Genomes and Genes
Gene Symbol: p
Alias: CG9770, Dmel\CG9770, HPS5, NP_649810, dHPS5, snb, CG9770 gene product from transcript CG9770-RB, CG9770-PA, CG9770-PB, CG9770-PC, drosophila Hermansky-Pudlak syndrome 5 subunit, p-PA, p-PB, p-PC, pink-peach, sunburst
Species: fruit fly
- Not just pretty eyes: Drosophila eye-colour mutations and lysosomal deliveryV Lloyd
Dept of Biology and Biochemistry, Mt Allison University, Sackville, NB, Canada
Trends Cell Biol 8:257-9. 1998..Thus, classical work describing more than 85 eye-colour mutations and their genetic interactions offers a remarkable, untapped resource for the genetic analysis of protein delivery to lysosomes...
- The Drosophila pigmentation gene pink (p) encodes a homologue of human Hermansky-Pudlak syndrome 5 (HPS5)Juan M Falcon-Perez
Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Traffic 8:154-68. 2007..Here, we report that the gene encoding the Drosophila ortholog of the HPS5 subunit of BLOC-2 is identical to the granule group gene pink (p), which was first studied in 1910 but had not been ..
- The pink gene encodes the Drosophila orthologue of the human Hermansky-Pudlak syndrome 5 (HPS5) geneMonika Syrzycka
Simon Fraser University, Department of Molecular Biology and Biochemistry, 8888 University Drive, Burnaby, BC V5A 1S6, Canada
Genome 50:548-56. 2007..An examination of the chromosomal positioning of Drosophila HPS gene orthologues suggested that CG9770, the Drosophila HPS5 orthologue, might correspond to the pink locus...
- Male-killing Spiroplasma induces sex-specific cell death via host apoptotic pathwayToshiyuki Harumoto
Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Japan
PLoS Pathog 10:e1003956. 2014..These observations suggest that neither quantity nor proliferation of Spiroplasma cells but some Spiroplasma-derived factor(s) may be responsible for the expression of the male-killing phenotype. ..
- Early origin of genes encoding subunits of biogenesis of lysosome-related organelles complex-1, -2 and -3Verónica T Cheli
Department of Human Genetics, David Geffen School of Medicine, University of California, Gonda 6357B, 695 Charles E Young Dr S, Los Angeles, CA 90095 7088, USA
Traffic 11:579-86. 2010..Potential orthologs of Mon1 and Ccz1 were found in humans and several other eukaryotes...
- Eye color as an indicator of behavior: revisiting Worthy and ScottVicky L Elias
Department of Sociology, Oklahoma State University, USA
Psychol Rep 102:759-78. 2008..melanogaster pointed to significant behavioral differences among cell-defect groups, indicating that the cell defect which causes eye color, rather than eye color itself, may serve as a crude indicator of behavior...
- Cargo sorting to lysosome-related organelles regulates siRNA-mediated gene silencingDinari A Harris
Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA
J Cell Biol 194:77-87. 2011..Negative regulation is also not linked to sorting into all LROs but only a specific class of pigment LRO. Thus, regulation of siRNA activity is tied to sorting of specific types of cargo to particular LROs...
- A genetic suppressor of two dominant temperature-sensitive lethal proteasome mutants of Drosophila melanogaster is itself a mutated proteasome subunit genePeter J Neuburger
Department of Biology, Syracuse University, Syracuse, New York 13244, USA
Genetics 173:1377-87. 2006..While Prosbeta2(1) shows a modest increase in the number of defective mitotic figures, there were no defects seen with the other two mutants, other than slightly reduced mitotic indexes...
- Persistence time of loss-of-function mutations at nonessential loci affecting eye color in Drosophila melanogasterLev Y Yampolsky
Dept of Biological Sciences, East Tennessee State University, Johnson City, TN 37614 1710, USA
Genetics 171:2133-8. 2005..In both cases, deleterious alleles are apparently eliminated by selection against heterozygous individuals, which show no visible phenotypic differences from wild type...
- Entry is a rate-limiting step for viral infection in a Drosophila melanogaster model of pathogenesisSara Cherry
Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
Nat Immunol 5:81-7. 2004..Thus, this virus model provides a sensitive and efficient approach for identifying components required for pathogenesis...
- Enhancer of garnet/deltaAP-3 is a cryptic allele of the white gene and identifies the intracellular transport system for the white proteinVett K Lloyd
Department of Zoology, University of British Columbia, Vancouver, Canada
Genome 45:296-312. 2002..This observation supports a role for these genes in intracellular transport and leads to a model whereby incorrect sorting of the white gene product can explain the pigmentation phenotypes of an entire group of eye-color genes...
- Multi-organellar disorders of pigmentation: intracellular traffic jams in mammals, flies and yeastR A Spritz
Human Medical Genetics Program, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, B161, Denver, CO 80262, USA
Trends Genet 15:337-40. 1999..Recent discoveries show that several of these mutations directly affect components in the pathway of organelle-specific protein trafficking, and provide new insights into the relationships of these pathways in mammals, flies and yeast...
- A sex-influenced modifier in Drosophila that affects a broad spectrum of target loci including the histone repeatsU Bhadra
Division of Biological Sciences, University of Missouri Columbia 65211, USA
Genetics 146:903-17. 1997..Thus, Low is a modifier that plays a role in modulating the expression of genes governing various processes including pigment deposition, eye development, chromosomal proteins and position effect variegation...
- The homeobox gene cut interacts genetically with the homeotic genes proboscipedia and AntennapediaL A Johnston
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
Genetics 149:131-42. 1998..Our results implicate ct in the regulation of expression and/or function of two homeotic genes and document a new role of ct in the control of segmental identity...
- Cytogenic analysis of chromosome 3 in Drosophila melanogaster: mapping of the proximal portion of the right armI W Duncan
Genetics 80:733-52. 1975....
- Temperature-sensitive mutations in Drosophila melanogaster. XII. The genetic and developmental effects of dominant lethals on chromosome 3J J Holden
Genetics 73:445-58. 1973..Only DTS-4 exhibited dominant lethality in triploid females...
- Genetic damage at specific gene loci in Drosophila with betatron X-raysM L Alexander
Genetics 81:493-500. 1975..Although the two types of irradiations differ by an ion density of approximately ten, the amount and types of inheritable genetic damage induced by the two radiations in mature sperm were not significantly different...
- Genetic and biochemical characterization of little isoxanthopterin (lix), a gene controlling dihydropterin oxidase activity in Drosophila melanogasterF J Silva
Department de Genetica, Universitat de Valencia, Burjassot, Spain
Mol Gen Genet 230:97-103. 1991..Isoxanthopterin was quantitated in strains carrying deficiencies for the region in which lix has been mapped by recombination. This allowed us to assign the lix locus to the 7D10-7F1-2 segment of the X chromosome...
- Tissue specific effects of ommochrome pathway mutations in Drosophila melanogasterR Tearle
Department of Genetics and Human Variation, La Trobe University, Bundoora, Victoria, Australia
Genet Res 57:257-66. 1991..Two mutations affecting the red eye pigments (drosopterins), bw and mal, do not substantially perturb brown pigment synthesis in any of the four organs...
- Genetic location and biochemical characterization of eye-colour mutants from natural populations of Drosophila melanogasterM L Aparisi
Departamento de Genetica, Facultad de Ciencias Biologicas, Universidad de Valencia, Burjassot, Spain
Genome 33:203-8. 1990..The eye-colour mutants show large effects on the red and brown pigments. The high variability of the eye-colour loci is discussed in relation to the mutation and selection hypotheses...
- Interacting proteins identified by genetic interactions: a missense mutation in alpha-tubulin fails to complement alleles of the testis-specific beta-tubulin gene of Drosophila melanogasterT S Hays
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309 0347
Mol Cell Biol 9:875-84. 1989..Thus, the failure to complement appears to require the presence of the altered alpha-tubulin encoded by the nc33 allele, which may act as a structural poison when incorporated into either the tubulin heterodimer or microtubules...
- Genetic and molecular mapping of chromosome region 85A in Drosophila melanogasterW K Jones
T H Morgan School of Biological Sciences, University of Kentucky, Lexington 40506
Genetics 120:733-42. 1988..The breakpoint sites of a number of 85A chromosome rearrangements were localized on the molecular map, thereby delimiting regions of the DNA that contain the various genetic complementation groups...
- A development genetic analysis of the gene regulator of postbithorax in Drosophila melanogasterM Bender
Dev Biol 119:418-32. 1987..A possible formal relationship between Rg-pbx, ftz, and the postbithorax (pbx) locus is proposed...
- Mutations that encode partially functional beta 2 tubulin subunits have different effects on structurally different microtubule arraysM T Fuller
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309 0347
J Cell Biol 107:141-52. 1988....
- hunchback, a gene required for segmentation of an anterior and posterior region of the Drosophila embryoR Lehmann
Dev Biol 119:402-17. 1987..Heterozygous mutant embryos derived from a homozygous mutant germ line develop normally, indicating that maternal gene expression is not required for normal development...
- Characterization of sepiapterin reductase activity from Drosophila melanogasterP Ruiz-Vázquez
Departamento de Genetica, Universitat de Valencia, Spain
Comp Biochem Physiol B Biochem Mol Biol 113:131-6. 1996..0. A study of the activity in different eye-color mutant strains revealed significantly decreased levels in clot, red Malpighian tubules and garnet...
- Genetic and developmental relationships between two alkaline phosphatases in Drosophilia melanogasterB B Wallis
Biochem Genet 2:141-58. 1968
- Genetic analysis of B2t, the structural gene for a testis-specific beta-tubulin subunit in Drosophila melanogasterK J Kemphues
Genetics 105:345-56. 1983..All four mutant genes encode beta 2-tubulin subunits that are synthesized at normal rates but do not accumulate. All mutants are completely male sterile as homozygotes...
- Mutation in a testis-specific beta-tubulin in Drosophila: analysis of its effects on meiosis and map location of the geneK J Kemphues
Cell 21:445-51. 1980..Chromosomal events unrelated to microtubule function, such as replication and condensation, occur normally. Results obtained during mapping of the B2t locus strongly suggest a haplo-insufficient site at or closely linked to this locus...
- Effects of the maleless mutation on X and autosomal gene expression in Drosophila melanogasterJ C Hiebert
Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138
Genetics 136:913-26. 1994..These observations suggest that if mle plays a role in the discrimination of the X and the autosomes, it may do so by modification of the effects of dosage sensitive regulatory genes...
- MORGAN's hypothesis of the genetic control of developmentR Falk
Department of Genetics, Hebrew University of Jerusalem, Israel
Genetics 134:671-4. 1993
- Characterization of the mus308 gene in Drosophila melanogasterE A Leonhardt
Department of Genetics, University of California, Davis 95616
Genetics 133:87-96. 1993..In addition, observations of elevated embryo mortality are potentially explained by an aberrant distribution of nuclear material in early embryos which is similar to that seen in the mutant giant nuclei...
- Isolation of 88F actin mutants of Drosophila melanogaster and possible alterations in the mutant actin structuresH S An
Department of Physics, Graduate School of Science, University of Tokyo, Japan
J Mol Biol 260:492-505. 1996..On the basis of these phenotypes and the known atomic structure of actin, possible alterations in the structure of actin brought about by these mutations are discussed...
- Genetic analysis of oxygen defense mechanisms in Drosophila melanogaster and identification of a novel behavioural mutant with a Shaker phenotypeJ M Humphreys
Department of Molecular Biology and Genetics, University of Guelph, ON, Canada
Genome 39:749-57. 1996..Two mutants were identified as being new alleles of the previously identified doublesex (dsx) and pink (p) genes...
- Drosophila immunity: genes on the third chromosome required for the response to bacterial infectionL P Wu
Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, College Park, Maryland 20742, USA
Genetics 159:189-99. 2001..These genetic studies should provide a basis for a comprehensive understanding of the genetic control of immune responses in Drosophila...
- GENETIC STUDIES OF MARGARITA ISLAND ECTODERMAL DYSPLASIARichard Spritz; Fiscal Year: 2002..The last aim is to initiate studies to determine the function of the ED4 gene. ..
- STUDIES OF HUMAN PIGMENTATION DISORDERSRichard Spritz; Fiscal Year: 2005....
- Missing Mutations in Oculocutaneous and Ocular AlbinismRichard Spritz; Fiscal Year: 2006..Together, these studies should provide a greatly improved understanding of the molecular pathogenesis of oculocutaneous and ocular albinism. [unreadable] [unreadable]..
- GENE DISCOVERY FOR CRANIOFACIAL DISORDERSRichard Spritz; Fiscal Year: 2007..Isolated, "non-syndromic" CL/P (nsCb'P) is the most common craniofacial birth defect, accounting for -70% of all cases of CL/P...