependent regulation...
  94. pmc An eh1-like motif in odd-skipped mediates recruitment of Groucho and repression in vivo
    Robert E Goldstein
    Department of Biochemistry, Faculty of Medicine, The Hebrew University, Jerusalem, Israel
    Mol Cell Biol 25:10711-20. 2005
    ..Our data suggest that phosphorylation of these phosphomeric residues, if it occurs, will down-regulate Groucho binding and therefore repression, providing a mechanism for posttranslational control of Groucho-mediated repression...
  95. pmc Repression and loss of gene expression outpaces activation and gain in recently duplicated fly genes
    Todd H Oakley
    Ecology Evolution and Marine Biology, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 103:11637-41. 2006
    ..The trend is important because repression of gene expression is a hypothesized mechanism for the origin of evolutionarily novel morphologies through specialization...
  96. pmc The origins of the Drosophila leg revealed by the cis-regulatory architecture of the Distalless gene
    Daniel J Mckay
    Department of Biochemistry and Molecular Biophysics, Integrated Program in Cellular, Molecular, Structural and Genetic Studies, Columbia University, 701 W 168th Street, HHSC 1104, New York, NY 10032, USA
    Development 136:61-71. 2009
    ..Together, these findings provide a complete and high-resolution fate map of the Drosophila appendage primordia, linking the primary domains to specific cis-regulatory elements in Dll...
  97. pmc Anterior-posterior positional information in the absence of a strong Bicoid gradient
    Amanda Ochoa-Espinosa
    Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Proc Natl Acad Sci U S A 106:3823-8. 2009
    ....
  98. ncbi The homeodomain: a new face for the helix-turn-helix?
    J Treisman
    Howard Hughes Medical Institute, Rockefeller University, New York
    Bioessays 14:145-50. 1992
    ..We propose that this intrinsic complexity of the HD, as well as its frequent association with other DNA binding domains, explains the functional specificity achieved by genes encoding highly related HDs...
  99. ncbi The homeobox in perspective
    W J Gehring
    Biozentrum, University of Basel, Switzerland
    Trends Biochem Sci 17:277-80. 1992
    ..Their mechanism of action can now be studied at the molecular level and their occurrence seems to be much more universal than originally anticipated...
  100. ncbi Human and Drosophila homeodomain proteins that enhance the DNA-binding activity of serum response factor
    D A Grueneberg
    Cold Spring Harbor Laboratory, NY 11724
    Science 257:1089-95. 1992
    ....
  101. ncbi Cloning of the Drosophila prospero gene and its expression in ganglion mother cells
    F Matsuzaki
    Division of Molecular Genetics, National Institute of Neuroscience, NCNP, Tokyo, Japan
    Biochem Biophys Res Commun 182:1326-32. 1992
    ..Our results provoke that in neuronal cell differentiation ganglion mother cells might play a pivotal role associating with the pros function...

Patents1

  1. Recombinant fowlpox virus with intact FPV-tk-gene
    Patent Number: EP0538496-A1; Date:1993-04-28