Genomes and Genes
Gene Symbol: Nrx-IV
Description: Neurexin IV
Alias: CG682, CG6827, CT21123, Dmel\CG6827, Dnrx, NRX, NRX IV, Nrx, Nrx IV, NrxIV, Nx IV, l(3)68Ff, l(3)rsg23, nrx, nrx IV, nrx-IV, nrxIV, rsg23, CG6827 gene product from transcript CG6827-RB, CG6827-PA, CG6827-PB, Neurexin-4, Neurexin-IV, Nrx-IV-PA, Nrx-IV-PB, neurexin, neurexin 4, neurexin IV, neurexinIV, rose-gespleten region interval 23
Species: fruit fly
- A homologue of the vertebrate SET domain and zinc finger protein Blimp-1 regulates terminal differentiation of the tracheal system in the Drosophila embryoTeclise Ng
Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore, 138673, Singapore
Dev Genes Evol 216:243-52. 2006..Further, using genetic analysis, we demonstrate that its wild-type activity is critically required for the maturation of the tracheal system into properly differentiated tubes...
- Axonal ensheathment and septate junction formation in the peripheral nervous system of DrosophilaSwati Banerjee
Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7545, USA
J Neurosci 26:3319-29. 2006..SJs are formed between the inner and outer glial membranes. We also show that Neurexin IV, Contactin, and Neuroglian are coexpressed in the peripheral glial membranes and that these proteins exist as a ..
- Neuroglian, Gliotactin, and the Na+/K+ ATPase are essential for septate junction function in DrosophilaJennifer L Genova
Department of Biology, Developmental, Cell, and Molecular Biology Group, Duke University, Durham, NC 27708, USA
J Cell Biol 161:979-89. 2003..In addition to the previously known components Coracle (COR) and Neurexin (NRX), we show that four other proteins, Gliotactin, Neuroglian (NRG), and both the alpha and beta subunits of ..
- The Na+/K+ ATPase is required for septate junction function and epithelial tube-size control in the Drosophila tracheal systemSarah M Paul
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA
Development 130:4963-74. 2003....
- The claudin-like megatrachea is essential in septate junctions for the epithelial barrier function in DrosophilaMatthias Behr
Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Am Fassberg, 37077 Gottingen, Germany
Dev Cell 5:611-20. 2003..addition, we present evidence that Mega is essential for localization of the septate junction protein complex Coracle/Neurexin. The results indicate that claudin-like proteins are functionally conserved between vertebrates and Drosophila.
- Molecular organization of axo-glial junctionsManzoor A Bhat
Department of Cell and Molecular Physiology, Neuroscience Center and Curriculum in Neurobiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Curr Opin Neurobiol 13:552-9. 2003..In addition, new roles for axo-glial paranodal septate junctions have emerged, which suggest that the paranodal region may act as an ionic barrier and a molecular fence in myelinated axons...
- Lachesin is a component of a septate junction-based mechanism that controls tube size and epithelial integrity in the Drosophila tracheal systemMarta Llimargas
Institut de Biologia Molecular de Barcelona, CSIC, 08034 Barcelona, Spain
Development 131:181-90. 2004..In addition, mutations in genes encoding other components of the SJs produce a similar tracheal phenotype. These results point out a new role of the SJs in morphogenesis regulating cell adhesion and cell size...
- Sinuous is a Drosophila claudin required for septate junction organization and epithelial tube size controlVictoria M Wu
Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Hogan Hall, Rm 2 100, Northwestern University, 2205 Tech Drive, Evanston, IL 60208 3500, USA
J Cell Biol 164:313-23. 2004..using a sinuous null mutation suggests that sinuous functions in the same pathway as the septate junction genes neurexin and scribble, but that nervana 2, convoluted, varicose, and cystic have functions not shared by sinuous...
- A junctional problem of apical proportions: epithelial tube-size control by septate junctions in the Drosophila tracheal systemVictoria M Wu
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Hogan Hall Rm 2 100, 2205 Tech Dr, Evanston, Illinois 60208, USA
Curr Opin Cell Biol 16:493-9. 2004..Possible tube-size functions of septate junctions include patterning of the apical extracellular matrix and regulation of conserved cell polarity genes such as Scribble and Discs Large...
- Drosophila contactin, a homolog of vertebrate contactin, is required for septate junction organization and paracellular barrier functionCatherine Faivre-Sarrailh
Neurobiologie des Interactions Cellulaires et Neurophysiopathologie, UMR 6184 CNRS, Institut Jean Roche, Boulevard Pierre Dramard, 13916 Marseille Cedex 20, France
Development 131:4931-42. 2004..Mutational analyses have shown that vertebrate NCP1 and its Drosophila homolog, Neurexin IV (NRX IV) are required for the formation of SJs...
- Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor ScribbleJennifer Zeitler
Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA
J Cell Biol 167:1137-46. 2004..We suggest a model in which Scrib, via the activity of the LRR, governs proliferation primarily by regulating apicobasal polarity...
- GPCR signaling is required for blood-brain barrier formation in drosophilaTina Schwabe
Laboratory of Developmental Neurogenetics, Rockefeller University, New York, NY 10021, USA
Cell 123:133-44. 2005..Our study demonstrates the importance of morphogenetic regulation in blood-brain barrier development and places GPCR signaling at its core...
- Septate-junction-dependent luminal deposition of chitin deacetylases restricts tube elongation in the Drosophila tracheaShenqiu Wang
Department of Developmental Biology, Wenner Gren Institute, Stockholm University, Arrhenius Labs E3, S 10691 Stockholm, Sweden
Curr Biol 16:180-5. 2006..We propose that the subsequent structural modification of chitin by chitin binding deacetylases selectively instructs the termination of tube elongation to the underlying epithelium...
- Claudins in occluding junctions of humans and fliesMikio Furuse
Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
Trends Cell Biol 16:181-8. 2006..Interestingly, claudin-like molecules have recently been identified in septate junctions of Drosophila. Here, we present an overview of recent progress in claudin studies conducted in mammals and flies...
- A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and functionS Baumgartner
Friedrich Miescher Institute, Basel, Switzerland
Cell 87:1059-68. 1996..We have characterized a novel member of the neurexin family, Neurexin IV (NRX), which is localized to septate junctions (SJs) of epithelial and glial cells...
- Gliotactin and Discs large form a protein complex at the tricellular junction of polarized epithelial cells in DrosophilaJoost Schulte
Department of Zoology, University of British Columbia, Vancouver, V6T 1Z3, Canada
J Cell Sci 119:4391-401. 2006..Finally this work supports a model where Gliotactin and Dlg are components of a larger protein complex that links the converging SJs with the TCJ to create the transepithelial barrier...
- Organization and function of the blood-brain barrier in DrosophilaTobias Stork
Institut fur Neurobiologie, Universitat Munster, D 48149 Münster Germany
J Neurosci 28:587-97. 2008....
- dGRASP-mediated noncanonical integrin secretion is required for Drosophila epithelial remodelingHans Schotman
The Cell Microscopy Centre, Department of Cell Biology, Institute of Biomembranes, University Medical Centre Utrecht, AZU Room G02 525, Heidelberglaan 100, 3584CX Utrecht, The Netherlands
Dev Cell 14:171-82. 2008..We speculate that this mechanism might be used during development as a means of targeting a specific subset of transmembrane proteins to the plasma membrane...
- Septate junctions are required for ommatidial integrity and blood-eye barrier function in DrosophilaSwati Banerjee
Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Dev Biol 317:585-99. 2008..We show that the localization of Neurexin IV (Nrx IV), a SJ-specific protein, coincides with the location of SJs in the cone and pigment cells...
- On the role of the MAGUK proteins encoded by Drosophila varicose during embryonic and postembryonic developmentANDRE BACHMANN
Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstr 1, 40225 Dusseldorf, Germany
BMC Dev Biol 8:55. 2008..They often appear in different variants suggesting that they also mediate dynamic changes in the composition of the complexes...
- The lateral mobility of cell adhesion molecules is highly restricted at septate junctions in DrosophilaMonique Laval
Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, UMR 6231 CNRS, Marseille, France
BMC Cell Biol 9:38. 2008A complex of three cell adhesion molecules (CAMs) Neurexin IV(Nrx IV), Contactin (Cont) and Neuroglian (Nrg) is implicated in the formation of septate junctions between epithelial cells in Drosophila...
- Neurexin IV and Wrapper interactions mediate Drosophila midline glial migration and axonal ensheathmentScott R Wheeler
Department of Biochemistry and Biophysics, The University of North Carolina, Chapel Hill, NC 27599, USA
Development 136:1147-57. 2009..By contrast, Neurexin IV is present on the membranes of neurons and commissural axons, and is highly concentrated at their interfaces ..
- CNTNAP2 and NRXN1 are mutated in autosomal-recessive Pitt-Hopkins-like mental retardation and determine the level of a common synaptic protein in DrosophilaChristiane Zweier
Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, 91054 Erlangen, Germany
Am J Hum Genet 85:655-66. 2009Heterozygous copy-number variants and SNPs of CNTNAP2 and NRXN1, two distantly related members of the neurexin superfamily, have been repeatedly associated with a wide spectrum of neuropsychiatric disorders, such as developmental language ..
- The Drosophila Claudin Kune-kune is required for septate junction organization and tracheal tube size controlKevin S Nelson
Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
Genetics 185:831-9. 2010..Double- and triple-mutant combinations of Sinuous and Megatrachea with Kune-kune resemble the Kune-kune single mutant, suggesting that Kune-kune has a more central role in septate junction formation than either Sinuous or Megatrachea...
- Drosophila neurexin IV interacts with Roundabout and is required for repulsive midline axon guidanceSwati Banerjee
Department of Cell and Molecular Physiology, University of North Carolina Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7545, USA
J Neurosci 30:5653-67. 2010..Here, we report that the Drosophila transmembrane septate junction-specific protein Neurexin IV (Nrx IV) functions in midline repulsive axon guidance...
- Neurexin in embryonic Drosophila neuromuscular junctionsKaiyun Chen
Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, United States of America
PLoS ONE 5:e11115. 2010b>Neurexin is a synaptic cell adhesion protein critical for synapse formation and function. Mutations in neurexin and neurexin-interacting proteins have been implicated in several neurological diseases...
- Canoe functions at the CNS midline glia in a complex with Shotgun and Wrapper-Nrx-IV during neuron-glia interactionsJana Slováková
Instituto de Neurociencias de Alicante, CSIC UMH, Sant Joan d Alacant, Alicante, Spain
Development 138:1563-71. 2011..unveil Cno function as a novel regulator of neuron-glia interactions, forming a complex with Shg, Wrapper and Neurexin IV, the homolog of vertebrate Caspr/paranodin...
- The regulation of glial-specific splicing of Neurexin IV requires HOW and Cdk12 activityFloriano Rodrigues
Institut fur Neurobiologie, Universitat Munster, Badestrasse 9, 48149 Munster, Germany
Development 139:1765-76. 2012..In the fly BBB, glial cells establish intensive septate junctions that require the cell-adhesion molecule Neurexin IV. Alternative splicing generates two different Neurexin IV isoforms: Neurexin IV(exon3), which is found in cells ..
- Localization of apical epithelial determinants by the basolateral PDZ protein ScribbleD Bilder
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 403:676-80. 2000..Our results show that the lateral domain of epithelia, particularly the septate junction, functions in restricting apical membrane identity and correctly placing adherens junctions...
- Composition and formation of intercellular junctions in epithelial cellsElisabeth Knust
Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstrasse 1, 40225 Dusseldorf, Germany
Science 298:1955-9. 2002..Comparisons between fly, worm, and vertebrate epithelia reveal marked similarities with respect to the molecules used, and pronounced differences in the organization of the junctions themselves...
- Gliotactin, a novel marker of tricellular junctions, is necessary for septate junction development in DrosophilaJoost Schulte
Dept of Zoology, University of British Columbia, Vancouver, Canada
J Cell Biol 161:991-1000. 2003..In Gli mutants, localization of SJ markers neurexin-IV, discs large, and coracle are disrupted...
- Drosophila coracle, a member of the protein 4.1 superfamily, has essential structural functions in the septate junctions and developmental functions in embryonic and adult epithelial cellsR S Lamb
Developmental, Cellular, and Molecular Biology Group, Duke University, Durham, North Carolina 27708 1000, USA
Mol Biol Cell 9:3505-19. 1998..1 superfamily members. These studies provide insights into a range of in vivo functions for coracle in developing embryos and adults...
- Neurexin IV, caspr and paranodin--novel members of the neurexin family: encounters of axons and gliaH J Bellen
Dept of Human and Molecular Genetics, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
Trends Neurosci 21:444-9. 1998..b>Neurexin IV, a molecular component of Drosophila septate junctions, has been shown to be essential for axonal insulation in ..
- Structure and evolution of neurexin genes: insight into the mechanism of alternative splicingKatsuhiko Tabuchi
Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
Genomics 79:849-59. 2002..We now show that Drosophila melanogaster and Caenorhabditis elegans express a single gene encoding only an alpha-neurexin, whereas humans and mice express three genes, each of which encodes alpha- and beta-neurexins transcribed from ..
- A conserved functional domain of Drosophila coracle is required for localization at the septate junction and has membrane-organizing activityR E Ward
Developmental, Cell, and Molecular Biology Group, Department of Zoology, Duke University, Durham, North Carolina 27708 1000, USA
J Cell Biol 140:1463-73. 1998..Furthermore, the localization of Coracle and the transmembrane protein Neurexin to the septate junction display an interdependent relationship, suggesting that Coracle and Neurexin interact ..
- The splicing factor crooked neck associates with the RNA-binding protein HOW to control glial cell maturation in DrosophilaGundula Edenfeld
Institut fur Neurobiologie, Universitat Munster, Badestrasse 9, D 48149 Munster, Germany
Neuron 52:969-80. 2006....
- Discs Lost, a novel multi-PDZ domain protein, establishes and maintains epithelial polarityM A Bhat
Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Cell 96:833-45. 1999..of development, DLT interacts with the apical determinant Crumbs (CRB) and the laterally localized protein Neurexin IV (NRX IV)...
- The CD59 family member Leaky/Coiled is required for the establishment of the blood-brain barrier in DrosophilaMubarak Hussain Syed
Institut fur Neurobiologie, Universitat Munster, D 48149 Munster, Germany
J Neurosci 31:7876-85. 2011..In coiled mutants, the normal distribution of septate junction markers such as NeurexinIV, Coracle, or Discs large is disturbed...
- Epithelial septate junction assembly relies on melanotransferrin iron binding and endocytosis in DrosophilaKatarína Tiklová
Department of Developmental Biology, Wenner Gren Institute, Stockholm University, S 10691 Stockholm, Sweden
Nat Cell Biol 12:1071-7. 2010..Mouse MTf complements the defects of Drosophila MTf mutants. Drosophila provides the first genetic model for the functional dissection of MTf in epithelial junction assembly and morphogenesis...
- The Drosophila blood brain barrier is maintained by GPCR-dependent dynamic actin structuresMeital Hatan
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
J Cell Biol 192:307-19. 2011..The localization of the ARSs close to the septate junctions enables efficient sealing of membrane gaps formed during nerve cord growth...
- Prominent actin fiber arrays in Drosophila tendon cells represent architectural elements different from stress fibersJuliana Alves-Silva
Faculty of Life Sciences, Wellcome Trust Centre of Cell Matrix Research, Manchester M13 9PT, United Kingdom
Mol Biol Cell 19:4287-97. 2008..Features reported here and elsewhere for tendon cells are reminiscent of the structural and molecular features of support cells in the inner ear of vertebrates, and they might have potential translational value...
- Analysis of protein dynamics within the septate junction reveals a highly stable core protein complex that does not include the basolateral polarity protein Discs largeKenzi Oshima
Department of Molecular Genetics and Cell Biology, University of Chicago, 920 E 58th Street, CLSC 925B, Chicago, IL 60637, USA
J Cell Sci 124:2861-71. 2011..Most SJ-associated proteins, including Coracle, Neurexin IV and Nervana 2, displayed similar, extremely immobile kinetics...
- Polyploidization of glia in neural development links tissue growth to blood-brain barrier integrityYingdee Unhavaithaya
Whitehead Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Genes Dev 26:31-6. 2012..Polyploidization likely is a conserved strategy to coordinate tissue growth during organogenesis, with potential vertebrate examples...
- Subcellular trafficking of FGF controls tracheal invasion of Drosophila flight muscleSoren J Peterson
Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5307, USA
Cell 160:313-23. 2015..We propose that tracheal invasion is controlled by an AP-1-dependent switch in FGF trafficking. Thus, subcellular targeting of a chemoattractant can direct outgrowth to specific domains, including inside the cell. ..
- RhoGAP68F controls transport of adhesion proteins in Rab4 endosomes to modulate epithelial morphogenesis of Drosophila leg discsBeatriz Hernández de Madrid
Department of Developmental, Molecular and Chemical Biology, Program in Cell, Molecular and Developmental Biology, Program in Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA
Dev Biol 399:283-95. 2015....
- Pasiflora proteins are novel core components of the septate junctionMyrto Deligiannaki
Gene Center, Department of Biochemistry, Center of Protein Science CIPSM, Ludwigs Maximilians University, Feodor Lynen Str 25, Munich 81377, Germany
Development 142:3046-57. 2015..Taken together, our results show that Pasiflora1 and Pasiflora2 are novel integral components of the SJ and implicate a new family of tetraspan proteins in the function of these ancient and crucial cell junctions. ..
- Type I bHLH Proteins Daughterless and Tcf4 Restrict Neurite Branching and Synapse Formation by Repressing Neurexin in Postmitotic NeuronsMitchell D'Rozario
Department of Biology, Drexel University, Philadelphia, PA 19104, USA
Cell Rep 15:386-97. 2016..Our data indicate that Daughterless performs this function in part by restricting the expression of the cell adhesion molecule Neurexin. This suggests a role for these proteins outside of their established roles in neurogenesis.
- Developmental changes in beta-subunit composition of Na,K-ATPase in the Drosophila eyeOtto Baumann
Institute of Biochemistry and Biology, Department of Animal Physiology, University of Potsdam, Karl Liebknecht Strasse 24 25, 14476, Potsdam, Germany
Cell Tissue Res 340:215-28. 2010..The non-visual cells within the compound eye express almost exclusively Nrv2, which segregates together with the alpha-subunit to septate junctions throughout development...
- Blood-brain barrier defects associated with Rbp9 mutationJihyun Kim
Department of Molecular Biology, College of Life Sciences, Sejong University, Seoul, 143 747, Korea
Mol Cells 29:93-8. 2010..Putative Rbp9-binding sites were found in introns of genes that function in cell adhesion. Therefore, Rbp9 may regulate the splicing of cell adhesion molecules, critical for the formation of the BBB...
- Neurexin regulates visual function via mediating retinoid transport to promote rhodopsin maturationYao Tian
Institute of Life Sciences, The Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China
Neuron 77:311-22. 2013Neurexins are cell adhesion molecules involved in synapse formation and synaptic regulation. Mutations in the neurexin genes are linked to a number of neurodevelopmental disorders such as autism...
- The actin-binding protein Canoe/AF-6 forms a complex with Robo and is required for Slit-Robo signaling during axon pathfinding at the CNS midlineJana Slováková
Instituto de Neurociencias, CSIC UMH, 03550 Sant Joan d Alacant, Spain
J Neurosci 32:10035-44. 2012..genetic interactions between cno, slit, robo, and genes encoding other components of the Robo pathway, such as Neurexin-IV, Syndecan, and Rac GTPases, further confirm that Cno functionally interacts with the Slit-Robo pathway...
- Wunen, a Drosophila lipid phosphate phosphatase, is required for septate junction-mediated barrier functionKristina E Ile
Max Planck Institute for Developmental Biology, Spemannstr 35, 72076 Tubingen, Germany
Development 139:2535-46. 2012..Furthermore, by comparing the rescue ability of different LPP homologs we show that wun function in the trachea is distinct from its role in germ cell migration...
- Analysis of adhesion molecules and basement membrane contributions to synaptic adhesion at the Drosophila embryonic NMJAndre Koper
Faculty of Life Sciences, Wellcome Trust Centre for Cell Matrix Research, Manchester, United Kingdom
PLoS ONE 7:e36339. 2012..Therefore, future developmental studies of these synaptic junctions in Drosophila need to consider the important contribution made by BM-dependent mechanisms, in addition to CAM-dependent adhesion...
- Drosophila hedgehog signaling and engrailed-runt mutual repression direct midline glia to alternative ensheathing and non-ensheathing fatesJOSEPH D WATSON
Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
Development 138:1285-95. 2011....
- Mutations in spalt cause a severe but reversible neurodegenerative phenotype in the embryonic central nervous system of Drosophila melanogasterRafael Cantera
Zoology Department, Stockholm University, S 106 91 Stockholm, Sweden
Development 129:5577-86. 2002..Effects on the expression of these genes are persistent but many morphological aspects of the phenotype are transient, leading to the concept of sequential redundancy for stable organisation of the central nervous system...
- Towards a membrane proteome in Drosophila: a method for the isolation of plasma membraneMansi R Khanna
Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA
BMC Genomics 11:302. 2010..To facilitate genetic investigation of activities contributing to the content of the PM sub-proteome, we sought to adapt 2PAP to this invertebrate model to provide a robust PM isolation technique for Drosophila...
- Epithelial differentiation in DrosophilaU Tepass
Department of Zoology, University of Toronto, Ontario, Canada
Bioessays 19:673-82. 1997..The combination of embryological and genetic/molecular tools in Drosophila will help us to elucidate the complex events that determine epithelial cell structure and how they relate to morphogenesis and other developmental processes...
- The blood-brain barrier--lessons from moody fliesRichard Daneman
Department of Neurobiology, Stanford University School of Medicine, CA 94305, USA
Cell 123:9-12. 2005..Meanwhile, moody also has been identified in a screen for fly mutants with altered sensitivity to cocaine, remarkably implicating the BBB in the physiological response to narcotics...
- A transient luminal chitinous matrix is required to model epithelial tube diameter in the Drosophila tracheaAnna Tonning
Department of Medical Biochemistry, Gothenburg University, Sweden
Dev Cell 9:423-30. 2005..We propose that the transient luminal protein/polysaccharide matrix is sensed by the epithelial cells and coordinates cytoskeletal organization to ensure uniform lumen diameter...
- Close similarity between Drosophila neurexin IV and mammalian Caspr protein suggests a conserved mechanism for cellular interactionsE Peles
Cell 88:745-6. 1997
- Notch signaling controls cell fate specification along the dorsoventral axis of the Drosophila gutBernhard Fuss
Universitat Bonn, Institut fur Zoophysiologie, Abteilung Entwicklungsbiologie, Poppelsdorfer Schloss, D 53115 Bonn, Germany
Curr Biol 12:171-9. 2002..However, the genetic programs that control gut patterning along its dorsoventral (DV) axis have remained largely elusive...
- Rho1 interacts with p120ctn and alpha-catenin, and regulates cadherin-based adherens junction components in DrosophilaCraig R Magie
Division of Basic Sciences and Program in Developmental Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Development 129:3771-82. 2002..Our observations suggest that alpha-catenin and p120(ctn) are key players in a mechanism of recruiting Rho1 to its sites of action...
- Glial cell development in the Drosophila embryoB W Jones
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, and Department of Pharmacology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Bioessays 23:877-87. 2001..Other roles of glia are being explored, including their requirement for axon guidance, neuronal survival, and signaling...
- A genetic analysis of the rose-gespleten region (68C8-69B5) of Drosophila melanogasterA M Hoogwerf
Biochemistry Department, Oxford University, England
Genetics 118:665-70. 1988..None was rescued by the active Lsp-2 gene transformed on to chromosome II and we conclude that, as yet, we have no lethal mutations of Lsp-2...
- Grainy head controls apical membrane growth and tube elongation in response to Branchless/FGF signallingJohanna Hemphälä
Department of Developmental Biology, Wenner Gren Institute, Stockholm University, S 10691 Stockholm, Sweden
Development 130:249-58. 2003....
- Role of the Crumbs complex in the regulation of junction formation in Drosophila and mammalian epithelial cellsEmmanuelle Médina
NMDA IBDM, UMR 6156, Campus de Luminy, Universite de la Mediterranee, Case 907, 13288 Marseille Cedex 09, France
Biol Cell 94:305-13. 2002..Finding an answer to these questions will help to find new therapies for Retinitis pigmentosa and other retina degeneration in which CRB1, the human homologue of crb, has been involved...
- The AF-6 homolog canoe acts as a Rap1 effector during dorsal closure of the Drosophila embryoBenjamin Boettner
Laboratory of Developmental Neurogenetics, Rockefeller University, New York, New York 10021, USA
Genetics 165:159-69. 2003..We further show that Rap1 acts upstream of Cno, but that Rap1, unlike Cno, is not involved in the stimulation of JNK pathway activity, indicating that Cno has both a Rap1-dependent and a Rap1-independent function in the DC process...
- Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarizationGuy Tanentzapf
Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
Nat Cell Biol 5:46-52. 2003....
- Varicose: a MAGUK required for the maturation and function of Drosophila septate junctionsKatherine E Moyer
Department of Biology, McMaster University, Hamilton, Ontario, Canada
BMC Dev Biol 8:99. 2008..We characterize here a Drosophila MAGUK member, Varicose (Vari), the homologue of vertebrate scaffolding protein PALS2...
- The IgLON protein Lachesin is required for the blood-brain barrier in DrosophilaMaura Strigini
IMBB FORTH, Vassilika Vouton, Iraklio, Crete GR 71110, Greece
Mol Cell Neurosci 32:91-101. 2006..In Drosophila, SJ are found in epithelia and in the glia that form the blood-brain barrier (BBB). Drosophila NeurexinIV and Gliotactin, two components of SJ, play an important role in nerve ensheathment and insulation...
- Requirements for adherens junction components in the interaction between epithelial tissues during dorsal closure in DrosophilaNicole Gorfinkiel
Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, UK
J Cell Sci 120:3289-98. 2007..Our results show that regulated cell adhesion is a crucial element of the interactions that shape epithelial sheets in morphogenetic processes...
- Drosophila arc encodes a novel adherens junction-associated PDZ domain protein required for wing and eye developmentX Liu
Department of Molecular, Cell, and Developmental Biology, University of California at Los Angeles, Los Angeles, California, 90095 1606, USA
Dev Biol 221:419-34. 2000..Misexpression of arc in the eye imaginal discs results in rough and larger eyes with fused ommatidia. We propose that arc affects eye development by modulating adherens junctions of the developing ommatidium...
- Axo-glial septate junctions. The maestro of nodal formation and myelination?B D Trapp
Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Cell Biol 150:F97-F100. 2000
- JNK, cytoskeletal regulator and stress response kinase? A Drosophila perspectiveD C Goberdhan
Research School of Biosciences, University of Kent at Canterbury, UK
Bioessays 20:1009-19. 1998..Here, we review this work and discuss how future experiments in Drosophila should reveal the cell type-specific mechanisms by which JNKs perform their diverse functions...
- [Dorsal closure in Drosophila. A genetic model for wound healing?]F Agnes
Centre de Biologie du Developpement, UMR 5547, Toulouse, France
C R Acad Sci III 322:5-13. 1999..The molecular and cellular events that underlie these two analogous migratory processes are detailed, discussed and compared. We suggest that DC is a good genetic model for wound healing studying...
- A glial-neuronal signaling pathway revealed by mutations in a neurexin-related proteinL L Yuan
Neuroscience Training Program and Laboratory of Genetics, 445 Henry Mall, University of Wisconsin Madison, Madison, WI 53706 USA
Science 283:1343-5. 1999..Here the axotactin (axo) gene of Drosophila was shown to encode a member of the neurexin protein superfamily secreted by glia and subsequently localized to axonal tracts...
- Discontinuous actin hexagon, a protein essential for cortical furrow formation in Drosophila, is membrane associated and hyperphosphorylatedC X Zhang
Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
Mol Biol Cell 11:1011-22. 2000..Both DAH localization and phosphorylation are disrupted in another maternal-effect mutant, nuclear-fallout. It is possible that nuclear-fallout collaborates with dah and directs DAH protein localization to the cortical furrows...
- JNK signaling and morphogenesis in DrosophilaS Noselli
Centre de Biologie du Developpement, UMR 5547 CNRS, Toulouse, France
Trends Genet 14:33-8. 1998
- Cell polarity: squaring the circleD Bilder
Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Avenue, Massachusetts, Boston 02115, USA
Curr Biol 11:R132-5. 2001..The results illustrate the reiterated use of groups of proteins to dictate cell polarity in epithelial and non-epithelial cells...
- Yurt, Coracle, Neurexin IV and the Na(+),K(+)-ATPase form a novel group of epithelial polarity proteinsPatrick Laprise
Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
Nature 459:1141-5. 2009..Here we report that the Drosophila FERM proteins Yurt (Yrt) and Coracle (Cora) and the membrane proteins Neurexin IV (Nrx-IV) and Na(+),K(+)-ATPase are a new group of functionally cooperating epithelial polarity proteins...
- Receptor tyrosine phosphatases control tracheal tube geometries through negative regulation of Egfr signalingMili Jeon
Broad Center, Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Development 136:3121-9. 2009..PTPRJ corresponds to the murine Scc1 (suppressor of colon cancer) gene...
- Requirement for chitin biosynthesis in epithelial tube morphogenesisW Patrick Devine
Howard Hughes Medical Institute and Department of Biochemistry, Stanford University, Stanford, CA 94305 5307, USA
Proc Natl Acad Sci U S A 102:17014-9. 2005..These findings show that chitin regulates epithelial tube morphogenesis, in addition to its classical role protecting mature epithelia...
- Epithelial polarity proteins regulate Drosophila tracheal tube size in parallel to the luminal matrix pathwayPatrick Laprise
Laval University Cancer Research Center, CRCHUQ Hôtel Dieu de Québec, 9 McMahon, Quebec, QC G1R 2J6, Canada
Curr Biol 20:55-61. 2010..Together, these data indicate that Yrt, Cora, Crb, and Scrib operate independently of the Verm pathway. Our data support a model in which Cora and Yrt act through Crb to regulate epithelial tube size...
- A mosaic genetic screen for novel mutations affecting Drosophila neuroblast divisionsCathy Slack
Temasek Lifesciences Laboratory, The National University of Singapore, 117604, Singapore
BMC Genet 7:33. 2006....
- Perlecan and Dystroglycan act at the basal side of the Drosophila follicular epithelium to maintain epithelial organizationMartina Schneider
Department for Experimental Medical Science, Section for Developmental Biology, Lund University, Lund, Sweden
Development 133:3805-15. 2006..1) by recruiting/anchoring the cytoplasmic protein Dystrophin; and (2) by excluding the transmembrane protein Neurexin. We suggest that the interaction of Pcan and Dg at the basal side of the epithelium promotes basal membrane ..
- Control of endoreduplication domains in the Drosophila gut by the knirps and knirps-related genesB Fuss
Institut fur Zoologie, Universitat Bonn, Abteilung Entwicklungsbiologie, Romerstrasse 164, D 53117 Bonn, Germany
Mech Dev 100:15-23. 2001..Our results provide a novel link between morphogen-dependent positional information and the spatio-temporal regulation of cell cycle activity in the gut...
- Drosophila Neurexin IV stabilizes neuron-glia interactions at the CNS midline by binding to WrapperTobias Stork
Institut fur Neurobiologie, Universitat Munster, Badestrasse 9, D 48149 Munster, Germany
Development 136:1251-61. 2009..Here, we show that this wrapping of axons depends on the interaction of the neuronal transmembrane protein Neurexin IV with the glial Ig-domain protein Wrapper...
- NEUREXIN IV, GROWTH CONTROL, AND CANCERManzoor Bhat; Fiscal Year: 2002..These junctions are composed of proteins that play both structural and/or signaling roles. Characterization of Neurexin IV (NRX IV), a septate junction associated protein in Drosophila, has established its role in blood-nerve barrier ..
- MOLECULAR MECHANISMS OF SCHWANN CELL MYELINATIONBruce Trapp; Fiscal Year: 2008....
- Cellular Mechanisms for Oligodendrocyte MyelinationBruce D Trapp; Fiscal Year: 2010..Collectively, these studies should identify therapeutic targets that enhance remyelination and reduce the progression of neurological disability in MS patients. ..