Nrx-IV

Summary

Gene Symbol: Nrx-IV
Description: Neurexin IV
Alias: CG682, CG6827, CT21123, Dmel\CG6827, Dnrx, NRX, NRX IV, Nrx, Nrx IV, NrxIV, Nx IV, l(3)68Ff, l(3)rsg23, nrx, nrx IV, nrx-IV, nrxIV, rsg23, CG6827 gene product from transcript CG6827-RB, CG6827-PA, CG6827-PB, Neurexin-4, Neurexin-IV, Nrx-IV-PA, Nrx-IV-PB, neurexin, neurexin 4, neurexin IV, neurexinIV, rose-gespleten region interval 23
Species: fruit fly

Top Publications

  1. ncbi A homologue of the vertebrate SET domain and zinc finger protein Blimp-1 regulates terminal differentiation of the tracheal system in the Drosophila embryo
    Teclise Ng
    Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore, 138673, Singapore
    Dev Genes Evol 216:243-52. 2006
  2. ncbi Axonal ensheathment and septate junction formation in the peripheral nervous system of Drosophila
    Swati Banerjee
    Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7545, USA
    J Neurosci 26:3319-29. 2006
  3. pmc Neuroglian, Gliotactin, and the Na+/K+ ATPase are essential for septate junction function in Drosophila
    Jennifer L Genova
    Department of Biology, Developmental, Cell, and Molecular Biology Group, Duke University, Durham, NC 27708, USA
    J Cell Biol 161:979-89. 2003
  4. ncbi The Na+/K+ ATPase is required for septate junction function and epithelial tube-size control in the Drosophila tracheal system
    Sarah M Paul
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA
    Development 130:4963-74. 2003
  5. ncbi The claudin-like megatrachea is essential in septate junctions for the epithelial barrier function in Drosophila
    Matthias Behr
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Am Fassberg, 37077 Gottingen, Germany
    Dev Cell 5:611-20. 2003
  6. ncbi Molecular organization of axo-glial junctions
    Manzoor A Bhat
    Department of Cell and Molecular Physiology, Neuroscience Center and Curriculum in Neurobiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Curr Opin Neurobiol 13:552-9. 2003
  7. ncbi Lachesin is a component of a septate junction-based mechanism that controls tube size and epithelial integrity in the Drosophila tracheal system
    Marta Llimargas
    Institut de Biologia Molecular de Barcelona, CSIC, 08034 Barcelona, Spain
    Development 131:181-90. 2004
  8. pmc Sinuous is a Drosophila claudin required for septate junction organization and epithelial tube size control
    Victoria M Wu
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Hogan Hall, Rm 2 100, Northwestern University, 2205 Tech Drive, Evanston, IL 60208 3500, USA
    J Cell Biol 164:313-23. 2004
  9. ncbi A junctional problem of apical proportions: epithelial tube-size control by septate junctions in the Drosophila tracheal system
    Victoria M Wu
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Hogan Hall Rm 2 100, 2205 Tech Dr, Evanston, Illinois 60208, USA
    Curr Opin Cell Biol 16:493-9. 2004
  10. ncbi Drosophila contactin, a homolog of vertebrate contactin, is required for septate junction organization and paracellular barrier function
    Catherine Faivre-Sarrailh
    Neurobiologie des Interactions Cellulaires et Neurophysiopathologie, UMR 6184 CNRS, Institut Jean Roche, Boulevard Pierre Dramard, 13916 Marseille Cedex 20, France
    Development 131:4931-42. 2004

Research Grants

  1. NEUREXIN IV, GROWTH CONTROL, AND CANCER
    Manzoor Bhat; Fiscal Year: 2002
  2. MOLECULAR MECHANISMS OF SCHWANN CELL MYELINATION
    Bruce Trapp; Fiscal Year: 2008
  3. Cellular Mechanisms for Oligodendrocyte Myelination
    Bruce D Trapp; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications87

  1. ncbi A homologue of the vertebrate SET domain and zinc finger protein Blimp-1 regulates terminal differentiation of the tracheal system in the Drosophila embryo
    Teclise Ng
    Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore, 138673, Singapore
    Dev Genes Evol 216:243-52. 2006
    ..Further, using genetic analysis, we demonstrate that its wild-type activity is critically required for the maturation of the tracheal system into properly differentiated tubes...
  2. ncbi Axonal ensheathment and septate junction formation in the peripheral nervous system of Drosophila
    Swati Banerjee
    Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7545, USA
    J Neurosci 26:3319-29. 2006
    ..SJs are formed between the inner and outer glial membranes. We also show that Neurexin IV, Contactin, and Neuroglian are coexpressed in the peripheral glial membranes and that these proteins exist as a ..
  3. pmc Neuroglian, Gliotactin, and the Na+/K+ ATPase are essential for septate junction function in Drosophila
    Jennifer L Genova
    Department of Biology, Developmental, Cell, and Molecular Biology Group, Duke University, Durham, NC 27708, USA
    J Cell Biol 161:979-89. 2003
    ..In addition to the previously known components Coracle (COR) and Neurexin (NRX), we show that four other proteins, Gliotactin, Neuroglian (NRG), and both the alpha and beta subunits of ..
  4. ncbi The Na+/K+ ATPase is required for septate junction function and epithelial tube-size control in the Drosophila tracheal system
    Sarah M Paul
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA
    Development 130:4963-74. 2003
    ....
  5. ncbi The claudin-like megatrachea is essential in septate junctions for the epithelial barrier function in Drosophila
    Matthias Behr
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Am Fassberg, 37077 Gottingen, Germany
    Dev Cell 5:611-20. 2003
    ..addition, we present evidence that Mega is essential for localization of the septate junction protein complex Coracle/Neurexin. The results indicate that claudin-like proteins are functionally conserved between vertebrates and Drosophila.
  6. ncbi Molecular organization of axo-glial junctions
    Manzoor A Bhat
    Department of Cell and Molecular Physiology, Neuroscience Center and Curriculum in Neurobiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Curr Opin Neurobiol 13:552-9. 2003
    ..In addition, new roles for axo-glial paranodal septate junctions have emerged, which suggest that the paranodal region may act as an ionic barrier and a molecular fence in myelinated axons...
  7. ncbi Lachesin is a component of a septate junction-based mechanism that controls tube size and epithelial integrity in the Drosophila tracheal system
    Marta Llimargas
    Institut de Biologia Molecular de Barcelona, CSIC, 08034 Barcelona, Spain
    Development 131:181-90. 2004
    ..In addition, mutations in genes encoding other components of the SJs produce a similar tracheal phenotype. These results point out a new role of the SJs in morphogenesis regulating cell adhesion and cell size...
  8. pmc Sinuous is a Drosophila claudin required for septate junction organization and epithelial tube size control
    Victoria M Wu
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Hogan Hall, Rm 2 100, Northwestern University, 2205 Tech Drive, Evanston, IL 60208 3500, USA
    J Cell Biol 164:313-23. 2004
    ..using a sinuous null mutation suggests that sinuous functions in the same pathway as the septate junction genes neurexin and scribble, but that nervana 2, convoluted, varicose, and cystic have functions not shared by sinuous...
  9. ncbi A junctional problem of apical proportions: epithelial tube-size control by septate junctions in the Drosophila tracheal system
    Victoria M Wu
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Hogan Hall Rm 2 100, 2205 Tech Dr, Evanston, Illinois 60208, USA
    Curr Opin Cell Biol 16:493-9. 2004
    ..Possible tube-size functions of septate junctions include patterning of the apical extracellular matrix and regulation of conserved cell polarity genes such as Scribble and Discs Large...
  10. ncbi Drosophila contactin, a homolog of vertebrate contactin, is required for septate junction organization and paracellular barrier function
    Catherine Faivre-Sarrailh
    Neurobiologie des Interactions Cellulaires et Neurophysiopathologie, UMR 6184 CNRS, Institut Jean Roche, Boulevard Pierre Dramard, 13916 Marseille Cedex 20, France
    Development 131:4931-42. 2004
    ..Mutational analyses have shown that vertebrate NCP1 and its Drosophila homolog, Neurexin IV (NRX IV) are required for the formation of SJs...
  11. pmc Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble
    Jennifer Zeitler
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA
    J Cell Biol 167:1137-46. 2004
    ..We suggest a model in which Scrib, via the activity of the LRR, governs proliferation primarily by regulating apicobasal polarity...
  12. ncbi GPCR signaling is required for blood-brain barrier formation in drosophila
    Tina Schwabe
    Laboratory of Developmental Neurogenetics, Rockefeller University, New York, NY 10021, USA
    Cell 123:133-44. 2005
    ..Our study demonstrates the importance of morphogenetic regulation in blood-brain barrier development and places GPCR signaling at its core...
  13. ncbi Septate-junction-dependent luminal deposition of chitin deacetylases restricts tube elongation in the Drosophila trachea
    Shenqiu Wang
    Department of Developmental Biology, Wenner Gren Institute, Stockholm University, Arrhenius Labs E3, S 10691 Stockholm, Sweden
    Curr Biol 16:180-5. 2006
    ..We propose that the subsequent structural modification of chitin by chitin binding deacetylases selectively instructs the termination of tube elongation to the underlying epithelium...
  14. ncbi Claudins in occluding junctions of humans and flies
    Mikio Furuse
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Trends Cell Biol 16:181-8. 2006
    ..Interestingly, claudin-like molecules have recently been identified in septate junctions of Drosophila. Here, we present an overview of recent progress in claudin studies conducted in mammals and flies...
  15. ncbi A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function
    S Baumgartner
    Friedrich Miescher Institute, Basel, Switzerland
    Cell 87:1059-68. 1996
    ..We have characterized a novel member of the neurexin family, Neurexin IV (NRX), which is localized to septate junctions (SJs) of epithelial and glial cells...
  16. ncbi Gliotactin and Discs large form a protein complex at the tricellular junction of polarized epithelial cells in Drosophila
    Joost Schulte
    Department of Zoology, University of British Columbia, Vancouver, V6T 1Z3, Canada
    J Cell Sci 119:4391-401. 2006
    ..Finally this work supports a model where Gliotactin and Dlg are components of a larger protein complex that links the converging SJs with the TCJ to create the transepithelial barrier...
  17. doi Organization and function of the blood-brain barrier in Drosophila
    Tobias Stork
    Institut fur Neurobiologie, Universitat Munster, D 48149 Münster Germany
    J Neurosci 28:587-97. 2008
    ....
  18. doi dGRASP-mediated noncanonical integrin secretion is required for Drosophila epithelial remodeling
    Hans Schotman
    The Cell Microscopy Centre, Department of Cell Biology, Institute of Biomembranes, University Medical Centre Utrecht, AZU Room G02 525, Heidelberglaan 100, 3584CX Utrecht, The Netherlands
    Dev Cell 14:171-82. 2008
    ..We speculate that this mechanism might be used during development as a means of targeting a specific subset of transmembrane proteins to the plasma membrane...
  19. pmc Septate junctions are required for ommatidial integrity and blood-eye barrier function in Drosophila
    Swati Banerjee
    Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Dev Biol 317:585-99. 2008
    ..We show that the localization of Neurexin IV (Nrx IV), a SJ-specific protein, coincides with the location of SJs in the cone and pigment cells...
  20. pmc On the role of the MAGUK proteins encoded by Drosophila varicose during embryonic and postembryonic development
    ANDRE BACHMANN
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstr 1, 40225 Dusseldorf, Germany
    BMC Dev Biol 8:55. 2008
    ..They often appear in different variants suggesting that they also mediate dynamic changes in the composition of the complexes...
  21. pmc The lateral mobility of cell adhesion molecules is highly restricted at septate junctions in Drosophila
    Monique Laval
    Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, UMR 6231 CNRS, Marseille, France
    BMC Cell Biol 9:38. 2008
    A complex of three cell adhesion molecules (CAMs) Neurexin IV(Nrx IV), Contactin (Cont) and Neuroglian (Nrg) is implicated in the formation of septate junctions between epithelial cells in Drosophila...
  22. pmc Neurexin IV and Wrapper interactions mediate Drosophila midline glial migration and axonal ensheathment
    Scott R Wheeler
    Department of Biochemistry and Biophysics, The University of North Carolina, Chapel Hill, NC 27599, USA
    Development 136:1147-57. 2009
    ..By contrast, Neurexin IV is present on the membranes of neurons and commissural axons, and is highly concentrated at their interfaces ..
  23. pmc CNTNAP2 and NRXN1 are mutated in autosomal-recessive Pitt-Hopkins-like mental retardation and determine the level of a common synaptic protein in Drosophila
    Christiane Zweier
    Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, 91054 Erlangen, Germany
    Am J Hum Genet 85:655-66. 2009
    Heterozygous copy-number variants and SNPs of CNTNAP2 and NRXN1, two distantly related members of the neurexin superfamily, have been repeatedly associated with a wide spectrum of neuropsychiatric disorders, such as developmental language ..
  24. pmc The Drosophila Claudin Kune-kune is required for septate junction organization and tracheal tube size control
    Kevin S Nelson
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
    Genetics 185:831-9. 2010
    ..Double- and triple-mutant combinations of Sinuous and Megatrachea with Kune-kune resemble the Kune-kune single mutant, suggesting that Kune-kune has a more central role in septate junction formation than either Sinuous or Megatrachea...
  25. pmc Drosophila neurexin IV interacts with Roundabout and is required for repulsive midline axon guidance
    Swati Banerjee
    Department of Cell and Molecular Physiology, University of North Carolina Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7545, USA
    J Neurosci 30:5653-67. 2010
    ..Here, we report that the Drosophila transmembrane septate junction-specific protein Neurexin IV (Nrx IV) functions in midline repulsive axon guidance...
  26. pmc Neurexin in embryonic Drosophila neuromuscular junctions
    Kaiyun Chen
    Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 5:e11115. 2010
    b>Neurexin is a synaptic cell adhesion protein critical for synapse formation and function. Mutations in neurexin and neurexin-interacting proteins have been implicated in several neurological diseases...
  27. doi Canoe functions at the CNS midline glia in a complex with Shotgun and Wrapper-Nrx-IV during neuron-glia interactions
    Jana Slováková
    Instituto de Neurociencias de Alicante, CSIC UMH, Sant Joan d Alacant, Alicante, Spain
    Development 138:1563-71. 2011
    ..unveil Cno function as a novel regulator of neuron-glia interactions, forming a complex with Shg, Wrapper and Neurexin IV, the homolog of vertebrate Caspr/paranodin...
  28. doi The regulation of glial-specific splicing of Neurexin IV requires HOW and Cdk12 activity
    Floriano Rodrigues
    Institut fur Neurobiologie, Universitat Munster, Badestrasse 9, 48149 Munster, Germany
    Development 139:1765-76. 2012
    ..In the fly BBB, glial cells establish intensive septate junctions that require the cell-adhesion molecule Neurexin IV. Alternative splicing generates two different Neurexin IV isoforms: Neurexin IV(exon3), which is found in cells ..
  29. ncbi Localization of apical epithelial determinants by the basolateral PDZ protein Scribble
    D Bilder
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 403:676-80. 2000
    ..Our results show that the lateral domain of epithelia, particularly the septate junction, functions in restricting apical membrane identity and correctly placing adherens junctions...
  30. ncbi Composition and formation of intercellular junctions in epithelial cells
    Elisabeth Knust
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstrasse 1, 40225 Dusseldorf, Germany
    Science 298:1955-9. 2002
    ..Comparisons between fly, worm, and vertebrate epithelia reveal marked similarities with respect to the molecules used, and pronounced differences in the organization of the junctions themselves...
  31. pmc Gliotactin, a novel marker of tricellular junctions, is necessary for septate junction development in Drosophila
    Joost Schulte
    Dept of Zoology, University of British Columbia, Vancouver, Canada
    J Cell Biol 161:991-1000. 2003
    ..In Gli mutants, localization of SJ markers neurexin-IV, discs large, and coracle are disrupted...
  32. pmc Drosophila coracle, a member of the protein 4.1 superfamily, has essential structural functions in the septate junctions and developmental functions in embryonic and adult epithelial cells
    R S Lamb
    Developmental, Cellular, and Molecular Biology Group, Duke University, Durham, North Carolina 27708 1000, USA
    Mol Biol Cell 9:3505-19. 1998
    ..1 superfamily members. These studies provide insights into a range of in vivo functions for coracle in developing embryos and adults...
  33. ncbi Neurexin IV, caspr and paranodin--novel members of the neurexin family: encounters of axons and glia
    H J Bellen
    Dept of Human and Molecular Genetics, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
    Trends Neurosci 21:444-9. 1998
    ..b>Neurexin IV, a molecular component of Drosophila septate junctions, has been shown to be essential for axonal insulation in ..
  34. ncbi Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing
    Katsuhiko Tabuchi
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Genomics 79:849-59. 2002
    ..We now show that Drosophila melanogaster and Caenorhabditis elegans express a single gene encoding only an alpha-neurexin, whereas humans and mice express three genes, each of which encodes alpha- and beta-neurexins transcribed from ..
  35. pmc A conserved functional domain of Drosophila coracle is required for localization at the septate junction and has membrane-organizing activity
    R E Ward
    Developmental, Cell, and Molecular Biology Group, Department of Zoology, Duke University, Durham, North Carolina 27708 1000, USA
    J Cell Biol 140:1463-73. 1998
    ..Furthermore, the localization of Coracle and the transmembrane protein Neurexin to the septate junction display an interdependent relationship, suggesting that Coracle and Neurexin interact ..
  36. ncbi The splicing factor crooked neck associates with the RNA-binding protein HOW to control glial cell maturation in Drosophila
    Gundula Edenfeld
    Institut fur Neurobiologie, Universitat Munster, Badestrasse 9, D 48149 Munster, Germany
    Neuron 52:969-80. 2006
    ....
  37. ncbi Discs Lost, a novel multi-PDZ domain protein, establishes and maintains epithelial polarity
    M A Bhat
    Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 96:833-45. 1999
    ..of development, DLT interacts with the apical determinant Crumbs (CRB) and the laterally localized protein Neurexin IV (NRX IV)...
  38. doi The CD59 family member Leaky/Coiled is required for the establishment of the blood-brain barrier in Drosophila
    Mubarak Hussain Syed
    Institut fur Neurobiologie, Universitat Munster, D 48149 Munster, Germany
    J Neurosci 31:7876-85. 2011
    ..In coiled mutants, the normal distribution of septate junction markers such as NeurexinIV, Coracle, or Discs large is disturbed...
  39. doi Epithelial septate junction assembly relies on melanotransferrin iron binding and endocytosis in Drosophila
    Katarína Tiklová
    Department of Developmental Biology, Wenner Gren Institute, Stockholm University, S 10691 Stockholm, Sweden
    Nat Cell Biol 12:1071-7. 2010
    ..Mouse MTf complements the defects of Drosophila MTf mutants. Drosophila provides the first genetic model for the functional dissection of MTf in epithelial junction assembly and morphogenesis...
  40. pmc The Drosophila blood brain barrier is maintained by GPCR-dependent dynamic actin structures
    Meital Hatan
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 192:307-19. 2011
    ..The localization of the ARSs close to the septate junctions enables efficient sealing of membrane gaps formed during nerve cord growth...
  41. pmc Prominent actin fiber arrays in Drosophila tendon cells represent architectural elements different from stress fibers
    Juliana Alves-Silva
    Faculty of Life Sciences, Wellcome Trust Centre of Cell Matrix Research, Manchester M13 9PT, United Kingdom
    Mol Biol Cell 19:4287-97. 2008
    ..Features reported here and elsewhere for tendon cells are reminiscent of the structural and molecular features of support cells in the inner ear of vertebrates, and they might have potential translational value...
  42. pmc Analysis of protein dynamics within the septate junction reveals a highly stable core protein complex that does not include the basolateral polarity protein Discs large
    Kenzi Oshima
    Department of Molecular Genetics and Cell Biology, University of Chicago, 920 E 58th Street, CLSC 925B, Chicago, IL 60637, USA
    J Cell Sci 124:2861-71. 2011
    ..Most SJ-associated proteins, including Coracle, Neurexin IV and Nervana 2, displayed similar, extremely immobile kinetics...
  43. pmc Polyploidization of glia in neural development links tissue growth to blood-brain barrier integrity
    Yingdee Unhavaithaya
    Whitehead Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Genes Dev 26:31-6. 2012
    ..Polyploidization likely is a conserved strategy to coordinate tissue growth during organogenesis, with potential vertebrate examples...
  44. pmc Subcellular trafficking of FGF controls tracheal invasion of Drosophila flight muscle
    Soren J Peterson
    Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5307, USA
    Cell 160:313-23. 2015
    ..We propose that tracheal invasion is controlled by an AP-1-dependent switch in FGF trafficking. Thus, subcellular targeting of a chemoattractant can direct outgrowth to specific domains, including inside the cell. ..
  45. pmc RhoGAP68F controls transport of adhesion proteins in Rab4 endosomes to modulate epithelial morphogenesis of Drosophila leg discs
    Beatriz Hernández de Madrid
    Department of Developmental, Molecular and Chemical Biology, Program in Cell, Molecular and Developmental Biology, Program in Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA
    Dev Biol 399:283-95. 2015
    ....
  46. pmc Pasiflora proteins are novel core components of the septate junction
    Myrto Deligiannaki
    Gene Center, Department of Biochemistry, Center of Protein Science CIPSM, Ludwigs Maximilians University, Feodor Lynen Str 25, Munich 81377, Germany
    Development 142:3046-57. 2015
    ..Taken together, our results show that Pasiflora1 and Pasiflora2 are novel integral components of the SJ and implicate a new family of tetraspan proteins in the function of these ancient and crucial cell junctions. ..
  47. pmc Type I bHLH Proteins Daughterless and Tcf4 Restrict Neurite Branching and Synapse Formation by Repressing Neurexin in Postmitotic Neurons
    Mitchell D'Rozario
    Department of Biology, Drexel University, Philadelphia, PA 19104, USA
    Cell Rep 15:386-97. 2016
    ..Our data indicate that Daughterless performs this function in part by restricting the expression of the cell adhesion molecule Neurexin. This suggests a role for these proteins outside of their established roles in neurogenesis.
  48. doi Developmental changes in beta-subunit composition of Na,K-ATPase in the Drosophila eye
    Otto Baumann
    Institute of Biochemistry and Biology, Department of Animal Physiology, University of Potsdam, Karl Liebknecht Strasse 24 25, 14476, Potsdam, Germany
    Cell Tissue Res 340:215-28. 2010
    ..The non-visual cells within the compound eye express almost exclusively Nrv2, which segregates together with the alpha-subunit to septate junctions throughout development...
  49. doi Blood-brain barrier defects associated with Rbp9 mutation
    Jihyun Kim
    Department of Molecular Biology, College of Life Sciences, Sejong University, Seoul, 143 747, Korea
    Mol Cells 29:93-8. 2010
    ..Putative Rbp9-binding sites were found in introns of genes that function in cell adhesion. Therefore, Rbp9 may regulate the splicing of cell adhesion molecules, critical for the formation of the BBB...
  50. doi Neurexin regulates visual function via mediating retinoid transport to promote rhodopsin maturation
    Yao Tian
    Institute of Life Sciences, The Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China
    Neuron 77:311-22. 2013
    Neurexins are cell adhesion molecules involved in synapse formation and synaptic regulation. Mutations in the neurexin genes are linked to a number of neurodevelopmental disorders such as autism...
  51. doi The actin-binding protein Canoe/AF-6 forms a complex with Robo and is required for Slit-Robo signaling during axon pathfinding at the CNS midline
    Jana Slováková
    Instituto de Neurociencias, CSIC UMH, 03550 Sant Joan d Alacant, Spain
    J Neurosci 32:10035-44. 2012
    ..genetic interactions between cno, slit, robo, and genes encoding other components of the Robo pathway, such as Neurexin-IV, Syndecan, and Rac GTPases, further confirm that Cno functionally interacts with the Slit-Robo pathway...
  52. doi Wunen, a Drosophila lipid phosphate phosphatase, is required for septate junction-mediated barrier function
    Kristina E Ile
    Max Planck Institute for Developmental Biology, Spemannstr 35, 72076 Tubingen, Germany
    Development 139:2535-46. 2012
    ..Furthermore, by comparing the rescue ability of different LPP homologs we show that wun function in the trachea is distinct from its role in germ cell migration...
  53. pmc Analysis of adhesion molecules and basement membrane contributions to synaptic adhesion at the Drosophila embryonic NMJ
    Andre Koper
    Faculty of Life Sciences, Wellcome Trust Centre for Cell Matrix Research, Manchester, United Kingdom
    PLoS ONE 7:e36339. 2012
    ..Therefore, future developmental studies of these synaptic junctions in Drosophila need to consider the important contribution made by BM-dependent mechanisms, in addition to CAM-dependent adhesion...
  54. pmc Drosophila hedgehog signaling and engrailed-runt mutual repression direct midline glia to alternative ensheathing and non-ensheathing fates
    JOSEPH D WATSON
    Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Development 138:1285-95. 2011
    ....
  55. ncbi Mutations in spalt cause a severe but reversible neurodegenerative phenotype in the embryonic central nervous system of Drosophila melanogaster
    Rafael Cantera
    Zoology Department, Stockholm University, S 106 91 Stockholm, Sweden
    Development 129:5577-86. 2002
    ..Effects on the expression of these genes are persistent but many morphological aspects of the phenotype are transient, leading to the concept of sequential redundancy for stable organisation of the central nervous system...
  56. pmc Towards a membrane proteome in Drosophila: a method for the isolation of plasma membrane
    Mansi R Khanna
    Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA
    BMC Genomics 11:302. 2010
    ..To facilitate genetic investigation of activities contributing to the content of the PM sub-proteome, we sought to adapt 2PAP to this invertebrate model to provide a robust PM isolation technique for Drosophila...
  57. ncbi Epithelial differentiation in Drosophila
    U Tepass
    Department of Zoology, University of Toronto, Ontario, Canada
    Bioessays 19:673-82. 1997
    ..The combination of embryological and genetic/molecular tools in Drosophila will help us to elucidate the complex events that determine epithelial cell structure and how they relate to morphogenesis and other developmental processes...
  58. ncbi The blood-brain barrier--lessons from moody flies
    Richard Daneman
    Department of Neurobiology, Stanford University School of Medicine, CA 94305, USA
    Cell 123:9-12. 2005
    ..Meanwhile, moody also has been identified in a screen for fly mutants with altered sensitivity to cocaine, remarkably implicating the BBB in the physiological response to narcotics...
  59. ncbi A transient luminal chitinous matrix is required to model epithelial tube diameter in the Drosophila trachea
    Anna Tonning
    Department of Medical Biochemistry, Gothenburg University, Sweden
    Dev Cell 9:423-30. 2005
    ..We propose that the transient luminal protein/polysaccharide matrix is sensed by the epithelial cells and coordinates cytoskeletal organization to ensure uniform lumen diameter...
  60. ncbi Close similarity between Drosophila neurexin IV and mammalian Caspr protein suggests a conserved mechanism for cellular interactions
    E Peles
    Cell 88:745-6. 1997
  61. ncbi Notch signaling controls cell fate specification along the dorsoventral axis of the Drosophila gut
    Bernhard Fuss
    Universitat Bonn, Institut fur Zoophysiologie, Abteilung Entwicklungsbiologie, Poppelsdorfer Schloss, D 53115 Bonn, Germany
    Curr Biol 12:171-9. 2002
    ..However, the genetic programs that control gut patterning along its dorsoventral (DV) axis have remained largely elusive...
  62. ncbi Rho1 interacts with p120ctn and alpha-catenin, and regulates cadherin-based adherens junction components in Drosophila
    Craig R Magie
    Division of Basic Sciences and Program in Developmental Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Development 129:3771-82. 2002
    ..Our observations suggest that alpha-catenin and p120(ctn) are key players in a mechanism of recruiting Rho1 to its sites of action...
  63. ncbi Glial cell development in the Drosophila embryo
    B W Jones
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, and Department of Pharmacology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Bioessays 23:877-87. 2001
    ..Other roles of glia are being explored, including their requirement for axon guidance, neuronal survival, and signaling...
  64. pmc A genetic analysis of the rose-gespleten region (68C8-69B5) of Drosophila melanogaster
    A M Hoogwerf
    Biochemistry Department, Oxford University, England
    Genetics 118:665-70. 1988
    ..None was rescued by the active Lsp-2 gene transformed on to chromosome II and we conclude that, as yet, we have no lethal mutations of Lsp-2...
  65. ncbi Grainy head controls apical membrane growth and tube elongation in response to Branchless/FGF signalling
    Johanna Hemphälä
    Department of Developmental Biology, Wenner Gren Institute, Stockholm University, S 10691 Stockholm, Sweden
    Development 130:249-58. 2003
    ....
  66. ncbi Role of the Crumbs complex in the regulation of junction formation in Drosophila and mammalian epithelial cells
    Emmanuelle Médina
    NMDA IBDM, UMR 6156, Campus de Luminy, Universite de la Mediterranee, Case 907, 13288 Marseille Cedex 09, France
    Biol Cell 94:305-13. 2002
    ..Finding an answer to these questions will help to find new therapies for Retinitis pigmentosa and other retina degeneration in which CRB1, the human homologue of crb, has been involved...
  67. pmc The AF-6 homolog canoe acts as a Rap1 effector during dorsal closure of the Drosophila embryo
    Benjamin Boettner
    Laboratory of Developmental Neurogenetics, Rockefeller University, New York, New York 10021, USA
    Genetics 165:159-69. 2003
    ..We further show that Rap1 acts upstream of Cno, but that Rap1, unlike Cno, is not involved in the stimulation of JNK pathway activity, indicating that Cno has both a Rap1-dependent and a Rap1-independent function in the DC process...
  68. ncbi Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization
    Guy Tanentzapf
    Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    Nat Cell Biol 5:46-52. 2003
    ....
  69. pmc Varicose: a MAGUK required for the maturation and function of Drosophila septate junctions
    Katherine E Moyer
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    BMC Dev Biol 8:99. 2008
    ..We characterize here a Drosophila MAGUK member, Varicose (Vari), the homologue of vertebrate scaffolding protein PALS2...
  70. ncbi The IgLON protein Lachesin is required for the blood-brain barrier in Drosophila
    Maura Strigini
    IMBB FORTH, Vassilika Vouton, Iraklio, Crete GR 71110, Greece
    Mol Cell Neurosci 32:91-101. 2006
    ..In Drosophila, SJ are found in epithelia and in the glia that form the blood-brain barrier (BBB). Drosophila NeurexinIV and Gliotactin, two components of SJ, play an important role in nerve ensheathment and insulation...
  71. ncbi Requirements for adherens junction components in the interaction between epithelial tissues during dorsal closure in Drosophila
    Nicole Gorfinkiel
    Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, UK
    J Cell Sci 120:3289-98. 2007
    ..Our results show that regulated cell adhesion is a crucial element of the interactions that shape epithelial sheets in morphogenetic processes...
  72. ncbi Drosophila arc encodes a novel adherens junction-associated PDZ domain protein required for wing and eye development
    X Liu
    Department of Molecular, Cell, and Developmental Biology, University of California at Los Angeles, Los Angeles, California, 90095 1606, USA
    Dev Biol 221:419-34. 2000
    ..Misexpression of arc in the eye imaginal discs results in rough and larger eyes with fused ommatidia. We propose that arc affects eye development by modulating adherens junctions of the developing ommatidium...
  73. pmc Axo-glial septate junctions. The maestro of nodal formation and myelination?
    B D Trapp
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Cell Biol 150:F97-F100. 2000
  74. ncbi JNK, cytoskeletal regulator and stress response kinase? A Drosophila perspective
    D C Goberdhan
    Research School of Biosciences, University of Kent at Canterbury, UK
    Bioessays 20:1009-19. 1998
    ..Here, we review this work and discuss how future experiments in Drosophila should reveal the cell type-specific mechanisms by which JNKs perform their diverse functions...
  75. ncbi [Dorsal closure in Drosophila. A genetic model for wound healing?]
    F Agnes
    Centre de Biologie du Developpement, UMR 5547, Toulouse, France
    C R Acad Sci III 322:5-13. 1999
    ..The molecular and cellular events that underlie these two analogous migratory processes are detailed, discussed and compared. We suggest that DC is a good genetic model for wound healing studying...
  76. ncbi A glial-neuronal signaling pathway revealed by mutations in a neurexin-related protein
    L L Yuan
    Neuroscience Training Program and Laboratory of Genetics, 445 Henry Mall, University of Wisconsin Madison, Madison, WI 53706 USA
    Science 283:1343-5. 1999
    ..Here the axotactin (axo) gene of Drosophila was shown to encode a member of the neurexin protein superfamily secreted by glia and subsequently localized to axonal tracts...
  77. pmc Discontinuous actin hexagon, a protein essential for cortical furrow formation in Drosophila, is membrane associated and hyperphosphorylated
    C X Zhang
    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Biol Cell 11:1011-22. 2000
    ..Both DAH localization and phosphorylation are disrupted in another maternal-effect mutant, nuclear-fallout. It is possible that nuclear-fallout collaborates with dah and directs DAH protein localization to the cortical furrows...
  78. ncbi JNK signaling and morphogenesis in Drosophila
    S Noselli
    Centre de Biologie du Developpement, UMR 5547 CNRS, Toulouse, France
    Trends Genet 14:33-8. 1998
  79. ncbi Cell polarity: squaring the circle
    D Bilder
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Avenue, Massachusetts, Boston 02115, USA
    Curr Biol 11:R132-5. 2001
    ..The results illustrate the reiterated use of groups of proteins to dictate cell polarity in epithelial and non-epithelial cells...
  80. doi Yurt, Coracle, Neurexin IV and the Na(+),K(+)-ATPase form a novel group of epithelial polarity proteins
    Patrick Laprise
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    Nature 459:1141-5. 2009
    ..Here we report that the Drosophila FERM proteins Yurt (Yrt) and Coracle (Cora) and the membrane proteins Neurexin IV (Nrx-IV) and Na(+),K(+)-ATPase are a new group of functionally cooperating epithelial polarity proteins...
  81. pmc Receptor tyrosine phosphatases control tracheal tube geometries through negative regulation of Egfr signaling
    Mili Jeon
    Broad Center, Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Development 136:3121-9. 2009
    ..PTPRJ corresponds to the murine Scc1 (suppressor of colon cancer) gene...
  82. pmc Requirement for chitin biosynthesis in epithelial tube morphogenesis
    W Patrick Devine
    Howard Hughes Medical Institute and Department of Biochemistry, Stanford University, Stanford, CA 94305 5307, USA
    Proc Natl Acad Sci U S A 102:17014-9. 2005
    ..These findings show that chitin regulates epithelial tube morphogenesis, in addition to its classical role protecting mature epithelia...
  83. pmc Epithelial polarity proteins regulate Drosophila tracheal tube size in parallel to the luminal matrix pathway
    Patrick Laprise
    Laval University Cancer Research Center, CRCHUQ Hôtel Dieu de Québec, 9 McMahon, Quebec, QC G1R 2J6, Canada
    Curr Biol 20:55-61. 2010
    ..Together, these data indicate that Yrt, Cora, Crb, and Scrib operate independently of the Verm pathway. Our data support a model in which Cora and Yrt act through Crb to regulate epithelial tube size...
  84. pmc A mosaic genetic screen for novel mutations affecting Drosophila neuroblast divisions
    Cathy Slack
    Temasek Lifesciences Laboratory, The National University of Singapore, 117604, Singapore
    BMC Genet 7:33. 2006
    ....
  85. pmc Perlecan and Dystroglycan act at the basal side of the Drosophila follicular epithelium to maintain epithelial organization
    Martina Schneider
    Department for Experimental Medical Science, Section for Developmental Biology, Lund University, Lund, Sweden
    Development 133:3805-15. 2006
    ..1) by recruiting/anchoring the cytoplasmic protein Dystrophin; and (2) by excluding the transmembrane protein Neurexin. We suggest that the interaction of Pcan and Dg at the basal side of the epithelium promotes basal membrane ..
  86. ncbi Control of endoreduplication domains in the Drosophila gut by the knirps and knirps-related genes
    B Fuss
    Institut fur Zoologie, Universitat Bonn, Abteilung Entwicklungsbiologie, Romerstrasse 164, D 53117 Bonn, Germany
    Mech Dev 100:15-23. 2001
    ..Our results provide a novel link between morphogen-dependent positional information and the spatio-temporal regulation of cell cycle activity in the gut...
  87. doi Drosophila Neurexin IV stabilizes neuron-glia interactions at the CNS midline by binding to Wrapper
    Tobias Stork
    Institut fur Neurobiologie, Universitat Munster, Badestrasse 9, D 48149 Munster, Germany
    Development 136:1251-61. 2009
    ..Here, we show that this wrapping of axons depends on the interaction of the neuronal transmembrane protein Neurexin IV with the glial Ig-domain protein Wrapper...

Research Grants3

  1. NEUREXIN IV, GROWTH CONTROL, AND CANCER
    Manzoor Bhat; Fiscal Year: 2002
    ..These junctions are composed of proteins that play both structural and/or signaling roles. Characterization of Neurexin IV (NRX IV), a septate junction associated protein in Drosophila, has established its role in blood-nerve barrier ..
  2. MOLECULAR MECHANISMS OF SCHWANN CELL MYELINATION
    Bruce Trapp; Fiscal Year: 2008
    ....
  3. Cellular Mechanisms for Oligodendrocyte Myelination
    Bruce D Trapp; Fiscal Year: 2010
    ..Collectively, these studies should identify therapeutic targets that enhance remyelination and reduce the progression of neurological disability in MS patients. ..