Pdf

Summary

Gene Symbol: Pdf
Description: Pigment-dispersing factor
Alias: BcDNA:RH08487, CG6496, Dmel\CG6496, Drm-PDF, Drm-PDH, Drm-pdf, PAP, PDF, PDH, anon-WO0140519.261, anon-WO0140519.3, cPDH, pdf, CG6496 gene product from transcript CG6496-RA, CG6496-PA, PDF-associated peptide, PIGMENT DISPERSING FACTOR, Pdf-PA, Pigment-dispersing hormone-like peptide, pigment dispersing hormone, pigment dispersion factor, pigment-dispersing hormone
Species: fruit fly

Top Publications

  1. doi PDF-modulated visual inputs and cryptochrome define diurnal behavior in Drosophila
    Paola Cusumano
    Institut de Neurobiologie Alfred Fessard, Centre National de la Recherche Scientifique UPR 2216, Gif sur Yvette, France
    Nat Neurosci 12:1431-7. 2009
  2. ncbi Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest
    Thomas C Dockendorff
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuron 34:973-84. 2002
  3. ncbi The extraretinal eyelet of Drosophila: development, ultrastructure, and putative circadian function
    Charlotte Helfrich-Förster
    Zoological Institute Animal Physiology, University of Tubingen, D 72076 Tubingen, Germany
    J Neurosci 22:9255-66. 2002
  4. pmc Post-translational regulation of the Drosophila circadian clock requires protein phosphatase 1 (PP1)
    Yanshan Fang
    Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 21:1506-18. 2007
  5. ncbi A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila
    S C Renn
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Cell 99:791-802. 1999
  6. doi Peptidergic clock neurons in Drosophila: ion transport peptide and short neuropeptide F in subsets of dorsal and ventral lateral neurons
    Helena A D Johard
    Department of Zoology, Stockholm University, Stockholm, Sweden
    J Comp Neurol 516:59-73. 2009
  7. pmc DN1(p) circadian neurons coordinate acute light and PDF inputs to produce robust daily behavior in Drosophila
    Luoying Zhang
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Curr Biol 20:591-9. 2010
  8. pmc The neuropeptide PDF acts directly on evening pacemaker neurons to regulate multiple features of circadian behavior
    Bridget C Lear
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, USA
    PLoS Biol 7:e1000154. 2009
  9. ncbi Defining the role of Drosophila lateral neurons in the control of circadian rhythms in motor activity and eclosion by targeted genetic ablation and PERIOD protein overexpression
    E Blanchardon
    Institut de Neurobiologie Alfred Fessard, CNRS UPR 2216 NGI, av de la Terrasse, 91198 Gif sur Yvette, France
    Eur J Neurosci 13:871-88. 2001
  10. ncbi Coupled oscillators control morning and evening locomotor behaviour of Drosophila
    Dan Stoleru
    Howard Hughes Medical Institute and National Center for Behavioural Genomics, Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    Nature 431:862-8. 2004

Research Grants

  1. Molecular Neurobiology of Behavioral Rhythms
    Jeffrey Hall; Fiscal Year: 2006
  2. Formation of an Olfactory Sensory Map
    LESLIE VOSSHALL; Fiscal Year: 2006
  3. NEUROGENETICS OF DROSOPHILA REPRODUCTION
    LESLIE GRIFFITH; Fiscal Year: 2007
  4. A transgenic model of ocular inflammation
    Russell Van Gelder; Fiscal Year: 2007
  5. Exploring TSLP as a Key Initiator and Novel Therapeutic Target for Asthma
    Baohua Zhou; Fiscal Year: 2008
  6. Genetic Analysis of Olfactory Coding in Drosophilia
    LESLIE VOSSHALL; Fiscal Year: 2009
  7. Molecular Biology of the Odorant Receptors
    Leslie B Vosshall; Fiscal Year: 2011

Scientific Experts

Detail Information

Publications138 found, 100 shown here

  1. doi PDF-modulated visual inputs and cryptochrome define diurnal behavior in Drosophila
    Paola Cusumano
    Institut de Neurobiologie Alfred Fessard, Centre National de la Recherche Scientifique UPR 2216, Gif sur Yvette, France
    Nat Neurosci 12:1431-7. 2009
    ..In conditions in which CRY was not activated, flies depleted for pigment-dispersing factor (PDF) or its receptor lost the evening activity and displayed reversed PER oscillations in the LN-EO...
  2. ncbi Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest
    Thomas C Dockendorff
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuron 34:973-84. 2002
    ..Morphological analysis of neurons required for normal circadian behavior reveals subtle abnormalities, suggesting that defects in axonal pathfinding or synapse formation may cause the observed behavioral defects...
  3. ncbi The extraretinal eyelet of Drosophila: development, ultrastructure, and putative circadian function
    Charlotte Helfrich-Förster
    Zoological Institute Animal Physiology, University of Tubingen, D 72076 Tubingen, Germany
    J Neurosci 22:9255-66. 2002
    ..Thus a functional role in circadian entrainment first found in Bolwig's organ in the larva is retained in eyelet, the adult remnant of Bolwig's organ, even in the face of metamorphic restructuring...
  4. pmc Post-translational regulation of the Drosophila circadian clock requires protein phosphatase 1 (PP1)
    Yanshan Fang
    Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 21:1506-18. 2007
    ..We propose a modified model for post-translational regulation of the Drosophila clock, in which PP1 is critical for the rhythmic abundance of TIM/PER while PP2A also regulates the nuclear translocation of TIM/PER...
  5. ncbi A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila
    S C Renn
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Cell 99:791-802. 1999
    ..Here, we define two critical features of that mechanism in Drosophila. We first describe animals mutant for the pdf neuropeptide gene, which is expressed by most of the candidate pacemakers (LNv neurons)...
  6. doi Peptidergic clock neurons in Drosophila: ion transport peptide and short neuropeptide F in subsets of dorsal and ventral lateral neurons
    Helena A D Johard
    Department of Zoology, Stockholm University, Stockholm, Sweden
    J Comp Neurol 516:59-73. 2009
    ..Among these clock neurons, some pigment-dispersing factor (PDF)-positive and PDF-negative lateral neurons (LNs) are principal oscillators responsible for bouts of activity in the ..
  7. pmc DN1(p) circadian neurons coordinate acute light and PDF inputs to produce robust daily behavior in Drosophila
    Luoying Zhang
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Curr Biol 20:591-9. 2010
    ..The fruit fly Drosophila exhibits clock-driven activity increases that anticipate dawn and dusk and free-running rhythms under constant conditions. Flies also respond to the onset of light and dark with acute increases in activity...
  8. pmc The neuropeptide PDF acts directly on evening pacemaker neurons to regulate multiple features of circadian behavior
    Bridget C Lear
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, USA
    PLoS Biol 7:e1000154. 2009
    ..A subset of these neurons expresses the neuropeptide pigment dispersing factor (PDF), which is important for promoting morning behavior as well as maintaining robust free-running ..
  9. ncbi Defining the role of Drosophila lateral neurons in the control of circadian rhythms in motor activity and eclosion by targeted genetic ablation and PERIOD protein overexpression
    E Blanchardon
    Institut de Neurobiologie Alfred Fessard, CNRS UPR 2216 NGI, av de la Terrasse, 91198 Gif sur Yvette, France
    Eur J Neurosci 13:871-88. 2001
    The ventral lateral neurons (LNvs) of the Drosophila brain that express the period (per) and pigment dispersing factor (pdf) genes play a major role in the control of circadian activity rhythms...
  10. ncbi Coupled oscillators control morning and evening locomotor behaviour of Drosophila
    Dan Stoleru
    Howard Hughes Medical Institute and National Center for Behavioural Genomics, Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    Nature 431:862-8. 2004
    ..groups of circadian neurons: morning activity from the ventral lateral neurons that express the neuropeptide PDF, and evening activity from another group of cells, including the dorsal lateral neurons...
  11. pmc The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period
    Shawn A Cyran
    Department of Biology, New York University, New York, New York 10003, USA
    J Neurosci 25:5430-7. 2005
    ..Here, we show that these effects of SGG on PER nuclear accumulation require TIM. We propose a revised clock model that incorporates this tight kinase regulation of PER and TIM nuclear entry...
  12. ncbi Temperature cycles drive Drosophila circadian oscillation in constant light that otherwise induces behavioural arrhythmicity
    Taishi Yoshii
    Graduate School of Natural Science and Technology, Okayama University, Okayama 700 8530, Japan
    Eur J Neurosci 22:1176-84. 2005
    ..In flies lacking pigment-dispersing factor (PDF) or PDF-expressing cells, the anticipatory activity was relatively dispersed...
  13. pmc Drosophila CLOCK is constitutively expressed in circadian oscillator and non-oscillator cells
    Jerry H Houl
    Department of Biology and Biochemistry, University of Houston, Houston, TX, USA
    J Biol Rhythms 21:93-103. 2006
    ....
  14. ncbi Development and morphology of the clock-gene-expressing lateral neurons of Drosophila melanogaster
    Charlotte Helfrich-Förster
    University of Regensburg, Institute of Zoology, 93040 Regensburg, Germany
    J Comp Neurol 500:47-70. 2007
    ..whereby the latter group consists of four neurons that express the neuropeptide pigment-dispersing factor (PDF) and a fifth PDF-negative neuron...
  15. ncbi Separate sets of cerebral clock neurons are responsible for light and temperature entrainment of Drosophila circadian locomotor rhythms
    Yoko Miyasako
    Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan
    J Biol Rhythms 22:115-26. 2007
    ..In pdf(01) mutant flies that lack the neuropeptide PDF in the ventral groups of LNs, the onset of the evening peak was ..
  16. pmc Circadian remodeling of neuronal circuits involved in rhythmic behavior
    María Paz Fernández
    Laboratorio de Genética del Comportamiento, Instituto Leloir, Instituto de Investigaciones Bioquímicas Buenos Aires Consejo Nacional de Investigaciones Científicas y Técnicas IIBBA CONICET, Buenos Aires, Argentina
    PLoS Biol 6:e69. 2008
    ..Rhythmic release of pigment dispersing factor (PDF) has been proposed to propagate the time of day information from core pacemaker cells to downstream ..
  17. pmc Cyclical expression of Na+/K+-ATPase in the visual system of Drosophila melanogaster
    Jolanta Górska-Andrzejak
    Department of Cytology and Histology, Institute of Zoology, Jagiellonian University, Ingardena 6, Krakow 30 060, Poland
    J Insect Physiol 55:459-68. 2009
    ..express the clock gene per, and which closely contact the terminals of clock neurons immunoreactive to pigment dispersing factor. GFP fluorescence exhibited circadian oscillation in whole heads from Nrv2-GAL4+UAS-S65T-GFP flies, ..
  18. pmc Ventral lateral and DN1 clock neurons mediate distinct properties of male sex drive rhythm in Drosophila
    Shinsuke Fujii
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 107:10590-5. 2010
    ..Finally, we provide evidence that DN1s exert their roles in MSDR and SLR via distinct signaling pathways...
  19. ncbi Pigment-dispersing hormone-immunoreactive neurons in the nervous system of wild-type Drosophila melanogaster and of several mutants with altered circadian rhythmicity
    C Helfrich-Förster
    Botanisches Institut, Universitat Tubingen, Germany
    J Comp Neurol 337:177-90. 1993
    Antisera against the crustacean pigment-dispersing hormone (beta-PDH) were used in immunocytochemical preparations to investigate the anatomy of PDH-immunoreactive neurons in the nervous system of wild-type Drosophila melanogaster and in ..
  20. ncbi Spatial and temporal expression of the period and timeless genes in the developing nervous system of Drosophila: newly identified pacemaker candidates and novel features of clock gene product cycling
    M Kaneko
    Department of Biology, Brandeis University, Waltham, Massachusetts 02254, USA
    J Neurosci 17:6745-60. 1997
    ..Thus, the temporal expression of per and tim are regulated differentially in different cells. Furthermore, the light sensitivity associated with levels of the TIM protein is different from that in the heads of adult Drosophila...
  21. ncbi A role for the proteasome in the light response of the timeless clock protein
    N Naidoo
    Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 285:1737-41. 1999
    ..Degradation appeared to be preceded by tyrosine phosphorylation. Finally, TIM was ubiquitinated in response to light in cultured cells...
  22. ncbi Drosophila CRY is a deep brain circadian photoreceptor
    P Emery
    Department of Biology, National Science Foundation Center for Biological Timing, Waltham, Massachusetts 02454, USA
    Neuron 26:493-504. 2000
    ..These brain neurons therefore contain an identified deep brain photoreceptor, as well as the other circadian elements: a central pace-maker and a behavioral output system...
  23. ncbi A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK
    J A Williams
    Howard Hughes Medical Institute, Center for Sleep and Respiratory Neurobiology, Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 293:2251-6. 2001
    ..staining revealed a circadian oscillation of phospho-MAPK in the vicinity of nerve terminals containing pigment-dispersing factor (PDF), a secreted output from clock cells, suggesting a coupling of PDF to Ras/MAPK signaling.
  24. ncbi Larval optic nerve and adult extra-retinal photoreceptors sequentially associate with clock neurons during Drosophila brain development
    Sébastien Malpel
    Institut de Neurobiologie Alfred Fessard, CNRS UPR 2216 NGI, 91198 Gif sur Yvette, France
    Development 129:1443-53. 2002
    ..The Hofbauer-Buchner eyelet therefore does not appear to account for the previously described norpA-independent light input to the adult clock. This supports the existence of yet uncharacterized photoreceptive structures in Drosophila...
  25. ncbi Identification of genes involved in Drosophila melanogaster geotaxis, a complex behavioral trait
    Daniel P Toma
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, California 92121, USA
    Nat Genet 31:349-53. 2002
    ..We have thus determined the identities of several genes that contribute to the complex, polygenic behavior of geotaxis...
  26. ncbi Molecular cloning and functional expression of a Drosophila corazonin receptor
    Giuseppe Cazzamali
    Department of Cell Biology, Zoological Institute, University of Copenhagen, Universitetsparken 15, DK 2100, Copenhagen, Denmark
    Biochem Biophys Res Commun 298:31-6. 2002
    ..Furthermore, a receptor that is structurally very similar to the Drosophila corazonin receptor can be found in the genomic database from the malaria mosquito Anopheles gambiae...
  27. ncbi A role for casein kinase 2alpha in the Drosophila circadian clock
    Jui Ming Lin
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    Nature 420:816-20. 2002
    ..These effects are probably direct, as CK2alpha specifically phosphorylates Per in vitro. We propose that CK2 is an evolutionary link between the divergent circadian systems of animals, plants and fungi...
  28. ncbi Molecular identification of the first insect ecdysis triggering hormone receptors
    Annette Iversen
    Department of Cell Biology, Zoological Institute, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen, Denmark
    Biochem Biophys Res Commun 299:924-31. 2002
    ..Ecdysis (cuticle shedding) is an important behaviour, allowing growth and metamorphosis in insects and other arthropods. Our paper is the first report on the molecular identification of ecdysis triggering hormone receptors from insects...
  29. ncbi vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock
    Shawn A Cyran
    Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Cell 112:329-41. 2003
    ..Thus, VRI and PDP1, together with dClock itself, comprise a second feedback loop in the Drosophila clock that gives rhythmic expression of dClock, and probably of other genes, to generate accurate circadian rhythms...
  30. ncbi Drosophila clock can generate ectopic circadian clocks
    Jie Zhao
    Howard Hughes Medical Institute, Department of Biology, Brandeis University, Waltham, MA 02454, USA
    Cell 113:755-66. 2003
    ..We propose that Clock is uniquely able to induce and organize the core elements of interdependent feedback loops necessary for circadian rhythms...
  31. pmc Drosophila free-running rhythms require intercellular communication
    Ying Peng
    Department of Biology, Brandeis University, Waltham, Massachusetts, USA
    PLoS Biol 1:E13. 2003
    ..This persistent molecular rhythm requires pigment-dispersing factor (PDF), an LN(v)-specific neuropeptide, because the molecular oscillations are gradually lost when Pdf(01) mutant flies ..
  32. ncbi Novel features of cryptochrome-mediated photoreception in the brain circadian clock of Drosophila
    André Klarsfeld
    Institut de Neurobiologie Alfred Fessard, Centre National de la Recherche Scientifique, Unité Propre de Recherche 2216, 91198 Gif sur Yvette, France
    J Neurosci 24:1468-77. 2004
    ....
  33. ncbi Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A
    Sriram Sathyanarayanan
    Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell 116:603-15. 2004
    ..PP2A also affects PER phosphorylation in vitro and in vivo. We propose that the posttranslational mechanisms that drive cycling of PER require the rhythmic expression of PP2A...
  34. pmc Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogaster
    Gyunghee Lee
    Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996, USA
    Genetics 167:311-23. 2004
    ..From these findings, we propose another role for AKH in the regulation of starvation-induced foraging behavior...
  35. ncbi Comparative analysis of Corazonin-encoding genes (Crz's) in Drosophila species and functional insights into Crz-expressing neurons
    Youn J Choi
    Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996, USA
    J Comp Neurol 482:372-85. 2005
    ..Somata of Crz-neurons in the pars lateralis are located in the vicinity of terminals emanating from PDF-containing pacemaking neurons, indicating a functional connection between the two peptidergic nervous systems...
  36. ncbi PDF receptor signaling in Drosophila contributes to both circadian and geotactic behaviors
    Inge Mertens
    Laboratory of Developmental Physiology, Genomics and Proteomics, K U Leuven, Naamsestraat 59, B 3000 Leuven, Belgium
    Neuron 48:213-9. 2005
    The neuropeptide Pigment-Dispersing Factor (PDF) is a principle transmitter regulating circadian locomotor rhythms in Drosophila...
  37. ncbi Drosophila GPCR Han is a receptor for the circadian clock neuropeptide PDF
    Seogang Hyun
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Guseong dong, Yuseong Gu, Daejeon 305 701, Korea
    Neuron 48:267-78. 2005
    The pigment-dispersing factor (PDF) is a neuropeptide controlling circadian behavioral rhythms in Drosophila, but its receptor is not yet known...
  38. ncbi A resetting signal between Drosophila pacemakers synchronizes morning and evening activity
    Dan Stoleru
    Howard Hughes Medical Institute and National Center for Behavioral Genomics, Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    Nature 438:238-42. 2005
    ..of view: we and others have recently shown that a group of adult brain clock neurons expresses the neuropeptide PDF and controls morning activity (small LN(v) cells; M-cells), whereas another group of clock neurons controls evening ..
  39. ncbi Mapping of serotonin, dopamine, and histamine in relation to different clock neurons in the brain of Drosophila
    Yasutaka Hamasaka
    Department of Zoology, Stockholm University, SE 10691, Sweden
    J Comp Neurol 494:314-30. 2006
    ..Thus, serotonergic neurons form functional inputs on the s-LN(v)s in the larval brain and possibly also in adults...
  40. ncbi The ion channel narrow abdomen is critical for neural output of the Drosophila circadian pacemaker
    Bridget C Lear
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    Neuron 48:965-76. 2005
    ..In na mutants, expression of potassium currents and the key neuropeptide PDF are elevated, the latter consistent with reduced release...
  41. pmc Electrical hyperexcitation of lateral ventral pacemaker neurons desynchronizes downstream circadian oscillators in the fly circadian circuit and induces multiple behavioral periods
    Michael N Nitabach
    Department of Biology, New York University, New York, New York 10003, USA
    J Neurosci 26:479-89. 2006
    ..Thus, regulated electrical activity of the LNVs synchronize multiple oscillators in the fly circadian pacemaker circuit...
  42. ncbi Electrophysiological and anatomical characterization of PDF-positive clock neurons in the intact adult Drosophila brain
    Demian Park
    Department of Biology and Volen Center for Complex Systems, MS008, Brandeis University, 415 South St, Waltham, Massachusetts 02454 9110, USA
    J Neurophysiol 95:3955-60. 2006
    ..measure, for the first time, electrophysiological properties and anatomy of individual filled large lateral PDF-positive clock neurons, a cell group believed to be involved in synchronization of the clock in constant conditions...
  43. ncbi PDF cycling in the dorsal protocerebrum of the Drosophila brain is not necessary for circadian clock function
    Elzbieta Kula
    Department of Biology HHMI, Brandeis University, Waltham, MA 02454, USA
    J Biol Rhythms 21:104-17. 2006
    In Drosophila, the neuropeptide pigment-dispersing factor (PDF) is a likely circadian molecule, secreted by central pacemaker neurons (LNvs)...
  44. pmc Impaired clock output by altered connectivity in the circadian network
    María de la Paz Fernández
    Laboratorio de Genética del Comportamiento, Fundacion Instituto Leloir, Av Patricias Argentinas 435, 1405 Buenos Aires, Argentina
    Proc Natl Acad Sci U S A 104:5650-5. 2007
    ..small ventral lateral neurons can synchronize certain dorsal oscillators likely through the release of pigment dispersing factor (PDF), a neuropeptide central to the control of rhythmic rest-activity cycles...
  45. ncbi The Drosophila circadian network is a seasonal timer
    Dan Stoleru
    Howard Hughes Medical Institute and National Center for Behavioral Genomics, Department of Biology, Brandeis University, Waltham, MA 02454, USA
    Cell 129:207-19. 2007
    ..Together with the different entraining properties of the two clock centers, the results suggest that the functional organization of the network underlies the behavioral adjustment to variations in daylength and season...
  46. pmc Drosophila ebony activity is required in glia for the circadian regulation of locomotor activity
    Joowon Suh
    Department of Neuroscience, Tufts Center for Neuroscience Research and Sackler School of Biomedical Sciences, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Neuron 55:435-47. 2007
    ..Surprisingly, the ebony oscillation persists in flies lacking PDF neuropeptide, indicating it is regulated by an autonomous glial oscillator or another neuronal factor...
  47. pmc Light activates output from evening neurons and inhibits output from morning neurons in the Drosophila circadian clock
    Marie Picot
    Institut de Neurobiologie Alfred Fessard, CNRS UPR 2216, Gif sur Yvette, France
    PLoS Biol 5:e315. 2007
    ..Lateral neurons (LNs) that express the pigment-dispersing factor (PDF) drive morning activity, whereas PDF-negative LNs are required for the evening activity...
  48. pmc Dominant-negative CK2alpha induces potent effects on circadian rhythmicity
    Elaine M Smith
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, United States of America
    PLoS Genet 4:e12. 2008
    ..Taken together, these in vivo data implicate a central role of CK2alpha function in timing PER negative feedback in adult circadian neurons...
  49. doi Electrical silencing of PDF neurons advances the phase of non-PDF clock neurons in Drosophila
    Ying Wu
    Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT
    J Biol Rhythms 23:117-28. 2008
    ..We have previously determined that electrical silencing of the pigment dispersing factor (PDF)-expressing lateral-ventral (LN(V)) pacemaker subset of fly clock neurons via expression of an ..
  50. pmc Widespread receptivity to neuropeptide PDF throughout the neuronal circadian clock network of Drosophila revealed by real-time cyclic AMP imaging
    Orie T Shafer
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Neuron 58:223-37. 2008
    The neuropeptide PDF is released by sixteen clock neurons in Drosophila and helps maintain circadian activity rhythms by coordinating a network of approximately 150 neuronal clocks...
  51. pmc Function of the Shaw potassium channel within the Drosophila circadian clock
    James J Hodge
    Department of Physiology and Pharmacology, School of Medical Sciences, Bristol University, Bristol, United Kingdom
    PLoS ONE 3:e2274. 2008
    ....
  52. doi Pigment-dispersing factor (PDF) has different effects on Drosophila's circadian clocks in the accessory medulla and in the dorsal brain
    Corinna Wülbeck
    Institute of Zoology, University of Regensburg, Regensburg, Germany
    J Biol Rhythms 23:409-24. 2008
    The neuropeptide pigment-dispersing factor (PDF) is a key transmitter in the circadian clock of Drosophila melanogaster. Here we studied the rhythmic behavior of neural mutants with modified arborizations of the large PDF neurons...
  53. pmc The GABA(A) receptor RDL acts in peptidergic PDF neurons to promote sleep in Drosophila
    Brian Y Chung
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Curr Biol 19:386-90. 2009
    ..We assessed sleep-wake modulation by a core set of circadian pacemaker neurons that express the neuropeptide PDF. We find that disruption of PDF function increases sleep during the late night in light:dark and the first ..
  54. pmc Cellular dissection of circadian peptide signals with genetically encoded membrane-tethered ligands
    Charles Choi
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Curr Biol 19:1167-75. 2009
    ..As a novel tool for addressing such issues, we have developed genetically encoded neuropeptides covalently tethered to a glycosylphosphatidylinositol (GPI) glycolipid anchor on the plasma membrane ("t-peptides")...
  55. ncbi Pigment-dispersing hormone-like peptide in the nervous system of the flies Phormia and Drosophila: immunocytochemistry and partial characterization
    D R Nässel
    Department of Zoology, Stockholm University, Sweden
    J Comp Neurol 331:183-98. 1993
    beta-pigment-dispersing hormone (beta-PDH) isolated from the fiddler crab (Rao et al., '85) is a member of an octadecapeptide family of neuropeptides common to arthropods...
  56. ncbi Development of pigment-dispersing hormone-immunoreactive neurons in the nervous system of Drosophila melanogaster
    C Helfrich-Förster
    Botanisches Institut, Auf der Morgenstelle 1, Tubingen, Germany
    J Comp Neurol 380:335-54. 1997
    An antiserum against the crustacean pigment-dispersing hormone (PDH) was used to identify PDH-immunoreactive neurons in the developing nervous systems of wild type Drosophila melanogaster and the brain mutant disconnected...
  57. ncbi Robust circadian rhythmicity of Drosophila melanogaster requires the presence of lateral neurons: a brain-behavioral study of disconnected mutants
    C Helfrich-Förster
    Botanisches Institut, Tubingen, Germany
    J Comp Physiol A 182:435-53. 1998
    ..The presence of residual or bi-circadian rhythmicity in 20% of the flies without LNvs indicates that also other cells contribute to the rhythmic control of locomotor activity...
  58. ncbi Cycling vrille expression is required for a functional Drosophila clock
    J Blau
    Laboratory of Genetics, The Rockefeller University, New York, New York 10021, USA
    Cell 99:661-71. 1999
    ..We also show that dCLOCK and VRI independently regulate levels of a neuropeptide, pigment dispersing factor, which appears to regulate overt behavior.
  59. pmc Differential regulation of circadian pacemaker output by separate clock genes in Drosophila
    J H Park
    Department of Biology and National Science Foundation Center for Biological Timing, and Howard Hughes Medical Institute, Brandeis University, Waltham, MA 02454, USA
    Proc Natl Acad Sci U S A 97:3608-13. 2000
    Regulation of the Drosophila pigment-dispersing factor (pdf) gene products was analyzed in wild-type and clock mutants...
  60. ncbi Innervation of the ring gland of Drosophila melanogaster
    T Siegmund
    Freie Universitat Berlin, Institut fur Biologie, Genetik, Berlin 14195, Germany
    J Comp Neurol 431:481-91. 2001
    ..Most of the neurons presented here have not been described before. The enhancer trap lines labeling them will be valuable tools for the analysis of neuronal as well as genetic regulation in insect development...
  61. ncbi Multiple amidated neuropeptides are required for normal circadian locomotor rhythms in Drosophila
    P H Taghert
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 21:6673-86. 2001
    In Drosophila, the amidated neuropeptide pigment dispersing factor (PDF) is expressed by the ventral subset of lateral pacemaker neurons and is required for circadian locomotor rhythms...
  62. ncbi Circadian rhythms from flies to human
    Satchidananda Panda
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 417:329-35. 2002
    ..To gain the initial insights into circadian mechanisms, researchers turned to genetically tractable model organisms such as Drosophila...
  63. ncbi Sequential nuclear accumulation of the clock proteins period and timeless in the pacemaker neurons of Drosophila melanogaster
    Orie T Shafer
    Department of Zoology, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 22:5946-54. 2002
    ..The differing profiles of TIM and PER nuclear accumulation suggest that PER and TIM have distinct functions in the nuclei of vLNs...
  64. ncbi Molecular cloning and functional expression of a Drosophila receptor for the neuropeptides capa-1 and -2
    Annette Iversen
    Department of Cell Biology, Zoological Institute, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen, Denmark
    Biochem Biophys Res Commun 299:628-33. 2002
    ..Because capa-1 and -2 and related insect neuropeptides stimulate fluid secretion in insect Malpighian (renal) tubules, the identification of this first insect capa receptor will advance our knowledge on insect renal function...
  65. ncbi Genetic analysis of the circadian system in Drosophila melanogaster and mammals
    Ralf Stanewsky
    Universitat Regensburg, Institut fur Zoologie, Lehrstuhl für Entwicklungsbiologie, Universitatsstrasse 31, 93040 Regensburg, Germany
    J Neurobiol 54:111-47. 2003
    ..This review will try to give a comparative overview about the two systems, highlighting similarities as well as specifics of both insect and murine clocks...
  66. ncbi The bHLH protein Dimmed controls neuroendocrine cell differentiation in Drosophila
    Randall S Hewes
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Development 130:1771-81. 2003
    ..We propose that dimmed encodes an integral component of a novel mechanism by which diverse neuroendocrine lineages differentiate and maintain the pro-secretory state...
  67. ncbi Circadian control of eclosion: interaction between a central and peripheral clock in Drosophila melanogaster
    Edith M Myers
    The Department of Neuroscience, 232 Stemmler Hall, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Biol 13:526-33. 2003
    ..In addition, we demonstrate that pigment-dispersing factor (PDF), a neuropeptide secreted from LNs, is necessary for the PG clock and eclosion rhythms...
  68. pmc A recessive mutant of Drosophila Clock reveals a role in circadian rhythm amplitude
    Ravi Allada
    Howard Hughes Medical Institute and Department of Biology, Brandeis University, Waltham, MA 02454, USA
    EMBO J 22:3367-75. 2003
    ..Taken together with other data, we propose that Clk makes a major contribution to the strength and amplitude of circadian rhythms...
  69. ncbi Novel insights into the regulation of the timeless protein
    Lesley J Ashmore
    Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 23:7810-9. 2003
    ..We propose that TIM drives cycles of PER expression by regulating its stability, and in turn, PER retains TIM in the nucleus, either for the regulation of its own stability or for a novel nuclear role of TIM...
  70. ncbi Molecular cloning, functional expression, and gene silencing of two Drosophila receptors for the Drosophila neuropeptide pyrokinin-2
    Carina Rosenkilde
    Department of Cell Biology, Zoological Institute, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen, Denmark
    Biochem Biophys Res Commun 309:485-94. 2003
    ..The two Drosophila pyrokinin receptors are, to our knowledge, the first invertebrate pyrokinin receptors to be identified...
  71. ncbi A constitutively active cryptochrome in Drosophila melanogaster
    Stephane Dissel
    Department of Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK
    Nat Neurosci 7:834-40. 2004
    ..These effects are similar to those seen in wild-type flies under continuous light and suggest a regulatory role for the C terminus of CRY on the photosensitive, photolyase-like part of the protein...
  72. ncbi The neuropeptide pigment-dispersing factor coordinates pacemaker interactions in the Drosophila circadian system
    Yiing Lin
    Department of Genetics, Washington University Medical School, St Louis, Missouri 63110, USA
    J Neurosci 24:7951-7. 2004
    In Drosophila, the neuropeptide pigment-dispersing factor (PDF) is required to maintain behavioral rhythms under constant conditions...
  73. ncbi Morning and evening peaks of activity rely on different clock neurons of the Drosophila brain
    Brigitte Grima
    Institut de Neurobiologie Alfred Fessard NGI, CNRS UPR 2216, Centre National de la Recherche Scientifique, av de la Terrasse, 91198 Gif sur Yvette, France
    Nature 431:869-73. 2004
    ..Period (PER) protein, including the ventral lateral neurons (LN(v)s), which express the Pigment-dispersing factor (PDF) neuropeptide, and the PDF-negative dorsal lateral neurons (LN(d)s)...
  74. pmc The novel Drosophila tim(blind) mutation affects behavioral rhythms but not periodic eclosion
    Corinna Wülbeck
    Universitat Regensburg, Institut fur Zoologie, Lehrstuhl für Entwicklungsbiologie, 93040 Regensburg, Germany
    Genetics 169:751-66. 2005
    ..Therefore it seems possible that TIM--in addition to its well-established role as core clock factor--functions as a clock output factor, involved in determining the period length of adult locomotor rhythms...
  75. ncbi A novel diuretic hormone receptor in Drosophila: evidence for conservation of CGRP signaling
    Erik C Johnson
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Biol 208:1239-46. 2005
    ..Therefore, it appears that both the molecular details as well as the functional organization of CGRP signaling have been conserved...
  76. ncbi Drosophila olfactory response rhythms require clock genes but not pigment dispersing factor or lateral neurons
    Xianju Zhou
    Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Biol Rhythms 20:237-44. 2005
    ..These results indicate that the circadian rhythms in olfactory behavior in Drosophila are driven by pacemakers that do not control the rest-activity cycle and are likely in the antennae...
  77. ncbi Widely distributed Drosophila G-protein-coupled receptor (CG7887) is activated by endogenous tachykinin-related peptides
    Ryan T Birse
    Department of Zoology, Stockholm University, SE 10691 Stockholm, Sweden
    J Neurobiol 66:33-46. 2006
    ..Our findings suggest that DTKR is a DTK receptor in Drosophila and that this ligand-receptor system plays multiple functional roles...
  78. ncbi A G protein-coupled receptor, groom-of-PDF, is required for PDF neuron action in circadian behavior
    Bridget C Lear
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    Neuron 48:221-7. 2005
    The neuropeptide Pigment-Dispersing Factor (PDF) plays a critical role in mediating circadian control of behavior in Drosophila...
  79. ncbi Molecular identification of the first SIFamide receptor
    Lars M Jørgensen
    Center for Functional and Comparative Insect Genomics, Department of Cell Biology and Comparative Zoology, Institute of Biology, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Biochem Biophys Res Commun 340:696-701. 2006
    ..This paper is the first report on the identification of a SIFamide receptor...
  80. ncbi Functional analysis of circadian pacemaker neurons in Drosophila melanogaster
    Dirk Rieger
    University of Regensburg, Institute of Zoology, 93040 Regensburg, Germany
    J Neurosci 26:2531-43. 2006
    ..This reveals an interesting deviation from the original Pittendrigh and Daan (1976) model and suggests that a subgroup of the ventral subset of the small LN acts as "main" oscillator controlling M and E activity bouts in Drosophila...
  81. pmc Reevaluation of Drosophila melanogaster's neuronal circadian pacemakers reveals new neuronal classes
    Orie Thomas Shafer
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 498:180-93. 2006
    ..Finally, we present molecular and anatomical evidence for unrecognized phenotypic diversity within each of four established classes of clock neurons...
  82. ncbi Single-cell peptidomics of drosophila melanogaster neurons identified by Gal4-driven fluorescence
    Susanne Neupert
    Institute of Zoology, Friedrich Schiller University Jena, Erbertstrasse 1, 07743 Jena, Germany
    Anal Chem 79:3690-4. 2007
    ..Two Gal4 lines were used here to identify pigment-dispersing factor (PDF) and hugin-expressing neurons...
  83. ncbi Intracellular Ca2+ regulates free-running circadian clock oscillation in vivo
    Marie C Harrisingh
    Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 27:12489-99. 2007
    ..These results suggest a role for intracellular Ca2+ signaling in regulating intrinsic cellular oscillation in vivo...
  84. ncbi Metabolic inactivation of the circadian transmitter, pigment dispersing factor (PDF), by neprilysin-like peptidases in Drosophila
    R Elwyn Isaac
    Faculty of Biological Sciences, University of Leeds, Leeds, UK
    J Exp Biol 210:4465-70. 2007
    Recent studies have firmly established pigment dispersing factor (PDF), a C-terminally amidated octodecapeptide, as a key neurotransmitter regulating rhythmic circadian locomotory behaviours in adult Drosophila melanogaster...
  85. doi Cryptochrome is present in the compound eyes and a subset of Drosophila's clock neurons
    Taishi Yoshii
    Institute of Zoology, University of Regensburg, 93040 Regensburg, Germany
    J Comp Neurol 508:952-66. 2008
    ....
  86. pmc Large ventral lateral neurons modulate arousal and sleep in Drosophila
    Vasu Sheeba
    Department of Physiology and Biophysics, University of California, Irvine, California 92697, USA
    Curr Biol 18:1537-45. 2008
    ..To determine whether the lLNvs are involved in arousal and sleep/wake behavior, we examined the effects of altered electrical excitation of the LNvs...
  87. pmc A functional misexpression screen uncovers a role for enabled in progressive neurodegeneration
    Carolina Rezaval
    Laboratorio de Genética del Comportamiento, Fundacion Instituto Leloir, Instituto de Investigaciones Bioquímicas Buenos Aires IIB BA, CONICET, Buenos Aires, Argentina
    PLoS ONE 3:e3332. 2008
    ..e., vulnerability of certain neuronal populations and progressive degeneration, offering a unique scenario in which to unravel the specific mechanisms in an easily tractable organism...
  88. pmc PDF cells are a GABA-responsive wake-promoting component of the Drosophila sleep circuit
    Katherine M Parisky
    Department of Biology, Brandeis University, Waltham, MA 02454 9110, USA
    Neuron 60:672-82. 2008
    ..We identify here the relevant Rdl-containing cells as PDF-expressing small and large ventral lateral neurons (LNvs) of the circadian clock...
  89. pmc Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brain
    Yuhua Shang
    Howard Hughes Medical Institute and National Center for Behavioral Genomics, Department of Biology, Brandeis University, Waltham, MA 02454, USA
    Proc Natl Acad Sci U S A 105:19587-94. 2008
    ..We focused on the unknown function of the 10 PDF-containing large ventral lateral neurons (l-LNvs) of the Drosophila circadian brain network and show here that ..
  90. pmc Analysis of neuropeptide expression and localization in adult drosophila melanogaster central nervous system by affinity cell-capture mass spectrometry
    Joanne Y Yew
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Proteome Res 8:1271-84. 2009
    ..Neuropeptide profiling also was performed on targeted populations of cells which were enriched with immunoaffinity purification using a genetically expressed marker...
  91. doi The neuropeptide pigment-dispersing factor adjusts period and phase of Drosophila's clock
    Taishi Yoshii
    Institute of Zoology, University of Regensburg, 93040 Regensburg, Germany
    J Neurosci 29:2597-610. 2009
    The neuropeptide pigment-dispersing factor (PDF) is a key transmitter in the circadian clock of Drosophila melanogaster...
  92. pmc Perturbing dynamin reveals potent effects on the Drosophila circadian clock
    Valerie L Kilman
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, United States of America
    PLoS ONE 4:e5235. 2009
    ..To address this question, we expressed a temperature-sensitive, dominant negative allele of the fly homolog of dynamin called shibire(ts1) (shi(ts1)), an active component in membrane vesicle scission...
  93. pmc A role for microRNAs in the Drosophila circadian clock
    Sebastian Kadener
    National Center for Behavioral Genomics and Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    Genes Dev 23:2179-91. 2009
    ..Moreover, clk transgenes harboring mutated bantam sites in their 3' UTRs rescue rhythms of clk mutant flies much less well than wild-type CLK transgenes...
  94. pmc An isoform-specific mutant reveals a role of PDP1 epsilon in the circadian oscillator
    Xiangzhong Zheng
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 29:10920-7. 2009
    ..In addition, expression of PDF (pigment-dispersing factor) is reduced in a subset of the central clock cells...
  95. doi Blocking endocytosis in Drosophila's circadian pacemaker neurons interferes with the endogenous clock in a PDF-dependent way
    Corinna Wülbeck
    University of Regensburg, Institute of Zoology, Germany
    Chronobiol Int 26:1307-22. 2009
    The neuropeptide pigment-dispersing factor (PDF) plays an essential role in the circadian clock of the fruit fly Drosophila melanogaster, but many details of PDF signaling in the clock network are still unknown...
  96. pmc PDF receptor expression reveals direct interactions between circadian oscillators in Drosophila
    Seol Hee Im
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Comp Neurol 518:1925-45. 2010
    ..neurons (the small and large lateral neurons [LNvs]) express a neuropeptide called pigment-dispersing factor (PDF) whose signaling is often equated with M oscillator output...
  97. pmc Clock and cycle limit starvation-induced sleep loss in Drosophila
    Alex C Keene
    Biology Department, New York University, New York, NY 10003, USA
    Curr Biol 20:1209-15. 2010
    ..These findings show that Clk and cyc act during starvation to modulate the conflict of whether flies sleep or search for food...
  98. pmc Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila
    Elzbieta Kula-Eversole
    Howard Hughes Medical Institute, National Center for Behavioral Genomics, Department of Biology, Brandeis University, Waltham, MA 02454, USA
    Proc Natl Acad Sci U S A 107:13497-502. 2010
    ..and characterized two adjacent but distinct groups of Drosophila adult circadian neurons: the 8 small and 10 large PDF-expressing ventral lateral neurons (s-LNvs and l-LNvs, respectively)...
  99. doi Evening circadian oscillator as the primary determinant of rhythmic motivation for Drosophila courtship behavior
    Yasutaka Hamasaka
    Ishida Group of Clock Genes, Institute for Biomedical Research, National Institute of Advanced Industrial Science and Technology AIST, Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Genes Cells 15:1240-8. 2010
    ..These findings suggested that the NPF-negative LNds and DN1s of E cells include cells essential for circadian CP behavior in Drosophila...
  100. pmc The novel gene twenty-four defines a critical translational step in the Drosophila clock
    Chunghun Lim
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    Nature 470:399-403. 2011
    ..Taken together, these data indicate that TYF potently activates PER translation in pacemaker neurons to sustain robust rhythms, revealing a new and important role for translational control in the Drosophila circadian clock...
  101. pmc The E3 ubiquitin ligase CTRIP controls CLOCK levels and PERIOD oscillations in Drosophila
    Angélique Lamaze
    Institut de Neurobiologie Alfred Fessard, CNRS UPR3294, F 91190 Gif sur Yvette, France
    EMBO Rep 12:549-57. 2011
    ..The control of CLOCK protein levels does not require PERIOD. Thus, CTRIP seems to regulate the pace of the oscillator by controlling the stability of both the activator and the repressor of the feedback loop...

Research Grants7

  1. Molecular Neurobiology of Behavioral Rhythms
    Jeffrey Hall; Fiscal Year: 2006
    ..of chronobiology in this model system may provide insights into the nature of certain rhythm-related disorders of humans, some of which are associated with genetic variations of Drosophila clock gene orthologs [unreadable] [unreadable]..
  2. Formation of an Olfactory Sensory Map
    LESLIE VOSSHALL; Fiscal Year: 2006
    ..The health relatedness of these studies is that cellular and molecular factors that regulate axonal pathfinding may have direct application to neurological and psychiatric disorders with a developmental basis. ..
  3. NEUROGENETICS OF DROSOPHILA REPRODUCTION
    LESLIE GRIFFITH; Fiscal Year: 2007
    ..melanogaster ..
  4. A transgenic model of ocular inflammation
    Russell Van Gelder; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  5. Exploring TSLP as a Key Initiator and Novel Therapeutic Target for Asthma
    Baohua Zhou; Fiscal Year: 2008
    ..Our goal is to elucidate the roles of thymic stromal lymphopoietin (TSLP) in the pathogenesis of asthma and explore TSLP as a novel therapeutic target to prevent and/or control the disease. [unreadable] [unreadable] [unreadable]..
  6. Genetic Analysis of Olfactory Coding in Drosophilia
    LESLIE VOSSHALL; Fiscal Year: 2009
    ..The health relatedness of these studies is that an understanding of circuits underlying sensory perception is relevant for brain disorders with a neurological or psychiatric basis. ..
  7. Molecular Biology of the Odorant Receptors
    Leslie B Vosshall; Fiscal Year: 2011
    ..The Health-Relatedness of this proposal is that such chemical agents may act to reduce infectious disease transmission by vector insects in the future. ..