okr

Summary

Gene Symbol: okr
Description: okra
Alias: CG3736, DhR54, DmRAD54, DmRad54, Dmel\CG3736, Dmrad54, OKR, Okr, RAD54, RAD54L, Rad54, Ras54, rad54, CG3736 gene product from transcript CG3736-RA, CG3736-PA, okr-PA
Species: fruit fly

Top Publications

  1. pmc The Drosophila melanogaster RAD54 homolog, DmRAD54, is involved in the repair of radiation damage and recombination
    R Kooistra
    Department of Radiation Genetics and Chemical Mutagenesis, MGC, Leiden University, The Netherlands
    Mol Cell Biol 17:6097-104. 1997
  2. pmc The Drosophila zinc finger protein trade embargo is required for double strand break formation in meiosis
    Cathleen M Lake
    Stowers Institute for Medical Research, Kansas City, Missouri, United States of America
    PLoS Genet 7:e1002005. 2011
  3. pmc Meiotic recombination provokes functional activation of the p53 regulatory network
    Wan Jin Lu
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 328:1278-81. 2010
  4. pmc Drosophila PCH2 is required for a pachytene checkpoint that monitors double-strand-break-independent events leading to meiotic crossover formation
    Eric F Joyce
    Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
    Genetics 181:39-51. 2009
  5. pmc Drosophila brca2 is required for mitotic and meiotic DNA repair and efficient activation of the meiotic recombination checkpoint
    Martha Klovstad
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
    PLoS Genet 4:e31. 2008
  6. pmc Multiple-pathway analysis of double-strand break repair mutations in Drosophila
    Dena M Johnson-Schlitz
    Department of Genetics, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS Genet 3:e50. 2007
  7. pmc An essential role for Drosophila hus1 in somatic and meiotic DNA damage responses
    Uri Abdu
    Department of Life Sciences, National Institute for Biotechnology in the Negev, Ben Gurion University, Beer Sheva, 84105, Israel
    J Cell Sci 120:1042-9. 2007
  8. pmc Temporal analysis of meiotic DNA double-strand break formation and repair in Drosophila females
    S Mehrotra
    Waksman Institute, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America
    PLoS Genet 2:e200. 2006
  9. pmc Mutations in the extra sex combs and Enhancer of Polycomb genes increase homologous recombination in somatic cells of Drosophila melanogaster
    Angela M Holmes
    Department of Biochemistry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario N6A 5C1, Canada
    Genetics 172:2367-77. 2006
  10. pmc Lig4 and rad54 are required for repair of DNA double-strand breaks induced by P-element excision in Drosophila
    Ron J Romeijn
    Department of Toxicogenetics, Leiden University Medical Center LUMC, 2333 AL, Leiden, The Netherlands
    Genetics 169:795-806. 2005

Scientific Experts

  • Marco Milan
  • A Pastink
  • Cathleen M Lake
  • J Thacker
  • J D Schnorr
  • P G de Buendía
  • Uri Abdu
  • Anja C Nagel
  • Sarit Cohen
  • Wan Jin Lu
  • Vassilios Alexiadis
  • A Dekanty
  • Sharon Kim
  • Annika Wylie
  • Kimberly A Collins
  • Matthew C LaFave
  • Manish Mishra
  • Kim S McKim
  • John M Abrams
  • Rotem Kadir
  • Ron J Romeijn
  • Jennifer A Armstrong
  • Irene Chiolo
  • Marcin M Gorski
  • Elizabeth A Manheim
  • Ana Bozas
  • R Scott Hawley
  • Jonathan I Schneiderman
  • Eric F Joyce
  • Hifzur R Siddique
  • Martha Klovstad
  • Kamilla Sofie Pedersen
  • Ivy E McDaniel
  • Dena M Johnson-Schlitz
  • Debbie S Wei
  • Vitor Barbosa
  • Angela M Holmes
  • R Kooistra
  • S Mehrotra
  • K S McKim
  • Anne Laurencon
  • R Bhagat
  • Leon H Mullenders
  • Burnley R Jaklevic
  • Wouter Ferro
  • James T Kadonaga
  • Seth D Findley
  • Janet K Jang
  • Lakshmi Bugga
  • L Barrio
  • Eugenie S Hong
  • Rebecca Zabinsky
  • Parimal A Deodhar
  • Rebecca G Edwards
  • Jay R Unruh
  • Danny E Miller
  • Rachel J Nielsen
  • Kathryn E Malanowski
  • Brian D Slaughter
  • Eric P Stoffregen
  • Justin P Blumenstiel
  • Kathryn P Kohl
  • ZuLin Yu
  • Jeff Sekelsky
  • Michael Buszczak
  • Alejandro D'Brot
  • Sabrina L Andersen
  • Kimberly S Box
  • Julie K Holsclaw
  • Anoja G Perera
  • Lewis J Overton
  • P Pragya
  • A K Shukla
  • U N Dwivedi
  • R C Murthy
  • David de Pomerai
  • D Kar Chowdhuri
  • A Sharma
  • Anna Bakhrat
  • Ronit Tokarsky
  • Serafin U Colmenares
  • Gary H Karpen
  • Aris Polyzos
  • Sylvain V Costes
  • Aki Minoda
  • Joseph Chapo
  • Ignasi Roig
  • Jonathan K Trautman
  • Kelly J Beumer
  • Kami Ahmad

Detail Information

Publications50

  1. pmc The Drosophila melanogaster RAD54 homolog, DmRAD54, is involved in the repair of radiation damage and recombination
    R Kooistra
    Department of Radiation Genetics and Chemical Mutagenesis, MGC, Leiden University, The Netherlands
    Mol Cell Biol 17:6097-104. 1997
    ..Here the isolation and functional characterization of the RAD54 homolog of the fruit fly Drosophila melanogaster, DmRAD54, are described. The putative Dmrad54 protein displays 46 to 57% identity to its homologs from yeast and mammals...
  2. pmc The Drosophila zinc finger protein trade embargo is required for double strand break formation in meiosis
    Cathleen M Lake
    Stowers Institute for Medical Research, Kansas City, Missouri, United States of America
    PLoS Genet 7:e1002005. 2011
    ..We speculate that Trem may act by either directing the binding of Mei-P22 to preferred sites of DSB formation or by altering chromatin structure in a manner that allows Mei-P22 to form foci...
  3. pmc Meiotic recombination provokes functional activation of the p53 regulatory network
    Wan Jin Lu
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 328:1278-81. 2010
    ..Our findings establish a physiological role for p53 in meiosis and suggest that tumor-suppressive functions may have been co-opted from primordial activities linked to recombination...
  4. pmc Drosophila PCH2 is required for a pachytene checkpoint that monitors double-strand-break-independent events leading to meiotic crossover formation
    Eric F Joyce
    Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 8020, USA
    Genetics 181:39-51. 2009
    ..Interestingly, PCH2-dependent delays in prophase may allow additional crossovers to form...
  5. pmc Drosophila brca2 is required for mitotic and meiotic DNA repair and efficient activation of the meiotic recombination checkpoint
    Martha Klovstad
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
    PLoS Genet 4:e31. 2008
    ..In addition, Brca2 co-immunoprecipitates with the checkpoint protein Rad9, suggesting a direct role for Brca2 in the transduction of the meiotic recombination checkpoint signal...
  6. pmc Multiple-pathway analysis of double-strand break repair mutations in Drosophila
    Dena M Johnson-Schlitz
    Department of Genetics, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS Genet 3:e50. 2007
    ....
  7. pmc An essential role for Drosophila hus1 in somatic and meiotic DNA damage responses
    Uri Abdu
    Department of Life Sciences, National Institute for Biotechnology in the Negev, Ben Gurion University, Beer Sheva, 84105, Israel
    J Cell Sci 120:1042-9. 2007
    ..These results demonstrate that hus1 is essential for the activation of the meiotic checkpoint and that hus1 is also required for the organization of the oocyte DNA, a function that might be independent of the meiotic checkpoint...
  8. pmc Temporal analysis of meiotic DNA double-strand break formation and repair in Drosophila females
    S Mehrotra
    Waksman Institute, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America
    PLoS Genet 2:e200. 2006
    ..From a comparison of the frequency of gamma-His2Av foci and crossovers, it appears that Drosophila females have only a weak mechanism to ensure a crossover in the presence of a low number of DSBs...
  9. pmc Mutations in the extra sex combs and Enhancer of Polycomb genes increase homologous recombination in somatic cells of Drosophila melanogaster
    Angela M Holmes
    Department of Biochemistry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario N6A 5C1, Canada
    Genetics 172:2367-77. 2006
    ..We propose that esc and E(Pc) mutants enhance homologous recombination by modulating the histone acetylation status of histone H4 at the double-strand break...
  10. pmc Lig4 and rad54 are required for repair of DNA double-strand breaks induced by P-element excision in Drosophila
    Ron J Romeijn
    Department of Toxicogenetics, Leiden University Medical Center LUMC, 2333 AL, Leiden, The Netherlands
    Genetics 169:795-806. 2005
    ..the repair of these breaks, the w(hd) P-element was mobilized in flies carrying mutant alleles of either lig4 or rad54. The survival of both lig4- and rad54-deficient males was reduced to 25% in comparison to the wild type, ..
  11. ncbi Studies on crossover-specific mutants and the distribution of crossing over in Drosophila females
    R Bhagat
    Waksman Institute and Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Cytogenet Genome Res 107:160-71. 2004
    ..This may be the activation of a regulatory system that ensures at least one crossover per chromosome, and which compensates for an absence of crossovers by attempting to generate them at random locations...
  12. pmc A large-scale screen for mutagen-sensitive loci in Drosophila
    Anne Laurencon
    Section of Molecular and Cellular Biology, University of California, Davis, California 95616, USA
    Genetics 167:217-31. 2004
    ..At least one allele of each new gene identified in this study is available at the Bloomington Stock Center...
  13. pmc The Drosophila melanogaster DNA Ligase IV gene plays a crucial role in the repair of radiation-induced DNA double-strand breaks and acts synergistically with Rad54
    Marcin M Gorski
    Department of Toxicogenetics, Leiden University Medical Center, 2333 AL, Leiden, The Netherlands
    Genetics 165:1929-41. 2003
    ..To determine the relative contribution of NHEJ and homologous recombination (HR) in Drosophila, Lig4; Rad54 double-mutant flies were generated...
  14. pmc The Drosophila spn-D gene encodes a RAD51C-like protein that is required exclusively during meiosis
    Uri Abdu
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Genetics 165:197-204. 2003
    ..As there is no apparent ortholog of the meiosis-specific DMC1 gene in the Drosophila genome, and given their meiosis-specific requirement, we suggest that spn-B and spn-D may have a function comparable to DMC1...
  15. ncbi The Synaptonemal complex component C(2)M regulates meiotic crossing over in Drosophila
    Elizabeth A Manheim
    Waksman Institute and Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 8020, USA
    Curr Biol 13:276-85. 2003
    ..Previous studies have suggested that the SC is required for meiotic crossing over in Drosophila. However, only one component of this structure, C(3)G, has been identified in Drosophila...
  16. ncbi Activation of a meiotic checkpoint during Drosophila oogenesis regulates the translation of Gurken through Chk2/Mnk
    Uri Abdu
    HHMI, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Curr Biol 12:1645-51. 2002
    ..However, the components of this checkpoint in flies have not been completely elucidated...
  17. ncbi Activation of a meiotic checkpoint regulates translation of Gurken during Drosophila oogenesis
    A Ghabrial
    HHMI, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nat Cell Biol 1:354-7. 1999
    ..We also show that Vasa is a target of this meiotic checkpoint, and so may mediate the checkpoint-dependent translational regulation of Gurken...
  18. ncbi Relationship of DNA double-strand breaks to synapsis in Drosophila
    Janet K Jang
    Waksman Institute and Department of Genetics, Rutgers, The State University of New Jersey, 190 Frelinghuysen Rd, Piscataway, New Jersey 08854 8020, USA
    J Cell Sci 116:3069-77. 2003
    ..Furthermore, mutations in Drosophila Rad54 (okr) and Rad51 (spnB) homologs cause delayed and prolonged gamma-HIS2AV staining, suggesting that double-strand ..
  19. pmc An RNAi-Based Candidate Screen for Modifiers of the CHD1 Chromatin Remodeler and Assembly Factor in Drosophila melanogaster
    Sharon Kim
    The W M Keck Science Department, Claremont McKenna College, Scripps College and Pitzer College, California 91711
    G3 (Bethesda) 6:245-54. 2015
    ..Our results indicate that CHD1 may act in opposition to other remodeling factors, including INO80, and that the recruitment of CHD1 to active genes by RTF1 is conserved in flies. ..
  20. pmc Vilya, a component of the recombination nodule, is required for meiotic double-strand break formation in Drosophila
    Cathleen M Lake
    Stowers Institute for Medical Research, Kansas City, United States
    elife 4:e08287. 2015
    ..Thus Vilya links the mechanism of DSB formation to either the selection of those DSBs that will become crossovers or to the actual process of crossing over. ..
  21. pmc Corolla is a novel protein that contributes to the architecture of the synaptonemal complex of Drosophila
    Kimberly A Collins
    Stowers Institute for Medical Research, Kansas City, Missouri 64110
    Genetics 198:219-28. 2014
    ..These observations help provide a more complete model of SC structure and function in Drosophila females...
  22. doi Aneuploidy and tumorigenesis in Drosophila
    Marco Milan
    ICREA, Spain Institute for Research in Biomedicine IRB Barcelona, Baldiri Reixac, 10 12, 08028 Barcelona, Spain Electronic address
    Semin Cell Dev Biol 28:110-5. 2014
    ..Here we discuss the role of aneuploidy in tumorigenesis in light of the contribution of Drosophila epithelial cancer models and propose a stress-induced tumor-promoting role of aneuploidy. ..
  23. doi Contributions of DNA repair, cell cycle checkpoints and cell death to suppressing the DNA damage-induced tumorigenic behavior of Drosophila epithelial cells
    A Dekanty
    Institute for Research in Biomedicine IRB Barcelona, Barcelona, Spain
    Oncogene 34:978-85. 2015
    ..The tumorigenic response of the tissue to IR is enhanced by depletion of Okra/DmRAD54 or spnA/DmRAD51--genes required for homologous recombination (HR) repair of DNA double-strand breaks in G2--and ..
  24. pmc p53 activity is selectively licensed in the Drosophila stem cell compartment
    Annika Wylie
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, United States
    elife 3:e01530. 2014
    ..Furthermore, the findings uncover ancestral links between p53 and aberrant proliferation that are independent of DNA breaks and predate evolution of the ARF/Mdm2 axis. DOI: http://dx.doi.org/10.7554/eLife.01530.001. ..
  25. pmc Sources and structures of mitotic crossovers that arise when BLM helicase is absent in Drosophila
    Matthew C LaFave
    Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599
    Genetics 196:107-18. 2014
    ..These findings provide important new insights into sources and structures of mitotic crossovers and functions of BLM helicase. ..
  26. pmc The development of a monoclonal antibody recognizing the Drosophila melanogaster phosphorylated histone H2A variant (γ-H2AV)
    Cathleen M Lake
    Stowers Institute for Medical Research, Kansas City, Missouri 64110
    G3 (Bethesda) 3:1539-43. 2013
    ....
  27. doi Transcriptomic analysis provides insights on hexavalent chromium induced DNA double strand breaks and their possible repair in midgut cells of Drosophila melanogaster larvae
    Manish Mishra
    Embryotoxicology Section and Environmental Toxicology Group, CSIR Indian Institute of Toxicology Research CSIR IITR, Lucknow 226001, Uttar Pradesh, India
    Mutat Res 747:28-39. 2013
    ..Along with this, DSBs generation in spn-A and okr [essential genes in homologous recombination repair (HR) pathway] mutants was also tested for the possible ..
  28. doi Cyclin G is involved in meiotic recombination repair in Drosophila melanogaster
    Anja C Nagel
    Institut fur Genetik, Universitat Hohenheim, Garbenstr 30, 70599 Stuttgart, Germany
    J Cell Sci 125:5555-63. 2012
    ..Therefore, we propose that CycG has a role in an early step of meiotic recombination repair, thereby affecting EGFR-mediated patterning processes during oogenesis...
  29. doi DNA damage induced by industrial solid waste leachates in Drosophila melanogaster: a mechanistic approach
    Hifzur R Siddique
    Embryotoxicology Section, Industrial Toxicology Research Centre, Lucknow, Uttar Pradesh, India
    Environ Mol Mutagen 49:206-16. 2008
    ..protein), mus201 (deficient in excision repair protein), mus308 (deficient in postreplication repair protein), and rad54 (deficient in double strand break repair protein) than in the OregonR(+) wild-type strain...
  30. ncbi Genomic integrity and the repair of double-strand DNA breaks
    A Pastink
    Sylvius Laboratory, Department of Radiation Genetics and Chemical Mutagenesis, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands
    Mutat Res 480:37-50. 2001
    ..This review summarizes our current knowledge about DSB-repair with emphasis on recent progress in understanding the precise biochemical activities of individual proteins involved...
  31. pmc Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair
    Irene Chiolo
    Department of Genome Dynamics, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Cell 144:732-44. 2011
    ..We propose that the spatial and temporal control of DSB repair in heterochromatin safeguards genome stability by preventing aberrant exchanges between repeats...
  32. pmc Localization of the Drosophila Rad9 protein to the nuclear membrane is regulated by the C-terminal region and is affected in the meiotic checkpoint
    Rotem Kadir
    Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    PLoS ONE 7:e38010. 2012
    ..Thus, by studying the localization pattern of DmRad9, our study reveals that the DmRad9A C-terminal region targets the protein to the nuclear membrane, where it might play a role in response to the activation of the meiotic checkpoint...
  33. pmc Extrachromosomal circular DNA of tandemly repeated genomic sequences in Drosophila
    Sarit Cohen
    Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv 69978, Israel
    Genome Res 13:1133-45. 2003
    ..Mutations in the genes okra, mus309, and mei41 did not affect eccDNA under normal conditions or following mutagen treatment, implying that eccDNA formation is different from known pathways of DNA repair...
  34. pmc A genetic screen for DNA double-strand break repair mutations in Drosophila
    Debbie S Wei
    Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genetics 177:63-77. 2007
    ..We show that Drosophila Rad51 and Rad54 are both required for homologous repair by gene conversion, but are dispensable for single-strand annealing repair...
  35. ncbi Maelstrom, a Drosophila spindle-class gene, encodes a protein that colocalizes with Vasa and RDE1/AGO1 homolog, Aubergine, in nuage
    Seth D Findley
    Department of Biochemistry, Box 357350, University of Washington, Seattle, WA 98195 7350, USA
    Development 130:859-71. 2003
    ..Furthermore, maelstrom mutant ovaries show mislocalization of two proteins involved in the microRNA and/or RNAi pathways, Dicer and Argonaute2, suggesting a potential connection between nuage and the microRNA-pathway...
  36. ncbi Relative contribution of DNA repair, cell cycle checkpoints, and cell death to survival after DNA damage in Drosophila larvae
    Burnley R Jaklevic
    MCD Biology, University of Colorado, Boulder, CO 80309, USA
    Curr Biol 14:23-32. 2004
    ..Cell cycle regulation and DNA repair appear essential for unicellular systems to survive DNA damage. The relative importance of these responses and apoptosis for surviving DNA damage in multicellular organisms remains unclear...
  37. ncbi A conserved N-terminal motif in Rad54 is important for chromatin remodeling and homologous strand pairing
    Vassilios Alexiadis
    Section of Molecular Biology, University of California, San Diego, La Jolla, California 92093 0347, USA
    J Biol Chem 279:27824-9. 2004
    The Swi2/Snf2-related protein Rad54 is a chromatin remodeling enzyme that is important for homologous strand pairing catalyzed by the eukaryotic recombinase Rad51...
  38. pmc Strand pairing by Rad54 and Rad51 is enhanced by chromatin
    Vassilios Alexiadis
    Section of Molecular Biology, University of California, San Diego, La Jolla, California 92093 0347, USA
    Genes Dev 16:2767-71. 2002
    We investigated the role of chromatin in the catalysis of homologous strand pairing by Rad54 and Rad51. Rad54 is related to the ATPase subunits of chromatin-remodeling factors, whereas Rad51 is related to bacterial RecA...
  39. pmc Ras1 interacts with multiple new signaling and cytoskeletal loci in Drosophila eggshell patterning and morphogenesis
    J D Schnorr
    Department of Biology, Whitman College, Walla Walla, Washington 99362, USA
    Genetics 159:609-22. 2001
    ..Mutations in Star and l(2)43Bb had no significant effect upon the lambdatop eggshell defect whereas smt3 and dock alleles significantly suppressed the lambdatop phenotype...
  40. ncbi Repair and consequences of double-strand breaks in DNA
    A Pastink
    Department of Radiation Genetics and Chemical Mutagenesis, MGC, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL, Leiden, Netherlands
    Mutat Res 428:141-56. 1999
  41. pmc The Drosophila melanogaster DmRAD54 gene plays a crucial role in double-strand break repair after P-element excision and acts synergistically with Ku70 in the repair of X-ray damage
    R Kooistra
    Department of Radiation Genetics and Chemical Mutagenesis, MGC, Leiden University Medical Center, Leiden, The Netherlands
    Mol Cell Biol 19:6269-75. 1999
    ..A Drosophila melanogaster strain deficient in the RAD54 homolog DmRAD54 is characterized by increased X-ray and methyl methanesulfonate (MMS) sensitivity...
  42. pmc A maternal screen for genes regulating Drosophila oocyte polarity uncovers new steps in meiotic progression
    Vitor Barbosa
    Howard Hughes Medical Institute and the Kimmel Center for Biology and Medicine, Skirball Institute, 540 First Avenue, New York, NY 10016, USA
    Genetics 176:1967-77. 2007
    ....
  43. ncbi Novel genetic screen for genes involved in posterior body patterning in Drosophila
    J E Wilson
    Department of Biological Sciences, Stanford University, California 94305 5020, USA
    Dev Genet 19:199-209. 1996
    ..These defects are distinct from previously described perturbations in oskar activity and provide new insights into the regulation of oskar...
  44. ncbi Search for DNA repair pathways in Drosophila melanogaster
    P G de Buendía
    Instituto de Genetica, Universidad de Los Andes, Bogota, Colombia
    Mutat Res 407:67-84. 1998
    ..A possible explanation could be a weaker control of post-replication repair mechanisms in Drosophila than in yeast. It is expected that this research could help for a better understanding of repair mechanisms in complex organisms...
  45. pmc The XNP remodeler targets dynamic chromatin in Drosophila
    Jonathan I Schneiderman
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:14472-7. 2009
    ..Thus, the XNP focus appears to be a functional genetic element that can contribute to gene silencing throughout the nucleus...
  46. pmc Genetic analysis of zinc-finger nuclease-induced gene targeting in Drosophila
    Ana Bozas
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah 84112 5650, USA
    Genetics 182:641-51. 2009
    ..The frequency of HR dropped significantly in flies homozygous for mutations in spnA (Rad51) or okr (Rad54), two components of the invasion-mediated synthesis-dependent strand annealing (SDSA) pathway...
  47. ncbi Drosophila oogenesis: versatile spn doctors
    J Morris
    Developmental Genetics Program, Skirball Institute, Howard Hughes Medical Institute, Department of Cell Biology, NYU School of Medicine, 540 First Avenue, New York, 10016, USA
    Curr Biol 9:R55-8. 1999
    ..Genes of the spindle class, which encode double-strand break repair enzymes and RNA helicases, affect oocyte polarity and the decision whether to differentiate as an oocyte or a nurse cell...
  48. pmc Metabolomic signatures of inbreeding at benign and stressful temperatures in Drosophila melanogaster
    Kamilla Sofie Pedersen
    Department of Biological Sciences, University of Aarhus, DK 8000 Aarhus C, Denmark
    Genetics 180:1233-43. 2008
    ....
  49. ncbi A surfeit of RAD51-like genes?
    J Thacker
    Medical Research Council, Radiation and Genome Stability Unit, Harwell, Oxfordshire, UK OX11 0RD
    Trends Genet 15:166-8. 1999
    ..The recent cloning and functional analysis of eukaryotic recombination genes suggests that at least part of the intricate mechanism involved is conserved from bacteria to humans, but is also yielding some surprises...
  50. pmc Investigations of CHD1 function in transcription and development of Drosophila melanogaster
    Ivy E McDaniel
    Joint Science Department, W M Keck Science Center, Scripps, Claremont McKenna, and Pitzer Colleges, Claremont, California 91711, USA
    Genetics 178:583-7. 2008
    ..These results clarify the roles of chromatin remodelers in transcription and provide novel insights into CHD1 function...