ple

Summary

Gene Symbol: ple
Description: pale
Alias: CG10118, DH65B, DTH, Dmel\CG10118, Pale, Ple, VII, dTH1, dTH65B, pale/ple, CG10118 gene product from transcript CG10118-RC, CG10118-PA, CG10118-PB, CG10118-PC, Tyrosine-3-hydroxylase, XBB70 group VII, drosophila tyrosine hydroxylase, ple-PA, ple-PB, ple-PC, tyrosine hydrodroxylase, tyrosine hydroxylase, tyrosine-hydroxylase, tyrosone hydroxylase
Species: fruit fly

Top Publications

  1. ncbi How the fruit fly changed (some of) its spots
    P M O'Grady
    Division of Invertebrates, American Museum of Natural History, New York 10024, USA
    Curr Biol 10:R75-7. 2000
  2. ncbi Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila
    Yufeng Yang
    Laboratory of Developmental Neurobiology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 37:911-24. 2003
  3. ncbi Mapping of serotonin, dopamine, and histamine in relation to different clock neurons in the brain of Drosophila
    Yasutaka Hamasaka
    Department of Zoology, Stockholm University, SE 10691, Sweden
    J Comp Neurol 494:314-30. 2006
  4. pmc Behavioral consequences of dopamine deficiency in the Drosophila central nervous system
    Thomas Riemensperger
    Genetics and Physiopathology of Neurotransmission, Laboratoire de Neurobiologie, Centre National de la Recherche Scientifique, Ecole Supérieure de Physique et de Chimie Industrielles ParisTech, 75005 Paris, France
    Proc Natl Acad Sci U S A 108:834-9. 2011
  5. ncbi Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
    Jeehye Park
    Nature 441:1157-61. 2006
  6. pmc A pair of dopamine neurons target the D1-like dopamine receptor DopR in the central complex to promote ethanol-stimulated locomotion in Drosophila
    Eric C Kong
    Ernest Gallo Clinic and Research Center, Emeryville, California, United States of America
    PLoS ONE 5:e9954. 2010
  7. ncbi Interaction of genetic and environmental factors in a Drosophila parkinsonism model
    Anathbandhu Chaudhuri
    Department of Biological Sciences, University of Alabama, Tuscaloosa, Alabama 35487 0344, USA
    J Neurosci 27:2457-67. 2007
  8. ncbi Dopamine-mushroom body circuit regulates saliency-based decision-making in Drosophila
    Ke Zhang
    Institute of Neuroscience, Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences CAS, 320 Yueyang Road, Shanghai 200031, China
    Science 316:1901-4. 2007
  9. pmc Eight different types of dopaminergic neurons innervate the Drosophila mushroom body neuropil: anatomical and physiological heterogeneity
    Zhengmei Mao
    Department of Molecular and Cellular Biology, Baylor College of Medicine Houston, TX, USA
    Front Neural Circuits 3:5. 2009
  10. ncbi Multiple roles for dopamine in Drosophila development
    W S Neckameyer
    Department of Pharmacological and Physiological Science, St Louis University School of Medicine, Missouri 63108, USA
    Dev Biol 176:209-19. 1996

Scientific Experts

Detail Information

Publications103 found, 100 shown here

  1. ncbi How the fruit fly changed (some of) its spots
    P M O'Grady
    Division of Invertebrates, American Museum of Natural History, New York 10024, USA
    Curr Biol 10:R75-7. 2000
    ..While several genes have been shown to play a role in melanization, changes in a single gene - the one encoding tyrosine hydroxylase - are sufficient to generate novel pigmentation patterns.
  2. ncbi Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila
    Yufeng Yang
    Laboratory of Developmental Neurobiology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 37:911-24. 2003
    ..Our study implicates Parkin as a central player in the molecular pathway of Parkinson's disease (PD) and suggests that manipulating Parkin expression may provide a novel avenue of PD therapy...
  3. ncbi Mapping of serotonin, dopamine, and histamine in relation to different clock neurons in the brain of Drosophila
    Yasutaka Hamasaka
    Department of Zoology, Stockholm University, SE 10691, Sweden
    J Comp Neurol 494:314-30. 2006
    ..protein (GFP) expression, combined with immunocytochemistry with antisera against serotonin, histamine, and tyrosine hydroxylase (for dopamine)...
  4. pmc Behavioral consequences of dopamine deficiency in the Drosophila central nervous system
    Thomas Riemensperger
    Genetics and Physiopathology of Neurotransmission, Laboratoire de Neurobiologie, Centre National de la Recherche Scientifique, Ecole Supérieure de Physique et de Chimie Industrielles ParisTech, 75005 Paris, France
    Proc Natl Acad Sci U S A 108:834-9. 2011
    ..To learn more about the function of neural DA in Drosophila, we generated mutant flies that lack tyrosine hydroxylase, and thus DA biosynthesis, selectively in the nervous system...
  5. ncbi Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
    Jeehye Park
    Nature 441:1157-61. 2006
    ..Taken together, our genetic evidence clearly establishes that Parkin and PINK1 act in a common pathway in maintaining mitochondrial integrity and function in both muscles and dopaminergic neurons...
  6. pmc A pair of dopamine neurons target the D1-like dopamine receptor DopR in the central complex to promote ethanol-stimulated locomotion in Drosophila
    Eric C Kong
    Ernest Gallo Clinic and Research Center, Emeryville, California, United States of America
    PLoS ONE 5:e9954. 2010
    ..These data tie the activity of defined dopamine neurons to D1-like DopR-expressing neurons to form a neural circuit that governs acute responding to ethanol...
  7. ncbi Interaction of genetic and environmental factors in a Drosophila parkinsonism model
    Anathbandhu Chaudhuri
    Department of Biological Sciences, University of Alabama, Tuscaloosa, Alabama 35487 0344, USA
    J Neurosci 27:2457-67. 2007
    ....
  8. ncbi Dopamine-mushroom body circuit regulates saliency-based decision-making in Drosophila
    Ke Zhang
    Institute of Neuroscience, Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences CAS, 320 Yueyang Road, Shanghai 200031, China
    Science 316:1901-4. 2007
    ..Immunohistological analysis showed that mushroom bodies are densely innervated by dopaminergic axons. Thus, the circuit from the dopamine system to mushroom bodies is crucial for choice behavior in Drosophila...
  9. pmc Eight different types of dopaminergic neurons innervate the Drosophila mushroom body neuropil: anatomical and physiological heterogeneity
    Zhengmei Mao
    Department of Molecular and Cellular Biology, Baylor College of Medicine Houston, TX, USA
    Front Neural Circuits 3:5. 2009
    We examined tyrosine hydroxylase (TH-GAL4) expression and anti-TH immunoreactivity in the Drosophila protocerebrum and characterized single cell clones of the TH-GAL4 neurons...
  10. ncbi Multiple roles for dopamine in Drosophila development
    W S Neckameyer
    Department of Pharmacological and Physiological Science, St Louis University School of Medicine, Missouri 63108, USA
    Dev Biol 176:209-19. 1996
    Manipulation of dopamine levels by inhibition of tyrosine hydroxylase activity was accomplished in Drosophila melanogaster larval instars by feeding enzyme inhibitors for a 24-hr period...
  11. ncbi Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress
    Fiona M Menzies
    Neurogenetics Branch MSC 3705, Building 35, Room 2A 1002 NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
    Curr Biol 15:1578-82. 2005
    ..These results suggest that Drosophila homologs of DJ-1 play critical roles in the survival of dopaminergic neurons and response to oxidative stress...
  12. pmc A neural circuit mechanism integrating motivational state with memory expression in Drosophila
    Michael J Krashes
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Cell 139:416-27. 2009
    ..Therefore, dNPF and dopamine provide a motivational switch in the mushroom body that controls the output of appetitive memory...
  13. ncbi Differential regulation of Drosophila tyrosine hydroxylase isoforms by dopamine binding and cAMP-dependent phosphorylation
    A Vie
    Laboratoire de Neurobiologie Cellulaire et Fonctionnelle, CNRS, 13009 Marseille, France
    J Biol Chem 274:16788-95. 1999
    b>Tyrosine hydroxylase (TH) catalyzes the first step in dopamine biosynthesis in Drosophila as in vertebrates...
  14. pmc Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling
    Yufeng Yang
    Department of Pathology, Stanford University School of Medicine, and Geriatric Research, Education and Clinical Center Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 102:13670-5. 2005
    ..Manipulation of PI3K/Akt signaling may therefore offer therapeutic benefits for the treatment of PD...
  15. ncbi Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease
    Pavan K Auluck
    Department of Neuroscience, University of Pennsylvania and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 295:865-8. 2002
    ..Furthermore, Lewy bodies in human postmortem tissue immunostained for molecular chaperones, also suggesting that chaperones may play a role in Parkinson's disease progression...
  16. ncbi Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila
    Pavan K Auluck
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 280:2873-8. 2005
    ..These studies indicate that compounds that modulate the stress response are a promising approach to treat Parkinson's disease...
  17. ncbi Chronic exposure to rotenone models sporadic Parkinson's disease in Drosophila melanogaster
    Hélène Coulom
    Laboratoire de Genetique et Physiologie du Developpement, Centre National de la Recherche Scientifique, UniversitédelaMéditerranée, Developmental Biology Institute of Marseille, Campus de Luminy, F 13288 Marseille Cedex 9, France
    J Neurosci 24:10993-8. 2004
    ..Therefore, chronic exposure to pesticides recapitulates key aspects of PD in Drosophila and provides a new in vivo model for studying the mechanisms of dopaminergic neurodegeneration...
  18. ncbi A single locus encodes both phenylalanine hydroxylase and tryptophan hydroxylase activities in Drosophila
    W S Neckameyer
    Department of Biology, Brandeis University, Waltham, Massachusetts 02254
    J Biol Chem 267:4199-206. 1992
    ..We propose that there are only two aromatic amino acid hydroxylase genes in Drosophila: one encoding tyrosine hydroxylase, DTH, and DTPH, a gene encoding both tryptophan and phenylalanine hydroxylase activities.
  19. ncbi Isolation and characterization of the gene for Drosophila tyrosine hydroxylase
    W S Neckameyer
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139
    Neuron 2:1167-75. 1989
    A Drosophila cDNA homologous to a rat tyrosine hydroxylase (TH) probe has been isolated and sequenced. The deduced amino acid sequence predicts a 57,861 dalton protein with almost 50% identity with rat TH...
  20. ncbi Genetic dissection of dopamine and serotonin synthesis in the nervous system of Drosophila melanogaster
    V Budnik
    Biophysics Program, Brandeis University, Waltham, MA 02254
    J Neurogenet 4:309-14. 1987
    ..We suggest that pale is either the tyrosine hydroxylase structural gene, or a gene controlling tyrosine hydroxylase activity in Drosophila...
  21. ncbi drifter, a Drosophila POU-domain transcription factor, is required for correct differentiation and migration of tracheal cells and midline glia
    M G Anderson
    Department of Physiology and Biophysics, University of Iowa, College of Medicine, Iowa City 52242
    Genes Dev 9:123-37. 1995
    ....
  22. ncbi A novel and major isoform of tyrosine hydroxylase in Drosophila is generated by alternative RNA processing
    S Birman
    Department of Biology, University of Virginia, Charlottesville 22903
    J Biol Chem 269:26559-67. 1994
    We report that two isoforms of Drosophila tyrosine hydroxylase protein are encoded via alternatively spliced exons...
  23. ncbi Drosophila tyrosine hydroxylase is encoded by the pale locus
    W S Neckameyer
    Department of Biology, Brandeis University, Waltham, MA 02254
    J Neurogenet 8:189-99. 1993
    We have reintroduced an 8 kb genomic fragment from the Drosophila tyrosine hydroxylase (DTH) locus into the genome of mutant pale (ple) flies. ple was first recovered as a recessive embryonic lethal by Jurgens et al...
  24. pmc Dopamine and mushroom bodies in Drosophila: experience-dependent and -independent aspects of sexual behavior
    W S Neckameyer
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, Missouri 63104, USA
    Learn Mem 5:157-65. 1998
    ..One kilobase of 5' upstream information from the Drosophila tyrosine hydroxylase (DTH) gene, when fused to the Escherichia coli beta-galactosidase reporter and transduced into the ..
  25. ncbi Drosophila wing melanin patterns form by vein-dependent elaboration of enzymatic prepatterns
    J R True
    Laboratory of Molecular Biology, Howard Hughes Medical Institute, University of Wisconsin, Madison 53706, USA
    Curr Biol 9:1382-91. 1999
    ..We have taken a genetic approach to elucidate the developmental mechanisms underlying melanin pattern formation in various drosophilids...
  26. ncbi A Drosophila model of Parkinson's disease
    M B Feany
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 404:394-8. 2000
    ..Our Drosophila model thus recapitulates the essential features of the human disorder, and makes possible a powerful genetic approach to Parkinson's disease...
  27. ncbi Dopamine and senescence in Drosophila melanogaster
    W S Neckameyer
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Blvd, St Louis, MO 63104, USA
    Neurobiol Aging 21:145-52. 2000
    ..Immunocytochemical analysis of adult brains using an antibody raised against Drosophila tyrosine hydroxylase to visualize catecholaminergic cell bodies revealed increased degeneration of the cell bodies with ..
  28. ncbi Functional interactions between GTP cyclohydrolase I and tyrosine hydroxylase in Drosophila
    S Krishnakumar
    Department of Biological Sciences and Coalition for BioMolecular Products, Box 870344, University of Alabama, Tuscaloosa, AL 35487, USA
    J Neurogenet 14:1-23. 2000
    b>Tyrosine hydroxylase requires the regulatory cofactor, tetrahydrobiopterin, for catecholamine biosynthesis...
  29. ncbi Dopamine and sensory tissue development in Drosophila melanogaster
    W Neckameyer
    Department of Pharmacological and Physiological Science, St Louis University School of Medicine, St Louis, Missouri 63108, USA
    J Neurobiol 47:280-94. 2001
    ..apparatus, transgenic lines were generated containing 1 or 4 kb of 5' upstream sequences from the Drosophila tyrosine hydroxylase gene (DTH) fused to the E. coli beta-galactosidase reporter...
  30. ncbi Effects of tyrosine hydroxylase mutants on locomotor activity in Drosophila: a study in functional genomics
    Robert G Pendleton
    Department of Biology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Behav Genet 32:89-94. 2002
    The brain of the adult fruit fly, Drosophila melanogaster, contains tyrosine hydroxylase, the rate-limiting enzyme required for catecholamine biosynthesis, as well as dopa decarboxylase...
  31. ncbi Targeted gene expression in Drosophila dopaminergic cells using regulatory sequences from tyrosine hydroxylase
    Florence Friggi-Grelin
    Laboratoire de Genetique et Physiologie du Developpement, CNRS Université de la Méditerranée, Developmental Biology Institute of Marseille, Campus de Luminy, Case 907, F 13288 Marseille Cedex 9, France
    J Neurobiol 54:618-27. 2003
    ..In Drosophila as in vertebrates, the rate-limiting step in DA biosynthesis is catalyzed by the enzyme tyrosine hydroxylase (TH)...
  32. ncbi Tissue-specific developmental requirements of Drosophila tyrosine hydroxylase isoforms
    Florence Friggi-Grelin
    Laboratoire de Genetique et Physiologie du Developpement, Developmental Biology Institute of Marseille, Campus de Luminy, F 13288 Marseille Cedex 9, France
    Genesis 35:260-9. 2003
    b>Drosophila tyrosine hydroxylase (DTH) is a key enzyme in dopamine (DA) biosynthesis, which is expressed in neural and hypodermal DA-synthesizing cells...
  33. ncbi Evolution in black and white: genetic control of pigment patterns in Drosophila
    Patricia J Wittkopp
    Molecular Biology and Genetics, 227 Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
    Trends Genet 19:495-504. 2003
  34. ncbi Female-specific regulation of cuticular hydrocarbon biosynthesis by dopamine in Drosophila melanogaster
    Charlotte Marican
    Laboratoire NAMC UMR 8620, Universite Paris Sud, Neurobiologie et Apprentissage de la Mémoire et de la Communication, rue Georges Clemenceau, 91405 Orsay, France
    Insect Biochem Mol Biol 34:823-30. 2004
    ..at restrictive temperature, and rescued by dopamine ingestion or by pale mutants partially rescued by a tyrosine hydroxylase construction), pharmacological treatments (tyrosine hydroxylase inhibitors) and topical application on ..
  35. pmc Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease
    Alexander J Whitworth
    Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 102:8024-9. 2005
    ..Moreover, these findings identify a potential therapeutic approach in treating PD...
  36. pmc Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila
    Guang Ho Cha
    National Creative Research Initiatives Center for Cell Growth Regulation, and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Kusong Dong, Yusong gu, Taejon 305 701, Korea
    Proc Natl Acad Sci U S A 102:10345-50. 2005
    ..Drosophila parkin loss-of-function mutants, which exhibit shrinkage of dopaminergic neurons with decreased tyrosine hydroxylase level and impaired locomotion...
  37. ncbi Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease
    Marc Meulener
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Curr Biol 15:1572-7. 2005
    ..Study of these flies will provide insight into the critical interplay of genetics and environment in PD...
  38. ncbi Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction
    Jeehye Park
    National Creative Research Initiatives Center for Cell Growth Regulation, Korea Advanced Institute of Science and Technology, 373 1 Kusong Dong, Yusong, Taejon 305 701, Korea
    Gene 361:133-9. 2005
    ..Moreover, we found that Drosophila DJ-1 is prominently localized in mitochondria, suggesting that DJ-1 functions as a protector against oxidative stress in mitochondria...
  39. ncbi Transcriptional regulation of neuropeptide and peptide hormone expression by the Drosophila dimmed and cryptocephal genes
    Sebastien A Gauthier
    Department of Zoology, Stephenson Research and Technology Center, University of Oklahoma, Norman, OK 73019, USA
    J Exp Biol 209:1803-15. 2006
    ..These results suggest that convergence between ATF-related signaling and an important intracellular steroid response pathway may contribute to the neuroendocrine regulation of insect molting...
  40. pmc Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin
    Yufeng Yang
    Department of Pathology and Geriatric Research, Education and Clinical Center Veterans Affairs Palo Alto Health Care System, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 103:10793-8. 2006
    ..Together, these results implicate Pink1 and Parkin in a common pathway that regulates mitochondrial physiology and cell survival in Drosophila...
  41. pmc Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila
    Danling Wang
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:13520-5. 2006
    ....
  42. ncbi Loss of spastic paraplegia gene atlastin induces age-dependent death of dopaminergic neurons in Drosophila
    Youngseok Lee
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Guseong dong, Yuseong Gu, Daejeon 305 701, Republic of Korea
    Neurobiol Aging 29:84-94. 2008
    ..Our data raised the possibility that one of the causes of HSP disease symptoms in human patients with alt mutations is malfunction or degeneration of dopaminergic neurons...
  43. ncbi Locomotor activity is regulated by D2-like receptors in Drosophila: an anatomic and functional analysis
    Isabelle Draper
    Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, Massachusetts, USA
    Dev Neurobiol 67:378-93. 2007
    ..These results suggest Drosophila as a useful system for future studies aimed at identifying modifiers of dopaminergic signaling/locomotor function...
  44. ncbi A neuropeptide hormone cascade controls the precise onset of post-eclosion cuticular tanning in Drosophila melanogaster
    Monica M Davis
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada
    Development 134:4395-404. 2007
    ..Together, two enzymes, tyrosine hydroxylase (TH, encoded by ple) and dopa decarboxylase (DDC, encoded by Ddc), produce the dopamine that is required ..
  45. doi Intrinsic neurons of Drosophila mushroom bodies express short neuropeptide F: relations to extrinsic neurons expressing different neurotransmitters
    Helena A D Johard
    Department of Zoology, Stockholm University, S 10691 Stockholm, Sweden
    J Comp Neurol 507:1479-96. 2008
    ..However, it is likely that the Kenyon cells utilize an additional neurotransmitter, yet to be identified, and that the neuropeptides described here may represent cotransmitters...
  46. pmc Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons
    Danling Wang
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Mol Neurodegener 3:3. 2008
    ..Increased LRRK2 kinase activity plays a critical role in pathogenic LRRK2 mutant-induced neurodegeneration in vitro. Little is known about the physiological function of LRRK2...
  47. pmc A Drosophila model for LRRK2-linked parkinsonism
    Zhaohui Liu
    Department of Psychiatry, Division of Neurobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 105:2693-8. 2008
    ..Treatment with l-DOPA improved mutant LRRK2-induced locomotor impairment but did not prevent the loss of tyrosine hydroxylase-positive neurons...
  48. pmc Neuroarchitecture of aminergic systems in the larval ventral ganglion of Drosophila melanogaster
    Matthias Vömel
    Emmy Noether Neuropeptide Group, Animal Physiology, Department of Biology, Philipps University Marburg, Marburg, Germany
    PLoS ONE 3:e1848. 2008
    ..With tyrosine hydroxylase- (TH) or tyrosine decarboxylase 2 (TDC2)-specific gal4-drivers, we also analyzed the distribution of ..
  49. doi Neuronal assemblies of the Drosophila mushroom body
    Nobuaki K Tanaka
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113 0032, Japan
    J Comp Neurol 508:711-55. 2008
    ..Structural differences between lobes are also discussed...
  50. pmc Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
    Yuzuru Imai
    Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    EMBO J 27:2432-43. 2008
    ..Our results suggest that chronic inactivation of 4E-BP by LRRK2 with pathogenic mutations deregulates protein translation, eventually resulting in age-dependent loss of DA neurons...
  51. pmc In vivo electrochemical measurements of exogenously applied dopamine in Drosophila melanogaster
    Monique A Makos
    Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Anal Chem 81:1848-54. 2009
    ..These data suggest that factors that affect neuronal activity via ion channels such as TTX also influence the function of the dopamine transporter in Drosophila...
  52. pmc The role of dopamine in Drosophila larval classical olfactory conditioning
    Mareike Selcho
    Department of Biology, University of Fribourg, Fribourg, Switzerland
    PLoS ONE 4:e5897. 2009
    ..Future studies of the dopaminergic system need to take into account such cellular dissociations in function in order to be meaningful...
  53. pmc Persistent short-term memory defects following sleep deprivation in a drosophila model of Parkinson disease
    Laurent Seugnet
    Washington University School of Medicine, St Louis, MO 63110, USA
    Sleep 32:984-92. 2009
    ..Thus we investigated the long-term consequences of sleep deprivation on shortterm memory using a Drosophila model of Parkinson disease...
  54. pmc Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila
    Chee Hoe Ng
    National Neuroscience Institute, Singapore
    J Neurosci 29:11257-62. 2009
    ..Together, our results suggest a potential link between LRRK2, parkin, and mitochondria in the pathogenesis of LRRK2-related parkinsonism...
  55. pmc Writing memories with light-addressable reinforcement circuitry
    Adam Claridge-Chang
    Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, UK
    Cell 139:405-15. 2009
    ..The delineation of core reinforcement circuitry is an essential first step in dissecting the neural mechanisms that compute and represent valuations, store associations, and guide actions...
  56. pmc Roles of dopamine in circadian rhythmicity and extreme light sensitivity of circadian entrainment
    Jay Hirsh
    Department of Biology, University of Virginia, Charlottesville, VA 22903, USA
    Curr Biol 20:209-14. 2010
    ..We use GAL4;UAS-mediated rescue of tyrosine hydroxylase (DTH) mutant (ple) flies to study the roles of dopamine in these processes...
  57. doi Extended lifespan of Drosophila parkin mutants through sequestration of redox-active metals and enhancement of anti-oxidative pathways
    Nidhi Saini
    Institute for Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, CH 8051 Zürich, Switzerland
    Neurobiol Dis 40:82-92. 2010
    ..They also corroborate that oxidative stress, perhaps as a consequence of mitochondrial dysfunction, is a major determinant of morbidity in parkin mutant flies...
  58. doi Cellular organization of the neural circuit that drives Drosophila courtship behavior
    Jai Y Yu
    Research Institute of Molecular Pathology, Vienna, Austria
    Curr Biol 20:1602-14. 2010
    ....
  59. doi LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ß
    Chin Hsien Lin
    Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
    J Neurosci 30:13138-49. 2010
    ..G2019S increases the recruitment of autoactivated Sgg, thus inducing hyperphosphorylation and mislocalization of tau with resultant dendrite degeneration...
  60. pmc The dopaminergic system in the aging brain of Drosophila
    Katherine E White
    Department of Neuroscience, Institute of Psychiatry, Medical Research Council Centre for Neurodegeneration Research, King s College London London, UK
    Front Neurosci 4:205. 2010
    ..Taken together, our data establish baseline parameters in Drosophila for the study of Parkinson's disease as well as other disorders affecting DA neurons and movement control...
  61. doi Chemical neuroanatomy of the Drosophila central complex: distribution of multiple neuropeptides in relation to neurotransmitters
    Lily Kahsai
    Department of Zoology, Stockholm University, Stockholm, Sweden
    J Comp Neurol 519:290-315. 2011
    ....
  62. pmc Dopamine signalling in mushroom bodies regulates temperature-preference behaviour in Drosophila
    Sunhoe Bang
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Taejon, Korea
    PLoS Genet 7:e1001346. 2011
    ..The current findings will provide important bases to understand the logic of thermosensation and temperature preference decision in Drosophila...
  63. doi Mushroom body efferent neurons responsible for aversive olfactory memory retrieval in Drosophila
    Julien Séjourné
    Genes and Dynamics of Memory Systems, Neurobiology Unit, CNRS, Ecole Superieure de Physique et de Chimie Industrielles, Paris, France
    Nat Neurosci 14:903-10. 2011
    ..As the lateral horn has been implicated in innate responses to repellent odorants, we propose that MB-V2 neurons recruit the olfactory pathway involved in innate odor avoidance during memory retrieval...
  64. pmc Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models
    Zhaohui Liu
    Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, Baltimore, MD 21201, USA
    Hum Mol Genet 20:3933-42. 2011
    ..These findings indicate that increased kinase activity of LRRK2 is neurotoxic and that inhibition of LRRK2 activity can have a disease-modifying effect. This suggests that inhibition of LRRK2 holds promise as a treatment for PD...
  65. pmc Serotonin-mushroom body circuit modulating the formation of anesthesia-resistant memory in Drosophila
    Pei Tseng Lee
    Department of Life Science, National Tsing Hua University, Hsinchu 30013, Taiwan
    Proc Natl Acad Sci U S A 108:13794-9. 2011
    ..Thus, in addition to the Amnesiac peptide required for anesthesia-sensitive memory formation, the two DPM neurons also release 5HT acting on MB neurons for ARM formation...
  66. pmc Essential role of Duox in stabilization of Drosophila wing
    Nguyen Thi Tu Anh
    Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto 606 8585, Japan
    J Biol Chem 286:33244-51. 2011
    ..Respective knockdown of tyrosine hydroxylase or dopa-decarboxylase showed paler wing blades in the posterior compartment similar to the phenotype of ..
  67. pmc Catecholamines up integrates dopamine synthesis and synaptic trafficking
    Zhe Wang
    Department of Biological Sciences, University of Alabama, Tuscaloosa, Alabama 35487, USA
    J Neurochem 119:1294-305. 2011
    ..Catsup, with GTP cyclohydrolase rate-limiting enzyme for tetrahydrobiopterin (BH(4)) biosynthesis and tyrosine hydroxylase, rate-limiting enzyme for dopamine biosynthesis, which requires BH(4) as a cofactor...
  68. pmc Orthodenticle is necessary for survival of a cluster of clonally related dopaminergic neurons in the Drosophila larval and adult brain
    Jorge Blanco
    Institute of Medical Biology, 8A Biomedical Grove, Singapore 138648
    Neural Dev 6:34. 2011
    ....
  69. pmc Dtorsin, the Drosophila ortholog of the early-onset dystonia TOR1A (DYT1), plays a novel role in dopamine metabolism
    Noriko Wakabayashi-Ito
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 6:e26183. 2011
    ..This dtorsin mutant line will be valuable for understanding this relationship and potentially other novel torsin functions that could play a role in human dystonia...
  70. pmc Three dopamine pathways induce aversive odor memories with different stability
    Yoshinori Aso
    Max Planck Institut fur Neurobiologie, Martinsried, Germany
    PLoS Genet 8:e1002768. 2012
    ..These results cast light on a cellular mechanism by which a noxious event induces different dopamine signals to a single brain structure to synthesize an aversive memory...
  71. doi AMP kinase activation mitigates dopaminergic dysfunction and mitochondrial abnormalities in Drosophila models of Parkinson's disease
    Chee Hoe Ng
    National Neuroscience Institute, Singapore 308433
    J Neurosci 32:14311-7. 2012
    ..Together, our results suggest the relevance of mitochondrial-associated pathway in LRRK2 and parkin-related pathogenesis, and that AMPK activation may represent a potential therapeutic strategy for these familial forms of PD...
  72. pmc Dopaminergic expression of the Parkinsonian gene LRRK2-G2019S leads to non-autonomous visual neurodegeneration, accelerated by increased neural demands for energy
    Samantha Hindle
    Department of Biology, University of York, York YO10 5DD, UK
    Hum Mol Genet 22:2129-40. 2013
    ....
  73. pmc Aconitase causes iron toxicity in Drosophila pink1 mutants
    Giovanni Esposito
    VIB Center for the Biology of Disease, Leuven, Belgium
    PLoS Genet 9:e1003478. 2013
    ..Thus our data indicate that superoxide-dependent [4Fe-4S] inactivation defines a potential pathogenic cascade that acts independent of mitophagy and links iron toxicity to mitochondrial failure in a PD-relevant model...
  74. doi A single dopamine pathway underlies progressive locomotor deficits in a Drosophila model of Parkinson disease
    Thomas Riemensperger
    Genetics and Physiopathology of Neurotransmission, Neurobiology Unit, CNRS, ESPCI ParisTech, 10 rue Vauquelin, 75005 Paris, France Molecular Neurobiology of Behaviour, Johann Friedrich Blumenbach Institute, Georg August University of Goettingen, Schwann Schleiden Research Center, Julia Lermontowa Weg 3, 37077 Goettingen, Germany Electronic address
    Cell Rep 5:952-60. 2013
    ..This suggests that modulation of the mushroom body β' lobes by this dopaminergic pathway is specifically required for an efficient control of startle-induced locomotion in flies. ..
  75. pmc Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease
    Roberta Tufi
    MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK
    Nat Cell Biol 16:157-66. 2014
    ..We propose that targeting strategies enhancing nucleotide synthesis pathways may reverse mitochondrial dysfunction and rescue neurodegeneration in PD and, potentially, other diseases linked to mitochondrial impairment. ..
  76. ncbi Dopaminergic modulation of motor neuron activity and neuromuscular function in Drosophila melanogaster
    R L Cooper
    Nerve Muscle Group, Thomas Hunt Morgan School of Biological Sciences, University of Kentucky, Lexington 40506 0225, USA
    Comp Biochem Physiol B Biochem Mol Biol 122:199-210. 1999
    ..The effects are presynaptic in causing a reduction in the number of vesicles that are stimulated to be released due to neural activity...
  77. ncbi Compartmentalization of neuronal and peripheral serotonin synthesis in Drosophila melanogaster
    W S Neckameyer
    Department of Pharmacological and Physiological Science, St Louis, University School of Medicine, MO 63104, USA
    Genes Brain Behav 6:756-69. 2007
    ..We also show that DTPHu functions in vivo as a phenylalanine hydroxylase in addition to its role as the peripheral TPH in Drosophila, and is critical for non-neuronal developmental events...
  78. doi Increased dopamine level enhances male-male courtship in Drosophila
    Tong Liu
    Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Neurosci 28:5539-46. 2008
    ..Our results indicate that the high intensity of male-male interaction shown by these manipulated males was related to their altered sensory perception of other males...
  79. ncbi Sexual behavior mutants revisited: molecular and cellular basis of Drosophila mating
    D Yamamoto
    ERATO Yamamoto Behavior Genes Project, Mitsubishi Kasei Institute of Life Sciences, Machida, Tokyo, Japan
    Cell Mol Life Sci 56:634-46. 1999
    ..The issue as to how the mutations that reduce female sexual receptiveness, e.g. dissatisfaction (dsf), spinster (spin) and chaste (cht), affect the structure and/or function of this neural center deserves to be addressed urgently...
  80. doi Neurotoxicity of fungal volatile organic compounds in Drosophila melanogaster
    Arati A Inamdar
    Department of Plant Biology and Pathology, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, USA
    Toxicol Sci 117:418-26. 2010
    ..Ingestion of the antioxidant, vitamin E, improved the survival span and delayed the VOC-mediated changes in dopaminergic neurons, indicating that the VOC-mediated toxicity was due, in part, to generation of reactive oxygen species...
  81. pmc Immunological detection of phenylalanine hydroxylase protein in Drosophila melanogaster
    F J Silva
    Departament de Genetica, Universitat de Valencia, Burjassot, Spain
    Biochem J 287:85-9. 1992
    ..Demonstration of this CRM as the PAH protein comes from the correlation between the decreased PAH enzyme activities of two mutant strains and their decreased amounts of CRM by Western blotting...
  82. ncbi A genetic analysis of aromatic amino acid hydroxylases involvement in DOPA synthesis during Drosophila adult development
    A C Piedrafita
    Departament de Genetica, Universitat de Valencia, Spain
    Insect Biochem Mol Biol 24:581-8. 1994
    ..Meanwhile the altered profiles of the Hnr3 and ple/TM3 strains directly implicate the phenylalanine and tyrosine hydroxylase enzymes...
  83. ncbi The Drosophila islet gene governs axon pathfinding and neurotransmitter identity
    S Thor
    Molecular Neurobiology Laboratory, The Salk Institute, San Diego, California 92186, USA
    Neuron 18:397-409. 1997
    ..Ectopic expression of islet induces both specific alterations in pathfinding and changes in neurotransmitter identity. These findings indicate that islet coordinately controls two distinct aspects of neuronal identity...
  84. ncbi A new role for catecholamines: ontogenesis
    R G Pendleton
    Department of Biology, Temple University, Philadelphia, PA 19122, USA
    Trends Pharmacol Sci 19:248-51. 1998
  85. pmc The catecholamines up (Catsup) protein of Drosophila melanogaster functions as a negative regulator of tyrosine hydroxylase activity
    D G Stathakis
    Department of Biology, University of Virginia, Charlottesville, Virginia 22903 2477, USA
    Genetics 153:361-82. 1999
    ..and biochemical analyses of Catecholamines up (Catsup), a gene that encodes a negative regulator of tyrosine hydroxylase (TH) activity...
  86. ncbi Chip is an essential cofactor for apterous in the regulation of axon guidance in Drosophila
    D J van Meyel
    The Salk Institute for Biological Studies, PO Box 85800, San Diego, CA 92186, USA
    Development 127:1823-31. 2000
    ....
  87. ncbi Tissue-specific developmental requirements of Drosophila tyrosine hydroxylase isoforms
    Florence Friggi-Grelin
    Laboratoire de Genetique et Physiologie du Developpement, Developmental Biology Institute of Marseille, Campus de Luminy, Marseille Cedex 9, France
    Genesis 35:175-84. 2003
    b>Drosophila tyrosine hydroxylase (DTH) is a key enzyme in dopamine (DA) biosynthesis, which is expressed in neural and hypodermal DA-synthesizing cells...
  88. ncbi Targeted expression of tetanus toxin reveals sets of neurons involved in larval locomotion in Drosophila
    Maximiliano L Suster
    Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK
    J Neurobiol 55:233-46. 2003
    ..The results presented here provide a basis for future genetic studies of motor control in the Drosophila larva...
  89. ncbi Could a loss of alpha-synuclein function put dopaminergic neurons at risk?
    Ruth G Perez
    Department of Neurology, University of Pittsburgh, BST South S 510, Pittsburgh, PA 15213, USA
    J Neurochem 89:1318-24. 2004
    ..entirely elucidated, one function appears to be as a normal regulatory protein that can bind to and inhibit tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis...
  90. ncbi Cell biology. Of grainy heads and broken skins
    Nicholas Harden
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, V5A 1S6 Canada
    Science 308:364-5. 2005
  91. ncbi Biochemical conservation of recombinant Drosophila tyrosine hydroxylase with its mammalian cognates
    Wendi S Neckameyer
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Biochem Genet 43:425-43. 2005
    ..Fundamental regulation of dopamine occurs via tyrosine hydroxylase (TH), the first and rate-limiting enzyme in the catecholamine biosynthetic pathway...
  92. pmc Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models
    Antony A Cooper
    School of Biological Sciences, University of Missouri Kansas City, Kansas City, MO 64110, USA
    Science 313:324-8. 2006
    ..Thus, synucleinopathies may result from disruptions in basic cellular functions that interface with the unique biology of particular neurons to make them especially vulnerable...
  93. pmc Drosophila dopamine synthesis pathway genes regulate tracheal morphogenesis
    Anita Hsouna
    Department of Pathology and Laboratory Medicine, and Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA
    Dev Biol 308:30-43. 2007
    ..Specifically, Punch (Pu) and pale (ple) mutants with reduced dopamine synthesis show ectopic/aberrant migration, while Catecholamines up (Catsup) ..
  94. pmc Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons
    Mari Palgi
    Institute of Biotechnology, University of Helsinki, 00014, Helsinki, Finland
    Proc Natl Acad Sci U S A 106:2429-34. 2009
    ..The rescue experiments confirm DmMANF as a functional ortholog of the human MANF gene thus opening the window for comparative studies of this protein family with potential for the treatment of Parkinson's disease...
  95. pmc Reduction of dopamine level enhances the attractiveness of male Drosophila to other males
    Tong Liu
    Institute of Neuroscience, State Key Laboratory for Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 4:e4574. 2009
    ..Our finding provides insight into the relationship between the dopamine reduction and male-male courtship behavior, and hints dopamine level is important for controlling Drosophila courtship behavior...
  96. pmc Targeted manipulation of serotonergic neurotransmission affects the escalation of aggression in adult male Drosophila melanogaster
    Olga V Alekseyenko
    Neurobiology Department, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 5:e10806. 2010
    ..By separately manipulating 5HT- and DA- neuron systems, we collected evidence demonstrating a direct role for 5HT in the escalation of aggression in Drosophila...
  97. ncbi Genes for sexual behavior
    D Yamamoto
    ERATO Yamamoto Behavior Genes Project, JST, Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    Biochem Biophys Res Commun 246:1-6. 1998
    ..This strategy of artificial control of fly behavior opens up an avenue for studies to identify the neural center for individual behavioral actions...
  98. ncbi Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles
    C W Wittmann
    Department of Pathology, Division of Neuropathology, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Room 514, Boston, MA 02115, USA
    Science 293:711-4. 2001
    ..This fly model may allow a genetic analysis of the cellular mechanisms underlying tau neurotoxicity...
  99. ncbi An epidermal barrier wound repair pathway in Drosophila is mediated by grainy head
    Kimberly A Mace
    Section of Cell and Developmental Biology, Division of Biology, University of California, San Diego, La Jolla, CA 92093, USA
    Science 308:381-5. 2005
    ..The conservation of this Grh-dependent pathway suggests that the repair of insect cuticle and mammal skin is controlled by an ancient, shared control system for constructing and healing the animal body surface barrier...
  100. ncbi Cell biology: master regulators of sealing and healing
    Brian Stramer
    Department of Physiology and Biochemistry, University of Bristol, UK
    Curr Biol 15:R425-7. 2005
    ..Yet new evidence suggests a conserved transcription factor, Grainyhead, controls both their development and the means by which both structures repair themselves...
  101. ncbi An ancient control of epithelial barrier formation and wound healing
    Bernard Moussian
    Max Planck Institut fuer Entwicklungsbiologie, Tuebingen, Germany
    Bioessays 27:987-90. 2005
    ..A key role is carried out by Grainy head, a phylogenetically conserved transcription factor expressed in epidermal cells in nematodes, flies, frogs, mice and humans...

Research Grants9

  1. MOLECULAR ANALYSIS OF THE DROSOPHILA GABA TRANSPORTERS
    Wendi Neckameyer; Fiscal Year: 2001
    ....
  2. Hormonal Factors and Recruitment of Neurons into the Stress Response Circuitry
    Wendi S Neckameyer; Fiscal Year: 2010
    ..This will provide a unique and innovative approach to modeling the development and organization of the stress circuitry in mammals. ..
  3. GENETIC MODEL OF NEURODEGENERATION
    Mel Feany; Fiscal Year: 2003
    ..A co-sponsor expert in human molecular genetics and neurodegenerative diseases has been selected to complement the primary laboratory's expertise in Drosophila molecular genetics and development. ..
  4. Non-invasive self administration methodology for mice
    Jay Hirsh; Fiscal Year: 2004
    ..These mice will be made available to the scientific community even before they are fully characterized. We will obtain these lines when available as homozygotes and test them in our paradigm. ..
  5. Genetic Dissection of Neurodegenerative Dementias
    Mel Feany; Fiscal Year: 2005
    ..These novel modifiers will represent candidate members of the presenilin complex, as well as upstream regulatory factors. ..
  6. Drosophila Model of Parkinson's Disease
    Mel Feany; Fiscal Year: 2005
    ..We can abolish inclusion formation in a-synuclein transgenic flies, and will determine if inclusions are required for neurotoxicity. ..
  7. Psychostimulant Response Pathways
    Jay Hirsh; Fiscal Year: 2006
    ..In the fourth aim, global changes in brain gene expression as a function of cocaine exposure and sensitization will be examined in order to identify new genes candidates involved in pathways modulating cocaine responses. ..
  8. Drosophila model of amyotrophic lateral sclerosis
    Mel Feany; Fiscal Year: 2007
    ..The role of excitotoxicity will be explored with genetic manipulations, in particular by overexpression of glial glutamate transporters. [unreadable] [unreadable]..
  9. Aging in Drosophila models of human neurodegeneration
    Mel Feany; Fiscal Year: 2007
    ..Pathways critical for these vulnerabilities will provide important therapeutic targets. [unreadable] [unreadable] [unreadable]..